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271 results on '"Wang Zhuoya"'

57. Establishment of induced pluripotent stem cell line (ZZUi033-A) of a male with a novel L1CAM missense mutation

Author

Li, Shaohua, primary, Wang, Yunchao, additional, Sun, Huifang, additional, Wang, Zhuoya, additional, Zhang, Qi, additional, Wang, Yanlin, additional, Yang, Jing, additional, Shi, Changhe, additional, Yuan, Yanpeng, additional, Wang, Hao, additional, Wang, Anran, additional, Hu, Zhengwei, additional, Li, Zhuo, additional, and Xu, Yuming, additional

Published
2022
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73. Outside‐In Nanostructure Fabricated on LiCoO2 Surface for High‐Voltage Lithium‐Ion Batteries.

Author

Mao, Shulan, Shen, Zeyu, Zhang, Weidong, Wu, Qian, Wang, Zhuoya, and Lu, Yingying

Subjects
LITHIUM-ion batteries, LITHIUM cobalt oxide, ENERGY density, LITHIUM cells, CONCENTRATION gradient, SUPERIONIC conductors, HIGH voltages, COBALT
Abstract

The energy density of batteries with lithium cobalt oxide (LCO) can be maximized by increasing the cut‐off voltage to approach the theoretical capacity limit. However, it is not realized in the practical applications due to the restricted cycle life caused by vulnerable cathode surface in deep delithiation state, where severe side reactions, oxygen/cobalt loss and structure degradation often happen. Here, an outside‐in oriented nanostructure on LiCoO2 crystals is fabricated. The outer electrochemically stable LiF and Li2CoTi3O8 particles perform as physical barrier to prevent damage of both cathodes and electrolytes, while the inner F doping promote Li ions diffusivity and stabilize the lattice oxygen. With the spinel‐like transition layer between them, a solid and complete lithium‐ion transport channel generation along the lithium concentration gradient. Under the protection from this structure, the LiCoO2 withstand the high voltage of 4.6 V and the LCO/graphite pouch full cell with high loading density exhibits 81.52% energy density retention after 135 cycles at 4.5 V. [ABSTRACT FROM AUTHOR]

Published
2022
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74. Construction of induced pluripotent stem cell line (ZZUi0017-A) from the fibroblast cells of a female patient with CACNA1A mutation by unintegrated reprogramming approach

Author

Yang, Jing, primary, Liu, Han, additional, Sun, Huifang, additional, Wang, Zhuoya, additional, Zhang, Rui, additional, Liu, Yutao, additional, Zhang, Qi, additional, Zhang, Shoutao, additional, Zhang, Jin, additional, Shi, Changhe, additional, Wang, Yanlin, additional, and Xu, Yuming, additional

Published
2020
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75. A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses

Author

Wang, Yuxin, primary, Song, Qiaoling, additional, Huang, Wei, additional, Lin, Yuxi, additional, Wang, Xin, additional, Wang, Chenyao, additional, Willard, Belinda, additional, Zhao, Chenyang, additional, Nan, Jing, additional, Holvey-Bates, Elise, additional, Wang, Zhuoya, additional, Taylor, Derek, additional, Yang, Jinbo, additional, and Stark, George R., additional

Published
2020
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77. IL-1β enhances human placenta-derived mesenchymal stromal cells ability to mediate Th1/Th2 and Th1/CD4+IL-10+ T cell balance and regulates its adhesion, proliferation and migration via PD-L1

Author

Zhang, Aiping, primary, Xiong, Yanlian, additional, Xu, Fenghuang, additional, Wang, Zhuoya, additional, Ma, Junjie, additional, Zhao, Nannan, additional, Hu, Tao, additional, Yi, Junzhu, additional, Zhou, Yuming, additional, and Luan, Xiying, additional

Published
2020
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80. Human placenta derived mesenchymal stromal cells alleviate GVHD by promoting the generation of GSH and GST in PD-1

Author

Wang Guoyan, Zhang Jiashen, Dong Menghua, Zhang Aiping, Wang Zhuoya, Zhao Nannan, Xiong Yanlian, and Luan Xiying

Subjects
0301 basic medicine, Adult, China, T cell, CD3, Placenta, T-Lymphocytes, Immunology, Programmed Cell Death 1 Receptor, Graft vs Host Disease, Spleen, Inflammation, Flow cytometry, 03 medical and health sciences, chemistry.chemical_compound, Interferon-gamma, Mice, 0302 clinical medicine, Pregnancy, medicine, Animals, Humans, Cells, Cultured, Glutathione Transferase, Mice, Inbred BALB C, biology, medicine.diagnostic_test, Mesenchymal stem cell, Cell Differentiation, Mesenchymal Stem Cells, Glutathione, Flow Cytometry, Molecular biology, Interleukin-10, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Glutathione S-transferase, chemistry, biology.protein, Female, medicine.symptom, 030215 immunology
Abstract

Aims To investigate whether placenta-derived mesenchymal stromal cells (hPMSCs) have immunoregulatory effects on PD-1+ T cell generation by controlling ROS production and thus alleviating GVHD. Main methods Flow cytometry was used to analyze the percentage of PD-1+ T cells, as well as the generation of ROS, GSH and GST in PD-1+ T cells. The expression of GST in the spleen and liver was analyzed by western blotting. Key findings The percentage of PD-1+ T cells was increased, but the ratio of GSH/GSSG was decreased in GVHD patients and the GVHDhigh mouse model compared with that in the normal control group. hPMSCs downregulated the level of malondialdehyde (MDA) and upregulated the ratio of GSH/GSSG and the expression of glutathione S transferase (GST) in the plasma, spleen and liver of GVHD mice compared with those of PBS-treated GVHD mice. Further studies showed that the ROS level, as well as the expression of PD-1, in both CD3+ and CD4+ T cells from the spleen and liver of hPMSC-treated GVHD mice were decreased compared with those observed in PBS-treated mice. Significance hPMSCs downregulated ROS generation by increasing GSH and GST levels and further reduced the expression of PD-1 on T cells, thereby alleviating inflammation in GVHD mice.

Published
2019

81. WITHDRAWN: IFN-γ and IL-1β treated-human placenta-derived mesenchymal stromal cells enhance the generation of IL-10+T cells by upregulating PDLs expressions and ameliorate experimental autoimmune encephalomyelitis

Author

Wang, Zhuoya, primary, Wang, Zhuoya, additional, Wang, Weiwei, additional, Hou, Yun, additional, Zhang, Aiping, additional, Wang, Guoyan, additional, Yi, Junzhu, additional, Fu, Qiang, additional, and Luan, Xiying, additional

Published
2018
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84. Cobalt Nanoparticles and Atomic Sites in Nitrogen‐Doped Carbon Frameworks for Highly Sensitive Sensing of Hydrogen Peroxide

Author

Li, Zehui, primary, Liu, Rongji, additional, Tang, Cheng, additional, Wang, Zhuoya, additional, Chen, Xiao, additional, Jiang, Yuheng, additional, Wang, Chizhong, additional, Yuan, Yi, additional, Wang, Wenbo, additional, Wang, Dongbin, additional, Chen, Shuning, additional, Zhang, Xiaoyuan, additional, Zhang, Qiang, additional, and Jiang, Jingkun, additional

Published
2019
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86. Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling

Author

Zhang, Lei, primary, Song, Qiaoling, additional, Zhang, Xinxin, additional, Li, Li, additional, Xu, Ximing, additional, Xu, Xiaohan, additional, Li, Xiaoyu, additional, Wang, Zhuoya, additional, Lin, Yuxi, additional, Li, Xin, additional, Li, Mengyuan, additional, Su, Fan, additional, Wang, Xin, additional, Qiu, Peiju, additional, Guan, Huashi, additional, Tang, Yu, additional, Xu, Wenfang, additional, Yang, Jinbo, additional, and Zhao, Chenyang, additional

Published
2019
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87. IL-27 Promotes Human Placenta–Derived Mesenchymal Stromal Cell Ability To Induce the Generation of CD4+IL-10+IFN-γ+ T Cells via the JAK/STAT Pathway in the Treatment of Experimental Graft-versus-Host Disease

Author

Yi, Junzhu, primary, Chen, Zhenghua, additional, Xu, Fenghuang, additional, Wang, ZhuoYa, additional, Zhang, Aiping, additional, Liu, Tongshen, additional, Zhao, Nannan, additional, Xiong, Yanlian, additional, Jiang, Guosheng, additional, Ma, Junjie, additional, and Luan, Xiying, additional

Published
2019
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89. hPMSCs inhibit the expression of PD-1 in CD4+IL-10+ T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.

Author

Zhang, Aiping, Zhang, Jiashen, Li, Xiaohua, Zhang, Hengchao, Xiong, Yanlian, Wang, Zhuoya, Zhao, Nannan, Wang, Feifei, and Luan, Xiying

Subjects
T cells, LABORATORY mice, LIVER cells, PROGRAMMED cell death 1 receptors, ANIMAL disease models, GRAFT versus host disease
Abstract

Background: The activation of T cells and imbalanced redox metabolism enhances the development of graft-versus-host disease (GVHD). Human placenta-derived mesenchymal stromal cells (hPMSCs) can improve GVHD through regulating T cell responses. However, whether hPMSCs balance the redox metabolism of CD4+IL-10+ T cells and liver tissue and alleviate GVHD remains unclear. This study aimed to investigate the effect of hPMSC-mediated treatment of GVHD associated with CD4+IL-10+ T cell generation via control of redox metabolism and PD-1 expression and whether the Nrf2 and NF-κB signaling pathways were both involved in the process. Methods: A GVHD mouse model was induced using 6–8-week-old C57BL/6 and Balb/c mice, which were treated with hPMSCs. In order to observe whether hPMSCs affect the generation of CD4+IL-10+ T cells via control of redox metabolism and PD-1 expression, a CD4+IL-10+ T cell culture system was induced using human naive CD4+ T cells. The percentage of CD4+IL-10+ T cells and their PD-1 expression levels were determined in vivo and in vitro using flow cytometry, and Nrf2, HO-1, NQO1, GCLC, GCLM, and NF-κB levels were determined by western blotting, qRT-PCR, and immunofluorescence, respectively. Hematoxylin-eosin, Masson's trichrome, and periodic acid-Schiff staining methods were employed to analyze the changes in hepatic tissue. Results: A decreased activity of superoxide dismutase (SOD) and a proportion of CD4+IL-10+ T cells with increased PD-1 expression were observed in GVHD patients and the mouse model. Treatment with hPMSCs increased SOD activity and GCL and GSH levels in the GVHD mouse model. The percentage of CD4+IL-10+ T cells with decreased PD-1 expression, as well as Nrf2, HO-1, NQO1, GCLC, and GCLM levels, both in the GVHD mouse model and in the process of CD4+IL-10+ T cell generation, were also increased, but NF-κB phosphorylation and nuclear translocation were inhibited after treatment with hPMSCs, which was accompanied by improvement of hepatic histopathological changes. Conclusions: The findings suggested that hPMSC-mediated redox metabolism balance and decreased PD-1 expression in CD4+IL-10+ T cells were achieved by controlling the crosstalk between Nrf2 and NF-κB, which further provided evidence for the application of hPMSC-mediated treatment of GVHD. [ABSTRACT FROM AUTHOR]

Published
2021
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90. Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3.

Author

Sun, Jingjie, Du, Yuping, Zhang, Xinxin, Wang, Zhuoya, Lin, Yuxi, Song, Qiaoling, Wang, Xiao, Guo, Jihui, Li, Shanshan, Nan, Jing, and Yang, Jinbo

Subjects
ANTINEOPLASTIC agents, APOPTOSIS, CELL cycle, CELL lines, CELLULAR signal transduction, DRUG design, CLINICAL drug trials, NEUROTRANSMITTER uptake inhibitors, PHOSPHORYLATION, STAT proteins, JANUS kinases, PHARMACODYNAMICS
Abstract

Summary: The Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway plays a vital role in immunity, cell division, cell death and tumor formation. Disrupted JAK-STAT signaling may lead to various diseases, especially cancer and immune disorders. Because of its importance, this signaling pathway has received significant attention from the pharmaceutical and biotechnology industries as a therapeutic target for drug design. However, few JAK or STATs inhibitors have been developed for cancer treatment. We used an in vitro STAT3 luciferase reporter assay to find novel inhibitors that could effectively block the JAK-STAT pathway. In our study, we screened 16,081 drug-like chemicals and found that atopaxar hydrobromide (AHB) is a specific inhibitor of JAK-STAT3 signaling. Our results suggest that AHB not only blocks constitutively activated and cytokine-induced STAT3 phosphorylation but also inhibits JAK1 and JAK2 phosphorylation. Moreover, AHB induces G1 phase cell cycle arrest, which stops cancer cell growth and induces apoptosis. AHB also inhibited tumor cell growth in vivo. In conclusion, AHB is a potential inhibitor that could be developed as a JAK-STAT pathway drug. [ABSTRACT FROM AUTHOR]

Published
2020
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95. Emerging investigator series: dispersed transition metals on a nitrogen-doped carbon nanoframework for environmental hydrogen peroxide detection

Author

Li, Zehui, primary, Jiang, Yuheng, additional, Liu, Chenming, additional, Wang, Zhuoya, additional, Cao, Zhiqin, additional, Yuan, Yi, additional, Li, Mingjie, additional, Wang, Yaling, additional, Fang, Daliang, additional, Guo, Zhuang, additional, Wang, Dongbin, additional, Zhang, Guangjin, additional, and Jiang, Jingkun, additional

Published
2018
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100. Effects of Cd- and Pb-resistant endophytic fungi on growth and phytoextraction of Brassica napus in metal-contaminated soils.

Author

Shi, Yanan, Xu, Zaichao, Wang, Zhuoya, Deng, Zujun, Xie, Huarong, Cao, Lixiang, and Zhang, Renduo

Subjects
RUTABAGA, ENDOPHYTIC fungi, CADMIUM, PHYTOREMEDIATION, SOIL pollution
Abstract

Metal-resistant endophytic fungi from roots improved phytoremediation efficacy of host plants; however, the effects of endophytic fungi from plant aerial parts on host plants are unknown. The aim of this study was to develop a feasible method to screen fungal endophytes from stems and roots of Brassica napus and to investigate effects of the endophytic fungi on growth and phytoremediation efficiency of the plant. Endophytic Fusarium sp. CBRF44, Penicillium sp. CBRF65, and Alternaria sp. CBSF68 with different traits were isolated from roots and stems of rapes grown in a metal-contaminated soil. Fusarium sp. CBRF44 (resistant to 5 mM Cd and 15 mM Pb, isolated from roots) and Alternaria sp. CBSF68 (resistant to 1 mM Cd and 10 mM Pb, isolated from stems) could produce indole-3-acetic acid (IAA) and siderophore; Penicillium sp. CBRF65 (tolerate 2 mM Cd and 20 mM Pb, isolated from roots) could not produce IAA and siderophore but showed the highest phosphate-solubilizing activities. Fusarium sp. CBRF44 and Penicillium sp. CBRF65 significantly increased the rape biomass and promoted the extraction efficacy of Pb and Cd, while Alternaria sp. CBSF68 did not show similar results. Penicillium sp. CBRF65 and Fusarium sp. CBRF44 could be frequently recovered from inoculated rape roots, while Alternaria sp. CBSF68 was scarcely recovered. The results indicate that the colonizing capacity of endophytic fungi in roots is important to improve phytoremediation efficacy of host plants. [ABSTRACT FROM AUTHOR]

Published
2017
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