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357 results on '"Wangchuk, Phurpa"'

54. Examining Ozone Sensitivity in the Genus Musa (Bananas)

Author

Farha, Mst Nahid, primary, Daniells, Jeff, additional, Cernusak, Lucas A., additional, Ritmejerytė, Edita, additional, Wangchuk, Phurpa, additional, Sitch, Stephen, additional, Mercado, Lina M., additional, Hayes, Felicity, additional, Brown, Flossie, additional, and Cheesman, Alexander W., additional

Published
2022
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58. Vascular epiphytic medicinal plants as sources of therapeutic agents: Their ethnopharmacological uses, chemical composition, and biological activities

Author

Nugraha, Ari S, Triatmoko, Bawon, Wangchuk, Phurpa, Keller, Paul A, Nugraha, Ari S, Triatmoko, Bawon, Wangchuk, Phurpa, and Keller, Paul A

Abstract

This is an extensive review on epiphytic plants that have been used traditionally as medicines. It provides information on 185 epiphytes and their traditional medicinal uses, regions where Indigenous people use the plants, parts of the plants used as medicines and their preparation, and their reported phytochemical properties and pharmacological properties aligned with their traditional uses. These epiphytic medicinal plants are able to produce a range of secondary metabolites, including alkaloids, and a total of 842 phytochemicals have been identified to date. As many as 71 epiphytic medicinal plants were studied for their biological activities, showing promising pharmacological activities, including as anti-inflammatory, antimicrobial, and anticancer agents. There are several species that were not investigated for their activities and are worthy of exploration. These epipythes have the potential to furnish drug lead compounds, especially for treating cancers, and thus warrant indepth investigations.

Published
2020

62. Phytochemical Screening and the Antimicrobial and Antioxidant Activities of Medicinal Plants of Meru Betiri National Park – Indonesia

Author

Nugraha, Ari Satia, primary, Permatasari, Agka Enggar Niken, additional, Kadarwenny, Carina Puspita, additional, Pratoko, Dwi Koko, additional, Triatmoko, Bawon, additional, Rosyidi, Viddy Agustian, additional, Norcahyanti, Ika, additional, Dewi, Ika Puspita, additional, Dianasari, Dewi, additional, Sary, Indah Purnama, additional, and Wangchuk, Phurpa, additional

Published
2020
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65. Anti-infective and anti-cancer properties of the Annona species: Their ethnomedicinal uses, alkaloid diversity, and pharmacological activities

Author

Nugraha, Ari S, Damayanti, Yuvita, Wangchuk, Phurpa, Keller, Paul A, Nugraha, Ari S, Damayanti, Yuvita, Wangchuk, Phurpa, and Keller, Paul A

Abstract

Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates for their anti-infective and anti-cancer activities. An isoquinoline backbone is a major structural alkaloid moiety of the Annona genus, and more than 83 alkaloids have been isolated from this genus alone. Crude extracts of Annona genus are reported with moderate activities against Plasmodium falciparum showing larvicidal activities. However, no pure compounds from the Annona genus were tested against the parasite. The methanol extract of Annona muricata showed apparent antimicrobial activities. The isolated alkaloids from this genus including liriodenine, anonaine, asimilobine showed sensitivity against Staphylococcus epidermidis. Other alkaloids such as (+)-Xylopine and isocoreximine indicated significant anti-cancer activity against A549 and K-562 cell lines, respectively. This review revealed that the alkaloids from Annona genus are rich in structural diversity and pharmacological activities. Further exploration of this genus and their alkaloids has potential for developing novel anti-infective and anticancer drugs.

Published
2019

67. List of contributors

Author

Abdullahi, A., Abubakar, A.I., Akram, Kashif, Ali, Heyam Saad, Al-Rajab, Abdul Jabbar, Balahbib, Abdelaali, Benali, Taoufiq, Betkar, Parag, Bienia, Bernadetta, Bigoli, Sima, Boskabady, Mohammad Hossein, Bouyahya, Abdelhakim, Burgos-Araiza, A.K., Chaitanya, M.V.N.L., Chaki, Rituparna, Chakraborty, Saptaparna, Charfi, Saoulajan, Chen, Yeng, Choudhury, Arun Paul, Choudhury, Birupakshya Paul, Delis-Hechavarria, Emilio, Desam, Nagarjuna Reddy, Dhara, Amal Kumar, El Menyiy, Naoual, El Omari, Nasreddine, Escamilla-García, Axel, Felix-Cuencas, Leticia, Feregrino-Pérez, Ana A., Gangasani, Jagadeesh Kumar, García-Trejo, Juan Fernando, Ghasemi, Seyyedeh Zahra, Ghorani, Vahideh, Ghosh, Aparajita, Ghosh, Nilanjan, Guaouguaou, Fatima-Ezzahrae, Guevara-González, Ramón Gerardo, Hasnain, Md Saquib, Ismail, M.R., Jarro, Alexandra, Joshi, Vidhi, Kandar, Chandi Charan, Karupiah, Sundram, Khairulmazmi, A., Khazdair, Mohammad Reza, Kosgi, Raghavender, Krochmal-Marczak, Barbara, Kılıç, Ceyda Sibel, Leong, Yin-Hui, Li, Rachel W., Lin, G. David, Logeiswariy, Perumal, Malik, Jai, Mandal, Subhash C., Memarzia, Arghavan, Mendoza-Meneses, C.J., Momin, Misbah, Mudau, F.N., Mukne, Alka, Murthy, U.S.N., Naidu, V.G.M., Nayak, Amit Kumar, Otimenyin, Sunday, Pal, Mahadeb, Parola-Contreras, Ixchel, Pemmaraju, Deepak Bharadwaj, Rengan, Aravind Kumar, Roychoudhury, Shubhadeep, Saadat, Saeideh, Santhiya-Nair, Kasevem, Sasidharan, Sreenivasan, Sawicka, Barbara, Shafi, Afshan, Shakila, Ramachandran, Shanmugapriya, Sinha, Ananya, Skiba, Dominika, Smith, Paul N., Soto-Blanco, Benito, Soto-Zarazúa, Genaro Martin, Sreeramanan, Subramaniam, Thibane, V.S., Tijjani, A., Torres-Pacheco, Irineo, Usamo, Firehiwot Belayneh, Wangchuk, Phurpa, and Yeshi, Karma

Published
2022
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70. Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

Author

Wangchuk, Phurpa, primary, Shepherd, Catherine, additional, Constantinoiu, Constantin, additional, Ryan, Rachael Y. M., additional, Kouremenos, Konstantinos A., additional, Becker, Luke, additional, Jones, Linda, additional, Buitrago, Geraldine, additional, Giacomin, Paul, additional, Wilson, David, additional, Daly, Norelle, additional, McConville, Malcolm J., additional, Miles, John J., additional, and Loukas, Alex, additional

Published
2019
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74. A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain

Author

Phurpa, Wangchuk, Wangchuk, Phurpa, Paul A, Keller, Stephen G, Pyne, Wilford, Lie, Anthony C, Willis, Roonglawan, Rattanajak, and Sumalee, Kamchonwongpaisan

Subjects
Pharmacology, biology, Cell Survival, Plant Extracts, Alkaloid, Berberine Alkaloids, Plasmodium falciparum, Meconopsis simplicifolia, biology.organism_classification, Multiple drug resistance, Antimalarials, chemistry.chemical_compound, Alkaloids, Meconopsis, chemistry, Phytochemical, Papaveraceae, Chlorocebus aethiops, Drug Discovery, Animals, Protopine, Bioassay, Vero Cells
Abstract

Ethnopharmacological relevance The aerial components of Meconopsis simplicifolia (D. Don) Walpers are indicated in Bhutanese traditional medicine for treating malaria, coughs and colds, and the infections of the liver, lung and blood. This study is to validate the ethnopharmacological uses of this plant and also identify potent antimalarial drug leads through bioassays of its crude extracts and phytochemical constituents. Materials and methods Meconopsis simplicifolia (D. Don) Walpers was collected from Bhutan and its crude MeOH extract was subjected to acid-base fractionation. Through repeated extractions, separations and spectroscopic analysis, the alkaloids obtained were identified and tested for their antimalarial and cytotoxicity activities. Results Phytochemical studies resulted in the isolation of one new protoberberine type alkaloid which we named as simplicifolianine and five known alkaloids: protopine, norsanguinarine, dihydrosanguinarine, 6-methoxydihydrosanguinarine and oxysanguinarine. Among the five of the alkaloids tested, simplicifolianine showed the most potent antiplasmodial activities against the Plasmodium falciparum strains, TM4/8.2 (chloroquine–antifolate sensitive strain) and K1CB1 (multidrug resistant strain) with IC50 values of 0.78 μg/mL and 1.29 μg/mL, respectively. The compounds tested did not show any significant cytotoxicity activities against human oral carcinoma KB cells and normal Vero cells of African kidney epithelial cells. Conclusions This study validated the traditional uses of the plant for the treatment of malaria and identified a new alkaloid, simplicifolianine as a potential antimalarial drug lead.

Published
2013

77. Hookworm-derived small molecule extracts suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes

Author

Wangchuk, Phurpa, primary, Constantinoiu, Constantin, additional, Kouremenos, Konstantinos A., additional, Becker, Luke, additional, Jones, Linda, additional, Shepherd, Catherine, additional, Buitrago, Geraldine, additional, Giacomin, Paul, additional, Daly, Norelle, additional, McConville, Malcolm J., additional, Ryan, Rachael Y. M., additional, Miles, John J., additional, and Loukas, Alex, additional

Published
2018
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80. Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing

Author

Weeks, Janis C., primary, Roberts, William M., additional, Leasure, Caitlyn, additional, Suzuki, Brian M., additional, Robinson, Kristin J., additional, Currey, Heather, additional, Wangchuk, Phurpa, additional, Eichenberger, Ramon M., additional, Saxton, Aleen D., additional, Bird, Thomas D., additional, Kraemer, Brian C., additional, Loukas, Alex, additional, Hawdon, John M., additional, Caffrey, Conor R., additional, and Liachko, Nicole F., additional

Published
2018
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83. Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases

Author

Sundaraneedi, Madhu K., primary, Tedla, Bemnet A., additional, Eichenberger, Ramon M., additional, Becker, Luke, additional, Pickering, Darren, additional, Smout, Michael J., additional, Rajan, Siji, additional, Wangchuk, Phurpa, additional, Keene, F. Richard, additional, Loukas, Alex, additional, Collins, J. Grant, additional, and Pearson, Mark S., additional

Published
2017
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94. List of Contributors

Author

Banerjee, Sugato, Basak, Souvik, Biswas, Tuhin K., Chaudhari, Anand K., Chen, Jihang, Chouhan, Kavi B.S., Das, Somenath, Dubey, Nawal K., Dutta, Anirban, Dwivedy, Abhishek K., Elachouri, Mostafa, Geetanjali, Ghosh, Nilanjan, Ghosh, Rituparna C., Gomes, Ciro M., Gunasekaran, Mahalakshmi, Gupta, Gaurav, Joshi, Dharmik, Kawagishi, Hirokazu, Ko, Kam M., Kumar, Sudhir, Kundu, Anindita, Kundu, Sukalyan K., Lall, Namrita, Leong, Pou K., Li, Rachel W., Lin, G. David, Loukas, Alex, Majumdar, Anuradha S., Mandal, Abhishek, Mandal, Vivekananda, Mandal, Subhash C., Maurya, Rakesh, Mukherjee, Dhrubojyoti, Naman, C. Benjamin, Namdeo, Ajay G., Otimenyin, Sunday O., Palit, Partha, Roy, Somdatta, Roychoudhury, Shubhadeep, Saha, Supradip, Sankaramourthy, Divya, Singh, Ram, Somani, Sahil J., Subramanian, Kavimani, Tandey, Roshni, Twilley, Danielle, Wangchuk, Phurpa, and Wangkheirakpam, Sujata

Published
2018
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97. Phytochemical analysis, bioassays and the identification of drug lead compounds from seven Bhutanese medicinal plants

Author

Wangchuk, Phurpa and Wangchuk, Phurpa

Abstract

The Bhutanese traditional medicine (BTM) has been integrated with biomedicine since 1967 and serves as one of the important health care delivery systems in Bhutan. Therefore, the need to imrpove its quality through scientific studies have become paramount. In our efforts to address this important issue, we authenticated the botanical names of low altitude medicinal plants, determined the major classes of phytochemicals of 25 selected species, evaluated the bioactivities of the crude extracts of seven of them, and finally isolated the phytochemicals from six of these plants. We have established the antimalarial, anti-inflammatory, antimicrobial, and cytotoxicity activities of these phytochemicals and also identified five novel drug lead compounds. In our ethnobotanical study; we resolved the traditional and taxonomical discrepancies for Bhutanese medicinal plants, assessed the current BTM formulations, and carried out the field survey for the low altitude medicinal plants (LAMP), which is described in Chapter 2. Out of 113 LAMP, 92 species are used in the current multiingredient formulations produced by Manjong Sorig Pharmaceuticals (MSP) and 28 of them are currently imported from India. Out of these 28 species, 16 of them are found growing abundantly in Bhutan and most of them have not been studied for their phytochemicals and pharmacological properties. In this study, we have selected 25 of these plants and assessed them for their major classes of phytochemicals which we have described in Chapter 3. Of these, the crude extracts of seven selected plants (Corydalis crispa, C. dubia, Ajania nubegina, Meconopsis simplicifolia, Pleurospermum amabile, Aconitum laciniatum and Codonopsis bhutanica) were investigated for their biological activities and we found that five of them possessed significant antiplasmodial activities, one species showed moderate cytotoxicity, two species exhibited moderate anti-Trypanosoma brucei rhodesiense activity, six species exhibited signific

Published
2014

98. Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile

Author

Wangchuk, Phurpa, Pyne, Stephen G, Keller, Paul, Taweechotipatr, Malai, Kamchonwongpaisan, Sumalee, Wangchuk, Phurpa, Pyne, Stephen G, Keller, Paul, Taweechotipatr, Malai, and Kamchonwongpaisan, Sumalee

Abstract

With the objective of determining safety and verifying the traditional uses of the Bhutanese medicinal plant, Pleurospermum amabile Craib & W. W. Smith, we investigated its crude extracts and the isolated phytochemicals for their biological activities. Four phenylpropanoids [(E)-isomyristicin (1), (E)-isoapiol (2 ), methyl eugenol (3) and (E)-isoelemicin (4)] and six furanocoumarins [psoralen (5), bergapten (6), isoimperatorin (7), isopimpinellin (8 ), oxypeucedanin hydrate (9) and oxypeucedanin methanolate (10 )] were isolated from this plant. Among the test samples, compound 10 showed weak antibacterial activity against Bacillus subtilis and best antimalarial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). None of the test samples showed cytotoxicity. This study generated scientific data that support the traditional medical uses of the plant.

Published
2014

99. Antioxidant Activity and the Polyphenolic and Flavonoid Contents of Five High Altitude Medicinal Plants Used in Bhutanese Sowa rigpa Medicine.

Author

Yeshi, Karma, Yangdon, Pema, Kashyap, Shakuli, and Wangchuk, Phurpa

Subjects
CHINESE medicine, MEDICINAL plants, ANTIOXIDANTS & health, POLYPHENOLS, PHYSIOLOGICAL effects of flavonoids, FREE radical scavengers, SUPEROXIDE dismutase, PHYSIOLOGY
Abstract

In this work, total phenolic and flavonoid contents and antioxidant activities in methanol and aqueous extracts of five-high altitude medicinal plants namelyAconogonon tortuosum, Thlaspi arvense, Erysimum bhutanicum, Thalictrum chelidoniiandAletris pauciflorawere studied for the first time from Bhutan. Antioxidant activities were investigated using DPPH radical scavenging activity (DRSA), ferric reducing antioxidant power (FRAP), superoxide dismutase (SOD) and catalase (CAT) assays. Significant level of phenolics and flavonoids were found in all medicinal herbs. Among the five plants studied, aqueous extract ofThalictrum chelidoniiand methanol extract ofErysimum bhutanicumshowed best free radical scavenging activity. Both aqueous and methanol extracts ofAconogonon tortuosumshowed strong ferric reducing antioxidant power. The results indicate that all five medicinal herbs could be potential sources of natural antioxidant compounds and could help boost the immune system of patients. [ABSTRACT FROM AUTHOR]

Published
2017
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