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92 results on '"Wan, Bingbing"'

59. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

Author

Huang, Jing, Gurung, Buddha, Wan, Bingbing, Matkar, Smita, Veniaminova, Natalia A., Wan, Ke, Merchant, Juanita L., Hua, Xianxin, and Lei, Ming

Subjects
Tumor proteins -- Physiological aspects -- Research, Leukemia -- Risk factors -- Genetic aspects -- Research, Genetic transcription -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Menin is a tumour suppressor protein whose loss or inactivation causes multiple endocrine neoplasia 1 (MEN1), a hereditary autosomal dominant tumour syndrome that is characterized by tumorigenesis in multiple endocrine organs (1). Menin interacts with many proteins and is involved in a variety of cellular processes (2-8). Menin binds the JUN family transcription factor JUND and inhibits its transcriptional activity (2,9). Several MEN1 missense mutations disrupt the menin-JUND interaction, suggesting a correlation between the tumour-suppressor function of menin and its suppression of JUND-activated transcription (2,10). Menin also interacts with mixed lineage leukaemia protein 1 (MLL1), a histone H3 lysine 4 methyl-transferase, and functions as an oncogenic cofactor to upregulate gene transcription and promote MLL1-fusion-protein-induced leukaemogenesis (5,7,11,12). A recent report on the tethering of MLL1 to chromatin binding factor lens epithelium-derived growth factor (LEDGF) by menin indicates that menin is a molecular adaptor coordinating the functions of multiple proteins (13). Despite its importance, how menin interacts with many distinct partners and regulates their functions remains poorly understood. Here we present the crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1-LEDGF heterodimer. These structures show that menin contains a deep pocket that binds short peptides of MLL1 or JUND in the same manner, but that it can have opposite effects on transcription. The menin-JUND interaction blocks JUN N-terminal kinase (JNK)-mediated JUND phosphorylation and suppresses JUND-induced transcription. In contrast, menin promotes gene transcription by binding the transcription activator MLL1 through the peptide pocket while still interacting with the chromatin-anchoring protein LEDGF at a distinct surface formed by both menin and MLL1., The amino-terminal region of MLL1 interacts with menin (12,14,15). Isothermal titration calorimetry measurements showed that the menin-binding motif (residues 6-25) of MLL1 (MLL1MBM) is necessary and sufficient for menin binding [...]

Published
2012
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66. Recovery of high-grade copper from metal-rich particles of waste printed circuit boards by ball milling and sieving.

Author

Liu, Fangfang, Chen, Weiping, Wan, Bingbing, Chen, Huanda, Ling, Zicheng, Chen, Zhiping, and Fu, Zhiqiang

Subjects
PRINTED circuits, BALL mills, COPPER-tin alloys, COPPER, METAL tailings, SIEVES, X-ray diffraction
Abstract

In this paper, a method of ball milling and sieving is proposed for recovery of high-grade copper from waste printed circuit boards (WPCBs). The effects of the milling time on the metals grade and recovery of the Cu, Sn and Pb during mechanical treatment were investigated. The results showed that, after 3 cycles of ball milling and sieving, the content of Cu was enriched to 94.72 wt.% from the initial 74.22 wt.% with a high recovery rate of 86.78%. Moreover, the contents of Sn and Pb were enriched to 28.27 wt.% and 18.86 wt.% from 10.13 wt.% and 6.63 wt.% in the by-products, respectively. However, excessive grinding occurred when the milling time was longer than 3 h and led to a sharp decrease in Cu recovery. The X-ray diffraction (XRD) patterns indicated that the metal phases mainly comprised pure Cu, Sn, Pb in the WPCB particles, while a Cu-Sn alloy was formed during the milling process, and the Cu-Sn alloy was also enriched in the tailings. The results presented here establish that ball milling and sieving is an alternative approach to recovering high-grade copper from WPCBs. [ABSTRACT FROM AUTHOR]

Published
2022
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73. Changing the Apoptosis Pathway through Evolutionary Protein Design

Author

Shultis, David, primary, Mitra, Pralay, additional, Huang, Xiaoqiang, additional, Johnson, Jarrett, additional, Khattak, Naureen Aslam, additional, Gray, Felicia, additional, Piper, Clint, additional, Czajka, Jeff, additional, Hansen, Logan, additional, Wan, Bingbing, additional, Chinnaswamy, Krishnapriya, additional, Liu, Liu, additional, Wang, Mi, additional, Pan, Jingxi, additional, Stuckey, Jeanne, additional, Cierpicki, Tomasz, additional, Borchers, Christoph H., additional, Wang, Shaomeng, additional, Lei, Ming, additional, and Zhang, Yang, additional

Published
2019
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76. Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates

Author

Bonner, Jacob N., primary, Choi, Koyi, additional, Xue, Xiaoyu, additional, Torres, Nikko P., additional, Szakal, Barnabas, additional, Wei, Lei, additional, Wan, Bingbing, additional, Arter, Meret, additional, Matos, Joao, additional, Sung, Patrick, additional, Brown, Grant W., additional, Branzei, Dana, additional, and Zhao, Xiaolan, additional

Published
2016
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90. Effects of trace ytterbium addition on microstructure, mechanical and thermal properties of hypoeutectic Al-5Ni alloy

Author

Wang, Kang, Hu, Shaodong, Zhong, Yanglin, Jin, Shuoxun, Zhou, Zirong, Wang, Zhiyu, Chen, Jiongcai, Wan, Bingbing, and Li, Wenfang

Abstract

Over the past decade, the cast aluminum alloys with excellent mechanical and conductivity properties have emerged as potential materials for thermal management. However, the traditional Al-Si based alloys are difficult to make significant breakthroughs in conductivity performance. The hypoeutectic Al-5Ni alloy also possesses sound castability and is expected to be applied in thermal management applications. In this study, the effects of ytterbium (Yb element) at 0.0–0.5 wt% on the microstructures as well as the electrical/thermal conductivity and mechanical properties of the Al-5Ni alloy was systematically investigated. The experimental results indicate that the addition of Yb at a relatively low amount not only reduces the secondary dendrite arm spacing of the α-Al grains, but also modifies the morphology and distribution of eutectic boundary phase. Moreover, it is found that the dosage of Yb at 0.3 wt% in the Al-5Ni alloy can simultaneously improve the yield strength, ultimate tensile strength and electrical/thermal conductivity. The strengthening and toughening of the Al-5Ni alloy are mainly attributed to the decrease of secondary dendrite arm spacing and the improvement of eutectic phases. The TEM/SAED analysis indicates that the ytterbium in Al-5Ni alloy would form Al3Yb phase, which mainly agglomerates in the Al3Ni phase region. This phase is helpful to decrease the solubility of impurity elements (e.g., Fe and Si) in the α-Al matrix, which is beneficial to electrical/thermal conductivity. The value of this study lays foundation for manufacturing Al-Ni alloys with high thermal conductivity and acceptable mechanical properties.

Published
2021
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92. The Mms22-Rtt107 axis dampens the DNA damage checkpoint by reducing the stability of the Rad9 checkpoint mediator.

Author

Zhao X, Wan B, Guan D, Li S, and Chwat-Edelstein T

Abstract

The DNA damage checkpoint is a highly conserved signaling pathway induced by genotoxin exposure or endogenous genome stress. It alters many cellular processes such as arresting the cell cycle progression and increasing DNA repair capacities. However, cells can downregulate the checkpoint after prolonged stress exposure to allow continued growth and alternative repair. Strategies that can dampen the DNA damage checkpoint are not well understood. Here, we report that budding yeast employs a pathway composed of the scaffold protein Rtt107, its binding partner Mms22, and an Mms22-associated ubiquitin ligase complex to downregulate the DNA damage checkpoint. Mechanistically, this pathway promotes the proteasomal degradation of a key checkpoint factor, Rad9. Furthermore, Rtt107 binding to Mms22 helps to enrich the ubiquitin ligase complex on chromatin and target the chromatin-bound form of Rad9. Finally, we provide evidence that the Rtt107-Mms22 axis operates in parallel with the Rtt107-Slx4 axis, which displaces Rad9 from chromatin. We thus propose that Rtt107 enables a bifurcated "anti-Rad9" strategy to optimally downregulate the DNA damage checkpoint., Competing Interests: DECLARATION OF INTERESTS. The authors declare no competing interests.

Published
2024
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