99 results on '"Thierauf-Emberger A"'
Search Results
52. Detection of the ethanol consumption markers ethyl glucuronide and ethyl sulfate in urine samples from inmates of two German prisons
- Author
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Thierauf-Emberger, Annette, Franz, Anette, Auwärter, Volker, and Huppertz, Laura M.
- Published
- 2016
- Full Text
- View/download PDF
53. Mechanical Trauma and Classification of Wounds
- Author
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Madea, Burkhard, primary, Pollak, Stefan, additional, Thierauf‐Emberger, Annette, additional, Henn, Veronique, additional, Meissner, Christoph, additional, Oehmichen, Manfred, additional, and Leth, Peter Mygind, additional
- Published
- 2022
- Full Text
- View/download PDF
54. Incomplete decapitation with exenteration of the brain in a motorcyclist run over by a semitrailer
- Author
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Vanessa Thoma, Dorothee Geisenberger, Dominik Schuldis, Andreas Lickert, Stefan Pollak, Annette Thierauf-Emberger, and Giorgia Franchetti
- Subjects
Issues, ethics and legal aspects ,Pathology and Forensic Medicine - Published
- 2023
55. Unvollendet gebliebener Versuch eines erweiterten Suizids durch Stromeinwirkung in der Badewanne
- Author
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Vanessa Thoma, Stefan Pollak, Annette Thierauf-Emberger, and Volker Auwärter
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03 medical and health sciences ,030505 public health ,0302 clinical medicine ,media_common.quotation_subject ,Art ,0305 other medical science ,Humanities ,030217 neurology & neurosurgery ,Pathology and Forensic Medicine ,media_common - Abstract
ZusammenfassungWährend sich heutzutage in westlichen Ländern erweiterte Suizide ganz überwiegend in (gescheiterten) Partnerbeziehungen ereignen, stellen Kindstötungen mit nachfolgendem Suizid eines Elternteils ein seltenes Ereignis dar. Vorgestellt wird der ungewöhnliche Fall eines versuchten Homizid-Suizides einer 36-jährigen Frau, die durch das Einbringen eines eingeschalteten Föhns in das Badewasser beabsichtigte, sich und ihre 7 Jahre alte Tochter zu töten. Während sich das Kind selbstständig aus der Wanne befreien und die Großeltern informieren konnte, wurde die Frau in benommenem Zustand von ihrem Vater vorgefunden. Beim Versuch, seine Tochter aus der Badewanne zu bergen, habe er einen Stromfluss verspürt. Bemerkenswerterweise haben alle 3 Personen ohne gesundheitlichen Schaden überlebt; sie wiesen keine Strommarken auf. Die ungewöhnliche Fallkonstellation, die elektrotechnischen Aspekte und die psychiatrische Vorgeschichte der Täterin, die zum Tatzeitpunkt unter dem Einfluss von Alkohol und eines sedierenden Mittels stand, werden unter Berücksichtigung der einschlägigen Literatur diskutiert.
- Published
- 2021
56. Differing sizes of bullet entrance holes in skin of the anterior and posterior trunk
- Author
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D. Geisenberger, M. Große Perdekamp, S. Pollak, A. Thierauf-Emberger, and V. Thoma
- Subjects
Firearms ,Forensic Ballistics ,Swine ,Animals ,Wounds, Gunshot ,Pathology and Forensic Medicine ,Skin - Abstract
The aim of the present study was to establish whether the size (diameter and area) of bullet entrance holes in skin varies between distant shots to the anterior and posterior trunk, respectively, when using the same ammunition (in concreto pistol cartridges 9 mm Luger). For that purpose, specimens of porcine skin from the belly region and the back were taken (10 samples each) and shot at from a distance of 1.6 m. The entrance holes were photo-documented under standardised conditions. After image processing for contrast enhancement, the maximum diameter and the area of each skin defect were measured automatically by means of an image analysis system. Both size parameters differed significantly depending on the body region affected. On the back with its comparatively thick dermis, the skin defects were considerably smaller than those on the ventral trunk where the corium is less thick. This difference can be explained by the fact that the elastic properties of skin are strongly determined by the connective tissue which is especially rich in fibres. The study results were consistent with the authors’ casework experience and support the assumption that the entrance site of gunshot wounds has a major influence on the size of the bullet hole in skin.
- Published
- 2022
57. Can PEth be Detected with a Cutoff of 20 ng/mL after Single Alcohol Consumption?
- Author
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Frederike Stöth, Ephraim Kotzerke, Annette Thierauf-Emberger, Wolfgang Weinmann, and Dominik Schuldis
- Subjects
Chemical Health and Safety ,Health, Toxicology and Mutagenesis ,Environmental Chemistry ,Toxicology ,Analytical Chemistry - Abstract
Phosphatidylethanol (PEth) can be determined in capillary blood collected as dried blood spots (DBS) and is a promising direct alcohol biomarker for the determination of drinking habits. Its use for abstinence monitoring needs to be evaluated. Studies with patients undergoing alcohol withdrawal have shown that the elimination of PEth can take up to 2 months. For the determination of PEth 16:0/18:1, a cutoff of 20 ng/mL has been agreed upon in the major US laboratories. However, it is not yet clear what minimum blood alcohol concentrations (BACs) have to be achieved by a single drinking episode to result in PEth concentrations above this cutoff after previous long-term abstinence. To determine whether low drinking amounts can result in a positive PEth concentration above 20 ng/mL, we recruited 12 participants (‘social’ drinkers). After 4 weeks of abstinence, alcohol was consumed at two separate drinking events with target BACs of 0.5 and 0.3 g/kg, resulting in maximum BACs in the ranges of 0.30–0.63 g/kg and 0.10–0.28 g/kg, respectively. Capillary blood was collected at different time points of the drinking experiment, and PEth was extracted from DBS and analyzed by liquid chromatography–tandem mass spectrometry. Despite drinking doses up to 0.58 g ethanol per kg body weight and reaching BACs of up to 0.63 g/kg, PEth 16:0/18:1 and PEth 16:0/18:2 could not be detected at or above the 20 ng/mL cutoff in any participant at any time after the drinking events. We conclude that after long-term abstinence the cutoff of 20 ng/mL for single alcohol consumption leading to BACs up to 0.63 g/kg is not exceeded.
- Published
- 2022
58. Influence of Gilbert’s syndrome on the formation of ethyl glucuronide
- Author
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Huppertz, Laura M., Gunsilius, Leonie, Lardi, Christelle, Weinmann, Wolfgang, and Thierauf-Emberger, Annette
- Published
- 2015
- Full Text
- View/download PDF
59. Penetrierende Kopfverletzung durch eine Nagelschraube: Überlegungen zur Unfallursache
- Author
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Thierauf-Emberger, A. and Pollak, S.
- Published
- 2014
- Full Text
- View/download PDF
60. Comparison of ethanol concentrations in the human brain determined by magnetic resonance spectroscopy and serum ethanol concentrations
- Author
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Annette Thierauf-Emberger, Judith Echle, Michael Dacko, and Thomas Lange
- Subjects
Serum ,Brain Chemistry ,Male ,0303 health sciences ,Magnetic Resonance Spectroscopy ,Ethanol ,Putamen ,Brain ,Correction ,Frontal Lobe ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Cerebellum ,Humans ,Original Article ,Blood Alcohol Content ,Occipital Lobe ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Aims Ethanol is a widespread substance that inherits desired effects, but also negative consequences with regard to DUI or battery. Where required, the ethanol concentration is usually determined in peripheral venous blood samples, while the brain is the target organ of the ethanol effects. The aim of this study with three participants was the determination of the ethanol concentration in functionally relevant regions of the brain and the comparison with serum ethanol concentrations. Design After the uptake of ethanol in a calculated amount, leading to a serum ethanol concentration of 0.99 g/L, the ethanol concentrations in the brain were directly analyzed by means of magnetic resonance spectroscopy on a 3 Tesla human MRI system and normalized to the water content. The measurement voxels were located in the occipital cortex, the cerebellum, the frontal cortex, and the putamen and successively examined. Intermittently blood samples were taken, and serum was analyzed for ethanol using HS-GC-FID. Findings and conclusions Ethanol concentrations in brain regions normalized to the water content were lower than the measured serum ethanol results and rather homogenous within the three participants and the various regions of the brain. The maximum ethanol concentration in the brain (normalized to water content) was 0.68 g/L. It was measured in the frontal cortex, in which the highest results were gained. The maximum serum concentration was 1.19 g/L. The course of the brain ethanol curve seems to be flatter than the one of the serum ethanol concentrations.
- Published
- 2020
61. Can PEth be Detected with a Cutoff of 20 ng/mL after Single Alcohol Consumption?
- Author
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Stöth, Frederike, Kotzerke, Ephraim, Thierauf-Emberger, Annette, Weinmann, Wolfgang, and Schuldis, Dominik
- Subjects
360 Soziale Probleme, Sozialdienste ,610 Medizin und Gesundheit - Abstract
Phosphatidylethanol (PEth) can be determined in capillary blood collected as dried blood spots (DBS) and is a promising direct alcohol biomarker for determination of drinking habits. Its use for abstinence monitoring needs to be evaluated. Studies with patients undergoing alcohol withdrawal have shown that elimination of PEth can take up to two months. For the determination of PEth 16:0/18:1, a cutoff of 20 ng/mL has been agreed upon in the major US laboratories. However, it is not yet clear what minimum blood alcohol concentrations (BACs) have to be achieved by a single drinking episode to result in PEth concentrations above this cutoff after previous long-term abstinence. To determine whether low drinking amounts can result in a positive PEth concentration above 20 ng/mL, we recruited 12 participants ("social" drinkers). After four weeks of abstinence, alcohol was consumed at two separate drinking events with target BACs of 0.5 and 0.3 g/kg, resulting in maximum BACs in the ranges of 0.30-0.63 g/kg and 0.10-0.28 g/kg, respectively. Capillary blood was collected at different time points of the drinking experiment and PEth was extracted from dried blood spots (DBS) and analyzed by liquid chromatography-tandem mass spectrometry. Despite drinking doses up to 0.58 g ethanol per kg body weight and reaching BACs of up to 0.63 g/kg, PEth 16:0/18:1 and PEth 16:0/18:2 could not be detected at or above the 20 ng/mL cutoff in any participant at any time after the drinking events. We conclude that after long-term abstinence the cutoff of 20 ng/ml for single alcohol consumption leading to blood alcohol concentrations up to 0.63 g/kg is not exceeded.
- Published
- 2022
- Full Text
- View/download PDF
62. Strangulation – Erhängen
- Author
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Pollak, S., primary and Thierauf-Emberger, A., additional
- Published
- 2021
- Full Text
- View/download PDF
63. Optimization of DBS-self sampling for PEth in a drinking experiment with standard DBS cards and with a new design of volumetric DBS card
- Author
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Wolfgang Weinmann, Frederike Stöth, Philipp Pütz, Dominik Schuldis, and Annette Thierauf-Emberger
- Subjects
Health, Toxicology and Mutagenesis ,Toxicology - Published
- 2022
64. Diverging prefrontal cortex fiber connection routes to the subthalamic nucleus and the mesencephalic ventral tegmentum investigated with long range (normative) and short range (ex-vivo high resolution) 7T DTI
- Author
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Coenen, Volker A., primary, Döbrössy, Máté D., additional, Teo, Shi Jia, additional, Wessolleck, Johanna, additional, Sajonz, Bastian E. A., additional, Reinacher, Peter C., additional, Thierauf-Emberger, Annette, additional, Spittau, Björn, additional, Leupold, Jochen, additional, von Elverfeldt, Dominik, additional, Schlaepfer, Thomas E., additional, and Reisert, Marco, additional
- Published
- 2021
- Full Text
- View/download PDF
65. Klinische Rechtsmedizin und forensisch-klinische Untersuchungen
- Author
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Kernbach-Wighton, Gerhard, primary, Banaschak, Sibylle, additional, Madea, Burkhard, additional, Pollak, Stefan, additional, Thierauf-Emberger, Annette, additional, Tsokos, Michael, additional, Geserick, Gunther, additional, Schmeling, Andreas, additional, and Saternus, Klaus-Steffen, additional
- Published
- 2014
- Full Text
- View/download PDF
66. Traumatologie und gewaltsamer Tod
- Author
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Wegener, Rudolf, primary, Tsokos, Michael, additional, Bratzke, Hansjürgen, additional, Oehmichen, Manfred, additional, Pollak, Stefan, additional, Maxeiner, Helmut, additional, Keil, Wolfgang, additional, Kettner, Mattias, additional, Schmidt, Peter, additional, Lignitz, Eberhard, additional, Thierauf-Emberger, Annette, additional, Banaschak, Sibylle, additional, Bajanowski, Thomas, additional, Geserick, Gunther, additional, Lessig, Rüdiger, additional, Henn, Véronique, additional, Buschmann, Claas T., additional, Kleber, Christian, additional, Wehner, Heinz-Dieter, additional, and Madea, Burkhard, additional
- Published
- 2014
- Full Text
- View/download PDF
67. Masking of Homicide
- Author
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Stefan Pollak and Annette Thierauf-Emberger
- Subjects
Surprise ,Homicide ,Natural death ,media_common.quotation_subject ,External Examination ,Smothering ,Criminology ,Element (criminal law) ,Literature survey ,Psychology ,Masking (Electronic Health Record) ,media_common - Abstract
Intentional simulation and dissimulation of criminal acts are behaviour patterns frequently met in both police investigations and forensic medicine. Even more worrying are homicide cases disguised as suicides, accidents or natural deaths, which may be misinterpreted due to secondary cover-up activities of the perpetrator. In addition to that, it is common knowledge that the postmortem examination of strangled victims is prone to errors. A mere external examination of the deceased necessarily leaves part of the strangulation deaths undetected. On the other hand, a homicide by smothering may be covered up as a plastic bag suicide. The literature survey of Maync mentions 6 out of 13 cases in which adult victims were hanged by single perpetrators without significant superiority of physical strength. Thorough planning, in combination with an element of surprise, may be just as effective as mere physical overpowering, especially in unsuspecting victims.
- Published
- 2020
68. Pitfalls and Mistakes
- Author
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Stefan Pollak and Annette Thierauf-Emberger
- Subjects
business.industry ,Medicine ,business - Published
- 2020
69. Survived Neck Compression
- Author
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Stefan Pollak and Annette Thierauf-Emberger
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Radiology ,Compression (physics) ,business - Published
- 2020
70. Nachweis von Rauschmitteln im rechtsmedizinischen Untersuchungsgut: eine wichtige Grundlage für die Begutachtung der Schuldfähigkeit
- Author
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Stefan Pollak and Annette Thierauf-Emberger
- Published
- 2020
71. A moving human body causes fatal blunt trauma: an unusual traffic accident
- Author
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Stefan Pollak, Andreas Lickert, and Annette Thierauf-Emberger
- Subjects
medicine.medical_specialty ,Acceleration ,Autopsy ,Wounds, Nonpenetrating ,Sitting ,01 natural sciences ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Blunt ,medicine ,Humans ,030216 legal & forensic medicine ,Depression (differential diagnoses) ,Human Body ,Foramen magnum ,Traffic accident ,business.industry ,010401 analytical chemistry ,Accidents, Traffic ,Middle Aged ,Bicycling ,0104 chemical sciences ,Surgery ,Skull ,medicine.anatomical_structure ,Blunt trauma ,Female ,business ,human activities - Abstract
In urban traffic accidents, mainly pedestrians and cyclists are at risk of being injured and killed. Lethal injuries are usually caused by the immediate impact of a car or a tram. This paper presents a fatal accident without any direct contact with a motor vehicle. A 63-year-old woman sitting on a chair in a pavement cafe was killed by the impact of a 60-year-old male cyclist, who was flung in her direction after colliding with a car. Autopsy yielded intracutaneous haemorrhages on the impact sites of the female victim (left cheek, left shoulder and left upper arm). The woman sustained a ring fracture of the skull base encircling the foramen magnum with subtotal severance of the brain stem and massive chest trauma. All the injuries were caused by the blunt impact of the moving human body. The head was forcibly bent towards the contralateral shoulder resulting in a depression fracture of the skull. Reconstruction of the accident at the scene was challenging, as the fatally injured victim remained sitting on the chair and did not show any striking external signs of traumatisation. According to the assessment of the technical expert, the collision velocity of the moving body amounted to 6-8 m/s.
- Published
- 2018
72. Correction to: Comparison of ethanol concentrations in the human brain determined by magnetic resonance spectroscopy and serum ethanol concentrations
- Author
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Annette Thierauf-Emberger, Michael Dacko, Thomas Lange, and Judith Echle
- Subjects
Cerebellum ,Ethanol ,Chromatography ,Frontal cortex ,Putamen ,Venous blood ,Nuclear magnetic resonance spectroscopy ,Human brain ,Pathology and Forensic Medicine ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Cortex (anatomy) ,medicine - Abstract
Ethanol is a widespread substance that inherits desired effects, but also negative consequences with regard to DUI or battery. Where required, the ethanol concentration is usually determined in peripheral venous blood samples, while the brain is the target organ of the ethanol effects. The aim of this study with three participants was the determination of the ethanol concentration in functionally relevant regions of the brain and the comparison with serum ethanol concentrations. After the uptake of ethanol in a calculated amount, leading to a serum ethanol concentration of 0.99 g/L, the ethanol concentrations in the brain were directly analyzed by means of magnetic resonance spectroscopy on a 3 Tesla human MRI system and normalized to the water content. The measurement voxels were located in the occipital cortex, the cerebellum, the frontal cortex, and the putamen and successively examined. Intermittently blood samples were taken, and serum was analyzed for ethanol using HS-GC-FID. Ethanol concentrations in brain regions normalized to the water content were lower than the measured serum ethanol results and rather homogenous within the three participants and the various regions of the brain. The maximum ethanol concentration in the brain (normalized to water content) was 0.68 g/L. It was measured in the frontal cortex, in which the highest results were gained. The maximum serum concentration was 1.19 g/L. The course of the brain ethanol curve seems to be flatter than the one of the serum ethanol concentrations.
- Published
- 2021
73. Wound morphology in contact shots from blank cartridge handguns: a study on composite models
- Author
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Stefan Pollak, Markus Große Perdekamp, Rebecca Pircher, Dorothee Geisenberger, Lena Violetta Krämer, and Annette Thierauf-Emberger
- Subjects
Firearms ,Materials science ,Forensic Ballistics ,Swine ,Perforation (oil well) ,Composite number ,Poison control ,Models, Biological ,01 natural sciences ,Blank ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Humans ,030216 legal & forensic medicine ,Composite material ,Penetration depth ,Blank cartridge ,Skin ,Jet (fluid) ,integumentary system ,business.industry ,010401 analytical chemistry ,Structural engineering ,0104 chemical sciences ,Models, Animal ,Gelatin ,Wounds, Gunshot ,Wound - morphology ,business - Abstract
It is a well-known fact that blank cartridge guns can cause penetrating and even fatal injuries when discharged in contact or at very close ranges. In these cases, the gas jet perforates the skin leaving an entrance wound similar to that from a conventional gun. In order to investigate the wound morphology in contact shots from blank firearms, test shots were fired at composite models of pig skin and gelatin blocks using three different calibre 9-mm blank cartridge handguns (two pistols and one revolver) and two types of ammunition. It turned out that the penetrating gas jet produced roundish skin defects resembling bullet entrance holes. Small skin particles from the perforation site were dispersed in the underlying simulant where radiating cracks containing greyish gunshot residues indicated the original expansion of the inrushing combustion gases. Apart from the size of the permanent entrance hole in the skin and the final position of the displaced tissue particles, the penetration depth of the gas jet was determined. Under the specified conditions of the test shots, the zone of mechanical destruction within the simulant was 2.2 to 6.1 cm in length, which illustrates the injuring potential of contact shots inflicted with blank cartridge handguns.
- Published
- 2017
74. Bullet wipe on the uppermost textile layer of gunshot entrance sites: may it be absent due to pre-existing blood staining?
- Author
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Stefan Pollak, Dorothee Geisenberger, Annette Thierauf-Emberger, Katrin Mierdel, Rebecca Pircher, and Markus Große Perdekamp
- Subjects
Firearms ,Materials science ,Cyclohexanones ,Forensic Ballistics ,Textiles ,010401 analytical chemistry ,Criminal case ,01 natural sciences ,0104 chemical sciences ,Pathology and Forensic Medicine ,Blood staining ,03 medical and health sciences ,Cartridge ,0302 clinical medicine ,Wide area ,Blood Stains ,Body region ,Wounds, Gunshot ,030216 legal & forensic medicine ,Composite material ,Sodium rhodizonate - Abstract
Most gunshot entrance sites on human victims are localized in clothed body regions. Except for the use of lead-free ammunition, a positive color reaction of the sodium rhodizonate test indicates a primary target hit by the bullet. Any lead residue pattern in the area around the entrance hole allows approximate conclusions as to the firing distance in close and intermediate range shots, whereas the presence of a bullet wipe denotes an entrance site. A criminal case gave rise to an experimental study to clarify whether a blood-soaked garment being shot at as a primary target may lack a bullet wipe around the entrance hole. Distant-range shots were fired with a semi-automatic pistol (Heckler & Koch, Mod. USP Compact, cal. 9-mm Luger) using cartridges with jacketed round-nose bullets and a Sinoxid primer containing lead styphnate. In fabrics saturated with fluid blood, a wide area around the bullet entrance was densely covered with rhodizonate-positive microparticles simulating gunshot residues (GSR) from a close-range shot. In shots to fabrics oversaturated with blood, a typical bullet wipe was lacking, whereas lead-containing particles were spotted in the periphery. The results are discussed with respect to the aberrant appearance of bullet entrance sites in blood-soaked fabrics.
- Published
- 2019
75. Detection of the ethanol consumption markers ethyl glucuronide and ethyl sulfate in urine samples from inmates of two German prisons
- Author
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Volker Auwärter, Anette Franz, Annette Thierauf-Emberger, and Laura M. Huppertz
- Subjects
Male ,Alcohol Drinking ,Injury control ,media_common.quotation_subject ,Poison control ,Glucuronates ,Urine ,Sulfuric Acid Esters ,01 natural sciences ,Ethyl sulfate ,Pathology and Forensic Medicine ,Toxicology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ethyl glucuronide ,Tandem Mass Spectrometry ,Germany ,Humans ,Medicine ,030216 legal & forensic medicine ,media_common ,Ethanol ,business.industry ,Prisoners ,010401 analytical chemistry ,Environmental engineering ,Abstinence ,0104 chemical sciences ,Cross-Sectional Studies ,chemistry ,Urine sample ,business ,Biomarkers ,Chromatography, Liquid - Abstract
Introduction Abstinence from ethanol is necessary in various situations. Among these are jail terms. Nevertheless, it is a matter of fact that ethanol is illegally produced and ingested in prisons. So far, data regarding drug prevalence in jail have mainly been collected by questionnaires. To get an objective database for the prevalence of ethanol consumption in jail, a cross-sectional study was performed. Methods Inmates of two German prisons (Offenburg and Freiburg) were asked to give a urine sample at an unknown and random point of time. Participation was voluntary and did lead to neither negative consequences nor benefits. All samples were anonymized. Using the consumption markers ethyl glucuronide (EtG) and ethyl sulfate (EtS), the urine samples were tested for previous ethanol consumption. Analyses were performed by a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Results In total 676 male inmates participated in this study. The participation rate was 70–75 % of all permanent inmates in Offenburg and 30.6 % in Freiburg. Ten of the 555 (1.8 %) samples from Offenburg and 1 of the 121 (0.8 %) samples from Freiburg were positive for ethanol consumption markers with concentrations ranging from trace amounts to 1400 ng/mL for EtG and up to 510 ng/mL for EtS, respectively. Conclusions The number of participants in this study was rather high, so that the results represent a good cross section, at least for Offenburg, the jail with the higher number of positive samples.
- Published
- 2015
76. Nagelschraube im Kopf eines Kindes
- Author
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Anette Thierauf-Emberger and Stefan Pollak
- Subjects
Gynecology ,medicine.medical_specialty ,media_common.quotation_subject ,medicine ,Art ,media_common - Abstract
Ein knapp 2-jahriger Junge mit einer Nagelschraube im Kopf wird in die Notfallambulanz eines Krankenhauses gebracht. Die Arzte zweifeln an den Angaben der Eltern und konnen Kindesmisshandlung nicht sicher ausschliesen. Deshalb lassen sie den Fall rechtsmedizinisch untersuchen — mit einem erstaunlichen Ergebnis.
- Published
- 2016
77. Penetrierende Kopfverletzung durch eine Nagelschraube
- Author
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Stefan Pollak and Annette Thierauf-Emberger
- Subjects
Gynecology ,medicine.medical_specialty ,Philosophy ,medicine ,Pathology and Forensic Medicine - Abstract
Penetrierende Verletzungen des Gehirnschadels werden uberwiegend als Schussfolgen beobachtet. Zu den moglichen Ursachen zahlen auch die baugewerblich verwendeten Bolzensetzgerate und Nagelschussapparate. Die daraus verschossenen Schrauben und Nagel konnen im Fall eines Freiflugs selbst knocherne Strukturen durchdringen. Berichtet wird uber die konsiliarische rechtsmedizinische Beurteilung eines 22 Monate alten Jungen, der wegen einer penetrierenden Kopfverletzung in eine Notfallambulanz gebracht worden war. Die Eltern gaben an, das Kind habe sich die Verletzung bei einem Sturz vom Dreirad zugezogen. In der Stirnhaut steckte der Kopf einer Nagelschraube, die 4,5 cm tief ins Schadelinnere ragte. Die Gesamtheit der berichteten Umstande und der medizinischen Befunde sprach dafur, dass der Junge unfallmasig von einer frei fliegenden Nagelschraube aus einem baugewerblichen Schussapparat getroffen wurde. Der intrakranielle Fremdkorper wurde entfernt; der postoperative Heilungsverlauf war komplikationslos.
- Published
- 2014
78. Suicide with two makes of captive-bolt guns (livestock stunners) fired simultaneously to the forehead
- Author
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Stefan Pollak, Merja A. Neukamm, Dorothee Geisenberger, Markus Große Perdekamp, Ulrike Schmidt, Annette Thierauf-Emberger, and Rebecca Pircher
- Subjects
Male ,Engineering ,Firearms ,Injury control ,Surface relief ,Poison control ,Slaughterer ,01 natural sciences ,Suicide prevention ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Soot ,medicine ,Forensic engineering ,Head Injuries, Penetrating ,Humans ,030216 legal & forensic medicine ,Frontal region ,Muzzle ,Aged ,business.industry ,010401 analytical chemistry ,Equipment Design ,0104 chemical sciences ,Suicide ,medicine.anatomical_structure ,Forehead ,Wounds, Gunshot ,business - Abstract
In humans, most fatalities from slaughterer's guns are suicides committed by persons familiar with stunning devices. The great majority of cases accounts for shots to the head, especially the frontal region. Only a small number of two subsequent cranial shots from captive-bolt humane killers have been reported up to now. In the case presented by the authors, a suicide by simultaneous shots to the head fired from two different makes of captive-bolt guns (one of them having two separate outlets for the combustion gases in the muzzle plane, the other type having no additional openings) is described for the first time. One of the shooting devices remained in firm contact with the left hand and produced patterned staining from rust corresponding to the surface relief of the gun. The medicolegal and criminalistic aspects of this unique case are discussed with reference to the pertinent literature.
- Published
- 2016
79. A moving human body causes fatal blunt trauma: an unusual traffic accident
- Author
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Thierauf-Emberger, Annette, primary, Lickert, Andreas, additional, and Pollak, Stefan, additional
- Published
- 2018
- Full Text
- View/download PDF
80. The influence of the bullet shape on the width of abrasion collars and the size of gunshot entrance holes
- Author
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Dorothee Geisenberger, Markus Große Perdekamp, Annette Thierauf-Emberger, Rebecca Pircher, Stefan Pollak, and Demet Preiß
- Subjects
Materials science ,Forensic Ballistics ,Swine ,01 natural sciences ,Pathology and Forensic Medicine ,Abrasion (geology) ,Collar ,Pig skin ,03 medical and health sciences ,Cartridge ,0302 clinical medicine ,Optics ,Animals ,030216 legal & forensic medicine ,Skin pathology ,Hole size ,Skin ,integumentary system ,business.industry ,Projectile ,010401 analytical chemistry ,Structural engineering ,0104 chemical sciences ,Models, Animal ,Wounds, Gunshot ,business ,Bullet (shape) - Abstract
To investigate if there is any correlation between the bullet design and the respective dimensions of the abrasion collar and the skin defect in gunshot entrance wounds, experimental studies were performed on dyed pig skin. For the test shots, .38 Special revolver cartridges with three different bullet designs (round nose, wadcutter, and truncated cone) were used. With the help of an image editing program in combination with an image analyzing system, the area size of the abrasion rings and the skin defects was calculated automatically. The measured values differed significantly depending on the bullet type: the abrasion ring areas were largest in shots with round nose bullets and smallest with wadcutter projectiles. With regard to the entrance hole size, the relationship was inverse. The results are discussed with reference to the pertinent literature concerning the dynamic interaction between bullet and skin.
- Published
- 2016
81. Phosphatidylethanol (PEth) detected in blood for 3 to 12 days after single consumption of alcohol—a drinking study with 16 volunteers
- Author
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Wolfgang Weinmann, Annette Thierauf-Emberger, Alexandra Schröck, and Stefan Schürch
- Subjects
Alcohol Drinking ,media_common.quotation_subject ,Alcohol abuse ,Physiology ,Alcohol ,610 Medicine & health ,Glycerophospholipids ,Urine ,01 natural sciences ,Mass Spectrometry ,Ethyl sulfate ,Pathology and Forensic Medicine ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ethyl glucuronide ,Humans ,Medicine ,media_common ,Chromatography ,Alcohol Abstinence ,business.industry ,Solid Phase Extraction ,010401 analytical chemistry ,Diagnostic marker ,Abstinence ,medicine.disease ,0104 chemical sciences ,chemistry ,Blood Alcohol Content ,Female ,Phosphatidylethanol ,business ,Biomarkers ,030217 neurology & neurosurgery ,Chromatography, Liquid - Abstract
In most studies, the alcohol marker phosphatidylethanol (PEth) was used to differentiate social drinking from alcohol abuse. This study investigates PEth's potential in abstinence monitoring by performing a drinking study to assess the detection window of PEth after ingesting a defined amount of alcohol. After 2 weeks of abstinence, 16 volunteers ingested a single dose of alcohol, leading to an estimated blood alcohol concentration (BAC) of 1 g/kg. In the week after drinking, blood and urine samples were taken daily; in the second week, samples were taken every other day. PEth 16:0/18:1 and 16:0/18:2 were analyzed in blood by online-SPE-LC-MS/MS. Ethyl glucuronide and ethyl sulfate were determined in urine for abstinence monitoring. Prior to start of drinking, PEth 16:0/18:1 exceeded 30 ng/mL in blood samples of five volunteers despite the requested abstinence period. Positive PEth values resulted from drinking events prior to this abstinence period. After the start of drinking, maximum BACs were reached after 2 h with a mean of 0.80 ± 0.13 g/kg (range: 0.61-1.11 g/kg). PEth 16:0/18:1 increased within 8 h to maximum concentrations (mean: 88.8 ± 47.0 ng/mL, range: 37.2-208 ng/mL). After this event, PEth was detectable for 3 to 12 days with a mean half-life time of approximately 3 days. PEth has a potential in abstinence monitoring, since PEth could be detected for up to 12 days after a single drinking event. Further investigations are necessary, to establish cut-off levels for PEth as diagnostic marker for the determination of drinking habits like abstinence, social drinking, or risky alcohol consumption.
- Published
- 2016
82. [Fire disaster due to deflagration of a propane gas-air mixture]
- Author
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Hadi, Nadjem, Susanne, Vogt, Karl-Heinz, Simon, Stefan, Pollak, Dorothee, Geisenberger, Lena, Kramer, Rebecca, Pircher, Markus Große, Perdekampl, and Annette, Thierauf-Emberger
- Subjects
Propane ,Blast Injuries ,Multiple Trauma ,Air ,Germany ,Explosions ,Humans ,Forensic Medicine ,Burns ,Fires - Abstract
On 26 Nov 2012, a serious fire occurred at Neustadt/Black Forest in which 14 persons in a sheltered workshop died and 10 other individuals were injured. The fire was caused by the unbridled escape of propane gas due to accidental disconnection of the screw fixing between a gas bottle and a catalytic heater. Deflagration of the propane gas-air mixture set the workshop facilities on fire. In spite of partly extensive burns the fatally injured victims could be rapidly identified. The results of the fire investigations at the scene and the autopsy findings are presented. Carboxyhemoglobin concentrations ranged between 8 and 56 % and signs of fire fume inhalation were present in all cases. Three victims had eardrum ruptures due to the sudden increase in air pressure during the deflagration.
- Published
- 2015
83. The influence of the bullet shape on the width of abrasion collars and the size of gunshot entrance holes
- Author
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Pircher, Rebecca, primary, Preiß, Demet, additional, Pollak, Stefan, additional, Thierauf-Emberger, Annette, additional, Perdekamp, Markus Große, additional, and Geisenberger, Dorothee, additional
- Published
- 2016
- Full Text
- View/download PDF
84. Homicidal assault to the neck with subsequent simulation of self-hanging
- Author
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Stefan Pollak and Annette Thierauf-Emberger
- Subjects
Male ,Deception ,Injury control ,Accident prevention ,Contusions ,Poison control ,Criminology ,Computer security ,computer.software_genre ,Suicide prevention ,Pathology and Forensic Medicine ,Neck Injuries ,Asphyxia ,Fractures, Bone ,Homicide ,Injury prevention ,Humans ,Purpura ,Hematoma ,Hyoid Bone ,Middle Aged ,Suicide ,Female ,Psychology ,Law ,computer - Abstract
When a body is found in suspended position, not only suicidal hanging has to be considered but also an accident or homicide. These alternatives and the criteria to be applied for their differentiation were already extensively discussed in the old medico-legal literature. Nevertheless, it is still a challenge for detectives and forensic experts to prove a homicidal assault when a suspended body is found. In the presented case, the findings collected at the scene and during autopsy seemed to be consistent with the assumption of suicide at first and the case has only been elucidated by supplementary inquiries and a secondary evaluation of the photos taken at the scene and during the autopsy. The victim, a 47-year-old woman, had been manually strangled in her flat. Subsequently, the perpetrator took her up to the attic and tried to hang her in order to simulate suicide.
- Published
- 2015
85. Influence of Gilbert's syndrome on the formation of ethyl glucuronide
- Author
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Leonie Gunsilius, Wolfgang Weinmann, Laura M. Huppertz, Christelle Lardi, and Annette Thierauf-Emberger
- Subjects
Adult ,Male ,medicine.medical_specialty ,Glucuronosyltransferase ,Adolescent ,Alcohol Drinking ,Bilirubin ,Glucuronidation ,Glucuronates ,610 Medicine & health ,Urine ,Sulfuric Acid Esters ,Ethyl sulfate ,Pathology and Forensic Medicine ,chemistry.chemical_compound ,Young Adult ,Ethyl glucuronide ,Tandem Mass Spectrometry ,Internal medicine ,medicine ,Gilbert Disease/metabolism ,Humans ,Glucuronates/urine ,Aged ,Sulfuric Acid Esters/urine ,Ethanol ,biology ,Biomarkers/urine ,ddc:614.1 ,Ethanol/blood/pharmacokinetics ,Central Nervous System Depressants ,Middle Aged ,medicine.disease ,Gilbert's syndrome ,Endocrinology ,chemistry ,Biochemistry ,biology.protein ,Female ,Gilbert Disease ,Biomarkers ,Central Nervous System Depressants/blood/pharmacokinetics ,Chromatography, Liquid - Abstract
A drinking experiment with participants suffering from Gilbert's syndrome was performed to study the possible influence of this glucuronidation disorder on the formation of ethyl glucuronide (EtG). Gilbert's syndrome is a rather common and, in most cases, asymptomatic congenital metabolic aberration with a prevalence of about 5 %. It is characterized by a reduction of the enzyme activity of the uridine diphosphate glucuronosyltransferase (UGT) isoform 1A1 up to 80 %. One of the glucuronidation products is EtG, which is formed in the organism following exposure to ethanol. EtG is used as a short-term marker for ethyl alcohol consumption to prove abstinence in various settings. After 2 days of abstinence from ethanol and giving a void urine sample, 30 study participants drank 0.1 L of sparkling wine (9 g ethanol). 3, 6, 12, and 24 h after drinking, urine samples were collected. 3 hours after drinking, an additional blood sample was taken, in which liver enzyme activities, ethanol, hematological parameters, and bilirubin were measured. EtG and ethyl sulfate (EtS), another short-term marker of ethanol consumption, were determined in the urine samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS); creatinine was measured photometrically. In all participants, EtG and EtS were detected in concentrations showing a wide range (EtG: 3 h sample 0.5-18.43 mg/L and 6 h sample 0.67-13.8 mg/L; EtS: 3 h sample 0.87-6.87 mg/L and 6 h sample 0.29-4.48 mg/L). No evidence of impaired EtG formation was found. Thus, EtG seems to be a suitable marker for ethanol consumption even in individuals with Gilbert's syndrome.
- Published
- 2015
- Full Text
- View/download PDF
86. Zur forensischen Bedeutung des Boerhaave-Syndroms.
- Author
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Thierauf-Emberger, Annette, Geisenberger, Dorothee, Pollak, Stefan, and Schmidt, Ulrike
- Published
- 2019
87. Kriminalistische und rechtsmedizinische Aspekte suizidaler Vergiftungen mit Pflanzenteilen der Eibe (Taxus baccata).
- Author
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Perdekamp, Markus Große, Auwärter, Volker, Geisenberger, Dorothee, Pircher, Rebecca, Pollak, Stefan, Schmidt, Ulrike, Thierauf-Emberger, Annette, Thoma, Vanessa, and Vogt, Susanne
- Published
- 2019
88. Traumatologie und gewaltsamer Tod
- Author
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Gunther Geserick, R. Wegener, Eberhard Lignitz, Christian Kleber, W. Keil, S. Banaschak, Peter H. Schmidt, Thomas Bajanowski, Manfred Oehmichen, Stefan Pollak, Burkhard Madea, Hansjürgen Bratzke, Heinz-Dieter Wehner, Helmut Maxeiner, Claas T. Buschmann, Rüdiger Lessig, Mattias Kettner, Michael Tsokos, Véronique Henn, and Annette Thierauf-Emberger
- Abstract
Forensisch-traumatologische Untersuchungen sind in vielfaltigen rechtlichen Zusammenhangen von Bedeutung; sie dienen der Befunderhebung, Dokumentation und Asservierung. Bei der Beurteilung von Verletzungen sind Suizide, Suizidversuche, Selbstbeschadigungen einerseits, Unfalle und Unglucksfalle sowie Korperverletzungs- und Totungsdelikte andererseits zu differenzieren. Unter Traumatomechanik versteht man eine schadigende Krafteinwirkung, die uber eine Deformation eine Kontinuitatsunterbrechung, also eine Gefugetrennung des Gewebes nach sich zieht. Gewalteinwirkungen werden hinsichtlich ihrer Verursachung eingeteilt in mechanische Insulte (stumpfe und scharfe Gewalt), Schussverletzungen, Erstickungen, Tod im Wasser, thermische Energie (Hitze, Kalte), Elektrizitat, Blitzschlag, Strahlen, Verhungern, Vernachlassigung, Kindstotung, Abtreibung, Tod in abnormer Korperposition etc.
- Published
- 2014
89. Klinische Rechtsmedizin und forensisch-klinische Untersuchungen
- Author
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Gunther Geserick, Annette Thierauf-Emberger, Gerhard Kernbach-Wighton, Stefan Pollak, Michael Tsokos, S. Banaschak, Burkhard Madea, Klaus-Steffen Saternus, and Andreas Schmeling
- Abstract
Aufgrund des Erfahrungsschatzes in der Erhebung, Protokollierung und Dokumentation von Verletzungsbefunden sind Rechtsmediziner seit altersher auch mit der Untersuchung Lebender nach rechtserheblichen Korperverletzungen befasst (Beweismittelsicherung am Lebenden), damit sich entsprechend erhobene Befunde und ihre Beurteilung im weiteren Verfahrensablauf als tragfahig erweisen. Das rechtsmedizinische Untersuchungsspektrum inkl. Asservation nach Sexualdelikten ist weitgehend normiert. Bei Kindesmisshandlung steht die Abgrenzung von haufig behaupteten akzidentellen Verletzungen im Vordergrund. Selbstbeschadigungen weisen typische Verletzungscharakteristika auf. In den letzten Jahren spielt die forensische Altersdiagnostik bei Lebenden eine zunehmende Rolle. Aufgabe eines Altersgutachtens ist eine Aussage zum chronologischen Alter aufgrund des physischen Entwicklungszustandes eines Individuums, welcher als biologisches Alter bezeichnet wird.
- Published
- 2014
90. Differences between the measured blood ethanol concentration and the estimated concentration by Widmark's equation in elderly persons
- Author
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Volker Auwärter, Lena Bielefeld, Stefan Pollak, and Annette Thierauf-Emberger
- Subjects
Adult ,Male ,medicine.medical_specialty ,Injury control ,Coefficient of variation ,Poison control ,Models, Biological ,Pathology and Forensic Medicine ,Forensic Toxicology ,Young Adult ,Animal science ,Elderly persons ,Blood alcohol ,Medicine ,Humans ,Aged ,Aged, 80 and over ,Flame Ionization ,Ethanol ,business.industry ,Age Factors ,Central Nervous System Depressants ,Blood ethanol ,Mean age ,Middle Aged ,Surgery ,Blood Alcohol Content ,Female ,business ,Ethanol intoxication ,Law ,Alcoholic Intoxication - Abstract
BACKGROUND: The Widmark's equation (C [BAC]=A/p×r) is the most commonly used formula in legal medicine to estimate the blood alcohol concentration (BAC) from the amount of ingested ethanol and vice versa. Within a drinking experiment with a target BAC of 1.2g/kg, a 75-year-old participant reached a maximum BAC of 1.83g/kg and showed signs of severe ethanol intoxication, while the other nine subjects (age: 19-31 years) had BACs close to the target BAC. This incident brought up the question, if the Widmark's equation is an appropriate tool for aged persons. METHODS: A drinking experiment with 50 elderly voluntary test persons (22 males, 28 females, mean age and range [males]: 69.7 years, 60-84 years, mean age and range [females]: 68.5 years, 61-78 years) was performed. The amount of ethanol leading to a BAC of 0.6g/kg was estimated individually using the Widmark's equation (used Widmark factors: 0.7 for males, 0.6 for females). After drinking, the blood ethanol concentrations were measured using headspace gas chromatography/flame ionization detection. RESULTS: The measured maximum BACs of the elderly participants were significantly higher (α=0.01) than the target BAC (mean maximum BAC and range: 0.627g/kg, 0.3-0.81g/kg, for males: 0.616g/kg, 0.32-0.78g/kg, for females: 0.635g/kg, 0.3-0.81). The calculated Widmark factors showed a high coefficient of variation (for males: 0.7±0.138 [0.55-1.2, CV: 19.7%], for females 0.59±0.119 [0.46-1.08, CV: 20.2%]). CONCLUSION: The results demonstrate that BAC calculations by Widmark's equation in elderly individuals may be complicated by a high variation of Widmark factors. There is a tendency to an elevation of the actual BAC with increasing age. Language: en
- Published
- 2014
91. Fat from contused adipose tissue may cause yellow discoloration of clothes in blunt trauma victims
- Author
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F. Wuest, Rebecca Pircher, Dorothee Geisenberger, L.M. Huppertz, Lena Bielefeld, Stefan Pollak, M. Große Perdekamp, and Annette Thierauf-Emberger
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Contusions ,Adipose tissue ,Color ,Gas Chromatography-Mass Spectrometry ,Pathology and Forensic Medicine ,Clothing ,Yellow discoloration ,chemistry.chemical_compound ,Young Adult ,medicine ,Humans ,Aged ,business.industry ,Fatty Acids ,Anatomy ,Middle Aged ,Oleic acid ,chemistry ,Adipose Tissue ,Blunt trauma ,Female ,Fatty acid composition ,business ,Law - Abstract
In some fatalities from intense blunt trauma, the victims’ clothes show strikingly yellow discoloration being in topographic correspondence with lacerated skin and crush damage to the underlying fatty tissue. This phenomenon is especially pronounced in light-colored textiles such as underwear made of cotton and in the absence of concomitant blood-staining. The constellation of findings seems to indicate that the fabric has been soaked with liquid body fat deriving from the contused adipose tissue. To check this hypothesis, textiles suspected to be contaminated with fat were investigated in 6 relevant cases. GC–MS-analysis proved the presence of 11 fatty acids. The fatty acid composition was similar to that of human adipose tissue with a high proportion of oleic acid (18:1). In total, the morphological and chemical findings demonstrated that the yellow discoloration of the victims’ clothes was caused by fat from traumatized adipose tissue.
- Published
- 2014
92. Muzzle imprint mark: a patterned injury which may be constituted of intradermal blood extravasations
- Author
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Lena Bielefeld, Rebecca Pircher, Stefan Pollak, M. Große Perdekamp, Annette Thierauf-Emberger, and Dorothee Geisenberger
- Subjects
Male ,medicine.medical_specialty ,Surface relief ,Injury control ,Abrasion (medical) ,Poison control ,Occipital region ,Pathology and Forensic Medicine ,medicine ,Head Injuries, Penetrating ,Humans ,Forensic Pathology ,Muzzle ,Skin ,Hematoma ,integumentary system ,Anatomy ,medicine.disease ,Surgery ,Suicide ,medicine.anatomical_structure ,Forehead ,Brown color ,Female ,Wounds, Gunshot ,Homicide ,Law ,Geology - Abstract
The muzzle imprint mark in contact shots is usually regarded as a patterned pressure abrasion depicting the barrel end as well as adjacent constructional components of the weapon. Due to parching after exposure to air, the affected skin assumes a brown color, especially along the contours of the impacting structures. Apart from this well-known type of epidermal damage, the imprint mark may also be formed by intradermal hemorrhages. In some cases, these intracutaneous bleedings manifest themselves as circular, curved or straight reddish lines mirroring the surface relief of the weapon's muzzle end. To estimate the frequency of skin hematomas in muzzle imprints, 35 consecutive contact shots to the head (temple, forehead, submental and occipital region) were evaluated. In 3 cases, the muzzle imprint mark exclusively consisted of intracutaneous bruises surrounding the bullet entrance hole. In 14 cases, the muzzle imprint was composed of both excoriations and intradermal hematomas.
- Published
- 2014
93. Nagelschraube im Kopf eines Kindes
- Author
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Thierauf-Emberger, Anette, primary and Pollak, Stefan, additional
- Published
- 2016
- Full Text
- View/download PDF
94. Phosphatidylethanol (PEth) detected in blood for 3 to 12 days after single consumption of alcohol—a drinking study with 16 volunteers
- Author
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Schröck, Alexandra, primary, Thierauf-Emberger, Annette, additional, Schürch, Stefan, additional, and Weinmann, Wolfgang, additional
- Published
- 2016
- Full Text
- View/download PDF
95. Homicidal assault to the neck with subsequent simulation of self-hanging
- Author
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Pollak, Stefan, primary and Thierauf-Emberger, Annette, additional
- Published
- 2015
- Full Text
- View/download PDF
96. Detection of the ethanol consumption markers ethyl glucuronide and ethyl sulfate in urine samples from inmates of two German prisons
- Author
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Thierauf-Emberger, Annette, primary, Franz, Anette, additional, Auwärter, Volker, additional, and Huppertz, Laura M., additional
- Published
- 2015
- Full Text
- View/download PDF
97. Folgenschwerer Brand durch Entzündung eines Propangas-Luft-Gemisches.
- Author
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Nadjem, Hadi, Vogt, Susanne, Simon, Karl-Heinz, Poliak, Stefan, Geisenberger, Dorothee, Kramer, Lena, Pircher, Rebecca, Perdekamp, Markus Große, and Thierauf-Emberger, Annette
- Abstract
Copyright of Archiv für Kriminologie is the property of Schmidt-Roemhild Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2015
98. Can PEth be Detected with a Cutoff of 20 ng/mL after Single Alcohol Consumption?
- Author
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Stöth F, Kotzerke E, Thierauf-Emberger A, Weinmann W, and Schuldis D
- Subjects
- Humans, Alcohol Drinking, Chromatography, Liquid, Ethanol, Blood Alcohol Content, Glycerophospholipids, Biomarkers, Alcoholism, Substance Withdrawal Syndrome
- Abstract
Phosphatidylethanol (PEth) can be determined in capillary blood collected as dried blood spots (DBS) and is a promising direct alcohol biomarker for the determination of drinking habits. Its use for abstinence monitoring needs to be evaluated. Studies with patients undergoing alcohol withdrawal have shown that the elimination of PEth can take up to 2 months. For the determination of PEth 16:0/18:1, a cutoff of 20 ng/mL has been agreed upon in the major US laboratories. However, it is not yet clear what minimum blood alcohol concentrations (BACs) have to be achieved by a single drinking episode to result in PEth concentrations above this cutoff after previous long-term abstinence. To determine whether low drinking amounts can result in a positive PEth concentration above 20 ng/mL, we recruited 12 participants ('social' drinkers). After 4 weeks of abstinence, alcohol was consumed at two separate drinking events with target BACs of 0.5 and 0.3 g/kg, resulting in maximum BACs in the ranges of 0.30-0.63 g/kg and 0.10-0.28 g/kg, respectively. Capillary blood was collected at different time points of the drinking experiment, and PEth was extracted from DBS and analyzed by liquid chromatography-tandem mass spectrometry. Despite drinking doses up to 0.58 g ethanol per kg body weight and reaching BACs of up to 0.63 g/kg, PEth 16:0/18:1 and PEth 16:0/18:2 could not be detected at or above the 20 ng/mL cutoff in any participant at any time after the drinking events. We conclude that after long-term abstinence the cutoff of 20 ng/mL for single alcohol consumption leading to BACs up to 0.63 g/kg is not exceeded., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2023
- Full Text
- View/download PDF
99. [Fire disaster due to deflagration of a propane gas-air mixture].
- Author
-
Nadjem H, Vogt S, Simon KH, Pollak S, Geisenberger D, Kramer L, Pircher R, Perdekampl MG, and Thierauf-Emberger A
- Subjects
- Air, Forensic Medicine methods, Germany, Humans, Blast Injuries pathology, Burns pathology, Explosions classification, Fires, Multiple Trauma pathology, Propane
- Abstract
On 26 Nov 2012, a serious fire occurred at Neustadt/Black Forest in which 14 persons in a sheltered workshop died and 10 other individuals were injured. The fire was caused by the unbridled escape of propane gas due to accidental disconnection of the screw fixing between a gas bottle and a catalytic heater. Deflagration of the propane gas-air mixture set the workshop facilities on fire. In spite of partly extensive burns the fatally injured victims could be rapidly identified. The results of the fire investigations at the scene and the autopsy findings are presented. Carboxyhemoglobin concentrations ranged between 8 and 56 % and signs of fire fume inhalation were present in all cases. Three victims had eardrum ruptures due to the sudden increase in air pressure during the deflagration.
- Published
- 2015
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