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60. Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.

Author

Ito, Y., Kanai, T., Totsuka, T., Okamoto, R., Tsuchiya, K., Nemoto, Y., Yoshioka, A., Tomita, T., Nagaishi, T., Sakamoto, N., Sakanishi, T., Okumura, K., Yagita, H., and Watanabe, M.

Subjects
CELL receptors, T cells, LYMPHOCYTES, INTESTINAL diseases, CELLULAR immunity, GASTROINTESTINAL system
Abstract

It has been recently demonstrated that NKG2D is an activating costimulatory receptor on natural killer (NK) cells, natural killer T (NKT) cells, activated CD8+ T cells, and γδ T cells, which respond to cellular stress, such as inflammation, transformation, and infection. Here we show that intestinal inflammation in colitic SCID mice induced by adoptive transfer of CD4+CD45RBhigh T cells is characterized by significant increase of CD4+NKG2D+ T cells and constitutive expression of NKG2D ligands, such as H60, Mult-1, and Rae-1, by lamina propria CD11c+ dendritic cells. Furthermore, treatment with nondepleting and neutralizing anti-NKG2D MAb after transfer of CD4+CD45RBhigh T cells into SCID mice significantly suppressed wasting disease with colitis, abrogated leukocyte infiltration, and reduced production of IFN-γ by lamina propria CD4+ T cells. These findings demonstrate that NKG2D signaling pathway is critically involved in CD4+ T cell-mediated disease progression and suggest a new therapeutic target for inflammatory bowel diseases. [ABSTRACT FROM AUTHOR]

Published
2008
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61. FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.

Author

Fujii, R., Kanai, T., Nemoto, Y., Makita, S., Oshima, S., Okamoto, R., Tsuchiya, K., Totsuka, T., and Watanabe, M.

Subjects
SPHINGOSINE, BIOGENIC amines, IMMUNOLOGICAL adjuvants, IMMUNOMODULATORS, LYMPHOCYTE transformation, T cells, INFLAMMATORY bowel diseases
Abstract

FFY720, a sphingosine-derived immunomodulator, causes immunosuppression via enhancement of lymphocyte sequestration into secondary lymphoid organs, thereby preventing their antigen-activated T cell egress to sites of inflammation. FTY720 is highly effective in inhibiting autoimmunity in various animal models. However, there is little known about how FTY720 controls the migration property of memory T cells. Here, we demonstrated that FTY720 prevents the development of colitis induced by the adoptive transfer of lamina propria (LP) colitogenic effector memory CD4+ T cells (TEM cells; CD45RBlowCD44highCD62L-) into severe combined immunodeficiency (SCID) mice and suppresses interferon-γ interleukin-2, and tumor necrosis factor-α production by LP CD4+ T cells. The numbers of spleen, peripheral blood, mesenteric lymph node, and LP CD4+ T cells in FTY720-treated mice were significantly reduced compared with those in control mice. Notably, LP CD4+ TEM cells as well as splenic CD4+CD45RBhigh T cells expressed several spingosine-I-phosphate receptors that are targets for FTY720. Furthermore, FTY720 also prevented the development of colitis induced by the adoptive transfer of splenic CD4+CD45RBhigh T cells into SCID mice. Collectively, the present data indicate that FTY720 treatment may offer the potential not only to prevent the onset of disease but also to treat memory T cell-mediated autoimmune diseases including inflammatory bowel diseases. [ABSTRACT FROM AUTHOR]

Published
2006
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62. Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L- effector memory T cells.

Author

Kanai, T., Tanimoto, K., Nemoto, Y., Fujii, R., Makita, S., Totsuka, T., and Watanabe, M.

Subjects
T cells, CELL-mediated lympholysis, CELLULAR immunity, IMMUNOCOMPETENT cells, LYMPHOCYTES, COLITIS
Abstract

Naturally arising CD4+CD25+ regulatory T (TR) cells have been shown to prevent and cure murine T cell-mediated colitis. However, their exact mechanism of controlling colitogenic memory CD4+ T cells in in vivo systems excluding the initial process of naive T cell activation and differentiation has not been examined to date. Using the colitogenic effector memory (TEM) CD4+ cell-mediated colitis model induced by adoptive transfer of colitogenic CD4+CD44highCD62L- lamina propria (LP) T cells obtained from colitic CD4+CD45RBhigh T cell-transferred mice, we have shown in the present study that CD4+CD25+ TR cells are able not only to suppress the development of colitis, Thl cytokine production, and the expansion of colitogenic LP CD4+ TEM cells but also to expand these cells by themselves extensively in vivo. An in vitro coculture assay revealed that CD4+CD25+ TR cells proliferated in the presence of IL-2-producing colitogenic LP CD4+ TEM cells at the early time point (48 h after culture), followed by the acquisition of suppressive activity at the late time point (96 h after culture). Collectively, these data suggest the distinct timing of the IL-2-dependent expansion of CD4+CD25+ TR cells and the their suppressive activity on colitogenic LP CD4+ TEM cells. [ABSTRACT FROM AUTHOR]

Published
2006
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63. Recent results of LH experiments on the JT-60 tokamak

Author

Akaoka, N, primary, Akasaka, H, additional, Akiba, M, additional, Akino, N, additional, Ando, T, additional, Annou, K, additional, Aoyagi, T, additional, Arai, T, additional, Arakawa, K, additional, Araki, M, additional, Azumi, M, additional, Chiba, S, additional, Dairaku, M, additional, Ebisawa, N, additional, Fujii, T, additional, Fukuda, T, additional, Funahashi, A, additional, Furukawa, H, additional, Gunji, H, additional, Hamamatsu, K, additional, Hanada, M, additional, Hara, M, additional, Haraguchi, K, additional, Hiratsuka, H, additional, Hirayama, T, additional, Hiroki, S, additional, Hiruta, K, additional, Honda, M, additional, Horiike, H, additional, Hosogane, N, additional, Iida, Y, additional, Iijima, T, additional, Ikeda, K, additional, Ikeda, Y, additional, Imai, T, additional, Inoue, T, additional, Isaji, N, additional, Isaka, M, additional, Isei, N, additional, Ishida, S, additional, Itami, K, additional, Itige, N, additional, Ito, T, additional, Kakizaki, T, additional, Kamada, Y, additional, Kaminaga, A, additional, Kaneko, T, additional, Kawai, M, additional, Kawabe, M, additional, Kawamata, Y, additional, Kawano, Y, additional, Kikuchi, K, additional, Kikuchi, M, additional, Kimura, H, additional, Kimura, T, additional, Kishimoto, H, additional, Kitamura, S, additional, Kiyono, K, additional, Kodama, K, additional, Koide, Y, additional, Koide, T, additional, Kobayashi, T, additional, Komata, M, additional, Kondo, I, additional, Kondo, T, additional, Konoshima, S, additional, Kubo, H, additional, Kunieda, S, additional, Kurihara, K, additional, Kuriyama, M, additional, Kusaka, M, additional, Kusama, Y, additional, Kushima, T, additional, Maeno, M, additional, Matoba, T, additional, Matsuda, S, additional, Matsukawa, M, additional, Matsuoka, M, additional, Matsuzaki, Y, additional, Miura, Y, additional, Miya, N, additional, Miyachi, K, additional, Miyake, K, additional, Miyo, Y, additional, Mizuno, M, additional, Mogaki, K, additional, Moriyama, S, additional, Murakami, Y, additional, Muto, M, additional, Nagami, M, additional, Nagashima, A, additional, Nagashima, K, additional, Nagashima, T, additional, Nagaya, S, additional, Nagayama, K, additional, Naito, O, additional, Nakamura, H, additional, Nagafuji, T, additional, Nemoto, H, additional, Nemoto, M, additional, Neyatani, Y, additional, Ninomiya, H, additional, Nishino, N, additional, Nishitani, T, additional, Nobusaka, H, additional, Nomata, H, additional, Oikawa, A, additional, Obara, K, additional, Odajima, K, additional, Ogiwara, N, additional, Ohga, T, additional, Ohara, Y, additional, Oohara, H, additional, Ohshima, T, additional, Ohta, K, additional, Ohta, M, additional, Ohuchi, S, additional, Ohuchi, Y, additional, Okumura, H, additional, Omori, K, additional, Omori, S, additional, Omori, Y, additional, Ozeki, T, additional, Saegusa, M, additional, Saitoh, N, additional, Sakasai, A, additional, Sakata, S, additional, Sakuma, T, additional, Sasajima, T, additional, Satou, K, additional, Satou, M, additional, Sawahata, M, additional, Seimiya, M, additional, Seki, M, additional, Seki, S, additional, Shibanuma, K, additional, Shimada, M, additional, Shimizu, K, additional, Shimizu, M, additional, Shimomura, Y, additional, Shinozaki, S, additional, Shirai, H, additional, Shirakata, H, additional, Shitomi, M, additional, Suganuma, K, additional, Sugawara, T, additional, Sugie, T, additional, Sunaoshi, H, additional, Suzuki, M, additional, Suzuki, N, additional, Suzuki, S, additional, Tachibana, H, additional, Takahashi, M, additional, Takahashi, S, additional, Takahashi, T, additional, Takasaki, M, additional, Takatsu, H, additional, Takeuchi, H, additional, Takeshita, A, additional, Takizuka, T, additional, Tamura, S, additional, Tanaka, S, additional, Tanaka, T, additional, Tanaka, Y, additional, Tani, T, additional, Terakado, M, additional, Terakado, T, additional, Tobita, K, additional, Totsuka, T, additional, Toyoshima, N, additional, Tsugita, T, additional, Tsuji, S, additional, Tsukahara, Y, additional, Tsuneoka, M, additional, Uehara, K, additional, Uramoto, Y, additional, Usami, H, additional, Ushigusa, K, additional, Usui, K, additional, Yagyu, J, additional, Yamagishi, K, additional, Yamagiwa, M, additional, Yamamoto, M, additional, Yamashita, O, additional, Yamazaki, T, additional, Yokokura, K, additional, Yokoyama, K, additional, Yoshida, H, additional, Yoshida, Z, additional, Yoshino, R, additional, Yoshioka, Y, additional, Yonekawa, I, additional, and Watanabe, K, additional

Published
1990
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66. ICOS costimulation in inflammatory bowel disease.

Author

Kanai T, Totsuka T, Tezuka K, Watanabe M, Kanai, Takanori, Totsuka, Teruji, Tezuka, Katsunari, and Watanabe, Mamoru

Abstract

For years, medical researchers have striven to develop selective immunotherapies that could specifically ameliorate pathogenic immune responses without immunocompromising the patient. Blockade of many known receptors on T cells can inhibit the initiation of immune responses. However, this approach is problematic in that it is not possible to predict the onset of disease in patients. Current immunotherapies are unsatisfactory for the sporadic exacerbating type of diseases such as multiple sclerosis and inflammatory bowel disease (IBD), because they require either long-term treatment or acute treatment with high-dose immunosuppressants. With regard to this issue, the inducible and inflammatory site-specific molecule, inducible costimulator (ICOS), may be particularly useful as an ideal targeting molecule for the strategy of treatment of human IBD patients. [ABSTRACT FROM AUTHOR]

Published
2002
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67. Role of the innate immune system in the development of chronic colitis.

Author

Kanai T, Iiyama R, Ishikura T, Uraushihara K, Totsuka T, Yamazaki M, Nakamuma T, Watanabe M, Kanai, Takanori, Ilyama, Ryoichi, Ishikura, Takahiro, Uraushihara, Koji, Totsuka, Teruji, Yamazaki, Motomi, Nakamuma, Tetsuya, and Watanabe, Mamoru

Abstract

Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD). [ABSTRACT FROM AUTHOR]

Published
2002
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69. Absorption of atmospheric NO2 by several herbaceous species: estimation by the 15N dilution method.

Author

Okano, K., Machida, T., and Totsuka, T.

Subjects
NITROGEN dioxide, ABSORPTION, DILUTION, SUNFLOWERS, SORGHUM, CORN
Abstract

Absorption of nitrogen dioxide (NO2) by eight herbaceous species was determined by the 13N dilution method. The plants were continuously exposed to NO2 at 0.5 μl l-1 for 2 weeks. Susceptibility of NO2 was simultaneously examined in the tested species to see if this was correlated with the rate of absorption.. The total amount of NO2 -nitrogen absorbed by a plant during the 2 -week exposure period primarily dependent on the size of the plant. Among the tested species, sunflower showed the highest rate of NO2 absorption per unit leaf area, reaching as much as 0.55 mg N dm-2 d-1, which was about four times greater than that for sorghum which had the lowest rate. A highly significant correlation was observed between the rate of absorption and the stomatal conductance among the species. A proportion of the NO2 -nitrogen accumulated in the plant might be absorbed via the air-soil-root route. Sunflower and radish which had higher rates of NO2 absorption than the other species were more susceptible to NO2. On the contrary, sorghum and maize which showed a lower rate of NO2 absorption were tolerant. Consequently, the higher susceptibility to NO2 of radish and sunflower is considered to be directly related to their superior ability to absorb NO2. [ABSTRACT FROM AUTHOR]

Published
1988
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70. 15N DILUTION METHOD FOR ESTIMATING THE ABSORPTION OF ATMOSPHERIC NO2 BY PLANTS.

Author

Okano, K., Fukuzawa, T., Tazaki, T., and Totsuka, T.

Subjects
NITROGEN dioxide, SUNFLOWERS, OILSEED plants, CORN, FORAGE plants, EFFECT of nitrogen on plants
Abstract

The 15N dilution method was used for the quantitative estimation of nitrogen dioxide (NO2) absorbed by Helianthus annuus and Zea mays during a relatively long period. The relationships between the amount of NO2 absorbed and the concentration of NO2 and length of exposure were investigated, in order to ascertain the reliability of this method. The total amount of NO2-nitrogen absorbed by the plants over two weeks (from two to four weeks after the sowing) increased with increasing concentrations of NO2. The rate of absorption of NO2 per unit leaf area also increased linearly with increasing concentrations of NO2 from 0 to 1 μl l-1. This means that the diffusive resistances of stomata or mesophyll tissues were not changed by the continuous exposure to NO2 at 1 μl l-1 for two weeks. The absorption rate per unit leaf area in H. annuus was about three times greater than that in Z. mays. The total amount of NO2-nitrogen absorbed by the plants which were continuously exposed to 0.5 μl l-1 NO2 rose not linearly but exponentially as the exposure time increased from zero to three weeks. This might in part have reflected the growth characteristics of the plants, since dry weight and leaf area increased exponentially during the period of exposure to the pollutant. The absorption rate per unit leaf area remained constant during the first two weeks, but thereafter increased significantly, probably due to the uptake of NO2-nitrogen through the air-soil-root pathway. These results demonstrated that the values estimated by the 15N dilution method were reliable, and this method can be recommended for the quantitative determination of NO2 absorbed by plants during a long period. [ABSTRACT FROM AUTHOR]

Published
1986
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71. ALTERATION OF 13C-ASSIMILATE PARTITIONING IN PLANTS OF <em>PHASEOLUS VULGARIS</em> EXPOSED TO OZONE.

Author

Okano, K., Ito, O., Takeba, G., Shimizu, A., and Totsuka, T.

Subjects
PLANT physiology, PLANT shoots, MERISTEMS, PLANT development, BEANS, OZONE
Abstract

A quantitative tracer experiment was conducted to elucidate the effects of continuous exposure to ozone (O3) at 0.2 μl l-1 on the translocation and the distribution of 13C-labelled photosynthetic assimilates from the individual source leaves in 14-d-old plants of Phaseolus vulgaris. The amount of labelled assimilates exported from the primary leaf, which acted as a main source of photosynthates for growth of the roots, decreased remarkably in the presence of O3 as a result of both a considerable reduction of 13CO2 fixation (62%) and the inhibition of translocation. On the other hand, that from the first trifoliate leaf, which mainly nourished the immature growing leaves, was not decreased in the same way by 03 because a smaller reduction of 13CO2 fixation (24%) was almost compensated by an acceleration of translocation. The pattern of assimilate distribution was altered by O3, so that a greater proportion of assimilates was partitioned to the growing leaves at the expense of the root and the stem. Consequently, the amount of labelled assimilates translocated to the non-photosynthetic organs (stem and root) decreased by 53 %, while that to the photosynthetic organs (leaves) was reduced by only 28%. These results suggest that the plants might have adapted themselves to an environment containing O3, so that the reduction of growth efficiency caused by O3 could be minimized. [ABSTRACT FROM AUTHOR]

Published
1984
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72. Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease

Author

Sato, T., Kanai, T., Watanabe, M., Sakuraba, A., Okamoto, S., Nakai, T., Okazawa, A., Inoue, N., Totsuka, T., Yamazaki, M., Kroczek, R.A., Fukushima, T., Ishii, H., and Hibi, T.

Abstract

Background & Aims: To investigate the role of inducible costimulator (ICOS), a new member of the CD28 family involved in regulation of T-cell activation and chronic intestinal inflammation, we assessed its expression and functional role in patients with inflammatory bowel disease (IBD). Methods: Expression of ICOS, CD28, and cytotoxic T-lymphocyte antigen (CTLA) 4 on intestinal lamina propria mononuclear cells (LPMC) from patients with ulcerative colitis (UC), Crohn's disease (CD), and normal controls was determined using flow cytometry and immunohistochemistry. Expressions of the ICOS ligand, B7h, on lamina propria B cells, macrophages, and epithelial cells (EC) in the intestinal mucosa were also determined using flow cytometry. The functional costimulatory effect of ICOS on LPMC was assessed by the proliferative response and cytokine production. Results: CD4^+ LPMC expressing ICOS was significantly increased in the inflamed mucosa of IBD patients but not in inflammatory or normal controls. B7h was also significantly up-regulated on B cells, macrophages, and EC in inflamed mucosa of IBD patients. Proliferative responses of anti-CD3/ICOS costimulation were significantly higher compared with those of anti-CD3 monoclonal antibody (mAb) alone. Anti-CD3/ICOS-stimulated-LPMC from UC secreted significantly increased amounts of interleukin (IL)-5 among the 3 groups. In contrast, anti-CD3/ICOS-stimulated-LPMC from CD secreted significantly increased amounts of interferon (IFN)-@c in the presence of IL-12. Conclusions: Highly expressed ICOS in activated CD4^+ LPMC of IBD patients contributes to the dysregulated immune responses in IBD. Because ICOS hyperexpression was limited to inflammatory sites in IBD patients, ICOS would be a feasible therapeutic target for the treatment of IBD.

Published
2004
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73. JT-60 Control System

Author

Yonekawa, I., Kawamata, Y., Totsuka, T., Akasaka, H., Sueoka, M., Kurihara, K., and Kimura, T.

Abstract

The present status of the JT-60U control system is reported including its original design concept, the progress of the system, and various modifications since the JT-60 upgrade. This control system has features of a functionally distributed and hierarchical structure, using CAMAC interfaces initially, which have been replaced by versatile module Europe (VME)-bus interfaces, and a protective interlock system composed of both software and hard-wired interlock logics. Plant monitoring and control are performed by efficient data communication through CAMAC highways and Ethernet with TCP/IP protocols. Sequential control of plasma discharges is executed by a combination of a remodeled VME-bus system and a timing system. A real-time plasma control system and a human interface system have been continuously modified corresponding to the progress of JT-60U experiments.

Published
2002
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78. In vivoresponsiveness of thyroid glands to TSH in normal and novel 'growth-retarded' mice: transient elevation in normal mice and impairment in 'growth-retarded' mice

Author

Tomita, K, Yoshida, T, Morita, J, Atsumi, S, and Totsuka, T

Abstract

The in vivoresponsiveness of thyroid glands to TSH at various ages in novel 'growth-retarded' (grt/grt) mice derived from Snell's dwarf (DW/J) mice and in their normal counterparts were analysed by determining serum T4concentrations before and after the administration of exogenous TSH. The serum T4concentration in normal mice increased in response to TSH at 2, 4 and 12 weeks of age but not at 1 week of age. A transient augmentation of such thyroidal responsiveness to TSH was apparent in normal mice at 2 weeks of age, when the serum T4level exhibits a peak and the pubertal growth of mice starts. In contrast to normal mice, at any age examined from 2 to 12 weeks after birth, exogenous TSH did not influence serum T4concentrations in the grt/grtmice at all. On the other hand, serum TSH concentrations in young grt/grtmice were highly elevated compared with those in normal mice and they were normalized by a 2–3 week's treatment with T3. Morphological studies demonstrated degenerated thyroid glands in the grt/grtmice. These results suggest that the severe hypothyroidism and consequent growth retardation in growth-retarded mice are due to impairment of the thyroid glands of the mutant mice in producing and/or secreting thyroid hormones in response to TSH.Journal of Endocrinology(1995) 144,209–214

Published
1995
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79. A novel vascular relaxing agent, N-(6--aminohexyl)-5-chloro-1-naphthalensulfonamide which affects vascular smooth muscle actomyosin.

Author

Hidaka, H, Asano, M, Iwadare, S, Matsumoto, I, Totsuka, T, and Aoki, N

Abstract

The relaxing effect and possible mechanism of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) on isolated rabbit artery were investigated. The addition of W-7 in concentrations ranging from 1 X 10(-6) to 3 X 10(-4) M caused a significant relaxation of isolated rabbit vascular strips contracted by KCl, prostaglandin F2alpha, norepinephrine, histamine, CaCl2, serotonin or angiotensin II. W-7 also caused a shift to the right of the dose-response curves for all agonists tested. Propranolol and atropine did not affect W-7 induced relaxation, suggesting that this drug does not act through beta adrenergic or cholinergic receptors. Superprecipitation of actomyosin from bovine aorta smooth muscle was inhibited by the addition of W-7 in a dose-dependent fashion. The concentration of W-7 which inhibited superprecipitation of bovine aorta smooth muscle actomyosin was in good agreement with the dose producing relaxation of isolated vascular strips. These facts suggest that W-7 produces relaxation of isolated vascular strips by inhibiting actin and myosin interaction.

Published
1978

81. Transfer of nitrogen and carbon from a mature sunflower leaf-15NO2 and 13CO2 feeding studies.

Author

Yoneyama, T, Arai, K, and Totsuka, T

Abstract

To investigate the long-distance transport of nitrogen and carbon from mature leaves, two stable isotopes, (15)N and (13)C, were introduced to a single mature sunflower leaf for less than 2 hr in the forms of NO2 and CO2, and the fate of (15)N and (13)C in plants was followed. In the first experiment, about 4 ppm (15)NO2 was applied to a mature sunflower leaf for 65 min in light, and the fate of (15)N was followed over 72 hr. (15)NO2 absorbed in sunflower was first incorporated into the ethanol-soluble fraction, then gradually incorporated into the ethanol-insoluble fraction: after 24 hr, only 12% remained in the soluble fraction in the fed leaf. Some (15)N was transferred from the fed leaf, first to the stems and next to the young growing leaves and roots, although negligible transfer to other mature leaves was detected. In the second experiment, 3.1 ppm (15)NO2 and 300-400 ppm (13)CO2 were simultaneously introduced to a single mature leaf for 110 min in light, and the fate of the two isotopes was followed for 28 days. Most of the (13)C transfer from the fed leaf took place within 1 day, whereas the transfer of (15)N continued gradually during the experimental period after a small rapid transfer within 1 day. Just after isotope feeding, the ratios of transferred (13)C to (15)N were high in all parts and remained high in the lower stem and the root, although they decreased very rapidly in the upper leaves and the upper stem. In the root, (15)N did not show a significant loss while some (13)C loss occurred during the experimental period. The transfer of (13)C and (15)N to the lower leaves was very low. (13)C Studies showed that carbon of the flower originated from both reserved carbon and current photosynthates.

Published
1980
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82. Selenocysteylation in eukaryotes necessitates the uniquely long aminoacyl acceptor stem of selenocysteine tRNA(Sec).

Author

Sturchler-Pierrat, C, Hubert, N, Totsuka, T, Mizutani, T, Carbon, P, and Krol, A

Abstract

Selenocysteine synthesis is achieved on a specific tRNA, tRNA(Sec), which is first charged with serine to yield seryl-tRNA(Sec). Eukaryotic tRNA(Sec) exhibits an aminoacyl acceptor stem with a unique length of 9 base pairs. Within this stem, two base pairs, G5a.U67b and U6.U67, drew our attention, whose non-Watson-Crick status is maintained in the course of evolution either through U6.U67 base conservation or base covariation at G5a.U67b. Single or double point mutations were performed, which modified the identity of either or both of the base pairs. Serylation by seryl-tRNA synthetase was unaffected by substitutions at either G5a.U67b or U6.U67. Instead, and quite surprisingly, changing G5a.U67b and U6.U67 to G5a-C67b/U6.G67 or G5a-C67b/C6-G67 gave rise to a tRNA(Sec) mutant exhibiting a gain of function in serylation. This finding sheds light on the negative influence born by a few base pairs in the acceptor stem of tRNA(Sec) on its serylation abilities. The tRNA(Sec) capacities to support selenocysteylation were next examined with regard to a possible role played by the two non-Watson-Crick base pairs and the unique length of the acceptor stem. It first emerges from our study that tRNA(Sec) transcribed in vitro is able to support selenocysteylation. Second, none of the point mutations engineered at G5a.U67b and/or U6.U67 significantly modified the selenocysteylation level. In contrast, reduction of the acceptor stem length to 8 base pairs led tRNA(Sec) to lose its ability to efficiently support selenocysteylation. Thus, our study provides strong evidence that the length of the acceptor stem is of prime importance for the serine to selenocysteine conversion step.

Published
1995

83. Gold sodium thiomalate down-regulates intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on vascular endothelial cells.

Author

Koike, R, Miki, I, Otoshi, M, Totsuka, T, Inoue, H, Kase, H, Saito, I, and Miyasaka, N

Abstract

We examined whether antirheumatic drugs alter cytokine- or lipopolysaccharide-induced expression of adhesion molecules on vascular endothelial cells. Human umbilical cord vein endothelial cells were co-cultured with various antirheumatic drugs in the presence of inflammatory cytokines, and adhesion molecule expression was measured by cell enzyme-linked immunosorbent assay and Northern blot analysis. Among these antirheumatic drugs, gold sodium thiomalate significantly inhibited intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on vascular endothelial cells and suppressed cellular binding between human monocytic cell lines, including U937 and HL-60 cells, and interleukin-1 beta-stimulated vascular endothelial cells. It is speculated that down-regulation of adhesion molecules might be one of the novel mechanisms of action of gold sodium thiomalate.

Published
1994

84. Fundamental studies on purification of copper electrolyte.

Author

Totsuka T., Nagai T., Sasaki K., Totsuka T., Nagai T., and Sasaki K.

Abstract

A process is described for removal of arsenic impurities from copper electrolytes by solvent extraction using tri-n-butyl phosphate, followed by stripping of arsenic from the TBP with water., A process is described for removal of arsenic impurities from copper electrolytes by solvent extraction using tri-n-butyl phosphate, followed by stripping of arsenic from the TBP with water.

88. Recent results in JT-60 experiments

Author

Nagami, M, primary, Aoki, I, additional, Akaoka, N, additional, Akasaka, H, additional, Akiba, M, additional, Akino, N, additional, Ando, T, additional, Annou, K, additional, Aoyagi, T, additional, Arai, T, additional, Arakawa, K, additional, Araki, M, additional, Azumi, M, additional, Chiba, S, additional, Dairaku, M, additional, Ebisawa, N, additional, Fujii, T, additional, Fukuda, T, additional, Funahashi, A, additional, Furukawa, H, additional, Gunji, H, additional, Hamamatsu, K, additional, Hanada, M, additional, Hara, M, additional, Haraguchi, K, additional, Hiratsuka, H, additional, Hirayama, T, additional, Hiroki, S, additional, Hiruta, K, additional, Honda, M, additional, Horiike, H, additional, Hosada, R, additional, Hosogane, N, additional, Iida, K, additional, Iida, Y, additional, Iijima, T, additional, Ikeda, K, additional, Ikeda, Y, additional, Imai, T, additional, Inoue, T, additional, Isaji, N, additional, Isaka, M, additional, Ishida, S, additional, Itami, K, additional, Itige, N, additional, Ito, T, additional, Kakizaki, T, additional, Kamada, Y, additional, Kaminaga, A, additional, Kaneko, T, additional, Kato, T, additional, Kawai, M, additional, Kawabe, M, additional, Kawamata, Y, additional, Kawano, Y, additional, Kawasaki, K, additional, Kikuchi, K, additional, Kikuchi, M, additional, Kimura, H, additional, Kimura, T, additional, Kishimoto, H, additional, Kitamura, S, additional, Kiyono, K, additional, Kobayashi, N, additional, Kodama, K, additional, Kurihata, Y, additional, Koide, Y, additional, Koike, T, additional, Komata, M, additional, Kondo, I, additional, Konoshima, S, additional, Kubo, H, additional, Kunieda, S, additional, Kurihara, K, additional, Kuriyama, M, additional, Kusaka, M, additional, Kusama, Y, additional, Kushima, T, additional, Mabuti, Y, additional, Maehara, S, additional, Maeno, K, additional, Matoba, T, additional, Matsuda, S, additional, Matsukawa, M, additional, Matsukawa, T, additional, Matsuoka, M, additional, Matsuzaki, Y, additional, Miura, Y, additional, Miya, N, additional, Miyachi, K, additional, Miyo, Y, additional, Mizuno, M, additional, Mogaki, K, additional, Moriyama, S, additional, Murakami, Y, additional, Muto, M, additional, Nagami, M, additional, Nagase, K, additional, Nagashima, A, additional, Nagashima, K, additional, Nagashima, T, additional, Nagaya, S, additional, Naito, O, additional, Nakamura, H, additional, Nemoto, H, additional, Nemoto, M, additional, Neyatani, Y, additional, Ninomiya, H, additional, Nishino, N, additional, Nishitani, T, additional, Nobusaka, H, additional, Nomata, H, additional, Obara, K, additional, Odajima, K, additional, Ogawa, Y, additional, Ogiwara, N, additional, Ohga, T, additional, Ohara, Y, additional, Oohara, H, additional, Ohshima, T, additional, Ohta, K, additional, Ohta, M, additional, Ohuchi, S, additional, Ohuchi, Y, additional, Okumura, H, additional, Okumura, Y, additional, Omori, K, additional, Omori, S, additional, Omori, Y, additional, Ozeki, T, additional, Saegusa, M, additional, Saitoh, N, additional, Sakasai, A, additional, Sakata, S, additional, Sasajima, T, additional, Sato, K, additional, Sato, M, additional, Sawahata, M, additional, Sebata, T, additional, Seimiya, M, additional, Seki, M, additional, Seki, S, additional, Shibanuma, K, additional, Shimada, M, additional, Shimada, R, additional, Shimizu, K, additional, Shimizu, M, additional, Shimomura, Y, additional, Shinozaki, S, additional, Shirai, H, additional, Shirakata, H, additional, Shitomi, M, additional, Suganuma, K, additional, Sugawara, T, additional, Sugie, T, additional, Sunaoshi, H, additional, Suzuki, M, additional, Suzuki, N, additional, Suzuki, S, additional, Tachibana, H, additional, Takahashi, M, additional, Takahashi, S, additional, Takahashi, T, additional, Takasaki, M, additional, Takatsu, H, additional, Takeuchi, H, additional, Takeshita, A, additional, Takizuka, T, additional, Tamura, S, additional, Tanaka, S, additional, Tanaka, T, additional, Tanaka, Y, additional, Tani, K, additional, Terakado, M, additional, Terakado, T, additional, Tobita, K, additional, Totsuka, T, additional, Toyoshima, N, additional, Tsuda, F, additional, Tsugita, T, additional, Tsuji, S, additional, Tsukahara, Y, additional, Tsuneoka, M, additional, Uehara, K, additional, Uramoto, Y, additional, Usami, H, additional, Ushigusa, K, additional, Usui, K, additional, Yagyu, J, additional, Yamagiwa, M, additional, Yamamoto, M, additional, Yamashita, O, additional, Yamazaki, T, additional, Yokokura, K, additional, Yokoyama, K, additional, Yoshikawa, K, additional, Yoshida, H, additional, Yoshino, R, additional, Yoshioka, Y, additional, Yonekawa, I, additional, Yoneda, T, additional, and Watanabe, K, additional

Published
1989
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89. The JT-60 central control system

Author

Kondo, I., primary, Kimura, T., additional, Yonekawa, I., additional, Kurihara, K., additional, Takahashi, M., additional, Aikawa, H., additional, Hosogane, N., additional, Yoshino, R., additional, Ninomiya, H., additional, Kawamata, Y., additional, Mutoh, M., additional, Totsuka, T., additional, Itoh, Y., additional, Anno, K., additional, Miyachi, K., additional, and Suzuki, Y., additional

Published
1987
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93. Initial experiments in JT-60

Author

Abe, T, primary, Aikawa, H, additional, Akaoka, N, additional, Akasaka, H, additional, Akino, N, additional, Akiyama, T, additional, Ando, T, additional, Anno, K, additional, Aoyagi, T, additional, Arai, T, additional, Arakawa, K, additional, Azumi, M, additional, Fukuda, T, additional, Furukawa, H, additional, Hammamatsu, K, additional, Haraguchi, T, additional, Hayashi, K, additional, Hiratsuka, H, additional, Hirayama, T, additional, Hiroki, S, additional, Hiruta, K, additional, Hitomi, N, additional, Hosoda, R, additional, Hosogane, N, additional, Ichige, H, additional, Iida, S, additional, Iijima, T, additional, Ikeda, Y, additional, Isaji, N, additional, Isaka, M, additional, Ishihara, M, additional, Itoh, Y, additional, Kaneko, M, additional, Kawamata, Y, additional, Kawasaki, K, additional, Kikuchi, M, additional, Kimura, T, additional, Kishimoto, H, additional, Kitahara, K, additional, Kitsunezaki, A, additional, Kodama, K, additional, Koide, Y, additional, Koike, T, additional, Kondo, I, additional, Konoshima, S, additional, Kubo, H, additional, Kunieda, S, additional, Kurihara, K, additional, Kuroda, T, additional, Maeda, H, additional, Maeno, M, additional, Matsukawa, M, additional, Matsukawa, T, additional, Matsuo, M, additional, Miya, N, additional, Miyachi, K, additional, Miyo, Y, additional, Mizuno, M, additional, Murakami, Y, additional, Mutoh, M, additional, Nagami, M, additional, Nagashima, A, additional, Nagashima, K, additional, Nagaya, S, additional, Nakamura, H, additional, Nakamura, Y, additional, Nemoto, M, additional, Neyatani, Y, additional, Niikura, S, additional, Ninomiya, H, additional, Nishitani, T, additional, Nishiyama, T, additional, Nomata, H, additional, Noshiroya, S, additional, Ogiwara, N, additional, Ohasa, K, additional, Ohkubo, M, additional, Ohmori, K, additional, Ohmori, S, additional, Ohmori, Y, additional, Ohsato, Y, additional, Ohshima, T, additional, Ohta, M, additional, Otsu, K, additional, Oikawa, A, additional, Ozeki, T, additional, Sakasai, A, additional, Sakata, S, additional, Sato, M, additional, Seimiya, M, additional, Seki, S, additional, Shiho, M, additional, Shitomi, M, additional, Shimada, R, additional, Shimizu, K, additional, Shimizu, M, additional, Shimomura, Y, additional, Shinozaki, S, additional, Shirai, H, additional, Sugie, T, additional, Sunaoshi, H, additional, Suzuki, K, additional, Suzuki, M, additional, Suzuki, S, additional, Suzuki, Y, additional, Tahira, S, additional, Takahashi, M, additional, Takahashi, S, additional, Takahashi, T, additional, Takatsu, H, additional, Takayasu, Y, additional, Takeda, S, additional, Takeuchi, H, additional, Takizuka, T, additional, Tamura, S, additional, Tanaka, E, additional, Tanaka, T, additional, Tani, K, additional, Terakado, T, additional, Tobita, K, additional, Tokutake, T, additional, Totsuka, T, additional, Toyoshima, N, additional, Tsugita, T, additional, Tsuji, S, additional, Tsukahara, Y, additional, Tsuneoka, M, additional, Ujiie, K, additional, Urakawa, H, additional, Uramoto, Y, additional, Ushigusa, K, additional, Yagyu, J, additional, Yamada, K, additional, Yamamoto, M, additional, Yamashita, O, additional, Yamashita, Y, additional, Yano, K, additional, Yokomizo, H, additional, Yonekawa, I, additional, Yoshida, H, additional, Yoshikawa, M, additional, and Yoshino, R, additional

Published
1986
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94. Characteristics of the JT-60 divertor and limiter plasmas with high power auxiliary heating

Author

Aikawa, H, primary, Akaoka, N, additional, Akasaka, H, additional, Akino, N, additional, Akiyama, T, additional, Ando, T, additional, Annoh, K, additional, Aoyagi, T, additional, Arai, T, additional, Arakawa, K, additional, Araki, M, additional, Azumi, M, additional, Chiba, S, additional, Dairaku, M, additional, Ebisawa, N, additional, Fujii, T, additional, Fukuda, T, additional, Funahashi, A, additional, Furukawa, H, additional, Hamamatsu, K, additional, Hanada, M, additional, Hara, M, additional, Haraguchi, K, additional, Hiratsuka, H, additional, Hirayama, T, additional, Hiroki, S, additional, Hiruta, K, additional, Honda, M, additional, Horiike, H, additional, Hosoda, R, additional, Hosogane, N, additional, Iijima, T, additional, Ikeda, K, additional, Ikeda, Y, additional, Imai, T, additional, Inoue, T, additional, Isaji, N, additional, Isaka, M, additional, Ishida, S, additional, Itami, K, additional, Ichige, N, additional, Itoh, T, additional, Kakizaki, T, additional, Kaminaga, A, additional, Katoh, T, additional, Kawai, M, additional, Kawabe, M, additional, Kawamata, Y, additional, Kawasaki, K, additional, Kikuchi, K, additional, Kikuchi, M, additional, Kimura, H, additional, Kimura, T, additional, Kishimoto, H, additional, Kitamura, S, additional, Kitsunezaki, A, additional, Kiyono, K, additional, Kobayashi, N, additional, Kodama, K, additional, Koide, S, additional, Koide, Y, additional, Koike, T, additional, Komata, M, additional, Kondo, I, additional, Konoshima, S, additional, Kubo, H, additional, Kunieda, S, additional, Kurihara, K, additional, Kuriyama, M, additional, Kuroda, T, additional, Kusaka, M, additional, Kusama, Y, additional, Mabuchi, Y, additional, Maehara, S, additional, Maeno, K, additional, Matoba, T, additional, Matsuda, S, additional, Matsukawa, M, additional, Matsukawa, T, additional, Matsuoka, M, additional, Miura, Y, additional, Miya, N, additional, Miyachi, K, additional, Miyo, Y, additional, Mizuno, M, additional, Mori, M, additional, Moriyama, S, additional, Mutoh, M, additional, Nagami, M, additional, Nagashima, A, additional, Nagashima, K, additional, Nagashima, T, additional, Nagaya, S, additional, Naito, O, additional, Nakamura, H, additional, Nakamura, Y, additional, Nemoto, M, additional, Neyatani, Y, additional, Ninomiya, H, additional, Nishino, N, additional, Nishitani, T, additional, Obara, K, additional, Obinata, H, additional, Ogawa, Y, additional, Ogiwara, N, additional, Ohga, T, additional, Ohara, Y, additional, Ohasa, K, additional, Ohara, H, additional, Ohshima, T, additional, Ohkubo, M, additional, Ohsawa, S, additional, Ohta, K, additional, Ohta, M, additional, Ohtaka, M, additional, Ohuchi, Y, additional, Oikawa, A, additional, Okumura, H, additional, Okumura, Y, additional, Omori, K, additional, Omori, S, additional, Omori, Y, additional, Ozeki, T, additional, Saegusa, M, additional, Saitoh, N, additional, Sakamoto, K, additional, Sakasai, A, additional, Sakata, S, additional, Sasajima, T, additional, Satou, K, additional, Satou, M, additional, Sakurai, A, additional, Sawahata, M, additional, Sebata, T, additional, Seimiya, M, additional, Seki, M, additional, Seki, S, additional, Shibanuma, K, additional, Shimada, R, additional, Shimada, T, additional, Shimizu, K, additional, Shimizu, M, additional, Shimomura, Y, additional, Shinozaki, S, additional, Shirai, H, additional, Shirakata, H, additional, Shitomi, M, additional, Suganuma, K, additional, Sugie, T, additional, Sugiyama, T, additional, Sunaoshi, H, additional, Suzuki, K, additional, Suzuki, M, additional, Suzuki, N, additional, Suzuki, S, additional, Suzuki, Y, additional, Takahashi, M, additional, Takahashi, S, additional, Takahashi, T, additional, Takasaki, M, additional, Takatsu, H, additional, Takeuchi, H, additional, Takeshita, A, additional, Takizuka, T, additional, Tamura, S, additional, Tanaka, S, additional, Tani, K, additional, Terakado, M, additional, Terakado, T, additional, Tobita, K, additional, Tokutake, T, additional, Totsuka, T, additional, Toyoshima, N, additional, Tsuda, F, additional, Tsugita, T, additional, Tsuji, S, additional, Tsukahara, Y, additional, Tsuneoka, M, additional, Uehara, K, additional, Umehara, M, additional, Uramoto, Y, additional, Usami, H, additional, Ushigusa, K, additional, Usui, K, additional, Yagyu, J, additional, Yamagiwa, M, additional, Yamamoto, M, additional, Yamamoto, T, additional, Yamashita, O, additional, Yamazaki, T, additional, Yasukawa, T, additional, Yokokura, K, additional, Yokomizo, H, additional, Yokoyama, K, additional, Yoshikawa, K, additional, Yoshikawa, M, additional, Yoshida, H, additional, Yoshino, R, additional, Yoshioka, Y, additional, Yonekawa, I, additional, Yoneda, T, additional, Watanabe, K, additional, Bell, M.G, additional, Bickerton, R.J, additional, Engelhardt, W, additional, Goldston, R.J, additional, Ilne, E.K, additional, Kaline, J, additional, Kugel, H.W, additional, Mondino, P.L, additional, Soldner, F.X, additional, Takase, Y, additional, Thomas, P.R, additional, and Wong, K.L, additional

Published
1989
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99. High power heating results on JT-60

Author

Akiba, M, primary, Aikawa, H, additional, Akaoka, N, additional, Akasaka, H, additional, Akino, N, additional, Akiyama, T, additional, Ando, T, additional, Annoh, K, additional, Aoyagi, T, additional, Arai, T, additional, Arakawa, K, additional, Araki, M, additional, Azumi, M, additional, Chiba, S, additional, Dairaku, M, additional, Ebisawa, N, additional, Fujii, T, additional, Fukuda, T, additional, Funahashi, A, additional, Furukawa, H, additional, Hamamatsu, K, additional, Hanada, M, additional, Hara, M, additional, Haraguchi, K, additional, Hiratsuka, H, additional, Hirayama, T, additional, Hiroki, S, additional, Hiruta, K, additional, Honda, M, additional, Horiike, H, additional, Hosoda, R, additional, Hosogane, N, additional, Iijima, T, additional, Ikeda, Y, additional, Ikeda, K, additional, Imai, T, additional, Inoue, T, additional, Isaji, N, additional, Isaka, M, additional, Ishida, S, additional, Itami, K, additional, Ichige, N, additional, Itoh, T, additional, Kakizaki, T, additional, Kaminaga, A, additional, Katoh, T, additional, Kawai, M, additional, Kawabe, M, additional, Kawamata, Y, additional, Kawasaki, K, additional, Kikuchi, K, additional, Kikuchi, M, additional, Kimura, H, additional, Kimura, T, additional, Kishimoto, H, additional, Kitamura, S, additional, Kitsunezaki, A, additional, Kiyono, K, additional, Kobayashi, N, additional, Kodama, K, additional, Koide, S, additional, Koide, Y, additional, Kioke, T, additional, Komata, M, additional, Kondo, I, additional, Konoshima, S, additional, Kubo, H, additional, Kunieda, S, additional, Kurihara, K, additional, Kuriyama, M, additional, Kuroda, T, additional, Kusaka, M, additional, Kusama, Y, additional, Mabuchi, Y, additional, Maehara, S, additional, Maeno, K, additional, Matoba, T, additional, Matsuda, S, additional, Matsukawa, M, additional, Matsukawa, T, additional, Matsuoka, M, additional, Miura, Y, additional, Miya, N, additional, Miyachi, K, additional, Mori, Y, additional, Moriyama, S, additional, Mutoh, M, additional, Nagami, M, additional, Nagashima, A, additional, Nagashima, K, additional, Nagashima, T, additional, Nagaya, S, additional, Naitoh, O, additional, Nakamura, H, additional, Nakamura, Y, additional, Nemoto, M, additional, Neyatani, Y, additional, Ninomiya, H, additional, Nishino, N, additional, Nishitani, T, additional, Obara, K, additional, Obinata, H, additional, Ogawa, Y, additional, Ogiwara, N, additional, Ohga, T, additional, Ohara, Y, additional, Ohasa, K, additional, Oohara, H, additional, Ohshima, T, additional, Ohkubo, M, additional, Ohsawa, S, additional, Ohta, K, additional, Ohta, M, additional, Ohtaka, M, additional, Ohuchi, Y, additional, Oikawa, A, additional, Okumura, H, additional, Okumura, Y, additional, Omori, K, additional, Omori, S, additional, Omori, Y, additional, Ozeki, T, additional, Saegusa, M, additional, Saitoh, N, additional, Sakamoto, K, additional, Sakasai, A, additional, Sakata, S, additional, Sasajima, T, additional, Satou, K, additional, Satou, M, additional, Sakurai, A, additional, Sawahata, M, additional, Sebata, T, additional, Seimiya, M, additional, Seki, M, additional, Seki, S, additional, Shibanuma, K, additional, Shimada, R, additional, Shimada, T, additional, Shimizu, K, additional, Shimizu, M, additional, Shimomura, Y, additional, Shinozaki, S, additional, Shirai, H, additional, Shirakata, H, additional, Shitomi, M, additional, Suganuma, K, additional, Sugie, T, additional, Sugiyama, T, additional, Sunaoshi, H, additional, Suzuki, K, additional, Suzuki, M, additional, Suzuki, N, additional, Suzuki, S, additional, Suzuki, Y, additional, Takahashi, M, additional, Takahashi, S, additional, Takahashi, T, additional, Takasaki, M, additional, Takatsu, H, additional, Takeuchi, H, additional, Takeshita, A, additional, Takizuka, T, additional, Tamura, S, additional, Tanaka, S, additional, Tanaka, T, additional, Tani, K, additional, Terakado, M, additional, Terakado, T, additional, Tobita, K, additional, Tokutake, T, additional, Totsuka, T, additional, Toyoshima, N, additional, Tusda, F, additional, Tsugita, T, additional, Tsuji, S, additional, Tsukahara, Y, additional, Tsuneoka, M, additional, Uehara, K, additional, Umechara, M, additional, Uramoto, Y, additional, Usami, H, additional, Ushigusa, K, additional, Usui, K, additional, Yagyu, J, additional, Yamagiwa, M, additional, Yamamoto, M, additional, Yamamoto, T, additional, Yamashita, O, additional, Yamazaki, T, additional, Yasukawa, T, additional, Yokokura, K, additional, Yokomizo, H, additional, Yokoyama, K, additional, Yoshikawa, K, additional, Yoshikawa, M, additional, Yoshida, H, additional, Yoshino, R, additional, Yoshioka, Y, additional, Yonekawa, I, additional, Yoneda, T, additional, Watanabe, K, additional, Bell, M G, additional, Bickerton, R J, additional, Englehardt, W, additional, Goldston, R J, additional, Kallne, E, additional, Kallne, J, additional, Jugel, H W, additional, Mondiono, P L, additional, Solnder, F X, additional, Takase, Y, additional, Thomas, P R, additional, and Wong, K L, additional

Published
1988
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100. JT-60 experiments

Author

Abe, T., primary, Aikawa, H., additional, Akaoka, N., additional, Akasaka, H., additional, Akiba, M., additional, akino, N., additional, Akiyama, T., additional, Ando, T., additional, Anno, K., additional, Aoyagi, T., additional, Arai, T., additional, Arakawa, K., additional, Araki, M., additional, Azumi, M., additional, Dairaku, M., additional, Ebisawa, N., additional, Fujii, T., additional, Fukuda, T., additional, Furukawa, H., additional, Hamamatsu, K., additional, Haraguchi, T., additional, Hayashi, K., additional, Hiratsuka, H., additional, Hirayama, T., additional, lida, K., additional, Hiroki, S., additional, Hiruta, K., additional, Hitomi, N., additional, Honda, M., additional, Horiike, H., additional, Hosoda, R., additional, Hosogane, N., additional, Ichige, H., additional, Iida, S., additional, Iijima, T., additional, Ikeda, Y., additional, Imai, T., additional, Inami, H., additional, Aisaji, N., additional, Isaka, M., additional, Ishihara, M., additional, Itoh, H., additional, Itoh, Y., additional, Kanai, T., additional, Katoh, T., additional, Kawai, M., additional, Kawamata, Y., additional, Kihara, Y., additional, Kawasaki, K., additional, Kikuchi, M., additional, Kimura, H., additional, Kimura, T., additional, Kishimoto, H., additional, Kitahara, K., additional, Kitamura, S., additional, Kutsunezaki, A., additional, Kiyono, K., additional, Kodama, K., additional, Koide, Y., additional, Koike, T., additional, Komata, M., additional, Kondo, I., additional, Konoshima, S., additional, Kubo, H., additional, Kunieda, S., additional, Kurakada, S., additional, Kurihara, K., additional, Kuriyama, M., additional, Kuroda, T., additional, Maeno, M., additional, Matsuda, S., additional, Matsukawa, M., additional, Matsukawa, T., additional, Matsuo, M., additional, Matsuoka, M., additional, Miya, N., additional, Miyachi, K., additional, Miyo, Y., additional, Mizuhashi, K., additional, Mizuno, M., additional, Murakami, Y., additional, Mutoh, M., additional, Nagami, M., additional, Nagashima, A., additional, Nagashima, K., additional, Nagaya, S., additional, Nakamura, H., additional, Nakamura, Y., additional, Nagashima, T., additional, Nemoto, M., additional, Neyatani, Y., additional, Niikura, S., additional, Ninomiya, H., additional, Nishitani, T., additional, Nishiyama, T., additional, Nomata, H., additional, Noshiroya, S., additional, Ogiwara, N., additional, Ohasa, K., additional, Ohga, T., additional, Ohhara, H., additional, Ohkubo, M., additional, Ohmori, K., additional, ohmori, S., additional, Ohmori, Y., additional, ohsato, Y., additional, Ohshima, T., additional, Ohta, M., additional, Ohara, Y., additional, Ohuchi, Y., additional, Okumura, Y., additional, Otsu, K., additional, Oikawa, A., additional, Ozeki, T., additional, Saigusa, M., additional, Sakamoto, K., additional, Sakasai, A., additional, Sakata, S., additional, Sato, M., additional, Sawahata, M., additional, Shibanuma, K., additional, Shibata, T., additional, Seimiya, M., additional, Seki, M., additional, Seki, S., additional, Shitomi, M., additional, Shimada, R., additional, Shimizu, K., additional, Shimizu, M., additional, Shimomura, Y., additional, Shinozaki, S., additional, Shirai, H., additional, Shirakata, H., additional, Suganuma, K., additional, Sugawara, T., additional, Sugie, T., additional, Sunaoshi, H., additional, Suzuki, K., additional, Suzuki, M., additional, Suzuki, N., additional, Suzuki, S., additional, Suzuki, Y., additional, Tahira, S., additional, Takahashi, M., additional, Takahashi, S., additional, Takahashi, T., additional, Takatsu, H., additional, Takayasu, Y., additional, Takeda, S., additional, Takeuchi, H., additional, Takizua, T., additional, Tamura, S., additional, Tanaka, E., additional, Tanaka, S., additional, Tanaka, T., additional, Tani, K., additional, Terakado, T., additional, Tobita, K., additional, Tokutake, T., additional, Totsuka, T., additional, Toyoshima, N., additional, Tsugita, T., additional, Tsuji, S., additional, Tsukahara, Y., additional, Tsuneoka, M., additional, Uehara, K., additional, Uehara, M., additional, Ujiie, K., additional, Urakawa, H., additional, Uramoto, Y., additional, Ushigusa, K., additional, Usui, K., additional, Watanabe, K., additional, Yagyu, J., additional, Yamada, K., additional, Yamamoto, M., additional, Yamashita, O., additional, Yamashita, Y., additional, Yano, K., additional, Yokokura, K., additional, Yokomizo, H., additional, Yonekawa, I., additional, Yoshida, H., additional, Yoshikawa, M., additional, and Yoshino, R., additional

Published
1987
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