4,420 results on '"WU, P-C"'
Search Results
52. LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase
- Author
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Zeng, Judeng, Xie, Chuan, Huang, Ziheng, Cho, Chi H., Chan, Hung, Li, Qing, Ashktorab, Hassan, Smoot, Duane T., Wong, Sunny H., Yu, Jun, Gong, Wei, Liang, Cong, Xu, Hongzhi, Chen, Huarong, Liu, Xiaodong, Wu, Justin C. Y., Ip, Margaret, Gin, Tony, Zhang, Lin, Chan, Matthew T. V., Hu, Wei, and Wu, William K. K.
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- 2024
- Full Text
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53. Individualized monitoring of longitudinal heading exposure in soccer
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Kenny, Rebecca, Elez, Marko, Clansey, Adam, Virji-Babul, Naznin, and Wu, Lyndia C.
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- 2024
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54. Giant Modulation of Refractive Index from Picoscale Atomic Displacements
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Zhao, Boyang, Ren, Guodong, Mei, Hongyan, Wu, Vincent C., Singh, Shantanu, Jung, Gwan-Yeong, Chen, Huandong, Giovine, Raynald, Niu, Shanyuan, Thind, Arashdeep S., Salman, Jad, Settineri, Nick S., Chakoumakos, Bryan C., Manley, Michael E., Hermann, Raphael P., Lupini, Andrew R., Chi, Miaofang, Hachtel, Jordan A., Simonov, Arkadiy, Teat, Simon J., Clément, Raphaële J., Kats, Mikhail A., Ravichandran, J., and Mishra, Rohan
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Structural disorder has been shown to enhance and modulate magnetic, electrical, dipolar, electrochemical, and mechanical properties of materials. However, the possibility of obtaining novel optical and optoelectronic properties from structural disorder remains an open question. Here, we show unambiguous evidence of disorder in the form of anisotropic, picoscale atomic displacements modulating the refractive index tensor and resulting in the giant optical anisotropy observed in BaTiS$_3$, a quasi-one-dimensional hexagonal chalcogenide. Single crystal X-ray diffraction studies reveal the presence of antipolar displacements of Ti atoms within adjacent TiS$_6$ chains along the c-axis, and three-fold degenerate Ti displacements in the a-b plane. $^{47/49}$Ti solid-state NMR provides additional evidence for those Ti displacements in the form of a three-horned NMR lineshape resulting from a low symmetry local environment around Ti atoms. We used scanning transmission electron microscopy to directly observe the globally disordered Ti a-b plane displacements and find them to be ordered locally over a few unit cells. First-principles calculations show that the Ti a-b plane displacements selectively reduce the refractive index along the ab-plane, while having minimal impact on the refractive index along the chain direction, thus resulting in a giant enhancement in the optical anisotropy. By showing a strong connection between structural disorder with picoscale displacements and the optical response in BaTiS$_3$, this study opens a pathway for designing optical materials with high refractive index and functionalities such as large optical anisotropy and nonlinearity., Comment: 24 pages, 3 figures
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- 2023
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55. Tidal migration of exoplanets around M-dwarfs: frequency-dependent tidal dissipation
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Wu, Samantha C., Dewberry, Janosz W., and Fuller, Jim
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The orbital architectures of short-period exoplanet systems are shaped by tidal dissipation in their host stars. For low-mass M-dwarfs whose dynamical tidal response comprises a dense spectrum of inertial modes at low frequencies, resolving the frequency dependence of tidal dissipation is crucial to capturing the effect of tides on planetary orbits throughout the evolutionary stages of the host star. We use non-perturbative spectral methods to calculate the normal mode oscillations of a fully-convective M-dwarf modeled using realistic stellar profiles from MESA. We compute the dissipative tidal response composed of contributions from each mode as well as non-adiabatic coupling between the modes, which we find to be an essential component of the dissipative calculations. Using our results for dissipation, we then compute of the evolution of circular, coplanar planetary orbits under the influence of tides in the host star. We find that orbital migration driven by resonance locking affects the orbits of Earth-mass planets at orbital periods $P_{\rm orb} \lesssim 1.5$ day and of Jupiter-mass planets at $P_{\rm orb} \lesssim 2.5$ day. Due to resonantly-driven orbital decay and outward migration, we predict a dearth of small planets closer than $P_{\rm orb} \sim 1$ day and similarly sparse numbers of more massive planets out to $P_{\rm orb} \sim 3$ day., Comment: Accepted in ApJ
- Published
- 2023
56. Generating scalable graph states in an atom-nanophotonic interface
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Chien, C. -H., Goswami, S., Wu, C. -C., Hiew, W. -S., Chen, Y. -C., and Jen, H. H.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Atomic Physics - Abstract
Scalable graph states are essential for measurement-based quantum computation and many entanglement-assisted applications in quantum technologies. Generation of these multipartite entangled states requires a controllable and efficient quantum device with delicate design of generation protocol. Here we propose to prepare high-fidelity and scalable graph states in one and two dimensions, which can be tailored in an atom-nanophotonic cavity via state carving technique. We propose a systematic protocol to carve out unwanted state components, which facilitates scalable graph states generations via adiabatic transport of a definite number of atoms in optical tweezers. An analysis of state fidelity is also presented, and the state preparation probability can be optimized via multiqubit state carvings and sequential single-photon probes. Our results showcase the capability of an atom-nanophotonic interface for creating graph states and pave the way toward novel problem-specific applications using scalable high-dimensional graph states with stationary qubits., Comment: 5 figures with supplemental material
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- 2023
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57. Atomic excitation delocalization at the clean to disordered interface in a chirally-coupled atomic array
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Wu, C. -C., Lin, K. -T., Handayana, I G. N. Y., Chien, C. -H., Goswami, S., Lin, G. -D., Chen, Y. -C., and Jen, H. H.
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Quantum Physics ,Physics - Atomic Physics - Abstract
In one-dimensional quantum emitter systems, the dynamics of atomic excitations are influenced by the collective coupling between emitters through photon-mediated dipole-dipole interactions. By introducing positional disorders in a portion of the atomic array, we investigate the delocalization phenomena at the interface between disordered zone and clean zone. The excitation is initialized as symmetric Dicke states in the disordered zone, and several measures are used to quantify the excitation localization. We first use population imbalance and half-chain entropy to investigate the excitation dynamics under time evolutions, and further investigate the crossover of excitation localization to delocalization via the gap ratio from the eigenspectrum in the reciprocal coupling case. In particular, we study the participation ratio of the whole chain and the photon loss ratio between both ends of the atomic chain, which can be used to quantify the delocalization crossover in the non-reciprocal coupling cases. Furthermore, by increasing the overall size or the ratio of the disordered zone under a fixed number of the whole chain, we observe that excitation localization occurs at a smaller disorder strength in the former case, while in the latter, a facilitation of the delocalization appears when a significant ratio of clean zone to disordered zone is applied. Our results can reveal the competition between the clean zone and the disordered zone sizes on localization phenomenon, give insights to non-equilibrium dynamics in the emitter-waveguide interface, and provide potential applications in quantum information processing.
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- 2023
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58. Experimental Limits on Solar Reflected Dark Matter with a New Approach on Accelerated-Dark-Matter-Electron Analysis in Semiconductors
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Zhang, Z. Y., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, T., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jiang, L., Karmakar, S., Li, H. B., Li, H. Y., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, J. X., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., Singh, M. K., Sun, T. X., Tang, C. J., Tian, Y., Wang, G. F., Wang, J. Z., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhao, J. Z., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
- Subjects
High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Instrumentation and Detectors - Abstract
Recently a dark matter-electron (DM-electron) paradigm has drawn much attention. Models beyond the standard halo model describing DM accelerated by high energy celestial bodies are under intense examination as well. In this Letter, a velocity components analysis (VCA) method dedicated to swift analysis of accelerated DM-electron interactions via semiconductor detectors is proposed and the first HPGe detector-based accelerated DM-electron analysis is realized. Utilizing the method, the first germanium based constraint on sub-GeV solar reflected DM-electron interaction is presented with the 205.4 kg$\cdot$day dataset from the CDEX-10 experiment. In the heavy mediator scenario, our result excels in the mass range of 5$-$15 keV/$c^2$, achieving a 3 orders of magnitude improvement comparing with previous semiconductor experiments. In the light mediator scenario, the strongest laboratory constraint for DM lighter than 0.1 MeV/$c^2$ is presented. The result proves the feasibility and demonstrates the vast potential of the VCA technique in future accelerated DM-electron analyses with semiconductor detectors., Comment: 7 pages, 4 figures. Version updated to match PRL version
- Published
- 2023
- Full Text
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59. SARS-CoV-2 Wastewater Genomic Surveillance: Approaches, Challenges, and Opportunities
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Munteanu, Viorel, Saldana, Michael, Ciorba, Dumitru, Bostan, Viorel, Su, Justin Maine, Kasianchuk, Nadiia, Sharma, Nitesh Kumar, Knyazev, Sergey, Gordeev, Victor, Aßmann, Eva, Lobiuc, Andrei, Covasa, Mihai, Crandall, Keith A., Ouyang, Wenhao O., Wu, Nicholas C., Mason, Christopher, Tierney, Braden T, Lucaci, Alexander G, Zelikovsky, Alex, Mohebbi, Fatemeh, Skums, Pavel, Gibas, Cynthia, Schlueter, Jessica, Rzymski, Piotr, Solo-Gabriele, Helena, Hölzer, Martin, Smith, Adam, and Mangul, Serghei
- Subjects
Quantitative Biology - Genomics - Abstract
During the SARS-CoV-2 pandemic, wastewater-based genomic surveillance (WWGS) emerged as an efficient viral surveillance tool that takes into account asymptomatic cases and can identify known and novel mutations and offers the opportunity to assign known virus lineages based on the detected mutations profiles. WWGS can also hint towards novel or cryptic lineages, but it is difficult to clearly identify and define novel lineages from wastewater (WW) alone. While WWGS has significant advantages in monitoring SARS-CoV-2 viral spread, technical challenges remain, including poor sequencing coverage and quality due to viral RNA degradation. As a result, the viral RNAs in wastewater have low concentrations and are often fragmented, making sequencing difficult. WWGS analysis requires advanced computational tools that are yet to be developed and benchmarked. The existing bioinformatics tools used to analyze wastewater sequencing data are often based on previously developed methods for quantifying the expression of transcripts or viral diversity. Those methods were not developed for wastewater sequencing data specifically, and are not optimized to address unique challenges associated with wastewater. While specialized tools for analysis of wastewater sequencing data have also been developed recently, it remains to be seen how they will perform given the ongoing evolution of SARS-CoV-2 and the decline in testing and patient-based genomic surveillance. Here, we discuss opportunities and challenges associated with WWGS, including sample preparation, sequencing technology, and bioinformatics methods., Comment: V Munteanu and M Saldana contributed equally to this work. M H\"olzer, A Smith and S Mangul jointly supervised this work. For correspondence: serghei.mangul@gmail.com
- Published
- 2023
60. On the damping of tidally driven oscillations
- Author
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Dewberry, Janosz W. and Wu, Samantha C.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Physics - Fluid Dynamics - Abstract
Expansions in the oscillation modes of tidally perturbed bodies provide a useful framework for representing tidally induced flows. However, recent work has demonstrated that such expansions produce inaccurate predictions for secular orbital evolution when mode damping rates are computed independently. We explore the coupling of collectively driven modes by frictional and viscous dissipation, in tidally perturbed bodies that are both non-rotating and rigidly rotating. This exploration leads us to propose an alternative approach to treating the damping of tidally driven oscillations that accounts for dissipative mode coupling, but which does not require any information beyond the eigenfunctions and eigenfrequencies of adiabatic modes., Comment: 9 pages, 7 figures, revised after submission to MNRAS (comments welcome)
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- 2023
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61. Projected WIMP sensitivity of the CDEX-50 dark matter experiment
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Geng, X. P., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Gong, H., Guo, Q. J., Guo, T., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jiang, L., Karmakar, S., Li, H. B., Li, H. Y., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, J. X., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., Singh, M. K., Sun, T. X., Tang, C. J., Tian, Y., Wang, G. F., Wang, J. Z., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhang, Z. Y., Zhao, J. Z., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
- Subjects
High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
CDEX-50 is a next-generation project of the China Dark Matter Experiment (CDEX) that aims to search for dark matter using a 50-kg germanium detector array. This paper comprises a thorough summary of the CDEX-50 dark matter experiment, including an investigation of potential background sources and the development of a background model. Based on the baseline model, the projected sensitivity of weakly interacting massive particle (WIMP) is also presented. The expected background level within the energy region of interest, set to 2--2.5 keVee, is $\sim$0.01 counts keVee$^{-1}$ kg$^{-1}$ day$^{-1}$. At 90\% confidence level, the expected sensitivity to spin-independent WIMP-nucleon couplings is estimated to reach a cross-section of 5.1 $\times$ 10$^{-45}$ cm$^{2}$ for a WIMP mass of 5 GeV/c$^{2}$ with an exposure objective of 150 kg$\cdot$year and an analysis threshold of 160 eVee. This science goal will correspond to the most sensitive results for WIMPs with a mass of 2.2--8 GeV/c$^{2}$., Comment: 12 pages, 11 figures. Version updated to match JCAP version
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- 2023
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- View/download PDF
62. Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations
- Author
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Zhang, Mao, Venkateshappa, Ravichandra, Li, Audrey, Fowler, Michael B, Telli, Melinda L, and Wu, Joseph C
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Stem Cell Research - Induced Pluripotent Stem Cell - Human ,Breast Cancer ,Cancer ,Stem Cell Research - Induced Pluripotent Stem Cell ,Genetics ,Regenerative Medicine ,Clinical Research ,Women's Health ,Stem Cell Research ,2.1 Biological and endogenous factors ,Humans ,Female ,Induced Pluripotent Stem Cells ,Breast Neoplasms ,Leukocytes ,Mononuclear ,Mutation ,Germ-Line Mutation ,Ataxia Telangiectasia Mutated Proteins ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology ,Medical biotechnology ,Oncology and carcinogenesis - Abstract
We generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of breast cancer patients carrying germline ATM mutations, a gene associated with a 7% prevalence in breast cancer. These iPSC lines displayed typical morphology, expressed pluripotency markers, maintained a stable karyotype, and retained the ability to differentiate into the three germ layers. These patient-specific iPSC lines hold great potential for mechanistic investigations and the development of drug screening strategies aimed at addressing ATM-related cancer.
- Published
- 2023
63. Analysis of Oncology and Radiation Therapy Representation on the National Board of Medical Examiners Official Practice Material for the United States National Standardized Medical Board Examinations
- Author
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Mahoney, Mary T., Linkowski, Lauren C., Wu, Trudy C., Chen, Jie Jane, Neilsen, Beth K., Thompson, Petria S., Mix, Michael D., Sura, Karna T., and Mattes, Malcolm D.
- Published
- 2024
- Full Text
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64. FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare
- Author
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Lekadir, Karim, Feragen, Aasa, Fofanah, Abdul Joseph, Frangi, Alejandro F, Buyx, Alena, Emelie, Anais, Lara, Andrea, Porras, Antonio R, Chan, An-Wen, Navarro, Arcadi, Glocker, Ben, Botwe, Benard O, Khanal, Bishesh, Beger, Brigit, Wu, Carol C, Cintas, Celia, Langlotz, Curtis P, Rueckert, Daniel, Mzurikwao, Deogratias, Fotiadis, Dimitrios I, Zhussupov, Doszhan, Ferrante, Enzo, Meijering, Erik, Weicken, Eva, González, Fabio A, Asselbergs, Folkert W, Prior, Fred, Krestin, Gabriel P, Collins, Gary, Tegenaw, Geletaw S, Kaissis, Georgios, Misuraca, Gianluca, Tsakou, Gianna, Dwivedi, Girish, Kondylakis, Haridimos, Jayakody, Harsha, Woodruf, Henry C, Mayer, Horst Joachim, Aerts, Hugo JWL, Walsh, Ian, Chouvarda, Ioanna, Buvat, Irène, Tributsch, Isabell, Rekik, Islem, Duncan, James, Kalpathy-Cramer, Jayashree, Zahir, Jihad, Park, Jinah, Mongan, John, Gichoya, Judy W, Schnabel, Julia A, Kushibar, Kaisar, Riklund, Katrine, Mori, Kensaku, Marias, Kostas, Amugongo, Lameck M, Fromont, Lauren A, Maier-Hein, Lena, Alberich, Leonor Cerdá, Rittner, Leticia, Phiri, Lighton, Marrakchi-Kacem, Linda, Donoso-Bach, Lluís, Martí-Bonmatí, Luis, Cardoso, M Jorge, Bobowicz, Maciej, Shabani, Mahsa, Tsiknakis, Manolis, Zuluaga, Maria A, Bielikova, Maria, Fritzsche, Marie-Christine, Camacho, Marina, Linguraru, Marius George, Wenzel, Markus, De Bruijne, Marleen, Tolsgaard, Martin G, Ghassemi, Marzyeh, Ashrafuzzaman, Md, Goisauf, Melanie, Yaqub, Mohammad, Abadía, Mónica Cano, Mahmoud, Mukhtar M E, Elattar, Mustafa, Rieke, Nicola, Papanikolaou, Nikolaos, Lazrak, Noussair, Díaz, Oliver, Salvado, Olivier, Pujol, Oriol, Sall, Ousmane, Guevara, Pamela, Gordebeke, Peter, Lambin, Philippe, Brown, Pieta, Abolmaesumi, Purang, Dou, Qi, Lu, Qinghua, Osuala, Richard, Nakasi, Rose, Zhou, S Kevin, Napel, Sandy, Colantonio, Sara, Albarqouni, Shadi, Joshi, Smriti, Carter, Stacy, Klein, Stefan, Petersen, Steffen E, Aussó, Susanna, Awate, Suyash, Raviv, Tammy Riklin, Cook, Tessa, Mutsvangwa, Tinashe E M, Rogers, Wendy A, Niessen, Wiro J, Puig-Bosch, Xènia, Zeng, Yi, Mohammed, Yunusa G, Aquino, Yves Saint James, Salahuddin, Zohaib, and Starmans, Martijn P A
- Subjects
Computer Science - Computers and Society ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,I.2.0 ,I.4.0 ,I.5.0 - Abstract
Despite major advances in artificial intelligence (AI) for medicine and healthcare, the deployment and adoption of AI technologies remain limited in real-world clinical practice. In recent years, concerns have been raised about the technical, clinical, ethical and legal risks associated with medical AI. To increase real world adoption, it is essential that medical AI tools are trusted and accepted by patients, clinicians, health organisations and authorities. This work describes the FUTURE-AI guideline as the first international consensus framework for guiding the development and deployment of trustworthy AI tools in healthcare. The FUTURE-AI consortium was founded in 2021 and currently comprises 118 inter-disciplinary experts from 51 countries representing all continents, including AI scientists, clinicians, ethicists, and social scientists. Over a two-year period, the consortium defined guiding principles and best practices for trustworthy AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. The FUTURE-AI framework was established based on 6 guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 28 best practices were defined, addressing technical, clinical, legal and socio-ethical dimensions. The recommendations cover the entire lifecycle of medical AI, from design, development and validation to regulation, deployment, and monitoring. FUTURE-AI is a risk-informed, assumption-free guideline which provides a structured approach for constructing medical AI tools that will be trusted, deployed and adopted in real-world practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of medical AI.
- Published
- 2023
65. Multivariate Differential Association Analysis
- Author
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Song, Hoseung and Wu, Michael C.
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Statistics - Methodology - Abstract
Identifying how dependence relationships vary across different conditions plays a significant role in many scientific investigations. For example, it is important for the comparison of biological systems to see if relationships between genomic features differ between cases and controls. In this paper, we seek to evaluate whether the relationships between two sets of variables is different across two conditions. Specifically, we assess: do two sets of high-dimensional variables have similar dependence relationships across two conditions?. We propose a new kernel-based test to capture the differential dependence. Specifically, the new test determines whether two measures that detect dependence relationships are similar or not under two conditions. We introduce the asymptotic permutation null distribution of the test statistic and it is shown to work well under finite samples such that the test is computationally efficient, making it easily applicable to analyze large data sets. We demonstrate through numerical studies that our proposed test has high power for detecting differential linear and non-linear relationships. The proposed method is implemented in an R package kerDAA.
- Published
- 2023
66. Magnetic structure and Kondo lattice behavior in CeVGe$_3$: an NMR and neutron scattering study
- Author
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Chaffey, C., Wu, H. C., Jin, Hanshang, Sherpa, P., Klavins, Peter, Avdeev, M., Aji, S., Shimodate, R., Nawa, K., Sato, T. J., Taufour, V., and Curro, N. J.
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
We present nuclear magnetic resonance (NMR), neutron diffraction, magnetization, and transport measurements on a single crystal and powder of CeVGe$_3$. This material exhibits heavy fermion behavior at low temperature, accompanied by antiferromagnetic (AFM) order below 5.8 K. We find that the magnetic structure is incommensurate with AFM helical structure, characterized by a magnetic modulated propagation vector of $(0, 0, 0.49)$ with in-plane moments rotating around the $c$-axis. The NMR Knight shift and spin-lattice relaxation rate reveal a coherence temperature $T^*\sim 15$ K, and the presence of significant antiferromagnetic fluctuations reminiscent of the archetypical heavy fermion compound CeRhIn$_5$. We further identify a metamagnetic transition above $H_m\sim 2.5$ T for magnetic fields perpendicular to $c$. We speculate that the magnetic structure in this field-induced phase consists of a superposition with both ferromagnetic and antiferromagnetic components, which is consistent with the NMR spectrum in this region of the phase diagram. Our results thus indicate that CeVGe$_3$ is a hexagonal structure analog to tetragonal CeRhIn$_5$., Comment: 13 pages, 11 figures
- Published
- 2023
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67. Studying Long QT Syndrome Caused by NAA10 Genetic Variants Using Patient-Derived Induced Pluripotent Stem Cells
- Author
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Belbachir, Nadjet, Wu, Yiyang, Shen, Mengcheng, Zhang, Sophia L, Zhang, Joe Z, Liu, Chun, Knollmann, Bjorn C, Lyon, Gholson J, Ma, Ning, and Wu, Joseph C
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Stem Cell Research - Induced Pluripotent Stem Cell ,Stem Cell Research - Embryonic - Human ,Congenital Heart Disease ,Pediatric ,Cardiovascular ,Stem Cell Research - Nonembryonic - Human ,Genetics ,Stem Cell Research ,Heart Disease ,Rare Diseases ,Stem Cell Research - Induced Pluripotent Stem Cell - Human ,2.1 Biological and endogenous factors ,Humans ,Induced Pluripotent Stem Cells ,Long QT Syndrome ,Phenotype ,Myocytes ,Cardiac ,Mutation ,N-Terminal Acetyltransferase A ,N-Terminal Acetyltransferase E ,Cav1.2 calcium channel ,NAA10 ,iPSC ,long QT ,rare disease ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Sports science and exercise - Published
- 2023
68. Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA2 variants
- Author
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Zhang, Mao, Liu, Wenqiang, Li, Audrey, Htet, Min H, Yu, Rebecca, Telli, Melinda L, and Wu, Joseph C
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Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Oncology and Carcinogenesis ,Women's Health ,Stem Cell Research - Induced Pluripotent Stem Cell ,Breast Cancer ,Cancer ,Stem Cell Research ,Stem Cell Research - Induced Pluripotent Stem Cell - Human ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Humans ,Female ,Breast Neoplasms ,Genes ,BRCA2 ,Induced Pluripotent Stem Cells ,Germ-Line Mutation ,Mutation ,BRCA2 Protein ,Medical and Health Sciences ,Developmental Biology ,Medical biotechnology ,Oncology and carcinogenesis - Abstract
Germline pathogenic variants in the BRCA2 gene are strongly correlated with an elevated risk of developing breast cancer. Two specific BRCA2 variants, c.8167G>C (p.Asp2723His) and c.1583del (p.Asn528fs), have been identified from individuals with a family history of breast cancer. Here we generated two iPSC lines from breast cancer patients who are heterozygous carriers of these two variants. These iPSCs exhibit pluripotency and demonstrate the capability to differentiate into three germ layers. These iPSC lines represent a valuable resource for personalized pre-clinical research, offering new opportunities to explore the underlying mechanisms of breast cancer and develop targeted therapeutic approaches.
- Published
- 2023
69. Ipilimumab with or without nivolumab in PD-1 or PD-L1 blockade refractory metastatic melanoma: a randomized phase 2 trial
- Author
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VanderWalde, Ari, Bellasea, Shay L, Kendra, Kari L, Khushalani, Nikhil I, Campbell, Katie M, Scumpia, Philip O, Kuklinski, Lawrence F, Collichio, Frances, Sosman, Jeffrey A, Ikeguchi, Alexandra, Victor, Adrienne I, Truong, Thach-Giao, Chmielowski, Bartosz, Portnoy, David C, Chen, Yuanbin, Margolin, Kim, Bane, Charles, Dasanu, Constantin A, Johnson, Douglas B, Eroglu, Zeynep, Chandra, Sunandana, Medina, Egmidio, Gonzalez, Cynthia R, Baselga-Carretero, Ignacio, Vega-Crespo, Agustin, Garcilazo, Ivan Perez, Sharon, Elad, Hu-Lieskovan, Siwen, Patel, Sapna P, Grossmann, Kenneth F, Moon, James, Wu, Michael C, and Ribas, Antoni
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Cancer ,Clinical Research ,Patient Safety ,Minority Health ,Clinical Trials and Supportive Activities ,6.1 Pharmaceuticals ,Humans ,B7-H1 Antigen ,CTLA-4 Antigen ,Ipilimumab ,Melanoma ,Nivolumab ,Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
In this randomized phase 2 trial, blockade of cytotoxic T-lymphocyte protein 4 (CTLA-4) with continuation of programmed death protein 1 (PD-1) blockade in patients with metastatic melanoma who had received front-line anti-PD-1 or therapy against programmed cell death 1 ligand 1 and whose tumors progressed was tested in comparison with CTLA-4 blockade alone. Ninety-two eligible patients were randomly assigned in a 3:1 ratio to receive the combination of ipilimumab and nivolumab, or ipilimumab alone. The primary endpoint was progression-free survival. Secondary endpoints included the difference in CD8 T cell infiltrate among responding and nonresponding tumors, objective response rate, overall survival and toxicity. The combination of nivolumab and ipilimumab resulted in a statistically significant improvement in progression-free survival over ipilimumab (hazard ratio = 0.63, 90% confidence interval (CI) = 0.41-0.97, one-sided P = 0.04). Objective response rates were 28% (90% CI = 19-38%) and 9% (90% CI = 2-25%), respectively (one-sided P = 0.05). Grade 3 or higher treatment-related adverse events occurred in 57% and 35% of patients, respectively, which is consistent with the known toxicity profile of these regimens. The change in intratumoral CD8 T cell density observed in the present analysis did not reach statistical significance to support the formal hypothesis tested as a secondary endpoint. In conclusion, primary resistance to PD-1 blockade therapy can be reversed in some patients with the combination of CTLA-4 and PD-1 blockade. Clinicaltrials.gov identifier: NCT03033576 .
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- 2023
70. Author Correction: Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum
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Yang, Yang, Valencia, Luis A., Lu, Chih-Hao, Nakamoto, Melissa L., Tsai, Ching-Ting, Liu, Chun, Yang, Huaxiao, Zhang, Wei, Jahed, Zeinab, Lee, Wan-Ru, Santoro, Francesca, Liou, Jen, Wu, Joseph C., and Cui, Bianxiao
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- 2024
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71. The Lobster Eye Imager for Astronomy Onboard the SATech-01 Satellite
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Ling, Z. X., Sun, X. J., Zhang, C., Sun, S. L., Jin, G., Zhang, S. N., Zhang, X. F., Chang, J. B., Chen, F. S., Chen, Y. F., Cheng, Z. W., Fu, W., Han, Y. X., Li, H., Li, J. F., Li, Y., Li, Z. D., Liu, P. R., Lv, Y. H., Ma, X. H., Tang, Y. J., Wang, C. B., Xie, R. J., Xue, Y. L., Yan, A. L., Zhang, Q., Bao, C. Y., Cai, H. B., Cheng, H. Q., Cui, C. Z., Dai, Y. F., Fan, D. W., Hu, H. B., Hu, J. W., Huang, M. H., Jia, Z. Q., Jin, C. C., Li, D. Y., Li, J. Q., Liu, H. Y., Liu, M. J., Liu, Y., Pan, H. W., Qiu, Y. L., Sugizaki, M., Sun, H., Wang, W. X., Wang, Y. L., Wu, Q. Y., Xu, X. P., Xu, Y. F., Yang, H. N., Yang, X., Zhang, B., Zhang, M., Zhang, W. D., Zhang, Z., Zhao, D. H., Cong, X. Q., Jiang, B. W., Li, L. H., Qiu, X. B., Sun, J. N., Su, D. T., Wang, J., Wu, C., Xu, Z., Yang, X. M., Zhang, S. K., Zhang, N., Zhu, Y. F., Ban, H. Y., Bi, X. Z., Cai, Z. M., Chen, W., Chen, X., Chen, Y. H., Cui, Y., Duan, X. L., Feng, Z. G, Gao, Y., He, J. W., He, T., Huang, J. J., Li, F., Li, J. S., Li, T. J., Li, T. T., Liu, H. Q., Liu, L., Liu, R., Liu, S., Meng, N., Shi, Q., Sun, A. T., Wang, Y. M., Wang, Y. B., Wu, H. C., Xu, D. X, Yang, Y. Q, Yang, Y., Yu, X. S., Zhang, K. X., Zhang, Y. L., Zhang, Y. H., Zhang, Y. T., Zhou, H., Zhu, X. C., Cheng, J. S., Qin, L., Wang, L., Wang, Q. L., Bai, M., Gao, R. L., Ji, Z., Liu, Y. R., Ma, F. L., Shi, Y. J., Su, J., Tan, Y. Y., Tong, J. Z., Xu, H. T., Xue, C. B., Xue, G. F., and Yuan, W.
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Astrophysics - Instrumentation and Methods for Astrophysics ,High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
The Lobster Eye Imager for Astronomy (LEIA), a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe (EP) mission, was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on 27 July 2022. In this paper, we introduce the design and on-ground test results of the LEIA instrument. Using state-of-the-art Micro-Pore Optics (MPO), a wide field-of-view (FoV) of 346 square degrees (18.6 degrees * 18.6 degrees) of the X-ray imager is realized. An optical assembly composed of 36 MPO chips is used to focus incident X-ray photons, and four large-format complementary metal-oxide semiconductor (CMOS) sensors, each of 6 cm * 6 cm, are used as the focal plane detectors. The instrument has an angular resolution of 4 - 8 arcmin (in FWHM) for the central focal spot of the point spread function, and an effective area of 2 - 3 cm2 at 1 keV in essentially all the directions within the field of view. The detection passband is 0.5 - 4 keV in the soft X-rays and the sensitivity is 2 - 3 * 10-11 erg s-1 cm-2 (about 1 mini-Crab) at 1,000 second observation. The total weight of LEIA is 56 kg and the power is 85 W. The satellite, with a design lifetime of 2 years, operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 minutes. LEIA is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for X-ray observation, and by optimizing the working setups of the instrumental parameters. In addition, LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band, albeit limited useful observing time available., Comment: Accepted by RAA
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- 2023
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72. Searching for $^{76}$Ge neutrinoless double beta decay with the CDEX-1B experiment
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Zhang, B. T., Wang, J. Z., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Karmakar, S., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, J. X., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
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Nuclear Experiment ,High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
We operated a p-type point contact high purity germanium (PPCGe) detector (CDEX-1B, 1.008 kg) in the China Jinping Underground Laboratory (CJPL) for 500.3 days to search for neutrinoless double beta ($0\nu\beta\beta$) decay of $^{76}$Ge. A total of 504.3 kg$\cdot$day effective exposure data was accumulated. The anti-coincidence and the multi/single-site event (MSE/SSE) discrimination methods were used to suppress the background in the energy region of interest (ROI, 1989$-$2089 keV for this work) with a factor of 23. A background level of 0.33 counts/(keV$\cdot$kg$\cdot$yr) was realized. The lower limit on the half life of $^{76}$Ge $0\nu\beta\beta$ decay was constrained as $T_{1/2}^{0\nu}\ > \ {1.0}\times 10^{23}\ \rm yr\ (90\% \ C.L.)$, corresponding to the upper limits on the effective Majorana neutrino mass: $\langle m_{\beta\beta}\rangle < $3.2$-$7.5$\ \mathrm{eV}$., Comment: 11 pages, 12 figures, 2 tables. Version updated to match CPC version
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- 2023
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73. Direct experimental evidence of tunable charge transfer at the $LaNiO_{3}/CaMnO_{3}$ ferromagnetic interface
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Paudel, J. R., Terilli, M., Wu, T. -C., Grassi, J. D., Derrico, A. M., Sah, R. K., Kareev, M., Klewe, C., Shafer, P., Gloskovskii, A., Schlueter, C., Strocov, V. N., Chakhalian, J., and Gray, A. X.
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Condensed Matter - Materials Science - Abstract
Interfacial charge transfer in oxide heterostructures gives rise to a rich variety of electronic and magnetic phenomena. Designing heterostructures where one of the thin-film components exhibits a metal-insulator transition opens a promising avenue for controlling such phenomena both statically and dynamically. In this letter, we utilize a combination of depth-resolved soft X-ray standing-wave and hard X-ray photoelectron spectroscopies in conjunction with polarization-dependent X-ray absorption spectroscopy to investigate the effects of the metal-insulator transition in $LaNiO_{3}$ on the electronic and magnetic states at the $LaNiO_{3}/CaMnO_{3}$ interface. We report on a direct observation of the reduced effective valence state of the interfacial Mn cations in the metallic superlattice with an above-critical $LaNiO_{3}$ thickness (6 u.c.) due to the leakage of itinerant Ni 3d $e_{g}$ electrons into the interfacial $CaMnO_{3}$ layer. Conversely, in an insulating superlattice with a below-critical $LaNiO_{3}$ thickness of 2 u.c., a homogeneous effective valence state of Mn is observed throughout the $CaMnO_{3}$ layers due to the blockage of charge transfer across the interface. The ability to switch and tune interfacial charge transfer enables precise control of the emergent ferromagnetic state at the $LaNiO_{3}/CaMnO_{3}$ interface and, thus, has far-reaching consequences on the future strategies for the design of next-generation spintronic devices.
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- 2023
74. Low-temperature specific heat and heat transport of Tb$_2$Ti$_{2-x}$Zr$_x$O$_7$ single crystals
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Che, H. L., Li, S. J., Wu, J. C., Li, N., Guang, S. K., Xia, K., Yue, X. Y., Wang, Y. Y., Zhao, X., Li, Q. J., and Sun, X. F.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We report a study on the specific heat and heat transport of Tb$_2$Ti$_{2-x}$Zr$_x$O$_7$ ($x =$ 0, 0.02, 0.1, 0.2, and 0.4) single crystals at low temperatures and in high magnetic fields. The magnetic specific heat can be described by the Schottky contribution from the crystal-electric-field (CEF) levels of Tb$^{3+}$, with introducing Gaussian distributions of the energy split of the ground-state doublet and the gap between the ground state and first excited level. These crystals has an extremely low phonon thermal conductivity in a broad temperature range that can be attributed to the scattering by the magnetic excitations, which are mainly associated with the CEF levels. There is strong magnetic field dependence of thermal conductivity, which is more likely related to the field-induced changes of phonon scattering by the CEF levels than magnetic transitions or spin excitations. For magnetic field along the [111] direction, there is large thermal Hall conductivity at low temperatures which displays a broad peak around 8 T. At high fields up to 14 T, the thermal Hall conductivity decreases to zero, which supports its origin from either the spinon transport or the phonon skew scattering by CEF levels. The thermal Hall effect is rather robust with Zr doping up to 0.2 but is strongly weakened in higher Zr-doped sample., Comment: 9 pages, 8 figures, accepted for publication in Phys. Rev. B
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- 2023
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75. Reconstruction of Fast Neutron Direction in Segmented Organic Detectors using Deep Learning
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Bae, Jun Woo, Wu, Tingshiuan C., and Jovanovic, Igor
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Physics - Instrumentation and Detectors - Abstract
A method for reconstructing the direction of a fast neutron source using a segmented organic scintillator-based detector and deep learning model is proposed and analyzed. The model is based on recurrent neural network, which can be trained by a sequence of data obtained from an event recorded in the detector and suitably pre-processed. The performance of deep learning-based model is compared with the conventional double-scatter detection algorithm in reconstructing the direction of a fast neutron source. With the deep learning model, the uncertainty in source direction of 0.301 rad is achieved with 100 neutron detection events in a segmented cubic organic scintillator detector with a side length of 46 mm. To reconstruct the source direction with the same angular resolution as the double-scatter algorithm, the deep learning method requires 75% fewer events. Application of this method could augment the operation of segmented detectors operated in the neutron scatter camera configuration for applications such as special nuclear material detection., Comment: 15 pages. 9 figures. Preprint submitted to Elsevier August 2022
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- 2023
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76. Extension of Noether's theorem in PT-symmetric systems and its experimental demonstration in an optical setup
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Wu, Q. C., Zhao, J. L., Fang, Y. L., Zhang, Y., Chen, D. X., Yang, C. P., and Nori, F.
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Quantum Physics - Abstract
Noether's theorem is one of the fundamental laws in physics, relating the symmetry of a physical system to its constant of motion and conservation law. On the other hand, there exist a variety of non-Hermitian parity-time (PT)-symmetric systems, which exhibit novel quantum properties and have attracted increasing interest. In this work, we extend Noether's theorem to a class of significant PT -symmetric systems for which the eigenvalues of the PT-symmetric Hamiltonian H change from purely real numbers to purely imaginary numbers,and introduce a generalized expectation value of an operator based on biorthogonal quantum mechanics. We find that the generalized expectation value of a time-independent operator is a constant of motion when the operator presents a standard symmetry in the PT -symmetry unbroken regime, or a chiral symmetry in the PT-symmetry broken regime. In addition, we experimentally investigate the extended Noether's theorem in PT -symmetric single-qubit and two-qubit systems using an optical setup. Our experiment demonstrates the existence of the constant of motion and reveals how this constant of motion can be used to judge whether the PT -symmetry of a system is broken. Furthermore, a novel phenomenon of masking quantum information is first observed in a PT -symmetric two-qubit system. This study not only contributes to full understanding of the relation between symmetry and conservation law in PT -symmetric physics, but also has potential applications in quantum information theory and quantum communication protocols., Comment: 12 pages, 4 figures
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- 2023
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77. Merging binary black holes formed through double-core evolution
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Qin, Y., Hu, R. -C., Meynet, G., Wang, Y. Z., Zhu, J. -P., Song, H. F., Shu, X. W., and Wu, S. C.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,High Energy Physics - Phenomenology - Abstract
To date, various formation channels of merging events have been heavily explored with the detection of nearly 100 double black hole (BH) merger events reported by the LIGO-Virgo-KAGRA (LVK) Collaboration. We here systematically investigate an alternative formation scenario, i.e., binary BHs (BBHs) formed through double helium stars (hereafter double-core evolution channel). In this scenario, the two helium stars (He-rich stars) could be the outcome of the classical isolated binary evolution scenario involving with and without common-envelope phase (i.e., CE channel and stable mass transfer channel), or alternatively of massive close binaries evolving chemically homogeneously (i.e., CHE channel). We perform detailed stellar structure and binary evolution calculations that take into account internal differential rotation and mass loss of He-rich stars, as well as tidal interactions in binaries. For double He-rich stars with equal masses in binaries, we find that tides start to be at work on the Zero Age Helium Main Sequence (ZAHeMS: the time when a He-rich star starts to burn helium in the core, which is analogous to ZAMS for core hydrogen burning) for initial orbital periods not longer than 1.0 day, depending on the initial metallicities. Besides the stellar mass loss rate and tidal interactions in binaries, we find that the role of the angular momentum transport efficiency in determining the resulting BH spins, becomes stronger when considering BH progenitors originated from a higher metal-metallicity environment. We highlight that double-core evolution scenario does not always produce fast-spinning BBHs and compare the properties of the BBHs reported from the LVK with our modeling., Comment: 16 pages, 14 figures, accepted in A&A
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- 2023
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78. Direct experimental evidence of tunable charge transfer at the LaNiO3/CaMnO3 ferromagnetic interface
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Paudel, JR, Terilli, M, Wu, T-C, Grassi, JD, Derrico, AM, Sah, RK, Kareev, M, Wen, F, Klewe, C, Shafer, P, Gloskovskii, A, Schlueter, C, Strocov, VN, Chakhalian, J, and Gray, AX
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Engineering ,Physical Sciences ,Condensed Matter Physics ,Chemical sciences ,Physical sciences - Abstract
Interfacial charge transfer in oxide heterostructures gives rise to a rich variety of electronic and magnetic phenomena. Designing heterostructures where one of the thin-film components exhibits a metal-insulator transition opens a promising avenue for controlling such phenomena both statically and dynamically. In this work, we utilize a combination of depth-resolved soft x-ray standing-wave and hard x-ray photoelectron spectroscopies in conjunction with polarization-dependent x-ray absorption spectroscopy to investigate the effects of the metal-insulator transition in LaNiO3 on the electronic and magnetic states at the LaNiO3/CaMnO3 interface. We report a direct observation of the reduced effective valence state of the interfacial Mn cations in the metallic superlattice with an above-critical LaNiO3 thickness (6 unit cells, u.c.) facilitated by the charge transfer of itinerant Ni3deg electrons into the interfacial CaMnO3 layer. Conversely, in an insulating superlattice with a below-critical LaNiO3 thickness of 2u.c., a homogeneous effective valence state of Mn is observed throughout the CaMnO3 layers due to the blockage of charge transfer across the interface. The ability to switch and tune interfacial charge transfer enables precise control of the emergent ferromagnetic state at the LaNiO3/CaMnO3 interface and, thus, has far-reaching consequences on the future strategies for the design of next-generation spintronic devices.
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- 2023
79. A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue.
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Zhao, Liming, Lee, Andrew S, Sasagawa, Koki, Sokol, Jan, Wang, Yuting, Ransom, Ryan C, Zhao, Xin, Ma, Chao, Steininger, Holly M, Koepke, Lauren S, Borrelli, Mimi R, Brewer, Rachel E, Lee, Lorene LY, Huang, Xianxi, Ambrosi, Thomas H, Sinha, Rahul, Hoover, Malachia Y, Seita, Jun, Weissman, Irving L, Wu, Joseph C, Wan, Derrick C, Xiao, Jun, Longaker, Michael T, Nguyen, Patricia K, and Chan, Charles KF
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Adipose Tissue ,Mesenchymal Stem Cells ,Hindlimb ,Animals ,Humans ,Mice ,Ischemia ,Disease Models ,Animal ,Neovascularization ,Pathologic ,Neovascularization ,Physiologic ,adipose tissue ,angiogenesis ,hindlimb ischemia ,mesenchymal stem cells ,neovascularization ,peripheral vascular disease ,stem cells ,Regenerative Medicine ,Stem Cell Research - Nonembryonic - Non-Human ,Stem Cell Research ,Biotechnology ,Transplantation ,2.1 Biological and endogenous factors ,Aetiology ,Cardiovascular ,Good Health and Well Being ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
BackgroundPeripheral vascular disease remains a leading cause of vascular morbidity and mortality worldwide despite advances in medical and surgical therapy. Besides traditional approaches, which can only restore blood flow to native arteries, an alternative approach is to enhance the growth of new vessels, thereby facilitating the physiological response to ischemia.MethodsThe ActinCreER/R26VT2/GK3 Rainbow reporter mouse was used for unbiased in vivo survey of injury-responsive vasculogenic clonal formation. Prospective isolation and transplantation were used to determine vessel-forming capacity of different populations. Single-cell RNA-sequencing was used to characterize distinct vessel-forming populations and their interactions.ResultsTwo populations of distinct vascular stem/progenitor cells (VSPCs) were identified from adipose-derived mesenchymal stromal cells: VSPC1 is CD45-Ter119-Tie2+PDGFRa-CD31+CD105highSca1low, which gives rise to stunted vessels (incomplete tubular structures) in a transplant setting, and VSPC2 which is CD45-Ter119-Tie2+PDGFRa+CD31-CD105lowSca1high and forms stunted vessels and fat. Interestingly, cotransplantation of VSPC1 and VSPC2 is required to form functional vessels that improve perfusion in the mouse hindlimb ischemia model. Similarly, VSPC1 and VSPC2 populations isolated from human adipose tissue could rescue the ischemic condition in mice.ConclusionsThese findings suggest that autologous cotransplantation of synergistic VSPCs from nonessential adipose tissue can promote neovascularization and represents a promising treatment for ischemic disease.
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- 2023
80. Protocol to generate cardiac pericytes from human induced pluripotent stem cells
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Shen, Mengcheng, Zhao, Shane Rui, Khokhar, Yaser, Li, Li, Zhou, Yang, Liu, Chun, and Wu, Joseph C
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Medical Biotechnology ,Biomedical and Clinical Sciences ,Stem Cell Research ,Stem Cell Research - Induced Pluripotent Stem Cell - Human ,Stem Cell Research - Induced Pluripotent Stem Cell ,Regenerative Medicine ,Cardiovascular ,Heart Disease ,1.1 Normal biological development and functioning ,Cell Differentiation ,Developmental Biology ,Stem Cells - Abstract
Cardiac pericytes are a critical yet enigmatic cell type within the coronary microvasculature. Since primary human cardiac pericytes are not readily accessible, we present a protocol to generate them from human induced pluripotent stem cells (hiPSCs). Our protocol involves several steps, including the generation of intermediate cell types such as mid-primitive streak, lateral plate mesoderm, splanchnic mesoderm, septum transversum, and epicardium, before deriving cardiac pericytes. With hiPSC-derived cardiac pericytes, researchers can decipher the mechanisms underlying coronary microvascular dysfunction. For complete details on the use and execution of this protocol, please refer to Shen et al.1.
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- 2023
81. Ultrahigh‐Capacity Rocksalt Cathodes Enabled by Cycling‐Activated Structural Changes
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Ahn, Juhyeon, Giovine, Raynald, Wu, Vincent C, Koirala, Krishna Prasad, Wang, Chongmin, Clément, Raphaële J, and Chen, Guoying
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Engineering ,Materials Engineering ,Chemical Sciences ,Physical Chemistry ,Affordable and Clean Energy ,capacity rise with cycling ,disordered rocksalts ,lithium-ion batteries ,Mn-rich cathode materials ,structural transformation ,Macromolecular and Materials Chemistry ,Interdisciplinary Engineering ,Macromolecular and materials chemistry ,Materials engineering - Abstract
Mn-redox-based oxides and oxyfluorides are considered the most promising earth-abundant high-energy cathode materials for next-generation lithium-ion batteries. While high capacities are obtained in high-Mn content cathodes such as Li- and Mn-rich layered and spinel-type materials, local structure changes and structural distortions (often lead to voltage fade, capacity decay, and impedance rise, resulting in unacceptable electrochemical performance upon cycling. In the present study, structural transformations that exploit the high capacity of Mn-rich oxyfluorides while enabling stable cycling, in stark contrast to commonly observed structural changes that result in rapid performance degradation, are reported. It is shown that upon cycling of a cation-disordered rocksalt (DRX) cathode (Li1.1Mn0.8Ti0.1O1.9F0.1, an ultrahigh capacity of ≈320 mAh g−1 (energy density of ≈900 Wh kg−1) can be obtained through dynamic structural rearrangements upon cycling, along with a unique voltage profile evolution and capacity rise. At high voltage, the presence of Mn4+ and Li+ vacancies promotes local cation ordering, leading to the formation of domains of a “δ phase” within the disordered framework. On deep discharge, Mn4+ reduction, along with Li+ insertion transform the structure to a partially ordered DRX phase with a β′-LiFeO2-type arrangement. At the nanoscale, domains of the in situ formed phases are randomly oriented, allowing highly reversible structural changes and stable electrochemical cycling. These new insights not only help explain the superior electrochemical performance of high-Mn DRXbut also provide guidance for the future development of Mn-based, high-energy density oxide, and oxyfluoride cathode materials.
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- 2023
82. Two-dimensional THz spectroscopy of nonlinear phononics in the topological insulator $\mathrm{MnBi}_2\mathrm{Te}_4$
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Blank, T. G. H., Grishunin, K. A., Zvezdin, K. A., Hai, N. T., Wu, J. C., Su, S. -H., Huang, J. -C. A., Zvezdin, A. K., and Kimel, A. V.
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Condensed Matter - Materials Science - Abstract
The interaction of a single-cycle THz electric field with the topological insulator $\mathrm{MnBi}_2\mathrm{Te}_4$ triggers strongly anharmonic lattice dynamics, promoting fully coherent energy transfer between the otherwise non-interacting Raman-active $E_g$ and infrared (IR)-active $E_u$ phononic modes. Two-dimensional (2D) THz spectroscopy combined with modeling based on the classical equations of motion and symmetry analysis reveals the multi-stage process underlying the excitation of the Raman-active $E_g$ phonon. In this process, the THz electric field first prepares a coherent IR-active $E_u$ phononic state and subsequently interacts with this state to efficiently excite the $E_g$ phonon., Comment: 27 pages, 20 figures
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- 2022
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83. Screening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging
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Wang, Yan-Ran (Joyce), Yang, Kai, Wen, Yi, Wang, Pengcheng, Hu, Yuepeng, Lai, Yongfan, Wang, Yufeng, Zhao, Kankan, Tang, Siyi, Zhang, Angela, Zhan, Huayi, Lu, Minjie, Chen, Xiuyu, Yang, Shujuan, Dong, Zhixiang, Wang, Yining, Liu, Hui, Zhao, Lei, Huang, Lu, Li, Yunling, Wu, Lianming, Chen, Zixian, Luo, Yi, Liu, Dongbo, Zhao, Pengbo, Lin, Keldon, Wu, Joseph C., and Zhao, Shihua
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- 2024
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84. Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century: “What Are the Tools Needed for the Job?” and “Do We Have Them?”
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Chandy, Mark, Hill, III, Thomas, Jimenez-Tellez, Nerea, Wu, Joseph C., Sarles, S. Emma, Hensel, Edward, Wang, Qixin, Rahman, Irfan, and Conklin, Daniel J.
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- 2024
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85. Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction
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Tu, Chengyi, Caudal, Arianne, Liu, Yu, Gorgodze, Nikoloz, Zhang, Hao, Lam, Chi Keung, Dai, Yuqin, Zhang, Angela, Wnorowski, Alexa, Wu, Matthew A., Yang, Huaxiao, Abilez, Oscar J., Lyu, Xuchao, Narayan, Sanjiv M., Mestroni, Luisa, Taylor, Matthew R. G., Recchia, Fabio A., and Wu, Joseph C.
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- 2024
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86. Successful treatment of medically and surgically refractory lymphocytic hypophysitis with fractionated stereotactic radiotherapy: a single-center experience and systematic literature review
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Khaleghi, Mehdi, Finger, Guilherme, Wu, Kyle C., Munjal, Vikas, Ghalib, Luma, Kobalka, Peter, Blakaj, Dukagjin, Dibs, Khaled, Carrau, Ricardo, and Prevedello, Daniel
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- 2024
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87. Hyponatremia, hypernatremia and impairment of functional, psychological and sexual domains
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Norello, D., Rastrelli, G., Antonio, L., Bartfai, G., Casanueva, F. F., Giwercman, A., Huhtaniemi, I. T., O’Neill, T. W., Punab, M., Slowikowska-Hilczer, J., Tournoy, J., Vanderschueren, D., Wu, F. C. W., Maggi, M., and Peri, A.
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- 2024
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88. Classification of Free-Living Body Posture with ECG Patch Accelerometers: Application to the Multicenter AIDS Cohort Study
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Etzkorn, Lacey H., Heravi, Amir S., Knuth, Nicolas D., Wu, Katherine C., Post, Wendy S., Urbanek, Jacek K., and Crainiceanu, Ciprian M.
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- 2024
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89. Reductions in smoking due to ratification of the Framework Convention for Tobacco Control in 171 countries
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Paraje, Guillermo, Flores Muñoz, Mauricio, Wu, Daphne C., and Jha, Prabhat
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- 2024
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90. Search for boosted keV-MeV light dark matter particles from evaporating primordial black holes at the CDEX-10 experiment
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Zhang, Z. H., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Karmakar, S., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, J. X., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Instrumentation and Detectors - Abstract
We present novel constraints on boosted light dark matter particles (denoted as ``$\chi$'') from evaporating primordial black holes (PBHs) using 205.4 kg$\cdot$day data from the China Jinping Underground Laboratory's CDEX-10 p-type point contact germanium detector with a 160 eVee analysis threshold. $\chi$ from PBHs with masses ranging from 1$\times$10$^{15}$ g to 7$\times$10$^{16}$ g are searched in this work. In the presence of PBH abundance compatible with present bounds, our result excludes the $\chi$-nucleon elastic-scattering cross section region from 3.4$\times$10$^{-32}$ cm$^{2}$ to 2.3$\times$10$^{-29}$ cm$^{2}$ for $\chi$ of 1 keV to 24 MeV from PBHs with masses of 5$\times$10$^{15}$ g, as well as from 1.1$\times$10$^{-28}$ cm$^{2}$ to 7.6$\times$10$^{-28}$ cm$^{2}$ for $\chi$ of 1 keV to 0.6 MeV from PBHs with masses of 7$\times$10$^{16}$ g. If the $\chi$-nucleon elastic-scattering cross section can be determined in the future, the abundance of PBHs may be severely constrained by $\chi$ evaporation. With the lower threshold (160 eVee) of the CDEX-10 experiment compared to the previously used experiments, this work allows for a better reach at soft spectra produced by heavier PBHs, which demonstrates the vast potential of such a technical route to pursue $\chi$ from larger PBHs with a low threshold., Comment: 8 pages, 6 figures. Version updated to match PRD version
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- 2022
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91. Search for exotic interactions of solar neutrinos in the CDEX-10 experiment
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Geng, X. P., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Karmakar, S., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, J. X., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Instrumentation and Detectors - Abstract
We investigate exotic neutrino interactions using the 205.4 kg$\cdot$day dataset from the CDEX-10 experiment at the China Jinping Underground Laboratory. New constraints on the mass and couplings of new gauge bosons are presented. Two nonstandard neutrino interactions are considered: a $U(1)_{B-L}$ gauge-boson-induced interaction between an active neutrino and electron/nucleus, and a dark-photon-induced interaction between a sterile neutrino and electron/nucleus via kinetic mixing with a photon. This work probes an unexplored parameter space involving sterile neutrino coupling with a dark photon. New laboratory limits are derived on dark photon masses below $1~{\rm eV}/c^{2}$ at some benchmark values of $\Delta m_{41}^{2}$ and $g^{\prime2}{\rm{sin}}^{2}2\theta_{14}$., Comment: 6 pages, 4 figures. Version updated to match PRD version
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- 2022
- Full Text
- View/download PDF
92. Center Feature Fusion: Selective Multi-Sensor Fusion of Center-based Objects
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Jacobson, Philip, Zhou, Yiyang, Zhan, Wei, Tomizuka, Masayoshi, and Wu, Ming C.
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Leveraging multi-modal fusion, especially between camera and LiDAR, has become essential for building accurate and robust 3D object detection systems for autonomous vehicles. Until recently, point decorating approaches, in which point clouds are augmented with camera features, have been the dominant approach in the field. However, these approaches fail to utilize the higher resolution images from cameras. Recent works projecting camera features to the bird's-eye-view (BEV) space for fusion have also been proposed, however they require projecting millions of pixels, most of which only contain background information. In this work, we propose a novel approach Center Feature Fusion (CFF), in which we leverage center-based detection networks in both the camera and LiDAR streams to identify relevant object locations. We then use the center-based detection to identify the locations of pixel features relevant to object locations, a small fraction of the total number in the image. These are then projected and fused in the BEV frame. On the nuScenes dataset, we outperform the LiDAR-only baseline by 4.9% mAP while fusing up to 100x fewer features than other fusion methods., Comment: Accepted by ICRA 2023
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- 2022
93. Exotic Dark Matter Search with CDEX-10 Experiment at China's Jinping Underground Laboratory
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Dai, W. H., Jia, L. P., Ma, H., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Karmakar, S., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yang, L. T., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
A search for exotic dark matter (DM) in the sub-GeV mass range has been conducted using 205 kg$\cdot$day data taken from a p-type point contact germanium detector of CDEX-10 experiment at China Jinping underground laboratory. New low-mass dark matter searching channels, neutral current fermionic DM absorption ($\chi+A\rightarrow \nu+A$) and DM-nucleus 3$\rightarrow$2 scattering ($\chi+\chi+A\rightarrow \phi+A$), have been analyzed with an energy threshold of 160 eVee. No significant signal was found. Thus new limits on the DM-nucleon interaction cross section are set for both models at sub-GeV DM mass region. A cross section limit for the fermionic DM absorption is set to be $\rm 2.5\times 10^{-46} cm^2$(90\% C.L.) at DM mass of 10 MeV/c$^2$. For the DM-nucleus 3$\rightarrow$2 scattering scenario, limits are extended to DM mass of 5 MeV/c$^2$ and 14 MeV/c$^2$ for the massless dark photon and bound DM final state, respectively., Comment: 5 pages, 7 figures
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- 2022
- Full Text
- View/download PDF
94. Polymorphism in Weberite Na2Fe2F7 and its Effects on Electrochemical Properties as a Na-Ion Cathode
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Foley, Emily E, Wu, Vincent C, Jin, Wen, Cui, Wei, Yoshida, Eric, Manche, Alexis, and Clément, Raphaële J
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Engineering ,Materials Engineering ,Chemical Sciences ,Physical Chemistry ,Affordable and Clean Energy ,Materials ,Chemical sciences - Abstract
Weberite-type sodium transition metal fluorides (Na2M2+M'3+F7) have emerged as potential high-performance sodium intercalation cathodes, with predicted energy densities in the 600-800 W h/kg range and fast Na-ion transport. One of the few weberites that have been electrochemically tested is Na2Fe2F7, yet inconsistencies in its reported structure and electrochemical properties have hampered the establishment of clear structure-property relationships. In this study, we reconcile structural characteristics and electrochemical behavior using a combined experimental-computational approach. First-principles calculations reveal the inherent metastability of weberite-type phases, the close energetics of several Na2Fe2F7 weberite polymorphs, and their predicted (de)intercalation behavior. We find that the as-prepared Na2Fe2F7 samples inevitably contain a mixture of polymorphs, with local probes such as solid-state nuclear magnetic resonance (NMR) and Mössbauer spectroscopy providing unique insights into the distribution of Na and Fe local environments. Polymorphic Na2Fe2F7 exhibits a respectable initial capacity yet steady capacity fade, a consequence of the transformation of the Na2Fe2F7 weberite phases to the more stable perovskite-type NaFeF3 phase upon cycling, as revealed by ex situ synchrotron X-ray diffraction and solid-state NMR. Overall, these findings highlight the need for greater control over weberite polymorphism and phase stability through compositional tuning and synthesis optimization.
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- 2023
95. Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging
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Liu, Ling, Kim, Soochi, Buckley, Matthew T, Reyes, Jaime M, Kang, Jengmin, Tian, Lei, Wang, Mingqiang, Lieu, Alexander, Mao, Michelle, Rodriguez-Mateo, Cristina, Ishak, Heather D, Jeong, Mira, Wu, Joseph C, Goodell, Margaret A, Brunet, Anne, and Rando, Thomas A
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Medical Biotechnology ,Biomedical and Clinical Sciences ,Stem Cell Research - Nonembryonic - Non-Human ,Regenerative Medicine ,Physical Activity ,Stem Cell Research ,Aging ,Stem Cell Research - Nonembryonic - Human ,Genetics ,1.1 Normal biological development and functioning ,Inflammatory and immune system ,Mice ,Animals ,Hematopoietic Stem Cells ,Physical Conditioning ,Animal ,Transcriptome ,Gene Expression Profiling ,Muscle ,Skeletal ,Stem Cell Niche ,Mammals ,aging ,exercise ,hematopoietic stem cells ,inflammation ,muscle stem cells ,myofibers ,neural stem cells ,scRNA-seq ,skeletal muscle ,subventricular zone ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
Exercise has the ability to rejuvenate stem cells and improve tissue regeneration in aging animals. However, the cellular and molecular changes elicited by exercise have not been systematically studied across a broad range of cell types in stem cell compartments. We subjected young and old mice to aerobic exercise and generated a single-cell transcriptomic atlas of muscle, neural, and hematopoietic stem cells with their niche cells and progeny, complemented by whole transcriptome analysis of single myofibers. We found that exercise ameliorated the upregulation of a number of inflammatory pathways associated with old age and restored aspects of intercellular communication mediated by immune cells within these stem cell compartments. Exercise has a profound impact on the composition and transcriptomic landscape of circulating and tissue-resident immune cells. Our study provides a comprehensive view of the coordinated responses of multiple aged stem cells and niche cells to exercise at the transcriptomic level.
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- 2023
96. Statins improve endothelial function via suppression of epigenetic-driven EndMT
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Liu, Chun, Shen, Mengcheng, Tan, Wilson LW, Chen, Ian Y, Liu, Yu, Yu, Xuan, Yang, Huaxiao, Zhang, Angela, Liu, Yanxia, Zhao, Ming-Tao, Ameen, Mohamed, Zhang, Mao, Gross, Eric R, Qi, Lei S, Sayed, Nazish, and Wu, Joseph C
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Stem Cell Research ,Diabetes ,Stem Cell Research - Induced Pluripotent Stem Cell ,Genetics ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,Cardiovascular - Abstract
The pleiotropic benefits of statins in cardiovascular diseases that are independent of their lipid-lowering effects have been well documented, but the underlying mechanisms remain elusive. Here we show that simvastatin significantly improves human induced pluripotent stem cell-derived endothelial cell functions in both baseline and diabetic conditions by reducing chromatin accessibility at transcriptional enhanced associate domain elements and ultimately at endothelial-to-mesenchymal transition (EndMT)-regulating genes in a yes-associated protein (YAP)-dependent manner. Inhibition of geranylgeranyltransferase (GGTase) I, a mevalonate pathway intermediate, repressed YAP nuclear translocation and YAP activity via RhoA signaling antagonism. We further identified a previously undescribed SOX9 enhancer downstream of statin-YAP signaling that promotes the EndMT process. Thus, inhibition of any component of the GGTase-RhoA-YAP-SRY box transcription factor 9 (SOX9) signaling axis was shown to rescue EndMT-associated endothelial dysfunction both in vitro and in vivo, especially under diabetic conditions. Overall, our study reveals an epigenetic modulatory role for simvastatin in repressing EndMT to confer protection against endothelial dysfunction.
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- 2023
97. Identifying predictors of on-table adaptation for pancreas stereotactic body radiotherapy (SBRT)
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Wu, Trudy C, Yoon, Stephanie M, Cao, Minsong, Raldow, Ann C, and Xiang, Michael
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Digestive Diseases ,Cancer ,6.5 Radiotherapy and other non-invasive therapies ,Evaluation of treatments and therapeutic interventions ,Pancreatic cancer ,Stereotactic body radiation therapy ,Adaptive planning ,MRI-guided radiotherapy ,Oncology and carcinogenesis - Abstract
PurposeTo identify any clinical or dosimetric parameters that predict which individuals may benefit from on-table adaptation during pancreas stereotactic body radiotherapy (SBRT) with MRI-guided radiotherapy.Methods and materialsThis was a retrospective study of patients undergoing MRI-guided SBRT from 2016 to 2022. Pre-treatment clinical variables and dosimetric parameters on the patient's simulation scan were recorded for each SBRT course, and their ability to predict for on-table adaptation was analyzed using ordinal logistic regression. The outcome measure was number of fractions adapted.ResultsSixty-three SBRT courses consisting of 315 fractions were analyzed. Median prescription dose was 40 Gy in five fractions (range, 33-50 Gy); 52% and 48% of courses were prescribed ≤40 Gy and >40 Gy, respectively. The median minimum dose delivered to 95% (D95) of the gross tumor volume (GTV) and planning target volume (PTV) was 40.1 Gy and 37.0 Gy, respectively. Median number of fractions adapted per course was three, with 58% (183 out of 315) total fractions adapted. On univariable analysis, the prescription dose (>40 Gy vs ≤40 Gy), GTV volume, stomach V20 and V25, duodenum V20 and dose maximum, large bowel V33 and V35, GTV dose minimum, PTV dose minimum, and gradient index were significant determinants for adaptation (all p
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- 2023
98. Tuning Bulk Redox and Altering Interfacial Reactivity in Highly Fluorinated Cation-Disordered Rocksalt Cathodes
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Crafton, Matthew J, Huang, Tzu-Yang, Yue, Yuan, Giovine, Raynald, Wu, Vincent C, Dun, Chaochao, Urban, Jeffrey J, Clément, Raphaële J, Tong, Wei, and McCloskey, Bryan D
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Engineering ,Materials Engineering ,Chemical Sciences ,Physical Chemistry ,Affordable and Clean Energy ,cation-disordered rocksalt ,differential electrochemical mass spectrometry ,titration mass spectrometry ,cathode-electrolyte interface ,electrolyte degradation ,oxygen redox ,high voltage ,fluoride-scavenging ,cathode−electrolyte interface ,Nanoscience & Nanotechnology ,Chemical sciences ,Physical sciences - Abstract
Lithium-excess, cation-disordered rocksalt (DRX) materials have been subject to intense scrutiny and development in recent years as potential cathode materials for Li-ion batteries. Despite their compositional flexibility and high initial capacity, they suffer from poorly understood parasitic degradation reactions at the cathode-electrolyte interface. These interfacial degradation reactions deteriorate both the DRX material and electrolyte, ultimately leading to capacity fade and voltage hysteresis during cycling. In this work, differential electrochemical mass spectrometry (DEMS) and titration mass spectrometry are combined to quantify the extent of bulk redox and surface degradation reactions for a set of Mn2+/4+-based DRX oxyfluorides during initial cycling with a high-voltage charging cutoff (4.8 V vs Li/Li+). Increasing the fluorine content from 7.5 to 33.75% is shown to diminish oxygen redox and suppresses high-voltage O2 evolution from the DRX surface. Additionally, electrolyte degradation processes resulting in the formation of both gaseous species and electrolyte-soluble protic species are observed. Subsequently, DEMS is paired with a fluoride-scavenging additive to demonstrate that increasing fluorine content leads to increased dissolution of fluorine from the DRX material into the electrolyte. Finally, a suite of ex situ spectroscopy techniques (X-ray photoelectron spectroscopy, inductively coupled plasma optical emission spectroscopy, and solid-state nuclear magnetic resonance spectroscopy) are employed to study the change in DRX composition during charging, revealing the dissolution of manganese and fluorine from the DRX material at high voltages. This work provides insight into the degradation processes occurring at the DRX-electrolyte interface and points toward potential routes of interfacial stabilization.
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- 2023
99. Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma
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Patel, Sapna P, Othus, Megan, Chen, Yuanbin, Wright, G Paul, Yost, Kathleen J, Hyngstrom, John R, Hu-Lieskovan, Siwen, Lao, Christopher D, Fecher, Leslie A, Truong, Thach-Giao, Eisenstein, Jennifer L, Chandra, Sunandana, Sosman, Jeffrey A, Kendra, Kari L, Wu, Richard C, Devoe, Craig E, Deutsch, Gary B, Hegde, Aparna, Khalil, Maya, Mangla, Ankit, Reese, Amy M, Ross, Merrick I, Poklepovic, Andrew S, Phan, Giao Q, Onitilo, Adedayo A, Yasar, Demet G, Powers, Benjamin C, Doolittle, Gary C, In, Gino K, Kokot, Niels, Gibney, Geoffrey T, Atkins, Michael B, Shaheen, Montaser, Warneke, James A, Ikeguchi, Alexandra, Najera, Jose E, Chmielowski, Bartosz, Crompton, Joseph G, Floyd, Justin D, Hsueh, Eddy, Margolin, Kim A, Chow, Warren A, Grossmann, Kenneth F, Dietrich, Eliana, Prieto, Victor G, Lowe, Michael C, Buchbinder, Elizabeth I, Kirkwood, John M, Korde, Larissa, Moon, James, Sharon, Elad, Sondak, Vernon K, and Ribas, Antoni
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Trials and Supportive Activities ,Patient Safety ,Cancer ,Clinical Research ,6.1 Pharmaceuticals ,6.4 Surgery ,Humans ,Adjuvants ,Immunologic ,Disease Progression ,Melanoma ,Neoadjuvant Therapy ,Skin Neoplasms ,Antineoplastic Agents ,Immunological ,Chemotherapy ,Adjuvant ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundWhether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable stage III or IV melanoma is unknown.MethodsIn a phase 2 trial, we randomly assigned patients with clinically detectable, measurable stage IIIB to IVC melanoma that was amenable to surgical resection to three doses of neoadjuvant pembrolizumab, surgery, and 15 doses of adjuvant pembrolizumab (neoadjuvant-adjuvant group) or to surgery followed by pembrolizumab (200 mg intravenously every 3 weeks for a total of 18 doses) for approximately 1 year or until disease recurred or unacceptable toxic effects developed (adjuvant-only group). The primary end point was event-free survival in the intention-to-treat population. Events were defined as disease progression or toxic effects that precluded surgery; the inability to resect all gross disease; disease progression, surgical complications, or toxic effects of treatment that precluded the initiation of adjuvant therapy within 84 days after surgery; recurrence of melanoma after surgery; or death from any cause. Safety was also evaluated.ResultsAt a median follow-up of 14.7 months, the neoadjuvant-adjuvant group (154 patients) had significantly longer event-free survival than the adjuvant-only group (159 patients) (P = 0.004 by the log-rank test). In a landmark analysis, event-free survival at 2 years was 72% (95% confidence interval [CI], 64 to 80) in the neoadjuvant-adjuvant group and 49% (95% CI, 41 to 59) in the adjuvant-only group. The percentage of patients with treatment-related adverse events of grades 3 or higher during therapy was 12% in the neoadjuvant-adjuvant group and 14% in the adjuvant-only group.ConclusionsAmong patients with resectable stage III or IV melanoma, event-free survival was significantly longer among those who received pembrolizumab both before and after surgery than among those who received adjuvant pembrolizumab alone. No new toxic effects were identified. (Funded by the National Cancer Institute and Merck Sharp and Dohme; S1801 ClinicalTrials.gov number, NCT03698019.).
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- 2023
100. Rapid and Energy‐Efficient Synthesis of Disordered Rocksalt Cathodes
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Wu, Vincent C, Evans, Hayden A, Giovine, Raynald, Preefer, Molleigh B, Ong, Julia, Yoshida, Eric, Cabelguen, Pierre‐Etienne, and Clément, Raphaële J
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Engineering ,Materials Engineering ,Chemical Sciences ,Physical Chemistry ,Affordable and Clean Energy ,cations ,disordered rocksalts ,lithium-ion batteries ,microwave synthesis ,Macromolecular and Materials Chemistry ,Interdisciplinary Engineering ,Macromolecular and materials chemistry ,Materials engineering - Abstract
Abstract: Lithium‐rich transition metal oxides with a cation‐disordered rocksalt structure (disordered rocksalt oxides or DRX) are promising candidates for sustainable, next‐generation Li‐ion cathodes due to their high energy densities and compositional flexibility, enabling Co‐ and Ni‐free battery chemistries. However, current methods to synthesize DRX compounds require either high temperature (≈1000 °C) sintering for several hours, or high energy ball milling for several days in an inert atmosphere. Both methods are time‐ and energy‐intensive, limiting the scale up of DRX production. The present study reports the rapid synthesis of various DRX compositions in ambient air via a microwave‐assisted solid‐state technique resulting in reaction times as short as 5 min, which are more than two orders of magnitude faster than current synthesis methods. The DRX compounds synthesized via microwave are phase‐pure and have a similar short‐ and long‐range structure as compared to DRX materials synthesized via a standard solid‐state route, resulting in nearly identical electrochemical performance. In some cases, microwave heating allows for better particle size and morphology control. Overall, the rapid and energy‐efficient microwave technique provides a more sustainable route to produce DRX materials, further incentivizes the development of next‐generation DRX cathodes, and is key to accelerating their optimization via high‐throughput studies.
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- 2023
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