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55. Handling New Adversaries in Wireless Ad-Hoc Networks (Transcript of Discussion)

Author

Gligor, Virgil D., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Christianson, Bruce, editor, Malcolm, James A., editor, Matyas, Vashek, editor, and Roe, Michael, editor

Published
2011
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78. Guaranteeing Access in Spite of Distributed Service-Flooding Attacks : (Transcript of Discussion)

Author

Gligor, Virgil D., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Christianson, Bruce, editor, Crispo, Bruno, editor, Malcolm, James A., editor, and Roe, Michael, editor

Published
2005
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81. On Trust Establishment in Mobile Ad-Hoc Networks

Author

Eschenauer, Laurent, Gligor, Virgil D., Baras, John, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Christianson, Bruce, editor, Crispo, Bruno, editor, Malcolm, James A., editor, and Roe, Michael, editor

Published
2004
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87. On the Negotiation of Access Control Policies

Author

Gligor, Virgil D., Khurana, Himanshu, Koleva, Radostina K., Bharadwaj, Vijay G., Baras, John S., Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Christianson, Bruce, editor, Malcolm, James A., editor, Crispo, Bruno, editor, and Roe, Michael, editor

Published
2002
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95. Integrity-Aware PCBC Encryption Schemes

Author

Gligor, Virgil D., Donescu, Pompiliu, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Christianson, Bruce, editor, Crispo, Bruno, editor, Malcolm, James A., editor, and Roe, Michael, editor

Published
2000
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96. Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression

Author

Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, and Virgil Dalm

Subjects
CVID, Depression, Thymalfasin, Therapy, Improvement, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: A considerable proportion (21%) of patients with common variable immunodeficiency (CVID) suffers from depression. These subjects are characterized by reduced naïve T cells and a premature T cell senescence similar to that of patients with major depressive disorder (MDD). It is known that T cells are essential for limbic system development/function. Treatment with thymosin α1 (Tα1) is capable to increase the thymus output of naïve T cells. Objective: To treat CVID patients with a comorbid depressive episode with Tα1 to increase naïve T cells and thereby improve mood. Design: A small open-label, proof of concept trial. Five depressed CVID patients (Hamilton Depression Rating Scale, HDRS >12) could be treated with Tα1 (8 weeks, 1.6 mg daily subcutaneously, 1st week, thereafter 1.6 mg twice weekly). At the start, at 8 weeks and 8 weeks after the last injection, the HDRS was recorded and blood samples drawn for measuring naïve and memory T cells, Th17 and Treg cells, hsCRP, IL-6 and IL-7. Outcomes were compared to those of a contrast group (42 MDD patients, same severity but treated as usual (TAU)). Results: In all 5 depressed CVID patients HDRS decreased during Tα1 treatment (with average 52%, TAU decreased scores with 36% in MDD patients). All 5 CVID patients showed an increase in naïve/memory CD4+ and CD8+ T cell ratios, and in 4 of the 5 patients with detectable IL-6 levels reductions were recorded. TAU did not show such immune improvements. In the 8-week wash-out, depression recurred in the 2 most severe patients, while continued to improve in the others. Immune effects were not sustained in the wash-out. Conclusion: This preliminary small study suggests thymus hormone treatment to have antidepressive and related immune correcting effects. Data urge for larger placebo-controlled trials.

Published
2025
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