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51. Health Care Professionals’ Interest in Vaccination Training in Switzerland: A Quantitative Survey

Author

Lucas Ramanathan, Pia, primary, Baldesberger, Nadja, additional, Dietrich, Léna G., additional, Speranza, Camilla, additional, Lüthy, Alyssa, additional, Buhl, Andrea, additional, Gisin, Martina, additional, Koch, Roswitha, additional, Nicca, Dunja, additional, Suggs, L. Suzanne, additional, Huber, Benedikt M., additional, Deml, Michael J., additional, and Tarr, Philip E., additional

Published
2022
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52. Sexuell übertragbare Infektionen: Kommunikation, Urethritis, Genitalwarzen

Author

Hunziker, Milena, primary, Schoepf, Isabella C., additional, Surber, Jonathan, additional, Bertisch, Barbara, additional, Hampel, Benjamin, additional, Meynard, Anne, additional, Brenner Cortazar, Maja, additional, Kulier, Regina, additional, Egli, Rolf, additional, Grandinetti, Tanja, additional, Etter, Gisela, additional, Dietrich, Lna G., additional, Haerry, David, additional, Capol, Svend, additional, Aebi Popp, Karoline, additional, Mller, Simon, additional, Schmidt, Axel J., additional, and Tarr, Philip, additional

Published
2022
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53. Maladies sexuellement transmissibles: Communication, urétrite, verrues génitales

Author

Hunziker, Milena, primary, Schoepf, Isabella C., additional, Surber, Jonathan, additional, Bertisch, Barbara, additional, Hampel, Benjamin, additional, Meynard, Anne, additional, Brenner Cortazar, Maja, additional, Kulier, Regina, additional, Egli, Rolf, additional, Grandinetti, Tanja, additional, Etter, Gisela, additional, Dietrich, Lna G., additional, Haerry, David, additional, Capol, Svend, additional, Aebi Popp, Karoline, additional, Mller, Simon, additional, Schmidt, Axel J., additional, and Tarr, Philip, additional

Published
2022
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54. Maladies sexuellement transmissibles: épidémiologie et prise en charge

Author

Tarr, Philip E., primary, Schoepf, Isabella C., additional, Hunziker, Milena, additional, Surber, Jonathan, additional, Bertisch, Barbara, additional, Hampel, Benjamin, additional, Meynard, Anne, additional, Brenner Cortazar, Maja, additional, Kulier, Regina, additional, Egli, Rolf, additional, Grandinetti, Tanja, additional, Etter, Gisela, additional, Dietrich, Lena G., additional, Haerry, David, additional, Capol, Svend, additional, Aebi Popp, Karoline, additional, Mller, Simon, additional, and Schmidt, Axel J., additional

Published
2022
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55. Affenpocken

Author

Simon, Noemi R., primary, Schpf, Isabella C., additional, Haerry, David, additional, Deml, Michael J., additional, Mller, Simon, additional, Aebi-Popp, Karoline, additional, Egli, Rolf, additional, Kulier, Regina, additional, Meynard, Anne, additional, Schmidt, Axel J., additional, Rowedder, Axel, additional, Bguelin, Charles, additional, Falch, Beatrix, additional, Etter, Gisela, additional, Bertisch, Barbara, additional, Braun, Dominique L., additional, Nemeth, Johannes, additional, Calmy, Alexandra, additional, and Tarr, Philip, additional

Published
2022
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56. La variole du singe

Author

Simon, Noemi R., primary, Schpf, Isabella C., additional, Haerry, David, additional, Deml, Michael J., additional, Mller, Simon, additional, Aebi-Popp, Karoline, additional, Egli, Rolf, additional, Kulier, Regina, additional, Meynard, Anne, additional, Schmidt, Axel J., additional, Rowedder, Axel, additional, Bguelin, Charles, additional, Falch, Beatrix, additional, Etter, Gisela, additional, Bertisch, Barbara, additional, Braun, Dominique L., additional, Nemeth, Johannes, additional, Calmy, Alexandra, additional, and Tarr, Philip, additional

Published
2022
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57. Sexuell übertragbare Infektionen: Epidemiologie und Management

Author

Tarr, Philip E., primary, Schoepf, Isabella C., additional, Hunziker, Milena, additional, Surber, Jonathan, additional, Bertisch, Barbara, additional, Hampel, Benjamin, additional, Meynard, Anne, additional, Brenner Cortazar, Maja, additional, Kulier, Regina, additional, Egli, Rolf, additional, Grandinetti, Tanja, additional, Etter, Gisela, additional, Dietrich, Lena G., additional, Haerry, David, additional, Capol, Svend, additional, Aebi Popp, Karoline, additional, Mller, Simon, additional, and Schmidt, Axel J., additional

Published
2022
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61. Distinguishing Clinical and Research Risks in Pragmatic Clinical Trials: The Need for Further Stakeholder Engagement.

Author

Wilfond, Benjamin S., Toraman Turk, Sinem, Kraft, Stephanie A., Weiss, Elliott M., Tarr, Philip I., Schnadower, David, and Freedman, Stephen B.

Subjects
HYDRATION, CONSENSUS (Social sciences), CLINICAL trials, FLUID therapy, HUMAN research subjects, STAKEHOLDER analysis, SCHOLARSHIPS, RISK assessment, RESEARCH ethics, INFORMED consent (Medical law), BIOETHICS
Abstract

The authors consider the case of a pragmatic clinical trial that raises important questions between informed consent and the risks associated with complex interventions and high stakes outcomes. Topics discussed include an approach to the ethical questions that arose in this trial and the need for more empirical research to guide the approach to future pragmatic trials.

Published
2023
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62. Folie à deux – Thrombose und Infektionen.

Author

Picker, Julia, Schwenke, Johannes, Neuenschwander, Lorenz, Nisslé, Sonja, Maurer, Christian, Egli, Rolf, Périard, Daniel, Staub, Daniel, Tsakiris, Dimitrios A., Aujesky, Drahomir, and Tarr, Philip

Subjects
ACUTE coronary syndrome, THROMBOEMBOLISM, THROMBOSIS, ATRIAL fibrillation, COVID-19, INFECTION, TUMORS, HEART failure
Abstract

Copyright of Praxis (16618157) is the property of Aerzteverlag medinfo AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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63. Determinants of HIV-1 broadly neutralizing antibody induction

Author

Rusert, Peter, Kouyos, Roger D, Kadelka, Claus, Ebner, Hanna, Schanz, Merle, Huber, Michael, Braun, Dominique L, Hozé, Nathanael, Scherrer, Alexandra, Magnus, Carsten, Weber, Jacqueline, Uhr, Therese, Cippa, Valentina, Thorball, Christian W, Kuster, Herbert, Cavassini, Matthias, Bernasconi, Enos, Hoffmann, Matthias, Calmy, Alexandra, Battegay, Manuel, Rauch, Andri, Yerly, Sabine, Aubert, Vincent, Klimkait, Thomas, Böni, Jürg, Fellay, Jacques, Regoes, Roland R, Günthard, Huldrych F, Trkola, Alexandra, Bucher, Heiner C, Ciuffi, Angela, Dollenmaier, Günther, Egger, Matthias, Elzi, Luigia, Fehr, Jan, Furrer, Hansjakob, Fux, Christoph A, Haerry, David, Hasse, Barbara, Hirsch, Hans H, Hösli, Irene, Kahlert, Christian, Kaiser, Laurent, Keiser, Olivia, Kovari, Helen, Ledergerber, Bruno, Martinetti, Gladys, de Tejada, Begoña Martinez, Marzolini, Catia, Metzner, Karin J, Müller, Nicolas, Nicca, Dunja, Pantaleo, Giuseppe, Paioni, Paolo, Rudin, Christoph, Schmid, Patrick, Speck, Roberto, Stöckle, Marcel, Tarr, Philip, Vernazza, Pietro, Wandeler, Gilles, and Weber, Rainer

Subjects
Host-virus relationships, HIV infections -- Development and progression -- Care and treatment, Antibodies -- Observations, Immune response -- Observations, Biological sciences, Health
Abstract

Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet basic aspects of their induction remain poorly understood. Here we report on viral, host and disease factors that steer bnAb evolution using the results of a systematic survey in 4,484 HIV-1-infected individuals that identified 239 bnAb inducers. We show that three parameters that reflect the exposure to antigen--viral load, length of untreated infection and viral diversity--independently drive bnAb evolution. Notably, black participants showed significantly (P = 0.0086-0.038) higher rates of bnAb induction than white participants. Neutralization fingerprint analysis, which was used to delineate plasma specificity, identified strong virus subtype dependencies, with higher frequencies of CD4-binding-site bnAbs in infection with subtype B viruses (P = 0.02) and higher frequencies of V2-glycan-specific bnAbs in infection with non-subtype B viruses (P = 1 x 10[sup.-5]). Thus, key host, disease and viral determinants, including subtype-specific envelope features that determine bnAb specificity, remain to be unraveled and harnessed for bnAb-based vaccine design., Author(s): Peter Rusert [1]; Roger D Kouyos [1, 2]; Claus Kadelka [1, 2]; Hanna Ebner [1]; Merle Schanz [1]; Michael Huber [1]; Dominique L Braun [1, 2]; Nathanael Hozé [3]; [...]

Published
2016
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64. Factors Associated With Liver Steatosis in People With Human Immunodeficiency Virus on Contemporary Antiretroviral Therapy

Author

Riebensahm, Carlotta, Berzigotti, Annalisa, Surial, Bernard, Günthard, Huldrych F, Tarr, Philip E, Furrer, Hansjakob, Rauch, Andri, and Wandeler, Gilles

Subjects
Infectious Diseases, Oncology, 360 Social problems & social services, 610 Medicine & health
Abstract

Background Given the impact of new antiretroviral drugs on weight and metabolic parameters, their potential contribution to the development of liver steatosis is of concern. We investigated the determinants of liver steatosis in patients on antiretroviral therapy (ART) in the Swiss HIV Cohort Study (SHCS). Methods Between 2019 and 2021, we measured liver stiffness and controlled attenuation parameter (CAP) using transient elastography in consecutive SHCS participants at Bern University Hospital. Individuals with viral hepatitis coinfection and pregnant women were excluded. We used multivariable logistic regression to explore factors associated with steatosis. Results Of 416 participants, 113 (27.2%) were female, median age was 51 years (interquartile range [IQR], 43–59), 305 (73.3%) were of European origin, and 212 (51.0%) were overweight/obese (body mass index [BMI] ≥25 kg/m2). Liver steatosis (CAP ≥248 dB/m) was present in 212 (51.0%) participants, 11 (5.2%) of whom had significant fibrosis or cirrhosis. One hundred seventy-nine (43.0%) met the criteria for metabolic-associated fatty liver disease (MAFLD). Among 64 individuals with a BMI Conclusions Our findings suggest a high prevalence of liver steatosis among people with HIV (PWH) on ART in Switzerland. In addition to established risk factors, the use of tenofovir alafenamide was associated with hepatic steatosis.

Published
2022

65. Impact of Latent Tuberculosis Infection on the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study

Author

Tepekule, Burcu, Kusejko, Katharina, Zeeb, Marius, Tarr, Philip E, Calmy, Alexandra, Battegay, Manuel, Furrer, Hansjakob, Cavassini, Matthias, Bernasconi, Enos, Notter, Julia, G��nthard, Huldrych F, Nemeth, Johannes, and Kouyos, Roger D

Subjects
610 Medicine & health, bacterial infections and mycoses
Abstract

While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV (PHIV) in the Swiss HIV Cohort Study via time-dependent cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR=1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.

Published
2022

66. Impact of Latent Tuberculosis on Diabetes

Author

Tepekule, Burcu, Kusejko, Katharina, Zeeb, Marius, Tarr, Philip E, Calmy, Alexandra, Battegay, Manuel, Furrer, Hansjakob, Cavassini, Matthias, Bernasconi, Enos, Notter, Julia, Günthard, Huldrych F, Nemeth, Johannes, Kouyos, Roger D, University of Zurich, and Tepekule, Burcu

Subjects
10028 Institute of Medical Virology, 10234 Clinic for Infectious Diseases, 2723 Immunology and Allergy, 610 Medicine & health, 2725 Infectious Diseases
Published
2022

68. Zeckenprävention

Author

Tarr, Philip, primary, Lanz, Ccile, additional, Nemeth, Johannes, additional, Knzli, Esther, additional, Dapprich, Michael, additional, Etter, Gisela, additional, Meynard, Anne, additional, Bguelin, Charles, additional, Schmidt, Axel J., additional, and Boggian, Katia, additional

Published
2022
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69. Prévention des piqûres de tiques

Author

Tarr, Philip, primary, Lanz, Ccile, additional, Nemeth, Johannes, additional, Knzli, Esther, additional, Dapprich, Michael, additional, Etter, Gisela, additional, Meynard, Anne, additional, Bguelin, Charles, additional, Schmidt, Axel J., additional, and Boggian, Katia, additional

Published
2022
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71. Frühsommer-Meningoenzephalitis (FSME) und FSME Impfung

Author

Lanz, Ccile, primary, Bguelin, Charles, additional, Knzli, Esther, additional, Schmid Thurneysen, Lisa, additional, Wingeier, Bernhard, additional, Hug, Salome, additional, Hug-Batschelet, Henriette, additional, Dapprich, Michael, additional, Nemeth, Johannes, additional, Etter, Gisela, additional, Meynard, Anne, additional, Schmidt, Axel, additional, Boggian, Katia, additional, and Tarr, Philip, additional

Published
2022
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72. Méningo-encéphalite à tiques (FSME) et vaccination contre la FSME

Author

Lanz, Ccile, primary, Bguelin, Charles, additional, Knzli, Esther, additional, Schmid Thurneysen, Lisa, additional, Wingeier, Bernhard, additional, Hug, Salome, additional, Hug-Batschelet, Henriette, additional, Dapprich, Michael, additional, Nemeth, Johannes, additional, Etter, Gisela, additional, Meynard, Anne, additional, Schmidt, Axel, additional, Boggian, Katia, additional, and Tarr, Philip, additional

Published
2022
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73. Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Author

MAGNIFICENT Consortium, INSIGHT, Swiss HIV Cohort Study, Rotger, Margalida, Glass, Tracy R., Junier, Thomas, Lundgren, Jens, Neaton, James D., Poloni, Estella S., van 't Wout, Angélique B., Lubomirov, Rubin, Colombo, Sara, Martinez, Raquel, Rauch, Andri, Günthard, Huldrych F., Neuhaus, Jacqueline, Wentworth, Deborah, van Manen, Danielle, Gras, Luuk A., Schuitemaker, Hanneke, Albini, Laura, Torti, Carlo, Jacobson, Lisa P., Li, Xiuhong, Kingsley, Lawrence A., Carli, Federica, Guaraldi, Giovanni, Ford, Emily S., Sereti, Irini, Hadigan, Colleen, Martinez, Esteban, Arnedo, Mireia, Egaña-Gorroño, Lander, Gatell, Jose M., Law, Matthew, Bendall, Courtney, Petoumenos, Kathy, Rockstroh, Jürgen, Wasmuth, Jan-Christian, Kabamba, Kabeya, Delforge, Marc, De Wit, Stephane, Berger, Florian, Mauss, Stefan, de Paz Sierra, Mariana, Losso, Marcelo, Belloso, Waldo H., Leyes, Maria, Campins, Antoni, Mondi, Annalisa, De Luca, Andrea, Bernardino, Ignacio, Barriuso-Iglesias, Mónica, Torrecilla-Rodriguez, Ana, Gonzalez-Garcia, Juan, Arribas, José R., Fanti, Iuri, Gel, Silvia, Puig, Jordi, Negredo, Eugenia, Gutierrez, Mar, Domingo, Pere, Fischer, Julia, Fätkenheuer, Gerd, Alonso-Villaverde, Carlos, Macken, Alan, Woo, James, McGinty, Tara, Mallon, Patrick, Mangili, Alexandra, Skinner, Sally, Wanke, Christine A., Reiss, Peter, Weber, Rainer, Bucher, Heiner C., Fellay, Jacques, Telenti, Amalio, and Tarr, Philip E.

Published
2013
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74. Telomere Length Declines In Persons Living With HIV Before Antiretroviral Therapy Start But Not After Viral Suppression: A Longitudinal Study Over >17 Years

Author

Schoepf, Isabella C, Thorball, Christian W, Ledergerber, Bruno, Kootstra, Neeltje A, Reiss, Peter, Raffenberg, Marieke, Engel, Tanja, Braun, Dominique L, Hasse, Barbara, Thurnheer, Christine, Marzolini, Catia, Seneghini, Marco, Bernasconi, Enos, Cavassini, Matthias, Buvelot, Hélène, Arribas, José R, Kouyos, Roger D, Fellay, Jacques, Günthard, Huldrych F, Tarr, Philip E, Swiss HIV Cohort Study, and University of Zurich

Subjects
10028 Institute of Medical Virology, 10234 Clinic for Infectious Diseases, 570 Life sciences, biology, 610 Medicine & health
Published
2022

75. Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS)

Author

Hachfeld, Anna; https://orcid.org/0000-0001-9308-7130, Atkinson, Andrew, Stute, Petra, Calmy, Alexandra, Tarr, Philip E, Darling, Katharine; https://orcid.org/0000-0003-1449-3873, Babouee Flury, Baharak, Polli, Christian, Sultan-Beyer, Leila, Abela, Irene A, Aebi-Popp, Karoline; https://orcid.org/0000-0002-9337-900X, Hachfeld, Anna; https://orcid.org/0000-0001-9308-7130, Atkinson, Andrew, Stute, Petra, Calmy, Alexandra, Tarr, Philip E, Darling, Katharine; https://orcid.org/0000-0003-1449-3873, Babouee Flury, Baharak, Polli, Christian, Sultan-Beyer, Leila, Abela, Irene A, and Aebi-Popp, Karoline; https://orcid.org/0000-0002-9337-900X

Abstract

OBJECTIVES We aimed to assess prevalence and age at menopause, identify factors associated with early menopause and explore the provision and utilization of healthcare in women living with HIV in Switzerland. METHODS This was a retrospective Swiss HIV Cohort Study analysis from January 2010 to December 2018. Descriptive statistics to characterise the population and menopause onset. Logistic regression analysis to identify risk factors for early menopause. RESULTS Of all women in the SHCS, the proportion of postmenopausal women tripled from 11.5% (n = 274) in 2010 to 36.1% (n = 961) in 2018. The median age at menopause was 50 years. Early menopause (< 45 years) occurred in 115 (10.2%) women and premature ovarian insufficiency (POI) (< 40 years) in 23 (2%) women. Early menopause was associated with black ethnicity (52.2% vs. 21.6%, p < 0.001), but not with HIV acquisition mode, CDC stage, viral suppression, CD4 cell count, hepatitis C, smoking or active drug use. While 92% of the postmenopausal women underwent a gynaecological examination during the 36 months before menopause documentation, only 27% received a bone mineral density measurement within 36 months after the last bleed and 11% were on hormone replacement therapy at the time of menopause documentation. CONCLUSIONS The median age of women living with HIV at menopause is around 2 years lower than that reported for HIV-negative women in Switzerland. HIV care providers need to adapt their services to the requirements of the increasing number of women living with HIV transitioning through menopause. They should be able to recognize menopause-associated symptoms and improve access to bone mineral density measurement as well as hormone replacement therapy.

Published
2022

76. Author Correction: Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV

Author

Bick, Alexander G, Popadin, Konstantin, Thorball, Christian W, Uddin, Md Mesbah, Zanni, Markella V, Yu, Bing, Cavassini, Matthias, Rauch, Andri, Tarr, Philip, Schmid, Patrick, Bernasconi, Enos, Günthard, Huldrych F, et al, Bick, Alexander G, Popadin, Konstantin, Thorball, Christian W, Uddin, Md Mesbah, Zanni, Markella V, Yu, Bing, Cavassini, Matthias, Rauch, Andri, Tarr, Philip, Schmid, Patrick, Bernasconi, Enos, Günthard, Huldrych F, and et al

Published
2022

77. Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV

Author

Bick, Alexander G, Popadin, Konstantin, Thorball, Christian W, Uddin, Md Mesbah, Zanni, Markella V, Yu, Bing, Cavassini, Matthias, Rauch, Andri, Tarr, Philip, Schmid, Patrick, Bernasconi, Enos, Günthard, Huldrych F, et al, Bick, Alexander G, Popadin, Konstantin, Thorball, Christian W, Uddin, Md Mesbah, Zanni, Markella V, Yu, Bing, Cavassini, Matthias, Rauch, Andri, Tarr, Philip, Schmid, Patrick, Bernasconi, Enos, Günthard, Huldrych F, and et al

Abstract

People living with human immunodeficiency virus (PLWH) have significantly increased risk for cardiovascular disease in part due to inflammation and immune dysregulation. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition and expansion of hematopoietic stem cells due to leukemogenic driver mutations, increases risk for both hematologic malignancy and coronary artery disease (CAD). Since increased inflammation is hypothesized to be both a cause and consequence of CHIP, we hypothesized that PLWH have a greater prevalence of CHIP. We searched for CHIP in multi-ethnic cases from the Swiss HIV Cohort Study (SHCS, n = 600) and controls from the Atherosclerosis Risk in the Communities study (ARIC, n = 8111) from blood DNA-derived exome sequences. We observed that HIV is associated with a twofold increase in CHIP prevalence, both in the whole study population and in a subset of 230 cases and 1002 matched controls selected by propensity matching to control for demographic imbalances (SHCS 7%, ARIC 3%, p = 0.005). We also observed that ASXL1 is the most commonly mutated CHIP-associated gene in PLWH. Our results suggest that CHIP may contribute to the excess cardiovascular risk observed in PLWH.

Published
2022

79. La borréliose: Épidémiologie, érythème migrant

Author

Tarr, Philip, primary, Lanz, Ccile, additional, Nemeth, Johannes, additional, Knzli, Esther, additional, Dapprich, Michael, additional, Etter, Gisela, additional, Meynard, Anne, additional, Bguelin, Charles, additional, Schmid, Axel J., additional, and Boggian, Katia, additional

Published
2022
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80. La borréliose: Arthrite, cardite, neuroborréliose

Author

Tarr, Philip, primary, Lanz, Ccile, additional, Nemeth, Johannes, additional, Knzli, Esther, additional, Dapprich, Michael, additional, Ettere, Gisela, additional, Anne, Meynar, additional, Bguelin, Charles, additional, Schmid, Axel J., additional, and Katia, Boggian, additional

Published
2022
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81. Borreliose: Epidemiologie, Erythema migrans

Author

Tarr, Philip, primary, Lanz, Ccile, additional, Nemeth, Johannes, additional, Knzli, Esther, additional, Dapprich, Michael, additional, Etter, Gisela, additional, Meynard, Anne, additional, Bguelin, Charles, additional, Schmid, Axel J., additional, and Boggian, Katia, additional

Published
2022
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82. Borreliose: Arthritis, Karditis, Neuroborreliose

Author

Tarr, Philip, primary, Lanz, Ccile, additional, Nemeth, Johannes, additional, Knzli, Esther, additional, Dapprich, Michael, additional, Ettere, Gisela, additional, Anne, Meynar, additional, Bguelin, Charles, additional, Schmid, Axel J., additional, and Katia, Boggian, additional

Published
2022
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83. Vaccine hesitancy and HPV vaccine uptake among male and female youth in Switzerland: a cross-sectional study

Author

Kiener, Laura M, primary, Schwendener, Corina L, additional, Jafflin, Kristen, additional, Meier, Audrey, additional, Reber, Noah, additional, Schärli Maurer, Susanna, additional, Muggli, Franco, additional, Gültekin, Nejla, additional, Huber, Benedikt M, additional, Merten, Sonja, additional, Deml, Michael J, additional, and Tarr, Philip E, additional

Published
2022
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84. Impfskepsis – 10 Punkte für eine erfolgreiche Impfberatung

Author

Schmid-Thurneysen, Lisa, primary, Zimmermann, Clara, additional, Deml, Michael J., additional, Wingeier, Bernhard, additional, Gallmann, Caesar, additional, Carp, Peter, additional, Iff, Martin, additional, Hug-Batschelet, Henriette, additional, Schmidt, Martin, additional, Avoledo, Pierino, additional, Etter, Gisela, additional, HUBER, Benedikt M., additional, and Tarr, Philip, additional

Published
2022
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85. Vaccino-hésitation: 10 messages pour une consultation vaccinale réussie

Author

Schmid-Thurneysen, Lisa, primary, Zimmermann, Clara, additional, Deml, Michael J., additional, Wingeier, Bernhard, additional, Gallmann, Caesar, additional, Carp, Peter, additional, Iff, Martin, additional, Hug-Batschelet, Henriette, additional, Schmidt, Martin, additional, Avoledo, Pierino, additional, Etter, Gisela, additional, HUBER, Benedikt M., additional, and Tarr, Philip, additional

Published
2022
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87. Cohort Profile Update: The Swiss HIV Cohort Study (SHCS)

Author

Scherrer, Alexandra U, Traytel, Anna, Braun, Dominique L, Calmy, Alexandra, Battegay, Manuel, Cavassini, Matthias, Furrer, Hansjakob, Schmid, Patrick, Bernasconi, Enos, Stoeckle, Marcel, Kahlert, Christian, Trkola, Alexandra, Kouyos, Roger D, Tarr, Philip, Marzolini, Catia, Wandeler, Gilles, Fellay, Jacques, Bucher, Heiner, Yerly, Sabine, Suter, Franziska, Hirsch, Hans, Huber, Michael, Dollenmaier, Günter, Perreau, Matthieu, Martinetti, Gladys, Rauch, Andri, Günthard, Huldrych F, Swiss HIV Cohort Study, and University of Zurich

Subjects
10028 Institute of Medical Virology, medicine.medical_specialty, Epidemiology, business.industry, Human immunodeficiency virus (HIV), HIV Infections, 610 Medicine & health, General Medicine, medicine.disease_cause, Cohort Studies, 10234 Clinic for Infectious Diseases, Internal medicine, Cohort, HIV-1, medicine, Humans, 610 Medizin und Gesundheit, business, Switzerland, 570 Biowissenschaften, Biologie, Cohort study
Published
2022

88. Maladies sexuellement transmissibles: épidémiologie et prise en charge

Author

Schoepf, Isabella, Hunziker, Milena, Surber, Jonathan, Bertisch, Barbara, Hampel, Benjamin, Meynard, Anne, Brenner Cortazar, Maja, Kulier, Regina, Egli, Rolf, Grandinetti, Tanja, Etter, Gisela, Dietrich, Lena G., Haerry, David, Capol, Svend, Aebi Popp, Karoline, Müller, Simon, Schmidt, Axel J., and Tarr, Philip

Subjects
610 Medicine & health, General Medicine
Published
2022

89. Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons Living with HIV: The Swiss HIV Cohort Study

Author

Schoepf, Isabella C, Thorball, Christian W, Kovari, Helen, Ledergerber, Bruno, Buechel, Ronny R, Calmy, Alexandra, Weber, Rainer, Kaufmann, Philipp A, Nkoulou, René, Schwenke, Johannes M, Braun, Dominique L, Fellay, Jacques, and Tarr, Philip E

Subjects
hiv infection, aging, multivariable analysis, association, heart, tomography, infection, atherosclerotic cardiovascular-disease, polygenic risk score, loci, angiography, subclinical coronary artery disease, intima-media thickness, 610 Medicine & health, events
Abstract

Background. In people living with human immunodeficiency virus (HIV) (PLWH), individual polygenic risk scores (PRSs) are associated with coronary artery disease (CAD) events. Whether PRSs are associated with subclinical CAD is unknown., Methods. In Swiss HIV Cohort Study participants of European descent, we defined subclinical CAD as presence of soft, mixed, or high-risk plaque (SMHRP) on coronary computed tomography (CT) angiography, or as participants in the top tertile of the study population's coronary artery calcium (CAC) score, using noncontrast CT. We obtained univariable and multivariable odds ratios (ORs) for subclinical CAD endpoints based on nongenetic risk factors, and validated genome-wide PRSs built from single nucleotide polymorphisms associated with CAD, carotid intima-media thickness (IMT), or longevity in the general population., Results. We included 345 genotyped participants (median age, 53 years; 89% male; 96% suppressed HIV RNA); 172 and 127 participants had SMHRP and CAC, respectively. CAD-associated PRS and IMT-associated PRS were associated with SMHRP and CAC (all P < .01), but longevity PRS was not. Participants with unfavorable CAD-PRS (top quintile) had an adjusted SMHRP OR = 2.58 (95% confidence interval [CI], 1.18-5.67), and a CAC OR = 3.95 (95% CI, 1.45-10.77) vs. bottom quintile. Unfavorable nongenetic risk (top vs. bottom quintile) was associated with adjusted SMHRP OR = 24.01 (95% CI, 9.75-59.11), and a CAC-OR = 65.07 (95% CI, 18.48-229.15). Area under the receiver operating characteristic curve increased when we added CAD-PRS to nongenetic risk factors (SMHRP: 0.75 and 0.78, respectively; CAC: 0.80 and 0.83, respectively)., Conclusions. In Swiss PLWH, subclinical CAD is independently associated with an individual CAD-associated PRS. Combining nongenetic and genetic cardiovascular risk factors provided the most powerful subclinical CAD prediction.

Published
2022
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90. Maladies sexuellement transmissibles: Communication, urétrite, verrues génitales

Author

Hunziker, Milena, Schoepf, Isabella C., Surber, Jonathan, Bertisch, Barbara, Hampel, Benjamin, Meynard, Anne, Brenner Cortazar, Maja, Kulier, Regina, Egli, Rolf, Grandinetti, Tanja, Etter, Gisela, Dietrich, Lena G., Haerry, David, Capol, Svend, Aebi Popp, Karoline, Mller, Simon, Schmidt, Axel J., and Tarr, Philip

Subjects
610 Medicine & health, General Medicine
Published
2022
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94. Vaccino-hésitation – Partie 1: ­Introduction

Author

Zimmermann, Clara, primary, Schmid Thurneysen, Lisa, additional, Deml, Michael J., additional, Wingeier, Bernhard, additional, Gallmann, Caesar, additional, Carp, Peter, additional, Delfino, Alexandre, additional, Gafner, Rebecca, additional, Schudel, Sophie, additional, Engel, Rebecca, additional, Iff, Martin, additional, Hug-Batschelet, Henriette, additional, Schmidt, Martin, additional, Avoledo, Pierino, additional, Etter, Gisela, additional, Huber, Benedikt M., additional, and Tarr, Philip, additional

Published
2022
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95. Impfskepsis – Teil 1: Einführung

Author

Zimmermann, Clara, primary, Schmid Thurneysen, Lisa, additional, Deml, Michael J., additional, Wingeier, Bernhard, additional, Gallmann, Caesar, additional, Carp, Peter, additional, Delfino, Alexandre, additional, Gafner, Rebecca, additional, Schudel, Sophie, additional, Engel, Rebecca, additional, Iff, Martin, additional, Hug-Batschelet, Henriette, additional, Schmidt, Martin, additional, Avoledo, Pierino, additional, Etter, Gisela, additional, Huber, Benedikt M., additional, and Tarr, Philip, additional

Published
2022
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96. Parents’ vaccination information seeking, satisfaction with and trust in medical providers in Switzerland: a mixed-methods study

Author

Ebi, Selina Jana, primary, Deml, Michael J, additional, Jafflin, Kristen, additional, Buhl, Andrea, additional, Engel, Rebecca, additional, Picker, Julia, additional, Häusler, Julia, additional, Wingeier, Bernhard, additional, Krüerke, Daniel, additional, Huber, Benedikt M, additional, Merten, Sonja, additional, and Tarr, Philip E, additional

Published
2022
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97. HPV vaccine awareness, knowledge and information sources among youth in Switzerland: a mixed methods study

Author

Schwendener, Corina L, primary, Kiener, Laura M, additional, Jafflin, Kristen, additional, Rouached, Sarah, additional, Juillerat, Anna, additional, Meier, Vincent, additional, Schärli Maurer, Susanna, additional, Muggli, Franco, additional, Gültekin, Nejla, additional, Baumann, Aron, additional, Debergh, Marlyse, additional, Gruillot, Catherine, additional, Huber, Benedikt, additional, Merten, Sonja, additional, Buhl, Andrea, additional, Deml, Michael J., additional, and Tarr, Philip E., additional

Published
2022
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98. Telomere Length Declines in Persons With Human Immunodeficiency Virus Before Antiretroviral Therapy Start but Not After Viral Suppression: A Longitudinal Study Over &gt;17 Years

Author

Schoepf, Isabella C, primary, Thorball, Christian W, additional, Ledergerber, Bruno, additional, Kootstra, Neeltje A, additional, Reiss, Peter, additional, Raffenberg, Marieke, additional, Engel, Tanja, additional, Braun, Dominique L, additional, Hasse, Barbara, additional, Thurnheer, Christine, additional, Marzolini, Catia, additional, Seneghini, Marco, additional, Bernasconi, Enos, additional, Cavassini, Matthias, additional, Buvelot, Hélène, additional, Arribas, José R, additional, Kouyos, Roger D, additional, Fellay, Jacques, additional, Günthard, Huldrych F, additional, and Tarr, Philip E, additional

Published
2021
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100. Impact of Delaying Antiretroviral Treatment during Primary HIV Infection on Telomere Length

Author

Raffenberg, Marieke, Engel, Tanja, Schoepf, Isabella C, Kootstra, Neeltje A, Reiss, Peter, Braun, Dominique L, Thorball, Christian W, Fellay, Jacques, Kouyos, Roger D, Ledergerber, Bruno, Günthard, Huldrych F, Tarr, Philip E, Zurich Primary HIV Infection Study, Swiss HIV Cohort Study, and University of Zurich

Subjects
10234 Clinic for Infectious Diseases, 10028 Institute of Medical Virology, 610 Medicine & health
Published
2021

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