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Objective: To systematically evaluate the association between MCP-1 gene-2518 A/G polymorphism and diabetic retinopathy (DR). Methods: CNKI, WanFang Data, and PubMed databases were searched. Studies on the correlation between MCP - 1 gene - 2518A /G polymorphism and DR were searched from inception until March 2022. Meta-analysis was performed using Revman5.3 software. Results: Seven studies were included. Meta-analysis showed that MCP-1 gene 2518A/G was not associated with the risk of DR in allelic and homozygous genetic models [G vs. A: OR=1.09, 95%CI (0.77, 1.54), P=0.62; GG vs. AA: OR=1.64, 95%CI (0.93, 2.88), P=0.09], and it was correlated with the risk of DR in heterozygous, dominant and recessive genetic models [GG vs. AG: OR=1.13, 95%CI (1.01, 1.26), P=0.03; AA+AG vs. GG: OR=0.85, 95%CI (0.77, 0.94), P=0.002; AA vs. GG+AG: OR=0.78, 95%CI (0.67, 0.90), P=0.0008]. According to the severity of DR, further meta-analysis of proliferative diabetic retinopathy (PDR)and nonproliferative diabetic retinopathy (NPDR) patients showed that there was no correlation between MCP-1 gene -2518A/G polymorphism and the risk of PDR in five genetic models [G vs. A: OR=1.06, 95%CI (0.80, 1.41), P=0.68; GG vs. AA: OR=1.12, 95%CI (0.77, 1.61), P=0.56; GG vs. AG: OR=0.88, 95%CI (0.69, 1.12), P=0.31; AA+AG vs. GG: OR=1.08, 95%CI (0.86, 1.36), P=0.50; AA vs. GG+AG: OR=0.73, 95%CI (0.49, 1.08), P=0.12]. Conclusion: MCP-1 gene 2518A/G polymorphism may be associated with the pathogenesis of DR, but it may not be involved in the progression of DR patients from NPDR to PDR. [ABSTRACT FROM AUTHOR]

Traditional testing method of mine-used equipment on/off transducer needs three-phase AC power supply and electric fires or bulbs with large power to get current for transducer acting, which cannot get continuously adjustable current with complex wiring and low efficiency. For above problems, the paper proposed a design scheme of test tooling of mine-used equipment on/off transducer, gave design demands, and introduced composition and main circuits of the test tooling in details. The testing result of a mine-used equipment on/off transducer showed that the test tooling can generate continuously adjustable current with simple and efficient operation, and can be calibrated through qualified clamp meter for correctness and traceability of testing data.

Objective: To investigate the association between the development of diabetic retinopathy and OCTA blood flow density. Methods: A total of 63 patients (100 eyes) diagnosed with type 2 diabetes in Eye Hospital of China Academy of Chinese Medical Sciences from September 2020 to July 2021 were selected, including 44 patients (72 eyes) with diabetic retinopathy and 19 patients (28 eyes) with type 2 diabetes without retinopathy (NDR). All patients underwent OCTA examination, and FAZ, PERIM, AI, FD,SVD, DVD and other indicators were counted. Results: (1)SVD,parafoveal SVD, DVD and parafoveal DVD gradually decreased with the progression of DR (P=0.000). There was no significant difference in SVD and DVD fovea(P>0.05).(2)The correlation coefficients between SVD, SVD, DVD, DVD and DR process were -0.525, -0.586, -0.323, -0.424, respectively(P<0.05), and all showed moderate negative correlation.(3)AI and FD gradually decreased with the progression of DR, and the differences were statistically significant (P=0.011, P=0.000), while FAZ and PERIM showed no significant difference with the progression of DR (P>0.05). (4)The correlation coefficients of FAZ, PERIM and DR progression were: -0.031, 0.084 (P>0.05), no correlation, AI, FD and DR process correlation coefficient were 0.307, -0.459 (P<0.05), respectively, were moderately positive and negative correlation; (5)The correlation coefficients of FAZ, PERIM, AI, FD and age were -0.124, -0.052, 0.113, -0.170 (P>0.05), respectively. Conclusion: There is a moderate correlation between the progression of DR and the superficial and deep blood flow density of OCTA. It was moderately correlated with AI and FD. OCTA can assist in the assessment of DR disease progression. [ABSTRACT FROM AUTHOR]