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52. Reporting of patient safety incidents in minimally invasive thoracic surgery: a national registered thoracic surgeons experience for improvement of patient safety

Author

Bottet, Benjamin, primary, Rivera, Caroline, additional, Dahan, Marcel, additional, Falcoz, Pierre-Emmanuel, additional, Jaillard, Sophie, additional, Baste, Jean-Marc, additional, Seguin-Givelet, Agathe, additional, de la Tour, Richard Bertrand, additional, Bellenot, Francois, additional, Rind, Alain, additional, Gossot, Dominique, additional, Thomas, Pascal-Alexandre, additional, and D’Journo, Xavier Benoit, additional

Published
2022
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56. Benignant and malignant epidemiology among surgical resections for suspicious solitary lung cancer without preoperative tissue diagnosis.

Author

Armand, Elsa, Boulate, David, Fourdrain, Alex, Nguyen, Ngoc-Anh-Thu, Resseguier, Noémie, Brioude, Geoffrey, Trousse, Delphine, Doddoli, Christophe, D'journo, Xavier-Benoit, and Thomas, Pascal-Alexandre

Subjects
SURGICAL excision, LUNG cancer, EPIDEMIOLOGY, DATABASES, LOGISTIC regression analysis
Abstract

Open in new tab Download slide OBJECTIVES The aim of this study was to describe the epidemiology of patients undergoing diagnostic and/or curative surgical pulmonary resections for lung opacities suspected of being localized primary lung cancers without preoperative tissue confirmation. METHODS We performed a single-centre retrospective study of a prospectively implemented institutional database of all patients who underwent pulmonary resection between January 2010 and December 2020. Patients were selected when surgery complied with the Fleischner society guidelines. We performed a multivariable logistic regression to determine the preoperative variables associated with malignancy. RESULTS Among 1392 patients, 213 (15.3%) had a final diagnosis of benignancy. We quantified futile parenchymal resections in 29 (2.1%) patients defined by an anatomical resection of >2 lung segments for benign lesions that did not modified the clinical management. Compared with patients with malignancies, patients with benignancies were younger (57.5 vs 63.9 years, P  < 0.001), had lower preoperative risk profile (thoracoscore 0.4 vs 2.1, P  < 0.001), had a higher proportion of wedge resection (50.7% vs 12.2%, P  < 0.01) and experienced a lower burden of postoperative complication (Clavien–Dindo IV or V, 0.4% vs 5.6%, P  < 0.001). Preoperative independent variables associated with malignancy were (adjusted odd ratio [95% confident interval]) age 1.02 [1.00; 1.04], smoking (year-pack) 1.005 (1.00; 1.01), history of cardiovascular disease 2.06 [1.30; 3.30], history of controlled cancer 2.74 [1.30; 6.88] and clinical N involvement 4.20 [1.11; 37.44]. CONCLUSIONS Futile parenchymal lung resection for suspicious opacities without preoperative tissue diagnosis is rare (2.1%) while surgery for benign lesions represented 15.3% and has a satisfactory safety profile with very low postoperative morbi-mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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58. Central Nervous System Metastases in Thymic Epithelial Tumors: A Brief Report of Real-World Insight From RYTHMIC

Author

Benitez, Jose Carlos, Boucher, Marie-Ève, Dansin, Eric, Kerjouan, Mallorie, Bigay-Game, L., Pichon, Eric, Thillays, François, Falcoz, Pierre-Emmanuel, Lyubimova, Svetlana, Oulkhouir, Youssef, Calcagno, Fabien, Thiberville, Luc, Clément-Duchêne, Christelle, Westeel, Virginie, Missy, Pascale, Thomas, Pascal-Alexandre, Maury, Jean-Michel, Molina, Thierry, Girard, Nicolas, and Besse, Benjamin

Published
2021
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59. Extracorporeal life support as a bridge to pulmonary retransplantation: prognostic factors for survival in a multicentre cohort analysis

Author

Inci, Ilhan, primary, Ehrsam, Jonas Peter, additional, Van Raemdonck, Dirk, additional, Ceulemans, Laurens Joseph, additional, Krüger, Thorsten, additional, Koutsokera, Angela, additional, Schiavon, Marco, additional, Faccioli, Eleonora, additional, Nosotti, Mario, additional, Rosso, Lorenzo, additional, D’Ovidio, Frank, additional, Leiva-Juarez, Miguel, additional, Aigner, Clemens, additional, Slama, Alexis, additional, Saleh, Waleed, additional, Alkattan, Khaled Manaa, additional, Thomas, Pascal Alexandre, additional, Brioude, Geoffrey, additional, Benazzo, Alberto, additional, and Hoetzenecker, Konrad, additional

Published
2021
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60. Surgical resection of Masaoka stage III thymic epithelial tumours with great vessels involvement: a retrospective multicentric analysis from the European Society of Thoracic Surgeons thymic database.

Author

Mendogni, Paolo, Toker, Alper, Moser, Bernhard, Trancho, Florentino Hernando, Aigner, Clemens, Bravio, Ivan Gomes, Novoa, Nuria Maria, Molins, Laureano, Costardi, Lorena, Voltolini, Luca, Ardò, Nicoletta Pia, Verdonck, Bram, Ampollini, Luca, Zisis, Charlambos, Barmin, Vitaly, Enyedi, Attila, Ruffini, Enrico, Raemdonck, Dirk Van, Thomas, Pascal-Alexandre, and Weder, Walter

Subjects
THYMECTOMY, SURGICAL excision, VENA cava superior, BRACHIOCEPHALIC veins, TUMOR surgery, RETROSPECTIVE studies
Abstract

Open in new tab Download slide OBJECTIVES The aim of this study was to analyse the outcomes of an international cohort of patients affected by Masaoka stage III thymic epithelial tumours with vascular involvement and treated by surgery. METHODS Study design was the observational multicentre retrospective cohort study. Data were extracted from the European Society of Thoracic Surgeons thymic database; additional variables were collected. Inclusion criteria were as follows: stage III (Masaoka–Koga) thymic epithelial tumours; surgery with radical intention; clinical or pathological great vessels involvement; and radiologically suspected or diagnosed intraoperatively. Outcome items were analysed. RESULTS Sixty-five patients submitted to surgery from 2001 to 2017 fulfilled inclusion criteria. Thymoma and thymic carcinoma patients did not differ for demographics and clinical characteristics. The majority of great vessel treated were superior vena cava or innominate veins (72.3%). Eleven patients (16.9%) had postoperative cardiopulmonary complications; vascular stenosis was observed in 3 patients (4.6%). The multivariable Cox analysis for disease-free survival showed an increased hazard of recurrence for thymic carcinoma (hazard ratio = 3.59; 95% confidence interval: 1.66–7.78, P = 0.001). The 1-, 3-, 5- and 10-year overall survival rates were 0.86, 0.84, 0.81, and 0.53, respectively. There was no significant difference in overall survival according to resection status or between thymoma and thimic carcinoma. The univariable Cox regression model did not show an increased hazard of death for myasthenic patients considering all resection status and for patients who received neoadjuvant therapy. CONCLUSIONS We observed that clinical outcomes of patients treated for stage III thymic epithelial tumours with vascular involvement are satisfactory suggesting to increase the confidence in dealing with these complex surgeries. Complete resection should be achieved, even though extensive vascular reconstructions are required. [ABSTRACT FROM AUTHOR]

Published
2022
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61. Surgical resection of Masaoka stage III thymic epithelial tumours with great vessels involvement: a retrospective multicentric analysis from the European Society of Thoracic Surgeons thymic database

Author

Mendogni, Paolo, Toker, Alper, Moser, Bernhard, Trancho, Florentino Hernando, Aigner, Clemens, Bravio, Ivan Gomes, Novoa, Nuria Maria, Molins, Laureano, Costardi, Lorena, Voltolini, Luca, Ardò, Nicoletta Pia, Verdonck, Bram, Ampollini, Luca, Zisis, Charlambos, Barmin, Vitaly, Enyedi, Attila, Ruffini, Enrico, Van Raemdonck, Dirk, Thomas, Pascal-Alexandre, Weder, Walter, Rocco, Gaetano, Brunelli, Alessandro, Detterbeck, Frank C, Venuta, Federico, Falcoz, Pierre-Emmanuel, Tosi, Davide, Bonitta, Gianluca, Nosotti, Mario, Ozkan, Berker, Cımenoglu, Berk, Thanner, Jürgen, Olivero, Carlos Fraile, Alvarado, Rodriguez, Boada, Marc, Bongiolatti, Stefano, Sollitto, Francesco, Van Schil, Paul, Bocchialini, Giovanni, Brioude, Geoffrey, and European Association of Thoracic Surgeons (ESTS) Thymic Working Group

Subjects
Pulmonary and Respiratory Medicine, Surgeons, recurrence, Vena Cava, Superior, Thymoma, great vessels, survival, thymectomy, thymic tumours, thymoma, Medizin, General Medicine, Thymus Neoplasms, Humans, Surgery, Human medicine, Neoplasms, Glandular and Epithelial, Cardiology and Cardiovascular Medicine, Neoplasm Staging, Retrospective Studies
Abstract

OBJECTIVES The aim of this study was to analyse the outcomes of an international cohort of patients affected by Masaoka stage III thymic epithelial tumours with vascular involvement and treated by surgery. METHODS Study design was the observational multicentre retrospective cohort study. Data were extracted from the European Society of Thoracic Surgeons thymic database; additional variables were collected. Inclusion criteria were as follows: stage III (Masaoka–Koga) thymic epithelial tumours; surgery with radical intention; clinical or pathological great vessels involvement; and radiologically suspected or diagnosed intraoperatively. Outcome items were analysed. RESULTS Sixty-five patients submitted to surgery from 2001 to 2017 fulfilled inclusion criteria. Thymoma and thymic carcinoma patients did not differ for demographics and clinical characteristics. The majority of great vessel treated were superior vena cava or innominate veins (72.3%). Eleven patients (16.9%) had postoperative cardiopulmonary complications; vascular stenosis was observed in 3 patients (4.6%). The multivariable Cox analysis for disease-free survival showed an increased hazard of recurrence for thymic carcinoma (hazard ratio = 3.59; 95% confidence interval: 1.66–7.78, P = 0.001). The 1-, 3-, 5- and 10-year overall survival rates were 0.86, 0.84, 0.81, and 0.53, respectively. There was no significant difference in overall survival according to resection status or between thymoma and thimic carcinoma. The univariable Cox regression model did not show an increased hazard of death for myasthenic patients considering all resection status and for patients who received neoadjuvant therapy. CONCLUSIONS We observed that clinical outcomes of patients treated for stage III thymic epithelial tumours with vascular involvement are satisfactory suggesting to increase the confidence in dealing with these complex surgeries. Complete resection should be achieved, even though extensive vascular reconstructions are required.

Published
2021

62. The Reality of Lung Cancer Paradox: The Impact of Body Mass Index on Long-Term Survival of Resected Lung Cancer. A French Nationwide Analysis from the Epithor Database

Author

Alifano, Marco, primary, Daffré, Elisa, additional, Iannelli, Antonio, additional, Brouchet, Laurent, additional, Falcoz, Pierre Emmanuel, additional, Le Pimpec Barthes, Françoise, additional, Bernard, Alain, additional, Pages, Pierre Benoit, additional, Thomas, Pascal Alexandre, additional, Dahan, Marcel, additional, and Porcher, Raphael, additional

Published
2021
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63. Corrigendum to ‘Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study’

Author

Guerrera, Francesco, primary, Falcoz, Pierre Emmanuel, additional, Moser, Bernhard, additional, van Raemdonck, Dirk, additional, Bille, Andrea, additional, Toker, Alper, additional, Spaggiari, Lorenzo, additional, Ampollini, Luca, additional, Filippini, Claudia, additional, Thomas, Pascal Alexandre, additional, Verdonck, Bram, additional, Mendogni, Paolo, additional, Aigner, Clemens, additional, Voltolini, Luca, additional, Novoa, Nuria, additional, Patella, Miriam, additional, Mantovani, Sara, additional, Bravio, Ivan Gomes, additional, Zisis, Charalambos, additional, Guirao, Angela, additional, Londero, Francesco, additional, Congregado, Miguel, additional, Rocco, Gaetano, additional, Pont, Bert Du, additional, Martucci, Nicola, additional, Esch, Matthias, additional, Brunelli, Alessandro, additional, Detterbeck, Frank C, additional, Venuta, Federico, additional, Weder, Walter, additional, Ruffini, Enrico, additional, Klepetko, Walter, additional, Olland, Anne, additional, DuPont, Bert, additional, Nonaka, Daisuke, additional, Ozkan, Berker, additional, Lo Iacono, Giorgio, additional, Braggio, Cesare, additional, Filosso, Pier Luigi, additional, Brioude, Geoffrey, additional, van Schil, Paul, additional, Nosotti, Mario, additional, Valdivia, Daniel, additional, Bongiolatti, Stefano, additional, Inci, Ilhan, additional, Dimitra, Rontogianni, additional, Sànchez, David, additional, Grossi, William, additional, Moreno-Merino, Sergio, additional, and Teschner, Martin, additional

Published
2021
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64. Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis.

Author

Lococo, Filippo, Nachira, Dania, Chiappetta, Marco, Evangelista, Jessica, Falcoz, Pierre Emmanuel, Ruffini, Enrico, Van Schil, Paul, Scarci, Marco, Furàk, Jòzsef, Sollitto, Francesco, Guerrera, Francesco, Spaggiari, Lorenzo, Aigner, Clemens, Evangelia, Liverakou, Billè, Andrea, Moser, Bernhard, Thomas, Pascal Alexandre, Liberman, Moishe, Boubia, Souheil, and Campisi, Alessio

Subjects
MYASTHENIA gravis, THYMECTOMY, CARCINOMA, RADIOTHERAPY, EPITHELIAL tumors, MUSCLE weakness, SURVIVAL rate, DATABASES
Abstract

Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II–III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG–TCs 78% vs. 50% in MG–TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients. [ABSTRACT FROM AUTHOR]

Published
2022
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65. Outcomes of thymic epithelial tumors (TETs) with pleural metastases: Real-world insight from RYTHMIC.

Author

Maury, Jean-Michel, primary, Benitez, Jose Carlos, additional, Boucher, Marie Eve, additional, Dansin, Eric, additional, Kerjouan, Mallorie, additional, Bigay-Game, Laurence, additional, Pichon, Eric, additional, Thillays, Francois, additional, Falcoz, Pierre-Emmanuel, additional, Svetlana, Lyubimova, additional, Oulkhouir, Youssef, additional, Fabien, Calcagno, additional, Thiberville, Luc, additional, Clément Duchene, Christelle, additional, Westeel, Virginie, additional, Missy, Pascale, additional, Thomas, Pascal Alexandre, additional, Molina, Thierry, additional, Girard, Nicolas, additional, and Besse, Benjamin, additional

Published
2021
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68. Post-Operative Radiotherapy (PORT) Versus No PORT in Patients With Completely Resected Non-Small Cell Lung Cancer and Proven Mediastinal N2 Involvement: An Open Label Randomised Phase 3 Superiority Trial (Lung ART (IFCT-0503, UK NCRI, SAKK))

Author

Le Pechoux, Cecile, primary, Pourel, Nicolas, additional, Barlesi, Fabrice, additional, Lerouge, Delphine, additional, Antoni, Delphine, additional, Lamezec, Bruno, additional, Nestle, Ursula, additional, Boisselier, Pierre, additional, Dansin, Eric, additional, Paumier, Amaury, additional, Peignaux, Karine, additional, Thillays, François, additional, Zalcman, Gerard, additional, Madelaine, Jeannick, additional, Pichon, Eric, additional, Larrouy, Anne, additional, Lavole, Armelle, additional, Argo-Leignel, Delphine, additional, Derollez, Marc, additional, Faivre-Finn, Corinne, additional, Hatton, Matthew Q., additional, Riesterer, Oliver, additional, Bouvier-Morel, Emilie, additional, Dunant, Ariane, additional, Edwards, John, additional, Thomas, Pascal Alexandre, additional, Mercier, Olaf, additional, and Bardet, Aurelie, additional

Published
2021
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69. Lung Cancer in France

Author

Pujol, Jean-Louis, primary, Thomas, Pascal-Alexandre, additional, Giraud, Philippe, additional, Denis, Marc G., additional, Tretarre, Brigitte, additional, Roch, Benoît, additional, and Bommart, Sebastien, additional

Published
2021
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70. Additional file 1 of Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Author

Coiffard, Benjamin, Prud’Homme, Eloi, Hraiech, Sami, Cassir, Nadim, Pavec, Jérôme Le, Kessler, Romain, Meloni, Federica, Leone, Marc, Thomas, Pascal Alexandre, Reynaud-Gaubert, Martine, and Papazian, Laurent

Subjects
surgical procedures, operative, respiratory system, respiratory tract diseases
Abstract

Additional file 1. Survey sent to the lung transplantation centers.

Published
2020
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71. Lymph node biopsy specimens and diagnosis of cat-scratch disease

Author

Rolain, Jean-Marc, Lepidi, Hubert, Zanaret, Michel, Triglia, Jean-Michel, Michel, Gerard, Thomas, Pascal-Alexandre, Texereau, Michele, Stein, Andreas, Romaru, Anette, Eb, Francois, and Raoult, Didier

Subjects
Cat-scratch disease -- Research, Cat-scratch disease -- Diagnosis, Cat-scratch disease -- Health aspects, Lymphadenopathy -- Research, Lymphadenopathy -- Diagnosis, Lymphadenopathy -- Causes of, Lymph nodes -- Biopsy, Lymph nodes -- Research
Abstract

We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents [...]

Published
2006

72. Unplanned readmission and survival after video-assisted thoracic surgery and open thoracotomy in patients with non-small-cell lung cancer: a 12-month nationwide cohort study

Author

Bouabdallah, Ilies, primary, Pauly, Vanessa, additional, Viprey, Marie, additional, Orleans, Veronica, additional, Fond, Guillaume, additional, Auquier, Pascal, additional, D'Journo, Xavier Benoit, additional, Boyer, Laurent, additional, and Thomas, Pascal Alexandre, additional

Published
2020
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73. Mathematical modeling of peripheral blood neutrophil kinetics to predict CLAD after lung transplantation

Author

Coiffard, Benjamin, primary, Reynaud-Gaubert, Martine, additional, Rey, Jean-Baptiste, additional, Cousin, Elissa, additional, Grosdidier, Charlotte, additional, Nicolino-Brunet, Corinne, additional, Dignat-George, Françoise, additional, Papazian, Laurent, additional, Thomas, Pascal Alexandre, additional, Barbolosi, Dominique, additional, and Serre, Raphaël, additional

Published
2020
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74. Extracorporeal life support as a bridge to pulmonary retransplantation: prognostic factors for survival in a multicentre cohort analysis.

Author

Inci, Ilhan, Ehrsam, Jonas Peter, Raemdonck, Dirk Van, Ceulemans, Laurens Joseph, Krüger, Thorsten, Koutsokera, Angela, Schiavon, Marco, Faccioli, Eleonora, Nosotti, Mario, Rosso, Lorenzo, D'Ovidio, Frank, Leiva-Juarez, Miguel, Aigner, Clemens, Slama, Alexis, Saleh, Waleed, Alkattan, Khaled Manaa, Thomas, Pascal Alexandre, Brioude, Geoffrey, Benazzo, Alberto, and Hoetzenecker, Konrad

Subjects
EXTRACORPOREAL membrane oxygenation, TRANSPLANTATION of organs, tissues, etc., PROGNOSIS, COHORT analysis, MORTALITY risk factors, REGRESSION analysis, OVERALL survival
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Pulmonary retransplant (ReTx) is considered a controversial procedure. Despite literature reporting outcomes following ReTx, limited data exist in recipients bridged to their ReTx on extracorporeal life support (ECLS). The goal of this study was to investigate the outcomes of recipients bridged to a first-time ReTx by ECLS. METHODS We performed a retrospective multicentre cohort analysis from 10 centres in Europe, Asia and North America. The primary outcome was overall survival. Risk factors were analysed using Cox regression models. RESULTS ECLS as a bridge to a first-time ReTx was performed in 50 recipients (ECLS-ReTx). During the study period, 210 recipients underwent a first-time ReTx without bridging on ECLS (regular-ReTx) and 4959 recipients had a primary pulmonary transplant (index-Tx). The overall 1-year (55%) and 5-year (29%) survival was significantly worse for the ECLS-ReTx group. Compared to the index-Tx group, the mortality risk was significantly higher after ECLS-ReTx [hazard ratio 2.76 (95% confidence interval 1.94–3.91); P  < 0.001] and regular-ReTx [hazard ratio 1.65 (95% confidence interval 1.36–2); P  < 0.001]. In multivariable analysis, recipient age ≥35 years, time interval <1 year from index-Tx, primary graft dysfunction as transplant indication, venoarterial-extracorporeal membrane oxygenation and Zurich donor score ≥4 points were significant risk factors for mortality in ECLS-ReTx recipients. CONCLUSIONS Recipients for ECLS-ReTx should be carefully selected. Risk factors, such as recipient age, intertransplant interval, primary graft dysfunction as transplant indication and type of ECLS should be kept in mind before bridging these patients on ECLS to ReTx. [ABSTRACT FROM AUTHOR]

Published
2022
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75. Prevalence of autoimmune diseases in thymic epithelial tumors (TET) insights from RYTHMIC.

Author

Benitez, Jose Carlos, primary, Boucher, Marie Eve, additional, Dansin, Eric, additional, Kerjouan, Mallorie, additional, Mazieres, Julien, additional, Pichon, Eric, additional, Thillays, Francois, additional, Falcoz, Pierre-Emmanuel, additional, Roch, Benoit, additional, Oulkhouir, Youssef, additional, Fabien, Calcagno, additional, Thiberville, Luc, additional, Clément Duchene, Christelle, additional, Morin, Franck, additional, Missy, Pascale, additional, Thomas, Pascal Alexandre, additional, Maury, Jean-Michel, additional, Molina, Thierry, additional, Girard, Nicolas, additional, and Besse, Benjamin, additional

Published
2020
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77. Lung Ultrasound Findings in the Postanesthesia Care Unit Are Associated With Outcome After Major Surgery: A Prospective Observational Study in a High-Risk Cohort

Author

Zieleskiewicz, Laurent, primary, Papinko, Mickael, additional, Lopez, Alexandre, additional, Baldovini, Alice, additional, Fiocchi, David, additional, Meresse, Zoe, additional, Boussuges, Alain, additional, Thomas, Pascal Alexandre, additional, Berdah, Stephane, additional, Creagh-Brown, Ben, additional, Bouhemad, Belaid, additional, Futier, Emmanuel, additional, Resseguier, Noémie, additional, Antonini, François, additional, Duclos, Gary, additional, and Leone, Marc, additional

Published
2020
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78. Systemic lupus erythematosus associated with thymoma: A fifteen-year observational study in France

Author

Noël, Nicolas, primary, Le Roy, Audrey, additional, Hot, Arnaud, additional, Saadoun, David, additional, Lazaro, Estibaliz, additional, Lévesque, Hervé, additional, Le Gouellec, Noémie, additional, Meaux-Ruault, Nadine, additional, Nguyen, Thierry, additional, Costedoat-Chalumeau, Nathalie, additional, Amieux, Béatrice, additional, Fontana, Aurélie, additional, De Gennes, Christian, additional, Fulpin, Jean, additional, Thomas, Pascal-Alexandre, additional, Bluthgen, Maria-Virginia, additional, Besse, Benjamin, additional, and Lambotte, Olivier, additional

Published
2020
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79. HLA-H: Transcriptional Activity and HLA-E Mobilization

Author

Jordier, François, primary, Gras, Delphine, additional, De Grandis, Maria, additional, D'Journo, Xavier-Benoît, additional, Thomas, Pascal-Alexandre, additional, Chanez, Pascal, additional, Picard, Christophe, additional, Chiaroni, Jacques, additional, Paganini, Julien, additional, and Di Cristofaro, Julie, additional

Published
2020
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81. Screening and topical decolonization of preoperative nasal Staphylococcus aureus carriers to reduce the incidence of postoperative infections after lung cancer surgery: a propensity matched study

Author

Fourdrain, Alex, primary, Bouabdallah, Ilies, primary, Gust, Lucile, primary, Cassir, Nadim, primary, Brioude, Geoffrey, primary, Falcoz, Pierre-Emmanuel, primary, Alifano, Marco, primary, Le Rochais, Jean-Philippe, primary, D’Annoville, Thomas, primary, Trousse, Delphine, primary, Loundou, Anderson, primary, Leone, Marc, primary, Papazian, Laurent, primary, Thomas, Pascal Alexandre, primary, and D’Journo, Xavier Benoit, primary

Published
2019
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83. Adenocarcinoma of the oesophagogastric junction Siewert II: An oesophageal cancer better cured with total gastrectomy

Author

Voron, Thibault, primary, Gronnier, Caroline, additional, Pasquer, Arnaud, additional, Thereaux, Jeremie, additional, Gagniere, Johan, additional, Lebreton, Gil, additional, Meunier, Bernard, additional, Collet, Denis, additional, Piessen, Guillaume, additional, Paye, François, additional, Arnaud, Jean Pierre, additional, Balon, Jean Michel, additional, Bonnetain, Frank, additional, Borie, Frederic, additional, Brachet, Dorothée, additional, Brigand, Cécile, additional, Carrere, Nicolas, additional, D'Journo, Xavier Benoit, additional, Dechelotte, Pierre, additional, Delpero, Jean Robert, additional, Dhari, Abdenaceur, additional, Fabre, Sylvain, additional, Fernandez, Manuel, additional, Flamein, Renaud, additional, Gillet, Brigitte, additional, Glaise, Aude, additional, Glehen, Olivier, additional, Goéré, Diane, additional, Guilbert, Marie, additional, Guiramand, Jérôme, additional, Hebbar, Mohamed, additional, Huten, Noël, additional, Leteurtre, Emmanuelle, additional, Kraft, Kevin, additional, Louis, Damien, additional, Mabrut, Jean Yves, additional, Mathieu, Benjamin, additional, Michalak, Sophie, additional, Michot, Francis, additional, Millat, Bertrand, additional, Lefevre, Jeremie H., additional, Peschaud, Fédérique, additional, Pezet, Denis, additional, Pichot-Delahaye, Virginie, additional, Pocard, Marc, additional, Poisson, Ariane, additional, Prudhomme, Michel, additional, Regimbeau, Jean Marc, additional, Thiébot, Timothée, additional, Thomas, Pascal- Alexandre, additional, Tsilividis, Basile, additional, and Vandois, Florence, additional

Published
2019
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85. Impact of donor, recipient and matching on survival after high emergency lung transplantation in France

Author

Roussel, Arnaud, primary, Sage, Edouard, additional, Massard, Gilbert, additional, Thomas, Pascal-Alexandre, additional, Castier, Yves, additional, Fadel, Elie, additional, Le Pimpec-Barthes, Françoise, additional, Maury, Jean-Michel, additional, Jougon, Jacques, additional, Lacoste, Philippe, additional, Claustre, Johanna, additional, Dahan, Marcel, additional, Pirvu, Augustin, additional, Tissot, Adrien, additional, Thumerel, Matthieu, additional, Drevet, Gabrielle, additional, Pricopi, Ciprian, additional, Le Pavec, Jérôme, additional, Mal, Hervé, additional, D'Journo, Xavier-Benoit, additional, Kessler, Romain, additional, Roux, Antoine, additional, Dorent, Richard, additional, Thabut, Gabriel, additional, and Mordant, Pierre, additional

Published
2019
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86. Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study.

Author

Guerrera, Francesco, Falcoz, Pierre Emmanuel, Moser, Bernhard, Raemdonck, Dirk van, Bille', Andrea, Toker, Alper, Spaggiari, Lorenzo, Ampollini, Luca, Filippini, Claudia, Thomas, Pascal Alexandre, Verdonck, Bram, Mendogni, Paolo, Aigner, Clemens, Voltolini, Luca, Novoa, Nuria, Patella, Miriam, Mantovani, Sara, Bravio, Ivan Gomes, Zisis, Charalambos, and Guirao, Angela

Subjects
THYMECTOMY, MYASTHENIA gravis, THYMOMA, SURVIVAL rate, TUMOR surgery, OVERALL survival
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Resection of thymic tumours including the removal of both the tumour and the thymus gland (thymothymectomy; TT) is the procedure of choice and is recommended in most relevant articles in the literature. Nevertheless, in recent years, some authors have suggested that resection of the tumour (simple thymomectomy; ST) may suffice from an oncological standpoint in patients with early-stage thymoma who do not have myasthenia gravis (MG) (non-MG). The goal of our study was to compare the short- and long-term outcomes of ST versus TT in non-MG early-stage thymomas using the European Society of Thoracic Surgeons thymic database. METHODS A total of 498 non-MG patients with pathological stage I thymoma were included in the study. TT was performed in 466 (93.6%) of 498 patients who had surgery with curative intent; ST was done in 32 (6.4%). The completeness of resection, the rate of complications, the 30-day mortality, the overall recurrence and the freedom from recurrence were compared. We performed crude and propensity score-adjusted comparisons by surgical approach (ST vs TT). RESULTS TT showed the same rate of postoperative complications, 30-day mortality and postoperative length of stay as ST. The 5-year overall survival rate was 89% in the TT group and 55% in the ST group. The 5-year freedom from recurrence was 96% in the TT group and 79% in the ST group. CONCLUSION Patients with early-stage thymoma without MG who have a TT show significantly better freedom from recurrence than those who have an ST, without an increase in postoperative morbidity rate. [ABSTRACT FROM AUTHOR]

Published
2021
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87. Recurrence in complete responders after trimodality therapy in esophageal cancer

Author

Bouabdallah, Ilies, Thomas, Pascal Alexandre, D'Journo, Xavier Benoit, Benoit D’Journo, Xavier, Departement de chirurgie thoracique et des maladies de l'oesophage [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Hôpital Nord [CHU - APHM]-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], Pathological response, [SDV.CAN]Life Sciences [q-bio]/Cancer, 030204 cardiovascular system & hematology, Esophageal cancer, medicine.disease, 3. Good health, Editorial Commentary, 03 medical and health sciences, 0302 clinical medicine, Text mining, 030220 oncology & carcinogenesis, Internal medicine, Medicine, business, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Neoadjuvant chemoradiotherapy
Abstract

Complete pathological response (pCR) remains one of the most important prognostic factors of long-term survival in esophageal cancer (EC) and gastro-esophageal junction (GEJ) after trimodality treatment including neoadjuvant chemoradiotherapy (CRT) followed by surgery.

Published
2019

91. Unplanned readmission and survival after video-assisted thoracic surgery and open thoracotomy in patients with non-small-cell lung cancer: a 12-month nationwide cohort study.

Author

Bouabdallah, Ilies, Pauly, Vanessa, Viprey, Marie, Orleans, Veronica, Fond, Guillaume, Auquier, Pascal, D'Journo, Xavier Benoit, Boyer, Laurent, and Thomas, Pascal Alexandre

Subjects
VIDEO-assisted thoracic surgery, NON-small-cell lung carcinoma, PATIENT readmissions, PROPENSITY score matching, THORACOTOMY
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES To compare outcomes at 12 months between video-assisted thoracic surgery (VATS) and open thoracotomy (OT) in patients with non-small-cell lung cancer (NSCLC) using real-world evidence. METHODS We did a nationwide propensity-matched cohort study. We included all patients who had a diagnosis of NSCLC and who benefitted from lobectomy between 1 January 2015 and 31 December 2017. We divided this population into 2 groups (VATS and OT) and matched them using propensity scores based on patients' and hospitals' characteristics. Unplanned readmission, mortality, complications, length of stay and hospitalization costs within 12 months of follow-up were compared between the 2 groups. RESULTS A total of 13 027 patients from 180 hospitals were included, split into 6231 VATS (47.8%) and 6796 OT (52.2%). After propensity score matching (5617 patients in each group), VATS was not associated with a lower risk of unplanned readmission compared with OT [20.7% vs 21.9%, hazard ratio 1.03 (0.95–1.12)] during the 12-months follow-up. Unplanned readmissions at 90 days were mainly due to pulmonary complications (particularly pleural effusion and pneumonia) and were associated with higher mortality at 12 months (13.4% vs 2.7%, P  < 0.0001). CONCLUSIONS VATS and OT were both associated with high incidence of unplanned readmissions within 12 months, requiring a better identification of prognosticators of unplanned readmissions. Our study highlights the need to improve prevention, early diagnosis and treatment of pulmonary complications in patients with VATS and OT after discharge. These findings call for improving the dissemination of systematic perioperative care pathway including efficient pulmonary physiotherapy and rehabilitation. [ABSTRACT FROM AUTHOR]

Published
2021
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92. The European Society of Thoracic Surgeons (ESTS) lung neuroendocrine tumors (NETs) database

Author

Filosso, Pier Luigi, Falcoz, Pierre Emmanuel, Solidoro, Paolo, Pellicano, Danilo, Passani, Stefano, Guerrera, Francesco, Ruffini, Enrico, Casadio, Caterina, Rena, Ottavio, Casado, Paula Moreno, Alvarez, Antonio, Sagan, Dariusz, Carbognani, Paolo, Ampollini, Luca, Asadi, Nizar, Stella, Federico, Nosotti, Mario, Santambrogio, Luigi, Thomas, Pascal Alexandre, Gust, Lucile, Pompili, Cecilia, Brunelli, Alessandro, Margaritora, Stefano, Chiappetta, Marco, Roesel, Christian, Rendina, Erino Angelo, Maurizi, Giulio, Larocca, Valentina, Ardissone, Francesco, Travis, William D., Sarkaria, Inderpal, and Rocco, Gaetano

Subjects
Pulmonary and Respiratory Medicine, Medizin, Review Article, 030204 cardiovascular system & hematology, Neuroendocrine tumors, computer.software_genre, prospective database, Retrospective database, Retrospective data, lung, 03 medical and health sciences, neuroendocrine tumors (NETs), outcome, retrospective database, 0302 clinical medicine, Medicine, Lung, Outcome, Database, business.industry, Prospective database, medicine.disease, Neuroendocrine Carcinomas, Clinical trial, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Neuroendocrine tumors (NETs), business, computer
Abstract

Histological characteristics and clinical behaviour define lung neuroendocrine tumors (NETs), which are classified into four groups: typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine carcinomas (LCNCs) and small-cell lung cancers (SCLCs). Historically, outcome and treatment of these rare neoplasms have been based on small, usually mono-institutional clinical series. Furthermore, their rarity makes quite impossible to design randomised clinical trial to compare different treatments especially in unusual clinical presentations. In 2012, the European Society of Thoracic Surgeons (ESTS) launched a new working-group, specifically dedicated to lung NETs, with the aim to develop modern knowledge on biology and behaviour of these tumors, and to disseminate it within the scientific community. A dedicated retrospective database was at first developed and sent to all the ESTS centres interested to this project. More than 2,000 operated NETs cases have been rapidly collected, and they represented the clinical substrate of several published scientific studies. The retrospective data collection intrinsic limitations in term of patients' selection and treatment, along with the problem of possible missing data, were the reasons why the ESTS NETs working-group decided in 2015 to design and promote a new prospective database, employing the official ESTS platform. The aim of this review paper is to report the ESTS Lung NETs working-group history and to explain the architecture and use of the lung NETs databases.

Published
2018

93. Radiology and artificial intelligence: An opportunity for our specialty

Author

D'Journo, Xavier Benoit, Falcoz, Pierre-Emmanuel, Alifano, Marco, Le Rochais, Jean-Philippe, D'Annoville, Thomas, Massard, Gilbert, Regnard, Jean Francois, Icard, Philippe, Marty-Ane, Charles, Trousse, Delphine, Doddoli, Christophe, Orsini, Bastien, Edouard, Sophie, Million, Matthieu, Lesavre, Nathalie, Loundou, Anderson, Baumstarck, Karine, Peyron, Florence, Honore, Stephane, Dizier, Stephanie, Charvet, Aude, Leone, Marc, Raoult, Didier, Papazian, Laurent, Thomas, Pascal Alexandre, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Paul Brousse, service de neuroradiologie [Paris], Hôpital Sainte-Anne, Service de chirurgie thoracique et cardio-vasculaire, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Université de Montpellier (UM), Microbes évolution phylogénie et infections (MEPHI), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Radiological and Ultrasound Technology, business.industry, [SDV]Life Sciences [q-bio], Specialty, MEDLINE, General Medicine, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Artificial Intelligence, 030220 oncology & carcinogenesis, Medicine, Radiology, Nuclear Medicine and imaging, Medical physics, business, Radiology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

94. Hernies hiatales après œsophagectomie. Étude francophone européenne multicentrique

Author

Gust, Lucile, Nafteux, Philippe, Allemann, Pierre, Tuech, Jean-Jacques, El Nakadi, Issam, Collet, Denis, Goere, Diane, Fabre, Jean-Michel, Meunier, Bernard, Dumont, Frédéric, Poncet, Gilles, Passot, Guillaume, Carrere, Nicolas, Mathonnet, Muriel, Lebreton, Gil, Theraux, Jérémie, Marchal, Frédéric, Porcheron, Jack, Thomas, Pascal-Alexandre, Piessen, Guillaume, and D’Journo, Xavier-Benoît

Subjects
Thoracic surgery, Esophagus, Surgery, complications
Abstract

JCTCV:22(1), Introduction: After esophagectomy, part of the viscera can migrate through the hiatus to surround the gastric tube, creating hiatal hernias (HH) which eventually lead to abdominal occlusion and bowel ischemia. Methods: This retrospective multicenter study investigated the diagnosis, surgical management and follow-up of HH after esophagectomy in French-speaking European departments. Results: From 2000 to 2016, 19 departments performed 6608 esophagectomies. During follow-up, 78 cases of HH (1.2%) required surgery. These were more frequent after the laparoscopic approach than after laparotomy (1.4% vs. 0.7%; p = 0.03). The appearance of HH occurred during early follow-up (≤90 days) for 17 patients (21.5%), 21 underwent surgery during the first year (26.6%) and 41 after the first year (51.9%), with 13, 13 and 17 urgent surgeries, respectively. The surgical approaches included laparotomy (n = 35, 45%), especially when bowel resection was needed, laparoscopy (n = 19, 24%), a thoracic approach (n = 13, 17%) or a thoracophrenolaparotomy (n = 11, 14%). Complications arose in 36 patients, with one death and 13 secondary surgeries (three for secondary HH). Eight patients presented with recurrent HH (between 6 days and 26 months). Conclusion: Development of HH after esophagectomy can have a wide range of presentations, and can lead to thoracic or abdominal complications requiring specialized management.

Published
2018
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97. Hiatal hernia after oesophagectomy: a large European survey

Author

Gust, Lucile, primary, Nafteux, Philippe, additional, Allemann, Pierre, additional, Tuech, Jean-Jacques, additional, El Nakadi, Issam, additional, Collet, Denis, additional, Goere, Diane, additional, Fabre, Jean-Michel, additional, Meunier, Bernard, additional, Dumont, Frédéric, additional, Poncet, Gilles, additional, Passot, Guillaume, additional, Carrere, Nicolas, additional, Mathonnet, Muriel, additional, Lebreton, Gil, additional, Theraux, Jérémie, additional, Marchal, Frédéric, additional, Barabino, Gabriele, additional, Thomas, Pascal-Alexandre, additional, Piessen, Guillaume, additional, and D’Journo, Xavier-Benoît, additional

Published
2018
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98. Sepsis is associated with lack of monocyte HLA-DR expression recovery without modulating T-cell reconstitution after lung transplantation

Author

Alingrin, Julie, primary, Coiffard, Benjamin, additional, Textoris, Julien, additional, Nicolino-Brunet, Corine, additional, Gossez, Morgane, additional, Jarrot, Pierre-André, additional, Dignat-George, Françoise, additional, Monneret, Guillaume, additional, Thomas, Pascal Alexandre, additional, Leone, Marc, additional, Reynaud-Gaubert, Martine, additional, and Papazian, Laurent, additional

Published
2018
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100. Integrating extended focused assessment with sonography for trauma (eFAST) in the initial assessment of severe trauma: Impact on the management of 756 patients

Author

Zieleskiewicz, Laurent, primary, Fresco, Raphaelle, additional, Duclos, Gary, additional, Antonini, François, additional, Mathieu, Calypso, additional, Medam, Sophie, additional, Vigne, Coralie, additional, Poirier, Marion, additional, Roche, Pierre-Hugues, additional, Bouzat, Pierre, additional, Kerbaul, François, additional, Scemama, Ugo, additional, Bège, Thierry, additional, Thomas, Pascal Alexandre, additional, Flecher, Xavier, additional, Hammad, Emmanuelle, additional, and Leone, Marc, additional

Published
2018
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