846 results on '"Vanhaesebroeck, Bart"'
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52. Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development
53. Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy
54. Impact of PI3Kα (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis
55. Lessons for cancer drug treatment from tackling a non-cancerous overgrowth syndrome
56. Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency
57. METABRIC_TCGA_GSVA_PI3K_stemness_scores
58. Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
59. Molecules in medicine mini-review: isoforms of PI3K in biology and disease
60. Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype
61. Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover
62. Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity
63. Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion
64. Activity of any class IA PI3K isoform can sustain cell proliferation and survival
65. The PI3K p 110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1
66. The role of PI3Kα isoform in cardioprotection
67. The p110β Isoform of Phosphoinositide 3-Kinase Signals Downstream of G Protein-Coupled Receptors and Is Functionally Redundant with p110γ
68. Class IA Phosphoinositide 3-Kinases Are Obligate p85-p110 Heterodimers
69. Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma
70. HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
71. Precision Targeting of Mutant PI3Kα in Cancer by Selective Degradation
72. Ultrasensitive and Absolute Quantification of the Phosphoinositide 3-kinase/Akt Signal Transduction Pathway by Mass Spectrometry
73. Oncogenic Transformation Induced by the p110β, -γ, and -δ Isoforms of Class I Phosphoinositide 3-Kinase
74. Altered Macrophage Function Contributes to Colitis in Mice Defective in the Phosphoinositide-3 Kinase Subunit p110δ
75. SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target
76. CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway
77. PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart
78. Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
79. Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase
80. Lithium Chloride Potentiates Tumor Necrosis Factor-Mediated Cytotoxicity in vitro and in vivo
81. Long‐term p110α PI3K inactivation exerts a beneficial effect on metabolism
82. Characterisation of the transcriptional dynamics underpinning the function, fate, and migration of the mouse Anterior Visceral Endoderm
83. The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
84. Phosphoinositide 3-kinase [delta] regulates membrane fission of Golgi carriers for selective cytokine secretion
85. The PI3K p110[alpha] isoform regulates endothelial adherens junctions via Pyk2 and Rac1
86. The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice
87. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
88. Regulation of phosphoinositide 3-kinase expression in health and disease
89. Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenicPIK3CAmutant progenitors in the esophagus
90. Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif
91. NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells
92. Angiogenesis selectively requires the p110α isoform of P13K to control endothelial cell migration
93. The p110δ isoform of PI 3‐kinase negatively controls RhoA and PTEN
94. Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation
95. Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis.
96. Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
97. mTORC1 activity is supported by spatial association with focal adhesions
98. Signalling by PI3K isoforms: insights from gene-targeted mice
99. Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
100. Class III Phosphoinositide 3-Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling
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