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51. Epidemiología de la enfermedad inflamatoria intestinal crónica en cinco áreas de Asturias: España

Author

Saro Gismera, C., primary, Riestra Menéndez, S., additional, Sánchez Fernández, R., additional, Milla Crespo, A., additional, Lacort Fernández, M., additional, Argüelles Fernández, G., additional, Chobak, Z., additional, Florido Mancheño, J. I., additional, Antón Magarzo, J. L., additional, Altadill Arregui, A., additional, Vizoso, F., additional, Pineda García, E., additional, Fernández de Ocariz Archs, E., additional, Albert Colomer, J., additional, García Pérez, J., additional, López Rivas, L., additional, and Lombraña, J. L. S., additional

Published
2003
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55. Incidencia y prevalencia en enfermedad inflamatoria intestinal crónica: Estudio asturiano en cinco áreas (EIICEA). España

Author

Saro Gismera, C., primary, Riestra Menéndez, S., additional, Milla Crespo, A., additional, Sánchez Fernández, R., additional, Lacort Fernández, M., additional, Argüelles Fernández, G., additional, Chovac, Z., additional, Florido Mancheño, J.I., additional, Antón Magarzo, J.L., additional, Altadill Arregui, A., additional, Vizoso, F., additional, Pineda García, E., additional, Fernández de Ocariz Archs, E., additional, Albert Colomer, J., additional, García Pérez, J., additional, López Rivas, L., additional, and S. Lombraña, J.L., additional

Published
2003
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57. Importancia de la edad como factor pronóstico determinante de la variabilidad de las características clínico-patológicas de las pacientes con cáncer de mama

Author

Gava, R. R., primary, Corte, M. G., additional, Vizoso, F., additional, Rodríguez, J. C., additional, Vázquez, J., additional, Lamelas, M. L., additional, Sánchez, M. T., additional, Martín, A., additional, Alonso, L., additional, Idelfonso, C., additional, García Muñiz, J. L., additional, and Abad, M., additional

Published
2002
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79. Correlation between BCM (Breast Cancer Mucin) and CA 549 Serum Levels Cystic Breast Disease

Author

Vizoso F, Ruibal A, Antonio Fueyo, Roiz Mc, and Allende Mt

Subjects
Adult, Oncology, Cancer Research, medicine.medical_specialty, Pathology, Fibrocystic Breast Disease, Clinical Biochemistry, CA 15-3, Pathology and Forensic Medicine, Immunoenzyme Techniques, Breast cancer, Cystic breast disease, Antigens, Neoplasm, Internal medicine, Humans, Medicine, Antigens, Tumor-Associated, Carbohydrate, business.industry, Mucin, Middle Aged, medicine.disease, Immunoenzyme techniques, Female, Antigens neoplasm, business
Published
1990
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91. Matrix Metalloproteinases and Bladder Cancer:What is New?

Author

Faba, O. Rodriguez, Palou-Redorta, J., Fernández-Gómez, J. M., Algaba, F., Eiró, N., Villavicencio, H., and Vizoso, F. J.

Abstract

Urothelial bladder cancer represents a heterogeneous disease with divergent pathways of tumorigenesis. Tumor invasion and progression are a multifactorial process promoted by microenvironmental changes that include overexpression of matrix metalloproteinases (MMPs). Recent data clearly challenge the classic dogma that MMPs promote metastasis only by modulating the remodeling of extracellular matrix. Indeed, MMPs have also been attributed as an impact on tumor cell behavior in vivo as a consequence of their ability to cleave growth factors, cell surface receptors, cell adhesion molecules, and chemokines/cytokines. Levels of the different MMPs can be measured in several sample types, including tissue, blood (serum and plasma), and urine, and using different methodologies, such as immunohistochemistry, real-time PCR, western and northern blot analyses, enzymelinked immunosorbent assay, and zymography. Several MMPs have been identified as having potential diagnostic or prognostic utility, whether alone or in combination with cytology. Although MMP inhibitors have shown limited efficacy, advances in the understanding of the complex physiologic and pathologic roles of MMPsmight permit the development of new MMP-specific and tumor-specific therapies. In this paper we update the understanding of MMPs based on a systematic PubMed search encompassing papers published up to December 2011. [ABSTRACT FROM AUTHOR]

Published
2012

97. Significance of Collagenase 3 (Matrix Metalloproteinase 13) in Invasive Bladder Cancer: Correlation with Pathological Parameters.

Author

Faba, O. Rodríguez, Gómez, J. M. Fernández, Redorta, J. Palou, Barmadah, S. Escaf, Vizoso, F., and Mavrich, H. Villavicencio

Subjects
COLLAGENASES, GENE expression, BLADDER cancer, BLADDER tumors, METALLOPROTEINASES, GENETIC transformation, GENETIC markers
Abstract

Purpose: To determine if collagenase 3 expression is associated with stage progression and prognosis of bladder cancer. Patients and Methods: Immunohistochemical staining for collagenase 3 was carried out on serial sections from specimens of 42 patients (32 males and 10 females) who underwent radical cystectomy for bladder cancer (median follow-up, 67.2 ± 5.99 months). Results: Immunohistochemical expression of collagenase 3 was detected in 13 (31%) patients. Pathological stage was pT2 in 12 (28.57%) patients, pT3a in 7 (16.6%), pT3b in 21 (50%) and pT4 in 2 (4.76%). Four tumours (9.52%) were grade II and 38 (90.47%) were grade III. Stage and tumours >3 cm in size were associated with bladder cancer progression-free survival and overall survival. We did not find any statistical differences with collagenase 3 expression related with stage and size. Conclusions: Immunohistochemical expression of matrix metalloproteinase 13 in invasive bladder cancer is not useful as marker for transformation and invasion. These findings should be evaluated in large multicentre prospective trials. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2007
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