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577 results on '"WANG Chenfei"'

55. A single-cell and spatially resolved atlas of human breast cancers

Author

Wu, Sunny Z., Al-Eryani, Ghamdan, Roden, Daniel Lee, Junankar, Simon, Harvey, Kate, Andersson, Alma, Thennavan, Aatish, Wang, Chenfei, Torpy, James R., Bartonicek, Nenad, Wang, Taopeng, Larsson, Ludvig, Kaczorowski, Dominik, Weisenfeld, Neil I., Uytingco, Cedric R., Chew, Jennifer G., Bent, Zachary W., Chan, Chia-Ling, Gnanasambandapillai, Vikkitharan, Dutertre, Charles-Antoine, Gluch, Laurence, Hui, Mun N., Beith, Jane, Parker, Andrew, Robbins, Elizabeth, Segara, Davendra, Cooper, Caroline, Mak, Cindy, Chan, Belinda, Warrier, Sanjay, Ginhoux, Florent, Millar, Ewan, Powell, Joseph E., Williams, Stephen R., Liu, X. Shirley, O’Toole, Sandra, Lim, Elgene, Lundeberg, Joakim, Perou, Charles M., and Swarbrick, Alexander

Published
2021
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57. Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials

Author

Yang, Shilong, Li, Yan, Dai, Lianpan, Wang, Jianfeng, He, Peng, Li, Changgui, Fang, Xin, Wang, Chenfei, Zhao, Xiang, Huang, Enqi, Wu, Changwei, Zhong, Zaixin, Wang, Fengze, Duan, Xiaomin, Tian, Siyu, Wu, Lili, Liu, Yan, Luo, Yi, Chen, Zhihai, Li, Fangjun, Li, Junhua, Yu, Xian, Ren, Hong, Liu, Lihong, Meng, Shufang, Yan, Jinghua, Hu, Zhongyu, Gao, Lidong, and Gao, George F

Published
2021
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58. Single-cell and spatial multiomic inference of gene regulatory networks using SCRIPro.

Author

Chang, Zhanhe, Xu, Yunfan, Dong, Xin, Gao, Yawei, and Wang, Chenfei

Subjects
GENETIC regulation, HAIR follicles, MULTIOMICS, CHROMATIN, MICE
Abstract

Motivation The burgeoning generation of single-cell or spatial multiomic data allows for the characterization of gene regulation networks (GRNs) at an unprecedented resolution. However, the accurate reconstruction of GRNs from sparse and noisy single-cell or spatial multiomic data remains challenging. Results Here, we present SCRIPro, a comprehensive computational framework that robustly infers GRNs for both single-cell and spatial multiomics data. SCRIPro first improves sample coverage through a density clustering approach based on multiomic and spatial similarities. Additionally, SCRIPro scans transcriptional regulator (TR) importance by performing chromatin reconstruction and in silico deletion analyses using a comprehensive reference covering 1292 human and 994 mouse TRs. Finally, SCRIPro combines TR-target importance scores derived from multiomic data with TR-target expression levels to ensure precise GRN reconstruction. We benchmarked SCRIPro on various datasets, including single-cell multiomic data from human B-cell lymphoma, mouse hair follicle development, Stereo-seq of mouse embryos, and Spatial-ATAC-RNA from mouse brain. SCRIPro outperforms existing motif-based methods and accurately reconstructs cell type-specific, stage-specific, and region-specific GRNs. Overall, SCRIPro emerges as a streamlined and fast method capable of reconstructing TR activities and GRNs for both single-cell and spatial multiomic data. Availability and implementation SCRIPro is available at https://github.com/wanglabtongji/SCRIPro. [ABSTRACT FROM AUTHOR]

Published
2024
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64. Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

Author

Burton, Adam, Brochard, Vincent, Galan, Carmen, Ruiz-Morales, Elias R., Rovira, Quirze, Rodriguez-Terrones, Diego, Kruse, Kai, Le Gras, Stéphanie, Udayakumar, Vishnu S., Chin, Hang Gyeong, Eid, André, Liu, Xiaoyu, Wang, Chenfei, Gao, Shaorong, Pradhan, Sriharsa, Vaquerizas, Juan M., Beaujean, Nathalie, Jenuwein, Thomas, and Torres-Padilla, Maria-Elena

Published
2020
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66. Transplantation of the LRP1high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice.

Author

Shen, Jiacheng, Wu, Li, Shi, Xiaoying, Chen, Gang, Liu, Tingwei, Xu, Fangfang, Xu, Xiaocui, Kou, Xiaochen, Zhao, Yanhong, Wang, Hong, Wang, Chenfei, Gao, Shaorong, and Xu, Shaohua

Subjects
PREMATURE ovarian failure, MESENCHYMAL stem cells, TISSUE remodeling, GRANULOSA cells, OVARIAN follicle, EXTRACELLULAR matrix, PROGENITOR cells
Abstract

Background: Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demonstrated unprecedented potential in the treatment of POF. However, the heterogeneity of human UC-MSCs remains a challenge for their large-scale clinical application. Therefore, it is imperative to identify specific subpopulations within UC-MSCs that possess the capability to improve ovarian function, with the aim of reducing the uncertainty arising from the heterogeneity while achieving more effective treatment of POF. Methods: 10 × Genomics was performed to investigate the heterogeneity of human UC-MSCs. We used LRP1 as a marker and distinguished the potential therapeutic subpopulation by flow cytometry, and determined its secretory functions. Unsorted UC-MSCs, LRP1high and LRP1low subpopulation was transplanted under the ovarian capsules of aged mice and CTX-induced POF mice, and therapeutic effects was evaluated by assessing hormone levels, estrous cycles, follicle counts, and embryo numbers. RNA sequencing on mouse oocytes and granulosa cells after transplantation was performed to explore the mechanism of LRP1high subpopulation on mouse oocytes and granulosa cells. Results: We identified three distinct functional subtypes, including mesenchymal stem cells, multilymphoid progenitor cells and trophoblasts. Additionally, we identified the LRP1high subpopulation, which improved ovarian function in aged and POF mice. We elucidated the unique secretory functions of the LRP1high subpopulation, capable of secreting various chemokines, cytokines, and growth factors. Furthermore, LRP1 plays a crucial role in regulating the ovarian microenvironment, including tissue repair and extracellular matrix remodeling. Consistent with its functions, the transcriptomes of oocytes and granulosa cells after transplantation revealed that the LRP1high subpopulation improves ovarian function by modulating the extracellular matrix of oocytes, NAD metabolism, and mitochondrial function in granulosa cells. Conclusion: Through exploration of the heterogeneity of UC-MSCs, we identified the LRP1high subpopulation capable of improving ovarian function in aged and POF mice by secreting various factors and remodeling the extracellular matrix. This study provides new insights into the targeted exploration of human UC-MSCs in the precise treatment of POF. [ABSTRACT FROM AUTHOR]

Published
2024
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77. Clonal tracing reveals diverse patterns of response to immune checkpoint blockade

Author

Gu, Shengqing Stan, Wang, Xiaoqing, Hu, Xihao, Jiang, Peng, Li, Ziyi, Traugh, Nicole, Bu, Xia, Tang, Qin, Wang, Chenfei, Zeng, Zexian, Fu, Jingxin, Meyer, Cliff, Zhang, Yi, Cejas, Paloma, Lim, Klothilda, Wang, Jin, Zhang, Wubing, Tokheim, Collin, Sahu, Avinash Das, Xing, Xiaofang, Kroger, Benjamin, Ouyang, Zhangyi, Long, Henry, Freeman, Gordon J., Brown, Myles, and Liu, X. Shirley

Published
2020
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78. Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer

Author

Wu, Sunny Z, Roden, Daniel L, Wang, Chenfei, Holliday, Holly, Harvey, Kate, Cazet, Aurélie S, Murphy, Kendelle J, Pereira, Brooke, Al‐Eryani, Ghamdan, Bartonicek, Nenad, Hou, Rui, Torpy, James R, Junankar, Simon, Chan, Chia‐Ling, Lam, Chuan En, Hui, Mun N, Gluch, Laurence, Beith, Jane, Parker, Andrew, Robbins, Elizabeth, Segara, Davendra, Mak, Cindy, Cooper, Caroline, Warrier, Sanjay, Forrest, Alistair, Powell, Joseph, O'Toole, Sandra, Cox, Thomas R, Timpson, Paul, Lim, Elgene, Liu, X Shirley, and Swarbrick, Alexander

Published
2020
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82. Figure S12 from Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha

Author

Sahu, Avinash, primary, Wang, Xiaoman, primary, Munson, Phillip, primary, Klomp, Jan P.G., primary, Wang, Xiaoqing, primary, Gu, Shengqing Stan, primary, Han, Ya, primary, Qian, Gege, primary, Nicol, Phillip, primary, Zeng, Zexian, primary, Wang, Chenfei, primary, Tokheim, Collin, primary, Zhang, Wubing, primary, Fu, Jingxin, primary, Wang, Jin, primary, Nair, Nishanth Ulhas, primary, Rens, Joost A.P., primary, Bourajjaj, Meriem, primary, Jansen, Bas, primary, Leenders, Inge, primary, Lemmers, Jaap, primary, Musters, Mark, primary, van Zanten, Sanne, primary, van Zelst, Laura, primary, Worthington, Jenny, primary, Liu, Jun S., primary, Juric, Dejan, primary, Meyer, Clifford A., primary, Oubrie, Arthur, primary, Liu, X. Shirley, primary, Fisher, David E., primary, and Flaherty, Keith T., primary

Published
2023
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83. Data from Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha

Author

Sahu, Avinash, primary, Wang, Xiaoman, primary, Munson, Phillip, primary, Klomp, Jan P.G., primary, Wang, Xiaoqing, primary, Gu, Shengqing Stan, primary, Han, Ya, primary, Qian, Gege, primary, Nicol, Phillip, primary, Zeng, Zexian, primary, Wang, Chenfei, primary, Tokheim, Collin, primary, Zhang, Wubing, primary, Fu, Jingxin, primary, Wang, Jin, primary, Nair, Nishanth Ulhas, primary, Rens, Joost A.P., primary, Bourajjaj, Meriem, primary, Jansen, Bas, primary, Leenders, Inge, primary, Lemmers, Jaap, primary, Musters, Mark, primary, van Zanten, Sanne, primary, van Zelst, Laura, primary, Worthington, Jenny, primary, Liu, Jun S., primary, Juric, Dejan, primary, Meyer, Clifford A., primary, Oubrie, Arthur, primary, Liu, X. Shirley, primary, Fisher, David E., primary, and Flaherty, Keith T., primary

Published
2023
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85. Supplementary tables from Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha

Author

Sahu, Avinash, primary, Wang, Xiaoman, primary, Munson, Phillip, primary, Klomp, Jan P.G., primary, Wang, Xiaoqing, primary, Gu, Shengqing Stan, primary, Han, Ya, primary, Qian, Gege, primary, Nicol, Phillip, primary, Zeng, Zexian, primary, Wang, Chenfei, primary, Tokheim, Collin, primary, Zhang, Wubing, primary, Fu, Jingxin, primary, Wang, Jin, primary, Nair, Nishanth Ulhas, primary, Rens, Joost A.P., primary, Bourajjaj, Meriem, primary, Jansen, Bas, primary, Leenders, Inge, primary, Lemmers, Jaap, primary, Musters, Mark, primary, van Zanten, Sanne, primary, van Zelst, Laura, primary, Worthington, Jenny, primary, Liu, Jun S., primary, Juric, Dejan, primary, Meyer, Clifford A., primary, Oubrie, Arthur, primary, Liu, X. Shirley, primary, Fisher, David E., primary, and Flaherty, Keith T., primary

Published
2023
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86. Supplementary Notes from Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha

Author

Sahu, Avinash, primary, Wang, Xiaoman, primary, Munson, Phillip, primary, Klomp, Jan P.G., primary, Wang, Xiaoqing, primary, Gu, Shengqing Stan, primary, Han, Ya, primary, Qian, Gege, primary, Nicol, Phillip, primary, Zeng, Zexian, primary, Wang, Chenfei, primary, Tokheim, Collin, primary, Zhang, Wubing, primary, Fu, Jingxin, primary, Wang, Jin, primary, Nair, Nishanth Ulhas, primary, Rens, Joost A.P., primary, Bourajjaj, Meriem, primary, Jansen, Bas, primary, Leenders, Inge, primary, Lemmers, Jaap, primary, Musters, Mark, primary, van Zanten, Sanne, primary, van Zelst, Laura, primary, Worthington, Jenny, primary, Liu, Jun S., primary, Juric, Dejan, primary, Meyer, Clifford A., primary, Oubrie, Arthur, primary, Liu, X. Shirley, primary, Fisher, David E., primary, and Flaherty, Keith T., primary

Published
2023
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92. Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha

Author

Sahu, Avinash, primary, Wang, Xiaoman, additional, Munson, Phillip, additional, Klomp, Jan P.G., additional, Wang, Xiaoqing, additional, Gu, Shengqing Stan, additional, Han, Ya, additional, Qian, Gege, additional, Nicol, Phillip, additional, Zeng, Zexian, additional, Wang, Chenfei, additional, Tokheim, Collin, additional, Zhang, Wubing, additional, Fu, Jingxin, additional, Wang, Jin, additional, Nair, Nishanth Ulhas, additional, Rens, Joost A.P., additional, Bourajjaj, Meriem, additional, Jansen, Bas, additional, Leenders, Inge, additional, Lemmers, Jaap, additional, Musters, Mark, additional, van Zanten, Sanne, additional, van Zelst, Laura, additional, Worthington, Jenny, additional, Liu, Jun S., additional, Juric, Dejan, additional, Meyer, Clifford A., additional, Oubrie, Arthur, additional, Liu, X. Shirley, additional, Fisher, David E., additional, and Flaherty, Keith T., additional

Published
2023
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94. Safety, Tolerability, and Immunogenicity of a CpG/Alum Adjuvanted SARS-CoV-2 Recombinant Protein Vaccine (ZR202-CoV) in Healthy Adults: Preliminary Report of a Phase 1, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Trial

Author

Li, Ke, primary, Wang, Zhongfang, additional, He, Peng, additional, Feng, Guang-Wei, additional, Lan, Qin-Ying, additional, Ni, Ling, additional, Yang, Ya-Zheng, additional, Wang, Chenfei, additional, Cui, Ting-Ting, additional, Huang, Lili, additional, Gao, Jin-Tao, additional, Jiang, Zhiwei, additional, Yang, Qing, additional, Yu, Bang-Wei, additional, Han, Xi, additional, Chen, Jing-Jing, additional, Yang, Shu-Yuan, additional, Yuan, Lin, additional, Zhou, Ling-Yun, additional, Huang, Zhen, additional, Xie, Zhiqiang, additional, Zhao, Jincun, additional, Hu, Zhong-Yu, additional, and Li, Ke, additional

Published
2023
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100. Abstract B65: MetaTiME: meta-components of the tumor immune microenvironment

Author

Zhang, Yi, primary, Xiang, Guanjue, additional, Jiang, Yijia Alva, additional, Lynch, Allen, additional, Zeng, Zexian, additional, Wang, Chenfei, additional, Zhang, Wubing, additional, Fan, Jingyu, additional, Kang, Jiajinlong, additional, Gu, Shengqing, additional, Wan, Changxin, additional, Zhang, Boning, additional, Liu, Shirley, additional, Brown, Myles, additional, and Meyer, Clifford, additional

Published
2022
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