99 results on '"Vilas, Dolores"'
Search Results
52. Impaired cerebral microcirculation in isolated REM sleep behaviour disorder
- Author
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Eskildsen, Simon F, primary, Iranzo, Alex, additional, Stokholm, Morten G, additional, Stær, Kristian, additional, Østergaard, Karen, additional, Serradell, Mónica, additional, Otto, Marit, additional, Svendsen, Kristina B, additional, Garrido, Alicia, additional, Vilas, Dolores, additional, Borghammer, Per, additional, Santamaria, Joan, additional, Møller, Arne, additional, Gaig, Carles, additional, Brooks, David J, additional, Tolosa, Eduardo, additional, Østergaard, Leif, additional, and Pavese, Nicola, additional
- Published
- 2021
- Full Text
- View/download PDF
53. Genome-wide association studies of LRRK2 modifiers of Parkinson's disease
- Author
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Lai, Dongbing, primary, Alipanahi, Babak, additional, Fontanillas, Pierre, additional, Schwantes-An, Tae-Hwi, additional, Aasly, Jan, additional, Alcalay, Roy N., additional, Beecham, Gary W., additional, Berg, Daniela, additional, Bressman, Susan, additional, Brice, Alexis, additional, Brockman, Kathrin, additional, Clark, Lorraine, additional, Cookson, Mark, additional, Das, Sayantan, additional, Deerlin, Vivianna Van, additional, Farrer, Matthew, additional, Trinh, Joanne, additional, Gasser, Thomas, additional, Goldwurm, Stefano, additional, Gustavsson, Emil, additional, Klein, Christine, additional, Lang, Anthony E., additional, Langston, William J., additional, Latourelle, Jeanne, additional, Lynch, Timothy, additional, Marder, Karen, additional, Marras, Connie, additional, Martin, Eden R., additional, McLean, Cory Y., additional, Mejia-Santana, Helen, additional, Molho, Eric, additional, Myers, Richard H., additional, Nuytemans, Karen, additional, Ozelius, Laurie, additional, Payami, Haydeh, additional, Raymond, Deborah, additional, Rogaeva, Ekaterina, additional, Rogers, Michael P., additional, Ross, Owen A., additional, Samii, Ali, additional, Saunders-Pullman, Rachel, additional, Schule, Birgitt, additional, Schulte, Claudia, additional, Scott, William K., additional, Tanner, Caroline, additional, Tolosa, Eduardo, additional, Tomkins, James E., additional, Vilas, Dolores, additional, Trojanowski, John Q., additional, Uitti, Ryan, additional, Vance, Jeffery M., additional, Visanji, Naomi P., additional, Wszolek, Zbigniew K., additional, Zabetian, Cyrus P., additional, Mirelman, Anat, additional, Giladi, Nir, additional, Urtreger, Avi Orr, additional, Cannon, Paul, additional, Fiske, Brian, additional, and Foroud, Tatiana, additional
- Published
- 2020
- Full Text
- View/download PDF
54. Co-morbid demyelinating lesions and atypical clinical features in a patient with Parkinson's disease
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Rodriguez-Diehl, Roberta, Vilas, Dolores, Bargalló, Nuria, Tolosa, Eduardo, and Gelpi, Ellen
- Published
- 2019
- Full Text
- View/download PDF
55. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
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Thomalla, Götz, primary, Boutitie, Florent, additional, Ma, Henry, additional, Koga, Masatoshi, additional, Ringleb, Peter, additional, Schwamm, Lee H, additional, Wu, Ona, additional, Bendszus, Martin, additional, Bladin, Christopher F, additional, Campbell, Bruce C V, additional, Cheng, Bastian, additional, Churilov, Leonid, additional, Ebinger, Martin, additional, Endres, Matthias, additional, Fiebach, Jochen B, additional, Fukuda-Doi, Mayumi, additional, Inoue, Manabu, additional, Kleinig, Timothy J, additional, Latour, Lawrence L, additional, Lemmens, Robin, additional, Levi, Christopher R, additional, Leys, Didier, additional, Miwa, Kaori, additional, Molina, Carlos A, additional, Muir, Keith W, additional, Nighoghossian, Norbert, additional, Parsons, Mark W, additional, Pedraza, Salvador, additional, Schellinger, Peter D, additional, Schwab, Stefan, additional, Simonsen, Claus Z, additional, Song, Shlee S, additional, Thijs, Vincent, additional, Toni, Danilo, additional, Hsu, Chung Y, additional, Wahlgren, Nils, additional, Yamamoto, Haruko, additional, Yassi, Nawaf, additional, Yoshimura, Sohei, additional, Warach, Steven, additional, Hacke, Werner, additional, Toyoda, Kazunori, additional, Donnan, Geoffrey A, additional, Davis, Stephen M, additional, Gerloff, Christian, additional, Acosta, Boris Raul, additional, Aegidius, Karen, additional, Albiker, Christian, additional, Alegiani, Anna, additional, Almendrote, Miriam, additional, Alonso, Angelika, additional, Althaus, Katharina, additional, Amarenco, Pierre, additional, Amiri, Hemasse, additional, Anders, Bettina, additional, Aniculaesei, Adriana, additional, Appleton, Jason, additional, Arenillas, Juan, additional, Back, Christina, additional, Bähr, Christian, additional, Bardutzky, Jürgen, additional, Baronnet-Chauvet, Flore, additional, Bathe-Peters, Rouven, additional, Bayer-Karpinska, Anna, additional, Becerra, Juan L., additional, Beck, Christoph, additional, Belchí Guillamon, Olga, additional, Benoit, Amandine, additional, Berhoune, Nadia, additional, Bindila, Daniela, additional, Birchenall, Julia, additional, Blanc-Lasserre, Karine, additional, Blanco Gonzales, Miguel, additional, Bobinger, Tobias, additional, Bodechtel, Ulf, additional, Bodiguel, Eric, additional, Bojaryn, Urszula, additional, Bonnet, Louise, additional, Bouamra, Benjamin, additional, Bourgeois, Paul, additional, Breuer, Lorenz, additional, Breynaert, Ludovic, additional, Broughton, David, additional, Brouns, Raf, additional, Brugirard, Sébastian, additional, Bruneel, Bart, additional, Buggle, Florian, additional, Cakmak, Serkan, additional, Calleja, Ana, additional, Calvet, David, additional, Carrera, David, additional, Chen, Hsin-Chieh, additional, Cheripelli, Bharath, additional, Cho, Tae-Hee, additional, Choe, Chi-un, additional, Choy, Lillian, additional, Christensen, Hanne, additional, Ciatipis, Mareva, additional, Cloud, Geoffrey, additional, Cogez, Julien, additional, Cortijo, Elisa, additional, Crozier, Sophie, additional, Damgaard, Dorte, additional, Dani, Krishna, additional, De Coene, Beatrijs, additional, De Hollander, Isabel, additional, De Keyser, Jacques, additional, De Klippel, Nina, additional, De Maeseneire, Charlotte, additional, De Smedt, Ann, additional, del Mar Castellanos Rodrigo, Maria, additional, Deltour, Sandrine, additional, Demeestere, Jelle, additional, Derex, Laurent, additional, Desfontaines, Philippe, additional, Dittrich, Ralf, additional, Dixit, Anand, additional, Dobbels, Laurens, additional, Domigo, Valérie, additional, Dorado, Laura, additional, Druart, Charlotte, additional, Dupont, Kristina Hougaard, additional, Dusart, Anne, additional, Dziewas, Rainer, additional, Ebner, Matthias, additional, Edjali-Goujon, Myriam, additional, Eisele, Philipp, additional, El Tawil, Salwa, additional, Elhfnawy, Ahmed, additional, Etexberria, Ana, additional, Evans, Nicholas, additional, Fandler, Simon, additional, Fazekas, Franz, additional, Felix, Sandra, additional, Fiebach, Jochen B., additional, Fiehler, Jens, additional, Filipov, Alexandra, additional, Filipski, Katharina, additional, Fleischmann, Robert, additional, Foerch, Christian, additional, Ford, Ian, additional, Gaenslen, Alexandra, additional, Galinovic, Ivana, additional, Gancedo, Elena Meseguer, additional, Ganeshan, Ramanan, additional, García Esperón, Carlos, additional, Garrido, Alicia, additional, Gattringer, Thomas, additional, Geraghty, Olivia, additional, Geran, Rohat, additional, Gerner, Stefan, additional, Godon-Hardy, Sylvie, additional, Göhler, Jos, additional, Golsari, Amir, additional, Gomis, Meritxell, additional, Gorriz, David, additional, Gramse, Verena, additional, Grau, Laia, additional, Griebe, Martin, additional, Guerrero, Cristina, additional, Guerzoglu, Damla, additional, Guettier, Sophie, additional, Guiraud, Vincent, additional, Gumbinger, Christoph, additional, Gunreben, Ignaz, additional, Haertig, Florian, additional, Hametner, Christian, additional, Hanseeuw, Bernard, additional, Hansen, Andreas, additional, Hansen, Jakob, additional, Harbo, Thomas, additional, Harloff, Andreas, additional, Harmel, Peter, additional, Häusler, Karl Georg, additional, Heinen, Florian, additional, Held, Valentin, additional, Hellwig, Simon, additional, Hemelsoet, Dimitri, additional, Hennerici, Michael, additional, Herm, Juliane, additional, Hermans, Sylvia, additional, Hernández, María, additional, Hervas Vicente, Jose, additional, Hjort, Niels, additional, Hobeanu, Cristina, additional, Hobohm, Carsten, additional, Höfner, Elmar, additional, Hohenbichler, Katharina, additional, Hommel, Marc, additional, Hoppe, Julia, additional, Hornberger, Eva, additional, Hoyer, Carolin, additional, Huang, Xuya, additional, Ipsen, Nils, additional, Isern, Irina, additional, Ispierto, Lourdes, additional, Iversen, Helle, additional, Jeppesen, Lise, additional, Jimenez, Marta, additional, Jungehülsing, Jan, additional, Jüttler, Eric, additional, Kalladka, Dheeraj, additional, Kallmünzer, Bernd, additional, Kar, Arindam, additional, Kellert, Lars, additional, Kemmling, André, additional, Kessler, Tobias, additional, Khan, Usman, additional, Klein, Matthias, additional, Kleinschnitz, Christoph, additional, Klockziem, Matti, additional, Knops, Michael, additional, Koehler, Luzie, additional, Koehrmann, Martin, additional, Kohlfürst, Heinz, additional, Kollmar, Rainer, additional, Kraft, Peter, additional, Krause, Thomas, additional, Kristensen, Bo, additional, Kröber, Jan M., additional, Kurka, Natalia, additional, Ladoux, Alexandre, additional, Laloux, Patrice, additional, Lamy, Catherine, additional, Landrault, Emmanuelle, additional, Lauer, Arne, additional, Lebely, Claire, additional, Leempoel, Jonathan, additional, Lees, Kennedy, additional, Leger, Anne, additional, Legrand, Laurence, additional, Li, Lin, additional, Löbbe, Anna-Mareike, additional, London, Frederic, additional, Lopez-cancio, Elena, additional, Lorenz, Matthias, additional, Louw, Stephen, additional, Lovelock, Caroline, additional, Lozano Sánchez, Manuel, additional, Lucente, Giuseppe, additional, Lückl, Janos, additional, Luna, Alain, additional, Macha, Kosmas, additional, Machet, Alexandre, additional, Mackenrodt, Daniel, additional, Madzar, Dominik, additional, Majoie, Charles, additional, Männer, Anika, additional, Maqueda, Vicky, additional, Marstrand, Jacob, additional, Martinez, Alicia, additional, Marzina, Annika, additional, Mechthouff, Laura, additional, Meden, Per, additional, Meersman, Guy, additional, Meier, Julia, additional, Mellerio, Charles, additional, Menn, Oliver, additional, Meyer, Nadja, additional, Michalski, Dominik, additional, Michels, Peter, additional, Michelsen, Lene, additional, Millán Torne, Monica, additional, Minnerup, Jens, additional, Modrau, Boris, additional, Moeller, Sebastian, additional, Møller, Anette, additional, Morel, Nathalie, additional, Moreton, Fiona, additional, Morin, Ludovic, additional, Moulin, Thierry, additional, Moynihan, Barry, additional, Mueller, Anne K., additional, Muir, Keith W., additional, Mulero, Patricia, additional, Mundiyanapurath, Sibu, additional, Mutzenbach, Johannes, additional, Nagel, Simon, additional, Naggara, Oliver, additional, Nallasivan, Arumugam, additional, Navalpotro, Irene, additional, Nave, Alexander H., additional, Nederkoorn, Paul, additional, Neeb, Lars, additional, Neugebauer, Hermann, additional, Neumann-Haefelin, Tobias, additional, Oberndorfer, Stefan, additional, Opherk, Christian, additional, Oppel, Lorenz, additional, Oppenheim, Catherine, additional, Orthgieß, Johannes, additional, Ostergaard, Leif, additional, Paindeville, Perrine, additional, Palomeras, Ernest, additional, Panitz, Verena, additional, Patel, Bhavni, additional, Peeters, Andre, additional, Peeters, Dirk, additional, Pellisé, Anna, additional, Pelz, Johann, additional, Pereira, Anthony, additional, Pérez de la Ossa, Natalia, additional, Perry, Richard, additional, Petraza, Salvador, additional, Peysson, Stéphane, additional, Pfeilschifter, Waltraud, additional, Pichler, Alexander, additional, Pierskalla, Alexandra, additional, Pledl, Hans-Werner, additional, Poli, Sven, additional, Pomrehn, Katrin, additional, Poulsen, Marika, additional, Prats, Luis, additional, Presas, Silvia, additional, Prohaska, Elisabeth, additional, Puetz, Volker, additional, Puig, Josep, additional, Puig Alcántara, Josep, additional, Purrucker, Jan, additional, Quenardelle, Veronique, additional, Ramachandran, Sankaranarayanan, additional, Raphaelle, Soulliard, additional, Raposo, Nicolas, additional, Reiff, Tilman, additional, Remmers, Michel, additional, Renou, Pauline, additional, Ribitsch, Martin, additional, Richter, Hardy, additional, Ritter, Martin, additional, Ritzenthaler, Thomas, additional, Rodier, Gilles, additional, Rodriguez-Regent, Christine, additional, Rodríguez-Yáñez, Manuel, additional, Roennefarth, Maria, additional, Roffe, Christine, additional, Rosenbaum, Sverre, additional, Rosso, Charlotte, additional, Röther, Joachim, additional, Rozanski, Michal, additional, Ruiz de Morales, Noelia, additional, Russo, Francesca, additional, Rutgers, Matthieu, additional, Sagnier, Sharmilla, additional, Samson, Yves, additional, Sánchez, Josep, additional, Sauer, Tamara, additional, Schäfer, Jan H., additional, Schieber, Simon, additional, Schill, Josef, additional, Schlak, Dennis, additional, Schlemm, Ludwig, additional, Schmidt, Sein, additional, Schonewille, Wouter, additional, Schröder, Julian, additional, Schulz, Andreas, additional, Schurig, Johannes, additional, Schwarting, Sönke, additional, Schwarz, Alexander, additional, Schwarzbach, Christopher, additional, Seidel, Matthias, additional, Seiler, Alexander, additional, Sembill, Jochen, additional, Serena Leal, Joaquin, additional, Shetty, Ashit, additional, Sibon, Igor, additional, Simonsen, Claus Z., additional, Singer, Oliver, additional, Sivagnanaratham, Aravinth, additional, Smets, Ide, additional, Smith, Craig, additional, Soors, Peter, additional, Sprigg, Nikola, additional, Spruegel, Maximilian, additional, Stark, David, additional, Steinert, Susanne, additional, Stösser, Sebastian, additional, Stuermlinger, Markus, additional, Swinnen, Bart, additional, Tamazyan, Ruben, additional, Tembl, Jose, additional, Terceno Izaga, Mikel, additional, Thomalla, Götz, additional, Touze, Emmanuel, additional, Truelsen, Thomas, additional, Turc, Guillaume, additional, Turine, Gaetane, additional, Tütüncü, Serdar, additional, Tyrell, Pippa, additional, Ustrell, Xavier, additional, Vadot, Wilfried, additional, Vallet, Anne-Evelyne, additional, Vallet, Pauline, additional, van den Berg, Lucie, additional, van den Berg, Sophie, additional, van Eendenburg, Cecile, additional, Van Hooff, Robbert-Jan, additional, van Sloten, Isabelle, additional, Vanacker, Peter, additional, Vancaester, Evelien, additional, Vanderdonckt, Patrick, additional, Vandermeeren, Yves, additional, Vanhee, Frederik, additional, Veltkamp, Roland, additional, Vestergaard, Karsten, additional, Viguier, Alain, additional, Vilas, Dolores, additional, Villringer, Kersten, additional, Voget, Dieke, additional, von Schrader, Jörg, additional, von Weitzel, Paul, additional, Warburton, Elisabeth, additional, Weber, Claudia, additional, Weber, Jörg, additional, Wegscheider, Karl, additional, Wegscheider, Mirko, additional, Weimar, Christian, additional, Weinstich, Karin, additional, Weise, Christopher, additional, Weise, Gesa, additional, Willems, Chris, additional, Winder, Klemens, additional, Wittayer, Matthias, additional, Wolf, Marc, additional, Wolf, Martin, additional, Wolff, Valerie, additional, Wollboldt, Christian, additional, Wollenweber, Frank, additional, Wouters, Anke, additional, Yalo, Bertrand, additional, Yger, Marion, additional, Younan, Nadia, additional, Yperzeele, Laetita, additional, Zegarac, Vesna, additional, Zeiner, Pia, additional, Ziemann, Ulf, additional, Zonneveld, Thomas, additional, Zuber, Mathieu, additional, Akutsu, Tsugio, additional, Aoki, Junya, additional, Arakawa, Shuji, additional, Doijiri, Ryosuke, additional, Egashira, Yusuke, additional, Enomoto, Yukiko, additional, Furui, Eisuke, additional, Furuta, Konosuke, additional, Gotoh, Seiji, additional, Hamasaki, Toshimitsu, additional, Hasegawa, Yasuhiro, additional, Hirano, Teryuki, additional, Homma, Kazunari, additional, Ichijyo, Masahiko, additional, Ide, Toshihiro, additional, Igarashi, Shuichi, additional, Iguchi, Yasuyuki, additional, Ihara, Masafumi, additional, Ikenouchi, Hajime, additional, Inoue, Tsuyoshi, additional, Itabashi, Ryo, additional, Ito, Yasuhiro, additional, Iwama, Toru, additional, Kamiyama, Kenji, additional, Kamiyoshi, Shoko, additional, Kanai, Haruka, additional, Kanematsu, Yasuhisa, additional, Kanzawa, Takao, additional, Kimura, Kazumi, additional, Kitayama, Jiro, additional, Kitazono, Takanari, additional, Kondo, Rei, additional, Kudo, Kohsuke, additional, Kusumi, Masayoshi, additional, Kuwahara, Ken, additional, Matsumoto, Shoji, additional, Matsuoka, Hideki, additional, Mihara, Ban, additional, Minematsu, Kazuo, additional, Miura, Ken, additional, Morita, Naomi, additional, Mouri, Wataru, additional, Murata, Kayo, additional, Nagakane, Yoshinari, additional, Nakase, Taizen, additional, Ohara, Hiromi, additional, Ohara, Nobuyuki, additional, Ohnishi, Hideyuki, additional, Ohta, Hajime, additional, Ohtaki, Masafumi, additional, Ohtani, Ryo, additional, Ohtsuki, Toshiho, additional, Ohyama, Hideo, additional, Okada, Takashi, additional, Okada, Yasushi, additional, Osaki, Masato, additional, Sakai, Nobuyuki, additional, Sanbongi, Yoshiki, additional, Sasaki, Naoshi, additional, Sasaki, Makoto, additional, Sato, Shoichiro, additional, Seki, Kenta, additional, Shimizu, Wataru, additional, Shiokawa, Yoshiaki, additional, Sozu, Takashi, additional, Suzuki, Junichiro, additional, Suzuki, Rieko, additional, Takagi, Yasushi, additional, Takizawa, Shunya, additional, Tanahashi, Norio, additional, Tanaka, Eijiro, additional, Tanaka, Ryota, additional, Tateishi, Yohei, additional, Terada, Tomoaki, additional, Terasaki, Tadashi, additional, Todo, Kenichi, additional, Tokunaga, Azusa, additional, Tsujino, Akira, additional, Ueda, Toshihiro, additional, Uesaka, Yoshikazu, additional, Uotani, Mihoko, additional, Urabe, Takao, additional, Watanabe, Masao, additional, Yagita, Yoshiki, additional, Yakushiji, Yusuke, additional, Yasui, Keizo, additional, Yonehara, Toshiro, additional, Yoshimura, Shinichi, additional, Aarnio, K., additional, Alemseged, F., additional, Anderson, C., additional, Ang, T., additional, Archer, M.L., additional, Attia, J., additional, Bailey, P., additional, Balabanski, A., additional, Barber, A., additional, Barber, P.A., additional, Bernhardt, J., additional, Bivard, A., additional, Blacker, D., additional, Bladin, C.F., additional, Brodtmann, A., additional, Cadilhac, D., additional, Campbell, B.C.V., additional, Carey, L., additional, Celestino, S., additional, Chan, L., additional, Chang, W.H., additional, ChangI, A., additional, Chen, C.H., additional, Chen, C.-I., additional, Chen, H.F., additional, Chen, T.C., additional, Chen, W.H., additional, Chen, Y.Y., additional, Cheng, C.A., additional, Cheong, E., additional, Chiou, Y.W., additional, Choi, P.M., additional, Chu, H.J., additional, Chuang, C.S., additional, Chung, T.C., additional, Churilov, L., additional, Clissold, B., additional, Connelly, A., additional, Coote, S., additional, Coulton, B., additional, Cowley, E., additional, Cranefield, J., additional, Curtze, S., additional, D'Este, C., additional, Davis, S.M., additional, Day, S., additional, Desmond, P.M., additional, Dewey, H.M., additional, Ding, C., additional, Donnan, G.A., additional, Drew, R., additional, Eirola, S., additional, Field, D., additional, Frost, T., additional, Garcia-Esperon, C., additional, George, K., additional, Gerraty, R., additional, Grimley, R., additional, Guo, Y.C., additional, Hankey, G., additional, Harvey, J., additional, Ho, S.C., additional, Hogan, K., additional, Howells, D., additional, Hsiao, P.M., additional, Hsu, C.H., additional, Hsu, C.T., additional, Hsu, C.-S., additional, Hsu, J.P., additional, Hsu, Y.D., additional, Hsu, Y.T., additional, Hu, C.J., additional, Huang, C.C., additional, Huang, H.Y., additional, Huang, M.Y., additional, Huang, S.C., additional, Huang, W.S., additional, Jackson, D., additional, Jeng, J.S., additional, Jiang, S.K., additional, Kaauwai, L., additional, Kasari, O., additional, King, J., additional, Kleinig, T.J., additional, Koivu, M., additional, Kolbe, J., additional, Krause, M., additional, Kuan, C.W., additional, Kung, W.L., additional, Kyndt, C., additional, Lau, C.L., additional, Lee, A., additional, Lee, C.Y., additional, Lee, J.T., additional, Lee, Y., additional, Lee, Y.C., additional, Levi, C., additional, Levi, C.R., additional, Lien, L.M., additional, Lim, J.C., additional, Lin, C.C., additional, Lin, C.H., additional, Lin, C.M., additional, Lin, D., additional, Liu, C.H., additional, Liu, J., additional, Lo, Y.C., additional, Loh, P.S., additional, Low, E., additional, Lu, C.H., additional, Lu, C.J., additional, Lu, M.K., additional, Ly, J., additional, Ma, H., additional, Macaulay, L., additional, Macdonnell, R., additional, Mackey, E., additional, Macleod, M., additional, Mahadevan, J., additional, Maxwell, V., additional, McCoy, R., additional, McDonald, A., additional, McModie, S., additional, Meretoja, A., additional, Mishra, S., additional, Mitchell, P.J., additional, Miteff, F., additional, Moore, A., additional, Muller, C., additional, Ng, F., additional, Ng, F.C., additional, Ng, J-L., additional, O'Brian, W., additional, O'Collins, V., additional, Oxley, T.J., additional, Parsons, M.W., additional, Patel, S., additional, Peng, G.S., additional, Pesavento, L., additional, Phan, T., additional, Rodrigues, E., additional, Ross, Z., additional, Sabet, A., additional, Sallaberger, M., additional, Salvaris, P., additional, Shah, D., additional, Sharma, G., additional, Sibolt, G., additional, Simpson, M., additional, Singhal, S., additional, Snow, B., additional, Spratt, N., additional, Stark, R., additional, Sturm, J., additional, Sun, M.C., additional, Sun, Y., additional, Sung, P.S., additional, Sung, Y.F., additional, Suzuki, M., additional, Tan, M., additional, Tang, S.C., additional, Tatlisumak, T., additional, Thijs, V., additional, Tiainen, M., additional, Tsai, C.H., additional, Tsai, C.K., additional, Tsai, C.L., additional, Tsai, H.T., additional, Tsai, L.K., additional, Tseng, C.H., additional, Tseng, L.T., additional, Tsoleridis, J., additional, Tu, H., additional, Tu, H.T-H., additional, Vallat, W., additional, Virta, J., additional, Wang, W.C., additional, Wang, Y.T., additional, Waters, M., additional, Weir, L., additional, Wijeratne, T., additional, Williams, C., additional, Wilson, W., additional, Wong, A.A., additional, Wong, K., additional, Wu, T.Y., additional, Wu, Y.H., additional, Yan, B., additional, Yang, F.C., additional, Yang, Y.W., additional, Yassi, N., additional, Yeh, H.L., additional, Yeh, J.H., additional, Yeh, S.J., additional, Yen, C.H., additional, Young, D., additional, Ysai, C.L., additional, Zhang, W.W., additional, Zhao, H., additional, Zhao, L., additional, Althaus-Knaurer, Katharina, additional, Berrouschot, Jörg, additional, Bluhmki, Erich, additional, Bovi, Paolo, additional, Chatellier, Gilles, additional, Cove, Lynda, additional, Davis, Stephen, additional, Dixit, A., additional, Donnan, Geoffrey, additional, Ehrenkrona, Christina, additional, Eschenfelder, Christoph, additional, Fatar, Marc, additional, Francisco Arenillas, Juan, additional, Gruber, Franz, additional, Kala, Lalit, additional, Kapeller, Peter, additional, Kaste, Markku, additional, Kessler, Christof, additional, Köhrmann, Martin, additional, Laage, Rico, additional, Lees, Kennedy R., additional, Luna Rodriguez, Alain, additional, Mas, Jean-Louis, additional, Mikulik, Robert, additional, Molina, Carlos, additional, Muddegowda, Girish, additional, Muir, Keith, additional, Niederkorn, Kurt, additional, Nuñez, Xavier, additional, Schellinger, Peter, additional, Serena, Joaquin, additional, Sobesky, Jan, additional, Steiner, Thorsten, additional, Svenson, Ann-Sofie, additional, von Kummer, Rüdiger, additional, Wardlaw, Joanna, additional, Betensky, Rebecca A., additional, Boulouis, Gregoire, additional, Carandang, Raphael A., additional, Copen, William A., additional, Cougo, Pedro, additional, Cutting, Shawna, additional, Drake, Kendra, additional, Ford, Andria L., additional, Hallenbeck, John, additional, Harris, Gordon J., additional, Hoesch, Robert, additional, Hsia, Amie, additional, Kase, Carlos, additional, Latour, Lawrence, additional, Lev, Michael H., additional, Muzikansky, Alona, additional, Nagaraja, Nandakumar, additional, Schwamm, Lee H., additional, Searls, Eric, additional, Song, Shlee S., additional, Starkman, Sidney, additional, Yoo, Albert J., additional, and Zand, Ramin, additional
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- 2020
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56. Olfaction in LRRK2 Linked Parkinson’s Disease: Is It Different from Idiopathic Parkinson’s Disease?
- Author
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Vilas, Dolores, primary, Tolosa, Eduard, additional, Quintana, María, additional, Pont-Sunyer, Claustre, additional, Santos, Meritxell, additional, Casellas, Aina, additional, Valldeoriola, Francesc, additional, Compta, Yaroslau, additional, Martí, María José, additional, and Mullol, Joaquim, additional
- Published
- 2020
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57. Overlapping neuropathological findings in an asymptomatic SPAST gene mutation carrier
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Forcén, Sara, primary, Cuevas, Ane Miren Crespo, additional, Aldecoa, Iban, additional, Ramos, Oscar, additional, Ispierto, Lourdes, additional, Álvarez, Ramiro, additional, and Vilas, Dolores, additional
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- 2020
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- View/download PDF
58. Alpha-Synuclein Pathology in the Submandibular Gland of LRRK2 p.G2019S Mutation Carriers.
- Author
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Vilas, Dolores, primary, Tolosa, Eduardo, additional, Aldecoa, Iban, additional, Berenguer, Joan, additional, Vilaseca, Isabel, additional, Iranzo, Alex, additional, Marti, Maria J., additional, Martí, Carles, additional, Lomeña, Francisco, additional, Alós, Llucia, additional, and Gelpi, Ellen, additional
- Published
- 2020
- Full Text
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59. Platelet miRNA bio-signature discriminates between dementia with Lewy bodies and Alzheimer disease: A cross-sectional study.
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Gámez-Valero, Ana, primary, Campdelacreu, Jaume, additional, Vilas, Dolores, additional, Ispierto, Lourdes, additional, Samaniego, Daniela, additional, Gascón-Bayarri, Jordi, additional, Reñé, Ramón, additional, Álvarez, Ramiro, additional, Armengol, Maria P, additional, Borràs, Francesc E., additional, and Beyer, Katrin, additional
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- 2020
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60. Platelet miRNA bio-signature discriminates between dementia with Lewy bodies and Alzheimer disease
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Gámez-Valero, Ana, primary, Campdelacreu, Jaume, additional, Vilas, Dolores, additional, Ispierto, Lourdes, additional, Samaniego, Daniela, additional, Gascón-Bayarri, Jordi, additional, Reñé, Ramón, additional, Álvarez, Ramiro, additional, Armengol, Maria P, additional, Borràs, Francesc E., additional, and Beyer, Katrin, additional
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- 2020
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61. Third Ventricle Width Assessed by Transcranial Sonography as Predictor of Long-Term Cognitive Impairment
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Crespo-Cuevas, Ane Miren, primary, López-Cancio, Elena, additional, Cáceres, Cynthia, additional, González, Anna, additional, Ispierto, Lourdes, additional, Hernández-Pérez, María, additional, Mataró, María, additional, Planas, Anna, additional, Canento, Tamara, additional, Martín, Lorena, additional, Arenillas, Juan Francisco, additional, Alvarez, Ramiro, additional, and Vilas, Dolores, additional
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- 2020
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62. alpha-synuclein RT-QuIC in cerebrospinal fluid of LRRK2-linked Parkinson's disease
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Garrido, Alicia, Fairfoul, Graham, Tolosa, Eduardo S., Jose Marti, Maria, Green, Alison, Compta, Yaroslau, Valldeoriola, Francesc, Munoz, Esteban, Fernandez, Manel, Alvarez, Ramiro, Vilas, Dolores, Ispierto, Lourdes, De Fabregues, Oriol, Hernandez-Vara, Jorge, Puente, Victor, Calopa, Matilde, Jauma, Serge, Campdelacreu, Jaume, Bayes, Angels, Avila, Asuncion, Caballol, Nuria, Aguilar, Miguel, Casquero, Pilar, and Barcelona LRRK2 Study Grp
- Subjects
0301 basic medicine ,Parkinson's disease ,humanos ,Disease ,Gastroenterology ,0302 clinical medicine ,Cerebrospinal fluid ,Protein kinases ,Malaltia de Parkinson ,Research Articles ,mediana edad ,Cerebrospinal Fluid ,anciano ,General Neuroscience ,Parkinsonism ,Parkinson Disease ,Middle Aged ,adulto ,LRRK2 ,alpha-Synuclein ,Research Article ,RC321-571 ,Adult ,medicine.medical_specialty ,alfa-sinucleína ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Neuropathology ,03 medical and health sciences ,In vivo ,Internal medicine ,medicine ,Humans ,RC346-429 ,mutación ,Aged ,enfermedad de Parkinson ,business.industry ,Líquid cefalorraquidi ,medicine.disease ,nervous system diseases ,Proteïnes quinases ,líquido cefalorraquídeo ,030104 developmental biology ,Mutation ,Histopathology ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background Leucine‐rich kinase 2 (LRRK2)‐linked Parkinson's disease (PD) is clinically indistinguishable from idiopathic PD (IPD). A pleiotropic neuropathology has been recognized but the majority of studies in LRRK2 p.G2019S patients reveal Lewy‐type synucleinopathy as its principal histological substrate. To date no in vivo biomarkers of synucleinopathy have been found in LRRK2 mutation carriers. Objectives We used real‐time quaking‐induced conversion (RT‐QuIC) technique to assess the presence of alpha‐synuclein (a‐syn) aggregates in cerebrospinal fluid (CSF) of LRRK2 p.G2019S carriers. Methods CSF samples of 51 subjects were analyzed: 15 LRRK2 p.G2019S PD, 10 IPD, 16 LRRK2 p.G2019S nonmanifesting carriers (NMC) and 10 healthy controls. The presence of parkinsonism and prodromal symptoms was assessed in all study subjects. Results Forty percent (n = 6) LRRK2‐PD, and 18.8% (n = 3) LRRK2‐NMC had a positive a‐syn RT‐QuIC response. RT‐QuIC detected IPD with 90% sensitivity and 80% specificity. No clinical differences were detected between LRRK2‐PD patients with positive and negative RT‐QuIC. A positive RT‐QuIC result in LRRK2‐NMC occurred in a higher proportion of subjects meeting the Movement Disorder Society research criteria for prodromal PD. Interpretation RT‐QuIC detects a‐syn aggregation in CSF in a significant number of patients with LRRK2‐PD, but less frequently than in IPD. A small percentage of LRRK2‐NMC tested also positive. If appropriately validated in long‐term studies with large number of mutation carriers, and hopefully, postmortem or in vivo confirmation of histopathology, RT‐QuIC could contribute to the selection of candidates to receive disease modifying drugs, in particular treatments targeting a‐syn deposition.
- Published
- 2019
63. Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood
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Pérez-Roca, Laia, Adame Castillo, Cristina, Campdelacreu, Jaume, Ispierto, Lourdes, Vilas, Dolores, Rene, Ramon, Alvarez, Ramiro, Gascon-Bayarri, Jordi, Serrano-Munoz, Maria A., Ariza Fernández, A.., Beyer, Katrin, and Universitat Autònoma de Barcelona
- Subjects
0301 basic medicine ,Micro RNAs ,Pathology ,medicine.medical_specialty ,Parkinson's disease ,transcript variants ,Dementia with Lewy bodies ,Caudate nucleus ,Disease ,Orginal Article ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Transcript variants ,Malaltia de Parkinson ,mental disorders ,medicine ,GBA mRNA expression ,Glucocerebrosidase deficiency ,Diminution ,Temporal cortex ,glucocerebrosidase deficiency ,Lewy body ,business.industry ,Demència amb cossos de Lewy ,Cell Biology ,medicine.disease ,nervous system diseases ,MicroRNAs ,030104 developmental biology ,Parkinson’s disease ,Neurology (clinical) ,Lewy body dementia ,Geriatrics and Gerontology ,dementia with Lewy bodies ,business ,Glucocerebrosidase ,030217 neurology & neurosurgery - Abstract
Altres ajuts: This work was supported by the Marató TV3 grant 1405/10. Altres ajuts: MSCBS/PI12-1702 Altres ajuts: MSCBS/PI15-216 Parkinson disease (PD) and dementia with Lewy bodies (DLB) are Lewy body diseases characterized by abnormal alpha-synuclein deposits and overlapping pathological features in the brain. Several studies have shown that glucocerebrosidase (GBA) deficiency is involved in the development of LB diseases. Here, we aimed to find out if this deficiency starts at the transcriptional level, also involves alternative splicing, and if GBA expression changes in brain are also detectable in blood of patients with LB diseases. The expression of three GBA transcript variants (GBAtv1, GBAtv2 and GBAtv5) was analyzed in samples from 20 DLB, 25 PD and 17 control brains and in blood of 20 DLB, 26 PD patients and 17 unaffected individuals. Relative mRNA expression was determined by real-time PCR. Expression changes were evaluated by the ΔΔCt method. In brain, specific expression profiles were identified in the temporal cortex of DLB and in the caudate nucleus of PD. In blood, significant GBA mRNA diminution was found in both DLB and PD patients. Early PD and early-onset DLB patients showed lowest GBA levels which were normal in PD patients with advanced disease and DLB patients who developed disease after 70 years of age. In conclusion, disease group specific GBA expression profiles were found in mostly affected areas of LBD. In blood, GBA expression was diminished in LB diseases, especially in patients with early onset DLB and in patients with early PD. Age of disease onset exerts an opposite effect on GBA expression in DLB and PD.
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- 2018
64. High mitochondrial DNA in cerebrospinal fluid is associated with LRRK2-related Parkinson's disease
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Podlesniy, Petar, Vilas, Dolores, Taylor, Peggy, Shaw, Leslie M., Tolosa, Eduardo, and Trullas, Ramón
- Abstract
Trabajo presentado en el XI CIBERNED Scientific Forum. Alzheimer's Global Summit, celebrado en Lisboa, del 18 al 22 de septiembre de 2017
- Published
- 2017
65. Mitochondrial DNA in cerebrospinal fluid distinguishes idiopathic from LRRK2-related Parkinson's disease
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Podlesniy, Petar, Vilas, Dolores, Taylor, Peggy, Shaw, Leslie M., Tolosa, Eduardo, and Trullas, Ramón
- Abstract
Trabajo presentado en el 17th National Congress of the Spanish Society of Neuroscience, celebrado en Alicante, del 27 al 30 de septiembre de 2017
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- 2017
66. Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry
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Lee, Annie J, Wang, Yuanjia, Tolosa, Eduardo, Pont-Sunyer, Claustre, Vilas, Dolores, Schüle, Birgitt, Kausar, Farah, Foroud, Tatiana, Berg, Daniela, Brockmann, Kathrin, Goldwurm, Stefano, Siri, Chiara, Alcalay, Roy N, Asselta, Rosanna, Ruiz-Martinez, Javier, Mondragón, Elisabet, Marras, Connie, Ghate, Taneera, Giladi, Nir, Mirelman, Anat, Marder, Karen, Fox LRRK2 Cohort Consortium, Michael J., Mejia-Santana, Helen, Saunders-Pullman, Rachel, Bressman, Susan, Corvol, Jean-Christophe, Brice, Alexis, Lesage, Suzanne, and Mangone, Graziella
- Subjects
Adult ,Male ,genetics [Jews] ,Glycine ,genetics [Mutation] ,Penetrance ,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ,Article ,Cohort Studies ,Gene Frequency ,genetics [Parkinson Disease] ,Serine ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,genetics [Glycine] ,Genetic Testing ,genetics [Genetic Predisposition to Disease] ,Aged ,Aged, 80 and over ,Family Health ,genetics [Serine] ,Parkinson Disease ,Middle Aged ,Jews ,Mutation ,genetics [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2] ,Female ,ethnology [Parkinson Disease] - Abstract
Penetrance estimates of the leucine-rich repeat kinase 2 (LRRK2) p.G2019S mutation for PD vary widely (24%-100%). The p.G2019S penetrance in individuals of Ashkenazi Jewish ancestry has been estimated as 25%, adjusted for multiple covariates. It is unknown whether penetrance varies among different ethnic groups. The objective of this study was to estimate the penetrance of p.G2019S in individuals of non-Ashkenazi Jewish ancestry and compare penetrance between Ashkenazi Jews and non-Ashkenazi Jews to age 80.The kin-cohort method was used to estimate penetrance in 474 first-degree relatives of 69 non-Ashkenazi Jewish LRRK2 p.G2019S carrier probands at 8 sites from the Michael J. Fox LRRK2 Cohort Consortium. An identical validated family history interview was administered to assess age at onset of PD, current age, or age at death for relatives in different ethnic groups at each site. Neurological examination and LRRK2 genotype of relatives were included when available.Risk of PD in non-Ashkenazi Jewish relatives who carry a LRRK2 p.G2019S mutation was 42.5% (95% confidence interval [CI]: 26.3%-65.8%) to age 80, which is not significantly higher than the previously estimated 25% (95% CI: 16.7%-34.2%) in Ashkenazi Jewish carrier relatives. The penetrance of PD to age 80 in LRRK2 p.G2019S mutation carrier relatives was significantly higher than the noncarrier relatives, as seen in Ashkenazi Jewish relatives.The similar penetrance of LRRK2 p.G2019S estimated in Ashkenazi Jewish carriers and non-Ashkenazi Jewish carriers confirms that p.G2019S penetrance is 25% to 42.5% at age 80 in all populations analyzed. © 2017 International Parkinson and Movement Disorder Society.
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- 2016
67. Lack of central and peripheral nervous system synuclein pathology in R1441G LRRK2-associated Parkinson’s disease
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Vilas, Dolores, primary, Gelpi, Ellen, additional, Aldecoa, Iban, additional, Grau, Oriol, additional, Rodriguez-Diehl, Roberta, additional, Jaumà, Serge, additional, Martí, María José, additional, and Tolosa, Eduard, additional
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- 2018
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68. Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder
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Stokholm, Morten Gersel, primary, Iranzo, Alex, additional, Østergaard, Karen, additional, Serradell, Mónica, additional, Otto, Marit, additional, Bacher Svendsen, Kristina, additional, Garrido, Alicia, additional, Vilas, Dolores, additional, Parbo, Peter, additional, Borghammer, Per, additional, Santamaria, Joan, additional, Møller, Arne, additional, Gaig, Carles, additional, Brooks, David J., additional, Tolosa, Eduardo, additional, and Pavese, Nicola, additional
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- 2018
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69. Distinctive Olfactory Pattern in Parkinson’s Disease and Non-Neurodegenerative Causes of Hyposmia
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Crespo Cuevas, Ane Miren, primary, Ispierto, Lourdes, additional, Vilas, Dolores, additional, Planas, Anna, additional, Planas, Albert, additional, Isern, Irina, additional, Sanchez, Josep, additional, De Haro, Josep, additional, and Alvarez, Ramiro, additional
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- 2018
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70. Method for the sub-classification of patients suffering from parkinson disease
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Trullas, Ramón, Podlesniy, Petar, Vilas, Dolores, Tolosa, Eduardo, Trullas, Ramón, Podlesniy, Petar, Vilas, Dolores, and Tolosa, Eduardo
- Abstract
The invention relates to the use of extracellular mitochondrial DNA as a quantitative biomarker for the sub-classification of patients suffering from Parkinson disease in the subgroups of familial or idiopathic Parkinson. The invention also relates to a method and to a kit for the sub-classification of patients suffering from Parkinson disease using said biomarker.
- Published
- 2017
71. Clinical and neuropathological features of progressive supranuclear palsy in Leucine rich repeat kinase ( LRRK2 ) G2019S mutation carriers
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Vilas, Dolores, primary, Sharp, Madeleine, additional, Gelpi, Ellen, additional, Genís, David, additional, Marder, Karen S., additional, Cortes, Etty, additional, Vonsattel, Jean‐Paul, additional, Tolosa, Eduard, additional, and Alcalay, Roy N., additional
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- 2017
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72. Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study
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Stokholm, Morten Gersel, primary, Iranzo, Alex, additional, Østergaard, Karen, additional, Serradell, Mónica, additional, Otto, Marit, additional, Svendsen, Kristina Bacher, additional, Garrido, Alicia, additional, Vilas, Dolores, additional, Borghammer, Per, additional, Santamaria, Joan, additional, Møller, Arne, additional, Gaig, Carles, additional, Brooks, David J, additional, Tolosa, Eduardo, additional, and Pavese, Nicola, additional
- Published
- 2017
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73. A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson’s Disease
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Vilas, Dolores, primary, Fernández-Santiago, Rubén, additional, Sanchez, Elena, additional, Azcona, Luis J., additional, Santos-Montes, Meritxell, additional, Casquero, Pilar, additional, Argandoña, Lucía, additional, Tolosa, Eduardo, additional, and Paisán-Ruiz, Coro, additional
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- 2017
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74. Method for the sub-classification of patients suffering from parkinson disease
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Trullas, Ramón, Podlesniy, Petar, Vilas, Dolores, and Tolosa, Eduardo
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humanities ,nervous system diseases - Abstract
The invention relates to the use of extracellular mitochondrial DNA as a quantitative biomarker for the sub-classification of patients suffering from Parkinson disease in the subgroups of familial or idiopathic Parkinson. The invention also relates to a method and to a kit for the sub-classification of patients suffering from Parkinson disease using said biomarker., Consejo Superior de Investigaciones Científicas (España), Centro de Investigación Biomédica en Ren de Enfermedades Neurodegenerativas (CIBERNED), Fundacio Clinic Per a la Recerca Biomedica, Hospital Clinic de Barcelona, Universitat de Barcelona, A1 Solicitud de patente con informe sobre el estado de la técnica
- Published
- 2015
75. Olfaction in LRRK2Linked Parkinson’s Disease: Is It Different from Idiopathic Parkinson’s Disease?
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Vilas, Dolores, Tolosa, Eduard, Quintana, María, Pont-Sunyer, Claustre, Santos, Meritxell, Casellas, Aina, Valldeoriola, Francesc, Compta, Yaroslau, Martí, María José, and Mullol, Joaquim
- Abstract
Studies on olfaction in LRRK2-associated Parkinson’s disease (LRRK2-PD) have yielded variable results. The impact of smell dysfunction upon daily life activities have been rarely assessed in PD. To characterize the olfactory deficit in LRRK2-PD and its impact on daily life activities. Twenty-four LRRK2-PD, 40 idiopathic PD (IPD), and 49 age-sex-matched controls were interviewed about olfactory characteristics and the impact of smell on daily life activities. The Barcelona Smell Identification test (BAST-24) and the Spanish-version of the 40-item University of Pennsylvania smell test (UPSIT) were applied. Nineteen (79.2%) LRRK2-PD patients reported subjective smell impairment with a low impact upon daily living activities. UPSIT score was higher in LRRK2-PD than in IPD (22.54±7.98 vs 18.84±6.03; p = 0.042). All IPD and 95.8% LRRK2-PD patients had hyposmia/anosmia, assessed by means of the UPSIT. No differences were found between LRRK2-PD and IPD regarding smell detection, memory or forced-choice identification. Most LRRK2-PD patients reported subjective smell impairment and presented hyposmia, according to validated smell tests, with a low impact of the smell dysfunction on daily life activities.
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- 2020
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76. Co-morbid demyelinating lesions and atypical clinical features in a patient with Parkinson's disease.
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Vilas, Dolores, Bargalló, Nuria, Tolosa, Eduardo, Gelpi, Ellen, and Rodriguez-Diehl, Roberta
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PARKINSON'S disease , *DYSKINESIAS , *PROGRESSIVE supranuclear palsy , *PARKINSONIAN disorders , *MULTIPLE system atrophy , *BEHAVIOR disorders , *LEWY body dementia - Abstract
Highlights from the article: As advanced age is one of the few risk factors for PD, with longer life expectancy MS patients could be at risk of developing PD [[3]]. First, an acute reversible parkinsonism could appear in a patient with relapsing-remitting MS secondary to a new demyelinating lesion in a strategic location (globus pallidus, thalamus, substania nigra and nucleus ruber), often steroid-responsive. However, no such lesions were observed in our patient and clinical evolution did not support RR-MS. Second, a gradual and progressive parkinsonism could represent one symptom of primary or secondary progressive MS involving the basal ganglia, but this was also not observed at postmortem investigation. However, MS-type plaques may have influenced the severity of the patient's PD symptoms, the poor response to antiparkinsonian drugs (anticholinergic, l-Dopa, rasagiline), and also other atypical symptoms, such as pyramidal signs and the early urinary incontinence [[3]].
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- 2019
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77. Michael J. Fox Foundation Consortium: Geographical Differences in Returning Genetic Research Data to Study Participants
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Alcalay, Roy N., Aasly, Jan, Berg, Daniela, Bressman, Susan, Brice, Alexis, Brockmann, Kathrin, Chan, Piu, Clark, Lorraine, Corvol, Jean-Christophe, Durr, Alexandra, Farrer, Matthew, Foroud, Tatiana M., Gasser, Thomas, Giladi, Nir, Halter, Cheryl, Hentati, Fayçal, Lang, Anthony, Langston, J. William, Marder, Karen, Marras, Connie, Marti-Masso, Jose-Felix, Martinez, Javier Ruiz, Mejia-Santana, Helen, Mirelman, Anat, Pont, Claustre, Orr-Urtreger, Avi, Raymond, Deborah, Saunders-Pullman, Rachel, Schüle, Birgitt, Tanner, Caroline, Tolosa, Eduardo, Vilas, Dolores, Wise, Adina, and Facheris, Maurizio
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Genetic Research ,Patient Access to Records ,Humans ,Parkinson Disease ,Protein Serine-Threonine Kinases ,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ,Article ,Foundations - Published
- 2014
78. Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease
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Podlesniy, Petar, primary, Vilas, Dolores, additional, Taylor, Peggy, additional, Shaw, Leslie M., additional, Tolosa, Eduard, additional, and Trullas, Ramon, additional
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- 2016
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79. Arm swing as a potential new prodromal marker of Parkinson's disease
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Mirelman, Anat, primary, Bernad‐Elazari, Hagar, additional, Thaler, Avner, additional, Giladi‐Yacobi, Eytan, additional, Gurevich, Tanya, additional, Gana‐Weisz, Mali, additional, Saunders‐Pullman, Rachel, additional, Raymond, Deborah, additional, Doan, Nancy, additional, Bressman, Susan B., additional, Marder, Karen S., additional, Alcalay, Roy N., additional, Rao, Ashwini K., additional, Berg, Daniela, additional, Brockmann, Kathrin, additional, Aasly, Jan, additional, Waro, Bjørg Johanne, additional, Tolosa, Eduardo, additional, Vilas, Dolores, additional, Pont‐Sunyer, Claustre, additional, Orr‐Urtreger, Avi, additional, Hausdorff, Jeffrey M., additional, and Giladi, Nir, additional
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- 2016
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80. Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study
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Vilas, Dolores, primary, Iranzo, Alex, additional, Tolosa, Eduardo, additional, Aldecoa, Iban, additional, Berenguer, Joan, additional, Vilaseca, Isabel, additional, Martí, Carles, additional, Serradell, Mónica, additional, Lomeña, Francisco, additional, Alós, Llucia, additional, Gaig, Carles, additional, Santamaria, Joan, additional, and Gelpi, Ellen, additional
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- 2016
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81. Inflammatory profile in LRRK2-associated prodromal and clinical PD
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Brockmann, Kathrin, primary, Apel, Anja, additional, Schulte, Claudia, additional, Schneiderhan-Marra, Nicole, additional, Pont-Sunyer, Claustre, additional, Vilas, Dolores, additional, Ruiz-Martinez, Javier, additional, Langkamp, Markus, additional, Corvol, Jean-Christophe, additional, Cormier, Florence, additional, Knorpp, Thomas, additional, Joos, Thomas O., additional, Gasser, Thomas, additional, Schüle, Birgitt, additional, Aasly, Jan O., additional, Foroud, Tatiana, additional, Marti-Masso, Jose Felix, additional, Brice, Alexis, additional, Tolosa, Eduardo, additional, Marras, Connie, additional, Berg, Daniela, additional, and Maetzler, Walter, additional
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- 2016
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82. Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder
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Sprenger, Fabienne S., primary, Stefanova, Nadia, additional, Gelpi, Ellen, additional, Seppi, Klaus, additional, Navarro-Otano, Judith, additional, Offner, Felix, additional, Vilas, Dolores, additional, Valldeoriola, Francesc, additional, Pont-Sunyer, Claustre, additional, Aldecoa, Iban, additional, Gaig, Carles, additional, Gines, Angels, additional, Cuatrecasas, Miriam, additional, Högl, Birgit, additional, Frauscher, Birgit, additional, Iranzo, Alex, additional, Wenning, Gregor K., additional, Vogel, Wolfgang, additional, Tolosa, Eduardo, additional, and Poewe, Werner, additional
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- 2015
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83. Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers
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Pont-Sunyer, Claustre, primary, Iranzo, Alex, additional, Gaig, Carles, additional, Fernández-Arcos, Ana, additional, Vilas, Dolores, additional, Valldeoriola, Francesc, additional, Compta, Yaroslau, additional, Fernández-Santiago, Ruben, additional, Fernández, Manel, additional, Bayés, Angels, additional, Calopa, Matilde, additional, Casquero, Pilar, additional, de Fàbregues, Oriol, additional, Jaumà, Serge, additional, Puente, Victor, additional, Salamero, Manel, additional, José Martí, Maria, additional, Santamaría, Joan, additional, and Tolosa, Eduard, additional
- Published
- 2015
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84. Nigral and striatal connectivity alterations in asymptomatic LRRK2 mutation carriers: A magnetic resonance imaging study.
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Vilas, Dolores, Segura, Bàrbara, Baggio, Hugo C., Pont‐Sunyer, Claustre, Compta, Yaroslau, Valldeoriola, Francesc, José Martí, María, Quintana, María, Bayés, Angels, Hernández‐Vara, Jorge, Calopa, Matilde, Aguilar, Miquel, Junqué, Carme, and Tolosa, Eduardo
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BASAL ganglia , *BRAIN mapping , *BRAIN stem , *CEREBRAL cortex , *MAGNETIC resonance imaging , *GENETIC mutation , *PARKINSON'S disease , *NUCLEAR families , *EARLY diagnosis - Abstract
Background: The study of functional connectivity by means of magnetic resonance imaging (MRI) in asymptomatic LRRK2 mutation carriers could contribute to the characterization of the prediagnostic phase of LRRK2-associated Parkinson's disease (PD). The objective of this study was to characterize MRI functional patterns during the resting state in asymptomatic LRRK2 mutation carriers.Methods: We acquired structural and functional MRI data of 18 asymptomatic LRRK2 mutation carriers and 18 asymptomatic LRRK2 mutation noncarriers, all first-degree relatives of LRRK2-PD patients. Starting from resting-state data, we analyzed the functional connectivity of the striatocortical and the nigrocortical circuitry. Structural brain data were analyzed by voxel-based morphometry, cortical thickness, and volumetric measures.Results: Asymptomatic LRRK2 mutation carriers had functional connectivity reductions between the caudal motor part of the left striatum and the ipsilateral precuneus and superior parietal lobe. Connectivity in these regions correlated with subcortical gray-matter volumes in mutation carriers. Asymptomatic carriers also showed increased connectivity between the right substantia nigra and bilateral occipital cortical regions (occipital pole and cuneus bilaterally and right lateral occipital cortex). No intergroup differences in structural MRI measures were found. In LRRK2 mutation carriers, age and functional connectivity correlated negatively with striatal volumes. Additional analyses including only subjects with the G2019S mutation revealed similar findings.Conclusions: Asymptomatic LRRK2 mutation carriers showed functional connectivity changes in striatocortical and nigrocortical circuits compared with noncarriers. These findings support the concept that altered brain connectivity precedes the onset of classical motor features in a genetic form of PD. © 2016 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]- Published
- 2016
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85. Nonmotor Symptoms in LRRK2 G2019S Associated Parkinson’s Disease
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Gaig, Carles, primary, Vilas, Dolores, additional, Infante, Jon, additional, Sierra, María, additional, García-Gorostiaga, Inés, additional, Buongiorno, Mariateresa, additional, Ezquerra, Mario, additional, Martí, Maria José, additional, Valldeoriola, Francesc, additional, Aguilar, Miquel, additional, Calopa, Matilde, additional, Hernandez-Vara, Jorge, additional, and Tolosa, Eduardo, additional
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- 2014
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86. Michael J. Fox Foundation LRRK2 Consortium: geographical differences in returning genetic research data to study participants
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Alcalay, Roy N., primary, Aasly, Jan, additional, Berg, Daniela, additional, Bressman, Susan, additional, Brice, Alexis, additional, Brockmann, Kathrin, additional, Chan, Piu, additional, Clark, Lorraine, additional, Cormier, Florence, additional, Corvol, Jean-Christophe, additional, Durr, Alexandra, additional, Facheris, Maurizio, additional, Farrer, Matthew, additional, Foroud, Tatiana M., additional, Gasser, Thomas, additional, Giladi, Nir, additional, Halter, Cheryl, additional, Lang, Anthony, additional, Langston, J. William, additional, Marras, Connie, additional, Marti-Masso, Jose-Felix, additional, Ruiz Martinez, Javier, additional, Mejia-Santana, Helen, additional, Mirelman, Anat, additional, Pont-Sunyer, Claustre, additional, Orr-Urtreger, Avi, additional, Raymond, Deborah, additional, Saunders-Pullman, Rachel, additional, Schüle, Birgitt, additional, Tanner, Caroline, additional, Tolosa, Eduardo, additional, Urkowitz, Alison, additional, Vilas, Dolores, additional, Wise, Adina, additional, and Marder, Karen, additional
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- 2014
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87. Identification of blood serum micro‐RNAs associated with idiopathic and LRRK2 Parkinson's disease
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Botta‐Orfila, Teresa, primary, Morató, Xavier, additional, Compta, Yaroslau, additional, Lozano, Juan José, additional, Falgàs, Neus, additional, Valldeoriola, Francesc, additional, Pont‐Sunyer, Claustre, additional, Vilas, Dolores, additional, Mengual, Lourdes, additional, Fernández, Manel, additional, Molinuevo, José Luis, additional, Antonell, Anna, additional, Martí, Maria José, additional, Fernández‐Santiago, Rubén, additional, and Ezquerra, Mario, additional
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- 2014
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88. Circadian Rhythms in the Efficacy of Intravenous Alteplase in Patients With Acute Ischemic Stroke and Middle Cerebral Artery Occlusion
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Vilas, Dolores, primary, Gomis, Meritxell, additional, Blanco, Miguel, additional, Cortés, Jordi, additional, Millán, Mònica, additional, Ossa, Natalia Pérez de la, additional, Dorado, Laura, additional, López-Cancio, Elena, additional, Suñol, Anna, additional, and Dávalos, Antoni, additional
- Published
- 2012
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89. A Novel p.Glu298Lys Mutation in the ACMSDGene in Sporadic Parkinson’s Disease
- Author
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Vilas, Dolores, Fernández-Santiago, Rubén, Sanchez, Elena, Azcona, Luis J., Santos-Montes, Meritxell, Casquero, Pilar, Argandoña, Lucía, Tolosa, Eduardo, and Paisán-Ruiz, Coro
- Abstract
Common genetic variability in the ACMSDgene has been associated with increased risk for Parkinson’s disease (PD) but ACMSDmutations in clinical cases of PD have so far not been reported. To describe a case of sporadic PD carrying a novel ACMSDmutation. As part of a genetic study to identify potential pathogenic gene defects related to PD in the Mediterranean island Menorca, an initial group of 62 PD patients underwent mutational screening using a panel-based sequencing approach. We report a 74-years-old man with sporadic PD who developed tremor in his right hand and slowness. On examination, moderate rigidity, asymmetric bradykinesia, and bilateral action tremor were present. He was started on levodopa with significant improvement. Two years later, he developed wearing off phenomena. The genetic study in the patient identified a novel ACMSDmutation resulting in p.Glu298Lys amino-acid change which was not present in neurologically normal population. Our data suggest that not only common genetic variability but also rare variants in ACMSDalone or in combination with other risk factors might increase the risk of PD.
- Published
- 2017
- Full Text
- View/download PDF
90. Patterns of care and outcome for patients with glioblastoma diagnosed during 2008–2010 in Spain.
- Author
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Graus, Francesc, Bruna, Jordi, Pardo, Javier, Escudero, Domingo, Vilas, Dolores, Barceló, Inés, Brell, Marta, Pascual, Carmen, Crespo, José A., Erro, Elena, García-Romero, Juan C., Estela, Jordi, Martino, Juan, García-Castaño, Almudena, Mata, Elena, Lema, Manuela, Gelabert, Miguel, Fuentes, Rafel, Pérez, Pedro, and Manzano, Arancha
- Published
- 2013
- Full Text
- View/download PDF
91. Dystonic head tremor secondary to neurocysticercosis
- Author
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Puig, Isabel, Gea, Mireia, Núñez, Fidel, Ispierto, Lourdes, Grau-López, Laia, Roure, Silvia, Lozano, Manuel, Lucente, Giuseppe, and Vilas, Dolores
- Published
- 2022
- Full Text
- View/download PDF
92. Lack of central and peripheral nervous system synuclein pathology in R1441G -associated Parkinson's disease.
- Author
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Vilas, Dolores, Gelpi, Ellen, Aldecoa, Iban, Grau, Oriol, Rodriguez-Diehl, Roberta, Jaumà, Serge, Martí, María José, and Tolosa, Eduard
- Subjects
PERIPHERAL nervous system ,CENTRAL nervous system ,PARKINSON'S disease ,PATHOLOGY ,AUTONOMIC nervous system ,SMELL - Published
- 2019
- Full Text
- View/download PDF
93. Lack of central and peripheral nervous system synuclein pathology in R1441G LRRK2-associated Parkinson’s disease
- Author
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Vilas, Dolores, Gelpi, Ellen, Aldecoa, Iban, Grau, Oriol, Rodriguez-Diehl, Roberta, Jaumà, Serge, Martí, María José, and Tolosa, Eduard
- Published
- 2019
- Full Text
- View/download PDF
94. Additional file 1: Table S1. of Inflammatory profile in LRRK2-associated prodromal and clinical PD
- Author
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Brockmann, Kathrin, Apel, Anja, Schulte, Claudia, Schneiderhan-Marra, Nicole, Claustre Pont-Sunyer, Vilas, Dolores, Ruiz-Martinez, Javier, Langkamp, Markus, Jean-Christophe Corvol, Cormier, Florence, Knorpp, Thomas, Joos, Thomas, Gasser, Thomas, SchĂźle, Birgitt, Aasly, Jan, Foroud, Tatiana, Marti-Masso, Jose, Brice, Alexis, Tolosa, Eduardo, Marras, Connie, Berg, Daniela, and Maetzler, Walter
- Subjects
3. Good health - Abstract
Overview of frequency of each LRRK2 mutation in the respective cohorts. Table S2. Overview of results from multivariate linear regression analyses stratified by cohort to illustrate independent associations between gender, age, disease duration, regular intake of anti-inflammatory medication, and clinical characteristics with levels of immune markers. Table S3. Overview of quality control of all assessed inflammatory markers (analytes). (DOC 224Â kb)
95. Additional file 1: Table S1. of Inflammatory profile in LRRK2-associated prodromal and clinical PD
- Author
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Brockmann, Kathrin, Apel, Anja, Schulte, Claudia, Schneiderhan-Marra, Nicole, Claustre Pont-Sunyer, Vilas, Dolores, Ruiz-Martinez, Javier, Langkamp, Markus, Jean-Christophe Corvol, Cormier, Florence, Knorpp, Thomas, Joos, Thomas, Gasser, Thomas, SchĂźle, Birgitt, Aasly, Jan, Foroud, Tatiana, Marti-Masso, Jose, Brice, Alexis, Tolosa, Eduardo, Marras, Connie, Berg, Daniela, and Maetzler, Walter
- Subjects
3. Good health - Abstract
Overview of frequency of each LRRK2 mutation in the respective cohorts. Table S2. Overview of results from multivariate linear regression analyses stratified by cohort to illustrate independent associations between gender, age, disease duration, regular intake of anti-inflammatory medication, and clinical characteristics with levels of immune markers. Table S3. Overview of quality control of all assessed inflammatory markers (analytes). (DOC 224Â kb)
96. Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson’s disease
- Author
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Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicas, The Catalonian Neuroimaging Parkinson’s disease Consortium, Castellanos, Gabriel, Martínez, Martín, Ariz, Mikel, Alvarez, Ignacio, Aguilar, Miquel, Hernández-Vara, Jorge, Caballol, Núria, Garrido, Alicia, Bayés, Àngels, Vilas, Dolores, Marti, Maria Jose, Pastor, Pau, Ortiz de Solórzano, Carlos, Pastor, Maria A., Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicas, The Catalonian Neuroimaging Parkinson’s disease Consortium, Castellanos, Gabriel, Martínez, Martín, Ariz, Mikel, Alvarez, Ignacio, Aguilar, Miquel, Hernández-Vara, Jorge, Caballol, Núria, Garrido, Alicia, Bayés, Àngels, Vilas, Dolores, Marti, Maria Jose, Pastor, Pau, Ortiz de Solórzano, Carlos, and Pastor, Maria A.
97. Progression of brain cholinergic dysfunction in patients with isolated rapid eye movement sleep behavior disorder.
- Author
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Staer K, Iranzo A, Terkelsen MH, Stokholm MG, Danielsen EH, Østergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Santamaria J, Møller A, Gaig C, Brooks DJ, Borghammer P, Tolosa E, and Pavese N
- Subjects
- Humans, Acetylcholinesterase, Donepezil, Brain diagnostic imaging, REM Sleep Behavior Disorder psychology, Parkinson Disease
- Abstract
Background: Reduced cortical acetylcholinesterase activity, as measured by
11 C-donepezil positron emission tomography (PET), has been reported in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD). However, its progression and clinical implications have not been fully investigated. Here, we explored the relationship between longitudinal changes in brain acetylcholinesterase activity and cognitive function in iRBD., Methods: Twelve iRBD patients underwent11 C-donepezil PET at baseline and after 3 years. PET images were interrogated with statistical parametric mapping (SPM) and a regions of interest (ROI) approach. Clinical progression was assessed with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III). Cognitive function was rated using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA)., Results: From baseline to follow-up, the mean11 C-donepezil distribution volume ratio (DVR) decreased in the cortex (p = 0.006), thalamus (p = 0.013), and caudate (p = 0.013) ROI. Despite no significant changes in the group mean MMSE or MoCA scores being observed, individually, seven patients showed a decline in their scores on these cognitive tests. Subgroup analysis showed that only the subgroup of patients with a decline in cognitive scores had a significant reduction in mean cortical11 C-donepezil DVR., Conclusions: Our results show that severity of brain cholinergic dysfunction in iRBD patients increases significantly over 3 years, and those changes are more severe in those with a decline in cognitive test scores., (© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)- Published
- 2024
- Full Text
- View/download PDF
98. Parsonage-Turner Syndrome After COVID-19 Vaccination in a Child.
- Author
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Cassart EM, Vilas DR, Abe R, and Cavanilles-Walker JM
- Subjects
- Male, Humans, Child, Adolescent, COVID-19 Vaccines adverse effects, BNT162 Vaccine, Vaccination adverse effects, Brachial Plexus Neuritis etiology, COVID-19 prevention & control
- Abstract
Parsonage-Turner syndrome (PTS) is a peripheral neuropathy involving the brachial plexus very rare in childhood. To date, no cases of PTS after COVID-19 vaccination have been reported in children. We report a case of a 15-year-old boy affected by PTS after the second dose of the BNT162b2 (Comirnaty, Pfizer-BioNTech) COVID-19 vaccine., (Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Orthopaedic Surgeons.)
- Published
- 2023
- Full Text
- View/download PDF
99. Atypical presentation of adult-age onset subacute sclerosing panencephalitis.
- Author
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Vilas D, Becerra JL, Lozano M, Soriano A, Matas L, Martro E, and Dávalos A
- Subjects
- Adult, Brain pathology, Brain physiopathology, Electroencephalography, Humans, Magnetic Resonance Imaging, Male, Measles complications, Measles virus genetics, Measles virus immunology, Subacute Sclerosing Panencephalitis etiology, Young Adult, Subacute Sclerosing Panencephalitis pathology, Subacute Sclerosing Panencephalitis physiopathology
- Published
- 2012
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