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51. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

Author

Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A., Ward, Heather A., Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M., Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H., Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria Dolores, Travier, Noémie, Travis, Ruth C., Sanchez, Maria Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, Vineis, Paolo, Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A., Ward, Heather A., Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M., Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H., Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria Dolores, Travier, Noémie, Travis, Ruth C., Sanchez, Maria Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, and Vineis, Paolo

Published
2016

52. Plasma carotenoids, Vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Infection & Immunity, Bakker, Marije F., Peeters, Petra H M, Klaasen, Veronique M., Bueno-De-Mesquita, H. Bas, Jansen, Eugene H J M, Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, Van Gils, Carla H., Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Infection & Immunity, Bakker, Marije F., Peeters, Petra H M, Klaasen, Veronique M., Bueno-De-Mesquita, H. Bas, Jansen, Eugene H J M, Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, and Van Gils, Carla H.

Published
2016

53. Identifying high-risk individuals for lung cancer screening: Going beyond NLST criteria.

Author

Fu, Marcela, Travier, Noémie, Martín-Sánchez, Juan Carlos, Martínez-Sánchez, Jose M., Vidal, Carmen, Garcia, Montse, and null, null

Subjects
*LUNG cancer, *CANCER diagnosis, *EARLY detection of cancer, *OBSTRUCTIVE lung diseases, *DIAGNOSTIC imaging, *PREDICTION models
Abstract

Background: There are two main types of strategies to identify target population for lung cancer screening: 1) strategies based on age and cumulative smoking criteria, 2) risk prediction models allowing the calculation of an individual risk. The objective of this study was to compare different strategies to identify the proportion of the Spanish population at high risk of developing lung cancer, susceptible to be included in a lung cancer screening programme. Methods: Cross-sectional study. We used the data of the Spanish National Interview Health Survey (ENSE) of 2011–2012 (21,006 individuals) to estimate the proportion of participants at high risk of developing lung cancer. This estimation was performed using the U.S. national lung screening trial (NLST) criteria and a 6-year prediction model (PLCOm2012), both independently and in combination. Results: The prevalence of individuals at high risk of developing lung cancer according to the NLST criteria was 4.9% (7.9% for men, 2.4% for women). Among the 1,034 subjects who met the NLST criteria, 533 (427 men and 106 women) had a 6-year lung cancer risk ≥2.0%. The combination of these two selection strategies showed that 2.5% of the Spanish population had a high risk of developing lung cancer. However, this selection process did not take into account different groups of subjects <75 years old having an individual risk of lung cancer ≥2%, such as heavy smokers <55 years old who were long-time former smokers, and ever-smokers having smoked <30 pack-years with other risk factors. Conclusions: Further research is needed to determine which selection strategy achieves a higher benefit/harm ratio and to assess other prevention strategies for individuals with elevated risk for lung cancer but who do not meet the screening eligibility criteria. [ABSTRACT FROM AUTHOR]

Published
2018
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54. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Author

Roura, Esther, primary, Travier, Noémie, additional, Waterboer, Tim, additional, de Sanjosé, Silvia, additional, Bosch, F. Xavier, additional, Pawlita, Michael, additional, Pala, Valeria, additional, Weiderpass, Elisabete, additional, Margall, Núria, additional, Dillner, Joakim, additional, Gram, Inger T., additional, Tjønneland, Anne, additional, Munk, Christian, additional, Palli, Domenico, additional, Khaw, Kay-Tee, additional, Overvad, Kim, additional, Clavel-Chapelon, Françoise, additional, Mesrine, Sylvie, additional, Fournier, Agnès, additional, Fortner, Renée T., additional, Ose, Jennifer, additional, Steffen, Annika, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Orfanos, Philippos, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Polidoro, Silvia, additional, Mattiello, Amalia, additional, Lund, Eiliv, additional, Peeters, Petra H., additional, Bueno-de-Mesquita, H. B(as)., additional, Quirós, J. Ramón, additional, Sánchez, María-José, additional, Navarro, Carmen, additional, Barricarte, Aurelio, additional, Larrañaga, Nerea, additional, Ekström, Johanna, additional, Lindquist, David, additional, Idahl, Annika, additional, Travis, Ruth C., additional, Merritt, Melissa A., additional, Gunter, Marc J., additional, Rinaldi, Sabina, additional, Tommasino, Massimo, additional, Franceschi, Silvia, additional, Riboli, Elio, additional, and Castellsagué, Xavier, additional

Published
2016
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55. Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Epi Kanker Team A, Kyrø, Cecilie, Zamora-Ros, Raul, Scalbert, Augustin, Tjønneland, Anne, Dossus, Laure, Johansen, Christoffer, Bidstrup, Pernille Envold, Weiderpass, Elisabete, Christensen, Jane, Ward, Heather, Aune, Dagfinn, Riboli, Elio, His, Mathilde, Clavel-Chapelon, Françoise, Baglietto, Laura, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Floegel, Anna, Overvad, Kim, Lasheras, Cristina, Travier, Noémie, Sánchez, Maria José, Amiano, Pilar, Chirlaque, Maria Dolores, Ardanaz, Eva, Khaw, Kay Tee, Wareham, Nick, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Grioni, Sara, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H. B., Peeters, Petra H., van Gils, Carla, Borgquist, Signe, Butt, Salma, Zeleniuch-Jacquotte, Anne, Sund, Malin, Hjartåker, Anette, Skeie, Guri, Olsen, Anja, Romieu, Isabelle, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Epi Kanker Team A, Kyrø, Cecilie, Zamora-Ros, Raul, Scalbert, Augustin, Tjønneland, Anne, Dossus, Laure, Johansen, Christoffer, Bidstrup, Pernille Envold, Weiderpass, Elisabete, Christensen, Jane, Ward, Heather, Aune, Dagfinn, Riboli, Elio, His, Mathilde, Clavel-Chapelon, Françoise, Baglietto, Laura, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Floegel, Anna, Overvad, Kim, Lasheras, Cristina, Travier, Noémie, Sánchez, Maria José, Amiano, Pilar, Chirlaque, Maria Dolores, Ardanaz, Eva, Khaw, Kay Tee, Wareham, Nick, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Grioni, Sara, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H. B., Peeters, Petra H., van Gils, Carla, Borgquist, Signe, Butt, Salma, Zeleniuch-Jacquotte, Anne, Sund, Malin, Hjartåker, Anette, Skeie, Guri, Olsen, Anja, and Romieu, Isabelle

Published
2015

56. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Freisling, Heinz, primary, Pisa, Pedro T., additional, Ferrari, Pietro, additional, Byrnes, Graham, additional, Moskal, Aurelie, additional, Dahm, Christina C., additional, Vergnaud, Anne-Claire, additional, Boutron-Ruault, Marie-Christine, additional, Fagherazzi, Guy, additional, Cadeau, Claire, additional, Kühn, Tilman, additional, Neamat-Allah, Jasmine, additional, Buijsse, Brian, additional, Boeing, Heiner, additional, Halkjær, Jytte, additional, Tjonneland, Anne, additional, Hansen, Camilla P., additional, Quirós, J. Ramón, additional, Travier, Noémie, additional, Molina-Montes, Esther, additional, Amiano, Pilar, additional, Huerta, José M., additional, Barricarte, Aurelio, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas, additional, Key, Tim J., additional, Romaguera, Dora, additional, Lu, Yunxia, additional, Lassale, Camille M., additional, Naska, Androniki, additional, Orfanos, Philippos, additional, Trichopoulou, Antonia, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Berrino, Franco, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, de Magistris, Maria Santucci, additional, Bueno-de-Mesquita, H. Bas, additional, Ocké, Marga C., additional, Sonestedt, Emily, additional, Ericson, Ulrika, additional, Johansson, Mattias, additional, Skeie, Guri, additional, Weiderpass, Elisabete, additional, Braaten, Tonje, additional, Peeters, Petra H. M., additional, and Slimani, Nadia, additional

Published
2015
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57. Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial

Author

Travier, Noémie, primary, Velthuis, Miranda J., additional, Steins Bisschop, Charlotte N., additional, van den Buijs, Bram, additional, Monninkhof, Evelyn M., additional, Backx, Frank, additional, Los, Maartje, additional, Erdkamp, Frans, additional, Bloemendal, Haiko J., additional, Rodenhuis, Carla, additional, de Roos, Marnix A.J., additional, Verhaar, Marlies, additional, ten Bokkel Huinink, Daan, additional, van der Wall, Elsken, additional, Peeters, Petra H.M., additional, and May, Anne M., additional

Published
2015
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59. Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Author

Jakobsen, Marianne U, Dethlefsen, Claus, Due, Karen M, Slimani, Nadia, Chajès, Veronique, May, Anne M, Sørensen, Thorkild I A, Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der A, Daphne L, Bueno-de-Mesquita, H B, Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M, Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H M, Overvad, Kim, Jakobsen, Marianne U, Dethlefsen, Claus, Due, Karen M, Slimani, Nadia, Chajès, Veronique, May, Anne M, Sørensen, Thorkild I A, Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der A, Daphne L, Bueno-de-Mesquita, H B, Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M, Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H M, and Overvad, Kim

Abstract

OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. METHOD: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. RESULTS: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. CONCLUSION: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

Published
2011
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60. Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Author

Jakobsen, Marianne Uhre, Dethlefsen, Claus, Due, Karen Margrete, Slimani, Nadia, Chajès, Veronique, May, Anne M, Sørensen, Thorkild I A, Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der, Daphne L, Bueno-de-Mesquita, H B, Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M, Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H M, Overvad, Kim, Jakobsen, Marianne Uhre, Dethlefsen, Claus, Due, Karen Margrete, Slimani, Nadia, Chajès, Veronique, May, Anne M, Sørensen, Thorkild I A, Halkjær, Jytte, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Zylis, Dimosthenis, Makrygiannis, George, Palli, Domenico, Mattiello, Amalia, Tagliabue, Giovanna, van der, Daphne L, Bueno-de-Mesquita, H B, Rodríguez, Laudina, Travier, Noémie, Molina-Montes, Esther, Huerta, José M, Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfält, Elisabet, Johansson, Ingegerd, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca, Romieu, Isabelle, Riboli, Elio, Peeters, Petra H M, and Overvad, Kim

Abstract

We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers.

Published
2011

61. Obesity, inflammatory markers, and endometrial cancer risk : a prospective case-control study

Author

Dossus, Laure, Rinaldi, Sabina, Becker, Susen, Lukanova, Annekatrin, Tjonneland, Anne, Olsen, Anja, Stegger, Jakob, Overvad, Kim, Chabbert-Buffet, Nathalie, Jimenez-Corona, Aida, Clavel-Chapelon, Francoise, Rohrmann, Sabine, Teucher, Birgit, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Benetou, Vassiliki, Lagiou, Pagona, Palli, Domenico, Berrino, Franco, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Redondo, Maria-Luisa, Travier, Noémie, Sanchez, Maria-Jose, Altzibar, Jone M, Chirlaque, Maria-Dolores, Ardanaz, Eva, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel J B, Onland-Moret, N Charlotte, Peeters, Petra H M, Hallmans, Göran, Lundin, Eva, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi, Key, Tim J, Slimani, Nadia, Hainaut, Pierre, Romaguera, Dora, Norat, Teresa, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rinaldi, Sabina, Becker, Susen, Lukanova, Annekatrin, Tjonneland, Anne, Olsen, Anja, Stegger, Jakob, Overvad, Kim, Chabbert-Buffet, Nathalie, Jimenez-Corona, Aida, Clavel-Chapelon, Francoise, Rohrmann, Sabine, Teucher, Birgit, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Benetou, Vassiliki, Lagiou, Pagona, Palli, Domenico, Berrino, Franco, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Redondo, Maria-Luisa, Travier, Noémie, Sanchez, Maria-Jose, Altzibar, Jone M, Chirlaque, Maria-Dolores, Ardanaz, Eva, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel J B, Onland-Moret, N Charlotte, Peeters, Petra H M, Hallmans, Göran, Lundin, Eva, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi, Key, Tim J, Slimani, Nadia, Hainaut, Pierre, Romaguera, Dora, Norat, Teresa, Riboli, Elio, and Kaaks, Rudolf

Abstract

Obesity, a major risk factor for endometrial cancer, is a low-grade inflammatory state characterized by elevated concentrations of cytokines and acute phase reactants. The current study had two aims: first to investigate the associations of C-reactive protein (CRP), interleukin 6 (IL6), and IL1 receptor antagonist (IL1Ra) with endometrial cancer risk and second to examine to which extent these markers can influence the association between obesity and endometrial cancer. We conducted a case-control study, nested within the European Prospective Investigation into Cancer and Nutrition, which comprised 305 incident cases of endometrial cancer and 574 matched controls. CRP, IL6, and IL1Ra were measured in prospectively collected blood specimens by immunoassays. Data were analyzed using conditional logistic regression. All statistical tests were two-sided, and P values <0.05 were considered statistically significant. We observed a significant increase in risk of endometrial cancer with elevated levels of CRP (odds ratio (OR) for top versus bottom quartile: 1.58, 95% confidence interval (CI): 1.03-2.41, P(trend)=0.02), IL6 (OR for top versus bottom quartile: 1.66, 95% CI: 1.08-2.54, P(trend)=0.008), and IL1Ra (OR for top versus bottom quartile: 1.82, 95% CI: 1.22-2.73, P(trend)=0.004). After adjustment for body mass index (BMI), the estimates were strongly reduced and became non-significant. The association between BMI and endometrial cancer was also substantially attenuated (∼10-20%) after adjustment for inflammatory markers, even when the effects of C-peptide or estrone had already been taken into account. We provided epidemiological evidence that chronic inflammation might mediate the association between obesity and endometrial cancer and that endometrial carcinogenesis could be promoted by an inflammatory milieu.

Published
2010
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62. Menstrual and reproductive factors, exogenous hormone use, and gastric cancer risk in a cohort of women from the European Prospective Investigation Into Cancer and Nutrition

Author

Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, MC, Clavel-Chapelon, F, Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E, Tsilidis, Konstantinos K, Bueno-de-Mesquita, H Bas, Jeurnink, Suzanne M, Numans, ME, Peeters, Petra HM, Lagiou, Pagona, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova-McGregor, Annekatrin, Bergman, Manuela M, Boeing, Heiner, Manjer, Jonas, Lindkvist, Björn, Stenling, Roger, Hallmans, Göran, Dahm, Christina C, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Bakken, Kjersti, Lund, Eiliv, Jenab, Mazda, McCormack, Valerie, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Nesi, Gabriella, Carneiro, Fatima, Riboli, Elio, González, Carlos A, Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, MC, Clavel-Chapelon, F, Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E, Tsilidis, Konstantinos K, Bueno-de-Mesquita, H Bas, Jeurnink, Suzanne M, Numans, ME, Peeters, Petra HM, Lagiou, Pagona, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova-McGregor, Annekatrin, Bergman, Manuela M, Boeing, Heiner, Manjer, Jonas, Lindkvist, Björn, Stenling, Roger, Hallmans, Göran, Dahm, Christina C, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Bakken, Kjersti, Lund, Eiliv, Jenab, Mazda, McCormack, Valerie, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Nesi, Gabriella, Carneiro, Fatima, Riboli, Elio, and González, Carlos A

Abstract

The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95% confidence interval: 0.31, 0.98; P(trend) = 0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women.

Published
2010
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63. Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author

Cust, Anne E, Kaaks, Rudolf, Friedenreich, Christine, Bonnet, Fabrice, Laville, Martine, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Jakobsen, Marianne Uhre, Chajès, Véronique, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Linseisen, Jakob, Lukanova, Annekatrin, Boeing, Heiner, Pischon, Tobias, Trichopoulou, Antonia, Christina, Bamia, Trichopoulos, Dimitrios, Palli, Domenico, Berrino, Franco, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Gram, Inger Torhild, Lund, Eiliv, Quirós, J R, Travier, Noémie, Martínez-García, Carmen, Larrañaga, Nerea, Chirlaque, María-Dolores, Ardanaz, Eva, Berglund, Göran, Lundin, Eva, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel J B, Peeters, Petra H M, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Key, Tim, Ferrari, Pietro, Rinaldi, Sabina, Slimani, Nadia, Riboli, Elio, Cust, Anne E, Kaaks, Rudolf, Friedenreich, Christine, Bonnet, Fabrice, Laville, Martine, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Jakobsen, Marianne Uhre, Chajès, Véronique, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Linseisen, Jakob, Lukanova, Annekatrin, Boeing, Heiner, Pischon, Tobias, Trichopoulou, Antonia, Christina, Bamia, Trichopoulos, Dimitrios, Palli, Domenico, Berrino, Franco, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Gram, Inger Torhild, Lund, Eiliv, Quirós, J R, Travier, Noémie, Martínez-García, Carmen, Larrañaga, Nerea, Chirlaque, María-Dolores, Ardanaz, Eva, Berglund, Göran, Lundin, Eva, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel J B, Peeters, Petra H M, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Key, Tim, Ferrari, Pietro, Rinaldi, Sabina, Slimani, Nadia, and Riboli, Elio

Published
2007

64. Impact of Cigarette Smoking on Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

Author

Agudo, Antonio, primary, Bonet, Catalina, additional, Travier, Noémie, additional, González, Carlos A., additional, Vineis, Paolo, additional, Bueno-de-Mesquita, H. Bas, additional, Trichopoulos, Dimitrios, additional, Boffetta, Paolo, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Kaaks, Rudolf, additional, Lukanova, Annekatrin, additional, Schütze, Madlen, additional, Boeing, Heiner, additional, Tjonneland, Anne, additional, Halkjaer, Jytte, additional, Overvad, Kim, additional, Dahm, Christina C., additional, Quirós, J. Ramon, additional, Sánchez, María-José, additional, Larrañaga, Nerea, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas J., additional, Key, Timothy J., additional, Allen, Naomi E., additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Boshuizen, Hendriek, additional, Büchner, Frederike L., additional, Peeters, Petra H.M., additional, Borgquist, Signe, additional, Almquist, Martin, additional, Hallmans, Göran, additional, Johansson, Ingegerd, additional, Gram, Inger T., additional, Lund, Eiliv, additional, Weiderpass, Elisabete, additional, Romieu, Isabelle, additional, and Riboli, Elio, additional

Published
2012
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65. Prospective Study on Physical Activity and Risk of In Situ Breast Cancer

Author

Steindorf, Karen, primary, Ritte, Rebecca, additional, Tjonneland, Anne, additional, Johnsen, Nina Føns, additional, Overvad, Kim, additional, Østergaard, Jane Nautrup, additional, Clavel-Chapelon, Françoise, additional, Fournier, Agnès, additional, Dossus, Laure, additional, Lukanova, Annekatrin, additional, Chang-Claude, Jenny, additional, Boeing, Heiner, additional, Wientzek, Angelika, additional, Trichopoulou, Antonia, additional, Karapetyan, Tina, additional, Trichopoulos, Dimitrios, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Polidoro, Silvia, additional, Quirós, José Ramón, additional, Travier, Noémie, additional, Sánchez, María-José, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Bueno-de-Mesquita, H. Bas, additional, van Duijnhoven, Fränzel J.B., additional, Monninkhof, Evelyn, additional, May, Anne M., additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Key, Tim J., additional, Travis, Ruth C., additional, Borch, Kristin Benjaminsen, additional, Fedirko, Veronika, additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Wark, Petra A., additional, Norat, Teresa, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional

Published
2012
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66. Combined Impact of Lifestyle Factors on Prospective Change in Body Weight and Waist Circumference in Participants of the EPIC-PANACEA Study

Author

May, Anne M., primary, Romaguera, Dora, additional, Travier, Noémie, additional, Ekelund, Ulf, additional, Bergmann, Manuela M., additional, Kaaks, Rudolf, additional, Teucher, Birgit, additional, Steffen, Annika, additional, Boeing, Heiner, additional, Halkjaer, Jytte, additional, Tjonneland, Anne, additional, Jakobsen, Marianne Uhre, additional, Overvad, Kim, additional, Dartois, Laureen, additional, Fagherazzi, Guy, additional, Boutron-Ruault, Marie-Christine, additional, Quirós, J. Ramón, additional, Agudo, Antonio, additional, Gonzalez, Carlos, additional, Sánchez, María-José, additional, Amiano, Pilar, additional, Huerta, Jose-Maria, additional, Ardanaz, Eva, additional, Wareham, Nicholas J., additional, Crowe, Francesca L., additional, Naska, Androniki, additional, Orfanos, Philippos, additional, Trichopoulou, Antonia, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, H. Bas, additional, Verschuren, Monique, additional, Drake, Isabel, additional, Sonestedt, Emily, additional, Braaten, Tonje, additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Slimani, Nadia, additional, Norat, Teresa, additional, Riboli, Elio, additional, and Peeters, Petra H. M., additional

Published
2012
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67. Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author

Duell, Eric J., primary, Travier, Noémie, additional, Lujan‐Barroso, Leila, additional, Dossus, Laure, additional, Boutron‐Ruault, Marie‐Christine, additional, Clavel‐Chapelon, Françoise, additional, Tumino, Rosario, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Panico, Salvatore, additional, Ricceri, Fulvio, additional, Redondo, Maria Luisa, additional, Dorronsoro, Miren, additional, Molina‐Montes, Esther, additional, Huerta, José M., additional, Barricarte, Aurelio, additional, Khaw, Kay‐Tee, additional, Wareham, Nick J., additional, Allen, Naomi E., additional, Travis, Ruth, additional, Siersema, Peter D., additional, Peeters, Petra H.M., additional, Trichopoulou, Antonia, additional, Fragogeorgi, Eirini, additional, Oikonomou, Eleni, additional, Boeing, Heiner, additional, Schuetze, Madlen, additional, Canzian, Federico, additional, Lukanova, Annekatrin, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Overvad, Kim, additional, Weiderpass, Elisabete, additional, Gram, Inger Torhild, additional, Lund, Eiliv, additional, Lindkvist, Björn, additional, Johansen, Dorthe, additional, Ye, Weimin, additional, Sund, Malin, additional, Fedirko, Veronika, additional, Jenab, Mazda, additional, Michaud, Dominique S., additional, Riboli, Elio, additional, and Bueno‐de‐Mesquita, H. Bas, additional

Published
2012
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68. Physical activity and risk of breast cancer overall and by hormone receptor status: The European prospective investigation into cancer and nutrition

Author

Steindorf, Karen, primary, Ritte, Rebecca, additional, Eomois, Piia‐Piret, additional, Lukanova, Annekatrin, additional, Tjonneland, Anne, additional, Johnsen, Nina Føns, additional, Overvad, Kim, additional, Østergaard, Jane Nautrup, additional, Clavel‐Chapelon, Françoise, additional, Fournier, Agnès, additional, Dossus, Laure, additional, Teucher, Birgit, additional, Rohrmann, Sabine, additional, Boeing, Heiner, additional, Wientzek, Angelika, additional, Trichopoulou, Antonia, additional, Karapetyan, Tina, additional, Trichopoulos, Dimitrios, additional, Masala, Giovanna, additional, Berrino, Franco, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Quirós, J.Ramón, additional, Travier, Noémie, additional, Sánchez, María‐José, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Bueno‐de‐Mesquita, H.B(as)., additional, van Duijnhoven, Franzel, additional, Monninkhof, Evelyn, additional, May, Anne M., additional, Khaw, Kay‐Tee, additional, Wareham, Nick, additional, Key, Tim J., additional, Travis, Ruth C., additional, Borch, Kristin Benjaminsen, additional, Sund, Malin, additional, Andersson, Anne, additional, Fedirko, Veronika, additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Wahrendorf, Jürgen, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional

Published
2012
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69. Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort

Author

Schlesinger, Sabrina, primary, Aleksandrova, Krasimira, additional, Pischon, Tobias, additional, Fedirko, Veronika, additional, Jenab, Mazda, additional, Trepo, Elisabeth, additional, Boffetta, Paolo, additional, Dahm, Christina C., additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Halkjaer, Jytte, additional, Fagherazzi, Guy, additional, Boutron-Ruault, Marie-Christine, additional, Carbonnel, Franck, additional, Kaaks, Rudolf, additional, Lukanova, Annekatrin, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Lagiou, Pagona, additional, Palli, Domenico, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, HB, Bueno-de-Mesquita, additional, van den Berg, Saskia, additional, Peeters, Petra H.M., additional, Braaten, Tonje, additional, Weiderpass, Elisabete, additional, Quirós, J. Ramón, additional, Travier, Noémie, additional, Sánchez, María-José, additional, Navarro, Carmen, additional, Barricarte, Aurelio, additional, Dorronsoro, Miren, additional, Lindkvist, Björn, additional, Regner, Sara, additional, Werner, Mårten, additional, Sund, Malin, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas, additional, Travis, Ruth C., additional, Norat, Teresa, additional, Wark, Petra A., additional, Riboli, Elio, additional, and Nöthlings, Ute, additional

Published
2012
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70. Obesity, inflammatory markers, and endometrial cancer risk: a prospective case–control study

Author

Dossus, Laure, primary, Rinaldi, Sabina, additional, Becker, Susen, additional, Lukanova, Annekatrin, additional, Tjonneland, Anne, additional, Olsen, Anja, additional, Stegger, Jakob, additional, Overvad, Kim, additional, Chabbert-Buffet, Nathalie, additional, Jimenez-Corona, Aida, additional, Clavel-Chapelon, Francoise, additional, Rohrmann, Sabine, additional, Teucher, Birgit, additional, Boeing, Heiner, additional, Schütze, Madlen, additional, Trichopoulou, Antonia, additional, Benetou, Vassiliki, additional, Lagiou, Pagona, additional, Palli, Domenico, additional, Berrino, Franco, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Redondo, Maria-Luisa, additional, Travier, Noémie, additional, Sanchez, Maria-Jose, additional, Altzibar, Jone M, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Bueno-de-Mesquita, H Bas, additional, van Duijnhoven, Fränzel J B, additional, Onland-Moret, N Charlotte, additional, Peeters, Petra H M, additional, Hallmans, Goran, additional, Lundin, Eva, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas, additional, Allen, Naomi, additional, Key, Tim J, additional, Slimani, Nadia, additional, Hainaut, Pierre, additional, Romaguera, Dora, additional, Norat, Teresa, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional

Published
2010
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72. Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Cust, Anne E, primary, Kaaks, Rudolf, additional, Friedenreich, Christine, additional, Bonnet, Fabrice, additional, Laville, Martine, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Jakobsen, Marianne Uhre, additional, Chajès, Véronique, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Linseisen, Jakob, additional, Lukanova, Annekatrin, additional, Boeing, Heiner, additional, Pischon, Tobias, additional, Trichopoulou, Antonia, additional, Christina, Bamia, additional, Trichopoulos, Dimitrios, additional, Palli, Domenico, additional, Berrino, Franco, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Gram, Inger Torhild, additional, Lund, Eiliv, additional, Quirós, J R, additional, Travier, Noémie, additional, Martínez-García, Carmen, additional, Larrañaga, Nerea, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Berglund, Göran, additional, Lundin, Eva, additional, Bueno-de-Mesquita, H Bas, additional, van Duijnhoven, Fränzel J B, additional, Peeters, Petra H M, additional, Bingham, Sheila, additional, Khaw, Kay-Tee, additional, Allen, Naomi, additional, Key, Tim, additional, Ferrari, Pietro, additional, Rinaldi, Sabina, additional, Slimani, Nadia, additional, and Riboli, Elio, additional

Published
2007
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73. The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Sawada, Norie, Wark, Petra A., Merritt, Melissa A., Tsugane, Shoichiro, Ward, Heather A., Rinaldi, Sabina, Weiderpass, Elisabete, Dartois, Laureen, His, Mathilde, Boutron-Ruault, Marie-Christine, Turzanski-Fortner, Renée, Kaaks, Rudolf, Overvad, Kim, Redondo, María-Luisa, Travier, Noemie, Molina-Portillo, Elena, Dorronsoro, Miren, Cirera, Lluis, Ardanaz, Eva, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Valanou, Elissavet, Masala, Giovanna, Pala, Valeria, HM Peeters, Petra, T. van der Schouw, Yvonne, Melander, Olle, Manjer, Jonas, da Silva, Marisa, Skeie, Guri, Tjønneland, Anne, Olsen, Anja, J. Gunter, Marc, Riboli, Elio, and J. Cross, Amanda

Subjects
Social Sciences, Sociology, Education, Schools, Biology and Life Sciences, Behavior, Habits, Smoking Habits, Medicine and Health Sciences, Neurology, Cerebrovascular Diseases, Stroke, Ischemic Stroke, Vascular Medicine, Nutrition, Diet, Alcohol Consumption, Coronary Heart Disease, Cardiology, Educational Attainment, Public and Occupational Health, Physical Activity, Oncology, Cancer Risk Factors, Hormonal Causes of Cancer
Abstract

Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in ~253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95%CI = 1.00–1.24; women: HRQ5 vs. Q1 = 1.17, 95%CI = 1.07–1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95%CI = 0.56–0.71; women: HRQ5 vs. Q1 = 0.81, 95%CI = 0.70–0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95%CI = 0.55–0.75; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.49–0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95%CI = 0.28–0.71; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.40–0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.

Published
2017
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74. Development and Validation of a Risk Score Predicting Substantial Weight Gain over 5 Years in Middle-Aged European Men and Women

Author

Steffen, Annika, Sørensen, Thorkild I A., Knüppel, Sven, Travier, Noemie, Sánchez, María-José, Huerta, José María, Quirós, J. Ramón, Ardanaz, Eva, Dorronsoro, Miren, Teucher, Birgit, Li, Kuanrong, Bueno-de-Mesquita, H. Bas, van der A, Daphne, Mattiello, Amalia, Palli, Domenico, Tumino, Rosario, Krogh, Vittorio, Vineis, Paolo, Trichopoulou, Antonia, Orfanos, Philippos, Trichopoulos, Dimitrios, Hedblad, Bo, Wallström, Peter, Overvad, Kim, Halkjær, Jytte, Tjønneland, Anne, Fagherazzi, Guy, Dartois, Laureen, Crowe, Francesca, Khaw, Kay-Tee, Wareham, Nick, Middleton, Lefkos, May, Anne M., Peeters, Petra H. M., and Boeing, Heiner

Subjects
Medicine, Clinical Research Design, Cohort Studies, Statistical Methods, Epidemiology, Epidemiology of Aging, Non-Clinical Medicine, Health Care Policy, Health Risk Analysis, Nutrition, Obesity, Public Health, Science Policy
Abstract

Background: Identifying individuals at high risk of excess weight gain may help targeting prevention efforts at those at risk of various metabolic diseases associated with weight gain. Our aim was to develop a risk score to identify these individuals and validate it in an external population. Methods: We used lifestyle and nutritional data from 53°758 individuals followed for a median of 5.4 years from six centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) to develop a risk score to predict substantial weight gain (SWG) for the next 5 years (derivation sample). Assuming linear weight gain, SWG was defined as gaining ≥10% of baseline weight during follow-up. Proportional hazards models were used to identify significant predictors of SWG separately by EPIC center. Regression coefficients of predictors were pooled using random-effects meta-analysis. Pooled coefficients were used to assign weights to each predictor. The risk score was calculated as a linear combination of the predictors. External validity of the score was evaluated in nine other centers of the EPIC study (validation sample). Results: Our final model included age, sex, baseline weight, level of education, baseline smoking, sports activity, alcohol use, and intake of six food groups. The model's discriminatory ability measured by the area under a receiver operating characteristic curve was 0.64 (95% CI = 0.63–0.65) in the derivation sample and 0.57 (95% CI = 0.56–0.58) in the validation sample, with variation between centers. Positive and negative predictive values for the optimal cut-off value of ≥200 points were 9% and 96%, respectively. Conclusion: The present risk score confidently excluded a large proportion of individuals from being at any appreciable risk to develop SWG within the next 5 years. Future studies, however, may attempt to further refine the positive prediction of the score.

Published
2013
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75. Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study.

Author

Guillamó, Elisabet, Cobo-Calvo, Álvaro, Oviedo, Guillermo R., Travier, Noémie, Álamo, Juan, Niño-Mendez, Oscar A., Martínez-Yelamos, Antonio, Martínez-Yelamos, Sergio, and Javierre, Casimiro

Subjects
*MENTAL health, *MULTIPLE sclerosis, *MULTIPLE sclerosis treatment, *FUNCTIONAL assessment, *POSTURAL balance, *EXERCISE physiology, *MUSCLE strength, *PATIENT compliance, *QUALITY of life, *DISEASE relapse, *HOME environment, *WELL-being, *OXYGEN consumption, *MUSCLE fatigue, *CARDIOPULMONARY fitness, *HIGH-intensity interval training
Abstract

Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing- remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO2 peak and in the 30-second sit to stand test was observed in the CFTFG (all p < .05). This study confirms that offering a 40- week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants. [ABSTRACT FROM AUTHOR]

Published
2018

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