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51. Genetic Evaluation of A Nation-Wide Dutch Pediatric DCM Cohort: The Use of Genetic Testing in Risk Stratification

Author

Circulatory Health, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, Genetica Klinische Genetica, Onderzoek Precision medicine, Genetica, van der Meulen, Marijke H, Herkert, Johanna C, den Boer, Susanna L, du Marchie Sarvaas, Gideon J, Blom, Nico, Ten Harkel, Arend D J, Breur, Hans M P J, Rammeloo, Lukas A J, Tanke, Ronald, Marcelis, Carlo, van de Laar, Ingrid M B H, Verhagen, Judith M A, Lekanne Dit Deprez, Ronald H, Barge-Schaapveld, Daniela Q C M, Baas, Annette, Sammani, Arjan, Christiaans, Imke, van Tintelen, J Peter, Dalinghaus, Michiel, Circulatory Health, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, Genetica Klinische Genetica, Onderzoek Precision medicine, Genetica, van der Meulen, Marijke H, Herkert, Johanna C, den Boer, Susanna L, du Marchie Sarvaas, Gideon J, Blom, Nico, Ten Harkel, Arend D J, Breur, Hans M P J, Rammeloo, Lukas A J, Tanke, Ronald, Marcelis, Carlo, van de Laar, Ingrid M B H, Verhagen, Judith M A, Lekanne Dit Deprez, Ronald H, Barge-Schaapveld, Daniela Q C M, Baas, Annette, Sammani, Arjan, Christiaans, Imke, van Tintelen, J Peter, and Dalinghaus, Michiel

Published
2022

53. Mechanism of right precordial ST-segment elevation in structural heart disease: Excitation failure by current-to-load mismatch

Author

Hoogendijk, Mark G., Potse, Mark, Linnenbank, André C., Verkerk, Arie O., den Ruijter, Hester M., van Amersfoorth, Shirley C.M., Klaver, Eva C., Beekman, Leander, Bezzina, Connie R., Postema, Pieter G., Tan, Hanno L., Reimer, Annette G., van der Wal, Allard C., ten Harkel, Arend D.J., Dalinghaus, Michiel, Vinet, Alain, Wilde, Arthur A.M., de Bakker, Jacques M.T., and Coronel, Ruben

Published
2010
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57. Deficient Myocardial Organization and Pathological Fibrosis in Fetal Aortic Stenosis—Association of Prenatal Ultrasound with Postmortem Histology

Author

Zwanenburg, Fleur, primary, DeRuiter, Marco C., additional, Wisse, Lambertus J., additional, van Munsteren, Conny J., additional, Bartelings, Margot M., additional, Goumans, Marie-Jose, additional, Ten Harkel, Arend D. J., additional, Jongbloed, Monique R. M., additional, and Haak, Monique C., additional

Published
2021
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61. Associations between blood biomarkers, cardiac function, and adverse outcome in a young fontan cohort

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, van den Bosch, Eva, Bossers, Sjoerd S.M., Kamphuis, Vivian P., Boersma, Eric, Roos-Hesselink, Jolien W., Breur, Johannes M.P.J., Ten Harkel, Arend D.J., Kapusta, Livia, Bartelds, Beatrijs, Roest, Arno A.W., Kuipers, Irene M., Blom, Nico A., Koopman, Laurens P., Helbing, Willem A., Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, van den Bosch, Eva, Bossers, Sjoerd S.M., Kamphuis, Vivian P., Boersma, Eric, Roos-Hesselink, Jolien W., Breur, Johannes M.P.J., Ten Harkel, Arend D.J., Kapusta, Livia, Bartelds, Beatrijs, Roest, Arno A.W., Kuipers, Irene M., Blom, Nico A., Koopman, Laurens P., and Helbing, Willem A.

Published
2021

62. Predicting outcome in children with dilated cardiomyopathy: the use of repeated measurements of risk factors for outcome

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, van der Meulen, Marijke, den Boer, Susanna, du Marchie Sarvaas, Gideon J., Blom, Nico, ten Harkel, Arend D.J., Breur, Hans M.P.J., Rammeloo, Lukas A.J., Tanke, Ronald, Bogers, Ad J.J.C., Helbing, Willem A., Boersma, Eric, Dalinghaus, Michiel, Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, van der Meulen, Marijke, den Boer, Susanna, du Marchie Sarvaas, Gideon J., Blom, Nico, ten Harkel, Arend D.J., Breur, Hans M.P.J., Rammeloo, Lukas A.J., Tanke, Ronald, Bogers, Ad J.J.C., Helbing, Willem A., Boersma, Eric, and Dalinghaus, Michiel

Published
2021

63. Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI

Author

Zandstra, Tjitske E., primary, Jongbloed, Monique R. M., additional, Widya, Ralph L., additional, ten Harkel, Arend D. J., additional, Holman, Eduard R., additional, Mertens, Bart J. A., additional, Vliegen, Hubert W., additional, Egorova, Anastasia D., additional, Schalij, Martin J., additional, and Kiès, Philippine, additional

Published
2021
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64. Associations Between Blood Biomarkers, Cardiac Function, and Adverse Outcome in a Young Fontan Cohort

Author

van den Bosch, Eva, primary, Bossers, Sjoerd S. M., additional, Kamphuis, Vivian P., additional, Boersma, Eric, additional, Roos‐Hesselink, Jolien W., additional, Breur, Johannes M. P. J., additional, Ten Harkel, Arend D. J., additional, Kapusta, Livia, additional, Bartelds, Beatrijs, additional, Roest, Arno A. W., additional, Kuipers, Irene M., additional, Blom, Nico A., additional, Koopman, Laurens P., additional, and Helbing, Willem A., additional

Published
2021
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67. Maturation of the Cardiac Autonomic Nervous System Activity in Children and Adolescents

Author

Harteveld, Lisette M., primary, Nederend, Ineke, additional, ten Harkel, Arend D. J., additional, Schutte, Nienke M., additional, de Rooij, Susanne R., additional, Vrijkotte, Tanja G. M., additional, Oldenhof, Helena, additional, Popma, Arne, additional, Jansen, Lucres M. C., additional, Suurland, Jill, additional, Swaab, Hanna, additional, de Geus, Eco J. C., additional, Prätzlich, Martin, additional, Ackermann, Katharina, additional, Baker, Rosalind, additional, Batchelor, Molly, additional, Baumann, Sarah, additional, Bernhard, Anka, additional, Clanton, Roberta, additional, Dikeos, Dimitris, additional, Dochnal, Roberta, additional, Fehlbaum, Lynn Valérie, additional, Fernández‐Rivas, Aranzazu, additional, Gonzalez, Karen, additional, González de Artaza‐Lavesa, Maider, additional, Guijarro, Silvina, additional, Gundlach, Malou, additional, Herpertz‐Dahlmann, Beate, additional, Hervas, Amaia, additional, Kersten, Linda, additional, Kohls, Gregor, additional, Konsta, Angeliki, additional, Lazaratou, Helen, additional, Kerexeta‐Lizeaga, Iñaki, additional, Martinelli, Anne, additional, van Nimwegen, Tisse, additional, Puzzo, Ignazio, additional, Raschle, Nora Maria, additional, Rogers, Jack, additional, Siklósi, Réka, additional, Smaragdi, Areti, additional, Steppan, Martin, additional, De Brito, Stephane, additional, Fairchild, Graeme, additional, Kieser, Meinhard, additional, Konrad, Kerstin, additional, Freitag, Christine, additional, and Stadler, Christina, additional

Published
2021
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68. Predicting outcome in children with dilated cardiomyopathy: the use of repeated measurements of risk factors for outcome

Author

van der Meulen, Marijke, primary, den Boer, Susanna, additional, du Marchie Sarvaas, Gideon J., additional, Blom, Nico, additional, ten Harkel, Arend D.J., additional, Breur, Hans M.P.J., additional, Rammeloo, Lukas A.J., additional, Tanke, Ronald, additional, Bogers, Ad J.J.C., additional, Helbing, Willem A., additional, Boersma, Eric, additional, and Dalinghaus, Michiel, additional

Published
2021
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72. Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiologie patientenzorg, van der Meulen, Marijke H, Boer, Susanna den, du Marchie Sarvaas, Gideon J, Blom, Nico A, Ten Harkel, Arend D J, Breur, Hans M P J, Rammeloo, Lukas A J, Tanke, Ronald, Helbing, Willem A, Boersma, Eric, Dalinghaus, Michiel, Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiologie patientenzorg, van der Meulen, Marijke H, Boer, Susanna den, du Marchie Sarvaas, Gideon J, Blom, Nico A, Ten Harkel, Arend D J, Breur, Hans M P J, Rammeloo, Lukas A J, Tanke, Ronald, Helbing, Willem A, Boersma, Eric, and Dalinghaus, Michiel

Published
2020

73. Emotional and behavioral problems in children with dilated cardiomyopathy

Author

Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, van der Mheen, Malindi, van der Meulen, Marijke H., den Boer, Susanna L., Schreutelkamp, Dayenne J., van der Ende, Jan, de Nijs, Pieter F.A., Breur, Johannes M.P.J., Tanke, Ronald B., Blom, Nico A., Rammeloo, Lukas A.J., ten Harkel, Arend D.J., du Marchie Sarvaas, Gideon J., Utens, Elisabeth M.W.J., Dalinghaus, Michiel, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, van der Mheen, Malindi, van der Meulen, Marijke H., den Boer, Susanna L., Schreutelkamp, Dayenne J., van der Ende, Jan, de Nijs, Pieter F.A., Breur, Johannes M.P.J., Tanke, Ronald B., Blom, Nico A., Rammeloo, Lukas A.J., ten Harkel, Arend D.J., du Marchie Sarvaas, Gideon J., Utens, Elisabeth M.W.J., and Dalinghaus, Michiel

Published
2020

75. Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?

Author

van der Meulen, Marijke H., primary, Boer, Susanna den, additional, du Marchie Sarvaas, Gideon J., additional, Blom, Nico A., additional, ten Harkel, Arend D. J., additional, Breur, Hans M. P. J., additional, Rammeloo, Lukas A. J., additional, Tanke, Ronald, additional, Helbing, Willem A., additional, Boersma, Eric, additional, and Dalinghaus, Michiel, additional

Published
2019
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76. Emotional and behavioral problems in children with dilated cardiomyopathy

Author

van der Mheen, Malindi, primary, van der Meulen, Marijke H, additional, den Boer, Susanna L, additional, Schreutelkamp, Dayenne J, additional, van der Ende, Jan, additional, de Nijs, Pieter FA, additional, Breur, Johannes MPJ, additional, Tanke, Ronald B, additional, Blom, Nico A, additional, Rammeloo, Lukas AJ, additional, ten Harkel, Arend DJ, additional, du Marchie Sarvaas, Gideon J, additional, Utens, Elisabeth MWJ, additional, and Dalinghaus, Michiel, additional

Published
2019
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77. Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation

Author

van der Palen, Roel L F, primary, van der Bom, Teun, additional, Dekker, Annika, additional, Tsonaka, Roula, additional, van Geloven, Nan, additional, Kuipers, Irene M, additional, Konings, Thelma C, additional, Rammeloo, Lukas A J, additional, Ten Harkel, Arend D J, additional, Jongbloed, Monique R M, additional, Koolbergen, Dave R, additional, Mulder, Barbara J M, additional, Hazekamp, Mark G, additional, and Blom, Nico A, additional

Published
2019
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80. Correction: Putting genome-wide sequencing in neonates into perspective

Author

Genetica Klinische Genetica, Cancer, van der Sluijs, Pleuntje J., Aten, Emmelien, Barge-Schaapveld, Daniela Q.C.M., Bijlsma, Emilia K., Bökenkamp-Gramann, Regina, Kaat, Laura Donker, van Doorn, Remco, van de Putte, Dietje Fransen, van Haeringen, Arie, ten Harkel, Arend D.J., Hilhorst-Hofstee, Yvonne, Hoffer, Mariette J.V., den Hollander, Nicolette S., van Ierland, Yvette, Koopmans, Marije, Kriek, Marjolein, Moghadasi, Setareh, Nibbeling, Esther A.R., Peeters-Scholte, Cacha M.P.C.D., Potjer, Thomas P., van Rij, Maartje, Ruivenkamp, Claudia A.L., Rutten, Julie W., Steggerda, Sylke J., Suerink, Manon, Tan, Ratna N.G.B., van der Tuin, Karin, Visser, Remco, van der Werf–t Lam, Anne Sophie, Williams, Monique, Witlox, Ruben, Santen, Gijs W.E., Genetica Klinische Genetica, Cancer, van der Sluijs, Pleuntje J., Aten, Emmelien, Barge-Schaapveld, Daniela Q.C.M., Bijlsma, Emilia K., Bökenkamp-Gramann, Regina, Kaat, Laura Donker, van Doorn, Remco, van de Putte, Dietje Fransen, van Haeringen, Arie, ten Harkel, Arend D.J., Hilhorst-Hofstee, Yvonne, Hoffer, Mariette J.V., den Hollander, Nicolette S., van Ierland, Yvette, Koopmans, Marije, Kriek, Marjolein, Moghadasi, Setareh, Nibbeling, Esther A.R., Peeters-Scholte, Cacha M.P.C.D., Potjer, Thomas P., van Rij, Maartje, Ruivenkamp, Claudia A.L., Rutten, Julie W., Steggerda, Sylke J., Suerink, Manon, Tan, Ratna N.G.B., van der Tuin, Karin, Visser, Remco, van der Werf–t Lam, Anne Sophie, Williams, Monique, Witlox, Ruben, and Santen, Gijs W.E.

Published
2019

82. Biallelic loss of LDB3leads to a lethal pediatric dilated cardiomyopathy

Author

Koopmann, Tamara T., Jamshidi, Yalda, Naghibi-Sistani, Mohammad, van der Klift, Heleen M., Birjandi, Hassan, Al-Hassnan, Zuhair, Alwadai, Abdullah, Zifarelli, Giovanni, Karimiani, Ehsan G., Sedighzadeh, Sahar, Bahreini, Amir, Nouri, Nayereh, Peter, Merlene, Watanabe, Kyoko, van Duyvenvoorde, Hermine A., Ruivenkamp, Claudia A. L., Teunissen, Aalbertine K. K., Ten Harkel, Arend D. J., van Duinen, Sjoerd G., Haak, Monique C., Prada, Carlos E., Santen, Gijs W. E., and Maroofian, Reza

Abstract

Autosomal dominant variants in LDB3(also known as ZASP), encoding the PDZ-LIM domain-binding factor, have been linked to a late onset phenotype of cardiomyopathy and myofibrillar myopathy in humans. However, despite knockout mice displaying a much more severe phenotype with premature death, bi-allelic variants in LDB3have not yet been reported. Here we identify biallelic loss-of-function variants in five unrelated cardiomyopathy families by next-generation sequencing. In the first family, we identified compound heterozygous LOF variants in LDB3in a fetus with bilateral talipes and mild left cardiac ventricular enlargement. Ultra-structural examination revealed highly irregular Z-disc formation, and RNA analysis demonstrated little/no expression of LDB3 protein with a functional C-terminal LIM domain in muscle tissue from the affected fetus. In a second family, a homozygous LDB3nonsense variant was identified in a young girl with severe early-onset dilated cardiomyopathy with left ventricular non-compaction; the same homozygous nonsense variant was identified in a third unrelated female infant with dilated cardiomyopathy. We further identified homozygous LDB3frameshift variants in two unrelated probands diagnosed with cardiomegaly and severely reduced left ventricular ejection fraction. Our findings demonstrate that recessive LDB3variants can lead to an early-onset severe human phenotype of cardiomyopathy and myopathy, reminiscent of the knockout mouse phenotype, and supporting a loss of function mechanism.

Published
2022
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83. Emotional and behavioral problems in children with dilated cardiomyopathy.

Author

van der Mheen, Malindi, van der Meulen, Marijke H, den Boer, Susanna L, Schreutelkamp, Dayenne J, van der Ende, Jan, de Nijs, Pieter FA, Breur, Johannes MPJ, Tanke, Ronald B, Blom, Nico A, Rammeloo, Lukas AJ, ten Harkel, Arend DJ, du Marchie Sarvaas, Gideon J, Utens, Elisabeth MWJ, and Dalinghaus, Michiel

Subjects
AFFECTIVE disorders, AGE distribution, ANXIETY, BEHAVIOR disorders in children, CHILD Behavior Checklist, COMPARATIVE studies, MENTAL depression, LONGITUDINAL method, MEDICAL cooperation, CLASSIFICATION of mental disorders, SCIENTIFIC observation, PSYCHOMETRICS, QUESTIONNAIRES, REFERENCE values, RESEARCH, RESEARCH funding, SEX distribution, ATTITUDES toward death, SOCIAL support, PARENT attitudes, CROSS-sectional method, PROPORTIONAL hazards models, DATA analysis software, DILATED cardiomyopathy, DESCRIPTIVE statistics, CHILDREN
Abstract

Background: Dilated cardiomyopathy (DCM) in children is an important cause of severe heart failure and carries a poor prognosis. Adults with heart failure are at increased risk of anxiety and depression and such symptoms predict adverse clinical outcomes such as mortality. In children with DCM, studies examining these associations are scarce. Aims: We studied whether in children with DCM: (1) the level of emotional and behavioral problems was increased as compared to normative data, and (2) depressive and anxiety problems were associated with the combined risk of death or cardiac transplantation. Methods: To assess emotional and behavioral problems in children with DCM, parents of 68 children, aged 1.5–18 years (6.9±5.7 years), completed the Child Behavior Checklist. Results: Compared to normative data, more young children (1.5–5 years) with DCM had somatic complaints (24.3% vs. 8.0%; p <.001), but fewer had externalizing problems (5.4% vs. 17.0%; p =.049). Overall internalizing problems did not reach significance. Compared to normative data, more older children (6–18 years) showed internalizing problems (38.7% vs. 17.0%; p =.001), including depressive (29.0% vs. 8.0%; p <.001) and anxiety problems (19.4% vs. 8.0%; p =.023), and somatic complaints (29.0% vs. 8.0%; p <.001). Anxiety and depressive problems, corrected for heart failure severity, did not predict the risk of death or cardiac transplantation. Conclusion: Children of 6 years and older showed more depressive and anxiety problems than the normative population. Moreover, in both age groups, somatic problems were common. No association with outcome could be demonstrated. [ABSTRACT FROM AUTHOR]

Published
2020
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87. Long-term follow-up after ventricular septal defect repair in children: Cardiac autonomic control, cardiac function and exercise capacity

Author

Nederend, Ineke, de Geus, Eco J.C., Blom, Nico A., ten Harkel, Arend D.J., Nederend, Ineke, de Geus, Eco J.C., Blom, Nico A., and ten Harkel, Arend D.J.

Abstract

OBJECTIVES: Survival after surgical repair of a ventricular septal defect (VSD) is good, but, as in almost all congenital heart diseases, late complications are frequent in adulthood. The exact mechanisms, timing and who is at risk are not fully understood. Altered cardiac autonomic nervous system (ANS) activity might play a role in these long-term sequelae. The aim of this study was to extensively evaluate children late after VSD repair including their cardiac ANS activity, cardiac function and exercise capacity.METHODS: Thirty-three patients after surgical VSD repair and 66 healthy age-matched controls underwent 24-h monitoring of ANS control and cardiac output using impedance cardiography, detailed echocardiography and cardiopulmonary exercise testing.RESULTS: Ambulatory cardiac ANS control was not different between the patients and the controls. Right ventricular function, exercise capacity and ambulatory cardiac output were decreased in patients compared with the controls. No relationships were found between cardiac ANS activity and cardiac function.CONCLUSIONS: Long (average time after repair was 9.9 years) after successful surgical correction of a VSD, cardiac ANS control is not different from the controls. Right ventricular function and exercise capacity are impaired in VSD patients. Post-surgical outcome in these patients may be less benign than presently assumed; therefore, follow-up should be continued into adulthood to detect adverse outcomes in a timely fashion.

Published
2018
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89. Distribution of strain patterns in children with dilated cardiomyopathy

Author

den Boer, Susanna L., primary, du Marchie Sarvaas, Gideon J., additional, Klitsie, Liselotte M., additional, van Iperen, Gabriëlle G., additional, Tanke, Ronald B., additional, Helbing, Willem A., additional, Backx, Ad P.C.M., additional, Rammeloo, Lukas A.J., additional, Dalinghaus, Michiel, additional, and ten Harkel, Arend D.J., additional

Published
2017
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90. Parent reports of health-related quality of life and heart failure severity score independently predict outcome in children with dilated cardiomyopathy

Author

den Boer, Susanna L., primary, Baart, Sara J., additional, van der Meulen, Marijke H., additional, van Iperen, Gabriëlle G., additional, Backx, Ad P., additional, ten Harkel, Arend D., additional, Rammeloo, Lukas A., additional, du Marchie Sarvaas, Gideon J., additional, Tanke, Ronald B., additional, Helbing, Willem A., additional, Utens, Elisabeth M., additional, and Dalinghaus, Michiel, additional

Published
2017
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91. Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure

Author

den Boer, Susanna L, Flipse, Daniël H K, van der Meulen, Marijke H, Backx, Ad P C M, du Marchie Sarvaas, Gideon J, Ten Harkel, Arend D J, van Iperen-Schutte, Gabrielle, Rammeloo, Lukas A J, Tanke, Ronald B, Helbing, Willem A, Takken, Tim, Dalinghaus, Michiel, den Boer, Susanna L, Flipse, Daniël H K, van der Meulen, Marijke H, Backx, Ad P C M, du Marchie Sarvaas, Gideon J, Ten Harkel, Arend D J, van Iperen-Schutte, Gabrielle, Rammeloo, Lukas A J, Tanke, Ronald B, Helbing, Willem A, Takken, Tim, and Dalinghaus, Michiel

Published
2017

92. Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure

Author

Cardiologie patientenzorg, Other research (not in main researchprogram), Kinderbewegingszorg patientenzorg, Child Health, den Boer, Susanna L, Flipse, Daniël H K, van der Meulen, Marijke H, Backx, Ad P C M, du Marchie Sarvaas, Gideon J, Ten Harkel, Arend D J, van Iperen-Schutte, Gabrielle, Rammeloo, Lukas A J, Tanke, Ronald B, Helbing, Willem A, Takken, Tim, Dalinghaus, Michiel, Cardiologie patientenzorg, Other research (not in main researchprogram), Kinderbewegingszorg patientenzorg, Child Health, den Boer, Susanna L, Flipse, Daniël H K, van der Meulen, Marijke H, Backx, Ad P C M, du Marchie Sarvaas, Gideon J, Ten Harkel, Arend D J, van Iperen-Schutte, Gabrielle, Rammeloo, Lukas A J, Tanke, Ronald B, Helbing, Willem A, Takken, Tim, and Dalinghaus, Michiel

Published
2017

93. Does functional health status predict health-related quality of life in children after Fontan operation?

Author

Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, Helbing, Willem A., Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, and Helbing, Willem A.

Published
2016

94. Response profiles of oxygen uptake efficiency during exercise in healthy children

Author

Bongers, Bart C., Bongers, Bart C., Hulzebos, Erik H. J., Helbing, Willem A., ten Harkel, Arend D. J., van Brussel, Marco, Takken, Tim, Bongers, Bart C., Bongers, Bart C., Hulzebos, Erik H. J., Helbing, Willem A., ten Harkel, Arend D. J., van Brussel, Marco, and Takken, Tim

Abstract

Background: Oxygen uptake efficiency (OUE), the relation between oxygen uptake (VO2) and minute ventilation (VE), differs between healthy children and children with heart disease. This study aimed to investigate the normal response profiles of OUE during a progressive cardiopulmonary exercise test. Design: Cross-sectional. Methods: Healthy children between eight and 19 years of age (114 boys and 100 girls, mean +/- SD age 12.7 +/- 2.8 years) performed a maximal cardiopulmonary exercise test. Peak VO2 (VO2peak), ventilatory threshold and peak VE were determined. OUE was determined by the OUE plateau (OUEP), OUE at the ventilatory threshold (OUE@VT) and OUE slope (OUES). Results: OUEP (42.4 +/- 4.6) and OUE@VT (41.9 +/- 4.7) were similar and less variable than OUES (2138 +/- 703). OUEP correlated strongly with OUE@VT (r=0.974); however, OUEP was weak-to-moderately correlated with VO2peak (r=0.646), the ventilatory threshold (r=0.548) and OUES (r=0.589). OUES correlated strongly with VO2peak (r=0.948) and the ventilatory threshold (r=0.856). Reference centiles for OUEP show an almost linear increase from about 37 in eight-year olds to about 47 in 18-year olds, with no sex-difference. OUES increased from about 1400 in eight-year-old boys to approximately 3500 in 18-year-old boys. OUES increased from roughly 1250 in eight-year-old girls to about 2650 in 18-year-old girls. Conclusions: This study provides sex- and age-related normative values for both OUEP and OUES, which facilitates the interpretation of OUE in children. OUEP and OUES are objective and non-invasive cardiopulmonary exercise test parameters which do not require a maximal effort and might be indicative of cardiorespiratory function during exercise.

Published
2016

95. Does functional health status predict health-related quality of life in children after Fontan operation?

Author

Cardiologie patientenzorg, Other research (not in main researchprogram), Kinderbewegingszorg patientenzorg, Child Health, Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, Helbing, Willem A., Cardiologie patientenzorg, Other research (not in main researchprogram), Kinderbewegingszorg patientenzorg, Child Health, Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, and Helbing, Willem A.

Published
2016

96. Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure

Author

den Boer, Susanna L., primary, Flipse, Daniël H. K., additional, van der Meulen, Marijke H., additional, Backx, Ad P. C. M., additional, du Marchie Sarvaas, Gideon J., additional, Ten Harkel, Arend D. J., additional, van Iperen, Gabriëlle G., additional, Rammeloo, Lukas A. J., additional, Tanke, Ronald B., additional, Helbing, Willem A., additional, Takken, Tim, additional, and Dalinghaus, Michiel, additional

Published
2016
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100. Reply to the editor

Author

Klitsie, Liselotte M., Roest, Arno A.W., Blom, Nico A., and Ten Harkel, Arend D.J.

Subjects
Pulmonary and Respiratory Medicine, Male, Transposition of Great Vessels, Ventricular Function, Right, Humans, Surgery, Female, Cardiac Surgical Procedures, Cardiology and Cardiovascular Medicine, Ventricular Function, Left
Published
2013

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