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52. Research Training Among Pediatric Residency Programs

Author

Abramson, Erika L, Naifeh, Monique M, Stevenson, Michelle D, Todd, Christopher, Henry, Emilie D, Chiu, Ya-Lin, Gerber, Linda M, and Li, Su-Ting T

Subjects
Health Services and Systems, Health Sciences, Cross-Sectional Studies, Education, Medical, Graduate, Humans, Internship and Residency, Logistic Models, Multivariate Analysis, Pediatrics, Research, United States, Clinical Sciences, Curriculum and Pedagogy, General & Internal Medicine, Curriculum and pedagogy, Health services and systems
Abstract

PurposeThe Accreditation Council for Graduate Medical Education (ACGME) states that "residents should participate in scholarly activity." However, there is little guidance for effectively integrating scholarly activity into residency. This study was conducted to understand how pediatric residency programs meet ACGME requirements and to identify characteristics of successful programs.MethodThe authors conducted an online cross-sectional survey of all pediatric residency program directors in October 2012, assessing program characteristics, resident participation in scholarly activity, program infrastructure, barriers, and outcomes. Multivariate logistic regression was used to identify characteristics of programs in the top quartile for resident scholarly activity participation.ResultsThe response rate was 52.8% (105/199 programs). Seventy-seven (78.6%) programs required scholarly activity, although definitions were variable. When including only original research, systematic reviews or meta-analyses, and case reports or series with references, resident participation averaged 56% (range 0%-100%). Characteristics associated with high-participation programs included a scholarly activity requirement (odds ratio [OR] = 5.5, 95% confidence interval [CI] = 1.03-30.0); program director belief that all residents should present work regionally or nationally (OR = 4.7, 95% CI = 1.5-15.1); and mentorship by >25% of faculty (OR = 3.6, CI = 1.2-11.4). Only 47.1% (41) of program directors were satisfied with resident participation, and only 30.7% (27) were satisfied with the quality of research training provided.ConclusionsThe findings suggest that resident scholarly activity experience is highly variable and suboptimal. Identifying characteristics of successful programs can improve the resident research training experience.

Published
2014

53. Mediating Effect of the NLR on the Relationship Between HbA1c and Left Atrial Stiffness in Overweight Patients With Hypertension.

Author

Zhang, Ri, Pan, Yu, Ren, Yong K, Sun, Qiao B, Fu, Ting T, Zhao, Xu, Liu, Yan, and Jiang, Yi Nong

Subjects
HYPERTENSION, FLOW velocity, OBESITY, GLYCOSYLATED hemoglobin, LINEAR statistical models
Abstract

BACKGROUND We aimed to investigate the association between hemoglobin A1c (HbA1c) and left atrial (LA) stiffness in patients with hypertension and to explore the mediating effect of the neutrophil/lymphocyte ratio (NLR) on this association. METHODS Essential hypertensive patients (n = 292) aged 18–83 years were enrolled and divided into two groups based on the LA stiffness index (LASI): Group I (LASI ≤ 0.32, n = 146) and Group II (LASI > 0.32, n = 146). The LASI was defined as the ratio of early diastolic transmitral flow velocity/lateral mitral annulus myocardial velocity (E / e ʹ) to LA reservoir strain. Multivariate linear regression analysis was performed to determine the independent predictors of the LASI. RESULTS Age, BMI, SBP, HbA1c, CRP, and NLR were significantly greater in Group II than in Group I (P < 0.05). Additionally, Group II had a greater LA volume index (LAVI), left ventricular mass index (LVMI), and early diastolic transmitral flow velocity/lateral mitral annulus myocardial velocity (E / e ʹ) and lower LA reservoir, conduit, and booster pump strains than Group I (P  < 0.001). Univariate and multivariate linear regression models revealed that age, SBP, HbA1c, and the NLR were independently associated with the LASI. Further mediation analysis was performed to determine the mediating effect of the NLR on the association between HbA1c and the LASI and revealed that the NLR had a mediating role only in overweight hypertensive patients, and the proportion of the mediating effect was 21.9%. CONCLUSIONS The NLR was independently correlated with the LASI and played a mediating role in the relationship between HbA1c and the LASI in overweight hypertensive patients. [ABSTRACT FROM AUTHOR]

Published
2024
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54. Flame spread: Effects of microgravity and scale

Author

Urban, David L., Ferkul, Paul, Olson, Sandra, Ruff, Gary A., Easton, John, T'ien, James S., Liao, Ya-Ting T., Li, Chengyao, Fernandez-Pello, Carlos, Torero, Jose L., Legros, Guillaume, Eigenbrod, Christian, Smirnov, Nickolay, Fujita, Osamu, Rouvreau, Sébastien, Toth, Balazs, and Jomaas, Grunde

Published
2019
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55. Down Syndrome–Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes

Author

Jones, Jordan T., Smith, Chelsey, Becker, Mara L., Lovell, Daniel, Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Akoghlanian, S., Al Ahmed, O., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Anastasopoulos, D., Anderson, E., Andrew, M., Ardalan, K., Ardoin, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Birmingham, J., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Brooks, E., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullington, A., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carpenter, S., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chiu, Y., Chundru, K., Clairman, H., Co, D., Collins, K., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Cospito, T., Costanzo, D., Cron, R., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Dionizovik‐Dimanovski, M., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Drummond, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edens, C., Edens, C., Edgerly, Y., Elder, M., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Feldman, B., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleck, D., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gergely, T., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Goh, I., Goldberg, T., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Guevara, M., Guittar, P., Gurion, R., Guzman, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hansman, E., Hanson, A., Harel, L., Haro, S., Harris, J., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hughes, R., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Iqbal, S., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Kahn, P., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khaleel, M., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lang, B., Lapidus, S., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Luca, N., Lvovich, S., Ma, M., Mackey, C., Madison, C., Madison, J., Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCallum, B., McCarthy, K., McConnell, K., McCurdy, D., McCurdy Stokes, P., McGuire, S., McHale, I., McHugh, A., McKibben, K., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Morgan Dewitt, E., Morris, S., Moss, C., Moussa, T., Mruk, V., Mulvhihill, E., Muscal, E., Nahal, B., Nanda, K., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nguyen, E., Nicholas, J., Nigrovic, P., Nocton, J., Oberle, E., Obispo, B., O’Brien, B., O’Brien, T., O’Connor, M., Oliver, M., Olson, J., O’Neil, K., Onel, K., Orlando, M., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Punaro, M., Puplava, B., Quach, J., Quinlan‐Waters, M., Quintero, A., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramsay, E., Ramsey, S., Reed, A., Reed, A., Reed, A., Reid, H., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Roberson, S., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosenwasser Raines, N., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster–Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabatino, M., Sabbagh, S., Sadun, R., Sandborg, C., Sanni, A., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shen, B., Shenoi, S., Shergill, K., Shiff, N., Shirley, J., Shishov, M., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Snider, C., Soep, J., Son, M., Soybilgic, A., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Stasek, J., Steigerwald, K., Sterba Rakovchik, Y., Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stoops, S., Strelow, J., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sura, A., Sutter, M., Syed, R., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Treemarcki, E., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vega‐Fernandes, P., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Wampler Muskardin, T., Wang, C., Waqar, L., Waterfield, M., Watson, M., Watts, A., Waugaman, B., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zemel, L., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.

Published
2021
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56. U(1)' solution to the mu-problem and the proton decay problem in supersymmetry without R-parity

Author

Lee, Hye-Sung, Matchev, Konstantin T., and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology
Abstract

The Minimal Supersymmetric Standard Model (MSSM) is plagued by two major fine-tuning problems: the mu-problem and the proton decay problem. We present a simultaneous solution to both problems within the framework of a U(1)'-extended MSSM (UMSSM), without requiring R-parity conservation. We identify several classes of phenomenologically viable models and provide specific examples of U(1)' charge assignments. Our models generically contain either lepton number violating or baryon number violating renormalizable interactions, whose coexistence is nevertheless automatically forbidden by the new U(1)' gauge symmetry. The U(1)' symmetry also prohibits the potentially dangerous and often ignored higher-dimensional proton decay operators such as QQQL and UUDE which are still allowed by R-parity. Thus, under minimal assumptions, we show that once the mu-problem is solved, the proton is sufficiently stable, even in the presence of a minimum set of exotics fields, as required for anomaly cancellation. Our models provide impetus for pursuing the collider phenomenology of R-parity violation within the UMSSM framework., Comment: Version published in Phys. Rev. D

Published
2007
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57. Collider and Dark Matter Phenomenology of Models with Mirage Unification

Author

Baer, Howard, Park, Eun-Kyung, Tata, Xerxes, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology
Abstract

We examine supersymmetric models with mixed modulus-anomaly mediated SUSY breaking (MM-AMSB) soft terms which get comparable contributions to SUSY breaking from moduli-mediation and anomaly-mediation. The apparent (mirage) unification of soft SUSY breaking terms at Q=mu_mir not associated with any physical threshold is the hallmark of this scenario. The MM-AMSB structure of soft terms arises in models of string compactification with fluxes, where the addition of an anti-brane leads to an uplifting potential and a de Sitter universe, as first constructed by Kachru {\it et al.}. The phenomenology mainly depends on the relative strength of moduli- and anomaly-mediated SUSY breaking contributions, and on the Higgs and matter field modular weights, which are determined by the location of these fields in the extra dimensions. We delineate the allowed parameter space for a low and high value of tan(beta), for a wide range of modular weight choices. We calculate the neutralino relic density and display the WMAP-allowed regions. We show the reach of the CERN LHC and of the International Linear Collider. We discuss aspects of MM-AMSB models for Tevatron, LHC and ILC searches, muon g-2 and b->s \gamma branching fraction. We also calculate direct and indirect dark matter detection rates, and show that almost all WMAP-allowed models should be accessible to a ton-scale noble gas detector. Finally, we comment on the potential of colliders to measure the mirage unification scale and modular weights in the difficult case where mu_mir>>M_GUT., Comment: 34 pages plus 42 EPS figures; version with high resolution figures is at http://www.hep.fsu.edu/~baer

Published
2007
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58. Measuring Modular Weights in Mirage Unification Models at the LHC and ILC

Author

Baer, Howard, Park, Eun-Kyung, Tata, Xerxes, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

String compactification with fluxes yields MSSM soft SUSY breaking terms that receive comparable contributions from modulus and anomaly mediation whose relative strength is governed by a phenomenological parameter $\alpha$. Gaugino and first/second generation (and sometimes also Higgs and third generation) scalar mass parameters unify at a mirage unification scale $Q \not= M_{\rm GUT}$, determined by the value of $\alpha$. The ratio of scalar to gaugino masses at this mirage unification scale depends directly on the scalar field modular weights, which are fixed in turn by the brane or brane intersections on which the MSSM fields are localized. We outline a program of measurements which can in principle be made at the CERN LHC and the International Linear $e^+e^-$ collider (ILC) which can lead to a determination of the modular weights., Comment: 8 pages, 2 figures

Published
2006
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59. Collider and Dark Matter Searches in Models with Mixed Modulus-Anomaly Mediated SUSY Breaking

Author

Baer, Howard, Park, Eun-Kyung, Tata, Xerxes, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We investigate the phenomenology of supersymmetric models where moduli fields and the Weyl anomaly make comparable contributions to SUSY breaking effects in the observable sector of fields. This mixed modulus-anomaly mediated supersymmetry breaking (MM-AMSB) scenario is inspired by models of string compactification with fluxes, which have been shown to yield a de Sitter vacuum (as in the recent construction by Kachru {\it et al}). The phenomenology depends on the so-called modular weights which, in turn, depend on the location of various fields in the extra dimensions. We find that the model with zero modular weights gives mass spectra characterized by very light top squarks and/or tau sleptons, or where M_1\sim -M_2 so that the bino and wino are approximately degenerate. The top squark mass can be in the range required by successful electroweak baryogenesis. The measured relic density of cold dark matter can be obtained via top squark co-annihilation at low \tan\beta, tau slepton co-annihilation at large \tan\beta or via bino-wino coannihilation. Then, we typically find low rates for direct and indirect detection of neutralino dark matter. However, essentially all the WMAP-allowed parameter space can be probed by experiments at the CERN LHC, while significant portions may also be explored at an e^+e^- collider with \sqrt{s}=0.5--1 TeV. We also investigate a case with non-zero modular weights. In this case, co-annihilation, A-funnel annihilation and bulk annihilation of neutralinos are all allowed. Results for future colliders are qualitatively similar, but prospects for indirect dark matter searches via gamma rays and anti-particles are somewhat better., Comment: 38 pages including 22 EPS figures; latest version posted to conform with published version

Published
2006
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60. Outside the mSUGRA Box

Author

Bourjaily, Jacob L., Kane, Gordon L., Kumar, Piyush, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, High Energy Physics - Theory
Abstract

Most studies of the potential for discovery of superpartners at the Fermilab Tevatron or CERN LHC have focused on the so-called mSUGRA (minimal supergravity mediated supersymmetry breaking) model, not because it is well motivated but because it has a minimal number of parameters. If signals are seen that could be superpartners, most analyses will attempt to interpret them in the mSUGRA framework since the needed software and computational tools exist. With only a few signal channels, and initially large statistical and systematic errors, it is very likely that an mSUGRA interpretation will look all right even if it is not. We present an approach to studying any potential signals of new physics in ``inclusive signature space'' that sensitively tests any proposed interpretation, and apply it to the mSUGRA case. The approach also has significant experimental advantages, reducing the sensitivity to jet energy corrections, dependence on beam luminosity, and other systematics. Basically, if one (or more) instances of reported data lies outside certain bounded regions of inclusive signature space characteristic of the physics being tested, that physics is excluded for any parameters. The approach can be used to study supersymmetry breaking and to point to the form of the underlying theory even without detailed measurements of a number of important parameters which will be difficult or impossible to measure at hadron colliders.

Published
2005

61. The minimal U(1)' extension of the MSSM

Author

Demir, Durmus A., Kane, Gordon L., and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

Motivated by the apparent need for extending the MSSM and perhaps mitigating naturalness problems associated with the $\mu$ parameter and fine-tuning of the soft masses, we augment the MSSM spectrum by a SM gauge singlet chiral superfield, and enlarge the gauge structure by an additional U(1)' invariance, so that the gauge and Higgs sectors are relatively secluded. One crucial aspect of U(1)' models is the existence of anomalies, cancellation of which may require the inclusion of exotic matter which in turn disrupts the unification of the gauge couplings. In this work we pursue the question of canceling the anomalies with a minimal matter spectrum and no exotics. This can indeed be realized provided that U(1)' charges are family-dependent and the soft-breaking sector includes non-holomorphic operators for generating the fermion masses. We provide the most general solutions for U(1)' charges by taking into account all constraints from gauge invariance and anomaly cancellation. We analyze various laboratory and astrophysical bounds ranging from fermion masses to relic density, for an illustrative set of parameters. The U(1)' charges admit patterns of values for which family nonuniversality resides solely in the lepton sector, though this does not generate leptonic FCNCs due to the U(1)' gauge invariance., Comment: 28 pages, no figures. References added

Published
2005
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66. Some Phenomenology of Intersecting D-Brane Models

Author

Kane, Gordon L., Kumar, Piyush, Lykken, Joseph D., and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We present some phenomenology of a new class of intersecting D-brane models. Soft SUSY breaking terms for these models are calculated in the u - moduli dominant SUSY breaking approach (in type IIA). In this case, the dependence of the soft terms on the Yukawas and Wilson lines drops out. These soft terms have a different pattern compared to the usual heterotic string models. Phenomenological implications for dark matter are discussed., Comment: 29 pages, 1 figure, References added

Published
2004
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67. High Scale Study of Possible B \to \phi K_S CP Physics

Author

Kane, Gordon L., Wang, Haibin, Wang, Lian-Tao, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology
Abstract

Some rare decay processes are particularly sensitive to physics beyond the Standard Model (SM) because they have no SM tree contributions. We focus on one of these, $B_{d}\to \phi K_{s}$. Our study is in terms of the high scale effective theory, and high scale models for the underlying theory, while previous studies have been focusing on the low scale effective Lagrangian. We examine phenomenologically the high scale parameter space with full calculations, but largely report the results in terms of mass insertion techniques since they are then easily pictured. We also determine the ranges of different mass insertions that could produce large non-SM CP effects. Then we exhibit classes of high scale models that can or cannot provide large non-SM CP effects, thus demonstrating that data on $B_{d}\to \phi K_{s}$ can probe both supersymmetry breaking and the underlying high scale theory and even make relatively direct contact with string-motivated models. We provide a novel and systematic technique to understand the relations between high and low scale parameters from RGE running. We include all constraints from other data, particularly $b\to s\gamma$ and EDMs., Comment: 31 pages, 8 figures

Published
2004

68. Theoretical Implications of the LEP Higgs Search

Author

Kane, G. L., Nelson, Brent D., Wang, Lian-Tao, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology
Abstract

We study the implications for the minimal supersymmetric standard model (MSSM) of the absence of a direct discovery of a Higgs boson at LEP. First we exhibit 15 physically different ways in which one or more Higgs bosons lighter than the LEP limit could still exist. For each of these cases -- as well as the case that the lightest Higgs eigenstate is at, or slightly above, the current LEP limit -- we provide explicit sample configurations of the Higgs sector as well as the soft supersymmetry breaking Lagrangian parameters necessary to generate these outcomes. We argue that all of the cases seem fine-tuned, with the least fine-tuned outcome being that with Higgs mass near 115 GeV. Seeking to minimize this tuning we investigate ways in which the ``maximal-mixing'' scenario with large top-quark trilinear A-term can be obtained from simple string-inspired supergravity models. We find these obvious approaches lead to heavy gauginos and/or problematic low-energy phenomenology with minimal improvement in fine-tuning., Comment: 24 pages; uses RevTeX

Published
2004
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69. Relating Incomplete Data and Incomplete Theory

Author

Binetruy, Pierre, Kane, G. L., Nelson, Brent D., Wang, Lian-Tao, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, High Energy Physics - Theory
Abstract

Assuming string theorists will not soon provide a compelling case for the primary theory underlying particle physics, the field will proceed as it has historically: with data stimulating and testing ideas. Ideally the soft supersymmetry breaking Lagrangian will be measured and its patterns will point to the underlying theory. But there are two new problems. First a matter of principle: the theory may be simplest at distance scales and in numbers of dimensions where direct experiments are not possible. Second a practical problem: in the foreseeable future (with mainly hadron collider data) too few observables can be measured to lead to direct connections between experiment and theory. In this paper we discuss and study these issues and consider ways to circumvent the problems, studying models to test methods. We propose a semi-quantitative method for focusing and sharpening thinking when trying to relate incomplete data to incomplete theory, as will probably be necessary., Comment: 43 pages, 1 figure

Published
2003
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70. Phenomenology and Theory of Possible Light Higgs Bosons

Author

Kane, G. L., Nelson, Brent D., Wang, Lian-Tao, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, High Energy Physics - Theory
Abstract

We study the implications of the absence of a direct discovery of a Higgs boson at LEP. First we exhibit 15 physically different ways in which one or more Higgs bosons lighter than the LEP limit could still exist. In the minimal supersymmetric standard model (MSSM) all of these, as well as the cases where the Higgs mass equals or exceeds 115 GeV, seem fine-tuned. We examine some interpretations of the fine tuning in high scale theories. The least fine-tuned MSSM outcome will have a Higgs mass at 115 GeV, while approaches that extend the MSSM at the weak scale can naturally have larger Higgs masses., Comment: Uses RevTeX; references added

Published
2003

71. Theory-Motivated Benchmark Models and Superpartners at the Tevatron

Author

Kane, G. L., Lykken, J., Mrenna, Stephen, Nelson, Brent D., Wang, Lian-Tao, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology
Abstract

Recently published benchmark models have contained rather heavy superpartners. To test the robustness of this result, several benchmark models have been constructed based on theoretically well-motivated approaches, particularly string-based ones. These include variations on anomaly and gauge-mediated models, as well as gravity mediation. The resulting spectra often have light gauginos that are produced in significant quantities at the Tevatron collider, or will be at a 500 GeV linear collider. The signatures also provide interesting challenges for the LHC. In addition, these models usually account for electroweak symmetry breaking with relatively less fine-tuning than previous benchmark models., Comment: 44 pages, 4 figures; some typos corrected. Revisions reflect published version

Published
2002
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72. Supersymmetry and the Cosmic Ray Positron Excess

Author

Kane, Gordon L., Wang, Lian-Tao, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology, Astrophysics
Abstract

We explore several supersymmetric alternatives to explain predictions for the cosmic ray positron excess. Light sneutrino or neutralino LSP's, and a fine-tuned model designed to provide a delta-function input, can give adequate statistical descriptions of the reported HEAT data if non-thermal production of the relic cold dark matter density dominates and/or if ``boost factors''(that could originate in uncertainties from propagation or local density fluctuations) to increase the size of the signal are included. All the descriptions can be tested at the Tevatron or LHC, and some in other WIMP detecting experiments., Comment: 15 pages, 3 figures

Published
2002
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73. Alternative approach to $b->s \gamma$ in the uMSSM

Author

Everett, L., Kane, G. L., Rigolin, S., Wang, Lian-Tao, and Wang, Ting T.

Subjects
High Energy Physics - Phenomenology
Abstract

The gluino contributions to the $C'_{7,8}$ Wilson coefficients for $b->s \gamma$ are calculated within the unconstrained MSSM. New stringent bounds on the $\delta^{RL}_{23}$ and $\delta^{RR}_{23}$ mass insertion parameters are obtained in the limit in which the SM and SUSY contributions to $C_{7,8}$ approximately cancel. Such a cancellation can plausibly appear within several classes of SUSY breaking models in which the trilinear couplings exhibit a factorized structure proportional to the Yukawa matrices. Assuming this cancellation takes place, we perform an analysis of the $b->s \gamma$ decay. We show that in a supersymmetric world such an alternative is reasonable and it is possible to saturate the $b->s \gamma$ branching ratio and produce a CP asymmetry of up to 20%, from only the gluino contribution to $C'_{7,8}$ coefficients. Using photon polarization a LR asymmetry can be defined that in principle allows for the $C_{7,8}$ and $C'_{7,8}$ contributions to the $b->s \gamma$ decay to be disentangled. In this scenario no constraints on the ``sign of $\mu$'' can be derived., Comment: LaTeX2e, 23 pages, 7 ps figure, needs package epsfig

Published
2001
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74. Juvenile Spondyloarthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: High Biologic Use, Low Prevalence of HLA–B27, and Equal Sex Representation in Sacroiliitis

Author

Rumsey, Dax G., Lougee, Aimee, Matsouaka, Roland, Collier, David H., Schanberg, Laura E., Schenfeld, Jennifer, Shiff, Natalie J., Stoll, Matthew L., Stryker, Scott, Weiss, Pamela F., Beukelman, Timothy, Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Magni Manzoni, S., Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., McCurdy Stokes, P., McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Morgan Dewitt, E., Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O’Brien, B., O’Brien, T., Okeke, O., Oliver, M., Olson, J., O’Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Pires Marafon, D., Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Sterba Rakovchik, Y., Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Wampler Muskardin, T., Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.

Published
2021
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75. Pediatric resident and faculty attitudes toward self-assessment and self-directed learning: a cross-sectional study

Author

Li, Su-Ting T, Favreau, Michele A, and West, Daniel C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Behavioral and Social Science, Pediatric, Clinical Research, Quality Education, Attitude, Cross-Sectional Studies, Education, Medical, Continuing, Faculty, Medical, Female, Humans, Internship and Residency, Male, Pediatrics, Programmed Instructions as Topic, Self-Assessment, Public Health and Health Services, Curriculum and Pedagogy, Medical Informatics, Clinical sciences, Curriculum and pedagogy, Specialist studies in education
Abstract

BackgroundThe development of self-assessment and self-directed learning skills is essential to lifelong learning and becoming an effective physician. Pediatric residents in the United States are now required to use Individualized Learning Plans (ILPs) to document self-assessment and self-directed learning. A better understanding of resident and faculty attitudes and skills about self-assessment and self-directed learning will allow more successful integration of lifelong learning into residency education. The objective of this study was to compare faculty and resident attitudes, knowledge and skills about self-assessment, self-directed learning and ILPs.MethodsSurvey of pediatric residents and faculty at a single institution. Respondents rated their attitudes, knowledge, and self-perceived skills surrounding self-assessment, self-directed learning and ILPs.ResultsOverall survey response rate was 81% (79/97); 100% (36/36) residents and 70% (43/61) faculty. Residents and faculty agreed that lifelong learning is a necessary part of being a physician. Both groups were comfortable with assessing their own strengths and weaknesses and developing specific goals to improve their own performance. However, residents were less likely than faculty to continuously assess their own performance (44% vs. 81%; p < 0.001) or continuously direct their own learning (53% vs. 86%; p < 0.001). Residents were more likely than faculty to believe that residents should be primarily responsible for directing their own learning (64% vs. 19%; p < 0.0001), but at the same time, more residents believed that assigned clinical (31% vs. 0%; p < 0.0001) or curricular (31% vs. 0%; p < 0.0001) experiences were sufficient to make them competent physicians. Interns were less likely than senior residents to have a good understanding of how to assess their own skills (8% vs. 58%; p = 0.004) or what it means to be a self-directed learner (50% vs. 83%; p = 0.04).Qualitative comments indicated that while ILPs have the potential to help learners develop individualized, goal-directed learning plans based on strengths and weaknesses, successful implementation will require dedicated time and resident and faculty development.ConclusionThese findings suggest that training and experience are necessary for physicians to understand the role of self-directed learning in education. Deliberate practice, for example by requiring residents to use ILPs, may facilitate self-directed, lifelong learning.

Published
2009

81. Comparative Effectiveness of a Second Tumor Necrosis Factor Inhibitor Versus a Non–Tumor Necrosis Factor Biologic in the Treatment of Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis

Author

Mannion, Melissa L., Amin, Shahla, Balevic, Stephen, Chang, Min‐Lee, Correll, Colleen K., Kearsley‐Fleet, Lianne, Hyrich, Kimme L., Beukelman, Timothy, Aamir, R., Abulaban, K., Adams, A., Aguiar Lapsia, C., Akinsete, A., Akoghlanian, S., Al Manaa, M., AlBijadi, A., Allenspach, E., Almutairi, A., Alperin, R., Amarilyo, G., Ambler, W., Amoruso, M., Angeles‐Han, S., Ardoin, S., Armendariz, S., Asfaw, L., Aviran Dagan, N., Bacha, C., Balboni, I., Balevic, S., Ballinger, S., Baluta, S., Barillas‐Arias, L., Basiaga, M., Baszis, K., Baxter, S., Becker, M., Begezda, A., Behrens, E., Beil, E., Benseler, S., Bermudez‐Santiago, L., Bernal, W., Bigley, T., Bingham, C., Binstadt, B., Black, C., Blackmon, B., Blakley, M., Bohnsack, J., Boneparth, A., Bradfield, H., Bridges, J., Brooks, E., Brothers, M., Brunner, H., Buckley, L., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Canna, S., Cannon, L., Canny, S., Cartwright, V., Cassidy, E., Castro, D., Chalom, E., Chang, J., Chang, M., Chang, J., Chang‐Hoftman, A., Chen, A., Chiraseveenuprapund, P., Ciaglia, K., Co, D., Cohen, E., Collinge, J., Conlon, H., Connor, R., Cook, K., Cooper, A., Cooper, J., Corbin, K., Correll, C., Cron, R., Curry, M., Dalrymple, A., Datyner, E., Davis, T., De Ranieri, D., Dean, J., DeCoste, C., Dedeoglu, F., DeGuzman, M., Delnay, N., DeSantis, E., Devine, R., Dhalla, M., Dhanrajani, A., Dissanayake, D., Dizon, B., Drapeau, N., Drew, J., Driest, K., Du, Q., Duncan, E., Dunnock, K., Durkee, D., Dvergsten, J., Eberhard, A., Ede, K., Edelheit, B., Edens, C., El Tal, T., Elder, M., Elzaki, Y., Fadrhonc, S., Failing, C., Fair, D., Favier, L., Feldman, B., Fennell, J., Ferguson, P., Ferguson, I., Figueroa, C., Flanagan, E., Fogel, L., Fox, E., Fox, M., Franklin, L., Fuhlbrigge, R., Fuller, J., Furey, M., Futch‐West, T., Gagne, S., Gennaro, V., Gerstbacher, D., Gilbert, M., Gironella, A., Glaser, D., Goh, I., Goldsmith, D., Gorry, S., Goswami, N., Gottlieb, B., Graham, T., Grevich, S., Griffin, T., Grim, A., Grom, A., Guevara, M., Hahn, T., Halyabar, O., Hamda Natur, M., Hammelev, E., Hammond, T., Harel, L., Harris, J., Harry, O., Hausmann, J., Hay, A., Hays, K., Hayward, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horton, D., Horwitz, M., Hsu, J., Huber, A., Huberts, A., Huggins, J., Huie, L., Hui‐Yuen, J., Ibarra, M., Imlay, A., Imundo, L., Inman, C., Jackson, A., James, K., Janow, G., Jared, S., Jiang, Y., Johnson, L., Johnson, N., Jones, J., Kafisheh, D., Kahn, P., Kaidar, K., Kasinathan, S., Kaur, R., Kessler, E., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Knight, A., Kovalick, L., Kramer, S., Kremer, C., Kudas, O., LaFlam, T., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Lawler, C., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lee, A., Leisinger, E., Lentini, L., Lerman, M., Levinsky, Y., Levy, D., Li, S., Lieberman, S., Lim, L., Limenis, E., Lin, C., Ling, N., Lionetti, G., Livny, R., Lloyd, M., Lo, M., Long, A., Lopez‐Peña, M., Lovell, D., Luca, N., Lvovich, S., Lytch, A., Ma, M., Machado, A., MacMahon, J., Madison, J., Mannion, M., Manos, C., Mansfield, L., Marston, B., Mason, T., Matchett, D., McAllister, L., McBrearty, K., McColl, J., McCurdy, D., McDaniels, K., McDonald, J., Meidan, E., Mellins, E., Mian, Z., Miettunen, P., Miller, M., Milojevic, D., Mitacek, R., Modica, R., Mohan, S., Moore, T., Moore, K., Moorthy, L., Moreno, J., Morgan, E., Moyer, A., Murante, B., Murphy, A., Muscal, E., Mwizerwa, O., Najafi, A., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Nearanz, K., Neely, J., Newhall, L., Nguyen, A., Nigrovic, P., Nocton, J., Nolan, B., Nowicki, K., Oakes, R., Oberle, E., Ogbonnaya‐Whittesley, S., Ogbu, E., Oliver, M., Olveda, R., Onel, K., Orandi, A., Padam, J., Paller, A., Pan, N., Pandya, J., Panupattanapong, S., Toledano, A. Pappo, Parsons, A., Patel, J., Patel, P., Patrick, A., Patrizi, S., Paul, S., Perfetto, J., Perron, M., Peskin, M., Ponder, L., Pooni, R., Prahalad, S., Puplava, B., Quinlan‐Waters, M., Rabinovich, C., Rafko, J., Rahimi, H., Rampone, K., Ramsey, S., Randell, R., Ray, L., Reed, A., Reed, A., Reid, H., Reiff, D., Richins, S., Riebschleger, M., Rife, E., Riordan, M., Riskalla, M., Robinson, A., Robinson, L., Rodgers, L., Rodriquez, M., Rogers, D., Ronis, T., Rosado, A., Rosenkranz, M., Rosenwasser, N., Rothermel, H., Rothman, D., Rothschild, E., Roth‐Wojcicki, E., Rouster‐Stevens, K., Rubinstein, T., Rupp, J., Ruth, N., Sabbagh, S., Sadun, R., Santiago, L., Saper, V., Sarkissian, A., Scalzi, L., Schahn, J., Schikler, K., Schlefman, A., Schmeling, H., Schmitt, E., Schneider, R., Schulert, G., Schultz, K., Schutt, C., Seper, C., Sheets, R., Shehab, A., Shenoi, S., Sherman, M., Shirley, J., Shishov, M., Siegel, D., Singer, N., Sivaraman, V., Sloan, E., Smith, C., Smith, J., Smitherman, E., Soep, J., Son, Mary B., Sosna, D., Spencer, C., Spiegel, L., Spitznagle, J., Srinivasalu, H., Stapp, H., Steigerwald, K., Stephens, A., Sterba Rakovchik, Y., Stern, S., Stevens, B., Stevenson, R., Stewart, K., Stewart, W., Stingl, C., Stoll, M., Stringer, E., Sule, S., Sullivan, J., Sundel, R., Sutter, M., Swaffar, C., Swayne, N., Syed, R., Symington, T., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Tesher, M., Thakurdeen, T., Theisen, A., Thomas, B., Thomas, L., Thomas, N., Ting, T., Todd, C., Toib, D., Toib, D., Torok, K., Tory, H., Toth, M., Tse, S., Tsin, C., Twachtman‐Bassett, J., Twilt, M., Valcarcel, T., Valdovinos, R., Vallee, A., Van Mater, H., Vandenbergen, S., Vannoy, L., Varghese, C., Vasquez, N., Vega‐Fernandez, P., Velez, J., Verbsky, J., Verstegen, R., Scheven, E., Vora, S., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, B., Walters, H., Waterfield, M., Waters, A., Weiser, P., Weiss, P., Weiss, J., Wershba, E., Westheuser, V., White, A., Widrick, K., Williams, C., Wong, S., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yasin, S., Yeung, R., Yomogida, K., Zeft, A., Zhang, Y., Zhao, Y., and Zhu, A.

Abstract

The objective of this study was to compare the effectiveness of a second tumor necrosis factor inhibitor (TNFi) versus a non‐TNFi biologic following discontinuation of a TNFi for patients with polyarticular‐course juvenile idiopathic arthritis (pJIA). Using the Childhood Arthritis and Rheumatology Research Alliance Registry, patients with pJIA who started receiving a second biologic following a first TNFi were identified. Patients were required to have no active uveitis on the index date and a visit six months after the index date. Outcome measures included Clinical Juvenile Arthritis Disease Activity Score with a maximum of 10 active joints (cJADAS10), cJADAS10 inactive disease (ID; ≤2.5) and cJADAS10 minimal disease activity (MiDA; ≤5). Multiple imputation was used to account for missing data. Adjusted odds ratios (aORs) were calculated using propensity score quintiles to compare outcomes at six months following second biologic initiation. There were 216 patients included, 84% initially received etanercept, and most patients stopped receiving it because of its ineffectiveness (74%). A total of 183 (85%) started receiving a second TNFi, and 33 (15%) started receiving a non‐TNFi. Adalimumab was the most common second biologic received (71% overall, 84% of second TNFi), and tocilizumab was the most common non‐TNFi second biologic received (9% overall, 58% of non‐TNFi). There was no difference between receiving TNFi versus non‐TNFi in cJADAS10 ID (29% vs 25%; aOR 1.23, 95% confidence interval [CI] 0.47–3.20) or at least MiDA (43% vs 39%; aOR 1.11, 95% CI 0.47–2.62) at six months. Most patients with pJIA started receiving TNFi rather than non‐TNFi as their second biologic, and there were no differences in disease activity at six months.

Published
2024
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83. Upward flame spread over discrete thin solids separated by heat-absorbing inert materials

Author

Wohan Cui, Ankit Sharma, and Ya-Ting T Liao

Subjects
Mechanics of Materials, Mechanical Engineering, Safety, Risk, Reliability and Quality
Abstract

Flame spread over discrete solid fuels has been of key research interest in the past few decades. Most studies considered an array of discrete fuels separated by air gaps or heat-insulating inert materials. The effects of heat loss due to the discrete configuration are not well understood. The present study aims to bridge this knowledge gap. A series of experiments are performed using a vertical array of thin discrete fuels separated by heat-absorbing inert materials of different thicknesses. For comparisons, experiments are also performed using discrete fuels separated by air gaps and using continuous fuel. The flame base spread rate is found to be generally higher in discrete fuel than in continuous fuel configurations, due to a reduced fuel load per unit length. It is also found that the air and inert gaps have opposite effects on the solid burning rates. The air gaps break the no-slip boundary, allowing the laterally entrained buoyancy flow (normal to the sample surface) to push the flame closer to the samples. This leads to an enhanced heat flux on the sample surface and an increased solid burning rate. On the other hand, the inert materials retain the flow boundary profile and act as a heat sink during flame spread, thereby reducing the solid burning rate. As the inert thickness increases, flame spread rate and solid burning rate decrease. Based on these observations, an existing model for flame spread rate is updated by incorporating the heat-absorbing effects of the gaps. The correlation is validated using the experimental data.

Published
2023
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84. Loperamide Therapy for Acute Diarrhea in Children: Systematic Review and Meta-Analysis

Author

Li, Su-Ting T, Grossman, David C, and Cummings, Peter

Subjects
Clinical Research, Pediatric, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Age Factors, Child, Child, Preschool, Dehydration, Diarrhea, Humans, Infant, Loperamide, Models, Statistical, Placebos, Randomized Controlled Trials as Topic, Sensitivity and Specificity, Time Factors, Treatment Outcome, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundLoperamide is widely used in adults for acute diarrhea. However, its use in children has been discouraged by the World Health Organization and the American Academy of Pediatrics owing to concerns over safety and efficacy in young children.Methods and findingsTo assess the efficacy and adverse effects of loperamide compared with placebo for acute diarrhea in children, we reviewed Medline, EMBase, the Cochrane Central Register of Controlled Trials, and bibliographies of known clinical trials and of review articles, and we also interviewed key investigators in the field. We undertook a systematic review and meta-analysis of randomized controlled trials of children younger than 12 y of age with acute diarrhea, comparing loperamide with placebo. Included trials reported data on diarrhea duration or severity, or provided data on adverse effects. Compared with patients who received placebo, patients allocated to loperamide were less likely to continue to have diarrhea at 24 h (prevalence ratio 0.66, 95% confidence interval [CI]: 0.57 to 0.78), had a shorter duration of diarrhea by 0.8 d (95% CI: 0.7 to 0.9 d), and had a lower count of stools at 24 h (0.84, 95% CI: 0.77 to 0.92). Results were similar when random-effects summaries were estimated. Serious adverse events, defined as ileus, lethargy, or death, were reported in eight out of 927 children allocated to loperamide (0.9%, 95% CI: 0.4% to 1.7%). Serious adverse events were not reported in any of the 764 children allocated to placebo (0%, 95% CI: 0% to 0.5%). Among the children allocated to loperamide, serious adverse events were reported only among children younger than 3 y.ConclusionsIn children who are younger than 3 y, malnourished, moderately or severely dehydrated, systemically ill, or have bloody diarrhea, adverse events outweigh benefits even at doses

Published
2007

88. Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo

Author

Smith, Elisheva, Meyerrose, Todd E, Kohler, Thomas, Namdar-Attar, Malka, Bab, Natti, Lahat, Olga, Noh, Tommy, Li, Jingjing, Karaman, Mazen W, Hacia, Joseph G, Chen, Ting T, Nolta, Jan A, Müller, Ralph, Bab, Itai, and Frenkel, Baruch

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Animals, Bone and Bones, Codon, Initiator, Female, Genome, Histones, Humans, Male, Mice, Mice, Transgenic, Nucleotides, Osteogenesis, Protein Biosynthesis, RNA, Messenger, Radiography, Ribosomes, Cuticle, cracking, epidermis, fruit growth, Lycopersicon esculentum, plant biomechanics, ripening, stiffening, tomato, Environmental Sciences, Information and Computing Sciences, Developmental Biology, Biological sciences, Chemical sciences, Environmental sciences
Abstract

Like alternative splicing, leaky ribosomal scanning (LRS), which occurs at suboptimal translational initiation codons, increases the physiological flexibility of the genome by allowing alternative translation. Comprehensive analysis of 22 208 human mRNAs indicates that, although the most important positions relative to the first nucleotide of the initiation codon, -3 and +4, are usually such that support initiation (A-3 = 42%, G-3 = 36% and G+4 = 47%), only 37.4% of the genes adhere to the purine (R)-3/G+4 rule at both positions simultaneously, suggesting that LRS may occur in some of the remaining (62.6%) genes. Moreover, 12.5% of the genes lack both R-3 and G+4, potentially leading to sLRS. Compared with 11 genes known to undergo LRS, 10 genes with experimental evidence for high fidelity A+1T+2G+3 initiation codons adhered much more strongly to the R-3/G+4 rule. Among the intron-less histone genes, only the H3 genes adhere to the R-3/G+4 rule, while the H1, H2A, H2B and H4 genes usually lack either R-3 or G+4. To address in vivo the significance of the previously described LRS of H4 mRNAs, which results in alternative translation of the osteogenic growth peptide, transgenic mice were engineered that ubiquitously and constitutively express a mutant H4 mRNA with an A+1T+1 mutation. These transgenic mice, in particular the females, have a high bone mass phenotype, attributable to increased bone formation. These data suggest that many genes may fulfill cryptic functions by LRS.

Published
2005

93. Identification and functional characterization of WNT5 in the ovarian maturation of Exopalaemon carinicauda (Holthuis, 1950) (Caridea, Palaemonidae)

Author

Xiao F. Lai, Ting T. Shi, Hao Chen, Shan R. Shen, Huan Gao, and Ge T. Wu

Subjects
Animal Science and Zoology, Aquatic Science
Abstract

The Wnt family, the ligand of the Wnt signal pathway, is highly conserved and plays an important role in various cellular processes including reproduction and development. In this study, wnt5 was cloned from the ridgetail white prawn Exopalaemon carinicauda (Ec-wnt5) and its function in ovarian maturation was investigated. The results showed that the Ec-wnt5 cDNA was 2422 bp, including an ORF with 1116 bp encoding a polypeptide with 371 amino acids. Ec-WNT5 had the highest homology with WNT5 from Penaeus vannamei (93.1%). Ec-wnt5 was expressed in 9 tissues with the most expression in ovary and increased significantly () along with ovarian maturation, while decreased significantly () with vitellogenin and cathepsin L in E. carinicauda ovary post Ec-wnt5 RNA interference. All gonadosmatic indices of the RNAi group were significantly lower than those of the control (). The results suggest that Ec-WNT5 might be the key member of the Wnt family involved in ovarian maturation.

Published
2022
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100. The Early Effects of the Coronavirus Disease-19 Pandemic on Pediatric Resident Education: A National Assessment

Author

Monique M. Naifeh, Michelle D. Stevenson, Erika L. Abramson, Christopher E. Aston, Ryan M. Combs, Hallie R. Decker, and Su-Ting T. Li

Subjects
Pediatric, residency education, Prevention, Internship and Residency, COVID-19, Pediatrics, Competency-Based Education, United States, Education, Coronavirus disease-19, Quality Education, Paediatrics and Reproductive Medicine, Medical, Surveys and Questionnaires, competency-based medical education, Pediatrics, Perinatology and Child Health, Humans, Graduate, Child, Pandemics
Abstract

PurposeResidency programs must ensure resident competence for independent practice. The coronavirus disease-19 (COVID-19) pandemic disrupted health care delivery, impacting pediatric residencies. This study examines the impact on pediatric resident education.MethodsThe authors conducted a mixed methods national survey of pediatric residency program directors (PDs) from May 2020 to July 2020. Data analysis included descriptive statistics, chi-square, and Wilcoxon rank sum tests. Multivariable modeling identified factors associated with resident preparation for more senior roles. Thematic analysis was performed on open-ended questions about PD COVID-19 pandemic recommendations to peers, Accreditation Council for Graduate Medical Education and American Board of Pediatrics.ResultsResponse rate was 55% (110/199). PDs reported the COVID-19 pandemic negatively affected inpatient (n=86, 78.2%), and outpatient education (n=104, 94.5%), procedural competence (n=64; 58.2%), and resident preparation for more senior roles (n=50, 45.5%). In bivariate analyses, increasingly negative impacts on inpatient and outpatient education were associated with an increasingly negative impact on resident preparation for more senior roles (P=.03, P=.008), these relationships held true in multivariable analysis. Qualitative analysis identified 4 themes from PD recommendations: 1) Clear communication from governing bodies and other leaders; 2) Flexibility within programs and from governing bodies; 3) Clinical exposure is key for competency development; 4) Online platforms are important for education, communication, and support.ConclusionsThe COVID-19 pandemic negatively impacted inpatient and outpatient education. When these were more negatively impacted, resident preparation for more senior roles was worse, highlighting the importance of competency based medical education to tailor experiences ensuring each resident is competent for independent practice.

Published
2023

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