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73 results on '"Vega, Gloria L."'

61. Interleukin-18, the Metabolic Syndrome, and Subclinical Atherosclerosis

Author

Zirlik, Andreas, primary, Abdullah, Shuaib M., additional, Gerdes, Norbert, additional, MacFarlane, Lindsey, additional, Schönbeck, Uwe, additional, Khera, Amit, additional, McGuire, Darren K., additional, Vega, Gloria L., additional, Grundy, Scott, additional, Libby, Peter, additional, and de Lemos, James A., additional

Published
2007
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66. Hepatic lipase

Author

Cohen, Jonathan C., primary, Vega, Gloria L., additional, and Grundy, Scott M., additional

Published
1999
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69. Effects of Crystalline Nicotinic Acid-Induced Hepatic Dysfunction on Serum Low-Density Lipoprotein Cholesterol and Lecithin Cholesteryl Acyl Transferase 11This work was supported in part by Grants HL-29252 and HL-22682 from the Department of Veterans Affairs; Grant MO-IRR00663 from the National Institutes of Health, Bethesda, Maryland; The Southwestern Medical Foundation; and the Moss Heart Foundation, Dallas, Texas.

Author

Tatò, Federico, primary, Vega, Gloria L, additional, and Grundy, Scott M, additional

Published
1998
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73. Adiponectin Strongly Correlates with Hepatic Triglyceride Lipase and Plasma Triglyceride Levels in African Americans.

Author

Clarenbach, Jacob J., Vega, Gloria L., Considine, Robert V., and Sumner, Anne E.

Subjects
*MUSCLE proteins, *TRIGLYCERIDES, *LIPASES, *AFRICAN Americans, *OBESITY, *INSULIN resistance
Abstract

African Americans often have normal high-density lipoprotein cholesterol (HDL-C) and low triglyceride levels despite insulin resistance and obesity. The higher than expected HDL-C levels are usually attributed to low levels of hepatic triglyceride lipase activity (HTGL). Factors that regulate HTGL in African Americans are not well delineated. In the current study, HTGL levels were examined in relation to body fat (body mass index (BMI) and waist circumference (WC)), insulin resistance indices (fasting plasma insulin and HOMA index) and adiponectin. Sixty-three African Americans (33 Men, 30 Women, median age 31 y, range 20-50 y, median BMI 28.6 kg/m², range 19.7-54.7 kg/m²) had anthropometry and measurement of post-heparin lipase activities (HTGL), plasma HDL-C, triglycerides and plasma adiponectin. HTGL correlated strongly with HDL-C (r =-0.52, P<0.0001) and adiponectin (r = -0.49, P<0.001). HTGL increased with BMI and WC (r =0.297, P=-0.018 and r =0.301, P=0.016, resp). Adiponectin correlated strongly with HDL-C (r =0.50, P<0.0001) and triglycerides (r = -0.493, P<0.001). Four multiple regression models predicted HTGL variability (P<0.001) in the study group: Model 1 with an adjusted R²=0.242 and a linear combination of adiponectin, BMI, and HOMA (log[sub e]); Model 2 (R²=0.229) with adiponectin + BMI + HOMA (log[sub e] + triglycerides (log[sub e]; Model 3 (R²=0.241) with adiponectin + age + BMI and Model 4 (R² =0.215) adiponectin + age + BMI + HOMA (logo + triglycerides (log[sub e]). It is apparent that about 23% of HTGL variability among African Americans can be explained by adiponectin levels in combination with markers of obesity and insulin resistance. In each model, the beta-coefficient for adiponectin with HTGL is in the range of 0.44 to 0.47 (P <0.002) rendering this parameter a major factor in HTGL variability. The data suggests that adiponectin is a strong determinant of HTGL levels and plasma triglyceride levels in African Americans. [ABSTRACT FROM AUTHOR]

Published
2007

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