61 results on '"Truls Hauge"'
Search Results
52. Clinical Experience with a Nitinol Self-Expanding Colonic Stent - Data from the WallFlex-eR Colonic International Registry
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Søren Meisner, Alessandro Repici, Marc Giovannini, Ferran González-Huix, Purushothaman Premchand, H. Ptok, Truls Hauge, Bruce M. Fox, Eric Bartoli, Angelo Paulo Ferrari, Mohandas K. Mallath, Dimitrios Xinopoulos, Jo Vandervoort, AntóNio José Marques, P. A. Goldberg, Michael Hünerbein, and Paul Kortan
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medicine.medical_specialty ,business.industry ,Gastroenterology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Colonic stent - Published
- 2008
53. Mucosal bacterial growth in the upper gastrointestinal tract in alcoholics (heavy drinkers)
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Dan Danielsson, Jesper Persson, and Truls Hauge
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Adult ,Male ,medicine.medical_specialty ,Abdominal pain ,Duodenum ,Biopsy ,Gastroenterology ,Duodenitis ,Internal medicine ,Gastroscopy ,medicine ,Humans ,Intestinal Mucosa ,Aged ,Sweden ,biology ,medicine.diagnostic_test ,Bacteria ,business.industry ,Stomach ,Helicobacter pylori ,Middle Aged ,biology.organism_classification ,medicine.disease ,Diarrhea ,Alcoholism ,medicine.anatomical_structure ,Gastric acid ,Female ,Gastritis ,medicine.symptom ,business ,Hydrogen breath test ,Digestive System - Abstract
Mucosal adherent bacterial flora in chronic alcoholics was studied and compared to a control group referred for upper endoscopy, mainly for dyspepsia.22 alcoholics, admitted to hospital for detoxification, were examined using upper gastrointestinal endoscopy. Gastric and duodenal biopsies were taken for tissue pathology, quantitative and qualitative anaerobic and aerobic bacteriological culture and for culture of Helicobacter pylori (antral biopsies). 12 nonalcoholics, admitted for upper endoscopy mainly for dyspepsia, were chosen as a control group. Seven of these had used gastric acid inhibitors.Gastrointestinal symptoms were common among alcoholics: 20/22 (90%) had diarrhea, nausea and/or abdominal pain. There were signs of gastritis by endoscopy in 64% of the alcoholics and in 58% of the controls. Tissue pathology, however, showed active chronic antral gastritis in 27% of the alcoholics and in 42% of the controls. H. pylori were isolated in 7/22 of the alcoholics and in 4/12 of the controls, which corresponds to the mean prevalence for these age groups in Sweden. Significantly more bacteria, dominated by gram-positive aerobic cocci, were present in the gastric biopsies of alcoholics than in those of controls (mean of 2.9 x 10(6)/g material versus 4.4 x 10(5), p0.05). There were 2.6 times more bacteria in the duodenal biopsies of alcoholics than in those of the controls (p0.05, NS). Bacterial overgrowth (defined as2 x 10(3) organisms/g material) was found in the stomach in 20/22 (90%) alcoholics and in 6/12 (50%) controls (p0.01).Alcoholics have an increased frequency of bacterial overgrowth in the upper gastrointestinal tract. This may contribute to the common gastrointestinal symptoms.
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- 1997
54. Iatrogenic esophago-tracheal fistula: Challenges in diagnosis and management
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Truls Hauge, Øyvind Haugen Lie, Øistein Hovde, Per Arthur Johansson, Bjørn Hofstad, Egil Johnson, and Øystein Stubhaug
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Male ,medicine.medical_specialty ,Fistula ,Iatrogenic Disease ,Case Report ,Esophageal Fistula ,Bronchoscopy ,Swallowing ,Predictive Value of Tests ,Humans ,Medicine ,Esophagus ,Drug Packaging ,Aged ,Tracheal fistula ,Tracheal Diseases ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Respiratory Tract Fistula ,General Medicine ,Foreign Bodies ,medicine.disease ,Deglutition ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Predictive value of tests ,Stents ,Esophagoscopy ,Tomography, X-Ray Computed ,business - Abstract
Esophageo-tracheal fistula is a rare condition, and in most cases such fistulas are caused by malignant disease or emergency endotracheal intubation. A case where a wrapped tablet produced a fistula between the esophagus and trachea is described. The patient is a male born in 1938 who swallowed a tablet without unwrapping it. The patient was treated with self-expanding metal stents (SEMS), but closure of the fistula was not achieved. Different examinations and treatment options are discussed. Surgical treatment for this condition has demonstrated considerable mortality and morbidity. In some cases closure of the fistula can be achieved by use of SEMS. Although we advise treatment of such cases with SEMS, in some cases treatment with stents will prove troublesome and the risk/benefit analysis will have to be reevaluated.
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- 2013
55. Distribution of alkaline sphingomyelinase activity in human beings and animals. Tissue and species differences
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Truls Hauge, Erik Hertervig, Aijaz Farooqi, Å Nilsson, R-D. Duan, Berit Sternby, Jan Lillienau, and Lena Nyberg
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Adult ,medicine.medical_specialty ,Brush border ,Physiology ,Biology ,Urine ,Guinea pig ,Intestinal mucosa ,Species Specificity ,Internal medicine ,medicine ,Animals ,Bile ,Humans ,Mammals ,Stomach ,Gastroenterology ,Infant ,Hydrogen-Ion Concentration ,Small intestine ,medicine.anatomical_structure ,Endocrinology ,Milk ,Sphingomyelin Phosphodiesterase ,Biochemistry ,Pancreatic juice ,Duodenum ,Digestion ,Digestive System - Abstract
The alkaline sphingomyelinase (SMase) was first found in rat intestinal brush border. The important roles of this enzyme in digestion of sphingomyelin and in mucosal cell proliferation have been suggested. In the present work, the distribution of the alkaline SMase in the tissues of human beings and animals have been studied. By assaying the enzyme activity in human biopsy samples, we found that the alkaline SMase activity was absent in the stomach, increased in the duodenum, present at high levels in the small intestine, and slightly declined in the colon and rectum. High activities were found similarly in the intestinal contents of the healthy adults and infants. The activities were also found in the intestinal mucosa of rats, normal and germ-free mice, and hamsters with the same distribution pattern as in humans, but not in the intestinal mucosa of guinea pigs. Apart from the intestinal tract, a SMase activity preferring alkaline pH was identified in human and guinea pig bile, but not in the bile of rat, pig, sheep, and cow. No activity was found in either pancreatic tissue or pancreatic juice in all species tested, and none was detected in human urine and milk. In conclusion, alkaline SMase exists predominantly in the digestive system with considerable tissue and species differences.
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- 1996
56. P-0085 Locally Advanced/Metastatic Cholangiocarcinoma Treated with Stent, Gemcitabine/Capecitabine Plus-Minus Photodynamic Therapy (Temoporfin) – Preliminary Results From a Norwegian Phase II Trial
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Truls Hauge, Zbigniew Konopski, Trond Buanes, Anders Drolsum, Trond Warloe, Petra Weber Hauge, I Franco-Lie, Catrine Johansen, Lars Aabakken, and Ellen Viktil
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medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Stent ,Hematology ,Neutropenia ,medicine.disease ,Gemcitabine ,Surgery ,law.invention ,Capecitabine ,Oncology ,Randomized controlled trial ,law ,medicine ,Progression-free survival ,business ,Liver abscess ,medicine.drug - Abstract
Introduction Chemotherapy has been shown to improve survival in patients with locally advanced and metastatic cholangiocarcinoma (CC). Similar data have been reported with photodynamic therapy (PDT) in combination with stent drainage. A combination of these treatment modalities might improve outcomes further, but such data are still lacking. Therefore we have performed the first randomized trial on the combination of temoporfin/PDT, stent and chemotherapy versus stent and chemotherapy only. Methods Randomized phase II trial with feasibility and toxicity as endpoints. Preliminary data on progression free survival will also be reported. Inclusion criteria were unresectable, treatment naive patients with CC confirmed by histology or cytology, need for biliary stent, bilirubin level Results Twenty patients with locally advanced and metastatic disease were included, ten patients in each arm. Eight men and twelve women, age 35-75 years. Two patients in arm A did not receive chemotherapy (ECOG>2, infection) and two patients in arm B (thrombocytopenia, study withdrawal). No serious, procedure-related complication was seen. Three cases of cholangitis were observed in both group A and B during the first 30 days. Within the next two months three additional patients in each group had cholangitis, grade 3-4. No liver abscess was observed within 30 days. Within three months, liver abscess was found in two patients, group A. Neutropenia grade 3 was observed in 2 patients in both arms, no neutropenic infection. Preliminary data on progression free survival (three still without progression, one just started) were mean 212 days in group A compared to 162 days in group B. Data on QoL will be reported. Conclusion The total number of cholangitis was equal in both groups, two abscesses were seen only in group A, more than one month after PDT. No other serious complication related to PDT was seen. Preliminary, progression free survival seems to be prolonged in group A. Depending on the final data a larger study should be considered.
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- 2012
57. Photodynamic therapy with temoporfin in combination with gemcitabine/capecitabine in biliary tract cancer: Feasibility and safety in a randomized phase II trial
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Zbigniew Konopski, Anders Drolsum, Lars Aabakken, Petra Weber Hauge, Truls Hauge, Ellen Viktil, I Franco-Lie, Cathrine K Johansen, Trond Warloe, and Trond Buanes
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Oncology ,Cancer Research ,medicine.medical_specialty ,Poor prognosis ,Biliary tract cancer ,business.industry ,medicine.medical_treatment ,Photodynamic therapy ,Gemcitabine ,Capecitabine ,Temoporfin ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Medicine ,business ,Surgical treatment ,medicine.drug - Abstract
e14637 Background: Patients whocannot be offered curative surgical treatment for biliary tract cancer (BTC) have a poor prognosis. Photodynamic therapy (PDT) has been shown to improve survival and quality of life in patients with unresectable BTC. A combination of treatment modalities might improve survival further, but such data are still lacking. Therefore we have performed the first randomized trial on the combination of temoporfin/PDT and chemotherapy. Here we report data on the feasibility and safety. Methods: Randomized phase II trial, planned to include 20 patients with time to progression as primary endpoint, feasibility and toxicity as secondary endpoints. Inclusion criteria were unresectable BTC confirmed by histology or cytology, need for biliary stent, bilirubin level < 50 mmol/L and no previous cancer disease. The treatment arms were: A: Stent, temoporfin / PDT followed by gemcitabin / capecitabin (GemCap). B: Stent, GemCap. Only one initial PDT treatment was given. Results: Twenty patients with locally advanced and metastatic disease were included, 10 patients in each arm. Two patients in arm B did not receive any treatment (thrombocytopenia, study withdrawal) and two patients in arm A did not receive chemotherapy (ECOG>2, infection). PDT was feasible in all 10 patients without any acute procedure-related complication. During the first 30 days, two cases of cholangitis in arm A and three in arm B were observed. Cutaneous erythema (grade 1-2) was observed after PDT in two patients. Conclusions: PDT using temoporfin in combination with chemotherapy in BTC was feasible. Restrictions to light exposure were well tolerated. PDT in combination with chemotherapy did not increase the complication rate during the first 30 days follow-up. Three months follow-up data will be available at the time for presentation. Larger prospective trials are warranted to assess the efficacy of this treatment combination.
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- 2012
58. M1007 A Prospective Randomized Double-Blind Placebo-Controlled Multicenter Trial of Glyceryl Nitrate Preventing Post-ERCP Pancreatitis
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Truls Hauge, Margarita Elkjaer, Peter Matzen, Claes Hjalmarsson, Laurent Heyries, K Bakkevold, Mads Hornum, and Camilla Nøjgaard
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Double blind ,medicine.medical_specialty ,Hepatology ,business.industry ,Internal medicine ,Multicenter trial ,Gastroenterology ,medicine ,business ,Placebo ,Post ercp pancreatitis - Published
- 2008
59. ESPAC Satellite Symposium
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E. Papachristov, John P. Neoptolemos, J. Kleeff, C. Dervenis, Truls Hauge, P. Pederzoli, Frank Gansauge, Dan Danielsson, Roger Mountford, Francesco Gambilonghi, K. Link, Argenis Castro, M.W. Büchler, Bengt Jeppsson, Anthony Kawesha, H.G. Beger, A. Gumbs, C. Bassi, Nicholas R. Lemoine, Jesper Persson, D.J. Kerr, Massimo Falconi, Anna-Lena Grahm, José M. Gil-Vernet, James Carmichael, Fermín Mearin, Hans G. Beger, Paolo Gentilini, Margaret D. Finch, Nathan Howes, Peeyush Sharma, D. Birk, Stanislaw Garwacki, Giorgio La Villa, James D. Evans, P. Hermanek, J. Jeekel, Andrea Formentini, H. Beger, David Cunningham, Karl-Heinrich Link, Maria Weichetek, M. Büchler, Sergio Pedrazzoli, Chiara Lazzeri, Claudio Bassi, G. Fortnagel, R. A. Popescu, Justin S. Waters, F. Laçaine, Giacomo Laffi, L. Fernandez-Cruz, H. Friess, Juan-R. Malagelada, Franco Franchi, Wojtek Karlik, Ian O. Ellis, Sabrina Vecchiarino, Paula Ghaneh, Paul Ross, Paolo Pederzoli, J.P. Neoptolemos, Michael Raraty, Robert Sutton, and Åke Andrén-Sandberg
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biology ,Gastroenterology ,Environmental science ,Satellite (biology) ,biology.organism_classification ,Remote sensing - Published
- 1997
60. Subject Index Vol. 58, 1997
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Michael Raraty, Robert Sutton, Åke Andrén-Sandberg, Karl-Heinrich Link, Massimo Falconi, D. Birk, J. Kleeff, Truls Hauge, P. Pederzoli, Claudio Bassi, M.W. Büchler, Anthony Kawesha, Stanislaw Garwacki, Dan Danielsson, Fermín Mearin, Francesco Gambilonghi, F. Laçaine, J. Jeekel, Wojtek Karlik, Chiara Lazzeri, Roger Mountford, H. Beger, Sergio Pedrazzoli, Jesper Persson, Franco Franchi, Hans G. Beger, Argenis Castro, Giacomo Laffi, Ian O. Ellis, Peeyush Sharma, C. Bassi, H.G. Beger, Nicholas R. Lemoine, Maria Weichetek, José M. Gil-Vernet, C. Dervenis, D.J. Kerr, K. Link, E. Papachristov, H. Friess, Frank Gansauge, Sabrina Vecchiarino, A. Gumbs, Paolo Gentilini, J.P. Neoptolemos, Bengt Jeppsson, Nathan Howes, P. Hermanek, Andrea Formentini, Giorgio La Villa, L. Fernandez-Cruz, James Carmichael, Paolo Pederzoli, G. Fortnagel, David Cunningham, Paul Ross, Juan-R. Malagelada, R. A. Popescu, Paula Ghaneh, James D. Evans, M. Büchler, Anna-Lena Grahm, Justin S. Waters, Margaret D. Finch, and John P. Neoptolemos
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Index (economics) ,Statistics ,Gastroenterology ,Subject (documents) ,Mathematics - Published
- 1997
61. Body composition in older acute stroke patients after treatment with individualized, nutritional supplementation while in hospital
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Per Ole Iversen, Truls Hauge, and Lisa Ha
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Male ,medicine.medical_specialty ,Nutritional Supplementation ,Nutritional Status ,lcsh:Geriatrics ,law.invention ,Cohort Studies ,Randomized controlled trial ,Weight loss ,law ,Internal medicine ,medicine ,Humans ,Precision Medicine ,Stroke ,Aged ,Aged, 80 and over ,business.industry ,Nutritional Support ,Body Weight ,Malnutrition ,Age Factors ,Anthropometry ,medicine.disease ,Surgery ,Hospitalization ,lcsh:RC952-954.6 ,Treatment Outcome ,Body Composition ,Female ,medicine.symptom ,Geriatrics and Gerontology ,business ,Bioelectrical impedance analysis ,Body mass index ,Cohort study ,Research Article - Abstract
Background Individualized, nutritional support reduced undernutrition among older stroke patients and improved quality of life in our recent randomized, controlled trial. Weight control thus seems to be important after stroke, and methods for monitoring nutritional status need to be simple and non-invasive. Here we aimed to assess if the nutritional intervention altered body composition in men and women in this study cohort, and also to examine the correlation between the methods for assessing body-, fat- and fat-free mass. Methods Acute stroke patients > 65 years at nutritional risk were randomized to either individualized, nutritional treatment with energy- and protein rich supplementation (intervention, n = 58) or routine, nutritional care (control, n = 66) while in hospital. Body composition was assessed with anthropometry and bioelectrical impedance. The follow-up period was three months. Results During the first week while in hospital, weight loss was smaller in the intervention group compared with the controls (P = 0.013). After three months weight- and fat loss were significant in both men and women. Whereas no significant differences were found in changes in body composition between the male study groups, in the women both weight loss (P = 0.022) and fat loss (P = 0.005) was smaller in the intervention group compared with the controls. A high correlation (r = 0.87) between mid upper arm circumference (MUAC) and body mass index (BMI) was found. Conclusions Individualized nutritional support to older stroke patients in hospital was beneficial for maintaining an adequate body mass and body composition the first week and seemed to have a preventive effect on fat loss among women, but not among men after three months. Measurement of MUAC may be used in the assessment of nutritional status when BMI cannot be obtained. Trial registration This trial is registered with ClinicalTrials.gov, number NCT00163007.
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