51. POS0537 TRENDS AND PREDICTORS OF INPATIENT MORTALITY IN PATIENTS WITH CLOSTRIDIODES DIFFICILE INFECTION AMONG THOSE WITH AND WITHOUT RHEUMATOID ARTHRITIS: A NATIONWIDE ANALYSIS
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Muhammad Waqas Tahir, Raseen Tariq, Katherine D Wysham, J. Andrews, S. Alexander, Namrata Singh, Sahil Khanna, and H. Aly
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medicine.medical_specialty ,Inpatient mortality ,Rheumatology ,business.industry ,Internal medicine ,Rheumatoid arthritis ,Immunology ,medicine ,Immunology and Allergy ,In patient ,medicine.disease ,business ,General Biochemistry, Genetics and Molecular Biology - Abstract
Background:People with rheumatoid arthritis (RA) have a higher risk of serious infections. The most common nosocomial infection in the United States (US) is Clostridioides difficile infection (CDI) and yet, little is known regarding the impact of comorbid RA on outcomes in persons hospitalized with CDI.Objectives:To evaluate the trends over time and predictors of inpatient mortality in hospitalized patients with CDI comparing those with and without RA.Methods:We used the National Inpatient Sample (NIS) database, the largest available all-payer database of inpatient hospitalizations in the US. Patients aged ≥18 years admitted with CDI from 2006-2018 were included. Patients with RA were identified using the International Classification of Diseases (ICD) 9 and 10 codes. Categorical variables between CDI patients with and without RA were compared using Chi-squared test. Temporal trends of hospitalization charges, length of stay (LOS) and inpatient mortality were assessed using the Cochrane Armitage test. Predictors of inpatient mortality were assessed using multivariable logistic regression adjusting for: age ≥65, sex, race, presence of RA, and Elixhauser comorbidity index.Results:There were 4,396,945 hospitalizations with a discharge diagnosis of CDI in the study period, of which 111,336 (2.5%) had a coexisting diagnosis of RA. Over the study period, the proportion of CDI patients with a diagnosis of RA increased from 1.7% in 2006 to 3.3% in 2018 with a statistically significant trend of rise (p trendp The inflation-adjusted average charge for hospitalization for CDI without RA was significantly higher than for CDI with RA ($95,863 vs $73,025, pCDI patients without RA had a significantly higher mortality over the study period than those with RA (7.8% vs 6.1%, pThe multivariable analyses found age≥65 was associated with increased inpatient mortality (adjusted odds ratio [aOR], 1.77, 95% confidence interval [CI], 1.73-1.80), whereas a diagnosis of RA was associated with a decreased mortality (aOR 0.86, 95% CI, 0.81-0.91) (Table 1).Table 1.Predictors of inpatient mortalityaOR95% C.I. for aORP-valueLowerUpperAge ≥ 651.7651.7301.801Hospitalization years -Years 2006-2011Ref -Years 2011-20140.7070.6930.721 -Years 2015-20180.5820.5690.594Elixhauser Comorbidity Index1.0561.0551.056Rheumatoid Arthritis0.8590.8100.911Female0.8700.8550.885Race -WhiteRef -African American1.0711.0441.099 -Hispanic1.1441.1081.180 -Asian/Pacific Islander1.2671.2001.337 -Native American1.0220.9101.1470.716 -Other races1.2631.2011.329aOR = Adjusted Odds Ratio; C.I.= confidence intervalConclusion:In this nationwide study, among hospitalized patients with CDI, those with comorbid RA had significantly decreased odds of inpatient mortality than those without RA. Further studies are needed to understand this association.Figure 1.Disclosure of Interests:None declared
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- 2021