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The fragmentation of the Adriatic plate and the sinking of the remnant Alpine Tethys and Ionian lithosphere give rise to passive subduction processes that, together with the collision of the African and European plates, characterize the Central Mediterranean area. Circum - Mediterranean mountain ranges and Alboran, Balearic, Tyrrhenian and Hellenic back-arc basins are formed in this complex deformation system. The evolution of the geodynamic processes that guided the opening of the Tyrrhenian basin and the contemporary formation of the Apennine chain are described in this work using the plate kinematics technique. The study area has been divided into polygons (crustal blocks of microplates) after careful observation of the regional structures. The polygons are distinguished on the basis of the direction of the Tyrrhenian extension and the boundaries between them coincide with the large structures that characterize the Tyrrhenian-Apennine area. The Tyrrhenian extension directions are indicators of the Euler poles of the individual polygons, in the Sardo-Corso block reference frame. The velocity ratios were determined by the slip vectors of the structures (plate boundaries) that separates the polygons. The rotation time and angle are determined respectively: using the stratigraphic records of the syn-rift sequences and comparing the crustal balance with the speed ratios. At the end including the new kinematic framework in the global rotation model we were able to reconstruct the tectonic evolution of the central Mediterranean during the opening of the Tyrrhenian basin.

Sicily is in the centre of an area where complex geodynamic processes work together, these are: the Tyrrhenian-Apennine System evolution, the African-Ionian slab subduction and Africa-Europe collision. During the last 5 Ma it was involved in a process of escape towards east-southeast: while on one side Africa acted as an intender pushing toward north, on the other side the fragmentation and retreat of the African-Ionian slab created space to the east. The aim of this study is to reconstruct the kinematic evolution of Sicily, here considered as an independent plate starting from 5 Ma ago, and its role in the context of the Tyrrhenian-Apennine system. The plates and microplate involved in the evolution are Europe, Africa and Calabria. The boundaries between these and Sicily are the margin of the Sicily microplate and are lithospheric structures known from the literature and identifiable from high resolution bathymetric maps, seismic sections, geodetic data, focal mechanism of recent earthquakes, gravimetric maps, lithosphere thickness maps and so on. Briefly the margin between Sicily and Europe is along the Elimi chain, a E-W trending morpho-structure with transpressive kinematics, the margin with Calabria microplate is along the right-lateral Taormina line and the margin with Africa is expressed along the Malta Escarpment, south of Etna Mount, with transpressive kinematics and along the Sicily Channel, where a series of troughs (Pantelleria, Linosa and Malta) were interpreted in literature as pull-apart basins related to a dextral trascurrent zone. The Euler pole of rotation between Sicily and Africa was found starting from the structures in the Sicily Channel and using the GPlates software, then we were able to find also Sicily-Europe and Sicily-Calabria poles and the respective velocity vectors and to compare these with the geological data and better refine the model.

We describe the opening of back-arc basins and the associated formation of accretionary wedges through the application of techniques of deformable plate kinematics. These methods have proven to be suitable to describe complex tectonic processes, such as those that are observed along the Africa–Europe collision belt. In the central Mediterranean area, these processes result from the passive subduction of the lithosphere belonging to the Alpine Tethys and Ionian Ocean. In particular, we focus on the opening of the Tyrrhenian basin and the contemporary formation of the Apennine chain. We divide the area of the Apennine Chain and the Tyrrhenian basin into deformable polygons that are identified on the basis of sets of extensional structures that are coherent with unique Euler pole grids. The boundaries between these polygons coincide with large tectonic lineaments that characterize the Tyrrhenian–Apennine area. The tectonic style along these structures reflects the variability of relative velocity vectors between two adjacent blocks. The deformation of tectonic elements is accomplished, allowing different rotation velocities of lines that compose these blocks about the same stable stage poles. The angular velocities of extension are determined on the basis of the stratigraphic records of syn-rift sequences, while the rotation angles are obtained by crustal balancing.

This corrects the article DOI: 10.1038/ncomms14797.

One-atom-thick rare-earth/noble metal (RE-NM) compounds are attractive materials to investigate two-dimensional magnetism, since they are easy to synthesize into a common RE-NM2 structure with high crystal perfection. Here we perform a comparative study of the GdAu2, HoAu2, and YbAu2 monolayer compounds grown on Au(111). We find the same atomic lattice quality and moire superlattice periodicity in the three cases, but different electronic properties and magnetism. The YbAu2 monolayer reveals the characteristic electronic signatures of a mixed-valence configuration in the Yb atom. In contrast, GdAu2 and HoAu2 show the trivalent character of the rare-earth and ferromagnetic transitions below 22 K. Yet, the GdAu2 monolayer has an in-plane magnetic easy-axis, versus the out-of-plane one in HoAu2. The electronic bands of the two trivalent compounds are very similar, while the divalent YbAu2 monolayer exhibits different band features. In the latter, a strong 4f-5d hybridization is manifested in neatly resolved avoided crossings near the Fermi level. First principles theory points to a residual presence of empty 4f states, explaining the fluctuating valence of Yb in the YbAu2 monolayer.

One-atom-thick rare-earth/noble metal (RE-NM) compounds are attractive materials to investigate two-dimensional magnetism, since they are easy to synthesize into a common RE-NM2 structure with high crystal perfection. Here we perform a comparative study of the GdAu2, HoAu2, and YbAu2 monolayer compounds grown on Au(111). We find the same atomic lattice quality and moiré superlattice periodicity in the three cases, but different electronic properties and magnetism. The YbAu2 monolayer reveals the characteristic electronic signatures of a mixed-valence configuration in the Yb atom. In contrast, GdAu2 and HoAu2 show the trivalent character of the rare-earth and ferromagnetic transitions below 22 K. Yet, the GdAu2 monolayer has an in-plane magnetic easy-axis, versus the out-of-plane one in HoAu2. The electronic bands of the two trivalent compounds are very similar, while the divalent YbAu2 monolayer exhibits different band features. In the latter, a strong 4f–5d hybridization is manifested in neatly resolved avoided crossings near the Fermi level. First principles theory points to a residual presence of empty 4f states, explaining the fluctuating valence of Yb in the YbAu2 monolayer.

The Africa Europe collision, which produces the formation of the Alpine arc, in the Mediterranean area is accompanied by passive subduction processes, resulting from the sinking of the remnant Alpine Tethys and the Ionian lithosphere, and from the fragmentation of the Adriatic plate. In this complex deformation, back-arc basins (Alboran, Balearic, Tyrrhenian and Hellenic) and circum - Mediterranean mountain ranges are formed. In this work we focus our attention on the opening of the Tyrrhenian basin and the contemporary formation of the Apennine chain. In order to describe the evolution of the geodynamic processes that guided the formation of the Tyrrhenian basin and the Apennine chain we used the plate kinematics technique. Through careful observation of the regional structures we have divided the area of the Apennine Chain and the Tyrrhenian basin into polygons (crustal blocks or microplates) distinguished on the basis of the direction of the Tyrrhenian extension. The boundary between the polygons has been placed coinciding with the large structures that characterize the Tyrrhenian-Apennine area. The rotation poles of the individual polygons, in the frame of reference of the Sardo-Corso block, are based on the Tyrrhenian extension directions that characterize them. The velocity ratio between the polygons was determined by the slip vector of the structure (plate boundary) that separates them. To determine the rotation time of the polygons we used the stratigraphic records of the syn-rift sequences, while the rotation angle of the polygons is obtained comparing the crustal balance with the speed ratios. Finally, the kinematic framework obtained, included in the global rotation model, allowed us to reconstruct the tectonic evolution of the central Mediterranean during the opening of the Tyrrhenian basin.

The complex processes affecting the Tyrrhenian-Apennine System are inevitably reflected in Sicily, here considered as an independent plate starting from 5 Ma and located between Europe and Africa plates and Calabria microplate. In particular the retreat of the Adriatic-Ionian slab and its fragmentation involve Sicily in a process of escape towards east-southeast due to the space that the slab is creating. At the same time Africa acts as an intender during its convergence with the European plate. We show here the preliminary results of a study that aims to reconstruct the kinematic evolution of Sicily and its role in the framework of the Tyrrhenian-Apennine System. First of all we found the margins of the plate, searching for lithospheric structures that can be considered as plate boundaries, using different types of data (high resolution bathymetric maps, seismic sections, geodetic data, focal mechanism of recent earthquakes, gravimetric maps, lithosphere thickness maps¿) together with the literature. The margins are: -The Sicily Channel, characterized by a series of pull-apart basins related to a dextral trascurrent zone (Sicily-Africa margin); -The Malta escarpment and the Taormina Line characterized by transpression (Sicily-Calabria margin); -The Drepano-Ustica seamount also characterized by transpression (Sicily Europe margin). Starting from the structures in the Sicily Channel, we found the Euler pole of rotation between Sicily and Africa using the GPlates software. Thanks to the software we were able to find also Sicily-Europe and Sicily-Calabria poles and the velocity vectors. Finally, we compared the Euler poles and the velocity vectors with the geological data, trying the best fit of the two and better refine the model.

The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-positive status associates with a significantly lower probability of developing a distant event, and a clear difference in survival. p140Cap dampens ERBB2-positive tumour cell progression, impairing tumour onset and growth in the NeuT mouse model, and counteracting epithelial mesenchymal transition, resulting in decreased metastasis formation. One major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. Our findings point to a specific role of p140Cap in curbing the aggressiveness of ERBB2-amplified breast cancers and suggest that, due to its ability to impinge on specific molecular pathways, p140Cap may represent a predictive biomarker of response to targeted anti-ERBB2 therapies

CHRNA7, encoding the neuronal alpha7 nicotinic acetylcholine receptor (a7nAChR), is highly expressed in the brain, particularly in the hippocampus. It is situated in the 15q13.3 chromosome region, frequently associated with a Copy Number Variation (CNV), which causes its duplication or deletion. The clinical significance of CHRNA7 duplications is unknown so far, but there are several research data suggesting that they may be pathogenic, with reduced penetrance. We have produced an iPS cell line from a single healthy donor's fibroblasts carrying a 15q13.3 CNV, including CHRNA7 in order to study the exact role of this CNV during the neurodevelopment.

Joubert Syndrome (JS) is a rare autosomal recessive or X-linked condition characterized by a peculiar cerebellar malformation, known as the molar tooth sign (MTS), associated with other neurological phenotypes and multiorgan involvement. JS is a ciliopathy, a spectrum of disorders whose causative genes encode proteins involved in the primary cilium apparatus. In order to elucidate ciliopathy-associated molecular mechanisms, human induced pluripotent stem cells (hiPSCs) were derived from a patient affected by JS carrying a homozygous missense mutation in the AHI1 gene (p.H896R) that encodes a protein named Jouberin

Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by developmental delay, behavioural problems and circadian rhythm dysregulation. About 90% of SMS cases are due to a 17p11.2 deletion containing retinoic acid induced1 (RAI1) gene, 10% are due to heterozygous mutations affecting RAI1 coding region. Little is known about RAI1 role