30,426 results on '"Tyrrell BE"'
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52. Inauguration of the Anthropological Society of Bombay, 1886
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Leith, Edward Tyrrell, primary
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- 2024
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53. Finite Undecidability in Fields II: PAC, PRC and PpC Fields
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Tyrrell, Brian
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Mathematics - Logic - Abstract
A field $K$ in a ring language $\mathcal{L}$ is finitely undecidable if $\mbox{Cons}(\Sigma)$ is undecidable for every nonempty finite $\Sigma \subseteq \mbox{Th}(K; \mathcal{L})$. We adapt arguments originating with Cherlin-van den Dries-Macintyre/Ershov (for PAC fields) and Haran (for PRC fields) to prove all PAC and PRC fields are finitely undecidable. We describe the difficulties that arise in adapting the proof to P$p$C fields, and show no bounded P$p$C field is finitely axiomatisable. This work is drawn from the author's PhD thesis and is a sequel to arXiv:2210.12729., Comment: 26 pages. Update expands on undecidability machinery, removes PpC finite undecidability, and fixes typos etc
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- 2022
54. TWrist: An agile compliant 3-DoF tensegrity joint
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Tianyuan Wang, Mark A. Post, and Andy M. Tyrrell
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Tensegrity ,Soft robot ,Tensegrity control ,Robot manipulator ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Tensegrity structures, with their unique physical characteristics, hold substantial potential in the field of robotics. However, the very structures that will give tensegrity robots potential advantages over traditional robots also hold long term challenges. Due to the inherent high redundancy of tensegrity structures and the employment of tension elements, tensegrity robots exhibit excellent stability, compliance, and flexibility, although this also results in lower structural deformation efficiency. Existing research has endeavoured to enhance the motion performance of tensegrity robots, exploring diverse approaches such as actuation schemes, structure design, aligned with control algorithms. However, the physical constraints of the elements in such structures and the absence of suitable controllers impede further advancements in the usefulness of tensegrity robots. This paper presents a novel design based on an under constrained transition region design and a tailored control approach based on inverse kinematics, improving the motion performance of the proposed novel tensegrity joint. Through this approach, the tensegrity joint, while preserving the advantages of compliance and flexibility expected from tensegrity structures, offers three degrees of rotational freedom, mirroring the controllability of conventional rigid-body joints. The results demonstrate the capability of tensegrity-based robotic joints to provide flexible actuation under situations demanding high compliance. The integration of structure design with a tailored control approach offers a pioneering model for future development of tensegrity robots, underscoring the practical viability of tensegrity structures in the realm of robotics.
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- 2024
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55. Evolving Design For Engineering Structures.
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Rahul Dubey, Simon J. Hickinbotham, Edgar Buchanan, Andrew Colligan, Imelda Friel, Mark Price, and Andy M. Tyrrell
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- 2024
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56. A Quality Diversity Study in EvoDevo Processes for Engineering Design.
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Edgar Buchanan, Simon J. Hickinbotham, Rahul Dubey, Imelda Friel, Andrew Colligan, Mark Price, and Andy M. Tyrrell
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- 2024
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57. Enough is Enough: Learning to Stop in Generative Systems.
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Colin Roitt, Simon J. Hickinbotham, and Andy M. Tyrrell
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- 2024
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58. Enough is Enough: Learning to Stop in Generative Systems
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Roitt, Colin, Hickinbotham, Simon, Tyrrell, Andy M., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Johnson, Colin, editor, Rebelo, Sérgio M., editor, and Santos, Iria, editor
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- 2024
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59. The unfinished business of integrity
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Pender, Kieran and Tyrrell, Jade
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- 2024
60. Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor–Induced Hypophysitis
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Quandt, Zoe, Kim, Stephanie, Villanueva-Meyer, Javier, Coupe, Catherine, Young, Arabella, Kang, Jee Hye, Yazdany, Jinoos, Schmajuk, Gabriela, Rush, Stephanie, Ziv, Elad, Perdigoto, Ana Luisa, Herold, Kevan, Lechner, Melissa G, Su, Maureen A, Tyrrell, J Blake, Bluestone, Jeffrey, Anderson, Mark, and Masharani, Umesh
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Biomedical and Clinical Sciences ,Clinical Sciences ,Immunology ,Clinical Research ,Biomedical Imaging ,2.1 Biological and endogenous factors ,Aetiology ,hypophysitis ,immune checkpoint inhibitors ,immunotherapy ,immune-related adverse events ,pan-hypopituitarism ,adrenal insufficiency ,Cardiovascular medicine and haematology - Abstract
ContextHypophysitis is a known immune-related adverse event (irAE) of immune checkpoint inhibitors (CPIs), commonly associated with CTLA-4 inhibitors and less often with PD-1/PD-L1 inhibitors.ObjectiveWe aimed to determine clinical, imaging, and HLA characteristics of CPI-induced hypophysitis (CPI-hypophysitis).MethodsWe examined the clinical and biochemical characteristics, magnetic resonance imaging (MRI) of the pituitary, and association with HLA type in patients with CPI-hypophysitis.ResultsForty-nine patients were identified. Mean age was 61.3 years, 61.2% were men, 81.6% were Caucasian, 38.8% had melanoma, and 44.5% received PD-1/PD-L1 inhibitor monotherapy while the remainder received CTLA-4 inhibitor monotherapy or CTLA-4/PD-1 inhibitor combination therapy. A comparison of CTLA-4 inhibitor exposure vs PD-1/PD-L1 inhibitor monotherapy revealed faster time to CPI-hypophysitis (median 84 vs 185 days, P < .01) and abnormal pituitary appearance on MRI (odds ratio 7.00, P = .03). We observed effect modification by sex in the association between CPI type and time to CPI-hypophysitis. In particular, anti-CTLA-4 exposed men had a shorter time to onset than women. MRI changes of the pituitary were most common at the time of hypophysitis diagnosis (55.6% enlarged, 37.0% normal, 7.4% empty or partially empty) but persisted in follow-up (23.8% enlarged, 57.1% normal, 19.1% empty or partially empty). HLA typing was done on 55 subjects; HLA type DQ0602 was over-represented in CPI-hypophysitis relative to the Caucasian American population (39.4% vs 21.5%, P = 0.01) and CPI population.ConclusionThe association of CPI-hypophysitis with HLA DQ0602 suggests a genetic risk for its development. The clinical phenotype of hypophysitis appears heterogenous, with differences in timing of onset, changes in thyroid function tests, MRI changes, and possibly sex related to CPI type. These factors may play an important role in our mechanistic understanding of CPI-hypophysitis.
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- 2023
61. Finite Undecidability in Fields I: NIP Fields
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Tyrrell, Brian
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Mathematics - Logic - Abstract
A field $K$ in a ring language $\mathcal{L}$ is finitely undecidable if $\mbox{Cons}(\Sigma)$ is undecidable for every nonempty finite $\Sigma \subseteq \mbox{Th}(K; \mathcal{L})$. We extend a construction of Ziegler and (among other results) use a first-order classification of Anscombe and Jahnke to prove every NIP henselian nontrivially valued field is finitely undecidable. We conclude (assuming the NIP Fields Conjecture) that every NIP field is finitely undecidable. This work is drawn from the author's PhD thesis., Comment: 21 pages. Extended results to all mixed characteristic henselian valued fields via a new method. Added further applications and examples
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- 2022
62. New Lower Bounds for Cap Sets
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Tyrrell, Fred
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Mathematics - Combinatorics ,Computer Science - Discrete Mathematics ,Mathematics - Number Theory ,11B25, 11B30, 11B75 - Abstract
A cap set is a subset of $\mathbb{F}_3^n$ with no solutions to $x+y+z=0$ other than when $x=y=z$. In this paper, we provide a new lower bound on the size of a maximal cap set. Building on a construction of Edel, we use improved computational methods and new theoretical ideas to show that, for large enough $n$, there is always a cap set in $\mathbb{F}_3^n$ of size at least $2.218^n$., Comment: Discrete Analysis journal version, 18 pages
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- 2022
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63. Generalizations of the proximal method of multipliers in convex optimization
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Rockafellar, R. Tyrrell
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- 2024
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64. Stemless anatomic total shoulder arthroplasty is associated with less early postoperative pain
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Brian C. Werner, MD, M. Tyrrell Burrus, MD, Patrick J. Denard, MD, Anthony A. Romeo, MD, Evan Lederman, MD, Justin W. Griffin, MD, Benjamin Sears, MD, Anup Shah, Asheesh Bedi, Benjamin Sears, Bradford Parsons, Brandon Erickson, Brian C. Werner, Bruce Miller, Christopher O'Grady, Daniel Davis, David Lutton, Evan Lederman, Joern Steinbeck, John Tokish, Julia Lee, Kevin Farmer, Mariano Menendez, Matthew Provencher, Michael Bercik, Michael Kissenberth, Patric Raiss, Patrick J. Denard, Peter Habermeyer, Philipp Moroder, Russell Huffman, Samuel Harmsen, Timothy Lenters, Tyrrell Burrus, Tyler Brolin, Anthony Romeo, R. Alexander Creighton, and Justin W. Griffin
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Shoulder arthroplasty ,Stemless ,Pain ,Anatomic shoulder replacement ,Sleep ,VAS ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background: Improvements in pain control after shoulder arthroplasty with a reduction in narcotic use continues to be an important postoperative goal. With the increased utilization of stemless anatomic total shoulder arthroplasty (aTSA), it is relevant to compare between stemmed and stemless arthroplasty to assess if there is any association between this implant design change and early postoperative pain. Methods: Patients from a multicenter, prospectively-maintained database who had undergone a stemless aTSA with a minimum of two year clinical follow-up were retrospectively identified. Patients who underwent aTSA with a short stem were identified in the same registry, and matched to the stemless aTSA patients by age, sex and preoperative pain score. The primary study outcome was the Visual Analog Scale pain score. Secondary pain outcomes were the American Shoulder and Elbow Surgeons shoulder pain subscore, Western Ontario Osteoarthritis of the Shoulder physical symptoms subscore, and the Single Assessment Numeric Evaluation score. Finally, the percentage of patients who could sleep on the affected shoulder was assessed for each group. These pain-related clinical outcomes were assessed and compared preoperatively, and postoperatively at 9 weeks, 26 weeks, one year and two years. For all statistical comparisons, P > .05 was considered significant. Results: 124 patients were included in the study; 62 in each group. At 9 weeks after surgery, statistically significantly improved pain control was reported by patients undergoing stemless aTSA, as assessed by the Visual Analog Scale (stemless: 1.5, stemmed: 2.5, P = .001), American Shoulder and Elbow Surgeons pain subscore (stemless: 42.4, stemmed: 37.3, P
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- 2024
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65. Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice
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Tyrrell, Daniel J., Wragg, Kathleen M., Chen, Judy, Wang, Hui, Song, Jianrui, Blin, Muriel G., Bolding, Chase, Vardaman, III, Donald, Giles, Kara, Tidwell, Harrison, Ali, Md Akkas, Janappareddi, Abhinav, Wood, Sherri C., and Goldstein, Daniel R.
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- 2023
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66. Preface to Asen L. Dontchev Memorial Special Issue
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Hager, William W., Rockafellar, R. Tyrrell, and Veliov, Vladimir M.
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- 2023
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67. Generic linear convergence through metric subregularity in a variable-metric extension of the proximal point algorithm
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Rockafellar, R. Tyrrell
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- 2023
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68. Automated screening of computed tomography using weakly supervised anomaly detection
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Hibi, Atsuhiro, Cusimano, Michael D., Bilbily, Alexander, Krishnan, Rahul G., and Tyrrell, Pascal N.
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- 2023
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69. Undecidability in some field theories
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Tyrrell, Brian, Koenigsmann, Jochen, and Zilber, Boris
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Undecidability ,Algebraic number theory ,Model Theory - Abstract
This thesis is a study of undecidability in some field theories. Specifically, we are interested in geometrically oriented problems and have focused our attention in two directions along these lines. The first direction bases on determining the decidability of certain sets of first-order sentences over positive characteristic function fields. We will draw parallel to the problem of algorithmically determining in some cases the existence of points on varieties in positive characteristic function fields; equivalently the existence of certain maps between varieties over other positive characteristic fields. The second direction bases on determining the decidability of first-order consequences of nonempty finite collections of L_r-sentences, true in fields with plenty of geometric structure. This is connected to the former direction by the fact that a decidable field has a recursive axiomatisation - what if we study a (nonempty) finite subset of the axiomatisation? Undecidability results. Motivated by classification-theoretic conjectures, we will examine 'wilder' classes of fields in turn and generalise a result of Ziegler to NIP henselian nontrivially valued fields (and beyond). We move to PAC & PRC fields and prove they are finitely undecidable, resolving two open questions of Shlapentokh & Videla, and describe the difficulties that arise in adapting the proof to PpC fields. We pose the question: 'is every infinite field finitely undecidable'?
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- 2023
70. Macroeconomics & inequality
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Tyrrell-Hendry, Lee, Snell, Andrew, and Thomas, Jonathan
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Macroeconomics ,inequality ,Wealth Distribution ,social welfare-maximising policy ,Global Imbalances - Abstract
This thesis explores inequality and its effects on the macroeconomy. Each chapter is concerned with heterogeneity between households or firms in some dimension: the first simply explores whether a standard model can capture the degree of inequality observed in the data; the second and third tackle the implications of such inequality for some aspect of policy. In all three papers I adopt the approach now common in the literature of viewing inequality as arising from idiosyncratic shocks and incomplete markets. In this lay summary I briefly discuss each chapter. MATCHING THE WEALTH DISTRIBUTION WITH INCOME INEQUALITY & RISK: I show that a standard incomplete markets model with labour income risk alone, when modelled accurately using a new method, can broadly match the distribution of wealth observed in the US and UK, whereas adding capital income risk does little to concentrate wealth further; both findings are in contrast to the prior literature. Moreover, I show that increased labour income inequality and risk can account for around a third of the rise in the concentration of wealth among the top 1% in the US since the 1970s, and about 0.5pp of the decline in real interest rates. SHOULD I STAY (IN SCHOOL) OR SHOULD I GO (TO WORK): How should governments calibrate the desire for redistribution via progressive taxation against the need to incentivise the accumulation of human capital through schooling? I explore this question in a heterogeneous agent model featuring stochastic human capital accumulation, endogeneous labour supply and an education choice modelled as a stopping time problem, where agents choose an optimal number of years to study before starting work. The latter feature addresses a shortcoming of much of the literature that typically models education decisions as a time allocation problem - which overstates the ability of older workers to insure themselves against obsolesence of their human capital and hence understates the welfare benefits of public insurance, for example through progressive taxation - or as a stylised problem with no resource or opportunity costs, which understates the bite of financial frictions, and hence the potential welfare gains from subsidising higher education. The social welfare-maximising policy features generous subsidies for education and highly progressive labour taxes. This result is robust to myriad extensions, including weakening the extent of financial frictions by allowing students to borrow. EM FOREVER BLOWING BUBBLES: GLOBAL IMBALANCES & THE LIMITS OF FISCAL SPACE: What are the limits on how much a government can borrow when the real interest rate on public debt is below the growth rate of the economy? I explore this question in a framework where household entrepreneurs make risky investments under incomplete markets. Such risks induce them to engage in precautionary saving, which lowers equilibrium interest rates and hence expands the fiscal space available to governments. I expand on the prior literature by introducing emerging market (EM) economies - where entrepreneurs face even greater risk and hence engage in more aggressive precautionary saving - as well as limits to the private supply of safe assets. Both elements reduce equilibrium real interest rates in the developed world and further inflate the bubble in public debt, affording developed market (DM) governments even greater fiscal space. I quantify the extent of fiscal space available to governments: how much debt they can issue without having to run surpluses, or how large a deficit they can sustainably run. But I also show that such borrowing carries risks, and governments must design fiscal rules to ensure their debt is both stable in the short run and sustainable in the long run, and that moreover that such policies are in general not Pareto-improving.
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- 2023
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71. Patterns and trends of medicinal poisoning substances: a population-based cohort study of injuries in 0–11 year old children from 1998–2018
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Edward G Tyrrell, Elizabeth Orton, Laila J Tata, and Denise Kendrick
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Injury ,Accident ,Child safety ,Child public health ,Epidemiology ,Social deprivation ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background There have been sharp increases in antidepressant and opioid prescriptions over the last 10 years, as well as increased over-the-counter medicine availability. However, the impact on childhood medicinal poisonings rates, particularly by socioeconomic deprivation is unclear. This study reports population level medicinal poisoning substance patterns in England among children aged 0–11 years, helping inform safety advice and poisoning prevention interventions. Methods An open cohort study of 1,489,620 0–11 year olds was conducted from 1998 to 2018, using the Clinical Practice Research Datalink, to examine inpatient hospital admissions for poisoning. Incidence rates and adjusted incidence rate ratios (aIRR) were calculated for poisoning substance groups by age, sex, socio-economic deprivation and year. Results 3,685 medicinal poisoning hospital admissions were identified. The most common substances were paracetamol (33.2%), dependence/withdrawal risk drugs (DWRD - antidepressants, opioids, gabapentinoids, benzodiazepines) (13.5%) and other over-the-counter (OTC) analgesics/anti-common cold drugs (13.0%). Over the study period DWRD poisonings decreased 33% (aIRR 0.67, 95%CI 0.50–0.90 comparing 2013/14-2017/18 to 1998/99-2002/03), while paracetamol poisonings increased 43% (aIRR 1.43, 95%CI 1.20–1.70 for the same periods), with no change in incidence rates for other OTC drugs (aIRR 0.82, 95% CI 0.60–1.12) or all medications combined (aIRR 0.97, 95%CI 0.88–1.07). A gradient in poisonings by area-level socioeconomic deprivation was shown for all medications (aIRR 1.32, 95%CI 1.18–1.47 for most deprived compared to least deprived quintile), and DWRDs (aIRR 2.03, 95%CI 1.42–2.88 for 4th most deprived quintile and aIRR 1.88, 95%CI 1.32–2.66 for 5th most deprived quintile, compared to least deprived quintile), but not for paracetamol or other OTC drug poisonings. Conclusions Poisonings from DWRDs decreased by 33%, while paracetamol poisonings increased by 43% during the study period. There was a gradient by area-level socioeconomic deprivation in prescribed medication poisonings, including drugs with withdrawal/dependence risk, but not OTC medication poisonings. Households in more socioeconomically deprived areas have the potential to benefit most from measures to improve safe storage of medicines and are likely to require targeted interventions providing education and safety equipment. In addition, universal promotion of the safe storage of OTC and prescribed medicines must be provided by prescribers, community pharmacies and other outlets of such medication.
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- 2024
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72. Three years of weekly DEMs, aerial orthomosaics and surveyed shoreline positions at Waikīkī Beach, Hawai‘i
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Anna B. Mikkelsen, Kristian K. McDonald, Julianne Kalksma, Zachary H. Tyrrell, and Charles H. Fletcher
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Science - Abstract
Abstract In this dataset, we present 128 coastal surveys conducted between 2018 and 2021 at Kahaloa Beach, also known as the Royal Hawaiian Beach, in Waikīkī, Hawai‘i. Surveys were conducted on a near-weekly basis, providing a 0.5 m digital elevation model, an orthorectified image mosaic with 0.03 m resolution, and shoreline vectors at MHHW and MSL, along with a surveyed shoreline position for each survey. We captured overlapping images using a small Unoccupied Aerial System (sUAS), processing the imagery with photogrammetric software to produce orthomosaics and Digital Terrain Models (DTM). Simultaneously, the shoreline position and reference points for sUAS-derived products were surveyed using total station and rod-mounted surveying prism. A quality assessment of 424 randomly sampled points across two surveys showed normally distributed errors of DTM elevations (µ1 = 0.0060 m; σ 1 = 0.0998 m; µ2 = 0.0035 m; σ 2 = 0.0680). Elevation uncertainties were quantified as 95% confidence intervals (±0.0130 m and ±0.0095 m). These data are intended to encourage research on reef-fringed beaches and provide a dataset for evaluating the accuracy of satellite-derived shorelines at reef-fringed beaches.
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- 2024
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73. Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis
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Pavel Loginovic, Feiyi Wang, Jiang Li, Lauric Ferrat, Uyenlinh L. Mirshahi, H. Shanker Rao, Axel Petzold, Jessica Tyrrell, Harry D. Green, Michael N. Weedon, Andrea Ganna, Tiinamaija Tuomi, David J. Carey, UKBB Eye & Vision Consortium, FinnGen, Geisinger-Regeneron DiscovEHR Collaboration, Richard A. Oram, and Tasanee Braithwaite
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Science - Abstract
Abstract Optic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GRS) with demographic risk factors (age, sex) significantly improved MS prediction in undifferentiated ON; one standard deviation of MS-GRS increased the Hazard of MS 1.3-fold (95% confidence interval 1.07–1.55, P
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- 2024
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74. Photon-Counting Technologies for Efficient High-Capacity Space-to-Ground Laser Communications§.
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David O. Caplan, Zachary J. Darling, Matthew Edward Grein, Matt Guyton, David Russo, Brian Tyrrell, and Andrew Wagner
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- 2024
75. Enough is Enough: Learning to Stop in Generative Systems
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Roitt, Colin, primary, Hickinbotham, Simon, additional, and Tyrrell, Andy M., additional
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- 2024
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76. Stemless anatomic total shoulder arthroplasty is associated with less early postoperative pain
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Shah, Anup, Bedi, Asheesh, Sears, Benjamin, Parsons, Bradford, Erickson, Brandon, Werner, Brian C., Miller, Bruce, O'Grady, Christopher, Davis, Daniel, Lutton, David, Lederman, Evan, Steinbeck, Joern, Tokish, John, Lee, Julia, Farmer, Kevin, Menendez, Mariano, Provencher, Matthew, Bercik, Michael, Kissenberth, Michael, Raiss, Patric, Denard, Patrick J., Habermeyer, Peter, Moroder, Philipp, Huffman, Russell, Harmsen, Samuel, Lenters, Timothy, Burrus, Tyrrell, Brolin, Tyler, Romeo, Anthony, Creighton, R. Alexander, Griffin, Justin W., Burrus, M. Tyrrell, and Romeo, Anthony A.
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- 2024
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77. Bridging the conservation and development trade‐off? A working landscape critique of a conservancy in the Maasai Mara
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Peter Tyrrell, Lauren Evans, Peadar Brehony, Philippa Wood, Rebekah Karimi, Dickson oleKaelo, Freddie Hunter, Rose Muiyuro, Esther Kang'ethe, and Brian Perry
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conservancy ,conservation ,Maasai Mara ,pastoralism ,working‐landscape ,Environmental sciences ,GE1-350 ,Ecology ,QH540-549.5 - Abstract
Abstract The recent call to halt biodiversity loss by protecting half the planet has been hotly contested because of the extent to which people might be excluded from these landscapes. It is clear that incorporating landscapes that implicitly work for indigenous people is vital to achieving any sustainable targets. We examine an attempt to balance the trade‐offs between conservation and development in Enonkishu Conservancy in the Maasai Mara, using a working landscape approach. Mobile livestock production strategies are theoretically consistent with wildlife‐based activities and can present a win‐win solution for both conservation and development. We explore the success and failings of Enonkishu's evolving attempts to achieve this: addressing the criticism of the conservation sector that it fails to learn from its mistakes. We found that Enonkishu has had considerable positive conservation outcomes, preventing the continued encroachment of farmland and maintaining and improving rangeland health relative to the surrounding area, while maintaining diverse and large populations of wildlife and livestock. The learning from certain ventures that failed, particularly on livestock, has created institutions and governance that, while still evolving, are more robust and relevant for conservancy members, by being fluid and inclusive. Practical implication: Diverse revenue streams (beyond tourism, including a residential estate, livestock venture and philanthropy) enabled Enonkishu to withstand the pressures of COVID‐19. Livestock is crucial for defining the vision of the conservancy, and the institutions and governance that underpin it.
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- 2024
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78. Using diffusion models to generate synthetic labeled data for medical image segmentation.
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Daniel G. Saragih, Atsuhiro Hibi, and Pascal N. Tyrrell
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- 2024
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79. Generalizations of the proximal method of multipliers in convex optimization.
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R. Tyrrell Rockafellar
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- 2024
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80. International circumpolar surveillance: update on the interlaboratory quality control program for Streptococcus pneumoniae, 2009 to 2020
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Alyssa R. Golden, Averil Griffith, Brenna C. Simons, Alisa Reasonover, Hans-Christian Slotved, Brigitte Lefebvre, Karl G. Kristinsson, Donna Hurteau, Gregory J. Tyrrell, Michael G. Bruce, and Irene Martin
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Streptococcus pneumoniae ,quality control ,serotyping ,antimicrobial susceptibility ,circumpolar surveillance ,invasive bacterial disease ,Microbiology ,QR1-502 - Abstract
ABSTRACT The International Circumpolar Surveillance (ICS) program is a population-based surveillance network for invasive bacterial diseases throughout Arctic countries and territories. The ICS quality control program for Streptococcus pneumoniae serotyping and antimicrobial susceptibility testing has been ongoing since 1999. Current participating laboratories include the Provincial Laboratory for Public Health in Edmonton, Alberta; Laboratoire de santé publique du Québec in Sainte-Anne-de-Bellevue, Québec; the Centers for Disease Control’s Arctic Investigations Program in Anchorage, Alaska; the Neisseria and Streptococcus Reference Laboratory at Statens Serum Institut in Copenhagen, Denmark; the Department of Clinical Microbiology, Landspitali in Reykjavik, Iceland; and Public Health Agency of Canada’s National Microbiology Laboratory in Winnipeg, Manitoba. From 2009 to 2020, 140 isolates of S. pneumoniae were distributed among the six laboratories as part of the quality control program. Overall serotype concordance was 96.9%, with 99.3% concordance to pool level. All participating laboratories had individual concordance rates >92% for serotype and >97% for pool. Overall concordance by modal minimum inhibitory concentration (MIC) for testing done by broth microdilution or Etest was 99.1%, and >98% for all antimicrobials tested. Categorical concordance was >98% by both CLSI and EUCAST criteria. For two laboratories performing disc diffusion, rates of concordance by modal MIC were >97% for most antimicrobials, except chloramphenicol (>93%) and trimethoprim/sulfamethoxazole (>88%). Data collected from 12 years of the ICS quality control program for S. pneumoniae demonstrate excellent (≥95%) overall concordance for serotype and antimicrobial susceptibility testing results across six laboratories.IMPORTANCEArctic populations experience several social and physical challenges that lead to the increased spread and incidence of invasive diseases. The International Circumpolar Surveillance (ICS) program was developed to monitor five invasive bacterial diseases in Arctic countries and territories. Each ICS organism has a corresponding interlaboratory quality control (QC) program for laboratory-based typing, to ensure the technical precision and accuracy of reference testing services for these regions, and identify and correct potential problems. Here, we describe the results of the ICS Streptococcus pneumoniae QC program, from 2009 to 2020. Excellent overall concordance was achieved for serotype and antimicrobial susceptibility testing results across six laboratories. Ongoing participation in these QC programs ensures the continuation of quality surveillance systems within Arctic populations that experience health disparities.
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- 2024
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81. Combining postgraduate research training, public engagement, and primary school science education—a Superbugs Master (MSc) class
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Jonathan Mark Tyrrell, Haritha Udayan Ayanikkad, Vasudev Nalleppillil-Gopakumar, Rachel Oyebode, Chiamaka Nnamdi Blessing, Sarah Hatch, and Matthias Eberl
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public engagement ,school education ,antimicrobial resistance ,microbiology ,infection ,hygiene ,Microbiology ,QR1-502 - Abstract
Since 2018, the ‘Superbugs’ initiative at Cardiff University (United Kingdom) has been delivering projects that take a research-driven approach to public engagement, involving rigorous evaluation of the methodologies of delivery and the mechanics of communication. The overall aim of Superbugs is to raise awareness and improve public knowledge of microbiology, infection and antimicrobial resistance (AMR). In the present project, four postgraduate students were recruited to undertake research projects as part of their Master of Science (MSc) studies. After a period of literature appraisals, the students chose to focus on the topic of personal and food hygiene and were tasked with collecting information on effective strategies for educating young children. Taking advantage of a focus group of primary school teachers, the students then designed evidence-informed educational activities and the evaluation strategies by which the impact of these would be assessed. A pilot delivery of these activities was carried out in a community setting at a local public library, before final delivery as part of a school outreach workshop. The MSc students produced three new elements of educational material; a story book, a treasure hunt and an interactive card game, primarily built around the concepts of challenge and gamification. Feedback collected from primary school pupils aged 6–7 years old and teachers indicated that the activities developed were successful in both being engaging to young people and resulting in an improved knowledge on the chosen topics. Taken together, we present evidence that postgraduate research training, underpinned by active and service learning, represents a valid and effective way of delivering impactful public engagement. In turn, the experience holds benefit for the students not only in terms of their academic study and core scientific skills, but also their wider appreciation and confidence in being effective engagers and science communicators.
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- 2024
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82. User-Centered Framework for Implementation of Technology (UFIT): Development of an Integrated Framework for Designing Clinical Decision Support Tools Packaged With Tailored Implementation Strategies
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Jessica Ray, Emily Benjamin Finn, Hollyce Tyrrell, Carlin F Aloe, Eliana M Perrin, Charles T Wood, Dean S Miner, Randall Grout, Jeremy J Michel, Laura J Damschroder, and Mona Sharifi
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundElectronic health record–based clinical decision support (CDS) tools can facilitate the adoption of evidence into practice. Yet, the impact of CDS beyond single-site implementation is often limited by dissemination and implementation barriers related to site- and user-specific variation in workflows and behaviors. The translation of evidence-based CDS from initial development to implementation in heterogeneous environments requires a framework that assures careful balancing of fidelity to core functional elements with adaptations to ensure compatibility with new contexts. ObjectiveThis study aims to develop and apply a framework to guide tailoring and implementing CDS across diverse clinical settings. MethodsIn preparation for a multisite trial implementing CDS for pediatric overweight or obesity in primary care, we developed the User-Centered Framework for Implementation of Technology (UFIT), a framework that integrates principles from user-centered design (UCD), human factors/ergonomics theories, and implementation science to guide both CDS adaptation and tailoring of related implementation strategies. Our transdisciplinary study team conducted semistructured interviews with pediatric primary care clinicians and a diverse group of stakeholders from 3 health systems in the northeastern, midwestern, and southeastern United States to inform and apply the framework for our formative evaluation. ResultsWe conducted 41 qualitative interviews with primary care clinicians (n=21) and other stakeholders (n=20). Our workflow analysis found 3 primary ways in which clinicians interact with the electronic health record during primary care well-child visits identifying opportunities for decision support. Additionally, we identified differences in practice patterns across contexts necessitating a multiprong design approach to support a variety of workflows, user needs, preferences, and implementation strategies. ConclusionsUFIT integrates theories and guidance from UCD, human factors/ergonomics, and implementation science to promote fit with local contexts for optimal outcomes. The components of UFIT were used to guide the development of Improving Pediatric Obesity Practice Using Prompts, an integrated package comprising CDS for obesity or overweight treatment with tailored implementation strategies. Trial RegistrationClinicalTrials.gov NCT05627011; https://clinicaltrials.gov/study/NCT05627011
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- 2024
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83. Women and Temperance in International Perspective
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Tyrrell, Ian, primary
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- 2023
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84. Renormalized Area for Minimal Hypersurfaces of 5D Poincar\'e-Einstein Spaces
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Tyrrell, Aaron J.
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Mathematics - Differential Geometry ,Mathematical Physics ,53C40, 81T35, 53C18 - Abstract
In this paper we derive a Gauss-Bonnet formula for the renormalized area of Graham-Witten minimal hypersurfaces of 5-dimensional Poincar\'e-Einstein spaces. The formula we derive expresses the renormalized area in terms of integrals of pointwise scalar Riemannian invariants. We also prove a result which gives a characterization of minimal hypersurfaces with $L^2$ second fundamental form in terms of conformal geometry at infinity., Comment: Typos have been fixed and the second main result has been re-phrased in order to emphasize the fact that it gives a characterization of minimal hypersurfaces with $L^2$ second fundamental form
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- 2022
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85. Posteroinferior glenosphere positioning is associated with improved range of motion following reverse shoulder arthroplasty with a 135° inlay humeral component and lateralized glenoid
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Lin, Albert, Romeo, Anthony, Shah, Anup, Bedi, Asheesh, Parsons, Bradford, Erickson, Brandon, Miller, Bruce, O’Grady, Christopher, Davis, Daniel, Lutton, David, Petre, Dirk, Griffin, Justin, Steinbeck, Joern, Tokish, John, Lee, Julia, Farmer, Kevin, Provencher, Matthew, Bercik, Michael, Kissenberth, Michael, Raiss, Patric, Habermeyer, Peter, Creighton, Robert, Huffman, Russell, Harmsen, Sam, Lichtenberg, Sven, Lenters, Tim, Burrus, Tyrrell, Brolin, Tyler, Pak, Theresa, Ardebol, Javier, Kilic, Ali I., Sears, Benjamin W., Lederman, Evan, Werner, Brian C., Moroder, Philipp, and Denard, Patrick J.
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- 2024
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86. TWrist: An agile compliant 3-DoF tensegrity joint
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Wang, Tianyuan, Post, Mark A., and Tyrrell, Andy M.
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- 2024
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87. Investigating Labrador Sea's persistent surface O2 anomaly using observations and biogeochemical model results
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Silva, Amavi N., Purdie, Duncan A., Bates, Nicholas R., and Tyrrell, Toby
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- 2024
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88. Seasonal timing of surgery does not affect clinical outcomes in total shoulder arthroplasty
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Shah, Anup, Bedi, Asheesh, Parsons, Bradford, Miller, Bruce, O'Grady, Christopher, Davis, Daniel, Lutton, David, Steinbeck, Joern, Tokish, John, Lee, Julia, Farmer, Kevin, Provencher, Matthew, Bercik, Michael, Kissenberth, Michael, Raiss, Patric, Habermeyer, Peter, Moroder, Philipp, Huffman, Russell, Harmsen, Samuel, Burrus, Tyrrell, Brolin, Tyler, Romeo, Anthony, Creighton, R. Alexander, Griffin, Justin W., Lin, Albert, Petre, Dirk, Erickson, Brandon J., Denard, Patrick J., Gobezie, Reuben, Lederman, Evan, Sears, Ben, and Werner, Brian C.
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- 2024
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89. Limited preoperative forward flexion does not impact outcomes between anatomic or reverse shoulder arthroplasty for primary glenohumeral arthritis
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Shah, Anup, Bedi, Asheesh, Parsons, Bradford, Erickson, Brandon, Miller, Bruce, O’Grady, Christopher, Davis, Daniel, Lutton, David, Steinbeck, Joern, Tokish, John, Lee, Julia, Farmer, Kevin, Provencher, Matthew, Bercik, Michael, Kissenberth, Michael, Raiss, Patric, Habermeyer, Peter, Moroder, Philipp, Huffman, Russell, Harmsen, Samuel, Burrus, Tyrrell, Brolin, Tyler, Romeo, Anthony, Creighton, R. Alexander, Griffin, Justin W., Lin, Albert, Petre, Dirk, Lenters, Timothy, Sears, Benjamin W., Denard, Patrick J., Lederman, Evan, Gobezie, Reuben, and Werner, Brian C.
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- 2024
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90. Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes
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Maria Carolina Borges, Gemma L. Clayton, Rachel M. Freathy, Janine F. Felix, Alba Fernández-Sanlés, Ana Gonçalves Soares, Fanny Kilpi, Qian Yang, Rosemary R. C. McEachan, Rebecca C. Richmond, Xueping Liu, Line Skotte, Amaia Irizar, Andrew T. Hattersley, Barbara Bodinier, Denise M. Scholtens, Ellen A. Nohr, Tom A. Bond, M. Geoffrey Hayes, Jane West, Jessica Tyrrell, John Wright, Luigi Bouchard, Mario Murcia, Mariona Bustamante, Marc Chadeau-Hyam, Marjo-Riitta Jarvelin, Martine Vrijheid, Patrice Perron, Per Magnus, Romy Gaillard, Vincent W. V. Jaddoe, William L. Lowe, Bjarke Feenstra, Marie-France Hivert, Thorkild I. A. Sørensen, Siri E. Håberg, Sylvain Serbert, Maria Magnus, and Deborah A. Lawlor
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Pregnancy ,Body mass index ,Triangulation ,Mendelian randomisation ,Medicine - Abstract
Abstract Background Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear. Methods We explored the relation of maternal pre-/early-pregnancy BMI with 20 pregnancy and perinatal outcomes by integrating evidence from three different approaches (i.e. multivariable regression, Mendelian randomisation, and paternal negative control analyses), including data from over 400,000 women. Results All three analytical approaches supported associations of higher maternal BMI with lower odds of maternal anaemia, delivering a small-for-gestational-age baby and initiating breastfeeding, but higher odds of hypertensive disorders of pregnancy, gestational hypertension, preeclampsia, gestational diabetes, pre-labour membrane rupture, induction of labour, caesarean section, large-for-gestational age, high birthweight, low Apgar score at 1 min, and neonatal intensive care unit admission. For example, higher maternal BMI was associated with higher risk of gestational hypertension in multivariable regression (OR = 1.67; 95% CI = 1.63, 1.70 per standard unit in BMI) and Mendelian randomisation (OR = 1.59; 95% CI = 1.38, 1.83), which was not seen for paternal BMI (OR = 1.01; 95% CI = 0.98, 1.04). Findings did not support a relation between maternal BMI and perinatal depression. For other outcomes, evidence was inconclusive due to inconsistencies across the applied approaches or substantial imprecision in effect estimates from Mendelian randomisation. Conclusions Our findings support a causal role for maternal pre-/early-pregnancy BMI on 14 out of 20 adverse pregnancy and perinatal outcomes. Pre-conception interventions to support women maintaining a healthy BMI may reduce the burden of obstetric and neonatal complications. Funding Medical Research Council, British Heart Foundation, European Research Council, National Institutes of Health, National Institute for Health Research, Research Council of Norway, Wellcome Trust.
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- 2024
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91. Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study
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WD Thompson, RM Reynolds, RN Beaumont, NM Warrington, J Tyrrell, AR Wood, DM Evans, TJ McDonald, AH Hattersley, RM Freathy, DA Lawlor, and MC Borges
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UK Biobank ,EFSOCH ,Cortisol ,Birth weight ,Mendelian Randomization ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Observational studies and randomized controlled trials have found evidence that higher maternal circulating cortisol levels in pregnancy are associated with lower offspring birth weight. However, it is possible that the observational associations are due to residual confounding. Methods We performed two-sample Mendelian Randomisation (MR) using a single genetic variant (rs9989237) associated with morning plasma cortisol (GWAS; sample 1; N = 25,314). The association between this maternal genetic variant and offspring birth weight, adjusted for fetal genotype, was obtained from the published EGG Consortium and UK Biobank meta-analysis (GWAS; sample 2; N = up to 406,063) and a Wald ratio was used to estimate the causal effect. We also performed an alternative analysis using all GWAS reported cortisol variants that takes account of linkage disequilibrium. We also tested the genetic variant’s effect on pregnancy cortisol and performed PheWas to search for potential pleiotropic effects. Results The estimated effect of maternal circulating cortisol on birth weight was a 50 gram (95% CI, -109 to 10) lower birth weight per 1 SD higher log-transformed maternal circulating cortisol levels, using a single variant. The alternative analysis gave similar results (-33 grams (95% CI, -77 to 11)). The effect of the cortisol variant on pregnancy cortisol was 2-fold weaker than in the original GWAS, and evidence was found of pleiotropy. Conclusions Our findings provide some evidence that higher maternal morning plasma cortisol causes lower birth weight. Identification of more independent genetic instruments for morning plasma cortisol are necessary to explore the potential bias identified.
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- 2024
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92. Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood
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Hawkes, Gareth, Beaumont, Robin N., Tyrrell, Jessica, Power, Grace M., Wood, Andrew, Laakso, Markku, Fernandes Silva, Lilian, Boehnke, Michael, Yin, Xianyong, Richardson, Tom G., Smith, George Davey, and Frayling, Timothy M.
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- 2023
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93. Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study
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Francesco Casanova, Jessica O’Loughlin, Vasilis Karageorgiou, Robin N. Beaumont, Jack Bowden, Andrew R. Wood, and Jessica Tyrrell
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Mental health ,Well-being ,Physical activity ,Mendelian randomisation ,Medicine - Abstract
Abstract Background Mental health conditions represent one of the major groups of non-transmissible diseases. Physical activity (PA) and sedentary time (ST) have been shown to affect mental health outcomes in opposite directions. In this study, we use accelerometery-derived measures of PA and ST from the UK Biobank (UKB) and depression, anxiety and well-being data from the UKB mental health questionnaire as well as published summary statistics to explore the causal associations between these phenotypes. Methods We used MRlap to test if objectively measured PA and ST associate with mental health outcomes using UKB data and summary statistics from published genome-wide association studies. We also tested for bidirectional associations. We performed sex stratified as well as sensitivity analyses. Results Genetically instrumented higher PA was associated with lower odds of depression (OR = 0.92; 95% CI: 0.88, 0.97) and depression severity (beta = − 0.11; 95% CI: − 0.18, − 0.04), Genetically instrumented higher ST was associated higher odds of anxiety (OR = 2.59; 95% CI: 1.10, 4.60). PA was associated with higher well-being (beta = 0.11, 95% CI: 0.04; 0.18) and ST with lower well-being (beta = − 0.18; 95% CI: − 0.32, − 0.03). Similar findings were observed when stratifying by sex. There was evidence for a bidirectional relationship, with higher genetic liability to depression associated with lower PA (beta = − 0.25, 95% CI: − 0.42; − 0.08) and higher well-being associated with higher PA (beta = 0.15; 95% CI: 0.05, 0.25). Conclusions We have demonstrated the bidirectional effects of both PA and ST on a range of mental health outcomes using objectively measured predictors and MR methods for causal inference. Our findings support a causal role for PA and ST in the development of mental health problems and in affecting well-being.
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- 2023
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94. The genetics of falling susceptibility and identification of causal risk factors
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Matt C. Smith, Jessica O’Loughlin, Vasileios Karageorgiou, Francesco Casanova, Genevieve K. R. Williams, Malcolm Hilton, and Jessica Tyrrell
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Medicine ,Science - Abstract
Abstract Falls represent a huge health and economic burden. Whilst many factors are associated with fall risk (e.g. obesity and physical inactivity) there is limited evidence for the causal role of these risk factors. Here, we used hospital and general practitioner records in UK Biobank, deriving a balance specific fall phenotype in 20,789 cases and 180,658 controls, performed a Genome Wide Association Study (GWAS) and used Mendelian Randomisation (MR) to test causal pathways. GWAS indicated a small but significant SNP-based heritability (4.4%), identifying one variant (rs429358) in APOE at genome-wide significance (P
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- 2023
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95. The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism
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Elena Arutyunova, Alexandr Belovodskiy, Pu Chen, Muhammad Bashir Khan, Michael Joyce, Holly Saffran, Jimmy Lu, Zoe Turner, Bing Bai, Tess Lamer, Howard S. Young, John C. Vederas, D. Lorne Tyrrell, M. Joanne Lemieux, and James A. Nieman
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Biology (General) ,QH301-705.5 ,Biochemistry ,QD415-436 - Published
- 2023
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96. Author Correction: [18F]FSPG-PET provides an early marker of radiotherapy response in head and neck squamous cell cancer
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Khrishanthne Sambasivan, Will E. Tyrrell, Rizwan Farooq, Jenasee Mynerich, Richard S. Edwards, Muhammet Tanc, Teresa Guerrero Urbano, and Timothy H. Witney
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Medical technology ,R855-855.5 ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Published
- 2024
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97. Changes in Cyanobacterial Phytoplankton Communities in Lake-Water Mesocosms Treated with Either Glucose or Hydrogen Peroxide
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David Linz, Charlyn G. Partridge, Michael C. Hassett, Nathan Sienkiewicz, Katie Tyrrell, Aimèe Henderson, Renee Tardani, Jingrang Lu, Alan D. Steinman, and Stephen Vesper
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cyanobacteria ,glucose ,hydrogen peroxide ,mesocosm ,freshwater ,Biology (General) ,QH301-705.5 - Abstract
When cyanobacterial phytoplankton form harmful cyanobacterial blooms (HCBs), the toxins they produce threaten freshwater ecosystems. Hydrogen peroxide is often used to control HCBs, but it is broadly toxic and dangerous to handle. Previously, we demonstrated that glucose addition to lake water could suppress the abundance of cyanobacteria. In this study, glucose was compared to hydrogen peroxide for the treatment of cyanobacterial phytoplankton communities. The six-week study was conducted in the large mesocosms facility at Grand Valley State University’s Annis Water Resources Institute in Michigan. To 1000 L of Muskegon Lake water, glucose was added at either 150 mg or 30 mg glucose/L. Hydrogen peroxide was added at 3 mg/L to two 1000 L mesocosms. And two mesocosms were left untreated as controls. Triplicate 100 mL samples were collected weekly from each mesocosm, which were then filtered and frozen at −80 °C for 16S rRNA amplicon sequencing. The 16S rRNA amplicon sequencing results revealed that hydrogen peroxide treatment quickly reduced the relative abundance of the cyanobacteria compared to the control mesocosms, but the cyanobacteria population returned over the course of the 6-week study. On the other hand, both glucose concentrations caused a rapid proliferation of multiple low abundance proteobacterial and bacteroidotal taxa resulting in notable increases in taxonomic richness over the duration of the study and reducing the relative abundance of cyanobacteria. Although hydrogen peroxide quickly suppressed the cyanobacteria, the population later returned to near starting levels. The glucose suppressed the cyanobacterial phytoplankton apparently by promoting competitive heterotrophic bacteria.
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- 2024
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98. Investigating the Effect of Motion Capture Suits on the Test–Retest Reliability of Gait Parameters
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Matt C. Smith, Phaedra Leveridge, Garry Massey, Jessica Tyrrell, Malcolm Hilton, and Genevieve K. R. Williams
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motion capture ,intraclass correlation ,minimal detectable change ,gait analysis ,clinical biomechanics ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
When collecting marker-based motion capture data from clinical populations, speed of collection and comfort for the participant is a priority. This could be achieved by attaching markers to motion capture Velcro suits, as opposed to the skin. This study aimed to ascertain the reliability of sagittal-plane gait parameters estimated using Plug-in Gait (PiG) and Conventional Gait Model 2 (CGM2) marker sets from data collected in Suited and Non-suited (markers placed onto skin) conditions. For ten participants, markers were placed based on PiG and CGM2 models and data captured during a 2-min treadmill walk. Trials were repeated in suited and non-suited conditions. PiG ankle flexion/extension measurements had poor/moderate reliability (Non-suited ICC = 0.531, Suited ICC = 0.435). CGM2 ankle flexion/extension measurements had good/excellent reliability (Non-suited ICC = 0.916, Suited ICC = 0.900). There were significant differences in minimal detectable change (MDC) between conditions at the ankle for PiG (Non-suited MDC = 2.32°, Suited MDC = 18.90°), but not for CGM2 (Non-suited MDC = 0.63°, Suited MDC = 0.95°). When using CGM2, knee (Non-suited ICC = 0.878, Suited ICC = 0.855) and hip (Non-suited ICC = 0.897, Suited ICC = 0.948) showed good/excellent reliability in both conditions. A motion capture suit is not a reliable solution when collecting joint angle data using the PiG model but is reliable enough to consider when using the CGM2 model.
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- 2024
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99. Finite undecidability in PAC and PRC fields
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Tyrrell, Brian
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- 2024
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100. Should I Stay (in School) or Should I Go (to Work)
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Tyrrell-Hendry, Lee
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- 2024
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