2,194 results on '"Testosterone Congeners"'
Search Results
52. Research from First Affiliated Hospital of Anhui Medical University in the Area of Prostatitis Published (Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in...).
- Abstract
A recent study conducted by researchers at the First Affiliated Hospital of Anhui Medical University explores the relationship between insufficient sleep and prostatitis, a condition that affects men's physical and mental health. The study found that sleep deprivation (SD) led to a reduction in dihydrotestosterone and melatonin levels, which triggered the activation of the cGAS-STING pathway and the release of inflammatory cells into the prostatic stroma. The researchers also observed that mice with SD-induced prostatitis experienced relapses when subjected to SD again. This research provides valuable insights into the pathogenesis, therapeutic targets, and prevention strategies of prostatitis. [Extracted from the article]
- Published
- 2024
53. Studies from Second Affiliated Hospital of Guangzhou University of Chinese Medicine Have Provided New Data on Polycystic Ovary Syndrome (Effects of Berberine on glucolipid metabolism among dehydroepiandrosterone-induced rats of polycystic ovary...).
- Abstract
A recent study conducted at the Second Affiliated Hospital of Guangzhou University of Chinese Medicine in China explored the effects of berberine on glucolipid metabolism in rats with polycystic ovary syndrome (PCOS) and insulin resistance (IR). The researchers found that berberine treatment improved insulin sensitivity, reduced abnormal hormone levels, and normalized blood lipid levels in the PCOS-IR rats. Additionally, berberine protected the normal histological structures of the ovaries in these rats. These findings provide new insights into the therapeutic potential of berberine for patients with glucolipid metabolic disturbances associated with PCOS. [Extracted from the article]
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- 2024
54. Anabolic androgenic steroid-induced liver injury: An update
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Ana, Petrovic, Sonja, Vukadin, Renata, Sikora, Kristina, Bojanic, Robert, Smolic, Davor, Plavec, George Y, Wu, and Martina, Smolic
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Anabolic Agents ,Chemical and Drug Induced Liver Injury, Chronic ,Androgens ,Gastroenterology ,Humans ,Testosterone ,Steroids ,Cholestasis ,Fibrosis ,Liver ,Chemical and drug induced liver injury ,General Medicine ,Testosterone Congeners - Abstract
Anabolic androgenic steroids (AASs) are a group of molecules including endogenous testosterone and synthetic derivatives that have both androgenic and anabolic effects. These properties make them therapeutically beneficial in medical conditions such as hypogonadism. However, they are commonly bought illegally and misused for their anabolic, skeletal muscle building, and performance- enhancing effects. Supraphysiologic and long-term use of AASs affects all organs, leading to cardiovascular, neurological, endocrine, gastrointestinal, renal, and hematologic disorders. Hepatotoxicity is one of the major concerns regarding AASs treatment and abuse. Testosterone and its derivatives have been most often shown to induce a specific form of cholestasis, peliosis hepatis, and hepatic benign and malignant tumors. It is currently believed that mechanisms of pathogenesis of these disorders include disturbance of antioxidative factors, upregulation of bile acid synthesis, and induction of hepatocyte hyperplasia. Most toxicity cases are treated with supportive measures and liver function normalizes with discontinuation of AAS. However, some long-term consequences are irreversible. AAS-induced liver injury should be taken in consideration in patients with liver disorders, especially with the increasing unintentional ingestion of supplements containing AAS. In this paper, we review the most current knowledge about AAS-associated adverse effects on the liver, and their clinical presentations, prevalence, and pathophysiological mechanisms.
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- 2022
55. Influence of ethanol consumption and food intake on serum concentrations of endogenous steroids.
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Thieme D, Krumbholz A, Bidlingmaier M, Geffert C, Hameder A, Stöver A, Graw M, and Keiler AM
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- Male, Female, Humans, Androstenedione metabolism, Testosterone Congeners, Ethanol, Adrenocorticotropic Hormone, Eating, Testosterone pharmacology, Steroids metabolism
- Abstract
Steroid biosynthesis and biotransformation are based on a cascade of enzymatic processes being highly sensitive to various external influences. Amongst those, ethanol was shown to affect testosterone metabolism. For doping analyses, athlete steroid profiles comprise seven urinary steroid metabolites, of which relevant ratios are significantly increased following ethanol consumption. This effect is presumably based on the lack of hepatic NAD
+ -coenzyme as a consequence of ethanol oxidation. Only recently, testosterone (T) and androstenedione (A4) blood profiles have been introduced as additional approach for doping control. However, a potential influence of ethanol intake on testosterone biosynthesis and thus on blood steroid profiles has not been investigated so far. Therefore, steroid concentrations from 10 males and 10 females receiving an ethanol infusion up to a breath alcohol concentration of 0.5 mg/L which was hold as a plateau for two hours were conducted. Blood samples were drawn every 15 min for steroid quantification. An ethanol-dependent T/A4 increase up to 385% resulting from A4 suppression was observed in 14 volunteers. In addition, we observed sporadic A4 increases coinciding with cortisol and ACTH pulses pointing to a meal-induced adrenal stimulation. While testosterone levels in males showed diurnal variation solely, testosterone levels in some females were found to be susceptible to ethanol- and ACTH-dependent perturbations, which is thought to be due to its predominant adrenal synthesis in females. In conclusion, the results of the present study emphasize the importance of blood sampling at a sufficient time interval from food and ethanol intake. This is of interest if T and A4 are used for diagnostics in doping control., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)- Published
- 2024
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56. Long-Term Exposure to Supraphysiological Levels of Testosterone Impacts Rat Submandibular Gland Proteome.
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Valente-Santos J, Vitorino R, Sousa-Mendes C, Oliveira P, Colaço B, Faustino-Rocha AI, Neuparth MJ, Leite-Moreira A, Duarte JA, Ferreira R, and Amado F
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- Male, Rats, Animals, Submandibular Gland, Proteomics, Tandem Mass Spectrometry, Rats, Wistar, Testosterone Congeners, Testosterone, Proteome
- Abstract
The salivary glands play a central role in the secretion of saliva, whose composition and volume affect oral and overall health. A lesser-explored dimension encompasses the possible changes in salivary gland proteomes in response to fluctuations in sex hormone levels. This study aimed to examine the effects of chronic exposure to testosterone on salivary gland remodeling, particularly focusing on proteomic adaptations. Therefore, male Wistar rats were implanted with subcutaneous testosterone-releasing devices at 14 weeks of age. Their submandibular glands were histologically and molecularly analyzed 47 weeks later. The results underscored a significant increase in gland mass after testosterone exposure, further supported by histologic evidence of granular duct enlargement. Despite increased circulating sex hormones, there was no detectable shift in the tissue levels of estrogen alpha and androgen receptors. GeLC-MS/MS and subsequent bioinformatics identified 308 proteins in the submandibular glands, 12 of which were modulated by testosterone. Of note was the pronounced upregulation of Klk3 and the downregulation of Klk6 and Klk7 after testosterone exposure. Protein-protein interaction analysis with the androgen receptor suggests that Klk3 is a potential target of androgenic signaling, paralleling previous findings in the prostate. This exploratory analysis sheds light on the response of salivary glands to testosterone exposure, providing proteome-level insights into the associated weight and histological changes.
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- 2023
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57. Innovative Detection of Testosterone Esters in Camel Hair: Unravelling the Mysteries of Dromedary Endocrinology.
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Shah I, Hakeem MK, Alraeesi A, and Barker J
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- Animals, Chromatography, Liquid, Decanoates, Laurates, Tandem Mass Spectrometry, Testosterone Congeners, Benzoates, Esters, Hair, Valerates, Testosterone, Camelus
- Abstract
Introduction: Doping and steroid use represent a serious threat to animal health and can even lead to their untimely and painful death. However, doping is an acute problem in today's animal racing world, particularly in camel racing. Testosterone and its ten esters (benzoate, valerate, isocaproate, hexahydrobenzoate, decanoate, undecanoate, laurate, enanthate, cypionate, and caproate) are of utmost importance, because when they are administered to animals it is difficult to measure them efficiently. The levels of testosterone and its esters in camels and other animals are typically determined using urine and blood tests. The aim of this study was to develop and validate a liquid chromatographic-mass spectrometric (LC-MS/MS) method to determine testosterone esters in camel hair, and to apply the validated method to determine testosterone esters in collected samples. To our knowledge, this is the first report of such research. Results and Discussion: The levels of testosterone and its ten derivatives, along with the cortisol-D4 internal standard, were optimised for LC-MS/MS analysis; however, only testosterone along with its seven esters (namely benzoate, valerate, isocaproate, hexahydrobenzoate, decanoate, undecanoate and laurate) could be validated in camel hair. Only five testosterone esters could be determined in camel hair samples; the concentrations were obtained as 10.5-14.9 pg/mg for valerate (in three camels), 12.5-151.6 pg/mg for hexahydrobenzoate (in six camels), 4.8-32.1 pg/mg for laurate (in five camels), 5.1 pg/mg decanoate (in one camel), and 8.35-169 pg/mg for testosterone (in all 24 camels). Interestingly, the three racing camels displayed high concentrations of testosterone (59.2-169 pg/mg, all three camels), laurate (4.8-14.5 pg/mg, two camels), hexahydrobenzoate (116 pg/mg, one camel), decanoate (5.1 pg/mg, one camel), and valerate (11.7 pg/mg, one camel). Methods: Camel hair samples were collected from 21 non-racing dromedary camels along with three racing camels in Al Ain, UAE; these were decontaminated, pulverised, sonicated, and extracted prior to analysis. An LC-MS/MS method was employed to determine the levels of testosterone esters in the hair samples. Conclusions: This novel camel-hair test procedure is accurate, sensitive, rapid, and robust. The findings reported in this study could be significant to evaluate racing camels for suspected doping offenses. Further controlled testosterone supplementation studies are required to evaluate individual esters' effects on camel health and diseases and on performance enhancement levels. This new hair test could promote further studies in doping control, toxicology, and pharmacology, as well as having other clinical applications relating to camel health, injury, and disease.
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- 2023
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58. Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced maturation of spermatogonial cells from prepubertal mice in vitro is enhanced by testosterone.
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Jorban A, Lunenfeld E, and Huleihel M
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- Male, Animals, Mice, Semen, Testosterone Congeners, Spermatogonia, Methylcellulose, Testosterone pharmacology, Granulocyte-Macrophage Colony-Stimulating Factor pharmacology
- Abstract
Spermatogenesis is the complicated process of sperm generation. During this process, spermatogonial cells proliferate and differentiate via meiotic and post-meiotic stages to produce mature sperm. This process is under the regulation of testicular autocrine/paracrine factors. In addition, endocrine factors are crucial to complete spermatogenesis. We aimed to localize granulocyte-macrophage colony-stimulating factor (GM-CSF) and its receptor (GM-CSFR) in testicular cells and further evaluate its involvement in the development of spermatogenesis in vitro. We isolated cells from seminiferous tubule cells of seven-day-old mice and cultured them in vitro using a methylcellulose culture system (MCS), in the presence of GM-CSF and/or testosterone for four weeks. The cells were then examined for markers of different stages of spermatogenesis by immunofluorescence staining and/or qPCR analyses. Our results revealed the presence of GM-CSF and GM-CSFR in testicular cells (premeiotic and meiotic cells as well as somatic cells; Leydig and Sertoli cells). We further demonstrated the development of colonies/spheroids in the MCS which contained pre-meiotic, meiotic, and post-meiotic cells. The addition of GM-CSF to the MCS significantly increased the percentage of pre-meiotic and meiotic cells compared to control. Furthermore, the addition of GM-CSF and testosterone together significantly increased the percentage of cells in the post-meiotic stage compared to the addition of each separately. In conclusion, our results indicate that testicular cells express GM-CSF/GM-CSFR, and that GM-CSF is involved in the development of different stages of spermatogenesis in vitro. Furthermore, testosterone enhances the development of spermatogenic cells and potentiates the effect of GMCSF on the development of post-meiotic cells. These findings provide evidence that GM-CSF and testosterone are involved in the development of spermatogenesis in vitro and in vivo. In brief: Testicular somatic and germ cells express GM-CSF and GM-CSFR. Our study suggests that testicular GM-CSF is involved in the development of spermatogenesis, which is potentiated by testosterone.
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- 2023
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59. The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine.
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Hunter SK, S Angadi S, Bhargava A, Harper J, Hirschberg AL, D Levine B, L Moreau K, J Nokoff N, Stachenfeld NS, and Bermon S
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- Adult, Humans, Female, Male, United States, Sex Characteristics, Testosterone, Testosterone Congeners, Gonadal Steroid Hormones, Athletic Performance physiology, Sports Medicine
- Abstract
Abstract: Biological sex is a primary determinant of athletic performance because of fundamental sex differences in anatomy and physiology dictated by sex chromosomes and sex hormones. Adult men are typically stronger, more powerful, and faster than women of similar age and training status. Thus, for athletic events and sports relying on endurance, muscle strength, speed, and power, males typically outperform females by 10%-30% depending on the requirements of the event. These sex differences in performance emerge with the onset of puberty and coincide with the increase in endogenous sex steroid hormones, in particular testosterone in males, which increases 30-fold by adulthood, but remains low in females. The primary goal of this consensus statement is to provide the latest scientific knowledge and mechanisms for the sex differences in athletic performance. This review highlights the differences in anatomy and physiology between males and females that are primary determinants of the sex differences in athletic performance and in response to exercise training, and the role of sex steroid hormones (particularly testosterone and estradiol). We also identify historical and nonphysiological factors that influence the sex differences in performance. Finally, we identify gaps in the knowledge of sex differences in athletic performance and the underlying mechanisms, providing substantial opportunities for high-impact studies. A major step toward closing the knowledge gap is to include more and equitable numbers of women to that of men in mechanistic studies that determine any of the sex differences in response to an acute bout of exercise, exercise training, and athletic performance., (Copyright © 2023 by the American College of Sports Medicine.)
- Published
- 2023
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60. Iodine Intake and Testosterone.
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Barbonetti A, Castellini C, Di Giulio F, Antolini F, Tienforti D, Muselli M, and Baroni MG
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- Humans, Testosterone Congeners, Nutritional Status, Testosterone, Iodine
- Published
- 2023
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61. Evaluation of alternative gas chromatographic and mass spectrometric behaviour of trimethylsilyl-derivatives of non-hydrolysed sulfated anabolic steroids.
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Albertsdóttir AD, Van Gansbeke W, Van Eenoo P, and Polet M
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- Anabolic Androgenic Steroids, Sulfates metabolism, Testosterone Congeners, Steroids analysis, Substance Abuse Detection methods, Anabolic Agents analysis, Doping in Sports
- Abstract
Sulfated metabolites have shown to have potential as long-term markers (LTMs) of anabolic-androgenic steroid (AAS) abuse. The compatibility of gas chromatography-mass spectrometry (GC-MS) with trimethylsilyl (TMS)-derivatives of non-hydrolysed sulfated steroids has been demonstrated, where, after derivatisation, generally, two closely eluting isomers are formed that both have the same molecular ion [M-H
2 SO4 ]•+ . Sulfated reference standards are in limited commercial availability, and therefore, the current knowledge of the GC-MS behaviour of these compounds is mainly based on sulfating and analysing the available standard reference material. This procedure can unfortunately not cover all of the current known LTMs as these are often not available as pure substance. Therefore, in theory, some metabolites could be missed as they exhibit alternative behaviour. To investigate the matter, in-house sulfated reference materials that bear resemblance to known sulfated LTMs were analysed on GC-MS in their TMS-derivatised non-hydrolysed state. The (alternative) gas chromatographic and mass spectrometric behaviour was mapped, evaluated and linked to the corresponding steroid structures. Afterwards, using fraction collection, known sulfated LTMs were isolated from excretion urine to confirm the observed findings. The categories that were selected were mono-hydroxy-diones, 17-methyl-3,17-diols and 17-keto-3,16-diols as these are commonly encountered AAS conformations. The ability to predict the GC-MS behaviour of non-hydrolysed sulfated AAS metabolites is the corner stone of finding new metabolites. This knowledge is also essential, for example, for understanding AAS detection analyses, for the mass spectrometric characterization of metabolites of new designer steroids or when one needs to characterize an unknown steroid structure., (© 2023 John Wiley & Sons Ltd.)- Published
- 2023
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62. The HEAT-Registry (HEmatopoietic Affection by Testosterone): comparison of a transdermal gel vs long-acting intramuscular testosterone undecanoate in hypogonadal men
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Michael, Zitzmann, Jann F, Cremers, Claudia, Krallmann, and Sabine, Kliesch
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Male ,Hot Temperature ,Receptors, Androgen ,Hypogonadism ,Humans ,Testosterone ,Obesity ,Prospective Studies ,Registries ,Geriatrics and Gerontology ,Injections, Intramuscular ,Testosterone Congeners ,Aged - Abstract
Testosterone (T) therapy of hypogonadal men requires stable kinetics, tolerance and attenuation of symptoms. Both intramuscular injections of the long-acting ester T undecanoate (TU) and transdermal application of T gel offer a proven efficacy. As T has marked effects on hematopoiesis, an elevation of hematocrit has to be considered during T therapy.To compare the effects of a transdermal T gel with long-acting intramuscular TU on hematopoiesis, controlling for age, diagnosis, androgen receptor susceptibility and obesity.Prospective two-arm open registry, minimum duration of 26 weeks per patient. Putative modulators of erythropoiesis entering regression models were type of medication, type of hypogonadism, delta of total testosterone concentrations, waist circumference, age as well as (in a sub-group) androgen receptor gene CAG repeat length.Tertiary university based andrological outpatient department.802 hypogonadal men, 498 receiving T gel and 304 receiving intramuscular TU, median age 40 years (interquartile range = 25).Follow-up visits after initiation of treatment occurred between treatment weeks 26-30. Serum T concentrations increased markedly in both patient groups. Men receiving intramuscular TU exhibited an increased hematocrit (50%) to a significantly higher amount than men receiving T gel (69/304 vs. 25/498,T substitution with intramuscular TU or T gel increase T concentrations effectively. Long-acting TU leads to a higher rate of hematocrit levels50%, whilst at the same time it seems to be more efficient to ameliorate anemia in the subgroup of respectively affected hypogonadal patients . This applies especially to obese older men with functional hypogonadism.
- Published
- 2022
63. Body Image Disorders and Anabolic Steroid Withdrawal Hypogonadism in Men
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Harrison G, Pope and Gen, Kanayama
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Male ,Anabolic Agents ,Endocrinology ,Substance-Related Disorders ,Hypogonadism ,Endocrinology, Diabetes and Metabolism ,Testis ,Humans ,Body Dysmorphic Disorders ,Testosterone Congeners - Abstract
Hypogonadism commonly occurs during withdrawal from anabolic-androgenic steroid (AAS) use, particularly when users have been taking AAS for prolonged periods. Mounting evidence now suggests that AAS-induced hypogonadism may persist for months or even years after last AAS use, and in some cases may be partially or completely irreversible. Treatment with human chorionic gonadotropin and clomiphene may help to restore hypothalamic-pituitary-testicular axis function, and these substances are widely used illicitly by AAS users at the end of a course of AAS as so-called postcycle therapy. Many endocrinologists still have only limited experience in diagnosing and treating AAS-induced hypogonadism.
- Published
- 2022
64. No association between psychiatric symptoms and doses of anabolic steroids in a cohort of male and female bodybuilders
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Julio X. Amaral, Andrea C. Deslandes, Monica C. Padilha, Leonardo Vieira Neto, Luiz E. Osorio, Francisco Radler Aquino Neto, and Marcelo S. Cruz
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Male ,Anabolic Agents ,Sleep Initiation and Maintenance Disorders ,Androgens ,Humans ,Pharmaceutical Science ,Environmental Chemistry ,Female ,Steroids ,Testosterone Congeners ,Androstanes ,Spectroscopy ,Analytical Chemistry - Abstract
The use of androgenic-anabolic steroids (AAS) can be associated with psychiatric symptoms such as insomnia, anxiety and increased aggressiveness. Although dose-dependent effects have been observed in some controlled studies, this association is not always seen in the ecological use of AAS. This study utilized WADA's steroid profile of suspicious use of AAS, urinary detection of AAS metabolites and measurement of sexual hormones to confirm recent use of AAS in a cohort of 103 bodybuilders (75 males, 28 females). The majority of participants (61.2%) presented symptoms of agitation, insomnia, increased aggressiveness or depression in the last 3 months. About one-third of participants presented scores on the HAM-A anxiety scale equivalent to moderate to severe symptoms of anxiety. A minority of participants (12.6%) presented high to moderate scores on the BPQ aggressiveness scale. The majority of participants (73.8%) presented hyperthymic temperament in the BRIEF-TEMPS scale. There was no significant difference in the presence of psychiatric symptoms between males and females and no association between psychiatric symptoms and estimated weekly doses of AAS. A negative association was observed between scores on the BPQ scale (verbal aggression, anger and total score) and the time of AAS use. We discuss differences of AAS use between male and female bodybuilders and the screening of AAS use in the general population. Our findings highlight the importance of mental health awareness among people using AAS.
- Published
- 2022
65. From a non‐targeted metabolomics approach to a targeted biomarkers strategy to highlight testosterone abuse in equine. Illustration of a methodological transfer between platforms and laboratories
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Chloé Cloteau, Gaud Dervilly, Zied Kaabia, Florian Bagilet, Vivian Delcourt, Benoit Loup, Yann Guitton, Anne‐Lise Royer, Fabrice Monteau, Patrice Garcia, Marie‐Agnès Popot, Bruno Le Bizec, and Ludovic Bailly‐Chouriberry
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Doping in Sports ,Animals ,Metabolomics ,Pharmaceutical Science ,Environmental Chemistry ,Steroids ,Testosterone ,Horses ,Laboratories ,Testosterone Congeners ,Biomarkers ,Spectroscopy ,Analytical Chemistry - Abstract
In order to overcome the challenge associated with the screening of Anabolic-Androgenic Steroids abuses in animal competitions, a non-targeted liquid chromatography coupled to high resolution mass spectrometry based metabolomics approach was implemented on equine urine samples to highlight potential biomarkers associated with the administration of such compounds, using testosterone esters as model steroids. A statistical model relying on four potential biomarkers intensity could be defined to predict the status of the samples. With a routine application perspective, the monitoring of the highlighted potential biomarkers was first transferred into high-throughput liquid chromatography-selected reaction monitoring (LC-SRM). The model's performances and robustness of the approach were preserved and providing a first demonstration of metabolomics-based biomarkers integration within a targeted workflow using common benchtop MS instrumentation. In addition, with a view to the widespread implementation of such biomarker-based tools, we have transferred the method to a second laboratory with similar instrumentation. This proof of concept allows the development and application of biomarker-based strategies to meet current doping control needs.
- Published
- 2022
66. Research from Monash University Provides New Study Findings on Testosterone Congeners (Associations between blood concentrations of sex hormones and physical function in community-dwelling older women: a prospective cohort study).
- Subjects
SEX hormones ,PHYSICAL mobility ,OLDER women ,TESTOSTERONE ,LONGITUDINAL method - Abstract
A study conducted by researchers at Monash University in Australia examined the associations between blood concentrations of sex hormones and physical function in community-dwelling older women. The study found that higher concentrations of testosterone and dehydroepiandrosterone were associated with less decline in grip strength and self-reported physical function in women aged over 70 years. The researchers suggest that further studies are needed to determine if testosterone and dehydroepiandrosterone therapy can prevent functional decline in this at-risk group. The study was published in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. [Extracted from the article]
- Published
- 2024
67. Study Findings on Anabolic Agents Detailed by Researchers at University of Leon [Online information and availability of three doping substances (anabolic agents) in sports: role of pharmacies].
- Abstract
A study conducted by researchers at the University of Leon in Spain examined the availability and information on the internet regarding the sale of three doping substances: oxandrolone, DHEA, and androstenedione. The study found that these substances are easily accessible online without a prescription, and the majority of websites selling them are not pharmacies. The researchers recommend that these products be sold through pharmacies to ensure quality and provide evidence-based information on their safe use, benefits, and risks. They also suggest that athletes consult health professionals for guidance on suitable supplements for their training and sports objectives. [Extracted from the article]
- Published
- 2023
68. Report Summarizes Prostate Cancer Study Findings from University of Valencia (Plasma Androstenedione Concentration Can Discriminate Frail versus Non-Frail Men with Prostate Cancer under Androgen Deprivation Therapy).
- Abstract
A recent study conducted by researchers at the University of Valencia in Spain explored the association between androgen deprivation therapy (ADT) and functional status and psychological alterations in patients with prostate cancer. The study found that high concentrations of androstenedione were significantly associated with frailty syndrome in both localized and metastatic prostate cancer patients receiving ADT. However, there were no significant relationships between the concentration of androgens in plasma and sleep quality, cognitive functions, or symptoms of depression. The researchers suggest that further investigation into the role of androstenedione as a biomarker for frailty syndrome in prostate cancer patients is needed. [Extracted from the article]
- Published
- 2023
69. Mohammed VI University Hospital Center Researchers Have Published New Data on Testosterone Congeners (Efficacy of Transdermal Dihydrotestosterone and Testosterone Enanthate for Penile Augmentation in Patients With Idiopathic Micropenis: A...).
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Researchers at Mohammed VI University Hospital Center in Oujda, Morocco have conducted a study comparing the efficacy of transdermal dihydrotestosterone and testosterone enanthate in treating idiopathic micropenis. The study involved 49 patients with idiopathic micropenis, with one group receiving transdermal dihydrotestosterone and the other group receiving testosterone enanthate. The results showed that transdermal dihydrotestosterone was superior to injectable exogenous testosterone in increasing penile size. No side effects were detected in either group. The study provides valuable insights into the treatment of idiopathic micropenis. [Extracted from the article]
- Published
- 2023
70. Reports Summarize Testosterone Congeners Research from Monash University (Effect of dehydroepiandrosterone therapy on cognitive performance among postmenopausal women: a systematic review of randomized clinical trial data).
- Subjects
CLINICAL trials ,COGNITIVE ability ,POSTMENOPAUSE ,TESTOSTERONE ,DEHYDROEPIANDROSTERONE ,LIBIDO - Abstract
A systematic review conducted by researchers at Monash University in Australia evaluated the effect of dehydroepiandrosterone (DHEA) therapy on cognitive performance in postmenopausal women. The review analyzed randomized clinical trial data and found that overall, DHEA therapy did not have a beneficial effect on cognitive performance in postmenopausal women. The review identified four studies that met the inclusion criteria, and while one study showed a positive outcome in visual-spatial performance, this effect was not observed in the other studies. The researchers concluded that the heterogeneity of study designs and the high risk of bias in multiple domains limited the ability to conduct a meta-analysis and make between-study comparisons. This information is important for individuals considering DHEA supplementation for cognitive decline and dementia prevention. [Extracted from the article]
- Published
- 2023
71. New Testosterone Congeners Study Results Reported from University of Texas San Antonio (Synthesis of 6β-hydroxy Androgens From a 3,5-diene Steroid Precursor To Test for Cytochrome P450 3a4-catalyzed Hydroxylation of Androstenedione).
- Abstract
Keywords: San Antonio; State:Texas; United States; North and Central America; 17-Ketosteroids; Androstenedione; Cytochromes; Drugs and Therapies; Gonadal Hormones; Hemeproteins; Proteins; Testosterone Congeners EN San Antonio State:Texas United States North and Central America 17-Ketosteroids Androstenedione Cytochromes Drugs and Therapies Gonadal Hormones Hemeproteins Proteins Testosterone Congeners 1941 1941 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Drugs and Therapies - Testosterone Congeners have been published. San Antonio, State:Texas, United States, North and Central America, 17-Ketosteroids, Androstenedione, Cytochromes, Drugs and Therapies, Gonadal Hormones, Hemeproteins, Proteins, Testosterone Congeners. [Extracted from the article]
- Published
- 2023
72. Reports Outline Regenerative Medicine Study Results from Sun Yat-sen University (Adipose-derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone On Hair Follicle Growth By Activating Wnt/β-catenin Pathway).
- Abstract
According to the news reporters, the research concluded: "Additionally, we discovered that ADSC-Exos increased Ser9 phosphorylated glycogen synthase kinase-3 beta levels and facilitated nuclear translocation of beta-catenin, which may have been blocked by the specific Wnt/beta-catenin signaling pathway inhibitor dickkopf-related protein 1. Keywords: Guangzhou; People's Republic of China; Asia; Alopecia; Armadillo Domain Proteins; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Catenins; Cytoplasmic Structures; Dihydrotestosterone; Drugs and Therapies; Exosomes; Gonadal Hormones; Hair Diseases and Conditions; Health and Medicine; Hypotrichosis; Organelles; Proteins; Regenerative Medicine; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Stem Cell Research; Testosterone Congeners; Transcription Factors; Transport Vesicles; beta Catenin EN Guangzhou People's Republic of China Asia Alopecia Armadillo Domain Proteins Bioengineering Biomedical Engineering Biomedicine Biotechnology Catenins Cytoplasmic Structures Dihydrotestosterone Drugs and Therapies Exosomes Gonadal Hormones Hair Diseases and Conditions Health and Medicine Hypotrichosis Organelles Proteins Regenerative Medicine Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Stem Cell Research Testosterone Congeners Transcription Factors Transport Vesicles beta Catenin 411 411 1 11/06/23 20231109 NES 231109 2023 NOV 9 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- New research on Biomedical Engineering - Regenerative Medicine is the subject of a report. [Extracted from the article]
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- 2023
73. A new oral testosterone (TLANDO) treatment regimen without dose titration requirement for male hypogonadism
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Anthony, DelConte, Kongnara, Papangkorn, Kilyoung, Kim, Benjamin J, Bruno, Nachiappan, Chidambaram, Mohit, Khera, Irwin, Goldstein, Tobias S, Kohler, Martin, Miner, Adrian S, Dobs, and Mahesh V, Patel
- Subjects
Male ,Endocrinology ,Reproductive Medicine ,Hormone Replacement Therapy ,Hypogonadism ,Urology ,Endocrinology, Diabetes and Metabolism ,Humans ,Eunuchism ,Testosterone ,Middle Aged ,Testosterone Congeners - Abstract
Male hypogonadism (testosterone level 300 ng/dl) is a clinical syndrome that results from failure of the testis to produce physiological levels of testosterone. Most marketed testosterone replacement therapy products often require multiple dose adjustment clinic visits to achieve the desired, eugonadal testosterone levels.To evaluate the efficacy and safety of a novel oral testosterone undecanoate therapy for the treatment of hypogonadism.Ninety-five (N = 95) hypogonadal men were enrolled in this open-label, single-arm, multicenter study in the United States (NCT03242590). Subjects received 225 mg of oral testosterone undecanoate (TLANDO) twice a day for 24 days without dose adjustment. Primary efficacy was percentages of subjects who achieved mean 24-h testosterone levels within the eugonadal range and secondary efficacies were evaluated based on the upper limit of lab normal range of testosterone concentration.Subjects enrolled were on average age of 56 years, with about 17% of subjects older than 65 years. The mean body mass index was 32.8 kg/mTLANDO restored testosterone levels to the normal range in the majority of hypogonadal males. This new oral testosterone replacement therapy can provide an option for no-titration oral testosterone replacement therapy. This therapy has the potential to improve patient compliance in testosterone replacement therapy.
- Published
- 2022
74. Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
- Author
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Ane Arrizabalaga-Larrañaga, Paul W. Zoontjes, Johan J. P. Lasaroms, Michel W. F. Nielen, and Marco H. Blokland
- Subjects
Atmospheric solids analysis probe ,Mass spectrometry ,Programme and Account Management ,Ambient ionization ,On-site testing ,Organic Chemistry ,Transportable MS ,Esters ,Biochemistry ,Organische Chemie ,Analytical Chemistry ,Anabolic Agents ,Team Growth Promotors ,Steroids ,Testosterone Congeners ,VLAG - Abstract
Due to the absence of chromatographic separation, ambient ionization mass spectrometry had the potential to improve the throughput of control laboratories in the last decades and will soon be an excellent approach for on-site use as well. In this study, an atmospheric solids analysis probe (ASAP) with a single quadrupole mass analyzer has been evaluated to identify anabolic steroid esters rapidly. Sample introduction, applied scan time, and probe temperature were optimized for sensitivity. The in-source fragmentations of seventeen selected steroid esters, commonly found in illicit samples, were determined by applying different cone voltages (12, 20, 30, and 40 V). A spectral library was created for these steroid esters based on the four stages of in-source fragmentation spectra. The applicability of this method was demonstrated for the rapid identification of steroid esters in oily injection solutions, providing test results in less than 2 min. Graphical abstract
- Published
- 2022
75. Development of a Standardized Microflow LC Gradient to Enable Sensitive and Long-Term Detection of Synthetic Anabolic-Androgenic Steroids for High-Throughput Doping Controls
- Author
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Marie-Agnès Popot, Vivian Delcourt, Isabelle Pottier, Patrice Garcia, Agnès Barnabé, Nasrine Mansoibou, Nicolai Bache, Yohan Glavieux, Benoit Loup, Benjamin Chabot, François Andre, Isabelle Perot, and Ludovic Bailly-Chouriberry
- Subjects
Doping in Sports ,Chromatography ,Microdosing ,Elution ,Chemistry ,Anabolic-Androgenic Steroids ,Analytical Chemistry ,Substance Abuse Detection ,Anabolic Agents ,Metabolomics ,Tandem Mass Spectrometry ,medicine ,Animals ,Steroids ,Horses ,Testosterone Congeners ,Stanozolol ,medicine.drug - Abstract
Synthetic androgenic anabolic steroids (AAS) are banned compounds and considered as major threats by both racing and sports international authorities. Hence, doping control laboratories are continually looking into analytical improvements to increase their detection capabilities, notably by means of emerging technologies. To enhance analytical performances for the detection of synthetic AAS such as stanozolol, specific chromatographic procedures have been developed using recent quaternary liquid chromatography technology originally designed for high-throughput standardized proteomics connected to mass spectrometry. Applying the newly designed elution procedures described in this paper to the analyses of stanozolol and its metabolites in complex matrixes revealed improved sensitivity compared to previously described high-throughput methods. Indeed, we report the consistent and reliable detection of 16β-hydroxy-stanozolol down to 10 pg/mL in equine urine and being detectable up-to 3 months after a microdosing administration. Furthermore, a five months long elimination of stanozolol and its metabolites could be monitored on horse mane sections after a single dose administration. Our work highlights novel solutions to detect AAS with improved sensitivity. The application of such developments constitutes new landmarks for doping control laboratories and could be extended to other targeted compounds in residue analysis, toxicology, and metabolomics. Based on this work, the developed chromatographic method is now freely available within the Evosep Plus program.
- Published
- 2021
76. Fake anabolic androgenic steroids on the black market – a systematic review and meta-analysis on qualitative and quantitative analytical results found within the literature
- Author
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Magnolini, Raphael, Falcato, Luis, Cremonesi, Alessio, Schori, Dominique, Bruggmann, Philip, University of Zurich, and Magnolini, Raphael
- Subjects
Europe ,10036 Medical Clinic ,Environmental and Occupational Health ,Public Health, Environmental and Occupational Health ,Humans ,Steroids ,610 Medicine & health ,2739 Public Health, Environmental and Occupational Health ,Public Health ,Testosterone Congeners - Abstract
Objective Supraphysiologic doses of anabolic androgenic steroids (AAS) are widely used to improve body image and sport performance goals. These substances can easily be acquired over the internet, leading to a substantial black market. We reviewed literature that assessed the quality and quantity of AAS found on the black market. Methods We searched PubMed/Medline, Embase and Google Scholar for articles published before March 2022. Additional hand searches were conducted to obtain studies not found in the primary literature search. Studies were included if they report on qualitative and/or quantitative analytical findings of AAS from the black market. Primary outcomes were proportions of counterfeit or substandard AAS. Eligible articles were extracted; quality appraisal was done using the ToxRTool for in-vitro studies. We used random-effects models to calculate the overall mean estimates for outcomes. The review protocol has been published and registered in INPLASY. Results Overall, 19 studies, which in total comprised 5,413 anabolic samples, met the inclusion criteria, and passed the quality appraisal from two WHO world regions that reported findings, the Americas and Europe. Most studies were nonclinical laboratory studies (95%) and provided samples seized by authorities (74%). In 18 articles, proportions of counterfeit substances and in eight articles, proportions of substandard substances were presented. The overall mean estimate for counterfeit anabolic steroids found on the black market was 36% (95% CI = 29, 43). An additional 37% (95% CI = 17, 63) were of substandard quality. We also demonstrate that these drugs could contain no active ingredient, or in another amount than that labeled, a wrong active ingredient, as well as not all or more active ingredients than were labeled. High heterogeneity among all analyses and significant differences between geographical subgroups were found. Conclusion With this systematic review and meta-analysis, we demonstrate that substantial mean proportions of black-market AAS are counterfeit and of substandard quality. These products pose a considerable individual and public health threat, and the very wide range in proportions of fake black-market AAS puts the user in a situation of unpredictable uncertainty. There is a great need for future prevention and harm-reduction programs to protect users from these substances.
- Published
- 2022
77. The effects of anabolic-androgenic steroids on DNA damage in bodybuilders’ blood lymphocytes
- Author
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Jafar Hajavi, Mojtaba Kianmehr, Abbasali Abbasnezhad, Mohamad Ghorbani, Miad Mahdavi, Mahmoud Reza Motaghy, and Mohammad Sohrabi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Anabolism ,DNA damage ,Health, Toxicology and Mutagenesis ,Clinical Biochemistry ,Pilot Projects ,Biochemistry ,Young Adult ,Anabolic Agents ,Internal medicine ,medicine ,Humans ,Tail moment ,Lymphocytes ,Testosterone Congeners ,business.industry ,Significant difference ,Resistance Training ,DNA ,Anabolic-Androgenic Steroids ,Comet assay ,Endocrinology ,Blood pressure ,Microscopy, Fluorescence ,Case-Control Studies ,Androgens ,Comet Assay ,business ,DNA Damage - Abstract
Background Nowadays bodybuilders use anabolic steroids frequently. Abuse of these substances can cause significant side effects; therefore, we aim to investigate the effect of anabolic steroids on DNA damage in bodybuilders’ blood lymphocytes.Methods and materials This case-control study was performed on 36 male bodybuilders in Gonabad. The case group included bodybuilders with a history of taking anabolic-androgenic steroids (n = 18), and the control group composed of bodybuilders who did not use anabolic-androgenic steroids (n = 18). Intravenous blood samples were obtained and then the lymphocytes, cells and electrophoresis of blood were extracted. Afterward, the coloured slides and DNA damage were measured using a fluorescent microscope and CometScore software. The DNA damage was compared using t-tests .Results Results showed that there was no significant difference between age, marital status, BMI, systolic and diastolic blood pressure in the case and control group. However, parameters related to the DNA damage including tail length, percent tail DNA, and tail moment were significantly higher in the case group.Conclusion The use of anabolic-androgenic steroids increases DNA damage in the bodybuilders’ blood lymphocytes.
- Published
- 2021
78. Testosterone Replacement in Men With Hypogonadism and Effects on Anemia-Blood, Sex, and Aging.
- Author
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Alibhai SMH
- Subjects
- Male, Humans, Testosterone therapeutic use, Aging, Testosterone Congeners, Hypogonadism drug therapy, Anemia drug therapy, Anemia etiology
- Published
- 2023
- Full Text
- View/download PDF
79. Testosterone treatment: who will benefit the most?
- Author
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Deng L and Shi Q
- Subjects
- Humans, Androgens therapeutic use, Testosterone Congeners, Testosterone adverse effects, Hypogonadism
- Abstract
Competing Interests: We declare no competing interests.
- Published
- 2023
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- View/download PDF
80. AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3β,17β-Diol.
- Author
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Detlefsen AJ, Mesaros CA, Duan L, and Penning TM
- Subjects
- Male, Humans, Testosterone Congeners, Androstenes, Dehydroepiandrosterone Sulfate, Aldo-Keto Reductase Family 1 Member C3, Testosterone pharmacology, Prostatic Neoplasms drug therapy
- Abstract
Androgen receptor signaling inhibitors (ARSI) are used to treat castration-resistant prostate cancer (CRPC) to stop a resurgence of androgen receptor (AR) signaling. Despite early success, patients on ARSIs eventually relapse, develop drug resistance, and succumb to the disease. Resistance may occur through intratumoral steroidogenesis mediated by upregulation of aldo-keto reductase family 1C member 3 (AKR1C3). Patients treated with leuprolide (castrate) and those treated with leuprolide plus abiraterone (post-Abi) harbor a reservoir of DHEA-S which could fuel testosterone (T) biosynthesis via AKR1C3 to cause a resurgence of prostate cancer cell growth. We demonstrate that concentrations of DHEA-S found in castrate and post-Abi patients are (i) converted to T in an AKR1C3-dependent manner in prostate cancer cells, and (ii) in amounts sufficient to stimulate AKR1C3-dependent cell growth. We observed this in primary and metastatic prostate cancer cell lines, CWR22PC and DuCaP, respectively. Androgen measurements were made by stable isotope dilution LC-MS/MS. We demonstrate AKR1C3 dependence using stable short hairpin RNA knockdown and pharmacologic inhibitors. We also demonstrate that free DHEA is reduced to 5-androstene-3β,17β-diol (5-Adiol) by AKR1C3 and that this is a major metabolite, suggesting that in our cell lines 5-Adiol is a predominant precursor of T. We have identified a mechanism of ARSI resistance common to both primary and metastatic cell lines that is dependent on the conversion of DHEA to 5-Adiol on route to T catalyzed by AKR1C3., Significance: We show that reservoirs of DHEA-S that remain after ARSI treatment are converted into T in primary and metastatic prostate cancer cells in amounts sufficient to stimulate cell growth. Pharmacologic and genetic approaches demonstrate that AKR1C3 is required for these effects. Furthermore, the route to T proceeds through 5-Adiol. We propose that this is a mechanism of ARSI drug resistance., (© 2023 The Authors; Published by the American Association for Cancer Research.)
- Published
- 2023
- Full Text
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81. Early Access to Testosterone Therapy in Transgender and Gender-Diverse Adults Seeking Masculinization: A Randomized Clinical Trial.
- Author
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Nolan BJ, Zwickl S, Locke P, Zajac JD, and Cheung AS
- Subjects
- Adult, Humans, Young Adult, Testosterone therapeutic use, Testosterone Congeners, Ambulatory Care Facilities, Australia, Transgender Persons
- Abstract
Importance: Testosterone treatment is a necessary component of care for some transgender and gender-diverse individuals. Observational studies have reported associations between commencement of gender-affirming hormone therapy and improvements in gender dysphoria and depression, but there is a lack of data from randomized clinical trials., Objective: To assess the effect of testosterone therapy compared with no treatment on gender dysphoria, depression, and suicidality in transgender and gender-diverse adults seeking masculinization., Design, Setting, and Participants: A 3-month open-label randomized clinical trial was conducted at endocrinology outpatient clinics and primary care clinics specializing in transgender and gender-diverse health in Melbourne, Australia, from November 1, 2021, to July 22, 2022. Participants included transgender and gender-diverse adults aged 18 to 70 years seeking initiation of testosterone therapy., Interventions: Immediate initiation of testosterone commencement (intervention group) or no treatment (standard care waiting list of 3 months before commencement). This design ensured no individuals would be waiting longer than the time to standard care., Main Outcomes and Measures: The primary outcome was gender dysphoria, as measured by the Gender Preoccupation and Stability Questionnaire. Secondary outcomes included the Patient Health Questionnaire-9 (PHQ-9) to assess depression and the Suicidal Ideation Attributes Scale (SIDAS) to assess suicidality. Questionnaires were undertaken at 0 and 3 months. The evaluable cohort was analyzed., Results: Sixty-four transgender and gender-diverse adults (median [IQR] age, 22.5 [20-27] years) were randomized. Compared with standard care, the intervention group had a decrease in gender dysphoria (mean difference, -7.2 points; 95% CI, -8.3 to -6.1 points; P < .001), a clinically significant decrease in depression (ie, change in score of 5 points on PHQ-9; mean difference, -5.6 points; 95% CI, -6.8 to -4.4 points; P < .001), and a significant decrease in suicidality (mean difference in SIDAS score, -6.5 points; 95% CI, -8.2 to -4.8 points; P < .001). Resolution of suicidality assessed by PHQ-9 item 9 occurred in 11 individuals (52%) with immediate testosterone commencement compared with 1 (5%) receiving standard care (P = .002). Seven individuals reported injection site pain/discomfort and 1 individual reported a transient headache 24 hours following intramuscular administration of testosterone undecanoate. No individual developed polycythemia., Conclusions and Relevance: In this open-label randomized clinical trial of testosterone therapy in transgender and gender-diverse adults, immediate testosterone compared with no treatment significantly reduced gender dysphoria, depression, and suicidality in transgender and gender-diverse individuals desiring testosterone therapy., Trial Registration: ANZCTR Identifier: ACTRN1262100016864.
- Published
- 2023
- Full Text
- View/download PDF
82. Total testosterone cut-off value indicating androgen-secreting tumor in premenopausal women with hirsutism.
- Author
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Güneş M, Güneş E, and Öztürk F
- Subjects
- Humans, Female, Adolescent, Adult, Androgens, Hirsutism diagnosis, Testosterone Congeners, Testosterone, Neoplasms
- Abstract
Objective: There is insufficient data on which cut-off value must be used to measure the increase in total testosterone (TT) compared to the upper limit of normal (CULN) in the diagnosis of androgen-secreting tumor (ASTM) in female individuals with premenopausal hirsutism (FIPH)., Patients and Methods: A total of 413 FIPH over 18 years of age who were admitted to the endocrinology clinic between May 2013 and 30 April 2018 were eligible for the study. Hormone profiles of the participants in the follicular phase and other information were obtained from their files. The androgen suppression ratio (ASR) was analyzed after 48 hours of low-dose dexamethasone suppression test (LDDST) in those whose TT CULN (nmol/L) increased two-fold., Results: Idiopathic hirsutism was found in 193 participants (46.73%) and polycystic ovary syndrome (PCOS) in 200 (48.43%) and other sources of hirsutism; non-classical congenital adrenal hyperplasia (NCCAH) in 10 patients (2.42%), hyperprolactinemia in 6 patients (1.45%), ASTM of ovarian origin in 2 patients (0.48%), Cushing's disease in 1 patient (0.24%), and adrenal ASTM in 1 patient (0.24%). A cut-off value of two-fold CULN increase for TT sensitivity of 100% and a specificity of 99.5% in indicating an ASTM source, and ASR above 49% in LDDST sensitivity of 80% and a specificity of 100% in excluding an ASTM source, was used., Conclusions: At the TT level, a two-fold increase CULN in FIPH indicates an ASTM source. In addition, ASR after LDDST is a useful parameter in the exclusion of ASTM sources in the same patient population.
- Published
- 2023
- Full Text
- View/download PDF
83. Hair analysis as a powerful tool for the identification of anabolic androgenic steroids and other performance and image enhancing drugs in a subject with tissues damages.
- Author
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Odoardi S, Mestria S, Biosa G, Cittadini F, Senati M, and Strano Rossi S
- Subjects
- Hair Analysis, Androgens, Steroids, Testosterone Congeners, Anabolic Androgenic Steroids, Anabolic Agents
- Published
- 2023
- Full Text
- View/download PDF
84. Non-linear association between testosterone and LDL concentrations in men.
- Author
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Lee JH, Jung HD, Choi JD, Kang JY, Yoo TK, and Park YW
- Subjects
- Male, Humans, Cross-Sectional Studies, Triglycerides, Cholesterol, LDL, Testosterone, Testosterone Congeners
- Abstract
Background: Contradictory data have been reported about the association between testosterone levels and the levels of low-density lipoprotein cholesterol (LDL)., Objectives: The aim of this study was to elucidate the association between testosterone and LDL levels., Materials and Methods: A cross-sectional study was conducted that included 7268 men who had participated in a health examination. Men who took agents that influence serum lipid profiles within the previous 6 months were excluded. A full metabolic work-up and serum testosterone level checks were performed. The main outcome measures included the testosterone level and testosterone <3.5 ng/ml prevalence of each decile of LDL and their polynomial trendlines and the odds ratio (OR) of testosterone <3.5 ng/ml according to the LDL level., Results: The polynomial trendline suggests the inverse association of testosterone with the deciles of triglycerides, the positive association of testosterone with the deciles of high-density lipoprotein cholesterol and the inverted U-shaped association between testosterone and the deciles of LDL. The polynomial trendline suggests a U-shaped curvilinear relationship between the deciles of LDL and the prevalence of testosterone <3.5 ng/ml. The adjusted ORs of testosterone <3.5 ng/ml in men in the lowest and highest deciles were significantly higher than those of men in the 10th-90th deciles of LDL (OR [95% CI], < 10th LDL: 1.4[1.2-1.8]; 10th - 90th LDL: 1.0 [reference]; >90th LDL: 1.3[1.0-1.6]), which reinforces the U-shaped curvilinear relationship between LDL levels and the prevalence of testosterone <3.5 ng/ml., Discussion and Conclusion: Further research is needed to elucidate the association of very low or very high LDL concentrations with circulating testosterone in men., (© 2023 American Society of Andrology and European Academy of Andrology.)
- Published
- 2023
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85. Development of a Rapid, Targeted LC-IM-MS Method for Anabolic Steroids.
- Author
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Wedge A, Hoover M, Pettit-Bacovin T, Aderorho R, Efird E, and Chouinard CD
- Subjects
- Humans, Chromatography, High Pressure Liquid methods, Reproducibility of Results, Mass Spectrometry methods, Steroids analysis, Anabolic Androgenic Steroids, Testosterone Congeners
- Abstract
Anabolic steroids are of high biological interest due to their involvement in human development and disease progression. Additionally, they are banned in sport due to their performance-enhancing characteristics. Analytical challenges associated with their measurement stem from structural heterogeneity, poor ionization efficiency, and low natural abundance. Their importance in a variety of clinically relevant assays has prompted the consideration of integrating ion mobility spectrometry (IMS) into existing LC-MS assays, due primarily to its speed and structure-based separation capability. Herein we have optimized a rapid (2 min) targeted LC-IM-MS method for the detection and quantification of 40 anabolic steroids and their metabolites. First, a steroid-specific calibrant mixture was developed to cover the full range of retention time, mobility, and accurate mass. Importantly, this use of this calibrant mixture provided robust and reproducible measurements based on collision cross section (CCS) with interday reproducibility of <0.5%. Furthermore, the combined separation power of LC coupled to IM provided comprehensive differentiation of isomers/isobars within 6 different isobaric groups. Multiplexed IM acquisition also provided improved limits of detection, which were well below 1 ng/mL in almost all compounds measured. This method was also capable of steroid profiling, providing quantitative ratios (e.g., testosterone/epitestosterone, androsterone/etiocholanolone, etc.). Lastly, phase II steroid metabolites were probed in lieu of hydrolysis to demonstrate the ability to separate those analytes and provide information beyond total steroid concentration. This method has tremendous potential for rapid analysis of steroid profiles in human urine spanning a variety of applications from developmental disorders to doping in sport.
- Published
- 2023
- Full Text
- View/download PDF
86. Testosterone and lifespan in males: At the right time and the right level
- Author
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Lishi Wang, Heliang Yin, and Weikuan Gu
- Subjects
Male ,Endocrinology ,Urology ,Longevity ,Humans ,Testosterone ,General Medicine ,Testosterone Congeners - Published
- 2022
87. Screening method for the characterization of anabolic steroids seized in Brazil using paper spray mass spectrometry and chemometric tools
- Author
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Ana Gabriella Carvalho Miguita, Rodinei Augusti, Clésia Cristina Nascentes, and Marcelo Martins Sena
- Subjects
Principal Component Analysis ,Anabolic Agents ,Chemometrics ,Testosterone Congeners ,Spectroscopy ,Brazil ,Mass Spectrometry - Abstract
This paper reports the use of paper spray mass spectrometry (PS-MS) combined with chemometric models to analyze seized samples of anabolic steroids. Because many forensic laboratories typically demand high-throughput analysis for this type of sample, we developed a quicker and simpler alternative analytical method for routine analysis with minimal sample preparation. Oily samples (n = 39) resulting from seizures carried out by Brazilian Federal and State Police units were selected for this study. These samples were analyzed by PS-MS in the positive ion mode and full scan (50-1000 m/z), providing spectra containing patterns of the respective active ingredients present in each product. A principal component analysis (PCA) model was built, which discriminated samples mainly according to their active ingredients and allowed to detect and characterize some cases of product counterfeiting. The variable selection method ordered predictors selection was employed jointly with PCA to improve sample cluster separation and to provide model simplification. The final PCA model was built with three principal components and using only 28 spectral variables. This model accounted for 69.82% of the variance and discriminated samples according to their specific active ingredients.
- Published
- 2022
88. Colonic Angioectasia in an Adolescent Boy with Hoyeraal-Hreidarsson on Long-Term Anabolic Steroid Therapy.
- Author
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Khalaf, Racha and Cuffari, Carmen
- Subjects
- *
ANABOLIC steroids , *TEENAGE boys , *BONE marrow transplantation , *MYELODYSPLASTIC syndromes , *DEVELOPMENTAL delay - Abstract
Androgen therapy has proven efficacy in treating patients with bone marrow failure who are not candidates for bone marrow transplantation. Herein, we report on a case of colonic angioectasia secondary to oxymetholone use in an adolescent patient with Hoyeraal-Hreidarsson syndrome (HHS). A 13-year-old Caucasian male with HHS characterized by cerebellar hypoplasia, developmental delay, microcephaly, esophageal strictures and myelodysplasia presented with severe hematochezia from colonic angioectasia secondary to long-term oxymetholone therapy. These vascular lesions resolved spontaneously once this anabolic steroid was discontinued. While androgen therapy is often recommended for certain anemias and myelodysplastic syndromes, clinicians should be aware of the potential complication in developing these perceived uncommon colonic angioectasias. Moreover, pediatric gastroenterologists should familiarize themselves in identifying these vascular lesions by colonoscopy, especially among the high risk groups on long-term anabolic steroid therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
89. Investigations in carbon isotope ratios of seized testosterone and boldenone preparations
- Author
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Thomas Piper and Mario Thevis
- Subjects
Doping in Sports ,Carbon Isotopes ,Chromatography ,Isotope ,Chemistry ,medicine.medical_treatment ,Epitestosterone ,Pharmaceutical Science ,Boldenone ,Gas Chromatography-Mass Spectrometry ,Analytical Chemistry ,Steroid ,Substance Abuse Detection ,Endogenous steroids ,Isotopes of carbon ,medicine ,Environmental Chemistry ,Testosterone ,Isotope-ratio mass spectrometry ,Testosterone Congeners ,Spectroscopy ,medicine.drug - Abstract
In order to detect the misuse of testosterone (T) or boldenone (Bo) in doping control analysis, the confirmation of atypical findings employing the determination of carbon isotope ratios (CIR) is mandatory for issuing adverse analytical findings. Elevated concentrations of T (or elevated T/epitestosterone ratios) may result from confounding factors such as ethanol intake, and the presence of low urinary concentrations of Bo can originate from endogenous or urinary in situ production of small amounts of the steroid. As pharmaceutical preparations of Bo and T are generally depleted in 13 C, their CIR differ significantly from the 13 C-enriched endogenous steroids. Some rare cases have been reported on pharmaceutical preparations showing 13 C-enriched isotope ratios that complicate the current application of CIR in sports drug testing. Therefore, the CIR of a subset of n = 157 T preparations and n = 39 Bo preparations seized in Switzerland and Germany between 2013 and 2018 was analyzed in order to estimate the possible impact of steroid preparations showing 13 C-enriched isotope ratios on the current approach to detect their misuse. All investigated Bo preparations showed CIR in the expected range between - 26.7 and -30.3‰. Within the T samples, 95% showed the expected values below -26‰ while six samples fall between -25 and -26‰ and one sample was indistinguishable from endogenously produced T with a CIR of -23.3‰.
- Published
- 2021
90. Carbon isotope ratios of endogenous steroids found in human serum—method development, validation, and reference population-derived thresholds
- Author
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Eberhard Nieschlag, Lia Bally, Hans Geyer, Mario Thevis, and Thomas Piper
- Subjects
Male ,Serum ,Hormone Replacement Therapy ,030303 biophysics ,Population ,610 Medicine & health ,Urine ,Epiandrosterone ,Proof of Concept Study ,01 natural sciences ,Biochemistry ,Gas Chromatography-Mass Spectrometry ,Analytical Chemistry ,03 medical and health sciences ,chemistry.chemical_compound ,Dehydroepiandrosterone sulfate ,Limit of Detection ,Reference Values ,Doping controls ,medicine ,Humans ,Testosterone ,Multi-dimensional gas chromatography ,Isotope-ratio mass spectrometry ,education ,Testosterone Congeners ,Carbon Isotopes ,0303 health sciences ,education.field_of_study ,Chromatography ,Androsterone ,010401 analytical chemistry ,Epitestosterone ,Assay sensitivity ,IRMS ,Carbon isotope ratios ,0104 chemical sciences ,chemistry ,Female ,Steroids ,Research Paper ,medicine.drug - Abstract
In order to detect the misuse of testosterone (T), urinary steroid concentrations and concentration ratios are quantified and monitored in a longitudinal manner to enable the identification of samples exhibiting atypical test results. These suspicious samples are then forwarded to isotope ratio mass spectrometry (IRMS)–based methods for confirmation. Especially concentration ratios like T over epitestosterone (E) or 5α-androstanediol over E proved to be valuable markers. Unfortunately, depending on the UGT2B17 genotype and/or the gender of the athlete, these markers may fail to provide evidence for T administrations when focusing exclusively on urine samples. In recent years, the potential of plasma steroids has been investigated and were found to be suitable to detect T administrations especially in female volunteers. A current drawback of this approach is the missing possibility to confirm that elevated steroid concentrations are solely derived from an administration of T and cannot be attributed to confounding factors. Therefore, an IRMS method for plasma steroids was developed and validated taking into account the comparably limited sample volume. As endogenous reference compounds, unconjugated cholesterol and dehydroepiandrosterone sulfate were found suitable, while androsterone and epiandrosterone (both sulfo-conjugated) were chosen as target analytes. The developed method is based on multi-dimensional gas chromatography coupled to IRMS in order to optimize the overall assay sensitivity. The approach was validated, and a reference population encompassing n = 65 males and females was investigated to calculate population-based thresholds. As proof-of-concept, samples from volunteers receiving T replacement therapies and excretion study samples were investigated. Graphical abstract
- Published
- 2021
91. Undeclared Doping Substances are Highly Prevalent in Commercial Sports Nutrition Supplements
- Author
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Luc J. C. van Loon, Willem Koert, Laila Spruijt, Erik Duiven, Olivier M. de Hon, Humane Biologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Physiotherapy, Human Physiology and Anatomy, and Human Physiology and Sports Physiotherapy Research Group
- Subjects
elite sport ,health risks ,Methylhexaneamine ,01 natural sciences ,chemistry.chemical_compound ,0302 clinical medicine ,ANABOLIC-ANDROGENIC STEROIDS ,Tetrahydroisoquinolines ,Prevalence ,Medicine ,doping violation ,URINE ,Orthopedics and Sports Medicine ,Significant risk ,DRUG ,Testosterone Congeners ,Doping in Sports ,Adrenergic beta-Agonists ,Drug Contamination ,Fat loss ,RC1200-1245 ,Sports ,Research Article ,HEPATOTOXICITY ,Adrenergic beta-Antagonists ,Physical Therapy, Sports Therapy and Rehabilitation ,3-DIMETHYLAMYLAMINE ,Muscle mass ,Sports nutrition ,Risk Assessment ,spiking ,dietary supplements ,03 medical and health sciences ,Alkaloids ,STRYCHNINE ,Contamination ,Environmental health ,Humans ,PHENETHYLAMINES ,business.industry ,010401 analytical chemistry ,Amphetamines ,prohibited substances ,030229 sport sciences ,0104 chemical sciences ,1,3-DIMETHYLAMYLAMINE ,Androstadienes ,METABOLITE ,chemistry ,Unintentional doping ,GV557-1198.995 ,Sports medicine ,General health ,Boldione ,business ,human activities ,DIETARY-SUPPLEMENTS ,INGESTION - Abstract
Sports nutrition supplements have previously been reported to contain undeclared doping substances. The use of such supplements can lead to general health risks and may give rise to unintentional doping violations in elite sports. To assess the prevalence of doping substances in a range of high-risk sports nutrition supplements available from Dutch web shops. A total of 66 sports nutrition supplements - identified as potentially high-risk products claiming to modulate hormone regulation, stimulate muscle mass gain, increase fat loss, and/or boost energy - were selected from 21 different brands and purchased from 17 web shops. All products were analyzed for doping substances by the UK life sciences testing company LGC, formerly known as the Laboratory of the Government Chemist, using an extended version of their ISO17025 accredited nutritional supplement screen. A total of 25 out of the 66 products (38%) contained undeclared doping substances, which included high levels of the stimulants oxilofrine, beta-methylphenethylamine (BMPEA) and N,beta-dimethylphenethylamine (NBDMPEA), the stimulant 4-methylhexan-2-amine (methylhexaneamine, 1,3-dimethylamylamine, DMAA), the anabolic steroids boldione (1,4-androstadiene-3,17-dione) and 5-androstene-3 beta,17 alpha-diol (17 alpha-AED), the beta-2 agonist higenamine and the beta-blocker bisoprolol. Based upon the recommended dose and the potential variability of analyte concentration, the ingestion of some products identified within this study could pose a significant risk of unintentional doping violations. In addition to inadvertent doping risks, the prescribed use of 3 products (4.5%) could likely impose general health risks.
- Published
- 2021
92. Long‐term stability study and evaluation of intact steroid conjugate ratios after the administration of endogenous steroids
- Author
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Peter Van Eenoo, Pieter Van Renterghem, and Laurie De Wilde
- Subjects
Male ,Anabolism ,medicine.medical_treatment ,Pharmaceutical Science ,Dehydroepiandrosterone ,Endogeny ,Pharmacology ,01 natural sciences ,Analytical Chemistry ,Steroid ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Humans ,Environmental Chemistry ,Testosterone ,030216 legal & forensic medicine ,Testosterone Congeners ,Volunteer ,Spectroscopy ,Doping in Sports ,Sulfates ,Chemistry ,010401 analytical chemistry ,Dihydrotestosterone ,Glucuronic acid ,0104 chemical sciences ,Substance Abuse Detection ,Steroids ,medicine.drug - Abstract
The most frequently detected substances prohibited by the World Anti-Doping Agency (WADA) belong to the anabolic steroids class. The most challenging compounds among this class are the endogenous anabolic steroids, which are detected by quantitative measurement of testosterone (T) and its metabolites with a so-called "steroid profiling" method. The current steroid profile is based on the concentrations and ratios of the sum of free and glucuronidated steroids. Recently, our group developed a steroid profiling method for the detection of three free steroids and 14 intact steroid conjugates, including both the glucuronic acid conjugated and sulfated fraction. The study aimed at evaluating the long-term stability of steroid conjugate concentrations and ratios, and the influence of different endogenous steroids on this extended steroid profile. A single dose of oral T undecanoate (TU), topical T gel, topical dihydrotestosterone (DHT) gel, and oral dehydroepiandrosterone (DHEA) was administered to six healthy male volunteers. One additional volunteer with a homozygote deletion of the UGT2B17 gene (del/del genotype) received a single topical dose of T gel. An intramuscular dose of TU was administered to another volunteer. To avoid fluctuation of steroid concentrations caused by variations in urinary flow rates, steroid ratios were calculated and evaluated as possible biomarkers for the detection of endogenous steroid abuse with low doses. Overall, sulfates do not have substantial additional value in prolonging detection times for the investigated endogenous steroids and administration doses. The already monitored glucuronides were overall the best markers and were sufficient to detect the administered steroids.
- Published
- 2021
93. Cancer cachexia: molecular mechanism and pharmacological management
- Author
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Yanjun Mi, Ting Huang, Zhengzhi Zou, Yonghua Li, Huan Jin, and Yibing Chen
- Subjects
Cachexia ,Anti-Inflammatory Agents ,Appetite Stimulants ,Adipose tissue ,Antineoplastic Agents ,Anorexia ,Bioinformatics ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,Weight loss ,Neoplasms ,Weight Loss ,Humans ,Medicine ,Muscle, Skeletal ,Testosterone Congeners ,Molecular Biology ,Wasting ,Fatigue ,030304 developmental biology ,0303 health sciences ,business.industry ,Mechanism (biology) ,digestive, oral, and skin physiology ,Cell Biology ,musculoskeletal system ,medicine.disease ,Survival Analysis ,Muscle atrophy ,Mitochondria ,Muscular Atrophy ,Adipose Tissue ,030220 oncology & carcinogenesis ,Quality of Life ,medicine.symptom ,business - Abstract
Cancer cachexia often occurs in malignant tumors and is a multifactorial and complex symptom characterized by wasting of skeletal muscle and adipose tissue, resulting in weight loss, poor life quality and shorter survival. The pathogenic mechanism of cancer cachexia is complex, involving a variety of molecular substrates and signal pathways. Advancements in understanding the molecular mechanisms of cancer cachexia have provided a platform for the development of new targeted therapies. Although recent outcomes of early-phase trials have showed that several drugs presented an ideal curative effect, monotherapy cannot be entirely satisfactory in the treatment of cachexia-associated symptoms due to its complex and multifactorial pathogenesis. Therefore, the lack of definitive therapeutic strategies for cancer cachexia emphasizes the need to develop a better understanding of the underlying mechanisms. Increasing evidences show that the progression of cachexia is associated with metabolic alternations, which mainly include excessive energy expenditure, increased proteolysis and mitochondrial dysfunction. In this review, we provided an overview of the key mechanisms of cancer cachexia, with a major focus on muscle atrophy, adipose tissue wasting, anorexia and fatigue and updated the latest progress of pharmacological management of cancer cachexia, thereby further advancing the interventions that can counteract cancer cachexia.
- Published
- 2021
94. Harm Reduction in Male Patients Actively Using Anabolic Androgenic Steroids (AAS) and Performance-Enhancing Drugs (PEDs): a Review
- Author
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Alex K Bonnecaze, Thomas O'Connor, and Cynthia Burns
- Subjects
Male ,Infertility ,medicine.medical_specialty ,Substance-Related Disorders ,MEDLINE ,Performance-Enhancing Substances ,Review ,01 natural sciences ,03 medical and health sciences ,Anabolic Agents ,0302 clinical medicine ,Harm Reduction ,Internal Medicine ,Humans ,Medicine ,030212 general & internal medicine ,0101 mathematics ,Intensive care medicine ,Testosterone Congeners ,Depression (differential diagnoses) ,Harm reduction ,business.industry ,010102 general mathematics ,Anhedonia ,medicine.disease ,Sexual dysfunction ,Steroids ,medicine.symptom ,business ,Dyslipidemia ,Patient education - Abstract
Anabolic androgenic steroid (AAS) and performance-enhancing drug (PED) use is a prevalent medical issue, especially among men, with an estimated 2.9–4 million Americans using AAS in their lifetime. Prior studies of AAS use reveal an association with polycythemia, dyslipidemia, infertility, hypertension, left ventricular hypertrophy, and multiple behavioral disorders. AAS withdrawal syndrome, a state of depression, anhedonia, and sexual dysfunction after discontinuing AAS use, is a common barrier to successful cessation. Clinical resources for these patients and training of physicians on management of the patient using AAS are limited. Many men are hesitant to seek traditional medical care due to fear of judgment and lack of confidence in physician knowledge base regarding AAS. While proposed approaches to weaning patients off AAS are published, guidance on harm reduction for actively using patients remains sparse. Medical education regarding the management of AAS use disorder is paramount to improving care of this currently underserved patient population. Management of these patients must be non-judgmental and focus on patient education, harm reduction, and support for cessation. The approach to harm reduction should be guided by the specific AAS/PEDs used.
- Published
- 2021
95. Patent Issued for Composition, containing Quisqualis indica extract, for preventing or treating prostatic hyperplasia (USPTO 11771726).
- Subjects
PROSTATE hypertrophy ,JUVENILE diseases ,PATENTS ,GENITOURINARY diseases - Abstract
The method according to claim 1, wherein the Quisqualis indica extract has effects on the reduction of prostate weight, dihydrotestosterone (DHT) that is a factor causing prostatic hyperplasia, and prostate epithelial hyperplasia. Keywords: Dihydrotestosterone; Drugs and Therapies; Gonadal Hormones; Health and Medicine; Male Urogenital Diseases and Conditions; Men's Health; Pediatrics; Prostate Gland; Prostatic Diseases and Conditions; Prostatic Hyperplasia; Testosterone Congeners; The Industry & Academic Cooperation in Chungnam National University; Urogenital Diseases and Conditions EN Dihydrotestosterone Drugs and Therapies Gonadal Hormones Health and Medicine Male Urogenital Diseases and Conditions Men's Health Pediatrics Prostate Gland Prostatic Diseases and Conditions Prostatic Hyperplasia Testosterone Congeners The Industry & Academic Cooperation in Chungnam National University Urogenital Diseases and Conditions 3357 3357 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- The Industry & Academic Cooperation in Chungnam National University (Daejeon, South Korea) has been issued patent number 11771726, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors. It is known that one mechanism of prostatic hyperplasia is related to male hormones, testosterone and dihydrotestosterone (DHT). [Extracted from the article]
- Published
- 2023
96. New Data from National Hellenic Research Foundation Illuminate Research in Testosterone Congeners (A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in...).
- Abstract
ResultsAmong the novel derivatives, six were able to selectively protect PC12 cells through interaction with the TrkA receptor and five more to selectively protect TrkB-expressing cells via interaction with the TrkB receptor. 17-Ketosteroids, Chromaffin System, Dehydroepiandrosterone, Dehydroepiandrosterone Therapy, Chromaffin Cells, Drugs and Therapies, Gonadal Hormones, Testosterone Congeners, PC12 Cells Keywords: 17-Ketosteroids; Chromaffin Cells; Chromaffin System; Dehydroepiandrosterone; Dehydroepiandrosterone Therapy; Drugs and Therapies; Gonadal Hormones; PC12 Cells; Testosterone Congeners EN 17-Ketosteroids Chromaffin Cells Chromaffin System Dehydroepiandrosterone Dehydroepiandrosterone Therapy Drugs and Therapies Gonadal Hormones PC12 Cells Testosterone Congeners 1156 1156 1 10/16/23 20231020 NES 231020 2023 OCT 20 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in testosterone congeners. [Extracted from the article]
- Published
- 2023
97. Researcher at Third Affiliated Hospital of Sun Yat-Sen University Reports Research in Regenerative Medicine (Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating...).
- Abstract
Keywords: Alopecia; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Cytoplasmic Structures; Dihydrotestosterone; Drugs and Therapies; Exosomes; Gonadal Hormones; Hair Diseases and Conditions; Health and Medicine; Hypotrichosis; Organelles; Regenerative Medicine; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Stem Cell Research; Testosterone Congeners; Transport Vesicles EN Alopecia Bioengineering Biomedical Engineering Biomedicine Biotechnology Cytoplasmic Structures Dihydrotestosterone Drugs and Therapies Exosomes Gonadal Hormones Hair Diseases and Conditions Health and Medicine Hypotrichosis Organelles Regenerative Medicine Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Stem Cell Research Testosterone Congeners Transport Vesicles 390 390 1 10/16/23 20231016 NES 231016 2023 OCT 19 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- New research on regenerative medicine is the subject of a new report. This research using human hair follicle organs, in vitro dermal papilla cells, and in vivo animal models showed that ADSC-Exos not only encouraged healthy hair growth but also counteracted the inhibitory effects of DHT on hair growth.". [Extracted from the article]
- Published
- 2023
98. Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome.
- Abstract
17-Ketosteroids, Adnexal Diseases and Conditions, Androstenedione, Anterior Pituitary Hormones, Clinical Research, Clinical Trials and Studies, Corpus Luteum Hormones, Diet and Nutrition, Drugs and Therapies, Endocrine Research, Endocrine System Diseases and Conditions, Endocrine System Diseases and Conditions - Polycystic Ovary Syndrome, Enzymes and Coenzymes, Estradiol Congeners, Estrone, Estrone Therapy, Female Urogenital Diseases and Conditions, Glucose Metabolism Disorders, Gonadal Disorders, Gonadal Hormones, Health and Medicine, Hormones, Hyperinsulinism, Insulin Resistance, Nutritional and Metabolic Diseases and Conditions, Obstetrics, Ovarian Cysts, Ovarian Diseases and Conditions, Peptide Hormones, Peptide Proteins, Pharmaceuticals, Pituitary Gonadotropins, Polycystic Ovary Syndrome, Progesterone, Progesterone Congeners, Proinsulin, Prolactin, Reproductive Health, Syndromes, Testosterone Congeners, Therapy, Women's Health. [Extracted from the article]
- Published
- 2023
99. Reports on Hypertension Findings from Kaiser Permanente Oakland Medical Center Provide New Insights (Elevated Serum Androstenedione Level in a Patient With Ectopic Adrenocorticotropic Hormone Syndrome).
- Subjects
ECTOPIC hormones ,ADRENOCORTICOTROPIC hormone ,NERVE tissue proteins ,PEPTIDE hormones ,ANDROSTENEDIONE ,HYPOKALEMIA - Abstract
Keywords: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormones; Androgens; Androstenedione; Cardiovascular Diseases and Conditions; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Drugs and Therapies; Gonadal Hormones; Health and Medicine; Hypertension; Hypothalamic Hormones; Melanocortins; Nerve Tissue Proteins; Neuropeptides; Peptide Hormones; Peptide Proteins; Pituitary Hormones; Pro-Opiomelanocortin; Testosterone Congeners EN 17-Ketosteroids Adrenal Cortex Hormones Adrenocorticotropic Hormones Androgens Androstenedione Cardiovascular Diseases and Conditions Dehydroepiandrosterone Dehydroepiandrosterone Sulfate Drugs and Therapies Gonadal Hormones Health and Medicine Hypertension Hypothalamic Hormones Melanocortins Nerve Tissue Proteins Neuropeptides Peptide Hormones Peptide Proteins Pituitary Hormones Pro-Opiomelanocortin Testosterone Congeners 560 560 1 10/03/23 20231003 NES 231003 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on hypertension. According to the news reporters, the research concluded: "Adrenal androgen assessment may help differentiate pituitary versus ectopic ACTH secretion in which androstenedione is elevated, but studies are needed to determine whether disproportionate androstenedione elevation reliably predicts the origin of ACTH excess.". [Extracted from the article]
- Published
- 2023
100. Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Nandrolone Decanoate Therapy and Therapy With Complex Physiotherapy and Diet in the Treatment of Sarcopenia.
- Subjects
NANDROLONE ,SARCOPENIA ,TREADMILL exercise ,NEUROLOGICAL disorders ,BONE densitometry ,SPINAL muscular atrophy ,PHYSICAL therapy ,INHALATION injuries ,CELIAC disease - Abstract
Age and Ageing Diseases and Conditions, Clinical Research, Clinical Trials and Studies, Drugs and Therapies, Gonadal Hormones, Health and Medicine, Muscular Atrophy, Musculoskeletal Diseases and Conditions, Musculoskeletal Diseases and Conditions - Muscular Atrophy, Nandrolone, Nandrolone Decanoate Therapy, Nervous System Diseases and Conditions, Neurologic Manifestations, Neuromuscular Manifestations, Pharmaceuticals, Pharmacotherapy, Placebos, Rehabilitation, Rheumatology, Sarcopenia, Testosterone Congeners, Intramuscular Injections, Therapy. [Extracted from the article]
- Published
- 2023
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