Search

Your search keyword '"Vico L"' showing total 683 results
Start Over Author "Vico L"
683 results on '"Vico L"'

54. 3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis

Author

Laib, A., Barou, O., Vico, L., Lafage-Proust, M., Alexandre, C., Rügsegger, P., Laib, A., Barou, O., Vico, L., Lafage-Proust, M., Alexandre, C., and Rügsegger, P.

Abstract

Bone mass and microarchitecture are the main determinants of bone strength. Three-dimensional micro-computed tomogrpahy has the potential to examine complete bones of small laboratory animals with very high resolution in a non-invasive way. In the presented work, the proximal part of the tibiae of hindlimb unloaded and control rats were measured with 3D MicroCT, and the secondary spongiosa of the scanned region was evaluated using direct evaluation techniques that do not require model assumptions. For determination of the complete bone status, the cortex of the tibiae was evaluated and characterised by its thickness. It is shown that with the proposed anatomically conforming volume of interest (VOI), up to an eight-fold volume increase can be evaluated compared to cubic or spherical VOIs. A pronounced trabecular bone loss of −50% is seen after 23 days of tail suspension. With the new evaluation techniques, it is shown that most of this bone loss is caused by the thinning of trabeculae, and to a lesser extent by a decrease in their number. What changes most radically is the structure type: the remaining bone is more rod-like than the control group's bone. Cortical bone decreases less than trabecular bone, with only −18% after 23 days

Published
2018

55. Cortical and Trabecular Bone Microstructure Did Not Recover at Weight-Bearing Skeletal Sites and Progressively Deteriorated at Non-Weight-Bearing Sites During the Year Following International Space Station Missions

Author

Vico, L., van Rietbergen, B., Vilayphiou, N., Linossier, M.T., Locrelle, H., Normand, M., Zouch, M., Gerbaix, M., Bonnet, N., Novikov, V., Thomas, T., Vassilieva, G., and Orthopaedic Biomechanics

Subjects
Adult, ddc:616, BONE HR-pQCT, Radius/anatomy & histology, Walking, Middle Aged, Space Flight, BONE RECOVERY, MICROGRAVITY, Biomechanical Phenomena, Tibia/anatomy & histology, Cortical Bone/anatomy & histology, Weight-Bearing, SDG 3 - Good Health and Well-being, Cancellous Bone/anatomy & histology, PERIOSTIN, Humans, Bone Density/physiology, Tomography, X-Ray Computed, SPACEFLIGHT, Biomarkers/blood
Abstract

Risk for premature osteoporosis is a major health concern in astronauts and cosmonauts; the reversibility of the bone lost at the weight-bearing bone sites is not established, although it is suspected to take longer than the mission length. The bone three-dimensional structure and strength that could be uniquely affected by weightlessness is currently unknown. Our objective is to evaluate bone mass, microarchitecture, and strength of weight-bearing and non-weight-bearing bone in 13 cosmonauts before and for 12 months after a 4-month to 6-month sojourn in the International Space Station (ISS). Standard and advanced evaluations of trabecular and cortical parameters were performed using high-resolution peripheral quantitative computed tomography. In particular, cortical analyses involved determination of the largest common volume of each successive individual scan to improve the precision of cortical porosity and density measurements. Bone resorption and formation serum markers, and markers reflecting osteocyte activity or periosteal metabolism (sclerostin, periostin) were evaluated. At the tibia, in addition to decreased bone mineral densities at cortical and trabecular compartments, a 4% decrease in cortical thickness and a 15% increase in cortical porosity were observed at landing. Cortical size and density subsequently recovered and serum periostin changes were associated with cortical recovery during the year after landing. However, tibial cortical porosity or trabecular bone failed to recover, resulting in compromised strength. The radius, preserved at landing, unexpectedly developed postflight fragility, from 3 months post-landing onward, particularly in its cortical structure. Remodeling markers, uncoupled in favor of bone resorption at landing, returned to preflight values within 6 months, then declined farther to lower than preflight values. Our findings highlight the need for specific protective measures not only during, but also after spaceflight, because of continuing uncertainties regarding skeletal recovery long after landing.

Published
2017

56. Oxidative imbalance in low/intermediate-1-risk myelodysplastic syndrome patients: The influence of iron overload

Author

Ivars D, Orero MT, Javier K, Díaz-Vico L, García-Giménez JL, Mena S, Tormos C, Egea M, Pérez PL, Arrizabalaga B, Ruiz MÁ, Yagüe N, Tormo M, Sancho-Tello R, Gomes A, Algueró C, O'Connor JE, Sáez GT, Carbonell F, and Collado R

Subjects
Oxidative stress, Antioxidant defence, Myelodysplastic syndromes, Iron overload, 8-oxo-dG, Superoxide anion
Abstract

Objective: To assess the generation of reactive oxygen species (ROS) and the involvement of the main antioxidant pathways in low/intermediate-1-risk myelodysplastic syndromes (MDS) with iron overload (IOL). Methods: We examined the levels of superoxide anion (O-2 center dot(-)), hydrogen peroxide (H2O2), antioxidants (glutathione, GSH; superoxide dismutase, SOD; catalase, CAT; and glutathione peroxidase, GPx), mitochondrial membrane potential (Delta Psi m), and by-products of oxidative damage (8-isoprostanes and 8-oxo-7,8-dihydro-2'-deoxyguanosine, 8-oxo-dG) in 42 MDS patients (28 without IOL at diagnosis, and 14 who developed IOL) and 20 healthy subjects. Results: Patients with IOL showed higher O-2 center dot(-) levels (39.4 MFI) than normal controls (22.7 MFI, p = 0.0356) and patients at diagnosis (19.4 MFI, p = 0.0049). Antioxidant systems, except SOD activity, exhibited significant changes in IOL patients with respect to controls (CAT: 7.1 vs 2.7 nmol/ml/min, p = 0.0023; GPx: 50.9 vs 76.4 nmol/ml/min, p = 0.0291; GSH: 50.2 vs 24.1 MFI, p = 0.0060). Furthermore, mitochondrial dysfunction was only detected in IOL cases compared to controls (Delta Psi m: 3.6 vs 6.4 MFI, p = 0.0225). Finally, increased levels of 8-oxo-dG were detected in both groups of patients. Conclusion: Oxidative stress is an important but non-static phenomenon in MDS disease, whose status is influenced by, among other factors, the presence of injurious iron.

Published
2017

58. The role of Dietitian in cardiac rehabilitation and prevention

Author

Brazzo S, Agostini S, Scapolo M, Masini Ml, da Vico L, and Biffi B

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Heart Diseases, medicine.medical_treatment, Psychological intervention, MEDLINE, role of Dietitian, lcsh:Medicine, Scientific literature, Disease, Professional Role, Nursing, medicine, Humans, Medical nutrition therapy, multidisciplinary strategies, Rehabilitation, business.industry, lcsh:R, cardiac rehabilitation, Italy, Family medicine, Position paper, Nutrition Therapy, Cardiology and Cardiovascular Medicine, business, Psychosocial
Abstract

Rehabilitation and secondary prevention programs are recognized as an essential part of the overall care of patients with cardiovascular disease. They consist of multidisciplinary strategies aiming at the reduction of modifiable risk factors for cardiovascular disease. Cardiac rehabilitation includes non-pharmacological interventions as: Patients’ evaluation. Nutritional counseling. Risk factors management (serum lipids, blood pressure, weight, diabetes, smoking). Psychosocial interventions. Physical activity and cardiovascular physical training counseling. Their effectiveness in the reduction of mortality through the decrease of risk factors has been proven in the last twenty years. Guidelines on appropriate and well-framed interventions have been released and nutritional interventions have a ringside seat in all programs. During 2007, the Italian Association of Dietitians, ANDID, created a working group of expert dietitians, with the goals of making a review of available scientific literature and of elaborating a Professional Position Papers on the role of Dietitian in cardiac rehabilitation and prevention. This Position Paper retrieves and remarks the available evidence that are important for the dietitians, according to their professional role and their contribution in the management of the topic.

Published
2016

59. Bone density in cosmonauts

Author

Schneider, Peter, Reiners, Christoph, Vico, L, Lafage-Proust, M H, Collet, P, Rehailia, M, and Alexandre, C

Subjects
Bones -- Density, Astronauts -- Physiological aspects, Reduced gravity environments -- Physiological aspects
Published
2000

60. Use of TALEN for a double gene extinction on two closely linked loci

Author

Teixeira, M., Bouleftour, W., Thomas, M., Concordet, J. P., Aubert, Denise, Machuca, Irma, Vico, L., Lafage-Proust, M. H., Malaval, L., Plateau de Biologie Expérimentale de la Souris, Partenaires INRAE, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle de Lyon (IGFL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), ProdInra, Migration, École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

61. The Artificial Gravity Platform (AGP); a Very Large Radius Centrifuge as Human Hypergravity Habitat

Author

Jack JWA van Loon, Albiol, J., Baeyens, J. P., Barakova, E., Belavy, D., Berte, J., Blanc, S., Bok, K., Bos, J., Boyle, R., Braak, L., Bravenboer, N., Carotenuto, L., Chouker, A., Clement, G., Cras, P., Cross, E., Custaud, M. A., DE ANGELIS, Marco, de Boever, P., de Haas, O., Delavaux, T., Delfos, R., Denise, P., Eekhoff, M., Eiken, O., Felsenberg, D., Fong, K., Fuller, C., Goswami, N., Grillner, S., Groen, E., Harlaar, J., Heer, M., Heglund, N., Hinghofer Szalkay, H., Hughes Fulford, M., Iwase, S., Karemaker, Jm, Langdahl, B., Linnarsson, D., Lobascio, C., Lüthen, C., Mayrhofer, M., Mekjavic, I., Monici, M., Moss, M., Mulder, E., Narici, M., Norsk, P., O’Gorman, D., Paloski, W., Poelma, C., Prisk, K., Rauterberg, M., Rutten, M., Schultz, L., Singer, P., Sommeria, J., Stegeman, D., Stephan, A., Stienen, G., Strollo, F., Stutte, G., Suedfeld, P., Tesch, P., Ullrich, O., van den Berg, R., van de Heyning, P., GJ van Heijst, Vico, L., Woodward, E., Young, L., and Wuyts, F. L.

Published
2014

67. The Artificial Gravity Platform, AGP a very Large Radius Human Centrifuge

Author

van Loon, J. J. W. A., Baeyens, Jp, Berte, J., Blanc, S., Braak, L., Bok, K., Bos, J., Boyle, R., Bravenoer, N., Eekhoff, M., Chouker, A., Clement, G., Cras, P., Cross, Cusaud, DE ANGELIS, Marco, de Dreu, C., Delavaux, T., Delfos, R., Poelma, C., Denise, P., Felsenberg, D., Fong, K., Fuller, C., Grillner, Groen, E., Harlaar, Heer, M., Neuss, Heglund, N., Hinghofer Szalkay, H., Goswami, N., Graz, Hughes Fulfordn, M., Iwase, S., Karemaker, J. M., Langdahl, B., Linnarsson, D., Lüthen, C., Manzey, Monici, M., Mulder, E., Narici, M., Norsk, P., Paloski, W., Prisk, K., Rutten, M., Singer, Stegeman, D., Stephan, A., Stienen, G., Suedfeld, P., Tesch, P., Ullrich, O., Van den Berg, R., Van de Heyning, P., Vautmans, L., Veyt, J., Vico, L., Woodward, Young, L., and Wuyts, F.

Published
2013

68. A Large Human Centrifuge for Exploration and Exploitation Research

Author

Loon, J. J. W. A., Baeyens, J. P., Berte, J., Blanc, S., Braak, L., Bok, K., Jelte Bos, Boyle, R., Bravenboer, N., Eekhoff, E. M. W., Chouker, A., Clement, G., Cras, P., Cross, E., Custaud, M. A., Angelis, M., Delavaux, T., Delfos, R., Poelma, C., Denise, P., Felsenberg, D., Fong, K., Fuller, C., Grillner, S., Groen, E., Harlaar, J., Heer, M., Heglund, N., Hinghofer-Szalkay, H., Goswami, N., Hughes-Fulford, M., Iwase, S., Karemaker, J. M., Langdahl, B. L., Linnarsson, D., Lüthen, C., Monici, M., Mulder, E., Narici, M. V., Norsk, P., Paloski, W., Prisk, K., Rutten, M., Singer, P., Stegeman, D. F., Stephan, A., Stienen, G. J. M., Suedfeld, P., Tesch, P., Ullrich, O., Den Berg, R., Heyning, P., Delahaye, A., Veyt, J., Vico, L., Woodward, E., Young, L., Wuyts, F. L., Oral and Maxillofacial Surgery / Oral Pathology, Clinical chemistry, Internal medicine, Rehabilitation medicine, Physiology, MOVE Research Institute, Kinesiology, Movement Behavior, and Research Institute MOVE

Published
2012

69. A Large Human Centrifuge for Exploration and Exploratory Research

Author

van Loon, J. J. W. A., Baeyens, Jp, Berte, J., Blanc, S., Braak, L., Bok, K., Bos, J., Boyle, R., Bravenoer, N., Eekhoff, M., Chouker, A., Clement, G., Cras, P., Cross, Cusaud, DE ANGELIS, Marco, de Dreu, C., Delavaux, T., Delfos, R., Poelma, C., Denise, P., Felsenberg, D., Fong, K., Fuller, C., Grillner, Groen, E., Harlaar, Heer, M., Neuss, Heglund, N., Hinghofer Szalkay, H., Goswami, N., Graz, Hughes Fulfordn, M., Iwase, S., Karemaker, J. M., Langdahl, B., Linnarsson, D., Lüthen, C., Manzey, Monici, M., Mulder, E., Narici, M., Norsk, P., Paloski, W., Prisk, K., Rutten, M., Singer, Stegeman, D., Stephan, A., Stienen, G., Suedfeld, P., Tesch, P., Ullrich, O., Van den Berg, R., Van de Heyning, P., Vautmans, L., Veyt, J., Vico, L., Woodward, Young, L., and Wuyts, F.

Published
2012

70. A Large Human Centrifuge for Exploration end Explotation Research

Author

van Loon, J. J. W. A., Baeyens, Jp, Berte, J., Blanc, S., Braak, L., Bok, K., Bos, J., Boyle, R., Bravenoer, N., Eekhoff, M., Chouker, A., Clement, G., Cras, P., Cross, Cusaud, DE ANGELIS, Marco, de Dreu, C., Delavaux, T., Delfos, R., Poelma, C., Denise, P., Felsenberg, D., Fong, K., Fuller, C., Grillner, Groen, E., Harlaar, Heer, M., Neuss, Heglund, N., Hinghofer Szalkay, H., Goswami, N., Graz, Hughes Fulfordn, M., Iwase, S., Karemaker, J. M., Langdahl, B., Linnarsson, D., Lüthen, C., Manzey, Monici, M., Mulder, E., Narici, M., Norsk, P., Paloski, W., Prisk, K., Rutten, M., Singer, Stegeman, D., Stephan, A., Stienen, G., Suedfeld, P., Tesch, P., Ullrich, O., Van den Berg, R., Van de Heyning, P., Vautmans, L., Veyt, J., Vico, L., Woodward, Young, L., and Wuyts, F.

Subjects
Hypergravity • Artificial gravity • Microgravity • Weightlessness • Centrifuge • Gravity continuum • Mars • Moon • Human exploration • Human Hypergravity Habitat
Published
2011

72. Constitutional thinness: unusual human phenotype of low bone quality

Author

Lang, François, Galusca, Bogdan, Zouch, M., Germain, Natacha, Bossu, Cécile, Frere, D., Lafague-Proust, M.-H., Thomas, T., Vico, L., Estour, Bruno, Dynamique des capacités humaines et des conduites de santé (EPSYLON), and Université de Montpellier (UM)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université Montpellier 1 (UM1)

Subjects
[SCCO.PSYC]Cognitive science/Psychology
Abstract

International audience; CONTEXT: Low fat mass and hormonal or nutritional deficiencies are often incriminated in bone loss related to thinness. Constitutional thinness has been described in young women with low body mass index (BMI) but close-to-normal body composition, physiological menstruation, no hormonal abnormalities, and no anorexia nervosa (AN) psychological profile.OBJECTIVE: Our objective was to determine whether constitutional thinness is associated with impaired bone quality.DESIGN, SETTING, AND PARTICIPANTS: This was an observational, cross-sectional study on 25 constitutionally thin and 44 AN young women with similar low BMI (

Published
2008

75. Il sito: L'architettura

Author

Vico L., Vassallo, Di Ioia, and Moro

Subjects
Architettura, Roma, Villa_di_Livia, Realtà virtuale
Published
2007

76. L'interpretazione

Author

Vico L. and Vassallo

Subjects
Archeologia, Roma, Realtà_Virtuale, Villa_di_Livia
Published
2007

88. Predicting and rationalizing the effect of surface charge distribution and orientation on nano-wire based FET bio-sensors

Author

De Vico, L., Iversen, L., Sørensen, Martin Hedegård, Brandbyge, Mads, Nygard, J., Martinez, K.L., Jensen, J.H., De Vico, L., Iversen, L., Sørensen, Martin Hedegård, Brandbyge, Mads, Nygard, J., Martinez, K.L., and Jensen, J.H.

Abstract

A single charge screening model of surface charge sensors in liquids (De Vico et al., Nanoscale, 2011, 3, 706-717) is extended to multiple charges to model the effect of the charge distributions of analyte proteins on FET sensor response. With this model we show that counter-intuitive signal changes (e.g. a positive signal change due to a net positive protein binding to a p-type conductor) can occur for certain combinations of charge distributions and Debye lengths. The new method is applied to interpret published experimental data on Streptavidin (Ishikawa et al., ACS Nano, 2009, 3, 3969-3976) and Nucleocapsid protein (Ishikawa et al., ACS Nano, 2009, 3, 1219-1224).

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results