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Similarities and differences in performances on 18 verbal and nonverbal memory tasks were studied in young and old alcoholics and in young and old controls as test of hypotheses postulating that cognitive decrements from alcoholism either mimic 'premature aging,' are 'age sensitive,' or are 'independent' from those of normal aging. Young and old alcoholics were matched in length and rate of heavy drinking and were also equated with their controls in age, education, and vocabulary. The multivariate memory and decision data, when converted to independent factor scores, separated alcoholic from control groups on a factor reflecting memory for auditorily presented information. This was independent from factor scores affected mainly by age, such as memory for visuospatial items or decision bias. Age and alcoholism produced overlapping but distinctly different profiles of memory impairments. Decrements in young alcoholics did not resemble those of aging nor did old alcoholics surpass old controls in any but one factor, so that neither the premature aging nor the age sensitivity hypothesis were invariably supported. [ABSTRACT FROM AUTHOR]

Presents a study relating to the mutants of the HIS1 locus of the yeast Saccharomyces cerevisiae (S. cerevisiae), with reference to topical reversion. Materials and methods used; Where revertants were detected; Results and discussion.

Background: The first case of coronavirus disease 2019 (COVID-19) in Alberta, Canada, was confirmed on March 5, 2020. Because the virus testing criteria had changed significantly over this time period, we wanted to ascertain whether previous cases of COVID-19 had been missed in the province., Methods: Our aim was to retrospectively evaluate specimens submitted for respiratory virus testing from December 1, 2019, through March 7, 2020, for undetected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections before the first confirmed case., Results: Testing of 23,517 samples (representing 23,394 patients) identified 1 patient positive for SARS-CoV-2. This specimen was collected on February 24, 2020, from a patient with symptoms consistent with COVID-19 who had recently returned from the western United States. Phylogenetic analysis confirmed this viral isolate belonged to lineage B.1. The epidemiology of this case is consistent with those of other early cases before sustained community transmission, which included a travel history outside of Canada., Conclusion: This exercise provides support that local public health pandemic planning was satisfactory and timely., Competing Interests: The authors have nothing to disclose., (Copyright © 2021, Association of Medical Microbiology and Infectious Disease Canada (AMMI Canada).)

The reaction of the half-open titanocene, Ti(C5H5)(c-C8H11)(PMe3) (c-C8H11 = cyclooctadienyl), with two equivalents of PhC2SiMe3 leads to their incorporation and coupling to the dienyl fragment. One alkyne inserts into a C-H bond of the central CH2 group of the c-C8H11 ligand's edge-bridge, while the second undergoes a 5+2 coupling with the dienyl fragment, yielding coordinated sigma-allyl and olefin fragments, as demonstrated by X-ray diffraction. Together with the C5H5 and PMe3 coordinations, this leads to a 14-electron count. While the very electron-deficient titanium center passes up potential pi coordination of the allyl fragment, it instead engages in interactions with one or two C-C bonds, and perhaps a C-H bond, as revealed from the structural and spectroscopic data. Similar interactions have been found in electron-deficient metallacyclobutane complexes of titanium and zirconium, but not in the 18-electron molybdenum and tungsten analogues. These and other observations may have implications relating to metatheses and polymerizations of olefins.