51. CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.
- Author
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Van Kaer L, Algood HMS, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, and Olivares-Villagómez D
- Subjects
- Animals, Citrobacter rodentium immunology, Cytochalasin D pharmacology, Enterocolitis, Necrotizing, Helicobacter pylori immunology, Histocompatibility Antigens Class I biosynthesis, Humans, Inhibitor of Differentiation Protein 2 genetics, Interleukin Receptor Common gamma Subunit biosynthesis, Interleukin-15 biosynthesis, Interleukin-2 biosynthesis, Interleukin-7 biosynthesis, Intestinal Mucosa immunology, Lymphocyte Activation immunology, Lymphocytes classification, Lymphocytes cytology, Mice, Mice, Inbred C57BL, Mice, Knockout, Phagocytosis drug effects, Phagocytosis immunology, Antigen Presentation immunology, CD8 Antigens biosynthesis, Immunity, Mucosal immunology, Intestinal Mucosa cytology, Lymphocytes immunology
- Abstract
Innate immune responses are critical for mucosal immunity. Here we describe an innate lymphocyte population, iCD8α cells, characterized by expression of CD8α homodimers. iCD8α cells exhibit innate functional characteristics such as the capacity to engulf and kill bacteria. Development of iCD8α cells depends on expression of interleukin-2 receptor γ chain (IL-2Rγc), IL-15, and the major histocompatibility complex (MHC) class Ib protein H2-T3, also known as the thymus leukemia antigen or TL. While lineage tracking experiments indicated that iCD8α cells have a lymphoid origin, their development was independent of the transcriptional suppressor Id2, suggesting that these cells do not belong to the family of innate lymphoid cells. Finally, we identified cells with a similar phenotype in humans, which were profoundly depleted in newborns with necrotizing enterocolitis. These findings suggest a critical role of iCD8α cells in immune responses associated with the intestinal epithelium., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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