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55. New Parameter for the evaluation of disgnathic patient's surgical planning: a preliminary report

Author

Filiaci, F., Ramieri, V., Fatone, F. M. G., PAOLO GENNARO, Arangio, P., Rinna, C., Vellone, V., Agrillo, A., Ungari, C., and Cascone, P.

Subjects
familiarity, Cephalometry, Clinical evaluation, Familiarity, Maxillo-mandibular malformation, Medicine (all), Pharmacology (medical), Esthetics, Patient Satisfaction, clinical evaluation, Humans, cephalometry, Mandibular Reconstruction, maxillo-mandibular malformation
Abstract

Indications for treatment of patients with maxillo-mandibular malformations have to be researched both in the severity of anatomical alteration affecting the face and psychological outcomes. Indeed, it has been underlined that patients decide to undergo orthodontic and orthognathic procedure mainly for aesthetical issues. Moreover the early combined functional and surgical treatment improves relationship skills in young adults. Dealing with these "aesthetic" features pre surgical planning presents some additional challenges. Even if orthognatic surgery aims to the correct repositioning of skeletal bases but we must achieve complete patient satisfaction.The Authors present a new parameter to be considered in the planning of patients who undergo orthognatic procedure being the restitution of the face the patient would have had without any pathologic mechanism with respect of the aesthetic features of the family.Authors identified a series of parameters discussed by Arnett et al and performed a clinical and photographic evaluation of these parameters, in latero-lateral view, directly on the relatives of the patients. A cephalometric analysis, was performed and a series of parameters has been taken into account.It is very difficult to standardize universal parameters acceptable and applicable for every single case, considering that patient's awareness of the anatomical defect and post-surgical satisfaction don't relate to the correct cephalometric evaluation and the real aesthetic outcomes.

Published
2012

63. 265 TESTICULAR DEGENERATION AFFECTED PLASMA, ACROSOMAL AND MITOCHONDRIAL MEMBRANE INTEGRITY, AND DNA FRAGMENTATION IN RAM SPERMATOZOA

Author

Bianchi Rodrigues Alves, M., primary, Furugen Cesar de Andrade, A., additional, Paes de Arruda, R., additional, Batissaco, L., additional, Lançoni, R., additional, Andrade Torres, M., additional, Mouro Ravagnani, G., additional, Florez-Rodriguez, S. A., additional, Marcelle Martins de Oliveira, B., additional, Vellone, V., additional, and Carla Carvalho Celeghini, E., additional

Published
2015
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66. Survivin protein as predictor of pathologic response in patients with locally advanced cervical cancer treated with chemoradiation followed by radical surgery

Author

Zannoni, Gian Franco, Petrillo, M, Vellone, V, Martinelli, E, Chiarello, G, Ferrandina, Maria Gabriella, Scambia, Giovanni, Zannoni, G (ORCID:0000-0003-1809-129X), Ferrandina, Maria Gabriella (ORCID:0000-0003-4672-4197), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Zannoni, Gian Franco, Petrillo, M, Vellone, V, Martinelli, E, Chiarello, G, Ferrandina, Maria Gabriella, Scambia, Giovanni, Zannoni, G (ORCID:0000-0003-1809-129X), Ferrandina, Maria Gabriella (ORCID:0000-0003-4672-4197), and Scambia, Giovanni (ORCID:0000-0003-2758-1063)

Abstract

We investigated the correlation of pathologic response and immunohistochemically assessed expression of survivin protein in 71 patients with locally advanced cervical cancer treated with chemoradiation (CT/RT) followed by radical surgery. The prognostic role of survivin expression was also evaluated. Immunohistochemical analysis of survivin expression was carried out using the polyclonal rabbit antisurvivin antibody. Cytoplasmic survivin immunoreaction was observed in 69 (97.2%) of 71 cases and nuclear staining in 7 (9.8%) of 71 women. Median cytoplasmic survivin expression was 160 (range, 0-280), and higher levels were observed in patients with residual disease (≥3 mm) in the cervix (survivin level, 160 versus 120; P = .016) and in women with metastatic lymph nodes (survivin levels, 160 versus 150; P = .032). No differences were documented in the distribution of patients with positive nuclear staining, according to clinicopathological variables. In multivariate analysis, cytoplasmic survivin expression emerged as an independent predictor of residual cervical disease and lymph node status after CT/RT. During a follow-up period of 83 months (range, 8-175 months), recurrences occurred in 24 (33.8%) women, and all patients died of disease. Women with high cytoplasmic survivin experienced shorter disease-free survival compared with patients with low levels (5-year disease-free survival, 80.8% versus 55.3%; P = .033). Only a trend was observed for greater overall survival in patients with high expression (5-year overall survival, 81.0% versus 55.3%; P = .069). No survival differences were documented for nuclear survivin status. The immunohistochemically assessed survivin cytoplasmic levels at diagnosis represent a reliable and easily assessable tool to predict response to CT/RT in patients with locally advanced cervical cancer.

Published
2014

72. Magnetic resonance enema vs rectal water-contrast transvaginal sonography in diagnosis of rectosigmoid endometriosis.

Author

Leone Roberti Maggiore, U., Biscaldi, E., Vellone, V. G., Venturini, P. L., and Ferrero, S.

Subjects
TRANSVAGINAL ultrasonography, MAGNETIC resonance imaging, DIAGNOSIS of endometriosis, SIGMOID colon, LAPAROSCOPIC surgery, DISEASES, COMPARATIVE studies, ENDOMETRIOSIS, ENEMA, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, RESEARCH, ULTRASONIC imaging, VAGINA, WATER, EVALUATION research, CONTRAST media
Abstract

Objective: To compare the accuracy of magnetic resonance enema (MR-e) and rectal water-contrast transvaginal sonography (RWC-TVS) in the diagnosis of rectosigmoid endometriosis.Methods: This prospective study included 286 patients of reproductive age with clinical suspicion of rectosigmoid endometriosis. Patients underwent MR-e and RWC-TVS before laparoscopic excision of endometriotic lesions. The findings of MR-e and RWC-TVS were compared with surgical and histological results.Results: Of the 286 patients included in the study, 151 (52.8%) had rectosigmoid endometriosis. MR-e and RWC-TVS had similar accuracy in the diagnosis of rectosigmoid endometriosis (P = 0.063). In the diagnosis of rectosigmoid endometriosis with MR-e, the sensitivity was 95.4% (95% CI, 90.7-99.1%), specificity was 97.8% (95% CI, 93.6-99.5%), positive predictive value (PPV) was 98.0% (95% CI, 94.1-99.6%), negative predictive value (NPV) was 95.0% (95% CI, 89.9-97.9%), positive likelihood ratio (LR+) was 42.91 (95% CI, 14.01-131.46) and negative likelihood ratio (LR-) was 0.05 (95% CI, 0.02-0.10). For diagnosis with RWC-TVS, sensitivity was 92.7% (95% CI, 87.3-96.3%), specificity was 97.0% (95% CI, 92.6-99.2%), PPV was 97.2% (95% CI, 93.0-99.2%), NPV was 92.3% (95% CI, 86.6-96.1%), LR+ was 31.29 (95% CI, 11.90-82.25) and LR- was 0.08 (95% CI, 0.04-0.13). MR-e and RWC-TVS underestimated the size of the endometriotic nodules; for both imaging techniques the underestimation was greater for nodules with a diameter ≥ 30 mm. There was no significant difference in the mean intensity of pain experienced by the patients during the two examinations.Conclusions: RWC-TVS should be the first-line investigation in patients with clinical suspicion of rectosigmoid endometriosis and physicians should be trained in performing this examination. Considering that MR-e is more expensive than RWC-TVS, it should be used only when the findings of RWC-TVS are unclear. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]

Published
2017
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73. Computed tomographic colonography vs rectal water- contrast transvaginal sonography in diagnosis of rectosigmoid endometriosis: a pilot study.

Author

Ferrero, S., Biscaldi, E., Vellone, V. G., Venturini, P. L., and Leone Roberti Maggiore, U.

Subjects
DIAGNOSIS of endometriosis, VIRTUAL colonoscopy, TRANSVAGINAL ultrasonography, LAPAROSCOPY, STENOSIS, COMPARATIVE studies, ENDOMETRIOSIS, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, RESEARCH, ULTRASONIC imaging, VAGINA, WATER, PILOT projects, EVALUATION research, CONTRAST media
Abstract

Objectives: To compare the performance of computed tomographic colonography (CTC) and rectal water-contrast transvaginal sonography (RWC-TVS) in the diagnosis of rectosigmoid endometriosis, and compare precision in estimating the length of the rectosigmoid nodules and the distance between the nodules and the anal verge.Methods: This prospective study included 70 patients of reproductive age with clinical suspicion of rectosigmoid endometriosis. Patients underwent RWC-TVS and CTC before laparoscopic excision of endometriotic nodules. The findings of RWC-TVS and CTC were compared with surgical and histological results.Results: Of the 70 patients included in the study, 40 (57.1%) had rectosigmoid endometriosis. CTC and RWC-TVS had similar accuracy in the diagnosis of rectosigmoid endometriosis (P = 0.508) and similar precision in estimating the length of the endometriotic nodules (P = 0.077). CTC was more precise than RWC-TVS in estimating the distance between the rectosigmoid nodule and the anal verge (P < 0.001). The intensity of pain experienced during CTC was higher than that perceived during RWC-TVS (P < 0.001); however, intestinal distension for CTC was well-tolerated in all patients without significant adverse effects.Conclusions: RWC-TVS and CTC have similar accuracy in the diagnosis of rectosigmoid endometriosis and similar precision in estimating the size of the nodules; however, CTC is more precise than RWC-TVS in estimating the distance between the nodules and the anal verge, yet patients tolerate RWC-TVS better than CTC. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]

Published
2017
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76. Follicular loss in endoscopic surgery for ovarian endometriosis: quantitative and qualitative observations

Author

Romualdi, Daniela, Franco Zannoni, G, Lanzone, Antonio, Selvaggi, Luigi, Tagliaferri, Valeria, Gaetano Vellone, V, Campagna, Giuseppe, Guido, Maurizio, Lanzone, Antonio (ORCID:0000-0003-4119-414X), Guido, Maurizio (ORCID:0000-0001-6554-0874), Romualdi, Daniela, Franco Zannoni, G, Lanzone, Antonio, Selvaggi, Luigi, Tagliaferri, Valeria, Gaetano Vellone, V, Campagna, Giuseppe, Guido, Maurizio, Lanzone, Antonio (ORCID:0000-0003-4119-414X), and Guido, Maurizio (ORCID:0000-0001-6554-0874)

Abstract

To identify a possible marker of follicular depletion in relation to some histologic parameters of endometriotic cysts.

Published
2011

77. Prognostic significance of the Ki-67 labeling index in growth hormone-secreting pituitary adenomas.

Author

Fusco, Alessandra, Zatelli, Mc, Bianchi, Antonio, Cimino, V, Tilaro, Laura, Veltri, Flora, Angelini, F, Lauriola, Libero, Vellone, V, Doglietto, Francesco, Ambrosio, Mr, Maira, Giulio, Giustina, A, Degli Uberti, Ec, Pontecorvi, Alfredo, De Marinis, Laura, Lauriola, Libero (ORCID:0000-0003-0481-5138), Doglietto, Francesco (ORCID:0000-0002-7438-0734), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), De Marinis, Laura (ORCID:0000-0001-9916-0669), Fusco, Alessandra, Zatelli, Mc, Bianchi, Antonio, Cimino, V, Tilaro, Laura, Veltri, Flora, Angelini, F, Lauriola, Libero, Vellone, V, Doglietto, Francesco, Ambrosio, Mr, Maira, Giulio, Giustina, A, Degli Uberti, Ec, Pontecorvi, Alfredo, De Marinis, Laura, Lauriola, Libero (ORCID:0000-0003-0481-5138), Doglietto, Francesco (ORCID:0000-0002-7438-0734), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), and De Marinis, Laura (ORCID:0000-0001-9916-0669)

Abstract

CONTEXT: Ki-67 is a marker of proliferation activity associated with invasiveness and prognosis in human tumors. OBJECTIVE: The aim of the study was to evaluate the Ki-67 index prognostic relevance in a group of acromegalic patients who underwent transsphenoidal surgery for a GH-secreting pituitary adenoma. MATERIAL AND METHODS: We selected 68 consecutive acromegalic patients referred to our hospital during a 5-yr period. The Ki-67 index was determined by immunohistochemistry on tissue samples obtained from each adenoma after surgery. Those patients who were not completely cured after surgery began medical therapy with somatostatin analogs (SSAs). Periodical pituitary magnetic resonance imaging and hormonal evaluation were performed during the follow-up. RESULTS: Twenty-eight of 68 patients were cured after surgery (41%). Among the 40 patients treated with SSAs, 13 were considered uncontrolled. Pituitary magnetic resonance imaging showed residual/recurrent disease in 25 of 68 patients after 6 months. No correlation was found between Ki-67 index and age, tumor size, GH, or IGF-I plasma levels. Tumors described as having cavernous sinus invasion had a higher mean Ki-67 index as compared with noninvasive tumors (P < 0.01). The Ki-67 index was significantly lower in tumors in patients cured after surgery as compared with patients considered not cured (P < 0.01) and in tumors in patients controlled by SSA therapy as compared with patients considered as uncontrolled (P < 0.05). CONCLUSION: The Ki-67 labeling index may predict clinical outcome in postsurgical management of acromegalic patients. We suggest routine Ki-67 evaluation in GH-secreting pituitary adenomas.

Published
2008

79. HPV infection in squamous cell carcinomas arising from different mucosal sites of the head and neck region. Is p16 immunohistochemistry a reliable surrogate marker?

Author

Bussu, F, primary, Sali, M, additional, Gallus, R, additional, Vellone, V G, additional, Zannoni, G F, additional, Autorino, R, additional, Dinapoli, N, additional, Santangelo, R, additional, Martucci, R, additional, Graziani, C, additional, Miccichè, F, additional, Almadori, G, additional, Galli, J, additional, Delogu, G, additional, Sanguinetti, M, additional, Rindi, G, additional, Valentini, V, additional, and Paludetti, G, additional

Published
2013
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80. Solitary choroid plexus tuberculoma in an adult patient. Case illustration

Author

Doglietto, Francesco, Marchese, Enrico, Puca, A., Vellone, V. G., Tirpakova, B., Sanguinetti, Maurizio, Doglietto F. (ORCID:0000-0002-7438-0734), Marchese E. (ORCID:0000-0001-8551-0357), Sanguinetti M. (ORCID:0000-0002-9780-7059), Doglietto, Francesco, Marchese, Enrico, Puca, A., Vellone, V. G., Tirpakova, B., Sanguinetti, Maurizio, Doglietto F. (ORCID:0000-0002-7438-0734), Marchese E. (ORCID:0000-0001-8551-0357), and Sanguinetti M. (ORCID:0000-0002-9780-7059)

Abstract

Solitary choroid plexus tuberculoma in an adult patient. Case illustration

Published
2006

84. Posters * Endometriosis, Endometrium and Implantation

Author

Jiang, Y., primary, Zhao, J., additional, Hua, M., additional, Zhen, X., additional, Yan, G., additional, Hu, Y., additional, Sun, H., additional, Selvaggi, L., additional, Zannoni, G. F., additional, Tagliaferri, V., additional, De Cicco, S., additional, Vellone, V. G., additional, Romualdi, D., additional, Lanzone, A., additional, Guido, M., additional, Fassbender, A., additional, Vodolazkaia, A. V., additional, Bossuyt, X. B., additional, Kyama, M. K., additional, Meuleman, C. M., additional, Peeraer, K. P., additional, Tomassetti, C. T., additional, D'Hooghe, T. M., additional, Lumini, A., additional, Nanni, L., additional, Manna, C., additional, Pappalardo, S., additional, Melin, A., additional, Lundholm, C., additional, Malki, N., additional, Swahn, M. L., additional, Sparen, P., additional, Bergqvist, A., additional, Crescenzi, F., additional, Farrag, A., additional, Sallam, H. N., additional, Zou, L., additional, Ding, G., additional, Zhang, R., additional, Sheng, J., additional, Huang, H., additional, von Kleinsorgen, C., additional, Wilson, T., additional, Thiel-Moder, U., additional, Ebert, A. D., additional, Reinfandt, M., additional, Papadopolous, T., additional, Melo, A. S., additional, Rodrigues, J. K., additional, Dib, L. A., additional, Andrade, A. Z., additional, Donabela, F. C., additional, Ferriani, R. A., additional, Navarro, P. A., additional, Tocci, A., additional, Royo, P., additional, Lucchini, C., additional, Ramos, P., additional, Alcazar, J. L., additional, Habara, T., additional, Terada, S., additional, Yoshioka, N., additional, Hayashi, N., additional, Haouzi, D., additional, Assou, S., additional, Monzo, C., additional, Anahory, T., additional, Dechaud, H., additional, De Vos, J., additional, Hamamah, S., additional, Gonzalez-Ramos, R., additional, Rojas, C., additional, Rocco, J., additional, Poch, A., additional, Sovino, H., additional, Kohen, P., additional, Munoz, A., additional, Devoto, L., additional, Aygen, M. A., additional, Atakul, T., additional, Oner, G., additional, Ozgun, M. T., additional, Sahin, Y., additional, Ozturk, F., additional, Li, R., additional, Qiao, J., additional, Zhylkova, I., additional, Feskov, A., additional, Feskova, I., additional, Somova, O., additional, Chumakova, N., additional, Bontekoe, S., additional, Blake, D., additional, Heineman, M. J., additional, Williams, E. C., additional, Johnson, N. P., additional, Motta, A., additional, Colaci, D., additional, Horton, M., additional, Faut, M., additional, Bisioli, C., additional, Kopcow, L., additional, de Zuniga, I., additional, Wiener-Megnazi, Z., additional, Khaytov, M., additional, Lahav - Baratz, S., additional, Shiloh, H., additional, Koifman, M., additional, Oslander, R., additional, Dirnfeld, M., additional, Sundqvist, J., additional, Andersson, K. L., additional, Scarselli, G., additional, Gemzell-Danielsson, K., additional, Lalitkumar, P. G. L., additional, Tokushige, N., additional, Markham, R., additional, Crossett, B., additional, Ahn, S., additional, Nelaturi, V., additional, Khan, A., additional, Fraser, I. S., additional, Van Vaerenbergh, I., additional, Fatemi, H. M., additional, Blockeel, C., additional, Van Lommel, L., additional, In't Veld, P., additional, Schuit, F., additional, Kolibianakis, E. M., additional, Devroey, P., additional, Bourgain, C., additional, Sugino, N., additional, Tamura, I., additional, Lee, R., additional, Maekawa, R., additional, Gelbaya, T., additional, Gordts, S., additional, D'Hooghe, T. N., additional, Gergolet, M., additional, Nardo, L. G., additional, Yu, H., additional, Wang, H., additional, Lee, C., additional, Soong, Y., additional, Kremenska, Y., additional, Masliy, Y., additional, Goncharova, Y., additional, Kremenskoy, M., additional, Veselovskyy, V., additional, Zukin, V., additional, Sudoma, I., additional, Delgado-Rosas, F., additional, Gomez, R., additional, Tamarit, S., additional, Abad, A., additional, Simon, C., additional, Pellicer, A., additional, Racicot, M., additional, Dean, N. L., additional, Antaki, R., additional, Menard, S., additional, Kadoch, I. J., additional, Garcia-Guzman, R., additional, Cabrera Romero, L., additional, Hernandez, J., additional, Palumbo, A., additional, Marshall, E., additional, Lowry, J., additional, Maybin, J. A., additional, Collins, F., additional, Critchley, H. O. D., additional, Saunders, P. T. K., additional, Chaudhury, K., additional, Jana, S. K., additional, Banerjee, P., additional, Mukherjee, S., additional, Chakravarty, B. N., additional, Allegra, A., additional, Marino, A., additional, Lama, A., additional, Santoro, A., additional, Agueli, C., additional, Mazzola, S., additional, Volpes, A., additional, Delvoux, B., additional, de Graaff, A. A., additional, Kyama, C. M., additional, Dunselman, G. A. J., additional, Romano, A., additional, Caccavo, D., additional, Pellegrino, N. M., additional, Totaro, I., additional, Panzarino, M., additional, Nardelli, C., additional, Depalo, R., additional, Flores, R., additional, Montanana, V., additional, Monzo, A., additional, Polo, P., additional, Garcia-Gimeno, T., additional, Cabo, A., additional, Rubio, J. M., additional, Beets, G. L., additional, van Lankveld, J. J., additional, Kim, H. Y., additional, Lee, B. S., additional, Cho, S. H., additional, Choi, Y. S., additional, Seo, S. K., additional, Lee, K. E., additional, Yang, H. I., additional, Abubakirov, A., additional, Vacheyshvili, T., additional, Krechetova, L., additional, Ziganshina, M., additional, Demura, T., additional, Nazarenko, T., additional, Fulop, I., additional, Rucz, A., additional, Herczegh, S. Z., additional, Ujvari, A., additional, Takacs, S. Z., additional, Szakonyi, T., additional, Lopez - Muniz, A., additional, Zamora, L., additional, Serra, O., additional, Guix, C., additional, Lopez-Teijon, M., additional, Benadiva, C., additional, Alvarez, J. G., additional, Goudakou, M., additional, Karkanaki, A., additional, Kalogeraki, A., additional, Mataliotakis, I., additional, Kalogiannidis, I., additional, Prapas, I., additional, Hosie, M., additional, Thomson, K. J., additional, Penny, C. B., additional, Penny, C., additional, Hosie, M. J., additional, McKinnon, B., additional, Klaeser, B., additional, Bersinger, N., additional, Mueller, M. D., additional, Horcajadas, J. A., additional, Martinez-Conejero, J. A., additional, Montesinos, M., additional, Morgan, M., additional, Fortuno, S., additional, Yi, K. W., additional, Shin, J. H., additional, Park, H. T., additional, Kim, T., additional, Kim, S. H., additional, Hur, J. Y., additional, Chan, R. W. S., additional, Chan, Y. Y., additional, Ng, E. H. Y., additional, Yeung, W. S. B., additional, Santulli, P., additional, Borghese, B., additional, Chopin, N., additional, Marcellin, L., additional, de Ziegler, D., additional, Chapron, C., additional, Elnashar, A., additional, Badawy, A., additional, Mosbah, A., additional, Tzioras, S., additional, Polyzos, N. P., additional, Messini, C. I., additional, Papanikolaou, E. G., additional, Valachis, A., additional, Patavoukas, E., additional, Mauri, D., additional, Messinis, I. E., additional, Acar, N., additional, Hirota, Y., additional, Tranguch, S., additional, Daikoku, T., additional, Burnum, K. E., additional, Xie, H., additional, Kodama, A., additional, Osuga, Y., additional, Ustunel, I., additional, Friedman, D. B., additional, Caprioli, R. M., additional, Dey, S. K., additional, Mitra, A., additional, Sahu, R., additional, Pal, M., additional, Bhattachrayya, A. K., additional, Bhattachrya, J., additional, Ferrero, S., additional, Remorgida, V., additional, Rollandi, G. A., additional, Biscaldi, E., additional, Cho, S., additional, Arena, E., additional, Morando, A., additional, Tomazevic, T., additional, Ban-Frangez, H., additional, Virant-Klun, I., additional, Verdenik, I., additional, Pozlep, B., additional, Vrtacnik-Bokal, E., additional, Valenzano Menada, M., additional, Morotti, M., additional, Venturini, P. L., additional, Dimitriadis, E., additional, Salamonsen, L. A., additional, Hannan, N., additional, O'Connor, O., additional, Rombauts, L., additional, Stoikos, C., additional, Mahmoudi, M., additional, Shaikh, A., additional, Mousavifar, N., additional, Rastin, M., additional, Baharara, J., additional, Tabasi, N., additional, Takemura, Y., additional, Fujimoto, A., additional, Tsutsumi, R., additional, Ooi, N., additional, Yano, T., additional, Taketani, Y., additional, Panagiotidis, I., additional, Prapas, Y., additional, Zhang, D., additional, Lv, P. P., additional, Ding, G. L., additional, Zhang, R. J., additional, Zou, L. B., additional, Xu, G. F., additional, Gao, H. J., additional, Zhu, Y. M., additional, Sheng, J. Z., additional, Huang, H. F., additional, Labarta, E., additional, Alama, P., additional, and Bosch, E., additional

Published
2010
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85. PA.92 A PROPOSAL MODEL FOR THE NON-INVASIVE ASSESSMENT OF HISTOLOGICAL INFLAMMATION IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

Author

Forgione, A., primary, Miele, L., additional, Cefalo, C., additional, Caprodossi, A., additional, Vellone, V., additional, Racco, S., additional, Gabrieli, M.L., additional, Vero, V., additional, Biolato, M., additional, Vecchio, F.M., additional, Gasbarrini, G., additional, and Grieco, A., additional

Published
2008
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88. Concurrent benign tertiary syphilis and asymptomatic neurosyphilis in an immunocompetent patient.

Author

Cozzani, E., Gasparini, G., Ciccarese, G., Drago, F., Trave, I., Vellone, V., Biatta, C.M., Cabiddu, F., Ribizzi, G., and Parodi, A.

Subjects
SYPHILIS, NEUROSYPHILIS, SEXUALLY transmitted diseases, MYCOSES
Abstract

I Editor i Syphilis is known to be "the great imitator": since the patient's history is often deceiving and the spectrum of clinical signs and symptoms is extremely broad, diagnosis may be particularly challenging.1,2 Tertiary syphilis is rarely seen nowadays but it should be taken into account when dealing with granulomatous disorders of unclear nature.1-4 Indeed, up to 25% of the patients with untreated primary syphilis develop symptoms of tertiary syphilis, usually occurring 3-5 years after primary infection and involving several organs, mainly skin, heart and central nervous system.1 We recently observed an unsuspected case of syphilitic I gummas i in a patient whose history was definitively not evocative for sexually transmitted diseases (STDs). This case was interesting not only for the deceiving patient's history but especially for the clinical aspect of the cutaneous lesions, given the rarity, nowadays, of benign tertiary syphilis ( I gummas) i in clinical practice. CSF testing is crucial for the correct diagnosis and therapeutic approach, also in case of asymptomatic neurosyphilis.6 Even if the patient's history is not evocative for STDs, as in our case, syphilis should be considered when approaching granulomatous lesions of unclear nature. [Extracted from the article]

Published
2021
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89. Neonatal molding in deformational auricolar anomalies.

Author

LEONARDI, A., BIANCA, C., BASILE, E., UNGARI, C., ARANGIO, P., FILIACI, F., PAPOFF, P., VELLONE, V., MORETTI, C., and CASCONE, P.

Abstract

INTRODUCTION: Congenital auricular anomalies can be categorized either as malformational or deformational. The first are characterized by a partial absence of the skin or cartilage resulting in a constricted or underdeveloped pinna and require surgical correction. Deformations are characterized by a misshaped but fully developed pinna and are best treated by auricular molding. AIM: Authors want to present their case load in treatment of infants affected by deformational auricolar anomalies and describe their techniques using early splinting for congenital auricular deformities, like prominent ear, lop ear, constricted ear, Stahl's ear PATIENTS AND METHODS: Between 2009 to 2011, in Maxillo and Oral Surgery Unit, a nonsurgical technique was used to treat 22 ears affected by deformational anomalies in 12 patients soon after birth. Four patients were female. This kind of nonsurgical correction of the deformed auricle was performed on lop ears (n=6), constricted ears (n=8), prominent ears (n= 4), Stahl's ear (n=4). Children more than two months old were also excluded. The mean of treatment time was 5.5 weeks. RESULTS: according to the Authors and the parents 100% of treated auricles improved. Improving at the end of the molding treatment was observed in 18% of the auricles, but recurrence to one year of stopping treatment. There were not complications caused by this procedure. CONCLUSIONS: The nonsurgical molding has the advantage to correct at a very early age a cosmetic abnormality, giving a natural and in the most of the time a satisfactory results, with a prevalence rate of complications of much less than surgical corrections. [ABSTRACT FROM AUTHOR]

Published
2012

94. Mixed malignant mullerian tumor with neuroendocrine features in an irradiated uterus for cervical carcinoma. A unique association? A morphological, immunohistochemisty and ultrastructural study

Author

Vellone, V. G., Spina, B., Grillo, F., Calamaro, P., Sarocchi, F., Sala, P., Simone Ferrero, and Fulcheri, E.

Subjects
Uterine Neoplasms, Uterus, Immunohistochemistry MMMT Neuroendocrine tumor Radio-chemotherapy Ultrastructure, Carcinoma, Squamous Cell, Humans, Mixed Tumor, Mullerian, Uterine Cervical Neoplasms, Female, Hysterectomy, Immunohistochemistry, Aged
Abstract

Chemo-radiation represents an effective therapy for carcinoma of the uterine cervix. The endometrium may however receive a consistent dose of mutagenic radiations and patients may have an increased risk of secondary malignancies. Endometrial mixed malignant mullerian tumor (MMMT) is a rare, highly aggressive disease, and neuroendocrine features are even rarer. A 68 years old woman underwent radio-chemotherapy for a squamous cell carcinoma of the cervix. Follow up was uneventful until, eight years after radio-chemotherapy, imaging exams detected a diffuse enlargement of the uterine body. Radical hysterectomy revealed a multiphasic lesion with both sarcomatous and mixed carcinomatous components. The carcinomatous, component presented neuroendocrine histologic and ultrastuctural features and an intense expression of neuroendocrine immunohistochemistry markers. No residual cervical carcinoma was documented (pR0). The patient died of disease after 9 months. Reported cases further demonstrate how the irradiation of the uterus for cervical cancer carries a not negligible risk of developing a second endometrial cancer. The second cancer may develop years after initial therapy and may have aggressive histologic and clinical features. This case underlines the importance for a long follow-up in women having received radio-chemotherapy alone.

96. Simultaneous medullary and renal cell carcinoma: Primary and secondary neoplasms in the thyroid

Author

Michela Campora, Paudice, M., Piol, N., Toncini, C., Vellone, V. G., Ansaldo, G. L., Varaldo, E., Fornarini, G., and Spina, B.

Subjects
Clear cell renal cell carcinoma, Thyroid, Thyroid gland, Medullary thyroid cancer, Clear cell renal cell carcinoma, Medullary thyroid cancer, Renal cancer cell, Renal cell carcinoma, Simultaneous lesions, Thyroid, Thyroid gland, Renal cancer cell, Renal cell carcinoma, Simultaneous lesions

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