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51. Corrigendum to 'What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021' [Eur Urol 2022]

Author

Turco, Fabio, Armstrong, Andrew, Attard, Gerhardt, Beer, Tomasz M, Beltran, Himisha, Bjartell, Anders, Bossi, Alberto, Briganti, Alberto, Bristow, Rob G, Bulbul, Muhammad, Caffo, Orazio, Chi, Kim N, Clarke, Caroline, Clarke, Noel, Davis, Ian D, de Bono, Johann, Duran, Ignacio, Eeles, Ros, Efstathiou, Eleni, Efstathiou, Jason, Evans, Christopher P, Fanti, Stefano, Feng, Felix Y, Fizazi, Karim, Frydenberg, Mark, George, Dan, Gleave, Martin, Halabi, Susan, Heinrich, Daniel, Higano, Celestia, Hofman, Michael S, Hussain, Maha, James, Nicholas, Jones, Rob, Kanesvaran, Ravindran, Khauli, Raja B, Klotz, Laurence, Leibowitz, Raya, Logothetis, Christopher, Maluf, Fernando, Millman, Robin, Morgans, Alicia K, Morris, Michael J, Mottet, Nicolas, Mrabti, Hind, Murphy, Declan G, Murthy, Vedang, Oh, William K, Ekeke, Onyeanunam Ngozi, Ost, Piet, O'Sullivan, Joe M, Padhani, Anwar R, Parker, Christopher, Poon, Darren M C, Pritchard, Colin C, Rabah, Danny M, Rathkopf, Dana, Reiter, Robert E, Rubin, Mark, Ryan, Charles J, Saad, Fred, Sade, Juan Pablo, Sartor, Oliver, Scher, Howard I, Shore, Neal, Skoneczna, Iwona, Small, Eric, Smith, Matthew, Soule, Howard, Spratt, Daniel, Sternberg, Cora N, Suzuki, Hiroyoshi, Sweeney, Christopher, Sydes, Matthew, Taplin, Mary-Ellen, Tilki, Derya, Tombal, Bertrand, Türkeri, Levent, Uemura, Hiroji, Uemura, Hirotsugu, van Oort, Inge, Yamoah, Kosj, Ye, Dingwei, Zapatero, Almudena, Gillessen, Silke, Omlin, Aurelius, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, and UCL - (SLuc) Service d'urologie

Subjects
610 Medicine & health, 610 Medizin und Gesundheit
Published
2022
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52. New Perspectives in the Medical Treatment of Non-Muscle-Invasive Bladder Cancer: Immune Checkpoint Inhibitors and Beyond

Author

Audisio, Alessandro, primary, Buttigliero, Consuelo, additional, Delcuratolo, Marco Donatello, additional, Parlagreco, Elena, additional, Audisio, Marco, additional, Ungaro, Antonio, additional, Di Stefano, Rosario Francesco, additional, Di Prima, Lavinia, additional, Turco, Fabio, additional, and Tucci, Marcello, additional

Published
2022
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56. Role of radium-223 discontinuation due to adverse events in castration-resistant prostate cancer patients. A retrospective monocentric analysis

Author

Turco, Fabio, Tucci, Marcello, Angusti, Tiziana, Parente, Antonella, Di Stefano, Rosario Francesco, Urban, Susanna, Pisano, Chiara, Samuelly, Alessandro, Audisio, Alessandro, Audisio, Marco, Parlagreco, Elena, Ungaro, Antonio, Scagliotti, Giorgio Vittorio, Di Maio, Massimo, and Buttigliero, Consuelo

Abstract

Background: Radium 223 (Ra-223) was approved for the treatment of metastatic castration resistant prostate cancer (mCRPC) patients with bone-only disease, following demonstration of significant improvement in overall survival (OS). To date, there are no validated prognostic factors useful in predicting outcome of mCRPC patients treated with Ra-223. Our retrospective study aims to evaluate the prognostic role of treatment discontinuation due to adverse events in mCRPC patients treated with Ra-223, and to identify which factors correlate with the toxicity onset.Methods: We performed a retrospective analysis of all consecutive mCRPC patients treated with Ra-223 from September 2013 to December 2019 at our institute. Patients were divided in 2 groups according to the reason of Ra-223 therapy discontinuation: toxicity versus other causes. Outcome measures were progression-free survival (PFS) and OS.Results: In the overall population (75 patients) median PFS and OS were 5.46 months and 11.15 months respectively. Patients who discontinued treatment due to toxicity had a lower median PFS (3.49 vs 5.89 months, HR: 1.88, 95% CI: 1.14-3.12, p= 0.014) and OS (8.59 vs 14.7 months HR: 3.33, 95% CI: 1.85-6.01, p< 0.001) than patients who discontinued therapy due to other causes. The risk of Ra-223 discontinuation due to toxicity correlates with the number of previous treatments (p= 0.002), previous chemotherapy treatment (p= 0.039), baseline LDH (p= 0.012), Hb (p= 0.021) and platelet-to-lymphocyte ratio (p= 0.024).Conclusions: Discontinuation due to toxicity is associated with worse outcomes in mCRPC patients treated with Ra-223. To reduce the risk of developing toxicities that may compromise treatment efficacy, Ra-223 should be used early in mCRPC patients.

Published
2023
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61. Safety profile of darolutamide versus placebo: a systematic review and meta-analysis

Author

Turco, Fabio, Gillessen, Silke, Treglia, Giorgio, Fizazi, Karim, Smith, Matthew R., Tombal, Bertrand, Cathomas, Richard, Buttigliero, Consuelo, Di Maio, Massimo, Tucci, Marcello, and Vogl, Ursula M.

Abstract

Background: Darolutamide is an androgen receptor pathway inhibitor (ARPI) used in patients with prostate cancer (PC). In pivotal trials, it has demonstrated a favorable toxicity profile. There are no head-to-head comparison studies between the different ARPIs, but the efficacy of these drugs seems to be similar making the toxicity profile a key element for treatment selection. Methods: We conducted a systematic review of all clinical trials assessing treatment with darolutamide for patients with PC using placebo as the control using the PubMed/Medline and Cochrane library databases. We also performed a meta-analysis to compare the safety of darolutamide versus placebo evaluating adverse events (AE) leading to treatment discontinuation and the rate of the AE reported as “AE of interest” in the ARAMIS trial. The comparison among darolutamide and the placebo group in terms of safety and tolerability was performed using odds ratio (OR) as meta-analytic outcome. Results: We identified three articles comprising 2902 patients for the systematic review and meta-analysis (1652 treated with darolutamide and 1250 with placebo). Darolutamide did not increase AE leading to treatment discontinuation compared to placebo (pooled OR: 1.176, 95% CI 0.918–1.507, p= 0.633). Regarding the “AE of interest” there was no difference between darolutamide and placebo in terms of asthenia, cardiac arrhythmia, cardiac disorder, coronary artery disorder, depression mood disorder, falls, fatigue, heart failure, hot flushes, hypertension, mental-impairment disorder, rash, seizure and weight loss. The only “AE of interest” with a statistically significant difference in favor of placebo was bone fractures (pooled OR: 1.523, 95% CI 1.081–2.146). Conclusions: In our systematic review and meta-analysis, darolutamide showed a toxicity profile comparable to placebo with the exception of bone fractures. In the absence of head-to-head comparison studies between the different ARPIs, the results of our research suggest a preferred use of darolutamide in the approved settings.

Published
2023
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62. Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with metastatic castration resistant prostate cancer treated with Abiraterone or Enzalutamide

Author

Pisano, Chiara, primary, Tucci, Marcello, additional, Di Stefano, Rosario F., additional, Turco, Fabio, additional, Samuelly, Alessandro, additional, Bungaro, Maristella, additional, Vignani, Francesca, additional, Tarenghi, Federica, additional, Scagliotti, Giorgio V., additional, Di Maio, Massimo, additional, and Buttigliero, Consuelo, additional

Published
2021
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63. Prognostic role of early PSA drop in castration resistant prostate cancer patients treated with abiraterone acetate or enzalutamide

Author

Buttigliero, Consuelo, primary, Tucci, Marcello, additional, Sonetto, Cristina, additional, Vignani, Francesca, additional, Di Stefano, Rosario F., additional, Pisano, Chiara, additional, Turco, Fabio, additional, Lacidogna, Gaetano, additional, Guglielmini, Pamela, additional, Numico, Gianmauro, additional, Scagliotti, Giorgio V., additional, and Di Maio, Massimo, additional

Published
2020
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66. Corrigendum to “What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021” [Eur Urol 82(1):6–11]

Author

Turco, Fabio, Armstrong, Andrew, Attard, Gerhardt, Beer, Tomasz M., Beltran, Himisha, Bjartell, Anders, Bossi, Alberto, Briganti, Alberto, Bristow, Rob G., Bulbul, Muhammad, Caffo, Orazio, Chi, Kim N., Clarke, Caroline, Clarke, Noel, Davis, Ian D., de Bono, Johann, Duran, Ignacio, Eeles, Ros, Efstathiou, Eleni, Efstathiou, Jason, Evans, Christopher P., Fanti, Stefano, Feng, Felix Y., Fizazi, Karim, Frydenberg, Mark, George, Dan, Gleave, Martin, Halabi, Susan, Heinrich, Daniel, Higano, Celestia, Hofman, Michael S., Hussain, Maha, James, Nicholas, Jones, Rob, Kanesvaran, Ravindran, Khauli, Raja B., Klotz, Laurence, Leibowitz, Raya, Logothetis, Christopher, Maluf, Fernando, Millman, Robin, Morgans, Alicia K., Morris, Michael J., Mottet, Nicolas, Mrabti, Hind, Murphy, Declan G., Murthy, Vedang, Oh, William K., Ekeke, Onyeanunam Ngozi, Ost, Piet, O'Sullivan, Joe M., Padhani, Anwar R., Parker, Christopher, Poon, Darren M.C., Pritchard, Colin C., Rabah, Danny M., Rathkopf, Dana, Reiter, Robert E., Rubin, Mark, Ryan, Charles J., Saad, Fred, Sade, Juan Pablo, Sartor, Oliver, Scher, Howard I., Shore, Neal, Skoneczna, Iwona, Small, Eric, Smith, Matthew, Soule, Howard, Spratt, Daniel, Sternberg, Cora N., Suzuki, Hiroyoshi, Sweeney, Christopher, Sydes, Matthew, Taplin, Mary-Ellen, Tilki, Derya, Tombal, Bertrand, Türkeri, Levent, Uemura, Hiroji, Uemura, Hirotsugu, van Oort, Inge, Yamoah, Kosj, Ye, Dingwei, Zapatero, Almudena, Gillessen, Silke, and Omlin, Aurelius

Published
2022
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71. Bacterial stimuli activate nitric oxide colonic mucosal production in diverticular disease. Protective effects of L. casei DG ® ( Lactobacillus paracasei CNCM I‐1572)

Author

Turco, Fabio, primary, Andreozzi, Paolo, additional, Palumbo, Ilaria, additional, Zito, Francesco Paolo, additional, Cargiolli, Martina, additional, Fiore, Walter, additional, Gennarelli, Nicola, additional, De Palma, Giovanni Domenico, additional, Sarnelli, Giovanni, additional, and Cuomo, Rosario, additional

Published
2017
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72. Pilot Study in Human GUT Mucosal Biopsies: Severity of Disease is Predictive of Higher Levels of Acute Biologic Release of Glial S100Î' Protein in Ulcerative Colitis and Crohn's Disease

Author

Turco, Fabio, primary, Rico, Andromeda Linan, additional, Abdel-Rasoul, Mahmoud, additional, Zuleta-Alarcon, Alix, additional, Fadda, Paolo, additional, Grants, Iveta, additional, Cuomo, Rosario, additional, Arsenescu, Razvan, additional, Harzman, Alan, additional, Chen, Wei, additional, Frankel, Wendy, additional, and Christofi, Fievos L., additional

Published
2017
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74. Dobutamine Stress Echocardiography Safety in Chagas Disease Patients

Author

Rassi, Daniela do Carmo, primary, Vieira, Marcelo Luiz Campos, additional, Furtado, Rogerio Gomes, additional, Turco, Fabio de Paula, additional, Melato, Luciano Henrique, additional, Hotta, Viviane Tiemi, additional, Nunes, Colandy Godoy de Oliveira, additional, Rassi Júnior, Luiz, additional, and Rassi, Salvador, additional

Published
2017
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75. Increased severity of dyspeptic symptoms related to mental stress is associated with sympathetic hyperactivity and enhanced endocrine response in patients with postprandial distress syndrome

Author

DE GIORGI, FRANCESCO, SARNELLI, GIOVANNI, CIRILLO, CARLA, SAVINO, IVANA GIUSJ, TURCO, FABIO, NARDONE, GERARDO ANTONIO PIO, ROCCO, ALBA, CUOMO, ROSARIO, DE GIORGI, Francesco, Sarnelli, Giovanni, Cirillo, Carla, Savino, IVANA GIUSJ, Turco, Fabio, Nardone, GERARDO ANTONIO PIO, Rocco, Alba, and Cuomo, Rosario

Abstract

BACKGROUND: Mental stress (MS) may alter gastric sensory-motor function. The aim of the study was to assess postprandial autonomic nervous system activity and stress hormones in response to acute mental stress in dyspeptic patients. METHODS: A total of 25 patients with postprandial distress syndrome (PDS; 11 mol L(-1), age 35.9 ± 9.3 years) and 12 healthy controls (5 mol L(-1), age 25.8 ± 4.6 years) underwent electrogastrography and (13) C-octanoate gastric emptying study using a 480 kcal solid meal. Heart rate variability (LF/HF ratio) and corticotrophin-releasing factor, adrenocorticotropic hormone (ACTH), and cortisol serum levels were also evaluated. Dyspeptic symptoms were scored by analogue visual scale and expressed as symptoms total score (TS). The protocol was repeated twice in each subject, with and without a mental stress test before the meal. KEY RESULTS: Mental stress significantly increased postprandial symptoms severity in patients (TS: stress 111 ± 18 vs basal 50 ± 10; P < 0.05). Low-/high-frequency component ratio was significantly higher in patients after MS at 120 min (stress 5.46 ± 0.41 vs basal 3.41 ± 0.64; P < 0.01) and 180 min (stress 5.29 ± 0.2 vs basal 3.58 ± 0.19; P < 0.05). During stress session, in patients we found a significantly higher ACTH level than baseline at 30, 60, 90, 150, 210, 240, and 270 min and a significantly higher cortisol level at 30, 60, 90, 120, 210, and 270 min. Gastric emptying rate and electrical activity were not influenced by MS. CONCLUSIONS & INFERENCES: In PDS patients, administration of MS before meal increases symptoms severity by inducing sympathetic hyperactivity and increased stress hormones levels. As the gastric emptying looks not altered, we conclude that these neurohormonal responses mainly affect sensitive function. ispartof: Neurogastroenterology and Motility vol:25 issue:1 pages:31- ispartof: location:England status: published

Published
2013

76. Incidence and variables associated with arrhythmias during dobutamine–atropine stress echocardiography among patients with Chagas disease.

Author

Rassi, Salvador, Carmo Rassi, Daniela, Gomes Furtado, Rogério, Paula Turco, Fabio, Henrique Melato, Luciano, Godoy Nunes, Colandy, Rassi, Luiz, Tiemi Hotta, Viviane, and Campos Vieira, Marcelo Luiz

Subjects
ATRIAL fibrillation risk factors, CORONARY heart disease risk factors, VENTRICULAR tachycardia, SUPRAVENTRICULAR tachycardia, ARRHYTHMIA, ATROPINE, DOBUTAMINE, ECHOCARDIOGRAPHY, PATIENT safety, SERODIAGNOSIS, TRYPANOSOMIASIS, DISEASE incidence, RETROSPECTIVE studies, ODDS ratio, DISEASE risk factors
Abstract

Background: Dobutamine stress echocardiography (DSE) is an important tool in the diagnosis of coronary artery disease. However, there is hesitation in clinical practice for using it in patients with Chagas disease (CD) due to the arrhythmogenic potential of this heart condition. This study aimed to evaluate the incidence and variables associated with arrhythmias during DSE in a population of patients with CD. Methods: A population of 205 consecutive patients with CD and suspected coronary heart disease was assessed through a retrospective database analysis. CD was confirmed in all patients by serological testing. Results: The mean age of the patients selected was 64 years, and 65.4% of the patients were female. Significant arrhythmias occurred as follows: nonsustained ventricular tachycardia in 7.3% of patients; supraventricular tachycardia and sustained ventricular tachycardia in 1%; and atrial fibrillation in 0.5%. Nonsignificant arrhythmias occurred as follows: premature ventricular contractions in 48% of patients and bigeminy in 4.4%. Values for the wall‐motion score index at rest greater than 1.12 and 1.18 were independently correlated with the occurrence of nonsignificant arrhythmias (odds ratio [OR] = 2.90, P < 0.001) and significant arrhythmias (OR = 4.23, P = 0.044), respectively. Conclusion: DSE should be considered a safe examination in patients with CD despite the known increased risk of arrhythmias in this group of patients. The occurrence of arrhythmias was low in this study. Abnormal wall‐motion score index values at rest were associated with the occurrence of significant and nonsignificant arrhythmias during the test. [ABSTRACT FROM AUTHOR]

Published
2019
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77. Prognostic and Predictive Role of SPOP Mutations in Prostate Cancer: A Systematic Review and Meta-analysis

Author

Pedrani, Martino, Salfi, Giuseppe, Merler, Sara, Testi, Irene, Cani, Massimiliano, Turco, Fabio, Trevisi, Elena, Tortola, Luigi, Treglia, Giorgio, Luca Di Tanna, Gian, Vogl, Ursula, Gillessen, Silke, Theurillat, Jean-Philippe, and Pereira Mestre, Ricardo

Abstract

Speckle-type POZ (SPOP) mutations could be a favorable prognostic factor in patients with prostate cancer (PC) and may also predict better overall and progression-free survival for treatment with hormonal agents. Therefore, less intensified treatments omitting chemotherapy for patients with SPOP-mutant PC should be explored in clinical trials.

Published
2024
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78. ACETONIC EXTRACT FROM FEIJOA SELLOWIANA BERG.FRUITS INHIBITS PROLIFERATION, MODULATES BRUSH BORDERMEMBRANE ENZYMES ACTIVITIES AND PREVENT LIPID PEROXIDATIONIN HUMAN INTESTINAL EPITHELIAL CELLS

Author

TURCO, FABIO, SARNELLI, GIOVANNI, CUOMO, ROSARIO, I. Palumbo, M. Pesce, A. D’Alessandro, R. D’Aniello, T. Baldoni, T. Di Maio, V. Farina, A. Nasti, Turco, Fabio, Palumbo, I., Pesce, M., D’Alessandro, A., D’Aniello, R., Baldoni, T., Di Maio, T., Farina, V., Nasti, A., Sarnelli, Giovanni, and Cuomo, Rosario

Subjects
Feijoa sellowiana Berg. fruit, intestinal epithelial cell, lipid peroxidation
Abstract

INTRODUCTION: Feijoa sellowiana fruits grow throughout the Mediterranean area and are used for human food. These fruits and especially the acetonic extract have been shown to possess biological activities, such as anti-cancer properties. AIMS & METHODS: We aim to investigate the effects of the acetonic extract of Feijoa sellowiana fruits on the viability, proliferation, brush border membrane enzyme activities and membrane lipid peroxidation of the human intestinal epithelial cells. Caco-2 cells were seeded into a 6-wells multiwells plate and cultured with appropriate medium. At confluence, cells were starvated for 24h and then exposed to the acetonic extract (500 ug/mL), for 24h. Lactase and sucrase activity, cell proliferation and viability were measured with the modified Dahlqvist method, bromodeoxyuridine incorporation assay and MTT vitality test, respectively. To test membrane lipid peroxidation we used the malondialdehyde (MDA) assay; for this purpose, cells were pre-treated with H2O2 (1 mM) for 2h, with H2O2for 2h and then the acetonic extract for 24h or with the acetonic extract for 2h and then H2O2 for 24h, respectively. Cells with medium alone were used as control. Data are expressed as mean±SD of 8 single experiments. RESULTS: Compared to control conditions, the acetonic extract significantly increased lactase activity (+7.1±1.0 fold increase vs control, p

Published
2012

79. Effect of enteroglial-derived S100B protein on proliferation and responses in human peripheral and mucosal immune cells

Author

Cirillo C, D’Aiuto E, Mango A, De Palma R, SARNELLI, GIOVANNI, TURCO, FABIO, CUOMO, ROSARIO, Cirillo, C, Sarnelli, Giovanni, D’Aiuto, E, Mango, A, Turco, Fabio, De Palma, R, and Cuomo, Rosario

Subjects
immune cells, enteroglial-derived S100B protein
Abstract

Background and aim: Emerging evidence suggests that glial cells in the gut participate to the local immune response triggered by a variety of insults. In humans, during gut inflammation, over-expression of glial-derived S100B protein amplifies nitric oxide mucosal production via receptor for advanced glycation endproducts (RAGE) interaction. Whether S100B is directly affecting the responses of peripheral and mucosal immune cells is still unknown. We aimed to investigate the ability of S100B protein in mediating human immune cells’ proliferation and responses. Material and methods: Mucosal immune cells (MIC) were isolated from rectal mucosal biopsies of 15 control subjects (mean age 53; 6 male and 9 female) with Medimachine system and then characterized by Flow cytometry technique. In the same subjects, peripheral blood mononuclear cells (PBMC) were isolated. Both MIC and PBMC were stimulated with exogenous S100B protein (0.05-5μM), in the presence of anti-RAGE neutralizing antibody (1:10000-1:1000, dil v/v), to evaluate cell proliferation (by methylthiazolydiphenyl-tetrazolium bromide conversion assay, after 72h) and responses [by measuring nitrite level, inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) expression, each after 24h]. Results: In PBMC, S100B exposure induced a significant and concentrationdependent cell proliferation (S100B 5μM: +73% vs basal; p

Published
2010

80. Effect of enteroglial-derived S100B protein on human peripheral and mucosal immune cells’ functions

Author

Cirillo C, D’Aiuto E, Mango A, De Palma R, SARNELLI, GIOVANNI, TURCO, FABIO, CUOMO, ROSARIO, Cirillo, C, Sarnelli, Giovanni, D’Aiuto, E, Mango, A, Turco, Fabio, De Palma, R, and Cuomo, Rosario

Subjects
immune cells, enteroglial-derived S100B protein
Abstract

Background and Aim: Emerging evidence suggests that glial cells in the gut participate to the local immune response triggered by a variety of insults. In humans, during gut inflammation, over-expression of glial-derived S100B protein amplifies nitric oxide mucosal production via receptor for advanced glycation endproducts (RAGE) interaction. Whether S100B is directly affecting the responses of peripheral and mucosal immune cells is still unknown. We aimed to investigate the ability of S100B protein in mediating human immune cells' proliferation and responses. Material and Methods: Mucosal immune cells (MIC) were isolated from rectal mucosal biopsies of 15 control subjects (mean age 53; 6 male and 9 female) with Medimachine system and then characterized by Flow cytometry technique. In the same subjects, peripheral blood mononuclear cells (PBMC) were isolated. Both MIC and PBMC were stimulated with exogenous S100B protein (0.05-5μM), in the presence of anti-RAGE neutralizing antibody (1:10000-1:1000, dil v/v), to evaluate cell proliferation (by methylthiazolydiphenyl- tetrazolium bromide conversion assay, after 72h) and responses [by measuring nitrite level, inducibile nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF- α) expression, each after 24h]. Results: In PBMC, S100B exposure induced a significant and concentration-dependent cell proliferation (S100B 5μM: +73% vs basal; p

Published
2010

81. Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype

Author

Liñán-Rico, Andromeda, primary, Turco, Fabio, additional, Ochoa-Cortes, Fernando, additional, Harzman, Alan, additional, Needleman, Bradley J., additional, Arsenescu, Razvan, additional, Abdel-Rasoul, Mahmoud, additional, Fadda, Paolo, additional, Grants, Iveta, additional, Whitaker, Emmett, additional, Cuomo, Rosario, additional, and Christofi, Fievos L., additional

Published
2016
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83. Sa1682 Mechanosensory Signaling in Human Enteric Glial Cells

Author

Ochoa-Cortes, Fernando, primary, Rico, Andromeda Linan, additional, Zuleta-Alarcon, Alix, additional, Zhou, Min, additional, Whitaker, Emmett, additional, Grants, Iveta, additional, Mutafova-Yambolieva, Violeta N., additional, Durnin, Leonie, additional, Needleman, Bradley J., additional, Harzman, Alan, additional, Cuomo, Rosario, additional, Turco, Fabio, additional, and Christofi, Fievos L., additional

Published
2016
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85. Sa1683 Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for Intestinal Infections, Motility and IBD

Author

Rico, Andromeda Linan, primary, Turco, Fabio, additional, Ochoa-Cortes, Fernando, additional, Harzman, Alan, additional, Arsenescu, Razvan, additional, Abdel-Rasoul, Mahmoud, additional, Fadda, Paolo, additional, Grants, Iveta, additional, Cuomo, Rosario, additional, and Christofi, Fievos L., additional

Published
2016
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86. Enteric Glial Cells

Author

Ochoa-Cortes, Fernando, primary, Turco, Fabio, additional, Linan-Rico, Andromeda, additional, Soghomonyan, Suren, additional, Whitaker, Emmett, additional, Wehner, Sven, additional, Cuomo, Rosario, additional, and Christofi, Fievos L., additional

Published
2016
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87. The Bitter Taste Receptor Agonist Quinine Reduces Calorie Intake and Increases the Postprandial Release of Cholecystokinin in Healthy Subjects

Author

Andreozzi, Paolo, primary, Sarnelli, Giovanni, additional, Pesce, Marcella, additional, Zito, Francesco P, additional, Alessandro, Alessandra D, additional, Verlezza, Viviana, additional, Palumbo, Ilaria, additional, Turco, Fabio, additional, Esposito, Katherine, additional, and Cuomo, Rosario, additional

Published
2015
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88. 63 Gliomodulation of Neuronal and Motor Behavior in the Human GI Tract

Author

Rico, Andromeda Linan, primary, Grants, Iveta, additional, Needleman, Bradley J., additional, Williams, Kent C., additional, Soghomonyan, Suren, additional, Turco, Fabio, additional, Cuomo, Rosario, additional, Grider, John R., additional, Kendig, Derek M., additional, Murthy, K.S., additional, Harzman, Alan, additional, Ochoa-Cortes, Fernando, additional, and Christofi, Fievos L., additional

Published
2015
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89. 383 Modulation of Ca2+ Waves in Human Enteric Glial Cells

Author

Rico, Andromeda Linan, primary, Turco, Fabio, additional, Soghomonyan, Suren, additional, Grants, Iveta, additional, Enneking, Josh, additional, Tso, Daniel R., additional, Needleman, Bradley J., additional, Harzman, Alan, additional, Cuomo, Rosario, additional, Ochoa-Cortes, Fernando, additional, and Christofi, Fievos L., additional

Published
2015
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96. Acetonic Extract from the Feijoa sellowiana Berg. Fruit Exerts Antioxidant Properties and Modulates Disaccharidases Activities in Human Intestinal Epithelial Cells.

Author

Turco, Fabio, Palumbo, Ilaria, Andreozzi, Paolo, Sarnelli, Giovanni, De Ruberto, Francesca, Esposito, Giuseppe, Basile, Adriana, and Cuomo, Rosario

Abstract

Feijoa sellowiana fruit has been shown to possess various biological activities, such as anti-bacterial and anti-cancer properties, in a variety of cellular models, but its activity on human intestinal epithelial cells has never been tested. The purpose of this study was to investigate the effects of the acetonic extract of F. sellowiana fruits on the viability, membrane peroxidation, disaccharidases activities and proliferation of in vitro models of human intestinal epithelial cells. To obtain this goal, Caco-2 and HT-29 cells were exposed to the acetonic extract for 24 h. Cell proliferation, viability, lactase and sucrase-isomaltase activity and H2 O2 -induced membrane lipid peroxidation were tested. We found that, compared to control conditions, the acetonic extract significantly increased lactase and sucrase-isomaltase activity in Caco-2, but not HT-29, cells, decreased proliferation, had no effects on viability and restored lipid peroxidation in both cell models. This study suggests that the acetonic extract improves lactase and sucrase-isomaltase activity, inhibits cell proliferation, have no cytotoxic effects and prevent lipid peroxidation of intestinal epithelial cells. These effects may be exploited in case of disaccharidases deficit and also as an adjuvant treatment of diseases related to oxidative stress. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2016
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99. Bacterial stimuli activate nitric oxide colonic mucosal production in diverticular disease. Protective effects of L. casei DG® (Lactobacillus paracaseiCNCM I-1572)

Author

Turco, Fabio, Andreozzi, Paolo, Palumbo, Ilaria, Zito, Francesco Paolo, Cargiolli, Martina, Fiore, Walter, Gennarelli, Nicola, De Palma, Giovanni Domenico, Sarnelli, Giovanni, and Cuomo, Rosario

Abstract

Micro-inflammation and changes in gut microbiota may play a role in the pathogenesis of diverticular disease (DD). The objective of this article is to evaluate the expression of nitric oxide (NO)-related mediators and S100B in colonic mucosa of patients with DD in an ex vivo model of bacterial infection. Intestinal biopsies obtained from patients with diverticulosis, symptomatic uncomplicated diverticular disease (SUDD) and SUDD with previous acute diverticulitis (SUDD+AD) were stimulated with the probiotic L. caseiDG® (LCDG) and/or the pathogen enteroinvasive Escherichia coli(EIEC). S100B, NO release and iNOS expression were then evaluated. Basal iNOS expression was significantly increased in SUDD and SUDD+AD patients. Basal NO expression was significantly increased in SUDD+AD. No differences in S100B release were found. In all groups, iNOS expression was significantly increased by EIEC and reduced by LCDG. In all groups, except for SUDD+AD, EIEC significantly increased NO release, whereas no increase was observed when LCDG was added to biopsies. EIEC did not induce significant changes in S100B release. Colonic mucosa of patients with DD is characterized by a different reactivity toward pathogenic stimuli. LCDG plays a role in counteracting the pro-inflammatory effects exerted by EIEC, suggesting a beneficial role of this probiotic in DD.

Published
2017
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