51. CD4(+) T cell responses to cytomegalovirus in early life: a prospective birth cohort study.
- Author
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Miles, David J C, Sande, Marianne van der, Kaye, Steve, Crozier, Sarah, Ojuola, Olubukola, Palmero, Melba, Sanneh, Mariama, Touray, Ebrima S, Waight, Pauline, Rowland-Jones, Sarah, Whittle, Hilton, Marchant, Arnaud, Miles, David J C, Sande, Marianne van der, Kaye, Steve, Crozier, Sarah, Ojuola, Olubukola, Palmero, Melba, Sanneh, Mariama, Touray, Ebrima S, Waight, Pauline, Rowland-Jones, Sarah, Whittle, Hilton, and Marchant, Arnaud
- Abstract
We compared cytomegalovirus (CMV)-specific interferon-gamma (IFN-gamma), interleukin 2 (IL-2), and CD154 CD4(+) T cell responses of infants to those from chronically infected adults and from children aged 4-5 years. Magnitudes of the responses were similar, although coexpression of IFN-gamma plus CD154 occurred more than coexpression of IFN-gamma plus IL-2 or IL-2 plus CD154. Responses remained constant during infancy, although the proportion of IFN-gamma-producing cells increased from infancy to adulthood. Most responding cells in infants were undifferentiated (i.e. CD27(+)CD28(+)), although IFN-gamma-producing cells were disproportionately CD27(-). By 12 months after diagnosis, viremia was rarely detectable, indicating that CMV was controlled despite the slow development of CMV-specific CD4(+) T cell responses., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2008