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51. Genome‐wide association study of methotrexate‐induced liver injury in rheumatoid arthritis patients

Author

Eektimmerman, Frank, primary, Swen, Jesse J., additional, den Broeder, Alfons A., additional, Hazes, Johanna M.W., additional, Kurreeman, Fina S., additional, Verstappen, Suzanne M.M., additional, Nair, Nisha, additional, Pawlik, Andrzej, additional, Nurmohamed, Mike T., additional, Dolžan, Vita, additional, Böhringer, Stefan, additional, Allaart, Cornelia F., additional, and Guchelaar, Henk‐Jan, additional

Published
2023
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52. Non-pharmacological interventions to promote work participation in people with rheumatic and musculoskeletal diseases: a systematic review and meta-analysis from the EULAR taskforce on healthy and sustainable work participation

Author

Butink, Maarten H P, primary, Webers, Casper, additional, Verstappen, Suzanne M M, additional, Falzon, Louise, additional, Betteridge, Neil, additional, Wiek, Dieter, additional, Woolf, Anthony D, additional, Stamm, Tanja A, additional, Burmester, Gerd R, additional, Bijlsma, Johannes W J, additional, Christensen, Robin, additional, and Boonen, Annelies, additional

Published
2023
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55. Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis

Author

Gwinnutt, James M., primary, Norton, Sam, additional, Hyrich, Kimme L., additional, Lunt, Mark, additional, Combe, Bernard, additional, Rincheval, Nathalie, additional, Ruyssen‐Witrand, Adeline, additional, Fautrel, Bruno, additional, McWilliams, Daniel F., additional, Walsh, David A., additional, Nikiphorou, Elena, additional, Kiely, Patrick D. W., additional, Young, Adam, additional, Chipping, Jacqueline R., additional, MacGregor, Alex, additional, and Verstappen, Suzanne M. M., additional

Published
2022
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56. The association between lower socioeconomic position and functional limitations is partially mediated by obesity in older adults with symptomatic knee osteoarthritis: Findings from the English Longitudinal Study of Ageing

Author

Witkam, Rozemarijn, primary, Verstappen, Suzanne M. M., additional, Gwinnutt, James M., additional, Cook, Michael J., additional, O'Neill, Terence W., additional, Cooper, Rachel, additional, and Humphreys, Jennifer, additional

Published
2022
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60. Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling

Author

Soomro, Mehreen, Stadler, Michael, Dand, Nick, Bluett, James, Jadon, Deepak, Jalali-Najafabadi, Farideh, Duckworth, Michael, Ho, Pauline, Marzo-Ortega, Helena, Helliwell, Philip S, Ryan, Anthony W, Kane, David, Korendowych, Eleanor, Simpson, Michael A, Packham, Jonathan, McManus, Ross, Gabay, Cem, Lamacchia, Céline, Nissen, Michael J, Brown, Matthew A, Verstappen, Suzanne MM, Van Staa, Tjeerd, Barker, Jonathan N, Smith, Catherine H, BADBIR Study Group, BSTOP Study Group, FitzGerald, Oliver, McHugh, Neil, Warren, Richard B, Bowes, John, Barton, Anne, Stadler, Michael [0000-0003-3689-4256], Helliwell, Philip S [0000-0002-4155-9105], McManus, Ross [0000-0002-0529-9617], Lamacchia, Céline [0000-0002-0291-8865], and Apollo - University of Cambridge Repository

Subjects
Biological Products, Risk Factors, Case-Control Studies, Arthritis, Psoriatic, Humans, Psoriasis, Genetic Predisposition to Disease
Abstract

Funder: Cambridge Arthritis Research Endeavour (CARE), Funder: Leeds NIHR Biomedical Research Centre, Funder: Manchester NIHR Biomedical Research Centre, Funder: National Institute for Health Research; Id: http://dx.doi.org/10.13039/501100000272, Funder: NIHR Manchester BRC; Id: http://dx.doi.org/10.13039/100014653, OBJECTIVES: Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk factors and pathways that differentiate PsA from cutaneous-only psoriasis (PsC) and to evaluate the performance of PsA risk prediction models. METHODS: Genome-wide meta-analyses were conducted separately for 5,065 patients with PsA and 21,286 healthy controls and separately for 4,340 patients with PsA and 6,431 patients with PsC. The heritability of PsA was calculated as a single-nucleotide polymorphism (SNP)-based heritability estimate (h2 SNP ) and biologic pathways that differentiate PsA from PsC were identified using Priority Index software. The generalizability of previously published PsA risk prediction pipelines was explored, and a risk prediction model was developed with external validation. RESULTS: We identified a novel genome-wide significant susceptibility locus for the development of PsA on chromosome 22q11 (rs5754467; P = 1.61 × 10-9 ), and key pathways that differentiate PsA from PsC, including NF-κB signaling (adjusted P = 1.4 × 10-45 ) and Wnt signaling (adjusted P = 9.5 × 10-58 ). The heritability of PsA in this cohort was found to be moderate (h2 SNP = 0.63), which was similar to the heritability of PsC (h2 SNP = 0.61). We observed modest performance of published classification pipelines (maximum area under the curve 0.61), with similar performance of a risk model derived using the current data. CONCLUSION: Key biologic pathways associated with the development of PsA were identified, but the investigation of risk classification revealed modest utility in the available data sets, possibly because many of the PsC patients included in the present study were receiving treatments that are also effective in PsA. Future predictive models of PsA should be tested in PsC patients recruited from primary care.

Published
2022

61. The influence of social support, financial status and lifestyle on the disparity between inflammation and disability in rheumatoid arthritis

Author

Gwinnutt, James M, Norton, Sam, Hyrich, Kimme L, Lunt, Mark, Combe, Bernard, Rincheval, Nathalie, Ruyssen?Witrand, Adeline, Fautrel, Bruno, McWilliams, Daniel F, Walsh, David A, Nikiphorou, Elena, Kiely, Patrick DW, Young, Adam, Chipping, Jacqueline R, MacGregor, Alex, and Verstappen, Suzanne MM

Subjects
Rheumatology
Abstract

ObjectivesTo investigate how social support, financial status and lifestyle influence the development of excess disability in rheumatoid arthritis (RA).MethodsData came from the Étude et Suivi des Polyarthrites Indifférenciées Récentes (ESPOIR) cohort study of people with RA. A previous analysis identified groups with similar inflammation trajectories but markedly different disability over 10 years; those in the higher disability trajectory groups were defined as having “excess disability”. Participants self-reported data on contextual factors (social support, financial situation, lifestyle) and completed patient reported outcome measures (PROMs; pain, fatigue, anxiety, depression) at baseline. The direct effect of the contextual factors on excess disability and the effect mediated by PROMs was assessed using structural equation models. Findings were validated within two independent datasets (Norfolk Arthritis Register [NOAR], Early Rheumatoid Arthritis Network [ERAN]).ResultsOf 538 included ESPOIR participants (mean age [standard deviation (SD)]: 48.3 [12.2] years, 79.2% women), 200 (37.2%) were in the excess disability group. Less social support (β 0.17 [95% CI 0.08, 0.26]), worse financial situation (β 0.24 [95% CI 0.14, 0.34]), less exercise (β 0.17 [95% CI 0.09, 0.25]) and less education (β 0.15 [95% CI 0.06, 0.23]) were associated with excess disability group membership; smoking, alcohol consumption and body mass index were not. Fatigue and depression mediated a small proportion of these effects. Similar results were seen in NOAR and ERAN.ConclusionsGreater emphasis is needed on the economic and social context of people with RA at presentation; these factors might influence disability over the following decade.

Published
2022

64. 2021 EULAR points to consider to support people with rheumatic and musculoskeletal diseases to participate in healthy and sustainable paid work

Author

Boonen, Annelies, primary, Webers, Casper, additional, Butink, Maarten, additional, Barten, Birgit, additional, Betteridge, Neil, additional, Black, Dame Carol, additional, Bremander, Ann, additional, Boteva, Boryana, additional, Brzezińska, Olga, additional, Chauhan, Lina, additional, Copsey, Sarah, additional, Guimarães, Vera, additional, Gignac, Monique, additional, Glaysher, Jennifer, additional, Green, Frans, additional, Hoving, Jan L, additional, Marques, Mary Lucy, additional, Smucrova, Hana, additional, Stamm, Tanja A, additional, Wiek, Dieter, additional, Wilkie, Ross, additional, Woolf, Anthony D, additional, Burmester, Gerd R, additional, Bijlsma, Johannes W, additional, and Verstappen, Suzanne M M, additional

Published
2022
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65. Linguistic validation, validity, and reliability of the British English version of the Workplace Activity Limitations Scale in employed people with rheumatoid arthritis, ankylosing spondyloarthritis, osteoarthritis and fibromyalgia .

Author

Hammond, Alison, primary, Tennant, Alan, additional, Ching, Angela, additional, Parker, Jennifer, additional, Prior, Yeliz, additional, Gignac, Monique, additional, Verstappen, Suzanne, additional, and O'Brien, Rachel, additional

Published
2022
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67. Implementation of recommendations in rheumatic and musculoskeletal diseases: considerations for development and uptake

Author

Loza, Estibaliz, primary, Carmona, Loreto, additional, Woolf, Anthony, additional, Fautrel, Bruno, additional, Courvoisier, Delphine S, additional, Verstappen, Suzanne, additional, Aarrestad Provan, Sella, additional, Boonen, Annelies, additional, Vliet Vlieland, Thea, additional, Marchiori, Francesca, additional, Jasinski, Tiina, additional, Van der Elst, Kristien, additional, Ndosi, Mwidimi, additional, Dziedzic, Krysia, additional, and Carrasco, Jose Miguel, additional

Published
2022
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70. RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients

Author

Isaacs, John D., Brockbank, Sarah, Pedersen, Ayako Wakatsuki, Hilkens, Catharien, Anderson, Amy, Stocks, Philip, Lendrem, Dennis, Tarn, Jessica, Smith, Graham R., Allen, Ben, Casement, John, Diboll, Julie, Harry, Rachel, Cooles, Faye A. H., Cope, Andrew P., Simpson, Gemma, Toward, Ruth, Noble, Hayley, Parke, Angela, Wu, Wing, Clarke, Fiona, Scott, David, Scott, Ian C., Galloway, James, Lempp, Heidi, Ibrahim, Fowzia, Schwank, Samana, Molyneux, Gemma, Lazarov, Tomi, Geissmann, Frederic, Goodyear, Carl S., McInnes, Iain B., Donnelly, Iona, Gilmour, Ashley, Virlan, Aysin Tulunay, Porter, Duncan, Ponchel, Frederique, Emery, Paul, El-Jawhari, Jehan, Parmar, Rekha, McDermott, Michael F., Fisher, Benjamin A., Young, Steve P., Jones, Philip, Raza, Karim, Filer, Andrew, Pitzalis, Costantino, Barnes, Michael R., Watson, David S., Henkin, Rafael, Thorborn, Georgina, Fossati-Jimack, Liliane, Kelly, Stephen, Humby, Frances, Bombardieri, Michele, Rana, Sharmila, Jia, Zhilong, Goldmann, Katriona, Lewis, Myles, Ng, Sandra, Barbosa-Silva, Adriano, Tzanis, Evan, Gallagher-Syed, Amaya, John, Christopher R., Ehrenstein, Michael R., Altobelli, Gioia, Martins, Sandra, Nguyen, Dao, Ali, Humayara, Ciurtin, Coziana, Buch, Maya, Symmons, Deborah, Worthington, Jane, Bruce, Ian N., Sergeant, Jamie C., Verstappen, Suzanne M. M., Stirling, Fiona, Hughes-Morley, Adwoa, Tom, Brian, Farewell, Vernon, Zhong, Yujie, Taylor, Peter C., Buckley, Christopher D., Keidel, Sarah, Cuff, Carolyn, Levesque, Marc, Long, Andrew, Liu, Zheng, Lipsky, Samantha, Harvey, Bohdan, Macoritto, Michael, Hong, Feng, Kaymakcalan, Sukru, Tsuji, Wayne, Sabin, Tony, Ward, Neil, Talbot, Susan, Padhji, Desmond, Sleeman, Matthew, Finch, Donna, Herath, Athula, Lindholm, Catharina, Jenkins, Martin, Ho, Meilien, Hollis, Sally, Marshall, Chris, Parker, Gerry, Page, Matt, Edwards, Hannah, Cuza, Alexandru, Gozzard, Neil, Pandis, Ioannis, Rowe, Anthony, Capdevila, Francisco Bonachela, Loza, Matthew J., Curran, Mark, Verbeeck, Denny, Dan Baker, Mela, Christopher M., Vranic, Ivana, Mela, Catherine T., Wright, Stephen, Rowell, Lucy, Vernon, Emma, Joseph, Nina, Payne, Neil, Rao, Ravi, Binks, Michael, Belson, Alexandra, Ludbrook, Valerie, Hicks, Kirsty, Tipney, Hannah, Ellis, Joanne, Hasan, Samiul, Didierlaurent, Arnaud, Burny, Wivine, Haynes, Andrea, Larminie, Chris, Harris, Ray, Dastros-Pitei, Daniela, Carini, Claudio, Kola, Blerina, Jelinsky, Scott, Hodge, Martin, Maciejewski, Mateusz, Ziemek, Daniel, Schulz-Knappe, Peter, Zucht, Hans-Dieter, Budde, Petra, Coles, Mark, Butler, James A., Read, Simon, and Consortium, The RA-MAP

Subjects
Arthritis, Rheumatoid, Proteomics, Statistics and Probability, Vaccines, Humans, Library and Information Sciences, Statistics, Probability and Uncertainty, Monocytes, Autoantibodies, Biological Specimen Banks, Computer Science Applications, Education, Information Systems
Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA.

Published
2022
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74. Is the relationship between deprivation and outcomes in rheumatoid arthritis mediated by body mass index? A longitudinal cohort study.

Author

Witkam, Rozemarijn, Gwinnutt, James M, Humphreys, Jennifer, Verstappen, Suzanne M M, and Co-Investigators, RAMS

Subjects
OBESITY complications, RHEUMATOID arthritis risk factors, RESEARCH, SCIENTIFIC observation, CONFIDENCE intervals, SELF-evaluation, HEALTH outcome assessment, RISK assessment, FACTOR analysis, DESCRIPTIVE statistics, WEIGHT loss, RESEARCH funding, BODY mass index, LONGITUDINAL method
Abstract

Objectives To understand the relationships between deprivation and obesity with self-reported disability and disease activity in people with RA, and to determine whether BMI mediates the relationship between area-level deprivation and these outcomes. Methods Data came from the Rheumatoid Arthritis Medication Study (RAMS), a 1-year multicentre prospective observational cohort of people with RA recruited from rheumatology centres across England commencing MTX for the first time. A total of 1529 and 1626 people were included who had a baseline and at least one follow-up measurement at 6 or 12 months of HAQ—Disability Index (HAQ-DI) and DAS in 28 joints (DAS28), respectively. Linear mixed models estimated the associations of deprivation and obesity with repeated measures HAQ-DI and DAS28. Causal mediation analyses estimated the mediating effect of BMI on the relationship between deprivation and RA outcomes. Results Higher deprivation and obesity were associated with higher disability [adjusted regression coefficients highest vs lowest deprivation fifths 0.32 (95% CI 0.19, 0.45); obesity vs no obesity 0.13 (95% CI 0.06, 0.20)] and higher disease activity [adjusted regression coefficients highest vs lowest deprivation fifths 0.34 (95% CI 0.11, 0.58); obesity vs no obesity 0.17 (95% CI 0.04, 0.31)]. BMI mediated part of the association between higher deprivation and self-reported disability (14.24%) and DAS (17.26%). Conclusions People with RA living in deprived areas have a higher burden of disease, which is partly mediated through obesity. Weight-loss strategies in RA could be better targeted towards those living in deprived areas. [ABSTRACT FROM AUTHOR]

Published
2023
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77. Effects of diet on the outcomes of rheumatic and musculoskeletal diseases (RMDs): systematic review and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs

Author

Gwinnutt, James M, primary, Wieczorek, Maud, additional, Rodríguez-Carrio, Javier, additional, Balanescu, Andra, additional, Bischoff-Ferrari, Heike A, additional, Boonen, Annelies, additional, Cavalli, Giulio, additional, de Souza, Savia, additional, de Thurah, Annette, additional, Dorner, Thomas E, additional, Moe, Rikke Helene, additional, Putrik, Polina, additional, Silva-Fernández, Lucía, additional, Stamm, Tanja, additional, Walker-Bone, Karen, additional, Welling, Joep, additional, Zlatković-Švenda, Mirjana, additional, Guillemin, Francis, additional, and Verstappen, Suzanne M M, additional

Published
2022
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78. The association between lower socioeconomic position and functional limitations is partially mediated by obesity in older adults with symptomatic knee osteoarthritis: findings from the English Longitudinal Study of Ageing

Author

Witkam, Rozemarijn, Verstappen, Suzanne MM, Gwinnutt, James M, Cook, Michael J, O'Neill, Terence W, Cooper, Rachel, Humphreys, Jennifer, Witkam, Rozemarijn, Verstappen, Suzanne MM, Gwinnutt, James M, Cook, Michael J, O'Neill, Terence W, Cooper, Rachel, and Humphreys, Jennifer

Abstract

Objective: To assess the longitudinal associations of socioeconomic position (SEP) with functional limitations and knee joint replacement surgery (JRS) in people with symptomatic knee osteoarthritis (OA), and whether body mass index (BMI) mediated these relationships. Methods: Data came from the English Longitudinal Study of Ageing, a national longitudinal panel study of adults aged ≥50 years. A total of 1,499 participants (62.3% female; mean age 66.5 (standard deviation (SD) 9.4) years; 47.4% obese) self-reporting an OA diagnosis and knee pain, with at least one BMI measurement were included. Mixed effect models estimated longitudinal associations of each SEP variable (education, occupation, income, wealth and deprivation index) and obesity (BMI ≥30.0 kg/m2) with repeated measures of functional limitations. Cox regression analyses estimated associations between SEP indicators and obesity at baseline and risk of knee JRS at follow-up. Structural equation modelling estimated any mediating effects of BMI on these relationships. Results: Lower SEP and obesity at baseline were associated with increased odds of functional limitations in people with knee OA (e.g. difficulty walking 100 yards: no qualification vs degree adjOR 4.33 (95% CI 2.20, 8.55) and obesity vs no obesity adjOR 3.06 (95% CI 2.14, 4.37); similar associations were found for the other SEP indicators). A small proportion of the association between lower SEP and functional limitations could be explained by BMI (6.2–12.5%). Those with lower income, lower wealth and higher deprivation were less likely to have knee JRS (e.g. adjHR most vs least deprived 0.37 (95% CI 0.19, 0.73)); however, no clear association was found for education and occupation. Obesity was associated with increased hazards of having knee JRS (adjHR 1.87 (95% CI 1.32, 2.66)). As the direction of the associations for SEP and obesity with knee JRS were in opposite directions, no mediation analyses were performed. Conclusions: Lower SEP was as

Published
2022

79. Smoking, alcohol consumption and disease-specific outcomes in rheumatic and musculoskeletal diseases (RMDs): systematic reviews informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs

Author

Wieczorek, Maud; https://orcid.org/0000-0002-4528-9923, Gwinnutt, James Martin; https://orcid.org/0000-0002-1435-8797, Ransay-Colle, Maxime, Balanescu, Andra, Bischoff-Ferrari, Heike, Boonen, Annelies; https://orcid.org/0000-0003-0682-9533, Cavalli, Giulio; https://orcid.org/0000-0001-8728-3004, de Souza, Savia, de Thurah, Annette; https://orcid.org/0000-0003-0103-4328, Dorner, Thomas Ernst, Moe, Rikke Helene; https://orcid.org/0000-0001-7601-5346, Putrik, Polina, Rodríguez-Carrio, Javier; https://orcid.org/0000-0002-0011-5102, Silva-Fernández, Lucía, Stamm, Tanja A; https://orcid.org/0000-0003-3073-7284, Walker-Bone, Karen, Welling, Joep, Zlatkovic-Svenda, Mirjana; https://orcid.org/0000-0002-7123-140X, Verstappen, Suzanne MM, Guillemin, Francis; https://orcid.org/0000-0002-9860-7024, Wieczorek, Maud; https://orcid.org/0000-0002-4528-9923, Gwinnutt, James Martin; https://orcid.org/0000-0002-1435-8797, Ransay-Colle, Maxime, Balanescu, Andra, Bischoff-Ferrari, Heike, Boonen, Annelies; https://orcid.org/0000-0003-0682-9533, Cavalli, Giulio; https://orcid.org/0000-0001-8728-3004, de Souza, Savia, de Thurah, Annette; https://orcid.org/0000-0003-0103-4328, Dorner, Thomas Ernst, Moe, Rikke Helene; https://orcid.org/0000-0001-7601-5346, Putrik, Polina, Rodríguez-Carrio, Javier; https://orcid.org/0000-0002-0011-5102, Silva-Fernández, Lucía, Stamm, Tanja A; https://orcid.org/0000-0003-3073-7284, Walker-Bone, Karen, Welling, Joep, Zlatkovic-Svenda, Mirjana; https://orcid.org/0000-0002-7123-140X, Verstappen, Suzanne MM, and Guillemin, Francis; https://orcid.org/0000-0002-9860-7024

Abstract

Background: A EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). The aim of this paper was to review the literature on the relationship between smoking and alcohol consumption with regard to RMD-specific outcomes. Methods: Two systematic reviews were conducted to identify systematic reviews and meta-analyses, published between 2013 and 2018, related to smoking and alcohol consumption in seven RMDs: osteoarthritis (OA), rheumatoid arthritis (RA), systemic lupus erythematosus, axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), systemic sclerosis (SSc) and gout. Two additional systematic reviews were performed to identify original longitudinal studies on smoking and alcohol consumption and disease-specific outcomes. Results: Nine reviews and 65 original studies on smoking as well as two reviews and 14 original studies on alcohol consumption met the inclusion criteria. While most studies were moderate/poor quality, smoking was significantly associated with poorer outcomes: cardiovascular comorbidity; poorer response to RA treatment; higher disease activity and severity in early RA; axSpA radiographic progression. Results were heterogeneous for OA while there was limited evidence for PsA, SSc and gout. Available studies on alcohol mainly focused on RA, reporting a positive association between alcohol intake and radiographic progression. Five studies assessed alcohol consumption in gout, reporting a significant association between the number and type of alcoholic beverages and the occurrence of flares. Conclusion: Current literature supports that smoking has a negative impact on several RMD-specific outcomes and that moderate or high alcohol consumption is associated with increased risk of flares in RA and gout. Keywords: Epidemiology; Patient Reported Outcome Measures; Smoking

Published
2022

80. Effects of diet on the outcomes of rheumatic and musculoskeletal diseases (RMDs): systematic review and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs

Author

Gwinnutt, James M; https://orcid.org/0000-0002-1435-8797, Wieczorek, Maud; https://orcid.org/0000-0002-4528-9923, Rodríguez-Carrio, Javier; https://orcid.org/0000-0002-0011-5102, Balanescu, Andra, Bischoff-Ferrari, Heike A, Boonen, Annelies; https://orcid.org/0000-0003-0682-9533, Cavalli, Giulio; https://orcid.org/0000-0001-8728-3004, de Souza, Savia, de Thurah, Annette; https://orcid.org/0000-0003-0103-4328, Dorner, Thomas E, Moe, Rikke Helene; https://orcid.org/0000-0001-7601-5346, Putrik, Polina, Silva-Fernández, Lucía, Stamm, Tanja; https://orcid.org/0000-0003-3073-7284, Walker-Bone, Karen, Welling, Joep, Zlatković-Švenda, Mirjana; https://orcid.org/0000-0002-7123-140X, Guillemin, Francis; https://orcid.org/0000-0002-9860-7024, Verstappen, Suzanne M M, Gwinnutt, James M; https://orcid.org/0000-0002-1435-8797, Wieczorek, Maud; https://orcid.org/0000-0002-4528-9923, Rodríguez-Carrio, Javier; https://orcid.org/0000-0002-0011-5102, Balanescu, Andra, Bischoff-Ferrari, Heike A, Boonen, Annelies; https://orcid.org/0000-0003-0682-9533, Cavalli, Giulio; https://orcid.org/0000-0001-8728-3004, de Souza, Savia, de Thurah, Annette; https://orcid.org/0000-0003-0103-4328, Dorner, Thomas E, Moe, Rikke Helene; https://orcid.org/0000-0001-7601-5346, Putrik, Polina, Silva-Fernández, Lucía, Stamm, Tanja; https://orcid.org/0000-0003-3073-7284, Walker-Bone, Karen, Welling, Joep, Zlatković-Švenda, Mirjana; https://orcid.org/0000-0002-7123-140X, Guillemin, Francis; https://orcid.org/0000-0002-9860-7024, and Verstappen, Suzanne M M

Abstract

BackgroundA EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). In this paper, the literature on the effect of diet on the progression of RMDs is reviewed.MethodsSystematic reviews and meta-analyses were performed of studies related to diet and disease outcomes in seven RMDs: osteoarthritis (OA), rheumatoid arthritis (RA), systemic lupus erythematosus, axial spondyloarthritis, psoriatic arthritis, systemic sclerosis and gout. In the first phase, existing relevant systematic reviews and meta-analyses, published from 2013 to 2018, were identified. In the second phase, the review was expanded to include published original studies on diet in RMDs, with no restriction on publication date. Systematic reviews or original studies were included if they assessed a dietary exposure in one of the above RMDs, and reported results regarding progression of disease (eg, pain, function, joint damage).ResultsIn total, 24 systematic reviews and 150 original articles were included. Many dietary exposures have been studied (n=83), although the majority of studies addressed people with OA and RA. Most dietary exposures were assessed by relatively few studies. Exposures that have been assessed by multiple, well conducted studies (eg, OA: vitamin D, chondroitin, glucosamine; RA: omega-3) were classified as moderate evidence of small effects on disease progression.ConclusionThe current literature suggests that there is moderate evidence for a small benefit for certain dietary components. High-level evidence of clinically meaningful effect sizes from individual dietary exposures on outcomes in RMDs is missing.

Published
2022

81. Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (RMDs): systematic reviews and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs

Author

Gwinnutt, James M; https://orcid.org/0000-0002-1435-8797, Wieczorek, Maud; https://orcid.org/0000-0002-4528-9923, Cavalli, Giulio; https://orcid.org/0000-0001-8728-3004, Balanescu, Andra, Bischoff-Ferrari, Heike A, Boonen, Annelies; https://orcid.org/0000-0003-0682-9533, de Souza, Savia, de Thurah, Annette; https://orcid.org/0000-0003-0103-4328, Dorner, Thomas E, Moe, Rikke Helene; https://orcid.org/0000-0001-7601-5346, Putrik, Polina, Rodríguez-Carrio, Javier; https://orcid.org/0000-0002-0011-5102, Silva-Fernández, Lucía, Stamm, Tanja; https://orcid.org/0000-0003-3073-7284, Walker-Bone, Karen, Welling, Joep, Zlatković-Švenda, Mirjana I; https://orcid.org/0000-0002-7123-140X, Guillemin, Francis; https://orcid.org/0000-0002-9860-7024, Verstappen, Suzanne M M, Gwinnutt, James M; https://orcid.org/0000-0002-1435-8797, Wieczorek, Maud; https://orcid.org/0000-0002-4528-9923, Cavalli, Giulio; https://orcid.org/0000-0001-8728-3004, Balanescu, Andra, Bischoff-Ferrari, Heike A, Boonen, Annelies; https://orcid.org/0000-0003-0682-9533, de Souza, Savia, de Thurah, Annette; https://orcid.org/0000-0003-0103-4328, Dorner, Thomas E, Moe, Rikke Helene; https://orcid.org/0000-0001-7601-5346, Putrik, Polina, Rodríguez-Carrio, Javier; https://orcid.org/0000-0002-0011-5102, Silva-Fernández, Lucía, Stamm, Tanja; https://orcid.org/0000-0003-3073-7284, Walker-Bone, Karen, Welling, Joep, Zlatković-Švenda, Mirjana I; https://orcid.org/0000-0002-7123-140X, Guillemin, Francis; https://orcid.org/0000-0002-9860-7024, and Verstappen, Suzanne M M

Abstract

Background: A European League Against Rheumatism (EULAR) taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). This paper reviews the literature on the effects of physical exercise and body weight on disease-specific outcomes of people with RMDs. Methods: Three systematic reviews were conducted to summarise evidence related to exercise and weight in seven RMDs: osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis (axSpA), psoriatic arthritis, systemic sclerosis and gout. Systematic reviews and original studies were included if they assessed exercise or weight in one of the above RMDs, and reported results regarding disease-specific outcomes (eg, pain, function, joint damage). Systematic reviews were only included if published between 2013-2018. Search strategies were implemented in the Medline, Embase, Cochrane Library of systematic reviews and CENTRAL databases. Results: 236 articles on exercise and 181 articles on weight were included. Exercise interventions resulted in improvements in outcomes such as pain and function across all the RMDs, although the size of the effect varied by RMD and intervention. Disease activity was not influenced by exercise, other than in axSpA. Increased body weight was associated with worse outcomes for the majority of RMDs and outcomes assessed. In general, study quality was moderate for the literature on exercise and body weight in RMDs, although there was large heterogeneity between studies. Conclusion: The current literature supports recommending exercise and the maintenance of a healthy body weight for people with RMDs. Keywords: arthritis; epidemiology; patient reported outcome measures; physical therapy modalities

Published
2022

86. P187 Pre-defined Gene Co-expression Modules in Rheumatoid Arthritis Transition towards Molecular Health following Tumour Necrosis Factor Inhibitor Therapy

Author

Sutcliffe, Megan A, primary, Nair, Nisha, additional, Oliver, James, additional, Morgan, Ann, additional, Isaacs, John, additional, Wilson, Gerry, additional, Verstappen, Suzanne, additional, Viatte, Sebastien, additional, Hyrich, Kimme, additional, Morris, Andrew, additional, Barton, Anne, additional, and Plant, Darren, additional

Published
2022
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87. Pre-defined gene co-expression modules in rheumatoid arthritis transition towards molecular health following anti-TNF therapy

Author

Sutcliffe, Megan, primary, Nair, Nisha, additional, Oliver, James, additional, Morgan, Ann W, additional, Isaacs, John D, additional, Wilson, Anthony G, additional, Verstappen, Suzanne M M, additional, Viatte, Sebastien, additional, Hyrich, Kimme L, additional, Morris, Andrew P, additional, Barton, Anne, additional, and Plant, Darren, additional

Published
2022
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88. Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis

Author

Gwinnutt, James M, primary, Norton, Sam, additional, Hyrich, Kimme L, additional, Lunt, Mark, additional, Combe, Bernard, additional, Rincheval, Nathalie, additional, Ruyssen-Witrand, Adeline, additional, Fautrel, Bruno, additional, McWilliams, Daniel F, additional, Walsh, David A, additional, Nikiphorou, Elena, additional, Kiely, Patrick D W, additional, Young, Adam, additional, Chipping, Jacqueline R, additional, MacGregor, Alex, additional, and Verstappen, Suzanne M M, additional

Published
2022
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89. 2021 EULAR recommendations regarding lifestyle behaviours and work participation to prevent progression of rheumatic and musculoskeletal diseases

Author

Gwinnutt, James M, primary, Wieczorek, Maud, additional, Balanescu, Andra, additional, Bischoff-Ferrari, Heike A, additional, Boonen, Annelies, additional, Cavalli, Giulio, additional, de Souza, Savia, additional, de Thurah, Annette, additional, Dorner, Thomas E, additional, Moe, Rikke Helene, additional, Putrik, Polina, additional, Rodríguez-Carrio, Javier, additional, Silva-Fernández, Lucía, additional, Stamm, Tanja, additional, Walker-Bone, Karen, additional, Welling, Joep, additional, Zlatković-Švenda, Mirjana I, additional, Guillemin, Francis, additional, and Verstappen, Suzanne M M, additional

Published
2022
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90. Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (RMDs): systematic reviews and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs

Author

Gwinnutt, James M, primary, Wieczorek, Maud, additional, Cavalli, Giulio, additional, Balanescu, Andra, additional, Bischoff-Ferrari, Heike A, additional, Boonen, Annelies, additional, de Souza, Savia, additional, de Thurah, Annette, additional, Dorner, Thomas E, additional, Moe, Rikke Helene, additional, Putrik, Polina, additional, Rodríguez-Carrio, Javier, additional, Silva-Fernández, Lucía, additional, Stamm, Tanja, additional, Walker-Bone, Karen, additional, Welling, Joep, additional, Zlatković-Švenda, Mirjana I, additional, Guillemin, Francis, additional, and Verstappen, Suzanne M M, additional

Published
2022
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91. Smoking, alcohol consumption and disease-specific outcomes in rheumatic and musculoskeletal diseases (RMDs): systematic reviews informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs

Author

Wieczorek, Maud, primary, Gwinnutt, James Martin, additional, Ransay-Colle, Maxime, additional, Balanescu, Andra, additional, Bischoff-Ferrari, Heike, additional, Boonen, Annelies, additional, Cavalli, Giulio, additional, de Souza, Savia, additional, de Thurah, Annette, additional, Dorner, Thomas Ernst, additional, Moe, Rikke Helene, additional, Putrik, Polina, additional, Rodríguez-Carrio, Javier, additional, Silva-Fernández, Lucía, additional, Stamm, Tanja A, additional, Walker-Bone, Karen, additional, Welling, Joep, additional, Zlatkovic-Svenda, Mirjana, additional, Verstappen, Suzanne MM, additional, and Guillemin, Francis, additional

Published
2022
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96. Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization.

Author

Zhao, Sizheng Steven, Bellou, Eftychia, Verstappen, Suzanne M M, Cook, Michael J, Sergeant, Jamie C, Warren, Richard B, Barton, Anne, and Bowes, John

Subjects
PSORIASIS, LIFESTYLES, PSORIATIC arthritis, RESEARCH evaluation, GENETICS, SCIENTIFIC observation, TISSUE banks, CONFIDENCE intervals, CROSS-sectional method, AGE distribution, DIABETES, RISK assessment, SEX distribution, SOCIOECONOMIC factors, CORONARY artery disease, GENOMES, BODY mass index, SMOKING, PROSTATE-specific antigen, LOGISTIC regression analysis, ODDS ratio, COMORBIDITY, DISEASE risk factors
Abstract

Objectives To examine associations between PsA and psoriasis vs lifestyle factors and comorbidities by triangulating observational and genetic evidence. Methods We analysed cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, 36 000 controls) to describe the association between psoriatic disease and lifestyle factors (including BMI and smoking) and 15 comorbidities [including diabetes and coronary artery disease (CAD)] using logistic models adjusted for age, sex and lifestyle factors. We applied bidirectional Mendelian randomization (MR) to genome-wide association data (3609 PsA and 7804 psoriasis cases, up to 1.2 million individuals for lifestyle factors and 757 601 for comorbidities) to examine causal direction, using the inverse-variance weighted method. Results BMI was cross-sectionally associated with risk of PsA (OR 1.31 per 5 kg/m2 increase; 95% CI 1.26, 1.37) and psoriasis (OR 1.23; 1.20, 1.26), with consistent MR estimates (PsA OR 1.38; 1.14, 1.67; psoriasis OR 1.36; 1.18, 1.58). In both designs, smoking was more strongly associated with psoriasis than PsA. PsA and psoriasis were cross-sectionally associated with diabetes (OR 1.35 and 1.39, respectively) and CAD (OR 1.56 and 1.38, respective). Genetically predicted glycated haemoglobin (surrogate for diabetes) increased PsA risk (OR 1.18 per 6.7 mmol/mol increase; 1.02, 1.36) but not psoriasis. Genetic liability to PsA (OR 1.05; 1.003, 1.09) and psoriasis (OR 1.03; 1.001, 1.06) were associated with increased risk of CAD. Conclusion Observational and genetic evidence converge to suggest that BMI and glycaemic control are associated with increased psoriatic disease risk, while psoriatic disease is associated with increased CAD risk. Further research is needed to understand the mechanism of these associations. [ABSTRACT FROM AUTHOR]

Published
2023
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100. Using epidemiological registry data to provide background rates as context for adverse events in a rheumatoid arthritis drug development program: a coordinated approach‡

Author

Nyberg, Fredrik, Askling, Johan, Berglind, Niklas, Franzén, Stefan, Ho, Meilien, Holmqvist, Marie, Horne, Laura, Lampl, Kathy, Michaud, Kaleb, Pappas, Dimitrios A., Reed, George, Symmons, Deborah, Tanaka, Eiichi, Tran, Trung N., Verstappen, Suzanne M. M., Wesby-van Swaay, Eveline, Yamanaka, Hisashi, and Greenberg, Jeffrey D.

Published
2015
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