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412 results on '"Tokita S"'

54. Mechanism of the anti-obesity effects induced by a novel Melanin-concentrating hormone 1-receptor antagonist in mice

Author

Ito, Masahiko, primary, Ishihara, A, additional, Gomori, A, additional, Matsushita, H, additional, Ito, Makoto, additional, Metzger, JM, additional, Marsh, DJ, additional, Haga, Y, additional, Iwaasa, H, additional, Tokita, S, additional, Takenaga, N, additional, Sato, N, additional, MacNeil, DJ, additional, Moriya, M, additional, and Kanatani, A, additional

Published
2009
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81. The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol.

Author

Zoethout, RWM, Iannone, R, Bloem, BR, Palcza, J, Murphy, G, Chodakewitz, J, Buntinx, A, Gottesdiener, K, Marsilio, S, Rosen, L, van Dyck, K, Louis, ED, Cohen, AF, Schoemaker, RC, Tokita, S, Sato, N, Koblan, KS, Hargreaves, RH, Renger, JJ, and van Gerven, JMA

Subjects
MOVEMENT disorders, NEUROLOGICAL disorders, HISTAMINE, ALCOHOL, NEUROLOGY
Abstract

Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA) have demonstrated attenuating effects on ET in the harmaline rat model. In this double-blind, three-way cross-over, single-dose, double-dummy study the effects of 25 mg of a novel H3RIA (MK-0249) and a stable alcohol level (0.6 g L−1) were compared with placebo, in 18 patients with ET. Tremor was evaluated using laboratory tremorography, portable tremorography and a clinical rating scale. The Leeds Sleep Evaluation Questionnaire (LSEQ) and a choice reaction time (CRT) test were performed to evaluate potential effects on sleep and attention, respectively. A steady state of alcohol significantly diminished tremor as assessed by laboratory tremorography, portable tremorography and clinical ratings compared with placebo. A high single MK-0249 dose was not effective in reducing tremor, but caused significant effects on the LSEQ and the CRT test. These results suggest that treatment with a single dose of MK-0249 does not improve tremor in alcohol-responsive patients with ET, whereas stable levels of alcohol as a positive control reproduced the commonly reported tremor-diminishing effects of alcohol. [ABSTRACT FROM PUBLISHER]

Published
2012
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85. Studies on portal circulation (6)

Author

Takahashi, T., Izukura, T., Inoue, J., Takeda, N., Tokita, S., Yasuda, S., Maruyama, Y., Hida, S., Sekizawa, E., Mori, Y., Yokoyama, I., Koshikawa, H., and Shmizu, H.

Published
1967
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98. Recent Advances in Molecular Pharmacology of the Histamine Systems: Physiology and Pharmacology of Histamine H3 Receptor: Roles in Feeding Regulation and Therapeutic Potential for Metabolic Disorders

Author

Tokita Shigeru, Takahashi Kazuhiko, and Kotani Hidehito

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Abstract.: Histamine H3 receptors (H3Rs) are autoreceptors that negatively regulate the release of histamine and other neurotransmitters such as norepinephrine, dopamine, and acetylcholine in the central nervous system (CNS). Consistent with the wide-spread projection of histaminergic neurons from the lateral hypothalamus, H3Rs are widely distributed in the CNS and are believed to play a variety of physiological roles, including regulation of feeding, arousal, cognition, pain, and endocrine systems. To further understand the physiological roles of H3Rs in vivo, we produced H3R knockout (H3R−/−) mice and found that H3R−/− mice displayed hyperphagia and late-onset obesity associated with hyperinsulinemia and leptinemia, the fundamental marks of metabolic syndromes. A series of non-imidazole H3R antagonists/inverse agonists with improved selectivity and potency have been developed and were found to regulate feeding and body weight gain in laboratory animals. Taken together, these observations suggest that H3Rs are involved in the regulation of feeding behavior and body weight. Several H3R inverse agonists targeting cognitive disorders and dementia have entered clinical trials. These trials will give critical information about the physiological functions of H3Rs in humans. Keywords:: histamine, histamine H3 receptor, obesity, central nervous system disorder, inverse agonist

Published
2006
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