51. Lesion load may predict long-term cognitive dysfunction in multiple sclerosis patients
- Author
-
Gioacchino Tedeschi, Sabrina Realmuto, Damiano Paolicelli, Giovanni Savettieri, Vincenzo Brescia Morra, Alessandro d’Ambrosio, Silvia Messina, Veria Vacchiano, Mario Zappia, Maria Buccafusca, Bruno Alfano, Roberta Lanzillo, Domenico Ippolito, Paola Valentino, Antonio Gallo, Luigi Lavorgna, Manuela De Stefano, Francesco Patti, Rosa Gemma Viterbo, Patrizia Montella, Isabella Laura Simone, Clara Grazia Chisari, G. Coniglio, Simona Bonavita, Patti, F, De Stefano, M, Lavorgna, L, Messina, S, Chisari, C. G, Ippolito, D, Lanzillo, Roberta, Vacchiano, V, Realmuto, S, Valentino, P, Coniglio, G, Buccafusca, M, Paolicelli, D, D'Ambrosio, A, Montella, P, BRESCIA MORRA, Vincenzo, Savettieri, Giovanni, Alfano, B, Gallo, A, Simone, I, Viterbo, R, Zappia, M, Bonavita, S, Tedeschi, G., Chisari, Cg, Lanzillo, R, D'Ambrosio, Alessandro, Brescia Morra, V, Savettieri, G, Gallo, Antonio, Bonavita, Simona, Tedeschi, Gioacchino, Patti, F., De Stefano, M., Lavorgna, L., Messina, S., Chisari, C., Ippolito, D., Lanzillo, R., Vacchiano, V., Realmuto, S., Valentino, P., Coniglio, G., Buccafusca, M., Paolicelli, D., D'Ambrosio, A., Montella, P., Brescia Morra, V., Savettieri, G., Alfano, B., Gallo, A., Simone, I., Viterbo, R., Zappia, M., and Bonavita, S.
- Subjects
EMTREE medical terms: Article ,recall ,lcsh:Medicine ,Audiology ,Neuropsychological Tests ,Nerve Fibers, Myelinated ,030218 nuclear medicine & medical imaging ,Cohort Studies ,0302 clinical medicine ,cognitive defect ,nuclear magnetic resonance imaging ,lcsh:Science ,Modified Card Sorting Test ,Multidisciplinary ,neuroimaging ,Semantically Related Word List Test ,Multiple Sclerosis, Cognitive Dysfunction, MRI ,medicine.diagnostic_test ,predictive value ,Brain ,Cognition ,Neuropsychological test ,gray matter ,Middle Aged ,Prognosis ,Magnetic Resonance Imaging ,Memory, Short-Term ,female ,brain size ,multiple sclerosi ,Cohort ,Disease Progression ,Settore MED/26 - Neurologia ,white matter ,Research Article ,Adult ,medicine.medical_specialty ,Multiple Sclerosis ,Paced Auditory Serial Addition Test ,verbal memory ,cerebrospinal fluid ,working memory ,03 medical and health sciences ,male ,medicine ,Humans ,controlled study ,human ,Recall ,business.industry ,Multiple sclerosis ,lcsh:R ,Magnetic resonance imaging ,medicine.disease ,major clinical study ,attention ,executive function ,Symbol Digit Modalities Test ,neuropsychological test ,lcsh:Q ,Verbal memory ,business ,Cognition Disorders ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Background: Magnetic Resonance Imaging (MRI) techniques provided evidences into the understanding of cognitive impairment (CIm) in Multiple Sclerosis (MS). Objectives: To investigate the role of white matter (WM) and gray matter (GM) in predicting long-term CIm in a cohort of MS patients. Methods: 303 out of 597 patients participating in a previous multicenter clinical-MRI study were enrolled (49.4% were lost at follow-up). The following MRI parameters, expressed as fraction (f) of intracranial volume, were evaluated: cerebrospinal fluid (CSF-f), WM-f, GM-f and abnormal WM (AWM-f), a measure of lesion load. Nine years later, cognitive status was assessed in 241 patients using the Symbol Digit Modalities Test (SDMT), the Semantically Related Word List Test (SRWL), the Modified Card Sorting Test (MCST), and the Paced Auditory Serial Addition Test (PASAT). In particular, being SRWL a memory test, both immediate recall and delayed recall were evaluated. MCST scoring was calculated based on the number of categories, number of perseverative and non-perseverative errors. Results: AWM-f was predictive of an impaired performance 9 years ahead in SDMT (OR 1.49, CI 1.12-1.97 p = 0.006), PASAT (OR 1.43, CI 1.14-1.80 p = 0.002), SRWL-immediate recall (OR 1.72 CI 1.35-2.20 p
- Published
- 2015