51. Low post-arthroplasty infection rate is possible in developing countries: long-term experience of local vancomycin use in Iran.
- Author
-
Tahmasebi MN, Vaziri AS, Vosoughi F, Tahami M, Khalilizad M, and Rabie H
- Subjects
- Aged, Arthroplasty, Replacement, Knee statistics & numerical data, Biosimilar Pharmaceuticals, Drug Utilization statistics & numerical data, Female, Humans, Intraoperative Care, Iran epidemiology, Male, Middle Aged, Retrospective Studies, Surgical Wound Infection etiology, Time Factors, Arthroplasty, Replacement, Knee adverse effects, Prosthesis-Related Infections prevention & control, Surgical Wound Infection epidemiology, Surgical Wound Infection prevention & control, Vancomycin administration & dosage
- Abstract
Background: Utilizing intrawound vancomycin powder in TKA surgery has yielded rather contrasting results in the current literature. Furthermore, CDC criteria, although effective in general, are not specifically designed for post-TKA infections. Here, we present a 7-year experience of vancomycin use in primary TKA in a high-volume tertiary knee center in Iran. Also, new criteria are proposed to detect suspected superficial post-TKA infections., Methods: This is a retrospective analysis of primary total knee arthroplasties performed in a tertiary knee center, from March 2007 to December 2018, by a single senior knee surgeon. All patients with follow-up periods of less than 1 year were excluded from the study. Since March 2011, all patients received vancomycin (powder, 1 g) before water-tight closure of the joint capsule. A comparison was made between this group and historical control subjects (operated from March 2007 to March 2011)., Results: Altogether, 2024 patients were included in the study. The vancomycin and the control groups included 1710 and 314 cases respectively. Patients were mostly women (male to female ratio, 1 to 4), with a mean age of 65.20 (SD = 10.83) years. In the vancomycin group, the rate of suspected SII (1.87%) and PJI (0.41%) was significantly lower than the control group (P = 0.002)., Conclusions: Our experience shows that application of local vancomycin during TKA surgery could be a reasonable infection prevention measure, although prospective randomized studies are required to evaluate its efficacy.
- Published
- 2021
- Full Text
- View/download PDF