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52. Multidimensional Gaussian sums arising from distribution of Birkhoff sums in zero entropy dynamical systems

Author

Bernardo, M., Courbage, M., and Truong, T. T.

Subjects
Nonlinear Sciences - Chaotic Dynamics, Mathematical Physics, Mathematics - Dynamical Systems
Abstract

A duality formula, of the Hardy and Littlewood type for multidimensional Gaussian sums, is proved in order to estimate the asymptotic long time behavior of distribution of Birkhoff sums $S_n$ of a sequence generated by a skew product dynamical system on the $\mathbb{T}^2$ torus, with zero Lyapounov exponents. The sequence, taking the values $\pm 1$, is pairwise independent (but not independent) ergodic sequence with infinite range dependence. The model corresponds to the motion of a particle on an infinite cylinder, hopping backward and forward along its axis, with a transversal acceleration parameter $\alpha$. We show that when the parameter $\alpha /\pi$ is rational then all the moments of the normalized sums $E((S_n/\sqrt{n})^k)$, but the second, are unbounded with respect to n, while for irrational $\alpha /\pi$, with bounded continuous fraction representation, all these moments are finite and bounded with respect to n., Comment: To be published in J. Phys.A

Published
2004
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53. Quantum Hall-like effect on strips due to geometry

Author

Dandoloff, R. and Truong, T. T.

Subjects
Mathematical Physics
Abstract

In this Letter we present an exact calculation of the effective potential which appears on a helicoidal strip. This potential leads to the appearance of lcalized states at a distance \xi_0 from the central axis. The twist \omega of the strip plays the role of a magnetic field and is responsable for the appearance of these localized states and an effective transverse electric field thus this is reminiscent of the quantum Hall effect. At very low temperatures the twisted configuration of the strip may be stalilized by the electronic states., Comment: 3 pages

Published
2004
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54. Evidence of Gene-Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

Author

Nickels, S, Truong, T, Hein, R, Stevens, K, Buck, K, Behrens, S, Eilber, U, Schmidt, M, Häberle, L, Vrieling, A, Gaudet, M, Figueroa, J, Schoof, N, Spurdle, AB, Rudolph, A, Fasching, PA, Hopper, JL, Makalic, E, Schmidt, DF, Southey, MC, Beckmann, MW, Ekici, AB, Fletcher, O, Gibson, L, dos Santos Silva, I, Peto, J, Humphreys, MK, Wang, J, Cordina-Duverger, E, Menegaux, F, Nordestgaard, BG, Bojesen, SE, Lanng, C, Anton-Culver, H, Ziogas, A, Bernstein, L, Clarke, CA, Brenner, H, Müller, H, Arndt, V, Stegmaier, C, Brauch, H, Brüning, T, Harth, V, Mannermaa, A, Kataja, V, Kosma, VM, Hartikainen, JM, Lambrechts, D, Smeets, D, Neven, P, Paridaens, R, Flesch-Janys, D, Obi, N, Wang-Gohrke, S, Couch, FJ, Olson, JE, Vachon, CM, Giles, GG, Severi, G, Baglietto, L, Offit, K, John, EM, Miron, A, Andrulis, IL, Knight, JA, Glendon, G, Mulligan, AM, Chanock, SJ, Lissowska, J, Liu, J, Cox, A, Cramp, H, Connley, D, Balasubramanian, S, Dunning, AM, Shah, M, Trentham-Dietz, A, Newcomb, P, Titus, L, Egan, K, Cahoon, EK, and Rajaraman, P

Abstract

Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study to assess gene-environment interaction for risk of breast cancer. Data from 24 studies of the Breast Cancer Association Consortium were pooled. Using up to 34,793 invasive breast cancers and 41,099 controls, we examined whether the relative risks associated with 23 single nucleotide polymorphisms were modified by 10 established environmental risk factors (age at menarche, parity, breastfeeding, body mass index, height, oral contraceptive use, menopausal hormone therapy use, alcohol consumption, cigarette smoking, physical activity) in women of European ancestry. We used logistic regression models stratified by study and adjusted for age and performed likelihood ratio tests to assess gene-environment interactions. All statistical tests were two-sided. We replicated previously reported potential interactions between LSP1-rs3817198 and parity (Pinteraction= 2.4×10-6) and between CASP8-rs17468277 and alcohol consumption (Pinteraction= 3.1×10-4). Overall, the per-allele odds ratio (95% confidence interval) for LSP1-rs3817198 was 1.08 (1.01-1.16) in nulliparous women and ranged from 1.03 (0.96-1.10) in parous women with one birth to 1.26 (1.16-1.37) in women with at least four births. For CASP8-rs17468277, the per-allele OR was 0.91 (0.85-0.98) in those with an alcohol intake of

Published
2013

55. Behaviour of three charged particles on a plane under perpendicular magnetic field

Author

Ralko, A. and Truong, T. T.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We consider the problem of three identical charged particles on a plane under a perpendicular magnetic field and interacting through Coulomb repulsion. This problem is treated within Taut's framework, in the limit of vanishing center of mass vector $\vec{R} \to \vec{0}$, which corresponds to the strong magnetic field limit, occuring for example in the Fractional Quantum Hall Effect. Using the solutions of the biconfluent Heun equation, we compute the eigenstates and show that there is two sets of solutions. The first one corresponds to a system of three independent anyons which have their angular momenta fixed by the value of the magnetic field and specified by a dimensionless parameter $C \simeq \frac{l_B}{l_0}$, the ratio of $l_B$, the magnetic length, over $l_0$, the Bohr radius. This anyonic character, consistent with quantum mechanics of identical particles in two dimensions, is induced by competing physical forces. The second one corresponds to the case of the Landau problem when $C \to 0$. Finally we compare these states with the quantum Hall states and find that the Laughlin wave functions are special cases of our solutions under certains conditions., Comment: 15 pages, 3 figures, Accepeted in JPA

Published
2002
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56. Heun Functions and the energy spectrum of a charged particle on a sphere under magnetic field and Coulomb force

Author

Ralko, A. and Truong, T. T.

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We study the competitive action of magnetic field, Coulomb repulsion and space curvature on the motion of a charged particle. The three types of interaction are characterized by three basic lengths: l_{B} the magnetic length, l_{0} the Bohr radius and R the radius of the sphere. The energy spectrum of the particle is found by solving a Schr\"odinger equation of the Heun type, using the technique of continued fractions. It displays a rich set of functioning regimes where ratios \frac{R}{l_{B}} and \frac{R}{l_{0}} take definite values., Comment: 12 pages, 5 figures, accepted to JOPA, november 2002

Published
2002
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57. On exact singular wave functions for identical planar charged particles in uniform perpendicular magnetic field

Author

Ralko, A. and Truong, T. T.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We discuss the occurence and properties of exact singular anyonic wave functions describing stationary states of two identical charged particles moving on a plane and under the influence of a perpendicular uniform magnetic field., Comment: 4 pages, 7 figures, accepted in Eur. Phys. J. B

Published
2002

58. Estimation of the incubation period of COVID-19 in Vietnam.

Author

Long V Bui, Ha T Nguyen, Hagai Levine, Ha N Nguyen, Thu-Anh Nguyen, Thuy P Nguyen, Truong T Nguyen, Toan T T Do, Ngoc T Pham, and My Hanh Bui

Subjects
Medicine, Science
Abstract

ObjectiveTo estimate the incubation period of Vietnamese confirmed COVID-19 cases.MethodsOnly confirmed COVID-19 cases who are Vietnamese and locally infected with available data on date of symptom onset and clearly defined window of possible SARS-CoV-2 exposure were included. We used three parametric forms with Hamiltonian Monte Carlo method for Bayesian Inference to estimate incubation period for Vietnamese COVID-19 cases. Leave-one-out Information Criterion was used to assess the performance of three models.ResultsA total of 19 cases identified from 23 Jan 2020 to 13 April 2020 was included in our analysis. Average incubation periods estimated using different distribution model ranged from 6.0 days to 6.4 days with the Weibull distribution demonstrated the best fit to the data. The estimated mean of incubation period using Weibull distribution model was 6.4 days (95% credible interval (CrI): 4.89-8.5), standard deviation (SD) was 3.05 (95%CrI 3.05-5.30), median was 5.6, ranges from 1.35 to 13.04 days (2.5th to 97.5th percentiles). Extreme estimation of incubation periods is within 14 days from possible infection.ConclusionThis analysis provides evidence for an average incubation period for COVID-19 of approximately 6.4 days. Our findings support existing guidelines for 14 days of quarantine of persons potentially exposed to SARS-CoV-2. Although for extreme cases, the quarantine period should be extended up to three weeks.

Published
2020
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63. Diamond alpha differentiability of interval-valued functions and its applicability to interval differential equations on time scales.

Author

Truong, T., Schneider, B., and Nguyen, L.

Subjects
*DIFFERENTIAL equations, *ORDINARY differential equations, *DERIVATIVES (Mathematics), *DIAMONDS, *DIFFERENCE equations
Abstract

Modelling phenomena with interval differential equations (IDEs) is an effective way to consider the uncertainties that are unavoidable when collecting data. Similarly to the theory of ordinary differential equations, IDEs have been parallelly investigated with the interval difference equations from the beginning. These two branches can be regarded as one when unifying continuous and discrete solution domains. A conspicuous advantage when merging these areas is that the proof of several analogous properties in both theories need not be repeated. The paper provides a common and efficient tool for studying IDEs not only with continuous or discrete solution domains but also with more general ones. We propose the diamond-α derivative for interval-valued functions (IVFs) on time scales with respect to the generalized Hukuhara difference. Differently from most of the studies on the derivatives of functions on time scales, using the language of epsilon-delta, the novel concept is naturally studied according to the limit of IVFs on time scales as in classical mathematics. A particular class of IDEs on time scales is then considered with respect to the diamond-α derivative. Numerical problems are elaborated to illustrate the necessity and efficiency of the latter. [ABSTRACT FROM AUTHOR]

Published
2024
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64. Equivalence Between Vector Meson Dominance and Unitarised Chiral Perturbation Theory

Author

Dung, L. V. and Truong, T. N.

Subjects
High Energy Physics - Phenomenology
Abstract

It is explicitly shown that either the approximate solution of the integral equation for the inverse of the pion form factor, or the result of the Pad\'e approximant method of resumming the one loop Chiral Perturbation Theory (CPTH) are equivalent to the standard vector meson dominance (VMD) models, using the vector meson coupling to two pseudoscalars given by the KSRF relation. Inconsistencies between the one loop CPTH and its unitarised version (or the VMD model) are pointed out. The situation is better for the CPTH calculation of the scalar form factor and the related S-wave $\pi \pi$ scattering. The branching ratios of $\tau \to \pi^+ \pi^0 \nu$, $\tau \to K \pi \nu$, $\tau \to K^+ \eta \nu$ and $\tau \to K^+ \bar{K^0} \nu$ using only two inputs as the $\rho $ and $K^*$ masses, or the two corresponding rms radii, agree with the experimental data. Using the same number of parameters, the corresponding one loop CPTH calculation cannot explain the $\tau$ data., Comment: 41 pages, LaTeX+epsfig, 5 figures

Published
1996

65. On the Jastrow Wave Function for N-Particles on a Plane

Author

Azhari, A. and Truong, T. T.

Subjects
Condensed Matter
Abstract

The possibility of describing quantum mechanical particles on a plane by a Jastrow wave function is studied. We obtain the condition under which the particles interact through pair potentials. It is found that if the interparticle forces depend only on distance, then only the attractive harmonic pair potential is consistent with the Jastrow ansatz. We discuss some connections with wave functions encountered in the quantized Hall effect., Comment: 10 pages LaTeX, Phys. Lett. A to appear

Published
1996
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67. Quantum Group Approach to a soluble vertex model with generalized ice-rule

Author

Ciré, L. Sow and Truong, T. T.

Subjects
High Energy Physics - Theory
Abstract

Using the representation of the quantum group $SL_q$(2) by the Weyl ope\-ra\-tors of the canonical commutation relations in quantum mechanics, we construct and solve a new vertex model on a square lattice. Random variables on horizontal bonds are Ising variables, and those on the vertical bonds take half positive integer values. The vertices is subjected to a genera\-li\-zed form of the so-called ``ice-rule'', its property are studied in details and its free energy calculated with the method of quantum inverse scattering. Remarkably in analogy with the usual six-vertex model, there exists a ``Free-Fermion'' limit with a novel rich operator structure. The existing algebraic structure suggests a possible connection with a lattice neutral plasma of charges, via the Fermion-Boson correspondence., Comment: LaTeX files. 19 pages. Figures included using LaTeX format. Uses uufiles

Published
1995
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68. On the Sutherland's Integrability Condition for Two-Dimensional N-Particle Systems

Author

Azhari, A. and Truong, T. T.

Subjects
High Energy Physics - Theory
Abstract

Following Sutherland's work on one-dimensional integrable systems we formulate and study its two-dimensional version. Physically it expresses the absence of true 3-body forces among an assembly of N particles leaving exclusively effective 2-body interactions. This criterion may be a suitable candidate for an integrability condition., Comment: 13 pages,uses LATeX2e and epsf. File prepared using the uufiles package

Published
1995

69. Study of the Strongly Interacting Higgs Physics Model with Heavy Fermions

Author

Dung, L. V., Jikia, G., Roiesnel, C., and Truong, T. N.

Subjects
High Energy Physics - Phenomenology
Abstract

We study the effect of a possible fourth heavy generation of fermions on the Higgs sector of the standard model. We show, from the violation of elastic unitarity, that the scale of strong interactions is well below 1 TeV even with a Higgs mass as low as 500 GeV provided the fourth generation fermion mass is equal or larger than the Higgs mass. The diagonal Pade approximant method is then used to unitarize the partial wave amplitudes. It is found that, for the fourth generation fermion masses which are comparable to or larger than the Higgs mass, the Landau ghosts in the I=0 and I=2 channels of the reconstructed amplitudes move too close to the physical region to be accepted., Comment: 14 pages, LaTeX+epsfig, 2 figures, uuencoded

Published
1995
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70. $\pi \pi$ Scattering and Pion Form Factors

Author

Beldjoudi, L. and Truong, T. N

Subjects
High Energy Physics - Phenomenology
Abstract

The S and P wave $\pi \pi$ phase shifts are recalculated in terms of two phenomenological parameters using the one loop CPTh and the elastic unitarity condition. Using these phase shifts, the vector and scalar form factors are calculated and shown to be in a good agreement with experimental data. It is found that the simpler and more phenomenological approach, where the left hand cut contributions to the partial wave amplitude are neglected, yields approximately the same result., Comment: 8 pages, Tex, 4 postscript figures appended at the end. CPTH-A292.0294

Published
1994

71. Higgs Boson Interference in $\gamma \gamma \rightarrow W^+W^-$

Author

Morris, D. A., Truong, T. N., and Zappala, D.

Subjects
High Energy Physics - Phenomenology
Abstract

We study interference effects between resonant and nonresonant amplitudes for the $\gamma \gamma \rightarrow W^+ W^-$ process at a backscattered photon-photon collider. We show that a Higgs boson with $M_H$ > 200 GeV is manifest as a resonant dip in the $W^+W^-$ invariant mass spectrum and we investigate its statistical significance., Comment: 8 pages (LaTeX) + 5 PostScript figures in accompanying file (uuencoded), figures also available by fax upon request to reyes@uclaph.bitnet, UCLA/TEP/93/35

Published
1993
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72. Corner transfer matrix of generalised free Fermion vertex systems

Author

Eckle, H. -P. and Truong, T. T.

Subjects
Condensed Matter
Abstract

The Hamiltonian limit of the corner transfer matrix (CTM) of a generalised free Fermion vertex system of finite size leads to a quantum spin Hamiltonian of the particular form: \[ {\cal H}_N=-\sum_{n=1}^{N-1}\left\{ n\left( \sigma_n^x\sigma_{n+1}^x +\lambda\sigma_n^y\sigma_{n+1}^y +h(\sigma_n^z+\sigma_{n+1}^z) \right)\right\} \] Diagonalisation may be achieved for all pairs of parameters $(\lambda,h)$ with the use of some new elliptic polynomials which extend the class of special polynomials known so far in the context of CTM., Comment: (No changes of text, replaced LaTeX file fits better to US legal letter) 29 pages, LaTeX, HPETTT-CTM-93-02

Published
1993

73. Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma

Author

Holcombe, RF, Marsh, JL, Waterman, ML, Lin, F, Milovanovic, T, and Truong, T

Subjects
Colo-Rectal Cancer, Cancer, Genetics, Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Biomarkers, Tumor, Cell Differentiation, Cell Transformation, Neoplastic, Colon, Colonic Neoplasms, Frizzled Receptors, Gene Expression, Humans, In Situ Hybridization, Ligands, Neoplasm Proteins, Proto-Oncogene Proteins, RNA, Messenger, RNA, Neoplasm, Receptors, G-Protein-Coupled, Receptors, Neurotransmitter, Signal Transduction, Tumor Cells, Cultured, Wnt Proteins, Wnt2 Protein, Zebrafish Proteins, Clinical Sciences, Medical Microbiology, Pathology
Abstract

AimsSignalling through the Wnt pathway is integrally associated with colon carcinogenesis. Although activating mutations in the genes for adenomatous polyposis coli (APC) and beta-catenin are clearly associated with colon cancer, less is understood about the role of the upstream secreted ligands (Wnts) and their receptors (frizzled, Fz) in this process. In other systems, increased Wnt signalling has been shown to alter the expression of components of this pathway. This study was designed to test the hypothesis that colon cancer is characterised by aberrant expression of specific Wnt genes and Fz receptors.MethodsThe expression of Wnt genes was assessed by in situ, antisense RNA hybridisation in paraffin wax embedded samples of normal and malignant human colon tissues with probes specific for the individual Wnt genes. The expression of Fz1 and Fz2 was determined by immunoperoxidase based antibody staining on human tissues.ResultsChanges in the expression of some ligands and receptors were seen in colon cancer. For example, Wnt2 mRNA was detected in colon cancer but was undetectable in normal colonic mucosa. Differential expression of Wnt5a in normal mucosa was also noted, with increased expression at the base of the crypts compared with the luminal villi and slightly increased expression in colon cancer. Wnt7a exhibited minimal expression in both normal and malignant colon tissues, whereas other Wnt ligands including Wnts 1, 4, 5b, 6, 7b, and 10b were expressed equally and strongly in both normal and malignant colon tissues. In defining cellular responses and phenotype, the type and distribution of Fz receptors may be as important as the pattern of Wnt ligand expression. No expression of Fz receptor 1 and 2 was seen in normal colonic mucosa and in well differentiated tumours. However, poorly differentiated tumours exhibited a high degree of Fz receptor expression, especially at the margin of cellular invasion.ConclusionsThese data indicate that the expression of members of the Wnt signal transduction pathway, distinct from APC and beta-catenin, is integrally associated with the process of colon carcinogenesis. Wnt2, and possibly Wnt5a, may be involved in the progression from normal mucosa to cancer and the expression of Fz1/2 receptors may be involved in processes associated with tumour invasion. Altered expression of these Wnts and Fz receptors may prove useful as prognostic or diagnostic markers for patients with colon cancer.

Published
2002

75. FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Author

Figlioli, G, Billaud, A, Ahearn, TU, Antonenkova, NN, Becher, H, Beckmann, MW, Behrens, S, Benitez, J, Bermisheva, M, Blok, MJ, Bogdanova, N, Bonanni, B, Burwinkel, B, Camp, NJ, Campbell, A, Castelao, JE, Cessna, MH, Chanock, SJ, Czene, K, Devilee, P, Doerk, T, Engel, C, Eriksson, M, Fasching, PA, Figueroa, JD, Gabrielson, M, Gago-Dominguez, M, Garcia-Closas, M, Gonzalez-Neira, A, Grassmann, F, Guenel, P, Gundert, M, Hadjisavvas, A, Hahnen, E, Hall, P, Hamann, U, Harrington, PA, He, W, Hillemanns, P, Hollestelle, A, Hooning, MJ, Hoppe, R, Howell, A, Humphreys, K, Jager, A, Jakubowska, A, Khusnutdinova, EK, Ko, Y-D, Kristensen, VN, Lindblom, A, Lissowska, J, Lubinski, J, Mannermaa, A, Manoukian, S, Margolin, S, Mavroudis, D, Newman, WG, Obi, N, Panayiotidis, M, Rashid, MU, Rhenius, V, Rookus, MA, Saloustros, E, Sawyer, EJ, Schmutzler, RK, Shah, M, Sironen, R, Southey, MC, Suvanto, M, Tollenaar, RAEM, Tomlinson, I, Truong, T, van der Kolk, LE, van Veen, EM, Wappenschmidt, B, Yang, XR, Bolla, MK, Dennis, J, Dunning, AM, Easton, DF, Lush, M, Michailidou, K, Pharoah, PDP, Wang, Q, Adank, MA, Schmidt, MK, Andrulis, IL, Chang-Claude, J, Nevanlinna, H, Chenevix-Trench, G, Evans, DG, Milne, RL, Radice, P, Peterlongo, P, Figlioli, G, Billaud, A, Ahearn, TU, Antonenkova, NN, Becher, H, Beckmann, MW, Behrens, S, Benitez, J, Bermisheva, M, Blok, MJ, Bogdanova, N, Bonanni, B, Burwinkel, B, Camp, NJ, Campbell, A, Castelao, JE, Cessna, MH, Chanock, SJ, Czene, K, Devilee, P, Doerk, T, Engel, C, Eriksson, M, Fasching, PA, Figueroa, JD, Gabrielson, M, Gago-Dominguez, M, Garcia-Closas, M, Gonzalez-Neira, A, Grassmann, F, Guenel, P, Gundert, M, Hadjisavvas, A, Hahnen, E, Hall, P, Hamann, U, Harrington, PA, He, W, Hillemanns, P, Hollestelle, A, Hooning, MJ, Hoppe, R, Howell, A, Humphreys, K, Jager, A, Jakubowska, A, Khusnutdinova, EK, Ko, Y-D, Kristensen, VN, Lindblom, A, Lissowska, J, Lubinski, J, Mannermaa, A, Manoukian, S, Margolin, S, Mavroudis, D, Newman, WG, Obi, N, Panayiotidis, M, Rashid, MU, Rhenius, V, Rookus, MA, Saloustros, E, Sawyer, EJ, Schmutzler, RK, Shah, M, Sironen, R, Southey, MC, Suvanto, M, Tollenaar, RAEM, Tomlinson, I, Truong, T, van der Kolk, LE, van Veen, EM, Wappenschmidt, B, Yang, XR, Bolla, MK, Dennis, J, Dunning, AM, Easton, DF, Lush, M, Michailidou, K, Pharoah, PDP, Wang, Q, Adank, MA, Schmidt, MK, Andrulis, IL, Chang-Claude, J, Nevanlinna, H, Chenevix-Trench, G, Evans, DG, Milne, RL, Radice, P, and Peterlongo, P

Abstract

Evidence from literature, including the BRIDGES study, indicates that germline protein truncating variants (PTVs) in FANCM confer moderately increased risk of ER-negative and triple-negative breast cancer (TNBC), especially for women with a family history of the disease. Association between FANCM missense variants (MVs) and breast cancer risk has been postulated. In this study, we further used the BRIDGES study to test 689 FANCM MVs for association with breast cancer risk, overall and in ER-negative and TNBC subtypes, in 39,885 cases (7566 selected for family history) and 35,271 controls of European ancestry. Sixteen common MVs were tested individually; the remaining rare 673 MVs were tested by burden analyses considering their position and pathogenicity score. We also conducted a meta-analysis of our results and those from published studies. We did not find evidence for association for any of the 16 variants individually tested. The rare MVs were significantly associated with increased risk of ER-negative breast cancer by burden analysis comparing familial cases to controls (OR = 1.48; 95% CI 1.07-2.04; P = 0.017). Higher ORs were found for the subgroup of MVs located in functional domains or predicted to be pathogenic. The meta-analysis indicated that FANCM MVs overall are associated with breast cancer risk (OR = 1.22; 95% CI 1.08-1.38; P = 0.002). Our results support the definition from previous analyses of FANCM as a moderate-risk breast cancer gene and provide evidence that FANCM MVs could be low/moderate risk factors for ER-negative and TNBC subtypes. Further genetic and functional analyses are necessary to clarify better the increased risks due to FANCM MVs.

Published
2023

76. Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers

Author

Sugier, P.E., Lucotte, E.A., Domenighetti, C., Law, M.H., Iles, M.M., Brown, K., Amos, C., McKay, J.D., Hung, R.J., Karimi, M., Bacq-Daian, D., Boland-Augé, A., Olaso, R., Deleuze, J.F., Lesueur, F., Ostroumova, E., Kesminiene, A., Vathaire, F. de, Guénel, P., Sreelatha, A.A.K., Schulte, C., Grover, S., May, P., Bobbili, D.R., Radivojkov-Blagojevic, M., Lichtner, P., Singleton, A.B., Hernandez, D.G., Edsall, C., Mellick, G.D., Zimprich, A., Pirker, W., Rogaeva, E., Lang, A.E., Koks, S., Taba, P., Lesage, S., Brice, A., Corvol, J.C., Chartier-Harlin, M.C., Mutez, E., Brockmann, K., Deutschländer, A.B., Hadjigeorgiou, G.M., Dardiotis, E., Stefanis, L., Simitsi, A.M., Valente, E.M., Petrucci, S., Straniero, L., Zecchinelli, A., Pezzoli, G., Brighina, L., Ferrarese, C., Annesi, G., Quattrone, A., Gagliardi, M., Matsuo, H., Nakayama, A., Hattori, N., Nishioka, K., Chung, S.J., Kim, Y. J., Kolber, P., Warrenburg, B.P.C. van de, Bloem, B.R., Aasly, J., Toft, M., Pihlstrøm, L., Guedes, L.C., Ferreira, J.J., Bardien, S., Carr, J., Tolosa, E., Ezquerra, M., Pastor, P., Diez-Fairen, M., Wirdefeldt, K., Pedersen, N., Ran, C., Belin, A.C., Puschmann, A., Rödström, E.Y., Clarke, C.E., Morrison, K.E., Tan, M., Krainc, D., Burbulla, L.F., Farrer, M.J., Kruger, R., Gasser, T., Sharma, M., Truong, T., Elbaz, A., Sugier, P.E., Lucotte, E.A., Domenighetti, C., Law, M.H., Iles, M.M., Brown, K., Amos, C., McKay, J.D., Hung, R.J., Karimi, M., Bacq-Daian, D., Boland-Augé, A., Olaso, R., Deleuze, J.F., Lesueur, F., Ostroumova, E., Kesminiene, A., Vathaire, F. de, Guénel, P., Sreelatha, A.A.K., Schulte, C., Grover, S., May, P., Bobbili, D.R., Radivojkov-Blagojevic, M., Lichtner, P., Singleton, A.B., Hernandez, D.G., Edsall, C., Mellick, G.D., Zimprich, A., Pirker, W., Rogaeva, E., Lang, A.E., Koks, S., Taba, P., Lesage, S., Brice, A., Corvol, J.C., Chartier-Harlin, M.C., Mutez, E., Brockmann, K., Deutschländer, A.B., Hadjigeorgiou, G.M., Dardiotis, E., Stefanis, L., Simitsi, A.M., Valente, E.M., Petrucci, S., Straniero, L., Zecchinelli, A., Pezzoli, G., Brighina, L., Ferrarese, C., Annesi, G., Quattrone, A., Gagliardi, M., Matsuo, H., Nakayama, A., Hattori, N., Nishioka, K., Chung, S.J., Kim, Y. J., Kolber, P., Warrenburg, B.P.C. van de, Bloem, B.R., Aasly, J., Toft, M., Pihlstrøm, L., Guedes, L.C., Ferreira, J.J., Bardien, S., Carr, J., Tolosa, E., Ezquerra, M., Pastor, P., Diez-Fairen, M., Wirdefeldt, K., Pedersen, N., Ran, C., Belin, A.C., Puschmann, A., Rödström, E.Y., Clarke, C.E., Morrison, K.E., Tan, M., Krainc, D., Burbulla, L.F., Farrer, M.J., Kruger, R., Gasser, T., Sharma, M., Truong, T., and Elbaz, A.

Abstract

Item does not contain fulltext, BACKGROUND: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. OBJECTIVE: We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors. METHODS: We used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses. RESULTS: We confirmed a previously reported positive genetic correlation of PD with melanoma (G(corr) = 0.16 [0.04; 0.28]) and reported an additional significant positive correlation of PD with prostate cancer (G(corr) = 0.11 [0.03; 0.19]). There was a significant inverse association between the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89 [0.84; 0.94]). Conversely, the PRS of PD was positively associated with breast cancer (OR = 1.08 [1.06; 1.10]) and inversely associated with ovarian cancer (OR = 0.95 [0.91; 0.99]). The association between PD and ovarian cancer was mostly driv

Published
2023

77. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.

Author

Wang, A, Shen, J, Rodriguez, AA, Saunders, EJ, Chen, F, Janivara, R, Darst, BF, Sheng, X, Xu, Y, Chou, AJ, Benlloch, S, Dadaev, T, Brook, MN, Plym, A, Sahimi, A, Hoffman, TJ, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Laisk, T, Figuerêdo, J, Muir, K, Ito, S, Liu, X, Biobank Japan Project, Uchio, Y, Kubo, M, Kamatani, Y, Lophatananon, A, Wan, P, Andrews, C, Lori, A, Choudhury, PP, Schleutker, J, Tammela, TLJ, Sipeky, C, Auvinen, A, Giles, GG, Southey, MC, MacInnis, RJ, Cybulski, C, Wokolorczyk, D, Lubinski, J, Rentsch, CT, Cho, K, Mcmahon, BH, Neal, DE, Donovan, JL, Hamdy, FC, Martin, RM, Nordestgaard, BG, Nielsen, SF, Weischer, M, Bojesen, SE, Røder, A, Stroomberg, HV, Batra, J, Chambers, S, Horvath, L, Clements, JA, Tilly, W, Risbridger, GP, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordstrom, T, Pashayan, N, Dunning, AM, Ghoussaini, M, Travis, RC, Key, TJ, Riboli, E, Park, JY, Sellers, TA, Lin, H-Y, Albanes, D, Weinstein, S, Cook, MB, Mucci, LA, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, DJ, Penney, KL, Turman, C, Tangen, CM, Goodman, PJ, Thompson, IM, Hamilton, RJ, Fleshner, NE, Finelli, A, Parent, M-É, Stanford, JL, Ostrander, EA, Koutros, S, Beane Freeman, LE, Stampfer, M, Wolk, A, Håkansson, N, Andriole, GL, Hoover, RN, Machiela, MJ, Sørensen, KD, Borre, M, Blot, WJ, Zheng, W, Yeboah, ED, Mensah, JE, Lu, Y-J, Zhang, H-W, Feng, N, Mao, X, Wu, Y, Zhao, S-C, Sun, Z, Thibodeau, SN, McDonnell, SK, Schaid, DJ, West, CML, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, AS, Drake, BF, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, YA, John, EM, Grindedal, EM, Maehle, L, Khaw, K-T, Ingles, SA, Stern, MC, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, BS, Kerns, SL, Ostrer, H, Teixeira, MR, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, JT, Butler, EN, Mohler, JL, Taylor, JA, Kogevinas, M, Dierssen-Sotos, T, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, CC, Huff, CD, Pilie, P, Yu, Y, Bohlender, RJ, Gu, J, Strom, SS, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, RJ, Brenner, H, Chen, X, Holleczek, B, Schöttker, B, Klein, EA, Hsing, AW, Kittles, RA, Murphy, AB, Logothetis, CJ, Kim, J, Neuhausen, SL, Steele, L, Ding, YC, Isaacs, WB, Nemesure, B, Hennis, AJM, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S-H, Newcomb, LF, Lin, DW, Fowke, JH, Neslund-Dudas, CM, Rybicki, BA, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Abraham, A, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, JE, Martinez, ME, Larkin, S, Townsend, PA, Aukim-Hastie, C, Bush, WS, Aldrich, MC, Crawford, DC, Srivastava, S, Cullen, J, Petrovics, G, Casey, G, Wang, Y, Tettey, Y, Lachance, J, Tang, W, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Yamoah, K, Govindasami, K, Chokkalingam, AP, Keaton, JM, Hellwege, JN, Clark, PE, Jalloh, M, Gueye, SM, Niang, L, Ogunbiyi, O, Shittu, O, Amodu, O, Adebiyi, AO, Aisuodionoe-Shadrach, OI, Ajibola, HO, Jamda, MA, Oluwole, OP, Nwegbu, M, Adusei, B, Mante, S, Darkwa-Abrahams, A, Diop, H, Gundell, SM, Roobol, MJ, Jenster, G, van Schaik, RHN, Hu, JJ, Sanderson, M, Kachuri, L, Varma, R, McKean-Cowdin, R, Torres, M, Preuss, MH, Loos, RJF, Zawistowski, M, Zöllner, S, Lu, Z, Van Den Eeden, SK, Easton, DF, Ambs, S, Edwards, TL, Mägi, R, Rebbeck, TR, Fritsche, L, Chanock, SJ, Berndt, SI, Wiklund, F, Nakagawa, H, Witte, JS, Gaziano, JM, Justice, AC, Mancuso, N, Terao, C, Eeles, RA, Kote-Jarai, Z, Madduri, RK, Conti, DV, Haiman, CA, Wang, A, Shen, J, Rodriguez, AA, Saunders, EJ, Chen, F, Janivara, R, Darst, BF, Sheng, X, Xu, Y, Chou, AJ, Benlloch, S, Dadaev, T, Brook, MN, Plym, A, Sahimi, A, Hoffman, TJ, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Laisk, T, Figuerêdo, J, Muir, K, Ito, S, Liu, X, Biobank Japan Project, Uchio, Y, Kubo, M, Kamatani, Y, Lophatananon, A, Wan, P, Andrews, C, Lori, A, Choudhury, PP, Schleutker, J, Tammela, TLJ, Sipeky, C, Auvinen, A, Giles, GG, Southey, MC, MacInnis, RJ, Cybulski, C, Wokolorczyk, D, Lubinski, J, Rentsch, CT, Cho, K, Mcmahon, BH, Neal, DE, Donovan, JL, Hamdy, FC, Martin, RM, Nordestgaard, BG, Nielsen, SF, Weischer, M, Bojesen, SE, Røder, A, Stroomberg, HV, Batra, J, Chambers, S, Horvath, L, Clements, JA, Tilly, W, Risbridger, GP, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordstrom, T, Pashayan, N, Dunning, AM, Ghoussaini, M, Travis, RC, Key, TJ, Riboli, E, Park, JY, Sellers, TA, Lin, H-Y, Albanes, D, Weinstein, S, Cook, MB, Mucci, LA, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, DJ, Penney, KL, Turman, C, Tangen, CM, Goodman, PJ, Thompson, IM, Hamilton, RJ, Fleshner, NE, Finelli, A, Parent, M-É, Stanford, JL, Ostrander, EA, Koutros, S, Beane Freeman, LE, Stampfer, M, Wolk, A, Håkansson, N, Andriole, GL, Hoover, RN, Machiela, MJ, Sørensen, KD, Borre, M, Blot, WJ, Zheng, W, Yeboah, ED, Mensah, JE, Lu, Y-J, Zhang, H-W, Feng, N, Mao, X, Wu, Y, Zhao, S-C, Sun, Z, Thibodeau, SN, McDonnell, SK, Schaid, DJ, West, CML, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, AS, Drake, BF, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, YA, John, EM, Grindedal, EM, Maehle, L, Khaw, K-T, Ingles, SA, Stern, MC, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, BS, Kerns, SL, Ostrer, H, Teixeira, MR, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, JT, Butler, EN, Mohler, JL, Taylor, JA, Kogevinas, M, Dierssen-Sotos, T, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, CC, Huff, CD, Pilie, P, Yu, Y, Bohlender, RJ, Gu, J, Strom, SS, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, RJ, Brenner, H, Chen, X, Holleczek, B, Schöttker, B, Klein, EA, Hsing, AW, Kittles, RA, Murphy, AB, Logothetis, CJ, Kim, J, Neuhausen, SL, Steele, L, Ding, YC, Isaacs, WB, Nemesure, B, Hennis, AJM, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S-H, Newcomb, LF, Lin, DW, Fowke, JH, Neslund-Dudas, CM, Rybicki, BA, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Abraham, A, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, JE, Martinez, ME, Larkin, S, Townsend, PA, Aukim-Hastie, C, Bush, WS, Aldrich, MC, Crawford, DC, Srivastava, S, Cullen, J, Petrovics, G, Casey, G, Wang, Y, Tettey, Y, Lachance, J, Tang, W, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Yamoah, K, Govindasami, K, Chokkalingam, AP, Keaton, JM, Hellwege, JN, Clark, PE, Jalloh, M, Gueye, SM, Niang, L, Ogunbiyi, O, Shittu, O, Amodu, O, Adebiyi, AO, Aisuodionoe-Shadrach, OI, Ajibola, HO, Jamda, MA, Oluwole, OP, Nwegbu, M, Adusei, B, Mante, S, Darkwa-Abrahams, A, Diop, H, Gundell, SM, Roobol, MJ, Jenster, G, van Schaik, RHN, Hu, JJ, Sanderson, M, Kachuri, L, Varma, R, McKean-Cowdin, R, Torres, M, Preuss, MH, Loos, RJF, Zawistowski, M, Zöllner, S, Lu, Z, Van Den Eeden, SK, Easton, DF, Ambs, S, Edwards, TL, Mägi, R, Rebbeck, TR, Fritsche, L, Chanock, SJ, Berndt, SI, Wiklund, F, Nakagawa, H, Witte, JS, Gaziano, JM, Justice, AC, Mancuso, N, Terao, C, Eeles, RA, Kote-Jarai, Z, Madduri, RK, Conti, DV, and Haiman, CA

Abstract

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.

Published
2023

80. Cigarette Smoking and Endometrial Cancer Risk:Observational and Mendelian Randomization Analyses

Author

Dimou, N, Omiyale, W, Biessy, C, Viallon, V, Kaaks, R, O'Mara, TA, Aglago, EK, Ardanaz, E, Bergmann, MM, Bondonno, NP, Braaten, T, Colorado-Yohar, SM, Crous-Bou, M, Dahm, CC, Fortner, RT, Gram, IT, Harlid, S, Heath, AK, Idahl, A, Kvaskoff, M, Nøst, TH, Overvad, K, Palli, D, Perez-Cornago, A, Sacerdote, C, Sánchez, M-J, Schulze, MB, Severi, G, Simeon, V, Tagliabue, G, Tjønneland, A, Truong, T, Tumino, R, Johansson, M, Weiderpass, E, Murphy, N, Gunter, MJ, Lacey, B, Allen, NE, Dossus, L, Dimou, N., Omiyale, W., Biessy, C., Viallon, V., Kaaks, R., O'Mara, T. A., Aglago, E. K., Ardanaz, E., Bergmann, M. M., Bondonno, N. P., Braaten, T., Colorado-Yohar, S. M., Crous-Bou, M., Dahm, C. C., Fortner, R. T., Gram, I. T., Harlid, S., Heath, A. K., Idahl, A., Kvaskoff, M., Nost, T. H., Overvad, K., Palli, D., Perez-Cornago, A., Sacerdote, C., Sanchez, M. -J., Schulze, M. B., Severi, G., Simeon, V., Tagliabue, G., Tjonneland, A., Truong, T., Tumino, R., Johansson, M., Weiderpass, E., Murphy, N., Gunter, M. J., Lacey, B., Allen, N. E., and Dossus, L.

Subjects
Epidemiology, ESTROGENS, Polymorphism, Single Nucleotide, BREAST, Article, Cigarette Smoking, Risk Factors, GENETIC-VARIANTS, REGRESSION, Humans, Genetic Predisposition to Disease, Prospective Studies, 11 Medical and Health Sciences, INDEX, Cancer och onkologi, IDENTIFICATION, WOMEN, Public Health, Global Health, Social Medicine and Epidemiology, Mendelian Randomization Analysis, Endometrial Neoplasms, OVERLAP, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Oncology, Cancer and Oncology, OBESITY, Female, SEX-HORMONES, Genome-Wide Association Study
Abstract

Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In twosampleMR analyses, genetic variants robustly associated with lifetime amount of smoking (n ¼ 126 variants) and ever having smoked regularly (n ¼ 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91–1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. Impact: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk., World Health Organization, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, NIHR Imperial Biomedical Research Centre (BRC), Danish Cancer Society, Ligue Contre le Cancer (France) Institut Gustave Roussy (France) MutuelleGenerale de l'Education Nationale (France), Institut National de la Sante et de la Recherche Medicale (Inserm), Deutsche Krebshilfe German Cancer Research Center (DKFZ) (Germany) German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany) Federal Ministry of Education & Research (BMBF), Fondazione AIRC per la ricerca sul cancro Compagnia di San Paolo Consiglio Nazionale delle Ricerche (CNR), Netherlands Government Netherlands Government, World Cancer Research Fund International (WCRF), Netherlands Government, Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII) (Spain), Junta de Andalucia, Principality of Asturias Regional Government of Basque Country (Spain) Regional Government of Murcia (Spain) Regional Government of Navarra (Spain) Catalan Institute of Oncology - ICO (Spain), Swedish Cancer Society Swedish Research Council County Council of Skane (Sweden) County Council of Vasterbotten (Sweden), Cancer Research UK 14136 C8221/A29017, UK Research & Innovation (UKRI), Medical Research Council UK (MRC) 1000143 MR/M012190/1 MR/N003284/1 MC-UU_12015/1 MC_UU_00006/ 1, Cancer Research UK C864/A14136 C18281/A29019

Published
2022

83. A Comparative Study on Polyphenol, Flavonoid Content, Antioxidant and AntiInflammatory Capacity of Different Solvent Extract from Portulaca oleracea in Carrageenan-Induced Paw Edema in Mice.

Author

Thao, Truong T. P., Tu, Phan T. C., and Men, Tran T

Subjects
COMPARATIVE studies, POLYPHENOLS, FLAVONOIDS, ANTIOXIDANTS, SOLVENT extraction, PORTULACA oleracea
Abstract

Portulaca oleracea L., belonging to the Portulacaceae family, is a succulent annual plant, that has been used as vegetables and folk medicine in many Asian countries. There is no systematic and comprehensive research on the comparison of phytochemical quantification and biological activities from various extracts of this plant. This study examined the total polyphenol and flavonoid content of various Portulaca oleracea extracts and assessed their antioxidant and antiinflammatory properties. Comparing four extracts (methanol, aqueous, ethyl acetate, n-hexane) from P. oleracea, methanolic extract (ME) showed the greatest total polyphenol (60.52±1.88, mg GAE/g DW) and flavonoid content (44.78±1.17 mg QE/g DW). Thus, across all activities examined, ME had the strongest in vitro antioxidant (IC50=43.52 μg/mL for DPPH, IC50=9.71 μg/mL for FRAP), and anti-inflammatory effects (80% protein denaturation and 74.81% protection of HRBC membrane). Remarkably, after treatment of ME for 5 h, ME has significantly reduced paw volume (0.098 mL) and thickness (0.62 mm) on carrageenan-induced inflammation (hind paw edema model), compared to the inflamed model (0.19 mL and 1.52 mm). Moreover, ME helps protect the inflamed site in mice based on its ability to reduce malondialdehyde (MDA) and increase glutathione (GSH). The applications of ME in the treatment of inflammatory illnesses and oxidative damage are pharmacologically supported by our results. Also, 60 minutes after ingestion of ME, it dramatically raised the plasma levels of polyphenols and flavonoids as well as the antiradical capacity in healthy mice. Our results showed that ME consumption can support in vivo diet-related health advantages. [ABSTRACT FROM AUTHOR]

Published
2023
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85. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries: results from the EPIC cohort study

Author

Castro-Espin, C, Bonet, C, Crous-Bou, M, Nadal-Zaragoza, N, Tjønneland, A, Mellemkjær, L, Hajji-Louati, M, Truong, T, Katzke, V, Le Cornet, C, Schulze, MB, Jannasch, F, Masala, G, Sieri, S, Panico, S, Di Girolamo, C, Skeie, G, Borch, KB, Olsen, KS, Sánchez, M-J, Amiano, P, Chirlaque, M-D, Guevara, M, Sund, M, Bodén, S, Gunter, MJ, Gonzalez-Gil, EM, Weiderpass, E, Aguilera-Buenosvinos, I, Tsilidis, KK, Heath, AK, Aune, D, Dossus, L, and Agudo, A

Subjects
Näringslära, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Nutrition and Dietetics, Breast cancer, Cancer survivors, Mediterranean diet, Public Health, Global Health, Social Medicine and Epidemiology, Dietary patterns, Prospective studies
Abstract

BACKGROUND: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. METHODS: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0-5), medium (score 6-8), and high (score 9-16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. RESULTS: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01-1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84-1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87-0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72-0.91). CONCLUSIONS: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of metastatic breast cancer. Well-designed dietary interventions are needed to confirm these findings and define specific dietary recommendations.

Published
2023

89. The Words of the Human Locomotion

Author

Laumond, J. -P., Arechavaleta, G., Truong, T. -V. -A., Hicheur, H., Pham, Q. -C., Berthoz, A., Siciliano, Bruno, editor, Khatib, Oussama, editor, Groen, Frans, editor, Kaneko, Makoto, editor, and Nakamura, Yoshihiko, editor

Published
2011
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90. LBA6 Neoadjvuant versus adjuvant pembrolizumab for resected stage III-IV melanoma (SWOG S1801)

Author

Patel, S., primary, Othus, M., additional, Prieto, V., additional, Lowe, M., additional, Buchbinder, E., additional, Chen, Y., additional, Hyngstrom, J., additional, Lao, C.D., additional, Truong, T-G., additional, Chandra, S., additional, Kendra, K., additional, Devoe, C., additional, Hedge, A., additional, Mangla, A., additional, Sharon, E., additional, Korde, L., additional, Moon, J., additional, Sondak, V., additional, and Ribas, A., additional

Published
2022
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99. Water security assessment framework for deltas of the transboundary river basins.

Author

Truong, T. H., Nguyen, L. T. T., Nguyen, D. D., Pham, T., Vu, T. M., Nguyen, P. H., and Nguyen, Q. T.

Subjects
WATER security, WATERSHEDS, TRANSBOUNDARY waters, INTERNATIONAL cooperation, WATER supply, ENVIRONMENTAL protection
Abstract

BACKGROUND AND OBJECTIVES: Water security for food production in the deltas of international river basins has become the top concern of the basin countries. Numerous efforts were made to develop frameworks for the assessment of water security at different scales. However, no framework could be directly applied to the deltas of the transboundary basins because they have not fully addressed the characteristics of the deltas. This study aims to develop a comprehensive framework for the assessment of water security for the international river basin deltas and applied it to the Vietnamese Mekong Delta. METHODS: The water security assessment framework was developed on the basis of the concept of water security defined by the United Nations Water following the "Driving forces-Pressure-State-Impact-Response" approach. The developed framework is then used to evaluate the water security conditions for 22 subregions of the Mekong Delta. FINDINGS: The proposed water security assessment framework comprises the following six dimensions: water resources, domestic water supply, water for economic development, water-related disasters, ecological and environmental protection, and water governance, which contain 21 indicators and 5 sub-indicators. The results of applying this framework to the Mekong Delta showed that the overall water security conditions in most subregions in 2018 were only at the medium level. The degree of water security in flood season is higher than that in the dry season. The main reasons that lead to the medium-level water security of the region have been identified, including high dependence on external water resources (more than 90%) and transboundary water cooperation between the basin countries and rather low water productivity in economic sectors. The study suggests that improvement in transboundary water cooperation and water productivity would help enhance future water security in the Mekong Delta. CONCLUSION: Assessment of the water security for the deltas of the transboundary river basins requires a comprehensive assessment framework. The framework developed in this study was successfully applied to the case of the Vietnamese Mekong Delta. The proposed framework will help policymakers of the Mekong riparian countries to monitor the impact of the basin development plans and policies on water security conditions jointly and determine appropriate solutions to enhance water security for the basin. [ABSTRACT FROM AUTHOR]

Published
2023
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