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60. Comparing Protein and Gene Expression Signature between Nasal Polyps and Nasal Fluids in Chronic Rhinosinusitis.

Author

Hou, Yilin, Chen, Changhui, Li, Zhengqi, Lu, Tong, Sun, Lin, Wei, Yi, Li, Jian, and Wen, Weiping

Subjects
NASAL polyps, NASAL tumors, GENE expression, PROTEIN expression, SINUSITIS, POLYVINYL alcohol, ENDOSCOPIC surgery
Abstract

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a serious inflammatory condition. Nasal fluids (NFs) present a noninvasive alternative to nasal biopsy for studying CRSwNP pathogenesis. We aimed to compare the protein and mRNA inflammation signature between nasal polyps (NPs) and NFs. Method: The performance of polyvinyl alcohol (PVA) sponges and NFs absorbable device (NFAD) for collecting NFs from 20 patients with CRSwNP was compared using the Luminex assay. The other group consisted of four healthy controls and an additional 21 CRSwNP patients (including eosinophilic CRSwNP [ECRSwNP] and non-eosinophilic CRSwNP [NECRSwNP]) for protein quantification by Olink platform and gene expression evaluation by RNA-sequencing. Spearman's analysis was performed to detect correlations between protein expression levels in NFs and clinical assessment variables. Results: NFAD-collected NFs contained at least a 2-fold higher concentration of cytokines than that obtained using PVA sponge, and these cytokines levels are significantly associated with NPs (ρ > 0.45, p < 0.05). Differentially expressed proteins between NFs and NPs were significantly correlated in the ECRSwNP subgroup compared with controls (ρ = 0.41, p < 0.01). Levels of Th2/IL-13, MCP4, and CCL4, characteristic of eosinophilic infiltration, were increased in ECRSwNP patients. A significant correlation between gene and protein expression was observed (ρ = 0.34, p < 0.01). PDL2 levels in NFs were positively correlated with ECRSwNP postoperative recurrence, the nasal VAS, and SNOT-22 scores (ρ > 0.68, p < 0.05 for all). Conclusion: Our study revealed similarities and discrepancies in inflammatory signatures between NPs and NFs in the same CRSwNP patient. [ABSTRACT FROM AUTHOR]

Published
2024
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61. Post‐earthquake functionality assessment of subway stations considering the interdependency among sub‐systems.

Author

Wen, Weiping, Hu, Jie, Zhai, Changhai, and Pei, Shunshun

Subjects
*SUBWAY stations, *NATURAL disaster warning systems, *FAULT trees (Reliability engineering), *BAYESIAN analysis, *EARTHQUAKE damage
Abstract

This study proposes a framework for the post‐earthquake functionality assessment of subway stations, in which the effects of seismic damage of components and interdependency among sub‐systems are considered by combining the fault tree analysis and Bayesian network method, and the post‐earthquake functionality is quantified by combining multi‐agent simulation and simulation optimization methods. The effectiveness of this method is verified based on a numerical study of a typical subway station. The proposed framework can assist stakeholders of subway stations to systematically assess the functional performance of the system under different earthquake levels and provide support for the design and post‐earthquake emergency management of subway stations. [ABSTRACT FROM AUTHOR]

Published
2024
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66. Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization

Author

Huang, Ziyu, primary, Li, Yue, additional, Park, Heekuk, additional, Ho, Martin, additional, Bhardwaj, Kanchan, additional, Sugimura, Naoki, additional, Lee, Hye Won, additional, Meng, Huicui, additional, Ebert, Matthias P., additional, Chao, Kang, additional, Burgermeister, Elke, additional, Bhatt, Aadra P., additional, Shetty, Sudarshan A., additional, Li, Kai, additional, Wen, Weiping, additional, and Zuo, Tao, additional

Published
2023
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74. Permissible Scale Factors for Various Intensity Measures in Aftershock Ground Motion Scaling.

Author

Zhou, Bochang, Hu, Jie, Yuan, Cheng, Wen, Weiping, and Kong, Qingzhao

Subjects
GROUND motion, EARTHQUAKE aftershocks, EARTHQUAKE intensity, EARTHQUAKE resistant design, EARTHQUAKES, DATABASES
Abstract

This manuscript investigates the bias introduced by scaling aftershock ground motions when evaluating the performance of structures subjected to earthquake sequences. The study focuses on different hysteretic behaviors exhibited by structures and selects eight intensity measures as scale indicators. A benchmark database comprising 274 recorded mainshock–aftershock ground motions is utilized for analysis. The findings reveal that scaling aftershock records using intensity measures such as SI (seismic intensity), PGV (peak ground velocity), IC (Arias intensity), and Sa (spectral acceleration) relative to mainshock records effectively controls the mean bias within 30% throughout the entire period range, given a maximum scale factor of 10.0. However, it is observed that the additional damage in systems exhibiting un-degrading hysteretic behavior is more significantly affected by aftershock ground motion scaling compared to systems with degrading hysteretic behavior. Furthermore, scaling aftershock ground motions upwards using relative Sa tends to overestimate the additional damage incurred by structures. These results emphasize the importance of considering the specific hysteretic behavior of structures when applying aftershock ground motion scaling, as well as selecting appropriate intensity measures for accurate evaluation of structural performance. [ABSTRACT FROM AUTHOR]

Published
2023
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81. The Trends of Psychological Status of People Entering from High-Risk Areas of COVID-19 Coronavirus During the Quarantine in Dedicated Hotels: A Longitudinal Survey Study from Guangzhou, China

Author

Deng, Yanhong, Shi, Lishuo, Li, Jianxia, Jiang, Zhipeng, Xie, Chaojun, Luo, Shuangling, Ling, Li, Lin, Hualiang, Chen, Zongqiu, Zhao, Yunlong, Kang, Liang, Yuan, Jun, and Wen, Weiping

Subjects
Risk Management and Healthcare Policy, dedicated hotels, psychological distress, Health Policy, quarantine, Public Health, Environmental and Occupational Health, COVID-19, Original Research
Abstract

Yanhong Deng,1,&ast; Lishuo Shi,2,&ast; Jianxia Li,1,&ast; Zhipeng Jiang,3,&ast; Chaojun Xie,4 Shuangling Luo,3 Li Ling,5 Hualiang Lin,6 Zongqiu Chen,4 Yunlong Zhao,7 Liang Kang,3 Jun Yuan,4 Weiping Wen8 1Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, 510655, People’s Republic of China; 2Clinical Research Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, 510655, People’s Republic of China; 3Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, 510655, People’s Republic of China; 4Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong Province, 510440, People’s Republic of China; 5Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 6Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 7Medical Department, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, 510655, People’s Republic of China; 8Department of Otolaryngology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, Guangzhou, 510655, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weiping WenDepartment of Otolaryngology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, No. 26 Yuan Cun Er Heng Road, Guangzhou, 510655, People’s Republic of ChinaTel +86-20-87333733Email wenwp@mail.sysu.edu.cnJun YuanGuangzhou Center for Disease Control and Prevention, No. 1, Qide Road of Baiyun District, Guangzhou, Guangdong Province, 510440, People’s Republic of ChinaTel +86-20-36052333-1816Email yuanjuncom@163.comBackground: The quarantine in dedicated hotels has become an inevitable safety measure due to the frequent cross-border travel since the outbreak of COVID-19. The aim of the present study was to explore the trends in the psychological status of individuals entering from high-risk areas of COVID-19 coronavirus while quarantining in dedicated hotels.Methods: A total of 591 individuals who isolated in dedicated hotels were recruited between March and June 2020. Participants self-reported mental symptoms [Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS)] every three days during the quarantine. A mixed-effects linear regression model was used to assess the trends.Results: Participants reporting anxiety and depression symptoms at least one time during quarantine accounted for 4.5% and 18.4%, respectively. Their psychological status was alleviated during some first 9 days, and then it slightly deteriorated, which was suggested by SAS and SDS scores that were negatively correlated with the days of quarantine (T) (adjusted coefficient [β] − 0.81, 95% CI − 1.00 to − 0.62; and β − 0.75, 95% CI − 0.97 to − 0.53, respectively), and were positively correlated with the square of T (β 0.04, 95% CI 0.02 to 0.06; and β 0.04, 95% CI 0.02 to 0.06, respectively). The unemployed and 18∼ 30-year-old participants were prone to greater levels of psychological distress. No significant difference in the trend of mental health was found among different subgroups.Conclusion: The mental health of the people entering Guangzhou from high-risk areas of COVID-19 coronavirus resulted positive during the early period of quarantine in dedicated hotels, after which it deteriorated. The psychological status of individuals should be closely monitored at the beginning and after more than 9 days of quarantine, especially for individuals who are unemployed and 18∼ 30-year-old ones.Keywords: quarantine, dedicated hotels, psychological distress, COVID-19

Published
2021

82. Packed, Printable, and Polymorphic Return-Oriented Programming

Author

Lu, Kangjie, Zou, Dabi, Wen, Weiping, Gao, Debin, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Sommer, Robin, editor, Balzarotti, Davide, editor, and Maier, Gregor, editor

Published
2011
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87. Cyber Security

Author

Lu, Wei, Zhang, Yuqing, Wen, Weiping, Yan, Hanbing, and Li, Chao

Subjects
artificial intelligence, authentication, computer hardware, computer networks, computer security, computer systems, cryptography, data communication systems, data mining, data security, databases, information retrieval, network protocols, network security, privacy, signal processing, telecommunication networks, telecommunication systems, bic Book Industry Communication::U Computing & information technology::UR Computer security, bic Book Industry Communication::U Computing & information technology::UT Computer networking & communications, bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general::GPJ Coding theory & cryptology, bic Book Industry Communication::U Computing & information technology::UT Computer networking & communications::UTN Network security, bic Book Industry Communication::U Computing & information technology::UY Computer science::UYQ Artificial intelligence, bic Book Industry Communication::U Computing & information technology::UM Computer programming / software development::UMZ Software Engineering
Abstract

This open access book constitutes the refereed proceedings of the 17th International Annual Conference on Cyber Security, CNCERT 2021, held in Beijing, China, in AJuly 2021. The 14 papers presented were carefully reviewed and selected from 51 submissions. The papers are organized according to the following topical sections: ​data security; privacy protection; anomaly detection; traffic analysis; social network security; vulnerability detection; text classification.

Published
2022
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89. Type 2 and Type 17 Invariant Natural Killer T Cells Contribute to Local Eosinophilic and Neutrophilic Inflammation and Their Function Is Regulated by Mucosal Microenvironment in Nasal Polyps

Author

Ye, Xiaoyan, primary, Bao, Qing, additional, Chen, Hexin, additional, Meng, Qingxiang, additional, Li, Qianying, additional, Sun, Lin, additional, Li, Jian, additional, Lei, Wenbin, additional, Wen, Weiping, additional, He, Wenjing, additional, Jiao, Linyi, additional, Fang, Bixing, additional, Gao, Yifang, additional, and Li, Chunwei, additional

Published
2022
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91. Targeting EZH2 depletes LMP1-induced activated regulatory T cells enhancing antitumor immunity in nasopharyngeal carcinoma

Author

Sun, Wei, Chen, Lin, Tang, Jun, Zhang, Chengcheng, Wen, Yihui, and Wen, Weiping

Subjects
Antigens -- Analysis, Disease susceptibility -- Development and progression, Carcinoma -- Development and progression, T cells -- Analysis, Cancer, Tumors, Epstein-Barr virus, Health
Abstract

Byline: Wei. Sun, Lin. Chen, Jun. Tang, Chengcheng. Zhang, Yihui. Wen, Weiping. Wen Objective: Regulatory T cells (Tregs) are critical factors that impair antitumor immunity. Epstein-Barr virus (EBV)-encoded latent membrane [...]

Published
2020

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