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60. Channel-reach morphometric analysis on a headwater stream in a low-mountainous region: A case study from Mecsek Hills.

Author

VÍG, BALÁZS, VARGA, GÁBOR, BALOGH, RICHÁRD, LÓCZY, DÉNES, NAGYVÁRADI, LÁSZLÓ, and FÁBIÁN, SZABOLCS ÁKOS

Subjects
*COARSE woody debris, *FIELD research, *GEOGRAPHIC information systems, *GEOMORPHOLOGY
Abstract

Small catchments in mountainous regions affect downstream rivers as a primary source of sediment supply and also generate flash swasfloods, especially during extreme events. These floods have significantly shaped the catchments of small streams in the Mecsek Hills and some rural areas over the past two decades. However, there has been no previous study examining the hydromorphology of headwater catchments in low mountain environments in Hungary. The present study was meant to investigate the fundamental hydrogeomorphological properties of a first-order catchment. A customary and detailed GIS survey of 50-metre sections was aimed at deciphering flash flood vulnerability and geomorphic interrelations within a micro-watershed. We found moderate susceptibility to flash floods compared to the whole Mecsek Hills. Stable large woody debris jams were identified during the field survey as major geomorphic channel features functioning as natural barriers which drive channel evolution and reduce flood hazards. [ABSTRACT FROM AUTHOR]

Published
2023
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75. Structure-activity relationships of LDH catalysts for the glucose-to-fructose isomerisation in ethanol

Author

Karádi Krisztina Anna, Nguyen Tranh-Truc, Ádám Anna Adél, Baán Kornélia, Sápi András, Kukovecz Ákos, Kónya Zoltán, Sipos Pál Miklós, Pálinkó István, and Varga Gábor

Subjects
01.04. Kémiai tudományok
Abstract

Glucose-to-fructose isomerization is the key process in the reaction sequence that can lead to the total conversion of biomass into valuable fine chemicals. However, it is challenging to find an...

Published
2023

87. Saliva as a diagnostic specimen for detecting SARS-COV-2

Author

Czumbel, László, Varga, Gábor, Nagy, Ákos, Mandel, Iván, Hegyi, Anita, Kiss, Szabolcs, Lohinai, Zsolt, Steward, Martin, Szakács, Zsolt, and Hegyi, Péter

Subjects
SARS-CoV-2, Medicine and Health Sciences, COVID-19, Dental, Saliva, Diagnostics
Abstract

COVID-19 caused by SARS-CoV-2 is a serious and potentially deadly disease with an incidence rate of 36.1 per 100 000 population in the EU/EEA as of 25 March [Coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK – seventh update Rapid Risk Assessment, ECDC, 15.03.2020]. More than 80 000 new cases are reported worldwide each day [Situation update worldwide, as of 19 April 2020, ECDC, 19.04.2020]. Early diagnosis and isolation of the infected people will play an important role in stopping the further escalation of this pandemic. At the moment, application of nasopharyngeal swabs is the most common method for specimen collection. However, this method requires qualified personnel to collect the specimen, thus exposing the medical stuff to a higher risk of infection, and shortages of swabs are frequently reported. Due to these factors, the nasopharyngeal swab collection method is causing financial and logistic burden on healthcare systems. Additionally, nasopharyngeal specimen collection method causes serious discomfort to the patients. Besides, there are several contraindications, such as coagulopathy or anticoagulant therapy and significant nasal septum deviation. Clearly, there is a need for a simple, less invasive method that also reduces the risk to healthcare personnel. One candidate for specimen collection is saliva. Several scientific papers have been published on the possible use of saliva as a specimen for COVID-19 diagnosis. However, until now no systematic review or meta-analysis have been conducted to estimate the true potentials of saliva for COVID-19 diagnosis. Our aim is to conduct a systematic review and meta-analysis on the available relevant literature in order to estimate the reliability and consistency of saliva specimens for COVID-19 diagnostics.

Published
2022
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94. Clinical bracket failure rates between different bonding techniques: a systematic review and meta-analysis.

Author

Dudás, Csaba, Czumbel, László Márk, Kiss, Szabolcs, Gede, Noémi, Hegyi, Péter, Mártha, Krisztina, and Varga, Gábor

Subjects
FAILURE analysis, CONFIDENCE intervals, CLINICAL trials, CORRECTIVE orthodontics, TREATMENT failure
Abstract

Background Bracket failure increases the treatment time of orthodontic therapy and burdens patients with unnecessary costs, increased chair time, and possible new appointments. Objective To compare the bond failures of different orthodontic materials based on the results of available clinical studies. Search methods A systematic search of clinical trials was performed in the Cochrane, Embase, and Pubmed databases with no limitations. The list of investigated techniques contained conventional acid-etch primer (CM-AEP), self-etch primer (SEP), self-cure resin (SCR), and simple or resin-modified glass ionomer (RM-GIC) materials and procedures. Selection criteria Clinical studies reporting the failure rate of bonded brackets after using direct adhesive techniques on buccal sites of healthy teeth were included. Data collection and analysis Bracket failure rates from eligible studies were extracted by two authors independently. Risk ratios (RRs) were pooled using the random-effects model with DerSimonian–Laird estimation. Results Thirty-four publications, involving 1221 patients, were included. Our meta-analysis revealed no significant difference in the risk of bracket failures between SEP and CM-AEP. After 6, 12, and 18 months of bonding, the values of RR were 1.04 [95% confidence interval (CI), 0.67–1.61], 1.37 (95% CI, 0.98–1.92), and 0.93 (95% CI, 0.72–1.20), respectively. At 18 months, bracket failure was 4.9 and 5.2% for SEP and CM-AEP, respectively. Heterogeneity was good or moderate (I 2 < 42.2%). The results of RM-GIC at 12 months indicated a 57% lower risk of bracket failure using SCR as compared with RM-GIC (RR: 0.38; 95% CI, 0.24–0.61). At 18 months, bracket failures for SCR and RM-GIC were 15.8 and 36.6%, respectively (RR: 0.44; 95% CI, 0.37–0.52, I 2 = 78.9%), demonstrating three to six times higher failure rate than in the case of etching primer applications. Limitations A major limitation of the present work is that the included clinical trials, with no exceptions, showed variable levels of risk of bias. Another possible problem affecting the outcome is the difference between the clustering effects of the split mouth and the parallel group bracket allocation methods. Conclusions and implications The results revealed no significant difference between SEP and CM-AEP up to 18 months after application. RM-GIC had much worse failure rates than acid-etching methods; additionally, the superiority of SCR over RM-GIC was evident, indicating strong clinical relevance. Registration Prospero with CRD42020163362. [ABSTRACT FROM AUTHOR]

Published
2023
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97. Comprehensive Analysis of Key Proteins Involved in Radioresistance of Prostate Cancer by Integrating Protein-protein Interaction Networks

Author

Li Dujian, Németh Balázs, Gyöngyi Zoltán, Karádi Kázmér, Wang Xiaoxia, Memarpour Mahtab, Rasool Nouman, Hegyi Péter, Marta Katalin, Révész Péter, Tóth Barbara, Luan Yun, Taghvamanesh Sara, Tulchinsky Mark, Slonimsky Einat, Sang-Ngoen Thanyaporn, Qian Duocheng, Varga Gábor, Shao Jia, Liu Dongsen, Naseer Sheraz, M. Czumbel László, Shahbaz Umar, Li Quan, H. Morowvat Mohammad, Liu Xiaoli, Mátrai Péter, Sui Shujian, Gerber Gábor, Li Yinuo, Sun Yongchao, Gao Qi, Zhang Shanshan, Karami Forough, Su Hao, Zhu Yansong, Xu Chaoyue, Hussain Waqar, Karami Somayeh, Sadaeng Wuttapon, Szanyi István, Rafiee Azade, Zhang Zhaohua, and Daanial Khan Yaser

Subjects
Computational Mathematics, Prostate cancer, Radioresistance, Genetics, medicine, Key (cryptography), Computational biology, Biology, medicine.disease, Molecular Biology, Biochemistry, Protein protein interaction network
Abstract

Background: Radioresistance remains a significant obstacle in the treatment of prostate cancer (PCa). The mechanisms underlying the radioresistance in PCa remained to be further investigated. Methods: GSE53902 dataset was used in this study to identify radioresistance-related mRNAs. Protein-protein interaction (PPI) network was constructed based on STRING analysis. DAVID system was used to predict the potential roles of radioresistance-related mRNAs. Results: We screened and re-annotated the GSE53902 dataset to identify radioresistance-related mRNAs. A total of 445 up-regulated and 1036 down-regulated mRNAs were identified in radioresistance PCa cells. Three key PPI networks consisting of 81 proteins were further constructed in PCa. Bioinformatics analysis revealed that these genes were involved in regulating MAP kinase activity, response to hypoxia, regulation of the apoptotic process, mitotic nuclear division, and regulation of mRNA stability. Moreover, we observed that radioresistance-related mRNAs, such as PRC1, RAD54L, PIK3R3, ASB2, FBXO32, LPAR1, RNF14, and UBA7, were dysregulated and correlated to the survival time in PCa. Conclusion: We thought this study would be useful to understand the mechanisms underlying radioresistance of PCa and identify novel prognostic markers for PCa.

Published
2021

100. Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis

Author

Lantos, Krisztina, primary, Dömötör, Zsuzsa Réka, additional, Farkas, Nelli, additional, Kiss, Szabolcs, additional, Szakács, Zsolt, additional, Garami, András, additional, Varga, Gábor, additional, Lujber, László, additional, Kanaan, Reem, additional, Hegyi, Péter, additional, Fehér, Gergely, additional, and Gaál, Valéria, additional

Published
2022
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