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52. Plasma Procalcitonin Is an Independent Predictor of Graft Failure Late After Renal Transplantation

Author

van Ree, Rutger M., primary, de Vries, Aiko P. J., additional, Oterdoom, Leendert H., additional, Seelen, Marc A., additional, Gansevoort, Ron T., additional, Schouten, Jan P., additional, Struck, Joachim, additional, Navis, Gerjan, additional, Gans, Reinold O. B., additional, van der Heide, Jaap J. Homan, additional, van Son, Willem J., additional, and Bakker, Stephan J. L., additional

Published
2009
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53. Vascular Contraction and Preeclampsia

Author

Bakker, Winston W., primary, Henning, Rob H., additional, van Son, Willem J., additional, van Pampus, Maria G., additional, Aarnoudse, Jan G., additional, Niezen-Koning, Klary E., additional, Borghuis, Theo, additional, Jongman, Rianne M., additional, van Goor, Harry, additional, Poelstra, Klaas, additional, Navis, Gerjan, additional, and Faas, Marijke M., additional

Published
2009
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54. N-Terminal Pro-B-Type Natriuretic Peptide and Mortality in Renal Transplant Recipients Versus the General Population

Author

Oterdoom, Leendert H., primary, de Vries, Aiko P.J., additional, van Ree, Rutger M., additional, Gansevoort, Ron T., additional, van Son, Willem J., additional, van der Heide, Jaap J. Homan., additional, Navis, Gerjan, additional, de Jong, Paul E., additional, Gans, Reinold O.B., additional, and Bakker, Stephan J.L., additional

Published
2009
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55. Skin-Autofluorescence Is an Independent Predictor of Graft Loss in Renal Transplant Recipients

Author

Hartog, Jasper W. L., primary, Gross, Sascha, additional, Oterdoom, Leendert H., additional, van Ree, Rutger M., additional, de Vries, Aiko P. J., additional, Smit, Andries J., additional, Schouten, Jan P., additional, Nawroth, Peter P., additional, Gans, Reinold O. B., additional, van Son, Willem J., additional, Bierhaus, Angelika, additional, and Bakker, Stephan J. L., additional

Published
2009
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56. The Additional Detrimental Effects of Cold Preservation on Transplantation-Associated Injury in Kidneys from Living and Brain-Dead Donor Rats

Author

Hoeger, Simone, primary, Petrov, Kiril, additional, Reisenbuechler, Anke, additional, Fontana, Johann, additional, Selhorst, Jochen, additional, Hanusch, Christine, additional, Beck, Grietje, additional, Seelen, Marc A., additional, van Son, Willem J., additional, Waldherr, Ruediger, additional, Schnuelle, Peter, additional, and Yard, Benito A., additional

Published
2009
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60. Urinary Creatinine Excretion Reflecting Muscle Mass is a Predictor of Mortality and Graft Loss in Renal Transplant Recipients

Author

Oterdoom, Leendert H., primary, van Ree, Rutger M., additional, de Vries, Aiko P. J., additional, Gansevoort, Ron T., additional, Schouten, Jan P., additional, van Son, Willem J., additional, Homan van der Heide, Jaap J., additional, Navis, Gerjan, additional, de Jong, Paul E., additional, Gans, Reinold O. B., additional, and Bakker, Stephan J. L., additional

Published
2008
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65. Determinants of Insulin Resistance in Renal Transplant Recipients

Author

Oterdoom, Leendert H., primary, de Vries, Aiko P. J., additional, Gansevoort, Ron T., additional, van Son, Willem J., additional, van der Heide, Jaap J. Homan, additional, Ploeg, Rutger J., additional, de Jong, Paul E., additional, Gans, Reinold O. B., additional, and Bakker, Stephan J. L., additional

Published
2007
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67. Plasma Hemopexin Activity in Pregnancy and Preeclampsia

Author

Bakker, Winston W., primary, Donker, Rogier B., additional, Timmer, Albertus, additional, van Pampus, Mariëlle G., additional, van Son, Willem J., additional, Aarnoudse, Jan G., additional, van Goor, Harry, additional, Niezen-Koning, Klary E., additional, Navis, Gerjan, additional, Borghuis, Theo, additional, Jongman, Rianne M., additional, and Faas, Marijke M., additional

Published
2007
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84. Histochemical Detection of Ischemia-Like Alterations Induced in Kidney Tissue in vitro – Different Sensitivity to Oxidant Stress of Glomerular ENTPD1 versus E5NT.

Author

Vlaar, Alexander P. J., van Son, Willem J., and Bakker, Winston W.

Subjects
*ISCHEMIA, *IRRADIATION, *ENZYMES, *KIDNEY function tests, *KIDNEY glomerulus
Abstract

The expression of ENTPD1 (ecto-nucleoside triphosphate diphosphohydrolase) along the glomerular microvasculature of the kidney is downregulated in ischemic conditions, in contrast to E5NT (ecto-5′-nucleotidase), which may explain the increased tendency for intraglomerular microthrombus formation in vivo. It has been suggested that in ischemia, reactive oxygen species (ROS) affect glomerular ENTPD1, whereas E5NT seems less sensitive to oxidant stress. To test this hypothesis, a soluble ATP and ADP hydrolyzing enzyme solution (apyrase) [0.4 U/ml] or 5′-nucleotidase solution [0.33 U/ml] as well renal tissue were exposed to ROS, generated by γ-irradiation in vitro. The enzymes diluted in distilled water or cryostat rat kidney sections were exposed to γ-irradiation (0.037 Gy/s) for 0, 2, 5, 10, or 15 min, with or without supplementation of the ROS scavenger dimethylsulfoxide (DMSO). The enzyme activity of the samples was biochemically tested using standard methods, before and after irradiation. The reaction product of irradiated versus nonirradiated kidney sections was semiquantitatively evaluated after histochemical staining for either glomerular ENTPD1 or glomerular E5NT expression. The results show that the enzyme activity in samples of soluble apyrase was significantly decreased after irradiation. This effect was inhibited by DMSO. In contrast, 5′-nucleotidase activity showed only a limited decline of the activity curve after irradiation, which could also be restored following supplementation of DMSO. Glomerular ENTPD1 expression showed significant decrease after irradiation of kidney sections; again, this was inhibitable by DMSO. Glomerular E5NT activity was not altered by irradiation and DMSO supplementation did not affect its activity. It is concluded that soluble apyrase as well as the glomerular ENTPD1 are sensitive to oxidant stress, which may explain their downregulation in the ischemic condition in vivo. However, soluble 5′-nucleotidase and E5NT seem much less sensitive to ROS. This relative insensitivity of E5NT to oxidant injury may counteract ischemic injury by promoting local generation of adenosine in the ischemic micro-environment. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2009
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91. Overcoming the Problem of Cytomegalovirus Infection after Organ Transplantation: Calling for Heracles?

Author

van Son, Willem J., de Maar, Eltjo F., van der Bij, Wim, van den Berg, Arie P., Verschuuren, Erik A.M., and The, T. Hauw

Abstract

Although diagnosis of CMV infections and treatment of CMV disease with effetive antiviral drugs have become much easier, the persistent problem of CMV infection after solid-organ transplantation still requires solid knowledge of the pathophysiology of its clinical manifestations in order to minimize the impact of CMV infections in the future. The complex symptomatology of CMV infection after solid-organ transplantation is reviewed as well as some of the new theories attempting to explain the myriad of symptoms seen after transplantation.

Published
2000
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92. Towards Standardization of the Human Cytomegalovirus Antigenemia Assay

Author

Verschuuren, Erik A.M., Harmsen, Martin C., Limburg, Pieter C., van der Bij, Wim, van den Berg, Arie P., Kas-Deelen, Adri ana M., Meedendorp, Boelo, van Son, Willem J., and The, T. Hauw

Abstract

The Human Cytomegalovirus antigenemia (HCMV-Agemia) test has been accepted worldwide as a clinical tool in the diagnosis and management of HCMV-associated syndromes in immunocompromised patients. The many modifications proposed since the first description by our laboratory make standardisation of the HCMV-Agemia assay necessary to enable multicenter clinical trials. We report the initial work for standardization of the HCMV-Agemia assay. A standard protocol is proposed, the optimal distribution conditions are investigated and the results of the shipment of positive and negative test slides as well as of two sets of coded internal standard slides are discussed. The main conclusions are that standard slides can be distributed at room temperature and that the results of participating laboratories with the coded internal standard slides were strikingly similar in spite of differences in HCMV-Agemia protocols used by participating laboratories.

Published
2000
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97. High human cytomegalovirus DNAemia early post-transplantation associates with irreversible and progressive loss of renal function - a retrospective study.

Author

Lollinga WT, Rurenga-Gard L, van Doesum W, van Bergen R, Diepstra A, Vonk JM, Riezebos-Brilman A, Niesters HGM, van Son WJ, van den Born J, and Sanders JS

Subjects
Adult, Cytomegalovirus Infections blood, Cytomegalovirus Infections virology, Female, Glomerular Filtration Rate, Humans, Kidney physiopathology, Male, Middle Aged, Retrospective Studies, Time Factors, Viral Load, Viremia blood, Viremia etiology, Viremia virology, Cytomegalovirus genetics, Cytomegalovirus Infections etiology, DNA, Viral blood, DNA, Viral genetics, Kidney Transplantation adverse effects
Abstract

Transplant recipients are prone to viral infections, which could affect renal transplantation outcome. Our aim was to assess the effects of early human cytomegalovirus (CMV) DNAemia on transplant renal function. A total of 264 (age 50.9 ± 13.5; male 55%) renal transplantation recipients undergoing preemptive anti-CMV therapy were retrospectively categorized based on early (<3 months post-Tx) CMV peak viral load (PVL); PVL ≤ 536, PVL536-6310, or PVL > 6310 International Units/ml (IU/ml). Estimated glomerular filtration rate (eGFR) was analyzed between 1 and 36 months post-transplantation with Kruskal-Wallis test, linear regression, and a linear mixed-effects model. CMV infection was detectable in 113 (43%) recipients within 49 [38-67] days. Subjects with PVL > 6310 had statistically significant ~5-13 ml/min lower eGFR between 3 and 36 months compared to PVL ≤ 536 and PVL536-6310. eGFR declined from 46.1 to 40.7 ml/min/1.73 m 2 (-12%) over 3 years, and the annual decrease for pronounced infection with high PVL was 2.0 ml/min/1.73 m 2 faster than for noninfected or mildly infected subjects. In conclusion, high CMV DNAemia early after renal transplantation was associated with significant loss of renal function, from which subjects did not recover. The severity of infection (high PVL early post-transplantation), more than the infection per se, was related to irreversible and progressive loss of renal function., (© 2017 Steunstichting ESOT.)

Published
2017
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98. Body mass index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients.

Author

Gross S, Homan van der Heide JJ, van Son WJ, Gans RO, Foell D, Navis G, and Bakker SJ

Subjects
Biomarkers blood, Cell Death, Female, Humans, Linear Models, Male, Middle Aged, S100 Calcium Binding Protein beta Subunit, Body Mass Index, Creatinine blood, Kidney Transplantation, Nerve Growth Factors blood, S100 Proteins blood
Abstract

Background: S100B is a prominent cell damage marker which can lead to sustained pro-inflammatory signaling. The aim was to investigate cross-sectional associations of steady-state S100B concentrations, particularly with C-reactive protein (CRP), in renal transplant recipients (RTRs) and also to investigate prospectively whether S100B would predict graft failure or mortality., Material/methods: Outpatient RTRs with a graft functioning for >1 year were eligible for participation in this study. S100B was determined at baseline from serum. Mortality and the occurrence of graft failure were recorded until September 2007. Multivariable linear regression analyses were performed to identify potential determinants of S100B. Multivariable Cox regression analyses were performed to investigate S100B as a potential predictor of mortality or graft failure., Results: Five hundred eighty-one RTRs participated in the study. The median S100B concentration was 0.19 (0.14-0.25) microg/l. Recipient age (beta=0.009, p=0.02), body mass index (BMI) (beta=0.021, p<0.001), and creatinine clearance (beta=-015, p<0.001) were independently associated with S100B. During follow-up, 95 RTRs (16.4%) died and 41 (7.1%) developed graft failure. S100B levels did not predict mortality or graft failure., Conclusions: BMI, creatinine clearance, and age are determinants of steady-state serum S100B concentrations in renal transplant recipients. The association of BMI with S100B suggests that S100B might be a new adipokine.

Published
2010

99. Possible contribution of cytomegalovirus infection to the high risk of (recurrent) venous thrombosis after renal transplantation.

Author

Lijfering WM, de Vries AP, Veeger NJ, van Son WJ, Bakker SJ, and van der Meer J

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Recurrence, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Venous Thrombosis epidemiology, Venous Thrombosis virology, Cytomegalovirus Infections complications, Kidney Transplantation adverse effects, Venous Thrombosis etiology
Abstract

Renal transplant recipients are at an increased risk of venous thrombosis, which has been regarded as a postoperative complication, although it may persist afterwards. As numerous case reports have shown that active cytomegalovirus (CMV) infection can be found at time of onset of venous thrombosis, and is frequently found in renal transplant recipients, we hypothesized that one might be the result of the other. To calculate the risk of (recurrent) venous thrombosis in renal transplant recipients, and to see whether CMV infection influenced this risk, we retrospectively analysed 606 living consecutive renal transplant recipients. CMV status at time of transplantation and at time of enrolment was determined. Absolute risks of first venous thrombosis and recurrence were compared with CMV status, and were corrected for surgery related venous thrombosis, age, and anticoagulant treatment. Annual incidence of venous thrombosis was 0.88% (95% CI, 0.65-1.15) in all recipients and 0.59% (95% CI, 0.41-0.83) corrected for surgery related venous thrombosis. CMV positive and seroconverted recipients tended to have an increased risk of venous thrombosis compared to CMV negative recipients; corrected relative risks were 2.0 (95% CI, 0.9-5.2) and 1.7 (95% CI, 0.6-4.7), respectively. The cumulative 10-year recurrence rate of venous thrombosis in CMV seronegative, seroconverted, and seropositive recipients was 10%, 51% and 59%, respectively. We conclude that CMV infection tended to be associated with an increased risk of (recurrent) venous thrombosis. Prospective studies are warranted to establish this observation, which suggests that CMV infection influences the high risk of (recurrent) venous thrombosis in renal transplant recipients.

Published
2008
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