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Background: Total parenteral nutrition (TPN) is an invasive and advanced rescue feeding technique that has acceptable short-term survival although at costs of substantial risks. Survival after the clinical use of TPN .6 mo is unknown. Objective: We determined long-term survival after clinical TPN use in a consecutive cohort who were attending an academic hospital. Design: The study included a prospective cohort with a retrospective analysis of all 537 consecutive episodes of TPN in 437 patients between January 2010 and April 2012. Follow-up was until October 2013 with a total follow-up of 608 patient-years. Survival was analyzed by using Kaplan-Meier and Cox regression. Results: Survival was 58% in 437 patients with a first-time use of TPN at an average of 1.5 y after the initiation of TPN. The mortality rate was 30 deaths/100 patient-years. Older age, admission at an intensive care unit or a nonsurgical department, lower body mass index, and an underlying malignancy were positively associated with mortality. Conclusion: TPN use, if correctly indicated, is a clinical sign of intestinal failure and a surrogate marker for markedly increased risk of mortality even .1.5 y after TPN use. This trial was registered at clinicaltrials.gov as NCT02189993 with protocol identification name TPN-01. Am J Clin Nutr doi: 10.3945/ajcn.114.087015.

This article addresses the day-ahead economic optimisation of energy storage systems within the setting of electricity spot markets. The case study is about a lithium-ion battery system integrated in a low voltage distribution grid with residential customers and photovoltaic generation in the Netherlands, whereas the optimisation objective is to maximise revenues from energy arbitrage in the day-ahead auction. Assuming accurate predictions of the photovoltaic generation, the residential load and the market clearing prices, the constrained optimisation problem is formulated as the minimisation of a cost function, and is solved by utilising an internal model of the battery system to plan the future response of the charging and discharging process. Emphasis is given on the effect of the system efficiency, which significantly impacts the economic performance due to energy losses during the charging and discharging cycles.

Background Body-mass index (BMI) and diabetes have increased worldwide, whereas global average blood pressure and cholesterol have decreased or remained unchanged in the past three decades. We quantified how much of the effects of BMI on coronary heart disease and stroke are mediated through blood pressure, cholesterol, and glucose, and how much is independent of these factors. Methods We pooled data from 97 prospective cohort studies that collectively enrolled 1·8 million participants between 1948 and 2005, and that included 57 161 coronary heart disease and 31 093 stroke events. For each cohort we excluded participants who were younger than 18 years, had a BMI of lower than 20 kg/m2, or who had a history of coronary heart disease or stroke. We estimated the hazard ratio (HR) of BMI on coronary heart disease and stroke with and without adjustment for all possible combinations of blood pressure, cholesterol, and glucose. We pooled HRs with a random-effects model and calculated the attenuation of excess risk after adjustment for mediators. Findings The HR for each 5 kg/m2 higher BMI was 1·27 (95% CI 1·23-1·31) for coronary heart disease and 1·18 (1·14-1·22) for stroke after adjustment for confounders. Additional adjustment for the three metabolic risk factors reduced the HRs to 1·15 (1·12-1·18) for coronary heart disease and 1·04 (1·01-1·08) for stroke, suggesting that 46% (95% CI 42-50) of the excess risk of BMI for coronary heart disease and 76% (65-91) for stroke is mediated by these factors. Blood pressure was the most important mediator, accounting for 31% (28-35) of the excess risk for coronary heart disease and 65% (56-75) for stroke. The percentage excess risks mediated by these three mediators did not differ significantly between Asian and western cohorts (North America, western Europe, Australia, and New Zealand). Both overweight (BMI ≥25 to

A new chiral lithium amide has been designed starting from ( S )-proline. This new chiral lithium amide has been used for asymmetric deprotonation/ring opening of cyclohexene oxide to give ( S )-2-cyclohexen-1-ol in 88% yield and 78% enantiomeric excess. NMR studies of the lithium amide and the ligand–substrate complex are also presented.

Distal deep digital flexor tendinopathy is an important cause of foot lameness in horses that is difficult to diagnose with radiography and ultrasonography. Magnetic resonance imaging is a well-accepted and validated technique for the identification of deep digital flexor tendon (DDFT) lesions, but has some practical and financial drawbacks. Contrast-enhanced computed tomography (CECT) has been proposed as a suitable alternative, but validation studies are currently lacking.To assess the accuracy of CECT for the identification and characterisation of deep digital flexor tendinopathy.Descriptive study of CT, macroscopic and histological findings of the DDFT.Plain and CECT scans were acquired of 23 limbs of 16 horses with clinical lameness localised to the foot. All horses had lesions of the DDFT that were identified and characterised with CT and CECT with respect to their anatomic location and extent. All horses underwent post mortem examination and gross abnormalities were described. Samples of the DDFT were taken at specific sites (lesion and nonlesion) for histological evaluation. Macroscopic and histological outcomes were compared with CECT findings.Of 67 sites in 23 DDFTs that were evaluated, 42 sites in 18 tendons had lesions on CECT images. These 42 sites also had lesions on macroscopic evaluation. There were 3 false negative and 3 false positive results identified on CECT. The sensitivity of CECT for diagnosing lesions of the DDFT in the equine foot was 93%.CECT is an effective adjunct to the more commonly used diagnostic techniques in equine foot pain.

Background:Several reports suggest that variance in personality traits is inherited, but little is known about the genes responsible. It has been suggested that there is a relationship between personality characteristics and the gene responsible for the activity of the enzyme debrisoquine 4-hydroxylase (CYP2D6).Objective:To examine the proportion of poor metabolizers in a group of personality disordered patients.Methods:Blood samples were obtained from 23 patients with a high or very high score on the dimension ‘harm avoidance’ of the Temperament and Character Inventory (TCI). The samples were genotyped for the null alleles CYP2D6*3 and*4 by performing an allele-specific polymerase chain reaction.Results:The frequencies of genotypes in the sample were very similar to the frequencies found in a general white population.Conclusions:The investigation produced no support for the idea that the CYP2D6 gene is related to personality by means of variations in the temperament dimension of harm avoidance.

Objective The purpose of this study was to assess the frequency of persistent drug-induced movement disorders namely, tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia in a representative sample of long-stay patients with chronic severe mental illness. Method Naturalistic study of 209, mainly white, antipsychotic-treated patients, mostly diagnosed with psychotic disorder. Of this group, the same rater examined 194 patients at least two times over a 4-year period, with a mean follow-up time of 1.1 years, with validated scales for TD, parkinsonism, akathisia, and tardive dystonia. Results The frequencies of persistent movement disorders in the sample were 28.4% for TD, 56.2% for parkinsonism, 4.6% for akathisia and 5.7% for tardive dystonia. Two-thirds of the participants displayed at least one type of persistent movement disorder. Conclusions Persistent movement disorder continues to be the norm for long-stay patients with chronic mental illness and long-term antipsychotic treatment. Measures are required to remedy this situation.

Most of the cases of aortoenteric fistula are due to aneurysm of the aorta, although infection, tumor, radiotherapy, gastric ulcers and foreign body ingestion have also been described in the literature. We report the case of a 62-year-old woman presenting with massive gastrointestinal bleeding with hematemesis and melaena. This case is unique in that the primary aortoduodenal (PADF) fistula formed as a result of complex atherosclerotic disease of the abdominal aorta and both iliacal arteries, also known as Leriche's syndrome, and not primarily due to an aneurysm. We will give a brief summary of the difficulties and challenges which the surgeon faced during the operation and a surprisingly uneventful postoperative course.

The clinical safety and efficacy of imipenem/cilastatin in the treatment of intra-abdominal infections was compared with the combination of aztreonam and clindamycin in a randomized prospective trial. The severity of illness was determined by means of the Apache II score and a fixed outcome reporting scheme was used. One hundred and four patients were entered into the study, of whom 80 were evaluable. Forty-two patients were treated with imipenem/cilastatin (500 + 500 mg qds) and 38 with aztreonam (600 tds) and clindamycin (1000 mg tds). The study groups were comparable for age and sex. The imipenem/cilastatin group differed from the aztreonam and clindamycin group in having significantly more patients with the diagnosis of acute appendicitis (P < 0.01) and a significantly lower mean Apache score (P < 0.05). The predominate microorganisms isolated in both groups were Escherichia coli and Bacteroides fragilis. Treatment with imipenem/cilastatin proved successful in 71% and failed in 24%, and initial success only was seen in 5%. The numbers in the group treated with aztreonam and clindamycin were 64%, 29% and 7% respectively. Severity of illness, as measured by Apache II score, had no influence on the study outcome. Imipenem/cilastatin as well as the combination of aztreonam and clindamycin were effective in the treatment of abdominal infections and no major adverse reactions were seen.

Met literatuur, samenvatting en bijlagen

Met literatuur, samenvatting en bijlage

Summary: Resume: Zusammenfassung A simulation model for crop-weed competition, parameterized for sugar beet and Chenopodium album L., was validated with experimental data from five field experiments. Between the experiments, 98% of the variation in yield loss, ranging from –6 to 96%, was explained by the simulation model. After validation, the model was used to analyse the backgrounds of the distinct differences in yield loss between the experiments. The contribution of differences in water shortage appeared to be negligible. The number of days between crop and weed emergence, which ranged from 0–31 days, appeared to be the main factor responsible for the differences in yield loss between the experiments (96%). Further analysis showed that water shortage only influences competitive strength of the weeds when overtopped by the crop. Temperature in the period between crop and weed emergence appeared to be an important factor determining the competitive relationships. It is concluded that the period between crop and weed emergence should be expressed as a developmental measure (i.e. degree days) instead of days. Morphological characteristics such as the relative growth rate of leaf area in early growth phases, specific leaf area and height increase largely determined the competitive strength of a species. The effect of physiological characteristics, such as maximum rate of leaf photosynthesis, was less significant. Un modele ecophysiologique pour la competition interspecifique appliquea l'influence de Chenopodium album L. sur la betterave sucriere II. Evaluation du modele Un modele de simulation de la competition culture/adventice, parametre pour la betterave et Chenopodium album L. a ete valide avec des donnees experimentales issues de 5 essais de plein champ. Entre les essais, 98% de la variation de perte de rendement, allant de – 6 a 96%etaient expliques par le modele de simulation. Apres validation, le modele a ete utilise pour analyser les courbes des differences de pertes de rendement entre les essais. Les differences liees au manque d'eau sont negligeables. Le nombre de jour entre la levee de la culture et de l'adventice qui a varie de 0 a 31 jours, est apparu etre le principal facteur responsable des differences entre perte de rendement entre les essais (96%). D'autres analyses ont montre que le manque d'eau influence seulement la vigueur de competition des adventices quand elles sont recouvertes par la culture. La temperature de la periode entre la levee de la culture et de l'adventice apparait etre un important facteur determinant les relations de competition. II estconclu que la periode entre la levee de la culture et de l'adventice devrait etre exprimee en mesure de developpement (par exemple en degres/jour plutot qu'en jour). Des caracteristiques morphologiques comme le taux de croissance relative de la surface foliaire dans les premiers stades, la surface specifique foliaire et l'augmentation de hauteur, determinent grandement la vigueur de competition d'une espece. Les effets des caracteristiques physiologiques comme le taux maximum de la photosynthese foliaires sont moins significatifs. Ein okophysiologisches Modell der interspezifischen Konkurrenz von Chenopodium album auf die Zuckerrube. II. Validierung Ein Simulationsmodell zur Konkurrenz zwischen Kulturpflanze und Unkraut, hier Zuckerrube (Beta vulgaris L.) und Weiser Gansefus (Chenopodium album L.), wurde anhand von Daten aus 5 Freilandversuchen validiert. 98% der Variation der Ertragsverluste, die zwischen –6 und 96% lagen, wurden anhand des Modells erklart. Nach der Validierung wurden mit dem Modell die Bestimmungsgrunde fur die jeweiligen Unterschiede der Ertragsverluste analysiert. Der Beitrag von Unterschieden des Wassermangels erschien als vernachlassigbar. Die Konkurrenzkraft der Unkrauter wurde durch Wassermangel nur beeinflust, wenn sie von der Kulturpflanze uberwachsen wurden. Die Anzahl der Tage zwischen dem Auflaufen der Kulturpflanze und der Unkrautart, das 0 bis 31 Tage auseinander lag, erwies sich als groster Faktor fur die Ertragsverlustunterschiede (96%). Die Temperatur wahrend der Keimperiode war fur die Bestimmung der Konkurrenzbeziehungen wichtig. Deshalb sollte die Keimperiode zwischen Kulturpflanze und Unkraut mit einem Entwicklungsmas (d.h. Temperatursummen) anstatt in Tagen bemessen werden. Morphologische Kenndaten wie relative Wuchsrate der Blattflache in fruhen Entwicklungsstadien, spezifische Blattflache und Wuchshohe bestimmten die Konkurrenzkraft einer Art in hohem Mase. Physiologische Daten wie maximale Photosyntheserate waren weniger signifikant.

In 2007 a national guideline on perioperative nutrition was issued in the Netherlands. As external indicator for adequacy of nutritional therapy, the percentage of malnourished patients who reach at least 1.2 grams of protein on day 4 after admission was chosen by the Netherlands Health Care Inspectorate.We developed an algorithm that allows users to ask for advice on which artificial nutritional formula to prescribe and at which rate, assuring provision of adequate amounts of both protein and energy. Feedback on nutritional therapy is given to the users on a daily basis, and to the management per quarter. Both the advice and the feedback have been integrated in our data management system. The advice module is also available on-line.In the baseline situation over the first four quarters (2006) an average of 30.2% of patients who had a full day 4 in our unit reached the protein indicator. In the last six quarters post-implementation, the average percentage reached was 56.5% with values consistently over 50%. Changes were statistically significant at third quarter of 2007 (p0.05) and thereafter (p0.001). Results for day 7 of admission were unaffected, which indicates that targets were reached earlier during hospital stay.Our study shows that integration of nutritional advice and automatically generated feedback to users in a data management system consistently improves delivery of (early) nutrition.

We show, using several proxies, that the real exchange rate in Kenya has moved in accordance with the dependent economy model since 1975. The adjustment policy supported by the International Monetary Fund (IMF) in the first half of the 1980s led to a rise in the Kenyan real exchange rate and an improvement of its external position. Macroeconomic policy since 1986, however, has resulted in a deterioration of the external position and is likely to result in a reduction in the real exchange rate in the near future.

Dans la perspective de l'histoire du continent africain, le colonialisme européen n'est guère qu'un épisode qui, comme le souligne l'historien nigérien Ajayi, durait dans la plupart des cas moins d'un siècle. Et pourtant, ajoute cette personnalité, la dominance politique européenne et ses prolongements, tels que le christianisme, l'enseignement occidental, les idées politiques et sociales, ont laissé une empreinte durable sur les institutions africaines. De même, la géopolitique a fixé des unités selon lesquelles l'Afrique a été subdivisée, et qui ont en majorité peu changé après la décolonisation. Mais Ajayi rappelle qu'il ne faut sous-estimer les initiatives des Africains, la réaction contre la violation des institutions africaines. La population a souvent su tirer exploiter les conditions nouvelles à son propre profit, soit en collaborant jusqu'à un certain point avec le système, soit en pratiquant une résistance active ou passive couronnée de succès.

This article reports the use of classical light scattering to study cellulose in the NH3/NH4SCN solvent system. Three solvent compositions were used, 27.01 73.0,25.5/ 74.5, and 24.51 75.5 weight ammonia/weight ammonium thiocyanate. The coefficient, (dn/dc)υ, was determined by back calculating using the molecular weight determined by solution viscometry in the solvent system cupriethylenediamine and the classical light-scattering results. Second virial coefficients were found to be similar to those values measured for cellulose in the FeTNa and LiCl/DMAC solvent systems. The characteristic ratios were found to vary with solvent composition with the highest values being at a composition of 25.5/74.5 weight ammonia/ weight ammonium thiocyanate. Persistence lengths were also found to vary with solvent composition with the highest value being 264 × 10−8 cm at solvent composition 25.5/74.5.

This is the second part of a two–part study of the NH3NH4SCN cellulose solvent system. Quasielastic light scattering was used to determine the diffusion coefficients of cellulose in solution and the effective hydrodynamic radius of the dissolved molecules. Additionally, the system was studied using light microscopy to determine the minimum critical volume fraction or liquid crystal formation. Very little change was found in the diffusion coefficients with change in cellulose concentration indicating little interaction between the chains in solution. Values of 7.69 and 2.66 × 108 cm2/s were measured for samples having a degree of polymerization of 153 and 969. The value of the coefficient relating the hydrodynamic volume to the radius of gyration was found to be in the range of 0.33 to 0.53, indicating an extended coil conformation according to the Kirkwood-Riseman theory. The minimum critical volume fractions necessary for liquid crystal formation, υ2′ were 0.039, 0.038, and 0.048 for the three solvent compositions studied. The values calculated for υ2′ based on the measured persistence lengths were much larger than the predicted values, indicating strong deviation from theory or possible aggregation in the system.

A large amount of Zenith endovascular stent complications is due to problems with the leg extensions. This kind of complication has never been reported in literature. The aim of this study was to monitor the complications of endovascular abdominal aneurysm repair (EVAR) performed with the Zenith endovascular graft occurred in the Amphia Ziekenhuis in Breda to see how many recurrences were due to leg extension.The study enrolled all patients (N.=66) treated with the Zenith endograft in the period between October 2000 and September 2006. Mortality, complications and the number of reinterventions were analysed. Average age of the patients was 73.4 years, average follow-up was 24.5 months and average aneurysm size was 61.5 mm. Radiologic follow-up was performed by computed tomography scans and X-rays.Postoperative mortality rate was 0%. The overall mortality rate during follow-up was 3%. Ten patients required a total number of 12 reinterventions (15%). The average time for reintervention was 10 months after the primary operation. Mortality, complication and reintervention rates were comparable with those reported in the literature, but 75% of these reinterventions were related to the leg extensions.Authors observed that nine out of 12 complications which required reintervention were due to problems with one of the leg extensions. This is the first study that specifies clearly the percentage of problems with leg extensions in EVAR (75%). When placing a Zenith endovascular graft extra attention should be paid to optimal placement of the leg extensions.

Background Modern omics research involves the application of high-throughput technologies that generate vast volumes of data. These data need to be pre-processed, analyzed and integrated with existing knowledge through the use of diverse sets of software tools, models and databases. The analyses are often interdependent and chained together to form complex workflows or pipelines. Given the volume of the data used and the multitude of computational resources available, specialized pipeline software is required to make high-throughput analysis of large-scale omics datasets feasible. Results We have developed a generic pipeline system called Cyrille2. The system is modular in design and consists of three functionally distinct parts: 1) a web based, graphical user interface (GUI) that enables a pipeline operator to manage the system; 2) the Scheduler, which forms the functional core of the system and which tracks what data enters the system and determines what jobs must be scheduled for execution, and; 3) the Executor, which searches for scheduled jobs and executes these on a compute cluster. Conclusion The Cyrille2 system is an extensible, modular system, implementing the stated requirements. Cyrille2 enables easy creation and execution of high throughput, flexible bioinformatics pipelines.

To obtain a suitable species-specific microflora for a new rat SPF-unit, germ-free WAG/Rij rats were associated with a flora derived originally from selectively decontaminated Cpb:WU (Wistar) rats. Caecal and ileal contents of these rats had been cultured anaerobically (37°C) for 7 days and harvested. This cultured flora was given to germ-free Cpb : SE (Swiss) mice, which were kept in an isolator system and acted as a source of the flora to associate germ-free Wag/Rij rats. In these associated rats, several parameters indicative of the 'quality' of the intestinal micro flora were investigated and compared to those in rats with a mouse derived anaerobic microflora. Parameters included relative caecal weight, colonization resistance and the concentration of faecal bile acids. The cultured rat-derived microflora normalized the observed intestinal parameters better than the mouse derived microflora, and provided better colonization resistance. We conclude that culturing of intestinal contents of selectively decontaminated animals can be a useful way to obtain a species-specific donor-micro flora which can be used to start new SPF units.

Projectnr.: 176107.

Projectnr.: 176080

Projectnr.: 176058

Projectnr.: 176068

[1] Gas transfer rates were determined from vertical profile measurements of atmospheric dimethylsulfide (DMS) gradients over the equatorial Pacific Ocean obtained during the GasEx-2001 cruise. A quadratic relationship between gas transfer velocity and wind speed was derived from the DMS flux measurements; this relationship was in close agreement with a parameterization derived from relaxed eddy accumulation measurements of DMS over the northeastern Pacific Ocean. However, the GasEx-2001 relationship results in gas transfer rates that are a factor 2 higher than gas transfer rates calculated from a parameterization that is based on coincident eddy correlation measurements of CO2 flux. The measurement precision of both the profiling and eddy correlation techniques applied during GasEx-2001 is comparable; the two gas transfer data sets are in agreement within their uncertainty. Differences in the number of samples and the wind speed range over which CO2 and DMS fluxes were measured are likely causes for the observed discrepancy.

[1] Gas transfer rates were determined from relaxed eddy accumulation ( REA) measurements of the flux of dimethylsulfide (DMS) over the northeastern Pacific Ocean. This first application of the REA technique for the measurement of DMS fluxes over the open ocean produced estimates of the gas transfer rate that are on average higher than those calculated from commonly used parameterizations. The relationship between the total gas transfer rate and wind speed was found to be gas k(gas) = 0.53 (+/-0.05) U-10(2). Because of the effect of the airside resistance, the waterside transfer rate was up to 16% higher than kgas. Removal of the airside transfer component from the total transfer rate resulted in a relation between wind speed and waterside transfer of k(660) = 0.61 (+/-0.06) U-10(2). However, DMS fluxes showed a high degree of scatter that could not readily be accounted for by wind speed and atmospheric stability. It has to be concluded that these measurements do not permit an accurate parameterization of gas transfer as a function of wind speed.

Maroon societies consisted of runaway slaves and their offspring who sequestered themselves in the circum-Caribbean wilderness.1 The existence of Maroons manifested the opposition of some African slaves to their enslavement and a persistent desire to create a free society of their own. In the Western hemisphere, Maroon societies emerged virtually whenever and wherever a slave population existed. None the less, at any given time, Maroons comprised no more than a tiny fraction of the local Afro Caribbean community. The survival of Maroon societies depended on a combination of circumstances, not only the local geography, but also the local social, political and military resources of the Maroons and neighbouring slaveholders.

Interleukin-2 (IL-2) is a powerful drug for treating cancer. However, it is only powerful if it is properly applied. That is, IL-2 should be applied at the tumor site, because at the transition of normal and malignant tissue are the tumor infiltrating cells. These should be activated by IL-2. Local application implies that IL-2 can be used in relatively low doses. It is becoming clear that even a single injection of IL-2 can cure cancer. IL-2 can also enhance the therapeutic effects of irradiation and Cisplatin. Locally applied IL-2 therapy is virtually non-toxic.

Background: Adrenal Cushing's syndrome caused by ACTH-independent macronodular adrenocortical hyperplasia (AIMAH) can be accompanied by aberrant responses to hormonal stimuli. We investigated the prevalence of adrenocortical reactions to these stimuli in a large cohort of AIMAH patients, both in vivo and in vitro.Methods: In vivo cortisol responses to hormonal stimuli were studied in 35 patients with ACTH-independent bilateral adrenal enlargement and (sub-) clinical hypercortisolism. In vitro, the effects of these stimuli on cortisol secretion and steroidogenic enzyme mRNA expression were evaluated in cultured AIMAH and other adrenocortical cells. Arginine-vasopressin (AVP) receptor mRNA levels were determined in the adrenal tissues.Results: Positive serum cortisol responses to stimuli were detected in 27/35 AIMAH patients tested, with multiple responses within individual patients occurring for up to four stimuli. AVP and metoclopramide were the most prevalent hormonal stimuli triggering positive responses in vivo. Catecholamines induced short-term cortisol production more often in AIMAH cultures compared to other adrenal cells. Short-and long-term incubation with AVP increased cortisol secretion in cultures of AIMAH cells. AVP also increased steroidogenic enzyme mRNA expression, among which an aberrant induction of CYP11B1. AVP type 1a receptor was the only AVPR expressed and levels were high in the AIMAH tissues. AVPR1A expression was related to the AVP-induced stimulation of CYP11B1.Conclusions: Multiple hormonal signals can simultaneously induce hypercortisolism in AIMAH. AVP is the most prevalent eutopic signal and expression of its type 1a receptor was aberrantly linked to CYP11B1 expression.

In this report we present studies on optimal regimes for regional IL-2 therapy, focused on dose, schedule and site of injection. Original data obtained in 2 murine tumour models show that all 3 factors are of importance. Anti-tumour responses were most effective when IL-2 was administered regionally 5 to 10 times, at doses ranging from 7,000 to 33,000 IU/day every day or every other day. This resulted in cure rates of more than 40% in mice bearing ascitic tumour that had also disseminated to liver and lungs. The importance of these data is discussed in the light of previous results of our group. These results illustrate that the doses and schedules used in this study are not effective exclusively in these 2 tumour models but may have a more general applicability.

Spontaneous Raman spectroscopy was utilized in an experimental investigation of vibrational nonequilibrium in hydrogen-oxygen rocket engines. Oxygen temperatures were measured at subsonic, sonic, and supersonic portions of the nozzle flow. Rotational temperatures were determined from rotational Raman scattering. Both rotational and vibrational temperatures were determined from vibrational-rotational Raman spectra. Rotational temperatures from the two types of Raman scattering agree within the very large experimental error present. Vibrational temperatures are in agreement with rotational temperatures within the experimental error as well. Vibrational Raman spectroscopy is shown to be a valid means of estimating rotational temperatures within the rocket chamber and at low nozzle area ratios. Flowfield effects due to vibrational nonequilibrium are concluded to be minor. (Author)

Rye and grass cover crops can potentially intercept residual soil mineral nitrogen (SMN), reduce overwinter leaching, transfer SMN to next growing seasons and reduce the fertilizer need of subsequent crops. These aspects were studied for 6 years in continuous silage maize cv. LG 2080 production systems receiving 20-304 kg N/ha, on a sandy soil in the Netherlands. Rye cv. Admiraal and grass (Lolium multiflorum cv. Combita) cover crops were able to absorb on average 40 kg N/ha into the shoots. The actual N uptake was largely determined by winter temperatures and hardly affected by residual SMN. At low N input levels cover crops reduced N leaching in accordance with their N uptake. At high N input levels, however, the reduction of leaching losses exceeded the storage capacity of the cover crop, suggesting that cover cropping stimulated the loss of N via denitrification or immobilization. Cover crops had no positive effect on maize yields at larger N rates and under these conditions cover crops did not improve the conversion of SMN into crop N. This was only partly reflected by an increase of residual SMN on plots where cover crops had been incorporated, as a large part of the excess N applied to maize was already lost during the growing season. In N-deficient maize production systems, however, cover crops increased the dry matter yield of maize. Their effect was equivalent to the effect of fertilizer N rates amounting to 105 and 44% of the shoot N in rye and L. multiflorum, respectively. In the first few years cover crops decomposed incompletely during the growing season following their incorporation. In the course of the years, however, effects on subsequent maize crops increased. This supports the hypothesis that the effects of cover crops are cumulative when grown repeatedly. Averaged over the 6 years, 115% and 73% of the shoot rye N and L. multiflorum N, respectively, were recovered in the crop-soil system.

To assess and compare the quality of life of patients treated with haemodialysis and chronic ambulatory peritoneal dialysis (CAPD) in Utrecht and Willemstad, Curaçao.Transverse multicentre study.All haemodialysis and CAPD patients in Utrecht and all haemodialysis patients in Curaçao under treatment for over 6 months were studied. The objective tests applied were the 'Nottingham health profile', the 'affect balance scale', the 'index of well-being' and the 'Amsterdam complaint profile'. Possible correlations between individual patient-related and treatment-related factors and biochemical variables were also investigated.The objective and subjective tests revealed only slight differences in quality of life in the three groups. In a few respects, the CAPD patients rated the quality of life slightly better. In the Utrecht group a positive relationship was seen between haematocrit (higher owing to treatment with erythropoietin) and plasma bicarbonate concentration, and the quality of life.

(1985). A comparison between the history of Maroon communities in Surinam and Jamaica. Slavery & Abolition: Vol. 6, Out of the House of Bondage: Runaways, Resistance and Marronage in Africa and the New World, pp. 173-184.

M.A. van Bakel, H. Esen-Baur, Untersuchungen über den vogelmann-kult auf der Osterinsel, 1983, Franz Steiner Verlag GmbH, 399 pp. - Leen Boer, Bronislaw Malinowski, Malinowski in Mexico. The economics of a Mexican market system, edited and with an introduction by Susan Drucker-Brown, London: Routledge and Kegan Paul, 1982 (International Library of Anthropology)., Julio de la Fuente (eds.) - A.P. Borsboom, Betty Meehan, Shell bed to shell midden, Australian Institute of Aboriginal Studies, Canberra, 1982. - H.J.M. Claessen, Peter Geschiere, Village communities and the state. Changing relations among the Maka of Southeastern Cameroon since the colonial conquest. Monographs of the African Studies Centre, Leiden. London: Routledge and Kegan Paul Ltd. 1982. 512 pp. Appendices, index, bibliography, etc. - H.J.M. Claessen, Jukka Siikala, Cult and conflict in tropical Polynesia; A study of traditional religion, Christianity and Nativistic movements, Helsinki: Academia Scientiarum Fennica, 1982, 308 pp. Maps, figs., bibliography. - H.J.M. Claessen, Alain Testart, Les Chasseurs-Cueilleurs ou l’Origine des Inégalités, Mémoires de la Sociéte d’Ethnographie 26, Paris 1982. 254 pp., maps, bibliography and figures. - Walter Dostal, Frederik Barth, Sohar - Culture and society in an Omani town. Baltimore - London: The Johns Hopkins University Press, 1983, 264 pp., ill. - Benno Galjart, G.J. Kruyer, Bevrijdingswetenschap. Een partijdige visie op de Derde Wereld [Emancipatory Science. A partisan view of the Third World], Meppel: Boom, 1983. - Sjaak van der Geest, Christine Okali, Cocoa and kinship in Ghana: The matrilineal Akan of Ghana. London: Kegan Paul International (in association with the International African Institute), 1983. 179 pp., tables, index. - Serge Genest, Claude Tardits, Contribution de la recherche ethnologique à l’histoire des civilisations du Cameroun / The contribution of enthnological research to the history of Cameroun cultures. Paris, CNRS, 1981, two tomes, 597 pp. - Silvia W. de Groot, Sally Price, Co-wives and calabashes, Ann Arbor, The University of Michigan Press, 1984, 224 p., ill. - N.O. Kielstra, Gene R. Garthwaite, Khans and Shahs. A documentary analysis of the Bakhtiary in Iran, Cambridge University Press, Cambridge, 1983. 213 pp. - G.L. Koster, Jeff Opland, Xhosa oral poetry. Aspects of a black South African tradition, Cambridge Studies in oral and literate culture 7, Cambridge University Press, Cambridge , London, New York, New Rochelle, Melbourne, Sydney, 1983, XII + 303 pp. - Adam Kuper, Hans Medick, Interest and emotion: Essays on the study of family and kinship, Cambridge University Press, 1984., David Warren Sabean (eds.) - C.A. van Peursen, Peter Kloos, Antropologie als wetenschap. Coutinho, Muidenberg 1984 (204 p.). - Jerome Rousseau, Jeannine Koubi, Rambu solo’: “la fumée descend”. Le culte des morts chez les Toradja du Sud. Paris: Editions du CNRS, 1982. 530 pages, 3 maps, 73 pictures. - H.C.G. Schoenaker, Miklós Szalay, Ethnologie und Geschichte: zur Grundlegung einer ethnologischen geschichtsschreibung; mit beispielen aus der Geschichte der Khoi-San in Südafrika. Dietrich Reimer Verlag, Berlin 1983, 292 S. - F.J.M. Selier, Ghaus Ansari, Town-talk, the dynamics of urban anthropology, 170 pp., Leiden: E.J. Brill, 1983., Peter J.M. Nas (eds.) - A.A. Trouwborst, Serge Tcherkézoff, Le Roi Nyamwezi, la droite et la gauche. Revision comparative des classifications dualistes. Cambridge: Cambridge University Press, Paris:Éditions de la Maison des sciences de l’homme, 1983, 154 pp. - Pieter van der Velde, H. Boekraad, Te Elfder Ure 32: Verwantschap en produktiewijze, Jaargang 26 nummer 3 (maart 1983)., G. van den Brink, R. Raatgever (eds.) - E.Ch.L. van der Vliet, Sally Humphreys, The family, women and death. Comparative studies. London, Boston etc.: Routledge & Kegan Paul, 1983 (International Library of Anthropology). xiv + 210 pp. - W.F. Wertheim, T. Svensson, Indonesia and Malaysia. Scandinavian Studies in Contemporary Society. Scandinavian Institute of Asian Studies: Studies on Asian Topics no. 5. London and Malmö: Curzon Press, 1983, 282 pp., P. Sørensen (eds.) - H.O. Willems, Detlef Franke, Altägyptische verwandtschaftsbezeichnungen im Mittleren Reich, Hamburg, Verlag Born GmbH, 1983.

Nonelicited peritoneal macrophages obtained from normal mice from our animal house unexpectedly expressed a strong tumor growth stimulatory effect in vitro. Macrophages expressing this stimulatory effect had an aberrant morphology compared to the morphology of normal macrophages as observed by electron microscopy. The results of immunization of these affected mice with tumour cells led to the usual lymphocyte sensitization. No external symptoms were observed, and the mice looked healthy. Treatment of the affected macrophage donors with antibiotics resulted in the abolishment of the tumor growth stimulatory effect by the macrophages. Thus, this tumor cell growth stimulation by marcrophages was probably due to a subclinical infection of the mice.

Experimental investigations of the photovoltaic properties of metal-silicon Schottky barriers are reported, in which edge collection of the photocurrent is dominant as in the majority-carrier grating solar cells proposed by Green. Both elemental metals and alloy Schottky electrodes, and both crystalline and semicrystalline cast silicon have been studied. The superposition principle for dark currents and photocurrents is shown unambiguously to be violated, and the effects of grain-boundary recombination and shunt resistance are identified. Limitations to the operation of these devices above the semiempirical limit of continuous Schottky barrier solar cells is seriously compromised by enhanced space-charge recombination current. This results from the large photocurrent densities for low contact area/active area ratios. The treatment of the space-charge recombination mechanism under optical illumination follows the normal Sah-Noyce-Shockley approach, but we introduce here a built-in “recombination potential” to encompass the non-zero recombination for short-circuit conditions.

DBA/2 mice were immunized against the syngeneic SL2 lymphoma by two or five injections with irradiated lymphoma cells given IP or SC, respectively. The antitumor efficacy induced in immunized mice was tested by (a) IP injection of the immunized mice with nonirradiated tumor cells and (b) transfer of the total 'immune' peritoneal exudate, the cellular fraction only, or the cell-free fraction only, IP into tumor-bearing recipients, or (c) tumor neutralization tests (Winn assay). It was shown that immunized mice were able to reject 5 X 10(7) SL2 tumor cells (8 of 14 mice survived greater than 100 days), while in most transfer experiments 2 X 10(5) SL2 cells could be eradicated. In the tumor neutralization experiments a number of 10(6) SL2 cells were eradicated. When the immune exudates were given before the inoculations of SL2 tumor cells the number of survivors increased significantly. Further, it was shown that the cellular fraction is the major contributor to the antitumor effect in the transfer experiments, since there was no significant difference in tumor eradication after injection of a complete immune exudate and after injection of the isolated cellular fraction. Injection of the noncellular fraction had no measurable antitumor effect. An increase in the number of injections with total peritoneal exudates from immunized mice did not result in an increase in tumor eradication in the tumor-bearing recipients. Extra stimulation (IP) of immunized mice with 10(4) nonirradiated cells 6 days after the last immunization resulted in an increase of the antitumor efficacy of these peritoneal exudates of these mice when collected 4-24 h after this stimulation. Extra stimulation with 10(6) irradiated cells had no measurable effect.

Short-channel MOS transistors exhibit a drain current saturation behaviour different from that of longer channels. By comparing measured and calculated characteristics it is shown that the current increase can be successfully interpreted as a threshold voltage shift proportional to the drain voltage. A circuit model is derived which takes into account the above effect and includes an improved saturation mechanism. Compared with existing models the present one yields smaller deviations between measured and calculated characteristics and does not need non-physical parameters values.

The advent of low-power-requirement electronic distance relays has lead to the possibility of generating low-power test signals for such relays using a minicomputer. Such a test program has been written, for steady-state and transient, i.e. dynamic, testing of distance relays, and the tests performed on an actual relay. The tests are highly automated, with results appearing as "R-X diagram" plots on a CRT screen, and tripping time versus distance-to-fault. It is suggested that this approach can lead to savings in time and expense, as well as increased flexibility, over conventional methods.