408 results on '"Wallet, Florent"'
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52. Additional file 1 of ICU admission for solid cancer patients treated with immune checkpoint inhibitors
- Author
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Toffart, Anne-Claire, Meert, Anne-Pascale, Wallet, Florent, Gibelin, Aude, Guisset, Olivier, Gonzalez, Frédéric, Seguin, Amélie, Kouatchet, Achille, Delaunay, Myriam, Debieuvre, Didier, Duchemann, Boris, Rousseau-Bussac, Gaëlle, Nyunga, Martine, Grimaldi, David, Levrat, Albrice, Azoulay, Elie, and Lemiale, Virginie
- Abstract
Additional file 1: Table S1. World Health Organization-Uppsala Monitoring Centre (WHO-UMC) causality categories. Table S2. Diagnosis at ICU admission according to proposed IrAE causality at ICU discharge (n = 110 patients).
- Published
- 2023
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53. Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study
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Azoulay, Elie, Pickkers, Peter, Soares, Marcio, Perner, Anders, Rello, Jordi, Bauer, Philippe R., van de Louw, Andry, Hemelaar, Pleun, Lemiale, Virginie, Taccone, Fabio Silvio, Martin Loeches, Ignacio, Meyhoff, Tine Sylvest, Salluh, Jorge, Schellongowski, Peter, Rusinova, Katerina, Terzi, Nicolas, Mehta, Sangeeta, Antonelli, Massimo, Kouatchet, Achille, Barratt-Due, Andreas, Valkonen, Miia, Landburg, Precious Pearl, Bruneel, Fabrice, Bukan, Ramin Brandt, Pène, Frédéric, Metaxa, Victoria, Moreau, Anne Sophie, Souppart, Virginie, Burghi, Gaston, Girault, Christophe, Silva, Ulysses V. A., Montini, Luca, Barbier, François, Nielsen, Lene B., Gaborit, Benjamin, Mokart, Djamel, Chevret, Sylvie, Rabbat, Antoine, Vinatier, Isabelle, Darmon, Michael, Klouche, Kada, Platon, Laura, Platon, Laura, Demoule, Alexandre, Mayaux, Julien, Wallet, Florent, Chermak, Akli, Lemaitre, Caroline, Artaud-Macari, Elise, Nelsen, Jonas, Moeller, Ann M., Kaufmann, Thomas, Bergmans, Dennis, Spoelstra de Man, Angélique, de Moraes, Ana Paula Pierre, Viana, William, Moralez, Guilliana, Lishoa, Thiago, Encina, Belen, Moreno, Gabriel, Luis, Emilio Rodriguez, Crespi, Llorenç Socias, Hemang, Yadav, Meert, Anne-Pascale, Benoit, Dominique, Buchtele, Nina, Staudinger, Thomas, Heinz, Gottfried, Sengölge, Gürkan, Zauner, Christian, Jaksch, Peter, Amrein, Karin, McMahon, Aisling, Marsh, Brian, Martin, Balik, Thomas, Karvunidis, Klepstad, Pål, Kuitunen, Anne, Cinnella, Gilda, Cotoia, Antonella, Shah, Sumech, and for the Efraim investigators and the Nine-I study group
- Published
- 2017
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54. Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries
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Kahan, Brennan C., Koulenti, Desponia, Arvaniti, Kostoula, Beavis, Vanessa, Campbell, Douglas, Chan, Matthew, Moreno, Rui, Pearse, Rupert M., Pearse, Rupert M., Beattie, Scott, Clavien, Pierre-Alain, Demartines, Nicolas, Fleisher, Lee A., Grocott, Mike, Haddow, James, Hoeft, Andreas, Holt, Peter, Moreno, Rui, Pritchard, Naomi, Rhodes, Andrew, Wijeysundera, Duminda, Wilson, Matt, Ahmed, Tahania, Everingham, Kirsty, Hewson, Russell, Januszewska, Marta, Pearse, Rupert M., Phull, Mandeep-Kaur, Halliwell, Richard, Shulman, Mark, Myles, Paul, Schmid, Werner, Hiesmayr, Michael, Wouters, Patrick, de Hert, Stefan, Lobo, Suzana, Beattie, Scott, Wijeysundera, Duminda, Fang, Xiangming, Rasmussen, Lars, Futier, Emmanuel, Biais, Matthieu, Venara, Aurélien, Slim, Karem, Sander, Michael, Koulenti, Despoina, Arvaniti, Kostoula, Chan, Mathew, Kulkarni, Atul, Chandra, Susilo, Tantri, Aida, Geddoa, Emad, Abbas, Muntadhar, Della Rocca, Giorgio, Sivasakthi, Datin, Mansor, Marzida, Luna, Pastor, Bouwman, Arthur, Buhre, Wolfgang, Beavis, Vanessa, Campbell, Douglas, Short, Tim, Osinaike, Tunde, Matos, Ricardo, Grigoras, Ioana, Kirov, Mikhail, Protsenko, Denis, Biccard, Bruce, Aldecoa, Cesar, Chew, Michelle, Hofer, Christoph, Hubner, Martin, Ditai, James, Szakmany, Tamas, Fleisher, Lee, Ferguson, Marissa, MacMahon, Michael, Shulman, Mark, Cherian, Ritchie, Currow, Helen, Kanathiban, Kathirgamanathan, Gillespie, David, Pathmanathan, Edward, Phillips, Katherine, Reynolds, Jenifer, Rowley, Joanne, Douglas, Jeanene, Kerridge, Ross, Currow, Helen, Garg, Sameer, Bennett, Michael, Jain, Megha, Alcock, David, Terblanche, Nico, Cotter, Rochelle, Leslie, Kate, Stewart, Marcelle, Zingerle, Nicolette, Clyde, Antony, Hambidge, Oliver, Rehak, Adam, Cotterell, Sharon, Binh QuanHuynh, Wilson, McCulloch, Timothy, Ben-Menachem, Erez, Egan, Thomas, Cope, Jennifer, Halliwell, Richard, Fellinger, Paul, Haselberger, Simone, Holaubek, Caroline, Lichtenegger, Paul, Scherz, Florian, Schmid, Werner, Hoffer, Franz, 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Lam, Tracy, Chu, Susanna, Lai, Man Ling, Lam, Wing Yan, Wong, Kin Wai Kevin, Kwok, Dilys, Hung, Ching Yue Janice, Chan, Wai Kit Jacky, LamWong, Wing, Chung, Chun Kwong Eric, Lai, Man Ling, Ma, ShuKai, Kaushik, Shuchi, Shah, Bhagyesh, Shah, Dhiren, Shah, Sanjay, Ar, Praburaj, Muthuchellappan, Radhakrishnan, Agarwal, Vandana, Divatia, Jigeeshu, Kulkarni, Atul, Mishra, Sanghamitra, Nimje, Ganesh, Pande, Swati, Savarkar, Sukhada, Shrivastava, Aditi, Thomas, Martin, Yegnaram, Shashikant, Hidayatullah, Rahmat, Chandra, Susilo, Tantri, Aida, Puar, Nasman, Niman, Sumara, Indra, Imai, Hamzah, Zulkarnain, Yuliana, Annika, Abidin, Ucu Nurhadiat, Dursin, Ade Nurkacan, Kurnia, Andri, Susanti, Ade, Handayani, Dini, Aribawa, Mahaalit Alit, Arya, Aryabiantara, Senapathi, Tjokorda Gde Agung, Utara, Utara Hartawan, Wid, Widnyana Made, Wima, Semarawima, Wir, Wiryana Made, Jehosua, Brillyan, Kaunang, Jonathan, Lantang, Eka Yudha, Najoan, Rini, Waworuntu, Neil, Awad, Hadi, Fuad, Akram, Geddoa, Emad, Geddoa, Burair, Khalaf, Abdel Razzaq, Al hussaini, Sabah, Albaj, Safauldeensalem, Kenber, Maithem, Bettinelli, Alessandra, Spadaro, Savino, Volta, Carlo Alberto, Giancarlo, Luigi, Sottosanti, Vicari, Della Rocca, Giorgio, Spagnesi, Lorenzo, Toretti, Ilaria, Alloj, Chiara, Cardellino, Silvano, Carmino, Livio, Costanzo, Eleonora, Fanfani, Lucia Caterina, Novelli, Maria Teresa, Roasio, Agostino, Bellandi, Mattia, Beretta, Luigi, Bignami, Elena, Bocchino, Speranza, Cabrini, Luca, Corti, Daniele, Landoni, Giovanni, Meroni, Roberta, Moizo, Elena, Monti, Giacomo, Pintaudi, Margherita, Plumari, Valentina Paola, Taddeo, Daiana, Testa, Valentina, Winterton, Dario, Zangrillo, Alberto, Cloro, Luigi Maria, Colangelo, Chiara, Colangelo, Antonio, Rotunno, Giuseppe, Angel, MiguelPaludi, Maria, Cloro Paolo, Pata, Antonio, Parrini, Vieri, Gatta, Alessandro, Nastasi, Mauro, Tinti, Carla, Spagnesi, Lorenzo, Arrigo, Mario, Benevento, Angelo, Bottini, Corrado, Cannavo’, Maurizio, Gastaldi, Christian, 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Husni Zaeem, Ahmad Azam, Ummi Azmira, Alias, Abdul Hafiz, Kesut, Saiful Aizar, Lee, Jun May, Ooi, Dar Vin, Sulaiman, Hetty Ayuni, Tengku Lih, Tengku Alini, Mansor, Marzida, Veerakumaran, Jeyaganesh, Luna, Pastor, Rojas, Eder, Resendiz, Gerardo Esteban Alvarez, Zapata, Darcy Danitza Mari, Aguilar López, Julio Cesar Jesús, Flores, Armando Adolfo Alvarez, Amador, Juan Carlosc Bravo, Avila, Erendira Jocelin Dominguez, Aquino, Laura Patricia González, Rodriguez, Ricardo Lopez, Landa, Mariana Torres, Urias, Emma, Hollmann, Markus, Hulst, Abraham, Kirzner, Osne, Preckel, Benedikt, Koopman-van Gemert, Ankie, Bouwman, Arthur, Buise, Marc, Tolenaar, Noortje, Weber, Eric, de Fretes, Jennifer, Houweling, Peter, Ormskerk, Patricia, Van Bommel, Jasper, Buhre, Wolfgang, Lance, Marcus, Smit-Fun, Valerie, van Zundert, Tom, Baas, Peter, de Boer, Hans Donald, Sprakel, Joost, Elferink-Vonk, Renske, Noordzij, Peter, van Zeggeren, Laura, Brand, Bastiaan, spanjersberg, Rob, ten Bokkel-Andela, Janneke, Numan, 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Ikemefuna, Onuora, Elias, Onyeka, Tonia, Ugwu, Innocent, Umeh, Friday, Alagbe-Briggs, Olubusola, Dodiyi-Manuel, Amabra, Echem, Richard, Obasuyi, Bright, Onajin-Obembe, Bisola, Bandeira, Maria Expedito, Martins, Alda, Tomé, Miguel, Martins Costa, Ana Cristina Miranda, Krystopchuk, Andriy, Branco, Teresa, Esteves, Simao, Melo, Marco António, Monte, Júlia, Rua, Fernando, Martins, Isabel, Pinho-Oliveira, Vítor Miguel, Rodrigues, Carla Maria, Cabral, Raquel, Marques, Sofia, Rêgo, Sara, Teixeira Jesus, Joana Sofia, Conceição Marques, Maria, Romao, Cristina, Dias, Sandra, Santos, Ana Margarida, Alves, Maria Joao, Salta, Cristina, Cruz, Salome, Duarte, Célia, Furtado Paiva, António Armando, do Nascimento Cabral, Tiago, Fariae Maia, Dionisio, Correia da Silva, Rui Freitas Mendonça, Langner, Anuschka, Oliveira Resendes, Hernâni, da Conceição Soares, Maria, Abrunhosa, Alexandra, Faria, Filomena, Miranda, Lina, Pereira, Helena, Serra, Sofia, Ionescu, Daniela, Margarit, Simona, Mitre, Calin, 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Weatherall, Lucie, Weatherill, J., Whitman, Zoe, Wighton, Elinor, Abayasinghe, Chamika, Chan, Alexander, Darwish, Sharif, Gill, James, Glasgow, Emma, Hadfield, Daniel, Harris, Clair, Kochhar, Arun, Mellis, Clare, Pool, Andrew, Riozzi, Paul, Selman, Andrew, Smith, Emma-Jane, Vele, Liana, Gercek, Yuksel, Guy, Kramer, Holden, Douglas, Watson, Nicholas, Whysall, Karen, Andreou, Prematie, Hales, Dawn, Thompson, Jonathan, Bowrey, Sarah, McDonald, Shara, Thompson, Jonathan, Gilmore, Jemma, Hills, Vicky, Kelly, Chan, Kelly, Sinead, Lloyd, Geraint, Abbott, Tom, Gall, Lewis, Torrance, Hew, Vivian, Mark, Berntsen, Emer, Nolan, Tracey, Turner, Angus, Vohra, Akbar, Brown, Andrew, Clark, Richard, Coughlan, Elaine, Daniel, Conway, Patvardhan, Chinmay, Pearson, Rachel, Predeep, Sheba, Saad, Hesham, Shanmugam, Mohanakrishnan, Varley, Simon, Vohra, Akbar, Wylie, Katharine, Cooper, Lucy, Makowski, Arystarch, Misztal, Beata, Moldovan, Eliza, Pegg, Claire, Donovan, Andrew, Foot, Jayne, Large, Simon, Claxton, Andrew, Netke, Bhagyashree, Armstrong, Richard, Calderwood, Claire, Kwok, Andy, Mohr, Otto, Oyeniyi, Peter, Patnaik, Lisa, Post, Benjamin, Ali, Sarah, Arshad, Homa, Baker, Gerard, Brenner, Laura, Brincat, Maximilian, Brunswicker, Annemarie, Cox, Hannah, Cozar, Octavian Ionut, Durst, Alexander, Fengas, Lior, Flatt, Jim, Glister, Georgina, Narwani, Vishal, Photi, Evangelos, Rankin, Adeline, Rosbergen, Melissa, Tan, Mark, Beaton, Ceri, Horn, Rachel, Hunt, Jane, Rousseau, Guy, Stancombe, Lucia, Absar, Mohammed, Allsop, Joanne, Drinkwater, Zoe, Hodgkiss, Tracey, Smith, Kirsty, Brown, Jamie, Pick, Sara, Alexander-Sefre, Farhad, Campey, Lorraine, Dudgeon, Lucy, Hall, Kathryn, Hitchcock, Rachael, James, Lynne, Smith, Kate, Winstone, Ulrika, Ahmad, Norfaizan, Bauchmuller, Kris, Harrison, Jonathan, Jeffery, Holly, Miller, Duncan, Pinder, Angela, Pothuneedi, Sailaja, Rosser, Jonathan, Sanghera, Sumayer, Swift, Diane, Walker, Rachel, Bester, Delia, Cavanagh, Sarah, Cripps, Heather, Daniel, Harvey, Lynch, Julie, Paton, Alison, Pyke, Shirley, Scholefield, John, Whitworth, Helen, Bottrill, Fiona, Ramalingam, Ganesh, Webb, Stephen, Akerman, Nik, Antill, Philip, Bourner, Lynsey, Buckley, Sarah, Castle, Gail, Charles, Rob, Eggleston, Christopher, Foster, Rebecca, Gill, Satwant, Lindley, Kate, Lklouk, Mohamed, Lowery, Tracey, Martin, Oliver, Milne, David, O’Connor, Patrick, Ratcliffe, Andrew, Rose, Alastair, Simeson, Karen, Smith, Annie, Varma, Sandeep, Ward, Jackie, Simeson, Karen, Barcraft-Barnes, Helena, Camsooksai, Julie, Colvin, Carolyn, Reschreiter, Henrik, Tbaily, Lee, Venner, Nicola, Hamilton, Caroline, Kelly, Lewis, Toth-Tarsoly, Piroska, Dodsworth, Kerry, Foord, Denise, Gordon, Paul, Hawes, Elizabeth, Lamb, Nikki, Mouland, Johanna, Nightingale, Jeremy, Rose, Steve, Schrieber, Joe, Al ‘Amri, Khalid, Aladin, Hafiz, Arshad, Mohammed Asif, Barraclough, James, Bentley, Conor, Bergin, Colin, Carrera, Ronald, Clarkson, Aisling, Collins, Michelle, Cooper, Lauren, Denham, Samuel, Griffiths, Ewen, Ip, Peter, Jeyanthan, Somasundaram, Joory, Kavita, Kaur, Satwant, Marriott, Paul, Mitchell, Natalie, Nagaiah, Sukumar, Nilsson, Annette, Parekh, Nilesh, Pope, Martin, Seager, Joseph, Serag, Hosam, Tameem, Alifia, Thomas, Anna, Thunder, Joanne, Torrance, Andrew, Vohra, Ravinder, whitehouse, Arlo, Wong, Tony, Blunt, Mark, Wong, Kate, Giles, Julian, Reed, Isabelle, Weller, Debbie, Bell, Gillian, Birch, Julie, Damant, Rose, Maiden, Jane, Mewies, Clare, Prince, Claire, Radford, Jane, Balain, Birender, Banerjee, Robin, Barnett, Andrew, Burston, Ben, Davies, Kirsty, Edwards, Jayne, Evans, Chris, Ford, David, Gallacher, Pete, Hill, Simon, Jaffray, David, Karlakki, Sudheer, Kelly, Cormac, Kennedy, Julia, Kiely, Nigel, Lewthwaite, Simon, Marquis, Chris, Ockendon, Matthew, Phillips, Stephen, Pickard, Simon, Richardson, James, Roach, Richard, Smith, Tony, Spencer-Jones, Richard, Steele, Niall, Steen, Julie, Van Liefland, Marck, White, Steve, Faulds, Matthew, Harris, Meredyth, Kelly, Carrie, Nicol, Scott, Pearson, Sally Anne, Chukkambotla, Srikanth, Andrew, Alyson, Attrill, Elizabeth, Campbell, Graham, Datson, Amanda, Fouracres, Anna, Graterol, Juan, Graves, Lynne, Hong, Bosun, Ishimaru, Alexander, Karthikeyan, Arvind, King, Helen, Lawson, Tom, Lee, Gregory, Lyons, Saoirse, Macalister Hall, Andrew, Mathoulin, Sophie, Mcintyre, Eilidh, Mclaughlin, Danny, Mulcahy, Kathleen, Ratcliffe, Anna, Robbins, James, Sung, Weilin, Tayo, Adeoluwa, Trembath, Lisa, Venugopal, Suneetha, Walker, Robert, Wigmore, Geoffrey, Boereboom, Catherine, Downes, Charlotte, Humphries, Ryan, Melbourne, Susan, Smith, Coral, Tou, Samson, Ullah, Shafa, Batchelor, Nick, Boxall, Leigh, Broomby, Rupert, Deen, Tariq, Hellewell, Alistair, Helliwell, Laurence, Hutchings, Melanie, Hutchins, David, Keenan, Samantha, Mackie, Donna, Donna, Alison, Smith, Frances, Stone, Lucy, Thorpe, Kevin, Wassall, Richard, Woodgate, Andrew, Baillie, Shelley, Campbell, Tara, James, Sarah, King, Chris, Marques de Araujo, Daniela, Martin, Daniel, Morkane, Clare, Neely, Julia, Rajendram, Rajkumar, Burton, Megan, James, Kathryn, Keevil, Edward, Minik, Orsolya, Morgan, Jenna, Musgrave, Anna, Rajanna, Harish, Roberts, Tracey, Szakmany, Tamas, Adamson, Michael, Jumbe, Sandra, Kendall, Jennie, Muthuswamy, Mohan Babu, Anderson, Charlotte, Cruikshanks, Andrew, Pothuneedi, Sailaja, Walker, Rachel, Wrench, Ian, Zeidan, Lisa, Ardern, Diane, Harris, Benjamin, Hellstrom, Johanna, Martin, Jane, Thomas, Richard, Varsani, Nimu, Wrey Brown, Caroline, Docherty, Philip, Gillies, Michael, McGregor, Euan, Usher, Helen, Craig, Jayne, Smith, Andrew, Ahmad, Tahania, Bodger, Phoebe, Creary, Thais, Everingham, Kirsty, Fowler, Alexander, Hewson, Russ, Ijuo, Eke, Januszewska, Marta, Jones, Timothy, Kantsedikas, Ilya, Lahiri, Sumitra, McLean, Aaron Lawson, Niebrzegowska, Edyta, Phull, Mandeep, Wang, Difei, Wickboldt, Nadine, Baldwin, Jacqueline, Doyle, Donna, Mcmullan, Sean, Oladapo, Michelle, Owen, Thomas, Tripathi, Shiva, Williams, Alexandra, Daniel, Hull, Gregory, Peter, Husain, Tauqeer, Kirk-Bayley, Justin, Mathers, Edward, Montague, Laura, White, Stuart, Avis, Joanne, Cook, Tim, Dali-Kemmery, Lola, Kerslake, Ian, Lambourne, Victoria, Pearson, Annabel, Boyd, Christine, Callaghan, Mark, Lawson, Cathy, McCrossan, Roopa, Nesbitt, Vanessa, O’connor, Laura, Scott, Julia, Sinclair, Rhona, Farid, Nahla, Morgese, Ciro, Bhatia, Kailash, Karmarkar, Swati, Vohra, Akbar, Ahmed, Jamil, Branagan, Graham, Hutton, Monica, Swain, Andrew, Brookes, Jamie, Cornell, Jonathan, Dolan, Rachael, Hulme, Jonathan, Jansen van Vuuren, Amanda, Jowitt, Tom, Kalashetty, Gunasheela, Lloyd, Fran, Patel, Kiran, Sherwood, Nicholas, Brown, Lynne, Chandler, Ben, Deighton, Kerry, Emma, Temlett, Haunch, Kirsty, Cheeseman, Michelle, Dent, Kathy, Garg, Sanjeev, Gray, Carol, Hood, Marion, Jones, Dawn, Juj, Joanne, Mitra, Atideb, Rao, Roshan, Walker, Tara, Al Anizi, Mashel, Cheah, Clarissa, Cheing, Yushio, Coutinho, Francisco, Gondo, Prisca, Hadebe, Bernard, Onie Hove, Mazvangu, khader, Ahamed, Krishnachetty, Bobby, Rhodes, Karen, Sokhi, Jagdish, Baker, Katie-Anne, Bertram, Wendy, Looseley, Alex, Mouton, Ronelle, Arnold, Glenn, Arya, Shobhit, Balfoussia, Danai, Baxter, Linden, Harris, James, Jones, Craig, Knaggs, Alison, Markar, Sheraz, Perera, Anisha, Scott, Alasdair, Shida, Asako, Sirha, Ravneet, Wright, Sally, Frost, Victoria, Gray, Catherine, MacGregor, Mark, Andrews, Emma, Arrandale, Lindsay, Barrett, Stephen, Bidd, Heena, Cifra, Elna, Cooper, Mariese, Dragnea, Dragos, Elna, Cifra, Maclean, Jennifer, Meier, Sonja, Milliken, Donald, Munns, Christopher, Ratanshi, Nadir, Salvana, Abegail, Watson, Anthony, Ali, Hani, Campbell, Gill, Critchley, Rebecca, Hicks, Catherine, Liddle, Alison, Pass, Marc, Ritchie, Charlotte, Thomas, Charlotte, Too, Lingxi, Welsh, Sarah, Gill, Talvinder, Johnson, Joanne, Reed, Joanne, Davis, Edward, Papadopoullos, Sam, Attwood, Clare, Biffen, Andrew, Boulton, Kerenza, Gray, Sophie, Hay, David, Mills, Sarah, Montgomery, Jane, Riddell, Rory, Simpson, James, Bhardwaj, Neeraj, Paul, Elaine, Uwubamwen, Nosakhare, Vohra, Akbar, Berntsen, Emer, Nolan, Tracey, Turner, Angus, Alexander, Maini, Arrich, James, Arumugam, Swarna, Blackwood, Douglas, Boggiano, Victoria, Brown, Robyn, Lam Chan, Yik, Chatterjee, Devnandan, Chhabra, Ashok, Christian, Rachel, Costelloe, Hannah, CoxwellMatthewman, Madeline, Dalton, Emma, Darko, Julia, Davari, Maria, Dave, Tejal, Deacon, Matthew, Deepak, Shantal, Edmond, Holly, Ellis, Jessica, El-Sayed, Ahmed, Eneje, Philip, English, Rose, Ewe, Renee, Foers, William, Franklin, John, Gallego, Laura, Garrett, Emily, Goldberg, Olivia, Goss, Harry, Greaves, Rosanna, Harris, Rudy, Hennings, Charles, Jones, Eleanor, Kamali, Nelson, Kokkinos, Naomi, Lewis, Carys, Lignos, Leda, Malgapo, Evaleen Victoria, Malik, Rizwana, Milne, Andrew, Mulligan, John-Patrick, Nicklin, Philippa, Palipane, Natasha, Parsons, Thomas, Piper, Rebecca, Prakash, Rohan, Ramesh, Byron, Rasip, Sarah, Reading, Jacob, Rela, Mariam, Reyes, Anna, Robert, Stephens, Rooms, Martin, Shah, Karishma, Simons, Henry, Solanki, Shalil, Spowart, Emma, Stevens, Amy, Thomas, Christopher, Waggett, Helena, Yassaee, Arrash, Kennedy, Anthony, Scott, Sara, Somanath, Sameer, Berg, Andrew, Hernandez, Miguel, Nanda, Rajesh, Tank, Ghanshyambhai, Wilson, Natalie, Wilson, Debbie, Al-Soudaine, Yassr, Baldwin, Matthew, Cornish, Julie, Davies, Zoe, Davies, Leigh, Edwards, Marc, Frewer, Natasha, Gallard, Sian, Glasbey, James, Harries, Rhiannon, Hopkins, Luke, Kim, Taeyang, Koompirochana, Vilavan, Lawson, Simon, Lewis, Megan, Makzal, Zaid, Scourfield, Sarah, Ahmad, Yousra, Bates, Sarah, Blackwell, Clare, Bryant, Helen, Coulter, Suzanne, Cruickshank, Ross, Daniel, Sonya, Daubeny, Thomas, Edwards, Mark, Golder, Kim, Hawkins, Lesley, Helen, Bryant, Hinxman, Honor, Levett, Denny, Skinner, Ben, Walsgrove, Joseph, Bradburn, Mike, Dickson, Jane, Constantin, Kathryn, Karen, Markwell, O’Brien, Peter, O’Donohoe, Lynn, Payne, Hannah, Sundayi, Saul, Walker, Elaine, Brooke, Jenny, Cardy, Jon, Humphreys, Sally, Kessack, Laura, Kubitzek, Christiane, Kumar, Suhas, Cotterill, Donna, Hodzovic, Emil, Hosdurga, Gurunath, Miles, Edward, Saunders, Glenn, Campbell, Marta, Chan, Peter, Jemmett, Kim, Raj, Ashok, Naik, Aditi, Ramamoorthy, Rajarajan, Shah, Nimesh, Sylvan, Axel, Blyth, Katharine, Burtenshaw, Andrew, Freeman, David, Johnson, Emily, Lo, Philip, Martin, Terry, Plunkett, Emma, Wollaston, Julie, Allison, Joanna, Carroll, Christine, Craw, Nicholas, Craw, Sarah, Pitt-Kerby, Tressy, Rowland-Axe, Rebecca, Spurdle, Katie, McDonald, Andrew, Simon, Davies, Sinha, Vivek, Smith, Thomas, Banner-Goodspeed, Valerie, Boone, Myles, Campbell, Kathleen, Lu, Fengxin, Scannell, Joseph, Sobol, Julia, Balajonda, Naraida, Clemmons, Karen, Conde, Carlos, Funk, Bonita, Hall, Roger, Hopkins, Thomas, Olaleye, Omowunmi, Omer, Omer, Pender, Michelle, Porto, Angelo, Stevens, Alice, Waweru, Peter, Yeh, Erlinda, Bodansky, Daniella, Evans, Adam, Kleopoulos, Steven, Maril, Robert, Mathney, Edward, Sanchez, Angela, Tinuoye, Elizabeth, Bateman, Brian, Eng, Kristen, Jiang, Ning, Ladha, Karim, Needleman, Joseph, Chen, Lee-lynn, Chen, Lee-lynn, Lane, Rondall, Robinowitz, David, Ghushe, Neil, Irshad, Mariam, Patel, Samir, Takemoto, Steven, Wallace, Art, Mazzeffi, Michael, Rock, Peter, Wallace, Karin, Zhu, Xiaomao, Chua, Pandora, Fleisher, Lee, Mattera, Matthew, Sharar, Rebecca, Thilen, Stephan, Treggiari, Miriam, Morgan, Angela, Sofjan, Iwan, Subramaniam, Kathirvel, Avidan, Michael, Maybrier, Hannah, Muench, Maxwell, Wildes, Troy, and The International Surgical Outcomes Study (ISOS) group
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- 2017
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55. Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants
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Ader, Florence, Argaud, Laurent, Aubrun, Frédéric, Fellahi, Jean-Luc, Guichon, Céline, Juillard, Laurent, Leclerc, Vincent, Miossec, Charline, Paillet, Carole, Plesa, Alexandra, Richard, Jean-Christophe, Roux, Sandrine, Wallet, Florent, Bienvenu, A.L., Pradat, P., Matusik, E., Piriou, V., Rimmelé, T., Parant, F., Tod, M., Leboucher, G., and Goutelle, S.
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- 2023
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56. Tracheal stent aspergillosis occurring after aortic allograft of the trachea
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Durliat, Alix, primary, Locatelli‐Sanchez, Myriam, additional, Wallet, Florent, additional, and Allaouchiche, Bernard, additional
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- 2022
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57. Outcome in Multiple Myeloma Patients Treated in the Era of Modern Therapies Who Were Admitted to Intensive Care: A Retrospective Analysis from a Teaching Hospital between 2014 and 2019
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Gross, Zofia, primary, Idlhaj, Maryam, additional, Karlin, Lionel, additional, Friggeri, Arnaud, additional, Lazareth, Anne, additional, Golfier, Camille, additional, Lequeu, Helene, additional, Bouafia Sauvy, Fadhela, additional, Sesques, Pierre, additional, Safar, Violaine, additional, Ferrant, Emmanuelle, additional, Ghergus, Dana, additional, Maarek, Alizee, additional, Aussedat, Guillaume, additional, Salles, Gilles, additional, Bachy, Emmanuel, additional, Wallet, Florent, additional, and Ghesquieres, Herve, additional
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- 2022
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58. B-cell malignancies and COVID-19: a narrative review
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Luque-Paz, David, primary, Sesques, Pierre, additional, Wallet, Florent, additional, Bachy, Emmanuel, additional, and Ader, Florence, additional
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- 2022
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59. High-flow nasal oxygen vs. standard oxygen therapy in immunocompromised patients with acute respiratory failure: study protocol for a randomized controlled trial
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Azoulay, Elie, Lemiale, Virginie, Mokart, Djamel, Nseir, Saad, Argaud, Laurent, Pène, Frédéric, Kontar, Loay, Bruneel, Fabrice, Klouche, Kada, Barbier, François, Reignier, Jean, Stoclin, Anabelle, Louis, Guillaume, Constantin, Jean-Michel, Mayaux, Julien, Wallet, Florent, Kouatchet, Achille, Peigne, Vincent, Perez, Pierre, Girault, Christophe, Jaber, Samir, Oziel, Johanna, Nyunga, Martine, Terzi, Nicolas, Bouadma, Lila, Lebert, Christine, Lautrette, Alexandre, Bigé, Naike, Raphalen, Jean-Herlé, Papazian, Laurent, Rabbat, Antoine, Darmon, Michael, Chevret, Sylvie, and Demoule, Alexandre
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- 2018
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60. Undernourished patients do not have increased risk of severe COVID-19 outcomes
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Fneich, Ahmad, primary, Poinsot, Pierre, additional, Elias, Christelle, additional, Restier, Lioara, additional, Vanhems, Philippe, additional, Wallet, Florent, additional, Caussy, Cyrielle, additional, Duclos, Antoine, additional, and Peretti, Noël, additional
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- 2022
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61. The burden of SARS-CoV-2 in patients receiving chimeric antigen receptor T cell immunotherapy: everything to lose
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Luque-Paz, David, primary, Sesques, Pierre, additional, Wallet, Florent, additional, Bachy, Emmanuel, additional, and Ader, Florence, additional
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- 2022
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62. Final results of the DisCoVeRy trial of remdesivir for patients admitted to hospital with COVID-19
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Ader, Florence, primary, Bouscambert-Duchamp, Maude, additional, Hites, Maya, additional, Peiffer-Smadja, Nathan, additional, Mentré, France, additional, Burdet, Charles, additional, Aboab, Jérôme, additional, Ader, Florence, additional, Ait-Oufella, Hafid, additional, Altdorfer, Antoine, additional, Andrejak, Claire, additional, Andreu, Pascal, additional, Argaud, Laurent, additional, Bani-Sadr, Firouzé, additional, Belhadi, Drifa, additional, Belkhir, Leila, additional, Benezit, François, additional, Berna, Marc, additional, Blot, Mathieu, additional, Botelho-Nevers, Elisabeth, additional, Bouadma, Lila, additional, Bouchaud, Olivier, additional, Bougon, David, additional, Bouiller, Kevin, additional, Bounes-Vardon, Fanny, additional, Boutoille, David, additional, Boyer, Alexandre, additional, Braz, Sandra, additional, Bruel, Cédric, additional, Cabié, André, additional, Canet, Emmanuel, additional, Cazanave, Charles, additional, Chabartier, Cyrille, additional, Chirouze, Catherine, additional, Clere-Jehl, Raphaël, additional, Costagliola, Dominique, additional, Couffin-Cadièrgues, Sandrine, additional, Courjon, Johan, additional, Crockett, Flora, additional, Danion, François, additional, Dechanet, Aline, additional, Delbove, Agathe, additional, Dellamonica, Jean, additional, Delmas, Christelle, additional, Diallo, Alpha, additional, Djossou, Félix, additional, Dubost, Clément, additional, Duvignaud, Alexandre, additional, Egle, Alexander, additional, Epaulard, Olivier, additional, Epelboin, Loïc, additional, Esperou, Hélène, additional, Fartoukh, Murielle, additional, Faure, Karine, additional, Faure, Emmanuel, additional, Ferreira Ribeiro, Joao-Miguel, additional, Ferry, Tristan, additional, Ficko, Cécile, additional, Figueiredo, Samy, additional, Fougerou, Claire, additional, Fraipont, Vincent, additional, Gaborit, Benjamin, additional, Gaci, Rostane, additional, Gagneux-Brunon, Amandine, additional, Gallien, Sébastien, additional, Garot, Denis, additional, Gaymard, Alexandre, additional, Geri, Guillaume, additional, Gibot, Sébastien, additional, Goehringer, François, additional, Gousseff, Marie, additional, Greil, Richard, additional, Gruson, Didier, additional, Guedj, Jérémie, additional, Hansmann, Yves, additional, Hinschberger, Olivier, additional, Jaureguiberry, Stéphane, additional, Jeanmichel, Vanessa, additional, Joannidis, Michael, additional, Kerneis, Solen, additional, Kimmoun, Antoine, additional, Klouche, Kada, additional, Lachâtre, Marie, additional, Lacombe, Karine, additional, Laine, Fabrice, additional, Lamprecht, Bernd, additional, Lanoix, Jean-Philippe, additional, Launay, Odile, additional, Laviolle, Bruno, additional, Lê, Minh-Patrick, additional, Le Moing, Vincent, additional, Le Pavec, Jérôme, additional, Le Tulzo, Yves, additional, Le Turnier, Paul, additional, Lebeaux, David, additional, Lefevre, Benjamin, additional, Leroy, Sylvie, additional, Lescure, François-Xavier, additional, Lessire, Henry, additional, Leveau, Benjamin, additional, Lina, Bruno, additional, Loubet, Paul, additional, Makinson, Alain, additional, Malvy, Denis, additional, Marquette, Charles-Hugo, additional, Martin-Blondel, Guillaume, additional, Martinot, Martin, additional, Mayaux, Julien, additional, Mekontso-Dessap, Armand, additional, Mercier, Noémie, additional, Meziani, Ferhat, additional, Mira, Jean-Paul, additional, Molina, Jean-Michel, additional, Monnet, Xavier, additional, Mootien, Joy, additional, Mourvillier, Bruno, additional, Mourvilliers, Bruno, additional, Murris-Espin, Marlène, additional, Navellou, Jean-Christophe, additional, Noret, Marion, additional, Nseir, Saad, additional, Oulehri, Walid, additional, Paiva, José-Artur, additional, Perpoint, Thomas, additional, Peytavin, Gilles, additional, Pialoux, Gilles, additional, Pilmis, Benoît, additional, Piriou, Vincent, additional, Piroth, Lionel, additional, Poissy, Julien, additional, Pourcher, Valérie, additional, Quenot, Jean-Pierre, additional, Raffi, François, additional, Reignier, Jean, additional, Reuter, Jean, additional, Revest, Matthieu, additional, Richard, Jean-Christophe, additional, Riu-Poulenc, Béatrice, additional, Robert, Céline, additional, Roger, Pierre-Alexandre, additional, Roger, Claire, additional, Roncon-Albuquerque, Roberto, additional, Rouveix-Nordon, Elisabeth, additional, Ruch, Yvon, additional, Saidani, Nadia, additional, Saillard, Juliette, additional, Sayre, Naomi, additional, Senneville, Eric, additional, Sotto, Albert, additional, Staub, Thérèse, additional, Stefan, Francois, additional, Tacquard, Charles, additional, Terzi, Nicolas, additional, Textoris, Julien, additional, Thiery, Guillaume, additional, Timsit, Jean-François, additional, Tolsma, Violaine, additional, Tubiana, Sarah, additional, Turmel, Jean-Marie, additional, Valour, Florent, additional, Vardon-Bounes, Fanny, additional, Velou, Priyanka, additional, Verschelden, Gil, additional, Wallet, Florent, additional, Wattecamps, Guilhem, additional, Yazdanpanah, Yazdan, additional, and Zerbib, Yoann, additional
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- 2022
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63. Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trial
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Lingas, Guillaume, Néant, Nadège, Gaymard, Alexandre, Belhadi, Drifa, Peytavin, Gilles, Hites, Maya, Staub, Thérèse, Greil, Richard, Paiva, Josél Artur, Poissy, Julien, Peiffer-Smadja, Nathan, Costagliola, Dominique, Yazdanpanah, Yazdan, Wallet, Florent, Gagneux-Brunon, Amandine, Mentré, France, Ader, Florence, Burdet, Charles, Guedj, Jeremie, Bouscambert-Duchamp, Maude, Lingas, Guillaume, Néant, Nadège, Gaymard, Alexandre, Belhadi, Drifa, Peytavin, Gilles, Hites, Maya, Staub, Thérèse, Greil, Richard, Paiva, Josél Artur, Poissy, Julien, Peiffer-Smadja, Nathan, Costagliola, Dominique, Yazdanpanah, Yazdan, Wallet, Florent, Gagneux-Brunon, Amandine, Mentré, France, Ader, Florence, Burdet, Charles, Guedj, Jeremie, and Bouscambert-Duchamp, Maude
- Abstract
Background: The antiviral efficacy of remdesivir in COVID-19 hospitalized patients remains controversial. Objectives: To estimate the effect of remdesivir in blocking viral replication. Methods: We analysed nasopharyngeal normalized viral loads from 665 hospitalized patients included in the DisCoVeRy trial (NCT 04315948; EudraCT 2020-000936-23), randomized to either standard of care (SoC) or SoC + remdesivir. We used a mathematical model to reconstruct viral kinetic profiles and estimate the antiviral efficacy of remdesivir in blocking viral replication. Additional analyses were conducted stratified on time of treatment initiation (≤7 or >7 days since symptom onset) or viral load at randomization (< or ≥3.5 log10 copies/104 cells). Results: In our model, remdesivir reduced viral production by infected cells by 2-fold on average (95% CI: 1.5-3.2-fold). Model-based simulations predict that remdesivir reduced time to viral clearance by 0.7 days compared with SoC, with large inter-individual variabilities (IQR: 0.0-1.3 days). Remdesivir had a larger impact in patients with high viral load at randomization, reducing viral production by 5-fold on average (95% CI: 2.8-25-fold) and the median time to viral clearance by 2.4 days (IQR: 0.9-4.5 days). Conclusions: Remdesivir halved viral production, leading to a median reduction of 0.7 days in the time to viral clearance compared with SoC. The efficacy was larger in patients with high viral load at randomization., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2022
64. Relevance of blood cultures in acute pyelonephritis in a single-center retrospective study
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Ledochowski, Stanislas, Abraham, Paul-Samuel, Jacob, Xavier, Dumitrescu, Oana, Lina, Gérard, Lepape, Alain, Piriou, Vincent, Wallet, Florent, and Friggeri, Arnaud
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- 2015
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65. Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases
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Leone, Marc, Bechis, Carole, Baumstarck, Karine, Ouattara, Alexandre, Collange, Olivier, Augustin, Pascal, Annane, Djillali, Arbelot, Charlotte, Asehnoune, Karim, Baldési, Olivier, Bourcier, Simon, Delapierre, Laurence, Demory, Didier, Hengy, Baptiste, Ichai, Carole, Kipnis, Eric, Brasdefer, Etienne, Lasocki, Sigismond, Legrand, Matthieu, Mimoz, Olivier, Rimmelé, Thomas, Aliane, Jugurtha, Bertrand, Pierre-Marie, Bruder, Nicolas, Klasen, Fanny, Friou, Emilie, Lévy, Bruno, Martinez, Oriane, Peytel, Eric, Piton, Alexandra, Richter, Elisa, Toufik, Kamel, Vogler, Marie-Charlotte, Wallet, Florent, Boufi, Mourad, Allaouchiche, Bernard, Constantin, Jean-Michel, Martin, Claude, Jaber, Samir, and Lefrant, Jean-Yves
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- 2015
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66. Internal necklace as a nasogastric tube placement complication
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ZOGHBI, Soufia, primary, VACHERON, Charles-Hervé, additional, VASSAL, Olivia, additional, WALLET, Florent, additional, and ALLAOUCHICHE, Bernard, additional
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- 2022
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67. Remdesivir for the treatment of hospitalised patients with COVID-19: final results from the DisCoVeRy randomised, controlled, open-label trial
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Ader, Florence, primary, Bouscambert-Duchamp, Maude, additional, Hites, Maya, additional, Peiffer-Smadja, Nathan, additional, Poissy, Julien, additional, Belhadi, Drifa, additional, Diallo, Alpha, additional, Delmas, Christelle, additional, Saillard, Juliette, additional, Dechanet, Aline, additional, Fougerou, Claire, additional, Lê, Minh-Patrick, additional, Peytavin, Gilles, additional, Mercier, Noémie, additional, Velou, Priyanka, additional, Tubiana, Sarah, additional, Lescure, Xavier, additional, Faure, Emmanuel, additional, Nseir, Saad, additional, Richard, Jean-Christophe, additional, Wallet, Florent, additional, Goehringer, François, additional, Lefèvre, Benjamin, additional, Kimmoun, Antoine, additional, Raffi, François, additional, Gaborit, Benjamin, additional, Reignier, Jean, additional, Lanoix, Jean-Philippe, additional, Andrejak, Claire, additional, Zerbib, Yoann, additional, Bani-Sadr, Firouzé, additional, Mourvilliers, Bruno, additional, Danion, François, additional, Ruch, Yvon, additional, Clere-Jehl, Raphaël, additional, Le Moing, Vincent, additional, Klouche, Kada, additional, Lacombe, Karine, additional, Martin-Blondel, Guillaume, additional, Vardon-Bounes, Fanny, additional, Cabié, André, additional, Turmel, Jean-Marie, additional, Piroth, Lionel, additional, Blot, Mathieu, additional, Botelho-Nevers, Élisabeth, additional, Gagneux-Brunon, Amandine, additional, Thiery, Guillaume, additional, Bénézit, François, additional, Gaci, Rostane, additional, Mootien, Joy, additional, Gallien, Sébastien, additional, Garot, Denis, additional, Bouiller, Kevin, additional, Epelboin, Loïc, additional, Jauréguiberry, Stéphane, additional, Gaymard, Alexandre, additional, Verschelden, Gil, additional, Braz, Sandra, additional, Ferreira Ribeiro, Joao Miguel, additional, Joannidis, Michael, additional, Staub, Thérèse, additional, Altdorfer, Antoine, additional, Greil, Richard, additional, Egle, Alexander, additional, Guedj, Jérémie, additional, Noret, Marion, additional, Roncon-Albuquerque, Roberto, additional, Paiva, Jose-Artur, additional, Lina, Bruno, additional, Costagliola, Dominique, additional, Yazdanpanah, Yazdan, additional, Burdet, Charles, additional, and Mentré, France, additional
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- 2022
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68. Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trial
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Lingas, Guillaume, primary, Néant, Nadège, additional, Gaymard, Alexandre, additional, Belhadi, Drifa, additional, Peytavin, Gilles, additional, Hites, Maya, additional, Staub, Thérèse, additional, Greil, Richard, additional, Paiva, Jose-Artur, additional, Poissy, Julien, additional, Peiffer-Smadja, Nathan, additional, Costagliola, Dominique, additional, Yazdanpanah, Yazdan, additional, Wallet, Florent, additional, Gagneux-Brunon, Amandine, additional, Mentré, France, additional, Ader, Florence, additional, Burdet, Charles, additional, Guedj, Jérémie, additional, and Bouscambert-Duchamp, Maude, additional
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- 2022
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69. Additional file 1 of Impact of prolonged requirement for insulin on 90-day mortality in critically ill patients without previous diabetic treatments: a post hoc analysis of the CONTROLING randomized control trial
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Thouy, François, Bohé, Julien, Souweine, Bertrand, Abidi, Hassane, Quenot, Jean-Pierre, Thiollière, Fabrice, Dellamonica, Jean, Preiser, Jean-Charles, Timsit, Jean-François, Brunot, Vincent, Klich, Amna, Sedillot, Nicholas, Tchenio, Xavier, Roudaut, Jean-Baptiste, Mottard, Nicolas, Hyvernat, Hervé, Wallet, Florent, Danin, Pierre-Eric, Badie, Julio, Jospe, Richard, Morel, Jérôme, Mofredj, Ali, Fatah, Abdelhamid, Drai, Jocelyne, Mialon, Anne, Ait Hssain, Ali, Lautrette, Alexandre, Fontaine, Eric, Vacheron, Charles-Hervé, Maucort-Boulch, Delphine, Klouche, Kada, and Dupuis, Claire
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Additional file 1. Table S1: Glycemic targets according to HbA1c level and distribution of patients according to HbA1c. Table S2: Characteristics of the patients included at Day 5 depending on PRI and glycemic control status. Table S3: Propensity score: having PRI on day 5. Multivariate logistic regression model. Figure S1: Histogram of the distribution of the propensity score (having Prolonged requirement of insulin at day 5). Table S4: Main results with weight truncation as sensitivity analyses – impact of PRI on the occurrence of death before day 90 among, a cox survival model with ponderation on IPTW. Table S5: Sensitivity analyses: multivariate Cox hazard model without weighting for IPTW: association between PRI and the occurrence of death before day 90. Table S6: Subgroup analysis of patients with an HbA1C
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- 2022
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70. Noninvasive ventilation vs. high-flow nasal cannula oxygen for preoxygenation before intubation in patients with obesity: a post hoc analysis of a randomized controlled trial
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Rodriguez, Maeva, Ragot, Stéphanie, Coudroy, Rémi, Quenot, Jean-Pierre, Vignon, Philippe, Forel, Jean-Marie, Demoule, Alexandre, Mira, Jean-Paul, Ricard, Jean-Damien, Nseir, Saad, Colin, Gwenhael, Pons, Bertrand, Danin, Pierre-Eric, Devaquet, Jérome, Prat, Gwenael, Merdji, Hamid, Petitpas, Franck, Vivier, Emmanuel, Mekontso-Dessap, Armand, Nay, Mai-Anh, Asfar, Pierre, Dellamonica, Jean, Argaud, Laurent, Ehrmann, Stephan, Fartoukh, Muriel, Girault, Christophe, Robert, René, Thille, Arnaud, Frat, Jean-Pierre, Chatellier, Delphine, Boissier, Florence, Veinstein, Anne, Dahyot-Fizelier, Claire, Dargent, Auguste, Large, Audrey, Begot, Emmanuelle, Mancia, Claire, Decavele, Maxence, Dres, Martin, Lehingue, Samuel, Papazian, Laurent, Paul, Marine, Marin, Nathalie, Le Meur, Matthieu, Laissy, Mohammed, Rouzé, Anahita, Henry-Lagarrigue, Matthieu, Yehia, Aihem, Martino, Frédéric, Cerf, Charles, Bailly, Pierre, Helms, Julie, Putegnat, Jean Baptiste, Razazi, Keyvan, Boulain, Thierry, Cabasson, Séverin, Wallet, Florent, Klouche, Kada, Bellec, Frédéric, Service de Médecine Intensive Réanimation [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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medicine.medical_treatment ,Respiratory failure ,Critical Care and Intensive Care Medicine ,medicine.disease_cause ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Hypoxemia ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,High-flow oxygen ,law ,Preoxygenation ,Post-hoc analysis ,medicine ,Intubation ,030212 general & internal medicine ,Obesity ,Respiratory system ,2. Zero hunger ,business.industry ,RC86-88.9 ,Research ,Medical emergencies. Critical care. Intensive care. First aid ,3. Good health ,Intubation procedure ,030228 respiratory system ,Anesthesia ,Non-invasive ventilation ,medicine.symptom ,business ,Nasal cannula - Abstract
Background Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as compared with high-flow nasal cannula oxygen may decrease the risk of severe hypoxemia in patients with obesity. Methods Post hoc subgroup analysis of critically ill patients with obesity (body mass index ≥ 30 kg·m−2) from a multicenter randomized controlled trial comparing preoxygenation with noninvasive ventilation and high-flow nasal oxygen before intubation of patients with acute hypoxemic respiratory failure (PaO2/FiO2 Results Among the 313 patients included in the original trial, 91 (29%) had obesity with a mean body mass index of 35 ± 5 kg·m−2. Patients with obesity were more likely to experience an episode of severe hypoxemia during intubation procedure than patients without obesity: 34% (31/91) vs. 22% (49/222); difference, 12%; 95% CI 1 to 23%; P = 0.03. Among patients with obesity, 40 received preoxygenation with noninvasive ventilation and 51 with high-flow nasal oxygen. Severe hypoxemia occurred in 15 patients (37%) with noninvasive ventilation and 16 patients (31%) with high-flow nasal oxygen (difference, 6%; 95% CI − 13 to 25%; P = 0.54). The lowest pulse oximetry values during intubation procedure were 87% [interquartile range, 77–93] with noninvasive ventilation and 86% [78–92] with high-flow nasal oxygen (P = 0.98). After multivariable analysis, factors independently associated with severe hypoxemia in patients with obesity were intubation difficulty scale > 5 points and respiratory primary failure as reason for admission. Conclusions Patients with obesity and acute hypoxemic respiratory failure had an increased risk of severe hypoxemia during intubation procedure as compared to patients without obesity. However, preoxygenation with noninvasive ventilation may not reduce this risk compared with high-flow nasal oxygen. Trial registration Clinical trial number: NCT02668458 (http://www.clinicaltrials.gov)
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- 2021
71. An open-label randomized, controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19 – Final results from the DisCoVeRy trial
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Ader, Florence, primary, Peiffer-Smadja, Nathan, additional, Poissy, Julien, additional, Bouscambert-Duchamp, Maude, additional, Belhadi, Drifa, additional, Diallo, Alpha, additional, Delmas, Christelle, additional, Saillard, Juliette, additional, Dechanet, Aline, additional, Mercier, Noémie, additional, Dupont, Axelle, additional, Alfaiate, Toni, additional, Lescure, François-Xavier, additional, Raffi, François, additional, Goehringer, François, additional, Kimmoun, Antoine, additional, Jaureguiberry, Stéphane, additional, Reignier, Jean, additional, Nseir, Saad, additional, Danion, François, additional, Clere-Jehl, Raphael, additional, Bouiller, Kévin, additional, Navellou, Jean-Christophe, additional, Tolsma, Violaine, additional, Cabie, André, additional, Dubost, Clément, additional, Courjon, Johan, additional, Leroy, Sylvie, additional, Mootien, Joy, additional, Gaci, Rostane, additional, Mourvillier, Bruno, additional, Faure, Emmanuel, additional, Pourcher, Valérie, additional, Gallien, Sébastien, additional, Launay, Odile, additional, Lacombe, Karine, additional, Lanoix, Jean-Philippe, additional, Makinson, Alain, additional, Martin-Blondel, Guillaume, additional, Bouadma, Lila, additional, Botelho-Nevers, Elisabeth, additional, Gagneux-Brunon, Amandine, additional, Epaulard, Olivier, additional, Piroth, Lionel, additional, Wallet, Florent, additional, Richard, Jean-Christophe, additional, Reuter, Jean, additional, Staub, Thérèse, additional, Lina, Bruno, additional, Noret, Marion, additional, Andrejak, Claire, additional, Lê, Minh Patrick, additional, Peytavin, Gilles, additional, Hites, Maya, additional, Costagliola, Dominique, additional, Yazdanpanah, Yazdan, additional, Burdet, Charles, additional, and Mentre, France, additional
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- 2022
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72. Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial
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Ader, Florence, primary, Bouscambert-Duchamp, Maude, additional, Hites, Maya, additional, Peiffer-Smadja, Nathan, additional, Poissy, Julien, additional, Belhadi, Drifa, additional, Diallo, Alpha, additional, Lê, Minh-Patrick, additional, Peytavin, Gilles, additional, Staub, Thérèse, additional, Greil, Richard, additional, Guedj, Jérémie, additional, Paiva, Jose-Artur, additional, Costagliola, Dominique, additional, Yazdanpanah, Yazdan, additional, Burdet, Charles, additional, Mentré, France, additional, Egle, Alexander, additional, Joannidis, Michael, additional, Lamprecht, Bernd, additional, Altdorfer, Antoine, additional, Belkhir, Leila, additional, Fraipont, Vincent, additional, Verschelden, Gil, additional, Aboab, Jérôme, additional, Ader, Florence, additional, Ait-Oufella, Hafid, additional, Andrejak, Claire, additional, Andreu, Pascal, additional, Argaud, Laurent, additional, Bani-Sadr, Firouzé, additional, Benezit, François, additional, Blot, Mathieu, additional, Botelho-Nevers, Elisabeth, additional, Bouadma, Lila, additional, Bouchaud, Olivier, additional, Bougon, David, additional, Bouiller, Kevin, additional, Bounes-Vardon, Fanny, additional, Boutoille, David, additional, Boyer, Alexandre, additional, Bruel, Cédric, additional, Cabié, André, additional, Canet, Emmanuel, additional, Cazanave, Charles, additional, Chabartier, Cyrille, additional, Chirouze, Catherine, additional, Clere-Jehl, Raphaël, additional, Courjon, Johan, additional, Crockett, Flora, additional, Danion, François, additional, Delbove, Agathe, additional, Dellamonica, Jean, additional, Djossou, Félix, additional, Dubost, Clément, additional, Duvignaud, Alexandre, additional, Epaulard, Olivier, additional, Epelboin, Loïc, additional, Fartoukh, Murielle, additional, Faure, Karine, additional, Faure, Emmanuel, additional, Ferry, Tristan, additional, Ficko, Cécile, additional, Figueiredo, Samy, additional, Gaborit, Benjamin, additional, Gaci, Rostane, additional, Gagneux-Brunon, Amandine, additional, Gallien, Sébastien, additional, Garot, Denis, additional, Geri, Guillaume, additional, Gibot, Sébastien, additional, Goehringer, François, additional, Gousseff, Marie, additional, Gruson, Didier, additional, Hansmann, Yves, additional, Hinschberger, Olivier, additional, Jaureguiberry, Stéphane, additional, Jeanmichel, Vanessa, additional, Kerneis, Solen, additional, Kimmoun, Antoine, additional, Klouche, Kada, additional, Lachâtre, Marie, additional, Lacombe, Karine, additional, Laine, Fabrice, additional, Lanoix, Jean-Philippe, additional, Launay, Odile, additional, Laviolle, Bruno, additional, Le Moing, Vincent, additional, Le Pavec, Jérôme, additional, Le Tulzo, Yves, additional, Le Turnier, Paul, additional, Lebeaux, David, additional, Lefevre, Benjamin, additional, Leroy, Sylvie, additional, Lescure, François-Xavier, additional, Lessire, Henry, additional, Leveau, Benjamin, additional, Loubet, Paul, additional, Makinson, Alain, additional, Malvy, Denis, additional, Marquette, Charles-Hugo, additional, Martin-Blondel, Guillaume, additional, Martinot, Martin, additional, Mayaux, Julien, additional, Mekontso-Dessap, Armand, additional, Meziani, Ferhat, additional, Mira, Jean-Paul, additional, Molina, Jean-Michel, additional, Monnet, Xavier, additional, Mootien, Joy, additional, Mourvillier, Bruno, additional, Murris-Espin, Marlène, additional, Navellou, Jean-Christophe, additional, Nseir, Saad, additional, Oulehri, Walid, additional, Perpoint, Thomas, additional, Pialoux, Gilles, additional, Pilmis, Benoît, additional, Piriou, Vincent, additional, Piroth, Lionel, additional, Pourcher, Valérie, additional, Quenot, Jean-Pierre, additional, Raffi, François, additional, Reignier, Jean, additional, Revest, Matthieu, additional, Richard, Jean-Christophe, additional, Riu-Poulenc, Béatrice, additional, Robert, Céline, additional, Roger, Pierre-Alexandre, additional, Roger, Claire, additional, Rouveix-Nordon, Elisabeth, additional, Ruch, Yvon, additional, Saidani, Nadia, additional, Sayre, Naomi, additional, Senneville, Eric, additional, Sotto, Albert, additional, Stefan, Francois, additional, Tacquard, Charles, additional, Terzi, Nicolas, additional, Textoris, Julien, additional, Thiery, Guillaume, additional, Timsit, Jean-François, additional, Tolsma, Violaine, additional, Turmel, Jean-Marie, additional, Valour, Florent, additional, Wallet, Florent, additional, Wattecamps, Guilhem, additional, Zerbib, Yoann, additional, Berna, Marc, additional, Reuter, Jean, additional, Braz, Sandra, additional, Ferreira Ribeiro, Joao-Miguel, additional, Paiva, José-Artur, additional, Roncon-Albuquerque, Roberto, additional, Gaymard, Alexandre, additional, Lina, Bruno, additional, Tubiana, Sarah, additional, Couffin-Cadièrgues, Sandrine, additional, Esperou, Hélène, additional, Dechanet, Aline, additional, Delmas, Christelle, additional, Fougerou, Claire, additional, Mercier, Noémie, additional, Noret, Marion, additional, Saillard, Juliette, additional, and Velou, Priyanka, additional
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- 2022
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73. Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study-a randomized clinical trial
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Bohé, Julien, Abidi, Hassane, Brunot, Vincent, Klich, Amna, Klouche, Kada, Sedillot, Nicholas, Tchenio, Xavier, Quenot, Jean-Pierre, Roudaut, Jean-Baptiste, Mottard, Nicolas, Thiollière, Fabrice, Dellamonica, Jean, Wallet, Florent, Souweine, Bertrand, Lautrette, Alexandre, Preiser, Jean-Charles, Timsit, Jean-François, Vacheron, Charles-Hervé, Ait Hssain, Ali, Maucort-Boulch, Delphine, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Fleyriat [Bourg en Bresse], CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer (LabEx LipSTIC), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Université de Montpellier (UM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Fondation de Coopération Scientifique Bourgogne Franche-Comté (FCS Bourgogne Franche-Comté), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital l'Archet, Unité de Recherche Clinique de la Côte d’Azur [Nice] (URRIS UR2CA), Université Côte d'Azur (UCA), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Laboratoire Microorganismes : Génome et Environnement (LMGE), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université libre de Bruxelles (ULB), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), CONTROLe INdividualisé de la Glycémie (CONTROLING) Study Group: Aurèle Buzancais, Anne Marie Dupuy, Rémi Bruyère, Henri de Montclos, Marion Provent, Jocelyne Drai, Joëlle Goudable, Anne Mialon, Bernard Allaouchiche, Arnaud Friggeri, Véréna Landel, Hélène Boyer, Hervé Hyvernat, Céline Caruba-Bafghi, Edouard Soum, Christophe Leroy, Laurence Roszyk, Pierre Eric Danin, Julio Badie, Stefan Georgiev, Martine Laplace, Richard Jospe, Jérôme Morel, Ali Mofredj, Abdelbaki Azaouzi, Jean-Paul Aubry, Abdelhamid Fatah, Stanislas Ledochowski, Sabine Zaepfel, Eric Fontaine, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, École Pratique des Hautes Études (EPHE), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Université de Montpellier (UM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Unité de Recherche Clinique de la Côte d’Azur (URRIS UR2CA), Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Service de Biostatistiques [Lyon], and MORNET, Dominique
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[SDV] Life Sciences [q-bio] ,Glycated haemoglobin A1c ,[SDV]Life Sciences [q-bio] ,Glucose control ,Individualised glucose control ,Hyperglycaemia ,Insulin - Abstract
International audience; Purpose: Hyperglycaemia is an adaptive response to stress commonly observed in critical illness. Its management remains debated in the intensive care unit (ICU). Individualising hyperglycaemia management, by targeting the patient's pre-admission usual glycaemia, could improve outcome.Methods: In a multicentre, randomized, double-blind, parallel-group study, critically-ill adults were considered for inclusion. Patients underwent until ICU discharge either individualised glucose control by targeting the pre-admission usual glycaemia using the glycated haemoglobin A1c level at ICU admission (IC group), or conventional glucose control by maintaining glycaemia below 180 mg/dL (CC group). A non-commercial web application of a dynamic sliding-scale insulin protocol gave to nurses all instructions for glucose control in both groups. The primary outcome was death within 90 days.Results: Owing to a low likelihood of benefit and evidence of the possibility of harm related to hypoglycaemia, the study was stopped early. 2075 patients were randomized; 1917 received the intervention, 942 in the IC group and 975 in the CC group. Although both groups showed significant differences in terms of glycaemic control, survival probability at 90-day was not significantly different (IC group: 67.2%, 95% CI [64.2%; 70.3%]; CC group: 69.6%, 95% CI [66.7%; 72.5%]). Severe hypoglycaemia (below 40 mg/dL) occurred in 3.9% of patients in the IC group and in 2.5% of patients in the CC group (p = 0.09). A post hoc analysis showed for non-diabetic patients a higher risk of 90-day mortality in the IC group compared to the CC group (HR 1.3, 95% CI [1.05; 1.59], p = 0.018).Conclusion: Targeting an ICU patient's pre-admission usual glycaemia using a dynamic sliding-scale insulin protocol did not demonstrate a survival benefit compared to maintaining glycaemia below 180 mg/dL.
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- 2021
74. Neuromuscular monitoring and neuromuscular blocking agent shortages when treating critically ill COVID-19 patients: a multicentre retrospective analysis
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Ziatkowski-Michaud, Julia, Mazard, Tessa, Delignette, Marie-Charlotte, Wallet, Florent, Aubrun, Frederic, and Dziadzko, Mikhail
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- 2021
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75. Erratum to: Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases
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Leone, Marc, Bechis, Carole, Baumstarck, Karine, Ouattara, Alexandre, Collange, Olivier, Augustin, Pascal, Annane, Djillali, Arbelot, Charlotte, Asehnoune, Karim, Baldési, Olivier, Bourcier, Simon, Delapierre, Laurence, Demory, Didier, Hengy, Baptiste, Ichai, Carole, Kipnis, Eric, Brasdefer, Etienne, Lasocki, Sigismond, Legrand, Matthieu, Mimoz, Olivier, Rimmelé, Thomas, Aliane, Jugurtha, Bertrand, Pierre-Marie, Bruder, Nicolas, Klasen, Fanny, Friou, Emilie, Lévy, Bruno, Martinez, Oriane, Peytel, Eric, Piton, Alexandra, Richter, Elisa, Kamel, Toufik, Vogler, Marie-Charlotte, Wallet, Florent, Boufi, Mourad, Allaouchiche, Bernard, Constantin, Jean-Michel, Martin, Claude, Jaber, Samir, and Lefrant, Jean-Yves
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- 2015
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76. Population Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient
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Garreau, Romain, primary, Falquet, Benoît, additional, Mioux, Lisa, additional, Bourguignon, Laurent, additional, Ferry, Tristan, additional, Tod, Michel, additional, Wallet, Florent, additional, Friggeri, Arnaud, additional, Richard, Jean-Christophe, additional, and Goutelle, Sylvain, additional
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- 2021
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77. Putative invasive pulmonary aspergillosis in critically ill patients with chronic obstructive pulmonary disease: a matched cohort study
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Delsuc, Claire, Cottereau, Aurélie, Frealle, Emilie, Bienvenu, Anne-Lise, Dessein, Rodrigue, Jarraud, Sophie, Dumitrescu, Oana, Le Maréchal, Marion, Wallet, Florent, Friggeri, Arnaud, Argaud, Laurent, Rimmelé, Thomas, Nseir, Saad, and Ader, Florence
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- 2015
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78. Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial
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Richard, Jean-Christophe, Bayle, Frédérique, Bourdin, Gael, Leray, Véronique, Debord, Sophie, Delannoy, Bertrand, Stoian, Alina Cividjian, Wallet, Florent, Yonis, Hodane, and Guerin, Claude
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- 2015
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79. Replicating finding, answering questions: closer to the truth about COVID-19 associated VAP.
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Vacheron, Charles-Hervé, Fort, Romain, Dagonneau, Tristan, Friggeri, Arnaud, Wallet, Florent, HospiceRea Study Group, Bohe, Julien, Richard, Jean-christophe, Rimmele, Thomas, Lukaszewicz, Anne-Claire, Dailler, Frederic, Aubrun, Frederic, Fellahi, Jean-Luc, Allaouchiche, Bernard, Hodille, Elisabeth, Levrard, Melanie, Gerbaud-Coula, Chloé, Joffredo, Emilie, Thiolliere, Fabrice, and Vassal, Olivia
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- 2023
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80. A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients.
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Tardiveau, Claire, Monneret, Guillaume, Lukaszewicz, Anne-Claire, Cheynet, Valérie, Cerrato, Elisabeth, Imhoff, Katia, Peronnet, Estelle, Bodinier, Maxime, Kreitmann, Louis, Blein, Sophie, Llitjos, Jean-François, Conti, Filippo, Gossez, Morgane, Buisson, Marielle, Yonis, Hodane, Cour, Martin, Argaud, Laurent, Delignette, Marie-Charlotte, Wallet, Florent, and Dailler, Frederic
- Subjects
COVID-19 ,CRITICALLY ill ,HOSPITAL admission & discharge ,MORTALITY ,PROTOTYPES - Abstract
Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex transcriptomic panel prototype termed Immune Profiling Panel (IPP) could capture the dysregulation of immune responses of ICU COVID-19 patients at admission. Nine transcripts were associated with mortality in univariate analysis and this 9-mRNA signature remained significantly associated with mortality in a multivariate analysis that included age, SOFA and Charlson scores. Using a machine learning model with these 9 mRNA, we could predict the 28-day survival status with an Area Under the Receiver Operating Curve (AUROC) of 0.764. Interestingly, adding patients' age to the model resulted in increased performance to predict the 28-day mortality (AUROC reaching 0.839). This prototype IPP demonstrated that such a tool, upon clinical/analytical validation and clearance by regulatory agencies could be used in clinical routine settings to quickly identify patients with higher risk of death requiring thus early aggressive intensive care. [ABSTRACT FROM AUTHOR]
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- 2022
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81. BMI and pneumonia outcomes in critically ill COVID‐19 patients: An international multicenter study
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Chetboun, Mikael, primary, Raverdy, Violeta, additional, Labreuche, Julien, additional, Simonnet, Arthur, additional, Wallet, Florent, additional, Caussy, Cyrielle, additional, Antonelli, Massimo, additional, Artigas, Antonio, additional, Goma, Gemma, additional, Meziani, Ferhat, additional, Helms, Julie, additional, Mylonakis, Eleftherios, additional, Levy, Mitchell M., additional, Kalligeros, Markos, additional, Latronico, Nicola, additional, Piva, Simone, additional, Cerf, Charles, additional, Neuville, Mathilde, additional, Klouche, Kada, additional, Larcher, Romaric, additional, Tamion, Fabienne, additional, Occhiali, Emilie, additional, Snacken, Morgane, additional, Preiser, Jean‐Charles, additional, Kontar, Loay, additional, Riviere, Antoine, additional, Silva, Stein, additional, Sarton, Benjamine, additional, Krouchi, Raphael, additional, Dubar, Victoria, additional, Palaiodimos, Leonidas, additional, Karamanis, Dimitrios, additional, Perche, Juliette, additional, L'Her, Erwan, additional, Busetto, Luca, additional, Dicker, Dror, additional, Lev, Shaul, additional, Duhamel, Alain, additional, Jourdain, Mercè, additional, and Pattou, François, additional
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- 2021
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82. Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study
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Goutelle, Sylvain, primary, Jay, Lucille, additional, Boidin, Clément, additional, Cohen, Sabine, additional, Bourguignon, Laurent, additional, Bleyzac, Nathalie, additional, Wallet, Florent, additional, Vassal, Olivia, additional, and Friggeri, Arnaud, additional
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- 2021
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83. Correlation between Skin temperature gradient assessed by infrared thermography and severity in intensive care patients: a pilot exploratory study
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VACHERON, Charles-Hervé, primary, MAGNIN, Mathieu, additional, MEKHATRIA, Amina, additional, THIOLLIÈRE, Fabrice, additional, FRIGGERI, Arnaud, additional, WALLET, Florent, additional, and ALLAOUCHICHE, Bernard, additional
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- 2021
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84. Prognostic Impact of 18F-FDG PET/CT in Patients With Aggressive B-Cell Lymphoma Treated With Anti-CD19 Chimeric Antigen Receptor T Cells
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Sesques, Pierre, primary, Tordo, Jérémie, additional, Ferrant, Emmanuelle, additional, Safar, Violaine, additional, Wallet, Florent, additional, Dhomps, Anthony, additional, Brisou, Gabriel, additional, Bouafia, Fadhela, additional, Karlin, Lionel, additional, Ghergus, Dana, additional, Golfier, Camille, additional, Lequeu, Helène, additional, Lazareth, Anne, additional, Vercasson, Marlène, additional, Hospital-Gustem, Carole, additional, Schwiertz, Vérane, additional, Choquet, Marion, additional, Sujobert, Pierre, additional, Novelli, Silvana, additional, Mialou, Valérie, additional, Hequet, Olivier, additional, Carras, Sylvain, additional, Fouillet, Ludovic, additional, Lebras, Laure, additional, Guillermin, Yann, additional, Leyronnas, Cécile, additional, Cavalieri, Doriane, additional, Janier, Marc, additional, Ghesquières, Hervé, additional, Salles, Gilles, additional, and Bachy, Emmanuel, additional
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- 2021
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85. Additional file 4 of Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial
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Richard, Jean-Christophe, Yonis, Hodane, Bitker, Laurent, Roche, Sylvain, Wallet, Florent, Dupuis, Claire, Serrier, Hassan, Argaud, Laurent, Thiery, Guillaume, Delannoy, Bertrand, Pommier, Christian, Abraham, Paul, Muller, Michel, Aubrun, Frederic, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Terzi, Nicolas, and Rabilloud, Muriel
- Abstract
Additional file 4. Study sites.
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- 2021
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86. Additional file 13 of Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial
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Richard, Jean-Christophe, Yonis, Hodane, Bitker, Laurent, Roche, Sylvain, Wallet, Florent, Dupuis, Claire, Serrier, Hassan, Argaud, Laurent, Thiery, Guillaume, Delannoy, Bertrand, Pommier, Christian, Abraham, Paul, Muller, Michel, Aubrun, Frederic, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Terzi, Nicolas, and Rabilloud, Muriel
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Additional file 13. Ethical approval document (English).
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- 2021
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87. Additional file 6 of Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial
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Richard, Jean-Christophe, Bayle, Frédérique, Bourdin, Gael, Leray, Véronique, Debord, Sophie, Delannoy, Bertrand, Stoian, Alina Cividjian, Wallet, Florent, Yonis, Hodane, and Guerin, Claude
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nervous system ,musculoskeletal, neural, and ocular physiology ,macromolecular substances - Abstract
Severe sepsis randomized controlled trials published since 2010.
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- 2021
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88. Additional file 5 of Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial
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Richard, Jean-Christophe, Bayle, Frédérique, Bourdin, Gael, Leray, Véronique, Debord, Sophie, Delannoy, Bertrand, Stoian, Alina Cividjian, Wallet, Florent, Yonis, Hodane, and Guerin, Claude
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Protocol violations regarding intravascular volume expansion.
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- 2021
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89. Additional file 3 of Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial
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Richard, Jean-Christophe, Yonis, Hodane, Bitker, Laurent, Roche, Sylvain, Wallet, Florent, Dupuis, Claire, Serrier, Hassan, Argaud, Laurent, Thiery, Guillaume, Delannoy, Bertrand, Pommier, Christian, Abraham, Paul, Muller, Michel, Aubrun, Frederic, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Terzi, Nicolas, and Rabilloud, Muriel
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Additional file 3. WHO Trial Registration Dataset.
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- 2021
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90. Additional file 2 of Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial
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Richard, Jean-Christophe, Bayle, Frédérique, Bourdin, Gael, Leray, Véronique, Debord, Sophie, Delannoy, Bertrand, Stoian, Alina Cividjian, Wallet, Florent, Yonis, Hodane, and Guerin, Claude
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Evolution of hemoglobin levels over time.
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- 2021
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91. Additional file 8 of Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial
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Richard, Jean-Christophe, Yonis, Hodane, Bitker, Laurent, Roche, Sylvain, Wallet, Florent, Dupuis, Claire, Serrier, Hassan, Argaud, Laurent, Thiery, Guillaume, Delannoy, Bertrand, Pommier, Christian, Abraham, Paul, Muller, Michel, Aubrun, Frederic, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Terzi, Nicolas, and Rabilloud, Muriel
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Additional file 8. IES-R questionnaire (French version).
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- 2021
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92. Additional file 7 of Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial
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Richard, Jean-Christophe, Yonis, Hodane, Bitker, Laurent, Roche, Sylvain, Wallet, Florent, Dupuis, Claire, Serrier, Hassan, Argaud, Laurent, Thiery, Guillaume, Delannoy, Bertrand, Pommier, Christian, Abraham, Paul, Muller, Michel, Aubrun, Frederic, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Terzi, Nicolas, and Rabilloud, Muriel
- Abstract
Additional file 7. TMoCA questionnaire (French version).
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- 2021
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93. Additional file 2 of Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial
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Richard, Jean-Christophe, Yonis, Hodane, Bitker, Laurent, Roche, Sylvain, Wallet, Florent, Dupuis, Claire, Serrier, Hassan, Argaud, Laurent, Thiery, Guillaume, Delannoy, Bertrand, Pommier, Christian, Abraham, Paul, Muller, Michel, Aubrun, Frederic, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Terzi, Nicolas, and Rabilloud, Muriel
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Data_FILES - Abstract
Additional file 2. Study protocol version 4.
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- 2021
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94. Additional file 1 of Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial
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Richard, Jean-Christophe, Bayle, Frédérique, Bourdin, Gael, Leray, Véronique, Debord, Sophie, Delannoy, Bertrand, Stoian, Alina Cividjian, Wallet, Florent, Yonis, Hodane, and Guerin, Claude
- Abstract
Fluid administration.
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- 2021
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95. Additional file 4 of Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial
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Richard, Jean-Christophe, Bayle, Frédérique, Bourdin, Gael, Leray, Véronique, Debord, Sophie, Delannoy, Bertrand, Stoian, Alina Cividjian, Wallet, Florent, Yonis, Hodane, and Guerin, Claude
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Causes of death and limitation of treatment.
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- 2021
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96. Additional file 3 of Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial
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Richard, Jean-Christophe, Bayle, Frédérique, Bourdin, Gael, Leray, Véronique, Debord, Sophie, Delannoy, Bertrand, Stoian, Alina Cividjian, Wallet, Florent, Yonis, Hodane, and Guerin, Claude
- Abstract
Associated treatments.
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- 2021
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97. Additional file 6 of Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial
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Richard, Jean-Christophe, Yonis, Hodane, Bitker, Laurent, Roche, Sylvain, Wallet, Florent, Dupuis, Claire, Serrier, Hassan, Argaud, Laurent, Thiery, Guillaume, Delannoy, Bertrand, Pommier, Christian, Abraham, Paul, Muller, Michel, Aubrun, Frederic, Sigaud, Florian, Rigault, Guillaume, Joffredo, Emilie, Mezidi, Mehdi, Terzi, Nicolas, and Rabilloud, Muriel
- Abstract
Additional file 6. Case report form.
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- 2021
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98. BMI and pneumonia outcomes in critically ill COVID-19 patients : an international multicenter study
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Chetboun, Mikael, Raverdy, Violeta, Labreuche, Julien, Simonnet, Arthur, Wallet, Florent, Caussy, Cyrielle, Antonelli, Massimo, Artigas, Antonio, Goma, Gemma, Meziani, Ferhat, Helms, Julie, Mylonakis, Eleftherios, Levy, Mitchell M., Kalligeros, Markos, Latronico, Nicola, Piva, Simone, Cerf, Charles, Neuville, Mathilde, Klouche, Kada, Larcher, Romaric, Tamion, Fabienne, Occhiali, Emilie, Snacken, Morgane, Preiser, Jean-Charles, Kontar, Loay, Riviere, Antoine, Silva, Stein, Sarton, Benjamine, Krouchi, Raphael, Dubar, Victoria, Palaiodimos, Leonidas, Karamanis, Dimitrios, Perche, Juliette, L'her, Erwan, Busetto, Luca, Dicker, Dror, Lev, Shaul, Duhamel, Alain, Jourdain, Mercè, Pattou, François, Chetboun, Mikael, Raverdy, Violeta, Labreuche, Julien, Simonnet, Arthur, Wallet, Florent, Caussy, Cyrielle, Antonelli, Massimo, Artigas, Antonio, Goma, Gemma, Meziani, Ferhat, Helms, Julie, Mylonakis, Eleftherios, Levy, Mitchell M., Kalligeros, Markos, Latronico, Nicola, Piva, Simone, Cerf, Charles, Neuville, Mathilde, Klouche, Kada, Larcher, Romaric, Tamion, Fabienne, Occhiali, Emilie, Snacken, Morgane, Preiser, Jean-Charles, Kontar, Loay, Riviere, Antoine, Silva, Stein, Sarton, Benjamine, Krouchi, Raphael, Dubar, Victoria, Palaiodimos, Leonidas, Karamanis, Dimitrios, Perche, Juliette, L'her, Erwan, Busetto, Luca, Dicker, Dror, Lev, Shaul, Duhamel, Alain, Jourdain, Mercè, and Pattou, François
- Abstract
Previous studies unveiled a relation between the severity of COVID-19 pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, current smoking) in critically ill patients with COVID-19. This multicenter retrospective cohort study enrolled patients admitted in intensive care for COVID-19, in 21 centers (Europe, Israel, USA) between 02/19/2020 and 05/19/2020. Primary and secondary outcomes were the need for invasive mechanical ventilation (IMV), and 28-day mortality. A total of 1,461 patients were enrolled, median(IQR) age was 64 years (40.9-72.0); 73.2% males; BMI 28.1 kg/m 2 (25.4-32.3); 1,080 patients (73.9%) required IMV; the 28-day mortality estimate was 36.1% (95%CI, 33.0-39.5). Adjusted mixed logistic regression model showed a significant linear relation between BMI and IMV: OR 1.27 (95%CI, 1.12-1.45) per 5 kg/m 2. Adjusted Cox proportional hazards regression model showed a significant association between BMI and mortality, which was only increased in obesity class III (≥40 kg/m 2) (HR 1.68 (95%CI 1.06-2.64). In critically ill COVID-19 patients, we observed a linear association between BMI and the need for IMV, independent of other metabolic risk factors, and a non-linear association between BMI and mortality risk. (NCT04391738).
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- 2021
99. Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure
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Lemiale, Virginie, Dumas, Guillaume, Demoule, Alexandre, Pène, Frédéric, Kouatchet, Achille, Bisbal, Magali, Nseir, Saad, Argaud, Laurent, Kontar, Loay, Klouche, Kada, Barbier, François, Seguin, Amélie, Louis, Guillaume, Constantin, Jean Michel, Mayaux, Julien, Wallet, Florent, Peigne, Vincent, Girault, Christophe, Oziel, Johanna, Nyunga, Martine, Terzi, Nicolas, Bouadma, Lila, Lautrette, Alexandre, Bige, Naike, Raphalen, Jean Herle, Papazian, Laurent, Bruneel, Fabrice, Lebert, Christine, Benoit, Dominique, Meert, Anne-Pascale, Jaber, Samir, Mokart, Djamel, Darmon, Michael, Azoulay, Elie, Lemiale, Virginie, Dumas, Guillaume, Demoule, Alexandre, Pène, Frédéric, Kouatchet, Achille, Bisbal, Magali, Nseir, Saad, Argaud, Laurent, Kontar, Loay, Klouche, Kada, Barbier, François, Seguin, Amélie, Louis, Guillaume, Constantin, Jean Michel, Mayaux, Julien, Wallet, Florent, Peigne, Vincent, Girault, Christophe, Oziel, Johanna, Nyunga, Martine, Terzi, Nicolas, Bouadma, Lila, Lautrette, Alexandre, Bige, Naike, Raphalen, Jean Herle, Papazian, Laurent, Bruneel, Fabrice, Lebert, Christine, Benoit, Dominique, Meert, Anne-Pascale, Jaber, Samir, Mokart, Djamel, Darmon, Michael, and Azoulay, Elie
- Abstract
Background: Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in immunocompromised patients, including all patients who received high-flow nasal cannula (HFNC). The first objective was to evaluate the accuracy of the ROX index to predict intubation for patients with acute respiratory failure. Results: In the study, 302 patients received HFNC. Acute respiratory failure was mostly related to pneumonia (n = 150, 49.7%). Within 2 (1–3) days, 115 (38.1%) patients were intubated. The ICU mortality rate was 27.4% (n = 83). At 6 h, the ROX index was lower for patients who needed intubation compared with those who did not [4.79 (3.69–7.01) vs. 6.10 (4.48–8.68), p < 0.001]. The accuracy of the ROX index to predict intubation was poor [AUC = 0.623 (0.557–0.689)], with low performance using the threshold previously found (4.88). In multivariate analysis, a higher ROX index was still independently associated with a lower intubation rate (OR = 0.89 [0.82–0.96], p = 0.04). Conclusion: A ROX index greater than 4.88 appears to have a poor ability to predict intubation in immunocompromised patients with acute respiratory failure, although it remains highly associated with the risk of intubation and may be useful to stratify such risk in future studies., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2021
100. Prevalence of obesity among adult inpatients with COVID-19 in France
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Caussy, Cyrielle, Pattou, François, Wallet, Florent, Simon, Chantal, Chalopin, Sarah, Telliam, Charlène, Mathieu, Daniel, Subtil, Fabien, Frobert, Emilie, Alligier, Maud, Delaunay, Dominique, Vanhems, Philippe, Laville, Martine, Jourdain, Merce, and Disse, Emmanuel
- Published
- 2020
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