Author: "Tang, W." - Searchworks@Jio Institute Digital Library Search Results

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18,797 results on '"Tang, W."'

51. Sample Optimization of Fast Authentication of Concentrated Chinese Medicine Granules Using FTIR-ATR with Chemometrics

Author: Fung, S. H., Wong, E. S. W., O, C. Y., Chan, S. M. N., Sze, E. T. P., Tang, W. F., Li, C. H., Lee, F. W. F., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Nagar, Atulya K., editor, Jat, Dharm Singh, editor, Mishra, Durgesh, editor, and Joshi, Amit, editor
Published: 2024
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52. The Development of Internet of Things (IoT) Preventive and Predictive Maintenance Solutions for Building Management

Author: Tang, W. F., Li, C. H., Mak, S. L., Lee, C. C., Lam, Stephen, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Nagar, Atulya K., editor, Jat, Dharm Singh, editor, Mishra, Durgesh, editor, and Joshi, Amit, editor
Published: 2024
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53. Gut Microbial Metabolism in Heart Failure

Author: Aiyer, Sahana, Tang, W. H. Wilson, Lenzi, Andrea, Series Editor, Jannini, Emmanuele A., Series Editor, Federici, Massimo, editor, and Menghini, Rossella, editor
Published: 2024
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54. Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives.

Author: Ni, Hanyu, Jordan, Elizabeth, Kinnamon, Daniel, Cao, Jinwen, Haas, Garrie, Hofmeyer, Mark, Kransdorf, Evan, Ewald, Gregory, Morris, Alanna, Owens, Anjali, Lowes, Brian, Stoller, Douglas, Tang, W, Garg, Sonia, Trachtenberg, Barry, Shah, Palak, Pamboukian, Salpy, Sweitzer, Nancy, Wheeler, Matthew, Wilcox, Jane, Katz, Stuart, Pan, Stephen, Jimenez, Javier, Fishbein, Daniel, Smart, Frank, Gottlieb, Stephen, Judge, Daniel, Moore, Charles, Huggins, Gordon, Hershberger, Ray, and Wang, Jessica
Subjects: dilated cardiomyopathy, family members, screening, Female, Humans, Male, Black People, Cardiomyopathy, Dilated, Echocardiography, Ethnicity, Hispanic or Latino, Hypertrophy, Left Ventricular, Adult, Middle Aged
Abstract: BACKGROUND: Cardiovascular screening is recommended for first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for DCM patients without known familial DCM, for non-White FDRs, or for DCM partial phenotypes of left ventricular enlargement (LVE) or left ventricular systolic dysfunction (LVSD). OBJECTIVES: This study examined the yield of clinical screening among reportedly unaffected FDRs of DCM patients. METHODS: Adult FDRs of DCM patients at 25 sites completed screening echocardiograms and ECGs. Mixed models accounting for site heterogeneity and intrafamilial correlation were used to compare screen-based percentages of DCM, LVSD, or LVE by FDR demographics, cardiovascular risk factors, and proband genetics results. RESULTS: A total of 1,365 FDRs were included, with a mean age of 44.8 ± 16.9 years, 27.5% non-Hispanic Black, 9.8% Hispanic, and 61.7% women. Among screened FDRs, 14.1% had new diagnoses of DCM (2.1%), LVSD (3.6%), or LVE (8.4%). The percentage of FDRs with new diagnoses was higher for those aged 45 to 64 years than 18 to 44 years. The age-adjusted percentage of any finding was higher among FDRs with hypertension and obesity but did not differ statistically by race and ethnicity (16.2% for Hispanic, 15.2% for non-Hispanic Black, and 13.1% for non-Hispanic White) or sex (14.6% for women and 12.8% for men). FDRs whose probands carried clinically reportable variants were more likely to be identified with DCM. CONCLUSIONS: Cardiovascular screening identified new DCM-related findings among 1 in 7 reportedly unaffected FDRs regardless of race and ethnicity, underscoring the value of clinical screening in all FDRs.
Published: 2023

55. Effectiveness of the Family Heart Talk Communication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial.

Author: Kinnamon, Daniel, Jordan, Elizabeth, Haas, Garrie, Hofmeyer, Mark, Kransdorf, Evan, Ewald, Gregory, Morris, Alanna, Owens, Anjali, Lowes, Brian, Stoller, Douglas, Tang, W, Garg, Sonia, Trachtenberg, Barry, Shah, Palak, Pamboukian, Salpy, Sweitzer, Nancy, Wheeler, Matthew, Wilcox, Jane, Katz, Stuart, Pan, Stephen, Jimenez, Javier, Aaronson, Keith, Fishbein, Daniel, Smart, Frank, Wang, Jessica, Gottlieb, Stephen, Judge, Daniel, Moore, Charles, Mead, Jonathan, Huggins, Gordon, Ni, Hanyu, Burke, Wylie, and Hershberger, Ray
Subjects: cardiomyopathy, dilated, health communication, randomized controlled trial, Humans, Cardiomyopathy, Dilated, Ethnicity, Family, Family Health, Risk Assessment
Abstract: BACKGROUND: Managing disease risk among first-degree relatives of probands diagnosed with a heritable disease is central to precision medicine. A critical component is often clinical screening, which is particularly important for conditions like dilated cardiomyopathy (DCM) that remain asymptomatic until severe disease develops. Nonetheless, probands are frequently ill-equipped to disseminate genetic risk information that motivates at-risk relatives to complete recommended clinical screening. An easily implemented remedy for this key issue has been elusive. METHODS: The DCM Precision Medicine Study developed Family Heart Talk, a booklet designed to help probands with DCM communicate genetic risk and the need for cardiovascular screening to their relatives. The effectiveness of the Family Heart Talk booklet in increasing cardiovascular clinical screening uptake among first-degree relatives was assessed in a multicenter, open-label, cluster-randomized, controlled trial. The primary outcome measured in eligible first-degree relatives was completion of screening initiated within 12 months after proband enrollment. Because probands randomized to the intervention received the booklet at the enrollment visit, eligible first-degree relatives were limited to those who were alive the day after proband enrollment and not enrolled on the same day as the proband. RESULTS: Between June 2016 and March 2020, 1241 probands were randomized (1:1) to receive Family Heart Talk (n=621) or not (n=620) within strata defined by site and self-identified race/ethnicity (non-Hispanic Black, non-Hispanic White, or Hispanic). Final analyses included 550 families (n=2230 eligible first-degree relatives) in the Family Heart Talk arm and 561 (n=2416) in the control arm. A higher percentage of eligible first-degree relatives completed screening in the Family Heart Talk arm (19.5% versus 16.0%), and the odds of screening completion among these first-degree relatives were higher in the Family Heart Talk arm after adjustment for proband randomization stratum, sex, and age quartile (odds ratio, 1.30 [1-sided 95% CI, 1.08-∞]). A prespecified subgroup analysis did not find evidence of heterogeneity in the adjusted intervention odds ratio across race/ethnicity strata (P=0.90). CONCLUSIONS: Family Heart Talk, a booklet that can be provided to patients with DCM by clinicians with minimal additional time investment, was effective in increasing cardiovascular clinical screening among first-degree relatives of these patients. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT03037632.
Published: 2023

56. The artificial sweetener erythritol and cardiovascular event risk.

Author: Witkowski, Marco, Nemet, Ina, Alamri, Hassan, Wilcox, Jennifer, Gupta, Nilaksh, Nimer, Nisreen, Haghikia, Arash, Li, Xinmin, Wu, Yuping, Saha, Prasenjit, Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, Cajka, Tomas, Landmesser, Ulf, Tang, W, Hazen, Stanley, and Fiehn, Oliver
Subjects: Humans, Sweetening Agents, Prospective Studies, Erythritol, Myocardial Infarction, Heart
Abstract: Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythritol and atherothrombotic disease risk. In initial untargeted metabolomics studies in patients undergoing cardiac risk assessment (n = 1,157; discovery cohort, NCT00590200 ), circulating levels of multiple polyol sweeteners, especially erythritol, were associated with incident (3 year) risk for major adverse cardiovascular events (MACE; includes death or nonfatal myocardial infarction or stroke). Subsequent targeted metabolomics analyses in independent US (n = 2,149, NCT00590200 ) and European (n = 833, DRKS00020915 ) validation cohorts of stable patients undergoing elective cardiac evaluation confirmed this association (fourth versus first quartile adjusted hazard ratio (95% confidence interval), 1.80 (1.18-2.77) and 2.21 (1.20-4.07), respectively). At physiological levels, erythritol enhanced platelet reactivity in vitro and thrombosis formation in vivo. Finally, in a prospective pilot intervention study ( NCT04731363 ), erythritol ingestion in healthy volunteers (n = 8) induced marked and sustained (>2 d) increases in plasma erythritol levels well above thresholds associated with heightened platelet reactivity and thrombosis potential in in vitro and in vivo studies. Our findings reveal that erythritol is both associated with incident MACE risk and fosters enhanced thrombosis. Studies assessing the long-term safety of erythritol are warranted.
Published: 2023

57. Search for boosted keV-MeV light dark matter particles from evaporating primordial black holes at the CDEX-10 experiment

Author: Zhang, Z. H., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Karmakar, S., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, J. X., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: We present novel constraints on boosted light dark matter particles (denoted as ``$\chi$'') from evaporating primordial black holes (PBHs) using 205.4 kg$\cdot$day data from the China Jinping Underground Laboratory's CDEX-10 p-type point contact germanium detector with a 160 eVee analysis threshold. $\chi$ from PBHs with masses ranging from 1$\times$10$^{15}$ g to 7$\times$10$^{16}$ g are searched in this work. In the presence of PBH abundance compatible with present bounds, our result excludes the $\chi$-nucleon elastic-scattering cross section region from 3.4$\times$10$^{-32}$ cm$^{2}$ to 2.3$\times$10$^{-29}$ cm$^{2}$ for $\chi$ of 1 keV to 24 MeV from PBHs with masses of 5$\times$10$^{15}$ g, as well as from 1.1$\times$10$^{-28}$ cm$^{2}$ to 7.6$\times$10$^{-28}$ cm$^{2}$ for $\chi$ of 1 keV to 0.6 MeV from PBHs with masses of 7$\times$10$^{16}$ g. If the $\chi$-nucleon elastic-scattering cross section can be determined in the future, the abundance of PBHs may be severely constrained by $\chi$ evaporation. With the lower threshold (160 eVee) of the CDEX-10 experiment compared to the previously used experiments, this work allows for a better reach at soft spectra produced by heavier PBHs, which demonstrates the vast potential of such a technical route to pursue $\chi$ from larger PBHs with a low threshold., Comment: 8 pages, 6 figures. Version updated to match PRD version
Published: 2022
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58. First Measurement of Differential Cross Sections for Muon Neutrino Charged Current Interactions on Argon with a Two-proton Final State in the MicroBooNE Detector

Author: MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: We present the first measurement of differential cross sections for charged-current muon neutrino interactions on argon with one muon, two protons, and no pions in the final state. Such interactions leave the target nucleus in a two-particle two-hole state; these states are of great interest, but currently there is limited information about their production in neutrino-nucleus interactions. Detailed investigations of the production of two-particle two-hole states are vital to support upcoming experiments exploring the nature of the neutrino, and the development of the liquid-argon time-projection-chamber has made possible the isolation of such final states. The opening angle between the two protons, the angle between the total proton momentum and the muon, and the total transverse momentum of the final state system are sensitive to the underlying physics processes as embodied in a variety of models. Realistic initial-state momentum distributions are shown to be important in reproducing the data., Comment: Resubmitted to PRL in response to reviewer comments
Published: 2022

59. First constraints on light sterile neutrino oscillations from combined appearance and disappearance searches with the MicroBooNE detector

Author: MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.
Subjects: High Energy Physics - Experiment
Abstract: We present a search for eV-scale sterile neutrino oscillations in the MicroBooNE liquid argon detector, simultaneously considering all possible appearance and disappearance effects within the $3+1$ active-to-sterile neutrino oscillation framework. We analyze the neutrino candidate events for the recent measurements of charged-current $\nu_e$ and $\nu_{\mu}$ interactions in the MicroBooNE detector, using data corresponding to an exposure of 6.37$\times$10$^{20}$ protons on target from the Fermilab booster neutrino beam. We observe no evidence of light sterile neutrino oscillations and derive exclusion contours at the $95\%$ confidence level in the plane of the mass-squared splitting $\Delta m^2_{41}$ and the sterile neutrino mixing angles $\theta_{\mu e}$ and $\theta_{ee}$, excluding part of the parameter space allowed by experimental anomalies. Cancellation of $\nu_e$ appearance and $\nu_e$ disappearance effects due to the full $3+1$ treatment of the analysis leads to a degeneracy when determining the oscillation parameters, which is discussed in this paper and will be addressed by future analyses., Comment: 9 pages, 4 figures; supplemental: 6 pages, 8 figures
Published: 2022
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60. Search for exotic interactions of solar neutrinos in the CDEX-10 experiment

Author: Geng, X. P., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Karmakar, S., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, J. X., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: We investigate exotic neutrino interactions using the 205.4 kg$\cdot$day dataset from the CDEX-10 experiment at the China Jinping Underground Laboratory. New constraints on the mass and couplings of new gauge bosons are presented. Two nonstandard neutrino interactions are considered: a $U(1)_{B-L}$ gauge-boson-induced interaction between an active neutrino and electron/nucleus, and a dark-photon-induced interaction between a sterile neutrino and electron/nucleus via kinetic mixing with a photon. This work probes an unexplored parameter space involving sterile neutrino coupling with a dark photon. New laboratory limits are derived on dark photon masses below $1~{\rm eV}/c^{2}$ at some benchmark values of $\Delta m_{41}^{2}$ and $g^{\prime2}{\rm{sin}}^{2}2\theta_{14}$., Comment: 6 pages, 4 figures. Version updated to match PRD version
Published: 2022
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61. Design of the ECCE Detector for the Electron Ion Collider

Author: Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Conroy, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C. T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Gwenian, C., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P. -h. J., Huang, J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C. E., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, X., Liang, Y. T., Lim, S., Lin, C. -H., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Orešić, S., Osborn, J. D., O'Shaughnessy, C., Paganis, S., Papandreou, Z, Pate, S. F., Patel, M., Paus, C., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K., Røed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zhang, J., Zhang, Y., Zhao, Y. X., Zheng, X., and Zhuang, P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The EIC Comprehensive Chromodynamics Experiment (ECCE) detector has been designed to address the full scope of the proposed Electron Ion Collider (EIC) physics program as presented by the National Academy of Science and provide a deeper understanding of the quark-gluon structure of matter. To accomplish this, the ECCE detector offers nearly acceptance and energy coverage along with excellent tracking and particle identification. The ECCE detector was designed to be built within the budget envelope set out by the EIC project while simultaneously managing cost and schedule risks. This detector concept has been selected to be the basis for the EIC project detector., Comment: 34 pages, 30 figures, 9 tables
Published: 2022

62. Exotic Dark Matter Search with CDEX-10 Experiment at China's Jinping Underground Laboratory

Author: Dai, W. H., Jia, L. P., Ma, H., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Karmakar, S., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yang, L. T., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: A search for exotic dark matter (DM) in the sub-GeV mass range has been conducted using 205 kg$\cdot$day data taken from a p-type point contact germanium detector of CDEX-10 experiment at China Jinping underground laboratory. New low-mass dark matter searching channels, neutral current fermionic DM absorption ($\chi+A\rightarrow \nu+A$) and DM-nucleus 3$\rightarrow$2 scattering ($\chi+\chi+A\rightarrow \phi+A$), have been analyzed with an energy threshold of 160 eVee. No significant signal was found. Thus new limits on the DM-nucleon interaction cross section are set for both models at sub-GeV DM mass region. A cross section limit for the fermionic DM absorption is set to be $\rm 2.5\times 10^{-46} cm^2$(90\% C.L.) at DM mass of 10 MeV/c$^2$. For the DM-nucleus 3$\rightarrow$2 scattering scenario, limits are extended to DM mass of 5 MeV/c$^2$ and 14 MeV/c$^2$ for the massless dark photon and bound DM final state, respectively., Comment: 5 pages, 7 figures
Published: 2022
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63. Syntheses, Crystal Structure, and Properties of Two New Coordination Polymers from a Triphenylamino-Based Ligand

Author: Cai, Q., Su, J., Tang, W. B., and You, X. H.
Published: 2024
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64. A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

Author: Ferrell, Marc, Wang, Zeneng, Anderson, James T., Li, Xinmin S., Witkowski, Marco, DiDonato, Joseph A., Hilser, James R., Hartiala, Jaana A., Haghikia, Arash, Cajka, Tomas, Fiehn, Oliver, Sangwan, Naseer, Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, Landmesser, Ulf, Tang, W. H. Wilson, Allayee, Hooman, and Hazen, Stanley L.
Published: 2024
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65. Automated human induced pluripotent stem cell culture and sample preparation for 3D live-cell microscopy

Author: Gregor, Benjamin W., Coston, Mackenzie E., Adams, Ellen M., Arakaki, Joy, Borensztejn, Antoine, Do, Thao P., Fuqua, Margaret A., Haupt, Amanda, Hendershott, Melissa C., Leung, Winnie, Mueller, Irina A., Nath, Aditya, Nelson, Angelique M., Rafelski, Susanne M., Sanchez, Emmanuel E., Swain-Bowden, Madison J., Tang, W. Joyce, Thirstrup, Derek J., Wiegraebe, Winfried, Whitney, Brian P., Yan, Calysta, Gunawardane, Ruwanthi N., and Gaudreault, Nathalie
Published: 2024
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66. Pediatricians’ Perspectives on Introducing Transitional Care into Handover Between Pediatric Intensive Care Units and General Wards

Author: Ji J, Yang L, Yang H, Zeng C, Tang W, and Lu Q
Subjects: pediatric intensive care unit, pediatricians, transitional care, qualitative study, Medicine (General), R5-920
Abstract: Jianlin Ji,1,&ast; Liling Yang,2,&ast; Hanlin Yang,1 Chengxi Zeng,1 Wenjuan Tang,2 Qunfeng Lu1,3 1School of Nursing, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Nursing Department, Children’s Hospital of Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Department of Nursing, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qunfeng Lu, Department of Nursing, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China, Email luluroom2004@163.com Wenjuan Tang, Nursing department, Children’s Hospital of Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Email wjtang2014@163.comBackground: Despite the availability of a considerable number of studies on transitional care, few qualitative studies have synthesized physicians’ perspectives on PICU-to-ward transition to develop a comprehensive transitional care curriculum. The aim of this study is to explore physicians’ perceptions and management of the transition of critically ill children from the PICU to the general ward, with the aim of providing an evidence-based curriculum.Methods: A qualitative study was conducted between July and August 2022. The study involved semi-structured interviews with 11 participants, and data analysis was carried out using NVivo 12.0 software through thematic analysis method.Results: Based on the data analysis, three main themes were identified: recognition of professional roles during transition, difficulties during implementation transitional care and suggestions for improving transitional care.Conclusion: The insights of doctors can be valuable in improving transitional care for critically ill children during PICU-to-Ward transition and in developing relevant curricula. It is essential to introduce standardized clinical pathways and strengthen curricula on critical elements, including communication and follow-up.Keywords: pediatric intensive care unit, pediatricians, transitional care, qualitative study
Published: 2024

67. Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis

Author: Zhou Y, Yang Y, Yi L, Pan M, Tang W, and Duan H
Subjects: propofol, dexmedetomidine, endotoxemia, encephalopathy, ferroptosis, Therapeutics. Pharmacology, RM1-950
Abstract: Ye Zhou, Yangliang Yang, Liang Yi, Mengzhi Pan, Weiqing Tang, Hongwei Duan Department of Anesthesiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People’s Republic of ChinaCorrespondence: Hongwei Duan, Email duanhongwei120@126.comBackground: Sepsis is recognized as a multiorgan and systemic damage caused by dysregulated host response to infection. Its acute systemic inflammatory response highly resembles that of lipopolysaccharide (LPS)-induced endotoxemia. Propofol and dexmedetomidine are two commonly used sedatives for mechanical ventilation in critically ill patients and have been reported to alleviate cognitive impairment in many diseases. In this study, we aimed to explore and compare the effects of propofol and dexmedetomidine on the encephalopathy induced by endotoxemia and to investigate whether ferroptosis is involved, finally providing experimental evidence for multi-drug combination in septic sedation.Methods: A total of 218 C57BL/6J male mice (20– 25 g, 6– 8 weeks) were used. Morris water maze (MWM) tests were performed to evaluate whether propofol and dexmedetomidine attenuated LPS-induced cognitive deficits. Brain injury was evaluated using Nissl and Fluoro-Jade C (FJC) staining. Neuroinflammation was assessed by dihydroethidium (DHE) and DCFH-DA staining and by measuring the levels of three cytokines. The number of Iba1+ and GFAP+ cells was used to detect the activation of microglia and astrocytes. To explore the involvement of ferroptosis, the levels of ptgs2 and chac1; the content of iron, malondialdehyde (MDA), and glutathione (GSH); and the expression of ferroptosis-related proteins were investigated.Conclusion: The single use of propofol and dexmedetomidine mitigated LPS-induced cognitive impairment, while the combination showed poor performance. In alleviating endotoxemic neural loss and degeneration, the united sedative group exhibited the most potent capability. Both propofol and dexmedetomidine inhibited neuroinflammation, while propofol’s effect was slightly weaker. All sedative groups reduced the neural apoptosis, inhibited the activation of microglia and astrocytes, and relieved neurologic ferroptosis. The combined group was most prominent in combating genetic and biochemical alterations of ferroptosis. Fpn1 may be at the core of endotoxemia-related ferroptosis activation.Keywords: propofol, dexmedetomidine, endotoxemia, encephalopathy, ferroptosis
Published: 2024

68. Effects of Anti-Seizure Medication on Neuregulin-1 Gene and Protein in Patients with First-Episode Focal Epilepsy

Author: Zhao X, Huang G, Xie Z, Mo Y, Zhu H, Gao Y, Han Y, and Tang W
Subjects: neuregulin-1, focal epilepsy, drug treatment, pathophysiology, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Xin Zhao,1,2 Guijiang Huang,2 Zhenrong Xie,2 Yaxiong Mo,3 Hongxuan Zhu,2 Yajie Gao,2 Yanbing Han,4 Wei Tang2 1Department of Pharmacy, The Third Affiliated Hospital of Inner Mongolia Medical University, Baotou, People’s Republic of China; 2Department of Science and Education, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; 3Department of Pediatrics, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; 4Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of ChinaCorrespondence: Wei Tang, Department of Science and Education, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China, Email tangw666@sina.com Yanbing Han, Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China, Email ynhyb@163.comIntroduction: Neuregulin-1 (NRG-1) appears to play a role in the pathogenesis of several neuropsychiatric disorders, including epilepsy. We conducted a study to investigate the effect of anti-seizure medication on NRG-1 mRNA and NRG-1 protein levels in patients with first-episode focal epilepsy.Methods: The levels of NRG-1 mRNA isoforms (type I, II, III, and IV) in peripheral blood mononuclear cells (PBMCs) of 39 healthy controls, 39 first-episode focal epilepsy patients before anti-seizure medication (ASM) therapy and four weeks after administration of ASM were measured by RT-qPCR, and the levels of NRG-1 protein in the serum of samples of each group were determined using ELISA. In addition the relationship between efficacy, NRG-1 mRNA expression, and NRG-1 protein expression was analyzed.Results: The levels of NRG-1 mRNA progressively increased in patients with first-episode focal epilepsy treated with ASM and were distinctly different from those before medication, but remained lower than in healthy controls (all P < 0.001). Before and after drug administration, NRG-1 protein levels were substantially higher in epileptic patients than in healthy controls, and no significant changes were detected with prolonged follow-up (P < 0.001). Patients with epilepsy who utilized ASM were able to control seizures with an overall efficacy of 97.4%. There was a negative correlation between NRG-1 mRNA levels and efficacy: as NRG-1 mRNA levels increased, seizures reduced (all P < 0.05).Conclusion: Our research indicated that NRG-1 may play a role in the pathophysiology of epilepsy. NRG-1 mRNA may provide ideas for the discovery of novel epilepsy therapeutic markers and therapeutic targets for novel ASM.Keywords: neuregulin-1, focal epilepsy, drug treatment, pathophysiology
Published: 2024

69. Metabolic Syndrome and Tendon Disease: A Comprehensive Review

Author: Lai C, Li R, Tang W, Liu J, Duan XD, Bao D, Liu H, and Fu S
Subjects: metabolic syndrome, tendon, diabetes mellitus, hyperlipidemia, obesity, hypertension., Specialties of internal medicine, RC581-951
Abstract: Canhao Lai,1,&ast; Ruichen Li,1,&ast; Weili Tang,1 Jinyu Liu,1 Xinfang DXF Duan,1 Dingsu Bao,1,2 Huan Liu,1 Shijie Fu1 1Department of Bone and Joint, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, People’s Republic of China; 2Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shijie Fu; Huan Liu, Department of Bone and Joint, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, No. 182, Chunhui Road, Longmatan District, Luzhou, Sichuan, 646000, People’s Republic of China, Tel +86 13882759783, Email fushijieggj@126.com; 20016040@163.comAbstract: Metabolic syndrome (MS) is a multifaceted pathological condition characterized by the atypical accumulation of various metabolic components such as central obesity or excess weight, hyperlipidemia, low-density lipoprotein (LDL), hypertension, and insulin resistance. Recently, MS has been recognized as a notable contributor to heart and circulatory diseases. In addition, with increasing research, the impact of MS on tendon repair and disease has gradually emerged. Recent studies have investigated the relationship between tendon healing and diseases such as diabetes, dyslipidemia, obesity, and other metabolic disorders. However, diabetes mellitus (DM), hypercholesterolemia, obesity, and various metabolic disorders often coexist and together constitute MS. At present, insulin resistance is considered the major pathological mechanism underlying MS, central obesity is regarded as the predominant factor responsible for it, and dyslipidemia and other metabolic diseases are known as secondary contributors to MS. This review aims to evaluate the current literature regarding the impact of various pathological conditions in MS on tendon recovery and illness, and to present a comprehensive overview of the effects of MS on tendon recovery and diseases, along with the accompanying molecular mechanisms.Keywords: metabolic syndrome, tendon, diabetes mellitus, hyperlipidemia, obesity, hypertension
Published: 2024

70. Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway

Author: Yang Y, Yao Z, Zhang J, Shao W, Li B, Wu H, and Tang W
Subjects: mrsa, peptidoglycan hydrolase, homeostasis, autolysis, nod2, Infectious and parasitic diseases, RC109-216
Abstract: Yang Yang,1,2 Zongze Yao,1 Jiazhen Zhang,1 Wei Shao,3 Bo Li,2 Huihui Wu,2 Wenjian Tang,3 Jing Zhang2 1School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2Anhui Province Key Laboratory of Occupational Health, Anhui No.2 Provincial People’s Hospital, Hefei, People’s Republic of China; 3School of Pharmacy, Anhui Medical University, Hefei, People’s Republic of ChinaCorrespondence: Wenjian Tang; Jing Zhang, Tel +86-551-63672601, Email ahmupharm@126.com; hfzj2552@163.comBackground: Methicillin-resistant Staphylococcus aureus (MRSA) is a cause of staph infection that is difficult to treat because of resistance to some antibiotics. A recent study indicated that diarylurea ZJ-2 is a novel antibacterial agent against multi-drug resistant Enterococcus faecium. In this work, we refined the bactericidal mechanism of ZJ-2 as a peptidoglycan (PG) hydrolase by affecting AtlA-mediated PG homeostasis.Methods: A wild-type strain (WT) and a mutant strain (ΔatlA) were used to investigate the effects of ZJ-2 on the cell wall, PG, and autolysin regulatory system by antimicrobial susceptibility testing, hemolytic toxin assay, microanalysis, autolysis assay, qRT-PCR, ELISA and mouse model of pneumonia.Results: The results revealed that ZJ-2 down-regulated the expression of genes related to peptidoglycan hydrolase (PGH) (sprX, walR, atlA, and lytM), and reduced the levels of PG, muramyl dipeptide (MDP), cytokines, and hemolytic toxin, while ΔatlA interfered with the genes regulation and PG homeostasis. In the mouse MRSA pneumonia model, the same trend was observed in the nucleotide oligomerization domain protein 2 (NOD2) and relative proinflammatory factors.Conclusion: ZJ-2 may act as a novel inhibitor of PG hydrolyse, disrupting autolysin-mediated PG homeostasis, and reducing inflammation by down-regulating the MDP-NOD2 pathway. Keywords: MRSA, peptidoglycan hydrolase, homeostasis, autolysis, NOD2
Published: 2024

71. Exploring the Experiences and Support of Nurses as Second Victims After Patient Safety Events in China: A Mixed-Method Approach

Author: Tang W, Xie Y, Yan Q, Teng Y, Yu L, Wei L, Li J, Chen Y, Huang X, Yang S, and Jia K
Subjects: nurses, second victims, patient safety events, mixed method, Public aspects of medicine, RA1-1270
Abstract: Wenzhen Tang,1 Yuanxi Xie,1 Qingfeng Yan,2 Yanjuan Teng,1 Li Yu,1 Liuying Wei,3 Jinmei Li,4 Yuhui Chen,1 Xiaolin Huang,1 Shaoli Yang,1 Kui Jia1 1The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 2The Sanming Second Hospital, Sanming, Fujian Province, 366099, People’s Republic of China; 3Nanning Fourth People’s Hospital, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 4Wanxiu District Chengnan Community Health Service Center, Wuzhou, Guangxi Zhuang Autonomous Region, 543000, People’s Republic of ChinaCorrespondence: Kui Jia, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China, Email 1960728884@qq.comAim: To investigate the current status of experience and support of nurses as second victims and explore its related factors in nurses.Design: A sequential, explanatory, mixed-method study was applied.Methods: A total of 406 nurses from seven tertiary hospitals in China were chosen as participants between September to October 2023. The Chinese version of the Second Victim Experience and Support Questionnaire (SVEST), Somatic Complaints of Sub-health Status Questionnaire (SCSSQ) and Generalized Anxiety Disorder (GAD-7) were applied to collect quantitative data. Eight nurses were selected for a qualitative study through in-depth interviews. Through interpretive phenomenological analysis, the interview data were analysed to explore the experience and support of nurses as second victims.Results: Practice distress (15.74 ± 4.97) and psychological distress (15.48 ± 3.74) were the highest dimensions, indicating Chinese nurses experienced second victim-related practice and psychological distress. Nurses with different gender, age, education, marital status, income, working hours, professional titles, and unit types have different levels of second victim-related experience and support (p
Published: 2024

72. Obstructive Fibrinous Tracheal Pseudomembrane Following Repeated Intratracheal Interventions

Author: Tang W, Zhou W, and Zheng X
Subjects: pseudomembrane, oftp, intratracheal interventions, intubation, dyspnea, Medicine (General), R5-920
Abstract: Wei Tang, Wenlai Zhou,&ast; Xiangde Zheng&ast; Department of Critical Care Medicine, Dazhou Central Hospital, Dazhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wenlai Zhou; Xiangde Zheng, Department of Critical Care Medicine, Dazhou Central Hospital, Dazhou, 635000, People’s Republic of China, Email Zhouwl1218@163.com; zxdfq123@163.comAbstract: Obstructive fibrinous tracheal pseudomembrane (OFTP) is a relatively rare complication of endotracheal intubation. Despite being well documented, the exact pathogenesis of OFTP remains unclear. Some studies suggest that it may arise from the early stage of ischemic tracheal wall injury caused by the cuff pressure during intubation. Diagnosis and treatment of OFTP can be facilitated through therapeutic bronchoscopy. In this case report, we describe a patient who presented with dyspnea following repeated intratracheal interventions and was diagnosed with OFTP. The patient was successfully treated with bronchoscopic cryotherapy and was subsequently discharged from the hospital.Keywords: pseudomembrane, OFTP, intratracheal interventions, intubation, dyspnea
Published: 2024

73. Detector Requirements and Simulation Results for the EIC Exclusive, Diffractive and Tagging Physics Program using the ECCE Detector Concept

Author: Bylinkin, A., Dean, C. T., Fegan, S., Gangadharan, D., Gates, K., Kay, S. J. D., Korover, I., Li, W. B., Li, X., Montgomery, R., Nguyen, D., Penman, G., Pybus, J. R., Santiesteban, N., Trotta, R., Usman, A., Baker, M. D., Frantz, J., Glazier, D. I., Higinbotham, D. W., Horn, T., Huang, J., Huber, G., Reed, R., Roche, J., Schmidt, A., Steinberg, P., Stevens, J., Goto, Y., Camacho, C. Munoz, Murray, M., Papandreou, Z., Zha, W., Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Demarteau, M., Diehl, S., Doshita, N., Dupre, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Finger, M., Finger Jr., M., Friedman, M., Friscic, I., Gardner, S., Geurts, F., Gilman, R., Glimos, E., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Hoballah, M., Hoghmrtsyan, A., Hsu, P. -h. J., Hutson, A., Hwang, K. Y., Hyde, C. E., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Liang, Y. T., Lim, S., Lin, C. -h., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Mantry, S., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Morrison, D., Movsisyan, A., Mkrtchyan, H., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Oresic, S., Osborn, J. D., O'Shaughnessy, C., Paganis, S., Pate, S. F., Patel, M., Paus, C., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K. F., Roed, K., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santos, R., Sarsour, M., Schambach, J., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Stepanov, P., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Tveter, T. S., Umaka, E., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zhang, J. -L., and Zhang, J. -X.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: This article presents a collection of simulation studies using the ECCE detector concept in the context of the EIC's exclusive, diffractive, and tagging physics program, which aims to further explore the rich quark-gluon structure of nucleons and nuclei. To successfully execute the program, ECCE proposed to utilize the detecter system close to the beamline to ensure exclusivity and tag ion beam/fragments for a particular reaction of interest. Preliminary studies confirmed the proposed technology and design satisfy the requirements. The projected physics impact results are based on the projected detector performance from the simulation at 10 or 100 fb^-1 of integrated luminosity. Additionally, a few insights on the potential 2nd Interaction Region can (IR) were also documented which could serve as a guidepost for the future development of a second EIC detector.
Published: 2022
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74. Differential cross section measurement of charged current $\nu_{e}$ interactions without final-state pions in MicroBooNE

Author: MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.
Subjects: High Energy Physics - Experiment
Abstract: In this letter we present the first measurements of an exclusive electron neutrino cross section with the MicroBooNE experiment using data from the Booster Neutrino Beamline at Fermilab. These measurements are made for a selection of charged-current electron neutrinos without final-state pions. Differential cross sections are extracted in energy and angle with respect to the beam for the electron and the leading proton. The differential cross section as a function of proton energy is measured using events with protons both above and below the visibility threshold. This is done by including a separate selection of electron neutrino events without reconstructed proton candidates in addition to those with proton candidates. Results are compared to the predictions from several modern generators, and we find the data agrees well with these models. The data shows best agreement, as quantified by $p$-value, with the generators that predict a lower overall cross section, such as GENIE v3 and NuWro.
Published: 2022

75. ECCE unpolarized TMD measurements

Author: Seidl, R., Vladimirov, A., Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C. T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P. -h. J., Huang, J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C. E., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, X., Liang, Y. T., Lim, S., Lin, C. -H., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Orešić, S., Osborn, J. D., O'Shaughnessy, C., Paganis, S., Papandreou, Z, Pate, S. F., Patel, M., Paus, C., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K., Røed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zhang, J., Zhang, Y., Zhao, Y. X., Zheng, X., and Zhuang, P.
Subjects: High Energy Physics - Experiment
Abstract: We performed feasibility studies for various measurements that are related to unpolarized TMD distribution and fragmentation functions. The processes studied include semi-inclusive Deep inelastic scattering (SIDIS) where single hadrons (pions and kaons) were detected in addition to the scattered DIS lepton. The single hadron cross sections and multiplicities were extracted as a function of the DIS variables $x$ and $Q^2$, as well as the semi-inclusive variables $z$, which corresponds to the momentum fraction the detected hadron carries relative to the struck parton and $P_T$, which corresponds to the transverse momentum of the detected hadron relative to the virtual photon. The expected statistical precision of such measurements is extrapolated to accumulated luminosities of 10 fb$^{-1}$ and potential systematic uncertainties are approximated given the deviations between true and reconstructed yields., Comment: 12 pages, 9 figures, to be submitted in joint ECCE proposal NIM-A volume
Published: 2022
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76. ECCE Sensitivity Studies for Single Hadron Transverse Single Spin Asymmetry Measurements

Author: Seidl, R., Vladimirov, A., Pitonyak, D., Prokudin, A., Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C. T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P. -h. J., Huang, J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C. E., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, X., Liang, Y. T., Lim, S., Lin, C. -H., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Orešić, S., Osborn, J. D., O'Shaughnessy, C., Paganis, S., Papandreou, Z, Pate, S. F., Patel, M., Paus, C., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K., Røed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zhang, J., Zhang, Y., Zhao, Y. X., Zheng, X., and Zhuang, P.
Subjects: High Energy Physics - Experiment
Abstract: We performed feasibility studies for various single transverse spin measurements that are related to the Sivers effect, transversity and the tensor charge, and the Collins fragmentation function. The processes studied include semi-inclusive deep inelastic scattering (SIDIS) where single hadrons (pions and kaons) were detected in addition to the scattered DIS lepton. The data were obtained in {\sc pythia}6 and {\sc geant}4 simulated e+p collisions at 18 GeV on 275 GeV, 18 on 100, 10 on 100, and 5 on 41 that use the ECCE detector configuration. Typical DIS kinematics were selected, most notably $Q^2 > 1 $ GeV$^2$, and cover the $x$ range from $10^{-4}$ to $1$. The single spin asymmetries were extracted as a function of $x$ and $Q^2$, as well as the semi-inclusive variables $z$, and $P_T$. They are obtained in azimuthal moments in combinations of the azimuthal angles of the hadron transverse momentum and transverse spin of the nucleon relative to the lepton scattering plane. The initially unpolarized MonteCarlo was re-weighted in the true kinematic variables, hadron types and parton flavors based on global fits of fixed target SIDIS experiments and $e^+e^-$ annihilation data. The expected statistical precision of such measurements is extrapolated to 10 fb$^{-1}$ and potential systematic uncertainties are approximated given the deviations between true and reconstructed yields. The impact on the knowledge of the Sivers functions, transversity and tensor charges, and the Collins function has then been evaluated in the same phenomenological extractions as in the Yellow Report. The impact is found to be comparable to that obtained with the parameterized Yellow Report detector and shows that the ECCE detector configuration can fulfill the physics goals on these quantities., Comment: 22 pages, 22 figures, to be submitted to joint ECCE proposal NIM-A volume
Published: 2022
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77. Open Heavy Flavor Studies for the ECCE Detector at the Electron Ion Collider

Author: Li, X., Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C. T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P. -h. J., Huang, J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C. E., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, W. B., Liang, Y. T., Lim, S., Lin, C. -H., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Mantry, S., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Orešić, S., Osborn, J. D., O'Shaughnessy, C., Paganis, S., Papandreou, Z., Pate, S. F., Patel, M., Paus, C., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K. F., Røed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zha, W., Zhang, J. -L., Zhang, J. -X., Zhang, Y., Zhao, Y. -X., Zheng, X., and Zhuang, P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract: The ECCE detector has been recommended as the selected reference detector for the future Electron-Ion Collider (EIC). A series of simulation studies have been carried out to validate the physics feasibility of the ECCE detector. In this paper, detailed studies of heavy flavor hadron and jet reconstruction and physics projections with the ECCE detector performance and different magnet options will be presented. The ECCE detector has enabled precise EIC heavy flavor hadron and jet measurements with a broad kinematic coverage. These proposed heavy flavor measurements will help systematically study the hadronization process in vacuum and nuclear medium especially in the underexplored kinematic region., Comment: Open heavy flavor studies with the EIC reference detector design by the ECCE consortium. 11 pages, 11 figures, to be submitted to the Nuclear Instruments and Methods A
Published: 2022

78. Exclusive J/$\psi$ Detection and Physics with ECCE

Author: Li, X., Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C. T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P. -h. J., Huang, J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C. E., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, W. B., Liang, Y. T., Lim, S., Lin, C. -H., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Mantry, S., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Orešić, S., Osborn, J. D., O'Shaughnessy, C., Paganis, S., Papandreou, Z., Pate, S. F., Patel, M., Paus, C., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K. F., Røed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zha, W., Zhang, J. -L., Zhang, J. -X., Zhang, Y., Zhao, Y. -X., Zheng, X., and Zhuang, P.
Subjects: Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract: Exclusive heavy quarkonium photoproduction is one of the most popular processes in EIC, which has a large cross section and a simple final state. Due to the gluonic nature of the exchange Pomeron, this process can be related to the gluon distributions in the nucleus. The momentum transfer dependence of this process is sensitive to the interaction sites, which provides a powerful tool to probe the spatial distribution of gluons in the nucleus. Recently the problem of the origin of hadron mass has received lots of attention in determining the anomaly contribution $M_{a}$. The trace anomaly is sensitive to the gluon condensate, and exclusive production of quarkonia such as J/$\psi$ and $\Upsilon$ can serve as a sensitive probe to constrain it. In this paper, we present the performance of the ECCE detector for exclusive J/$\psi$ detection and the capability of this process to investigate the above physics opportunities with ECCE., Comment: 11 pages, 14 figures, 1 table
Published: 2022
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79. Search for $e\to\tau$ Charged Lepton Flavor Violation at the EIC with the ECCE Detector

Author: Zhang, J. -L., Mantry, S., Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C. T., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P. -h. J., Huang, J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C. E., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, W. B., Li, X., Liang, Y. T., Lim, S., Lin, C. -H., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Orešić, S., Osborn, J. D., O'Shaughnessy, C., Paganis, S., Papandreou, Z., Pate, S. F., Patel, M., Paus, C., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K. F., Røed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zha, W., Zhang, J. -X., Zhang, Y., Zhao, Y. -X., Zheng, X., and Zhuang, P.
Subjects: High Energy Physics - Phenomenology
Abstract: The recently approved Electron-Ion Collider (EIC) will provide a unique new opportunity for searches of charged lepton flavor violation (CLFV) and other new physics scenarios. In contrast to the $e \leftrightarrow \mu$ CLFV transition for which very stringent limits exist, there is still a relatively large discovery space for the $e \to \tau$ CLFV transition, potentially to be explored by the EIC. With the latest detector design of ECCE (EIC Comprehensive Chromodynamics Experiment) and projected integral luminosity of the EIC, we find the $\tau$-leptons created in the DIS process $ep\to \tau X$ are expected to be identified with high efficiency. A first ECCE simulation study, restricted to the 3-prong $\tau$-decay mode and with limited statistics for the Standard Model backgrounds, estimates that the EIC will be able to improve the current exclusion limit on $e\to \tau$ CLFV by an order of magnitude., Comment: 11 pages, 8 figures, to be submitted to NIM
Published: 2022
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80. Design and Simulated Performance of Calorimetry Systems for the ECCE Detector at the Electron Ion Collider

Author: Bock, F., Schmidt, N., Wang, P. K., Santiesteban, N., Horn, T., Huang, J., Lajoie, J., Camacho, C. Munoz, Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C. T., Demarteau, M., Diehl, S., Doshita, N., Dupre, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fanelli, C., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Hoghmrtsyan, A., Hsu, P. -h. J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C. E., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, W. B., Li, X., Liang, Y. T., Lim, S., Lin, C. -h., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Mantry, S., Marchand, D., Marcisovsky, M., Markert, C., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Oresic, S., Osborn, J. D., Shaughnessy, C. O, Paganis, S., Papandreou, Z., Pate, S. F., Patel, M., Paus, C., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K. F., Røed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Thomas, D., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zha, W., Zhang, J. -L., Zhang, J. -X., Zhang, Y., Zhao, Y. -X., Zheng, X., and Zhuang, P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract: We describe the design and performance the calorimeter systems used in the ECCE detector design to achieve the overall performance specifications cost-effectively with careful consideration of appropriate technical and schedule risks. The calorimeter systems consist of three electromagnetic calorimeters, covering the combined pseudorapdity range from -3.7 to 3.8 and two hadronic calorimeters. Key calorimeter performances which include energy and position resolutions, reconstruction efficiency, and particle identification will be presented., Comment: 19 pages, 22 figures, 5 tables
Published: 2022
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81. Search for long-lived heavy neutral leptons and Higgs portal scalars decaying in the MicroBooNE detector

Author: MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.
Subjects: High Energy Physics - Experiment
Abstract: We present a search for long-lived Higgs portal scalars (HPS) and heavy neutral leptons (HNL) decaying in the MicroBooNE liquid-argon time projection chamber. The measurement is performed using data collected synchronously with the NuMI neutrino beam from Fermilab's Main Injector with a total exposure corresponding to $7.01 \times 10^{20}$ protons on target. We set upper limits at the $90\%$ confidence level on the mixing parameter $\lvert U_{\mu 4}\rvert^2$ ranging from $\lvert U_{\mu 4}\rvert^2<12.9\times 10^{-8}$ for Majorana HNLs with a mass of $m_{\rm HNL}=246$ MeV to $\lvert U_{\mu 4}\rvert^2<0.92 \times 10^{-8}$ for $m_{\rm HNL}=385$ MeV, assuming $\lvert U_{e 4}\rvert^2 = \lvert U_{\tau 4}\rvert^2 = 0$ and HNL decays into $\mu^\pm\pi^\mp$ pairs. These limits on $\lvert U_{\mu 4}\rvert^2$ represent an order of magnitude improvement in sensitivity compared to the previous MicroBooNE result. We also constrain the scalar-Higgs mixing angle $\theta$ by searching for HPS decays into $\mu^+\mu^-$ final states, excluding a contour in the parameter space with lower bounds of $\theta^2<31.3 \times 10^{-9}$ for $m_{\rm HPS}=212$ GeV and $\theta^2<1.09 \times 10^{-9}$ for $m_{\rm HPS}=275$ GeV. These are the first constraints on the scalar-Higgs mixing angle $\theta$ from a dedicated experimental search in this mass range., Comment: This paper is dedicated to the memory of Salvatore Davide Porzio. This is the journal accepted version with only minor presentational changes compared to preprint
Published: 2022
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82. Constraints on Sub-GeV Dark Matter--Electron Scattering from the CDEX-10 Experiment

Author: Zhang, Z. Y., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., Agartioglu, M., An, H. P., Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., Saraswat, K., Sharma, V., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yeh, C. H., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: We present improved germanium-based constraints on sub-GeV dark matter via dark matter--electron ($\chi$-$e$) scattering using the 205.4 kg$\cdot$day dataset from the CDEX-10 experiment. Using a novel calculation technique, we attain predicted $\chi$-$e$ scattering spectra observable in high-purity germanium detectors. In the heavy mediator scenario, our results achieve 3 orders of magnitude of improvement for $m_{\chi}$ larger than 80 MeV/c$^2$ compared to previous germanium-based $\chi$-$e$ results. We also present the most stringent $\chi$-$e$ cross-section limit to date among experiments using solid-state detectors for $m_{\chi}$ larger than 90 MeV/c$^2$ with heavy mediators and $m_{\chi}$ larger than 100 MeV/c$^2$ with electric dipole coupling. The result proves the feasibility and demonstrates the vast potential of a new $\chi$-$e$ detection method with high-purity germanium detectors in ultralow radioactive background., Comment: 6 pages, 3 figures. Version updated to match PRL version
Published: 2022
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83. Artificial intelligence in heart failure and transplant

Author: Sarnaik, Kunaal, primary and Tang, W. H. Wilson, additional
Published: 2024
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84. List of contributors

Author: Ahn, Joseph C., primary, Anand, Shankara, additional, Arnaout, O., additional, Bandyopadhyay, Anuja, additional, Bartholomew, Erin, additional, Bates, David W., additional, Bender, Sarah M.L., additional, Bhullar, Puneet K., additional, Bhutani, Tina, additional, Boaro, A., additional, Boyer, Edward W., additional, Brown, Ethan D.L., additional, Carreiro, Stephanie, additional, Chahla, Jorge, additional, Chandran, Viji Pulikkel, additional, Cheng, Ching-Yu, additional, Cheung, Carol Y., additional, Choudhary, Anirudh, additional, Choudhury, Avishek, additional, Chung, Mimi, additional, Ciurtin, Coziana, additional, Comfere, Nneka I., additional, Corriveau-Lecavalier, Nick, additional, Côté, Mélina, additional, del Alamo, Diego, additional, Dias, Roger D., additional, Dönnes, Pierre, additional, Duong, Dat, additional, Ebnali, Mahdi, additional, El Sherbini, Adham, additional, ElZarrad, M. Khair, additional, Fakhouri, Tala H., additional, Fakhoury, Marc, additional, Fein, Joshua A., additional, Fischer, Uwe M., additional, Glicksberg, Benjamin S., additional, Goldstein, Cathy, additional, Gonem, Sherif, additional, Green, Darren V.S., additional, Gupta, Raghav, additional, Hakimi, Marwa, additional, Halamka, John D., additional, Han, Christina S., additional, Hannah-Shmouni, Fady, additional, Harrer, Stefan, additional, Hazime, Ali Amer, additional, Howard, Michael A., additional, Hui, Herbert Y.H., additional, Ildardashty, Alexander, additional, J.F. Shaikh, Hashim, additional, Jeliazkov, Jeliazko R., additional, Jones, David T., additional, Juhn, Young J., additional, Jury, Elizabeth C., additional, Kandaswamy, Swaminathan, additional, Kang, Yanna, additional, Kann, Benjamin H., additional, Kaplin, Scott, additional, Karpiak, Joel, additional, Kassir, Elias, additional, Kaur, Harsimran, additional, Khan, Sohil, additional, Khatib, Reem, additional, Kherabi, Yousra, additional, Knake, Lindsey A., additional, Krittanawong, Chayakrit, additional, Kuhn, Veronica C., additional, Kunze, Kyle, additional, Lamarche, Benoît, additional, Laplante, Simon, additional, Lehmann, Lisa Soleymani, additional, Li, Dawei, additional, Liao, Wilson, additional, Likitlersuang, Jirapat, additional, Liu, Qi, additional, Madani, Amin, additional, Malik, Momin M., additional, Mann, Matthias, additional, Masood, Sameer, additional, Mathur, Piyush, additional, McManus, Sean, additional, Menard, Jeffrey, additional, Mivalt, Filip, additional, Murphree, Dennis, additional, Myers, Thomas G., additional, Narayan, Sanjiv M., additional, Natarajan, Vivek, additional, Pandav, Krunal, additional, Parwani, Anil V., additional, Pedraza Bermeo, Adriana Marcela, additional, Peiffer-Smadja, Nathan, additional, Peng, Junjie, additional, Peng, Lily, additional, Peters, Margot S., additional, Petrick, Nicholas, additional, Polce, Evan, additional, Poojari, Pooja Gopal, additional, Price, W. Nicholson, additional, Raghavan, Lavanya, additional, Rajan, Asha K., additional, Ran, An Ran, additional, Rangu, Sowmith, additional, Rashid, Muhammed, additional, Reddy, Charitha D., additional, Rider, Nicholas L., additional, Rigatti, Marc, additional, Rivers, Michael, additional, Robinson, George, additional, Rogers, Albert J., additional, Rogerson, Colin M., additional, Ryu, Euijung, additional, Sahiner, Berkman, additional, Sarnaik, Kunaal, additional, Shafi, Saba, additional, Shah, Vijay H., additional, Shapovalov, Maxim V., additional, Sharma, Samin K, additional, Shekhar, Skand, additional, Shin, Harold, additional, Shouval, Roni, additional, Smith, Kenneth, additional, Sokumbi, Olayemi, additional, Solomon, Benjamin D., additional, Somani, Sulaiman S., additional, Sternke, Matt C., additional, Strauss, Maximillian T., additional, Syrowatka, Ania, additional, Tang, W. H. Wilson, additional, Teven, Chad M., additional, Tewari, Ashutosh Kumar, additional, Thunga, Girish, additional, Urena, Estefania, additional, Verma, Ashish, additional, Vietas, Jay, additional, Waikel, Rebekah L., additional, Wi, Chung-Il, additional, Winter, Meredith C., additional, Wong, Melissa S., additional, Wong, Tien Yin, additional, Wu, Chao-Ping, additional, Yeroushalmi, Samuel, additional, Zenati, Marco A., additional, Zeng, Wen-Feng, additional, and Zheng, Yingfeng, additional
Published: 2024
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85. Interaction of a priori Anatomic Knowledge with Self-Supervised Contrastive Learning in Cardiac Magnetic Resonance Imaging

Author: Nakashima, Makiya, Jang, Inyeop, Basnet, Ramesh, Benovoy, Mitchel, Tang, W. H. Wilson, Nguyen, Christopher, Kwon, Deborah, Hwang, Tae Hyun, and Chen, David
Subjects: Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract: Training deep learning models on cardiac magnetic resonance imaging (CMR) can be a challenge due to the small amount of expert generated labels and inherent complexity of data source. Self-supervised contrastive learning (SSCL) has recently been shown to boost performance in several medical imaging tasks. However, it is unclear how much the pre-trained representation reflects the primary organ of interest compared to spurious surrounding tissue. In this work, we evaluate the optimal method of incorporating prior knowledge of anatomy into a SSCL training paradigm. Specifically, we evaluate using a segmentation network to explicitly local the heart in CMR images, followed by SSCL pretraining in multiple diagnostic tasks. We find that using a priori knowledge of anatomy can greatly improve the downstream diagnostic performance. Furthermore, SSCL pre-training with in-domain data generally improved downstream performance and more human-like saliency compared to end-to-end training and ImageNet pre-trained networks. However, introducing anatomic knowledge to pre-training generally does not have significant impact., Comment: Under review at Machine Learning in Healthcare
Published: 2022

86. Search for Neutrinoless Double-Beta Decay of $^{76}$Ge with a Natural Broad Energy Germanium Detector

Author: CDEX collaboration, Dai, W. H., Ma, H., Yue, Q., She, Z., Kang, K. J., Li, Y. J., Agartioglu, M., An, H. P., Chang, J. P., Chen, Y. H., Cheng, J. P., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, X. Y., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Liu, Z. Z., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., Saraswat, K., Sharma, V., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yang, L. T., Yeh, C. H., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
Subjects: Nuclear Experiment, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: A natural broad energy germanium (BEGe) detector is operated in the China Jinping Underground Laboratory (CJPL) for a feasibility study of building the next generation experiment of the neutrinoless double-beta (0{$\nu\beta\beta$}) decay of $^{76}$Ge. The setup of the prototype facility, characteristics of the BEGe detector, background reduction methods, and data analysis are described in this paper. A background index of 6.4$\times$10$^{-3}$ counts/(keV$\cdot$kg$\cdot$day) is achieved and 1.86 times lower than our previous result of the CDEX-1 detector. No signal is observed with an exposure of 186.4 kg$\cdot$day, thus a limit on the half life of $^{76}$Ge 0$\nu\beta\beta$ decay is set at T$_{1/2}^{0\nu}$ $>$ 5.62$\times$10$^{22}$ yr at 90% C.L.. The limit corresponds to an effective Majorana neutrino mass in the range of 4.6 $\sim$ 10.3 eV, dependent on the nuclear matrix elements., Comment: 10 pages, 15 figures
Published: 2022
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87. AI-assisted Optimization of the ECCE Tracking System at the Electron Ion Collider

Author: Fanelli, C., Papandreou, Z., Suresh, K., Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bernauer, J. C., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Dean, C. T., Demarteau, M., Diehl, S., Doshita, N., Dupre, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P. -h. J., Huang, J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lawrence, D., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, W. B., Li, X., Liang, Y. T., Lim, S., Lin, C. -h., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Marchand, D., Marcisovsky, M., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Oresic, S., Osborn, J. D., O'Shaughnessy, C., Paganis, S., Pate, S. F., Patel, M., Paus, C., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K. F., Roed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zha, W., Zhang, J., Zhang, Y., Zhao, Y. X., Zheng, X., and Zhuang, P.
Subjects: Physics - Instrumentation and Detectors, Computer Science - Machine Learning, High Energy Physics - Experiment, Nuclear Experiment, Physics - Computational Physics
Abstract: The Electron-Ion Collider (EIC) is a cutting-edge accelerator facility that will study the nature of the "glue" that binds the building blocks of the visible matter in the universe. The proposed experiment will be realized at Brookhaven National Laboratory in approximately 10 years from now, with detector design and R&D currently ongoing. Notably, EIC is one of the first large-scale facilities to leverage Artificial Intelligence (AI) already starting from the design and R&D phases. The EIC Comprehensive Chromodynamics Experiment (ECCE) is a consortium that proposed a detector design based on a 1.5T solenoid. The EIC detector proposal review concluded that the ECCE design will serve as the reference design for an EIC detector. Herein we describe a comprehensive optimization of the ECCE tracker using AI. The work required a complex parametrization of the simulated detector system. Our approach dealt with an optimization problem in a multidimensional design space driven by multiple objectives that encode the detector performance, while satisfying several mechanical constraints. We describe our strategy and show results obtained for the ECCE tracking system. The AI-assisted design is agnostic to the simulation framework and can be extended to other sub-detectors or to a system of sub-detectors to further optimize the performance of the EIC detector., Comment: 16 pages, 18 figures, 2 appendices, 3 tables
Published: 2022
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88. Scientific Computing Plan for the ECCE Detector at the Electron Ion Collider

Author: Bernauer, J. C., Dean, C. T., Fanelli, C., Huang, J., Kauder, K., Lawrence, D., Osborn, J. D., Paus, C., Adkins, J. K., Akiba, Y., Albataineh, A., Amaryan, M., Arsene, I. C., Gayoso, C. Ayerbe, Bae, J., Bai, X., Baker, M. D., Bashkanov, M., Bellwied, R., Benmokhtar, F., Berdnikov, V., Bock, F., Boeglin, W., Borysova, M., Brash, E., Brindza, P., Briscoe, W. J., Brooks, M., Bueltmann, S., Bukhari, M. H. S., Bylinkin, A., Capobianco, R., Chang, W. -C., Cheon, Y., Chen, K., Chen, K. -F., Cheng, K. -Y., Chiu, M., Chujo, T., Citron, Z., Cline, E., Cohen, E., Cormier, T., Morales, Y. Corrales, Cotton, C., Crafts, J., Crawford, C., Creekmore, S., Cuevas, C., Cunningham, J., David, G., Demarteau, M., Diehl, S., Doshita, N., Dupré, R., Durham, J. M., Dzhygadlo, R., Ehlers, R., Fassi, L. El, Emmert, A., Ent, R., Fatemi, R., Fegan, S., Finger, M., Finger Jr., M., Frantz, J., Friedman, M., Friscic, I., Gangadharan, D., Gardner, S., Gates, K., Geurts, F., Gilman, R., Glazier, D., Glimos, E., Goto, Y., Grau, N., Greene, S. V., Guo, A. Q., Guo, L., Ha, S. K., Haggerty, J., Hayward, T., He, X., Hen, O., Higinbotham, D. W., Hoballah, M., Horn, T., Hoghmrtsyan, A., Hsu, P. -h. J., Huber, G., Hutson, A., Hwang, K. Y., Hyde, C., Inaba, M., Iwata, T., Jo, H. S., Joo, K., Kalantarians, N., Kalicy, G., Kawade, K., Kay, S. J. D., Kim, A., Kim, B., Kim, C., Kim, M., Kim, Y., Kistenev, E., Klimenko, V., Ko, S. H., Korover, I., Korsch, W., Krintiras, G., Kuhn, S., Kuo, C. -M., Kutz, T., Lajoie, J., Lebedev, S., Lee, H., Lee, J. S. H., Lee, S. W., Lee, Y. -J., Li, W., Li, X., Liang, Y. T., Lim, S., Lin, C. -h., Lin, D. X., Liu, K., Liu, M. X., Livingston, K., Liyanage, N., Llope, W. J., Loizides, C., Long, E., Lu, R. -S., Lu, Z., Lynch, W., Marchand, D., Marcisovsky, M., Markowitz, P., Marukyan, H., McGaughey, P., Mihovilovic, M., Milner, R. G., Milov, A., Miyachi, Y., Mkrtchyan, A., Monaghan, P., Montgomery, R., Morrison, D., Movsisyan, A., Mkrtchyan, H., Camacho, C. Munoz, Murray, M., Nagai, K., Nagle, J., Nakagawa, I., Nattrass, C., Nguyen, D., Niccolai, S., Nouicer, R., Nukazuka, G., Nycz, M., Okorokov, V. A., Orešić, S., O'Shaughnessy, C., Paganis, S., Papandreou, Z, Pate, S. F., Patel, M., Penman, G., Perdekamp, M. G., Perepelitsa, D. V., da Costa, H. Periera, Peters, K., Phelps, W., Piasetzky, E., Pinkenburg, C., Prochazka, I., Protzman, T., Purschke, M. L., Putschke, J., Pybus, J. R., Rajput-Ghoshal, R., Rasson, J., Raue, B., Read, K., Røed, K., Reed, R., Reinhold, J., Renner, E. L., Richards, J., Riedl, C., Rinn, T., Roche, J., Roland, G. M., Ron, G., Rosati, M., Royon, C., Ryu, J., Salur, S., Santiesteban, N., Santos, R., Sarsour, M., Schambach, J., Schmidt, A., Schmidt, N., Schwarz, C., Schwiening, J., Seidl, R., Sickles, A., Simmerling, P., Sirca, S., Sharma, D., Shi, Z., Shibata, T. -A., Shih, C. -W., Shimizu, S., Shrestha, U., Slifer, K., Smith, K., Sokhan, D., Soltz, R., Sondheim, W., Song, J., Strakovsky, I. I., Steinberg, P., Stepanov, P., Stevens, J., Strube, J., Sun, P., Sun, X., Suresh, K., Tadevosyan, V., Tang, W. -C., Araya, S. Tapia, Tarafdar, S., Teodorescu, L., Timmins, A., Tomasek, L., Trotta, N., Trotta, R., Tveter, T. S., Umaka, E., Usman, A., van Hecke, H. W., Van Hulse, C., Velkovska, J., Voutier, E., Wang, P. K., Wang, Q., Wang, Y., Watts, D. P., Wickramaarachchi, N., Weinstein, L., Williams, M., Wong, C. -P., Wood, L., Wood, M. H., Woody, C., Wyslouch, B., Xiao, Z., Yamazaki, Y., Yang, Y., Ye, Z., Yoo, H. D., Yurov, M., Zachariou, N., Zajc, W. A., Zhang, J., Zhang, Y., Zhao, Y. X., Zheng, X., and Zhuang, P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment, Physics - Computational Physics
Abstract: The Electron Ion Collider (EIC) is the next generation of precision QCD facility to be built at Brookhaven National Laboratory in conjunction with Thomas Jefferson National Laboratory. There are a significant number of software and computing challenges that need to be overcome at the EIC. During the EIC detector proposal development period, the ECCE consortium began identifying and addressing these challenges in the process of producing a complete detector proposal based upon detailed detector and physics simulations. In this document, the software and computing efforts to produce this proposal are discussed; furthermore, the computing and software model and resources required for the future of ECCE are described.
Published: 2022
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89. Measurement of neutral current single $\pi^0$ production on argon with the MicroBooNE detector

Author: MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.
Subjects: High Energy Physics - Experiment
Abstract: We report the first measurement of $\pi^0$ production in neutral current (NC) interactions on argon with average neutrino energy of $\lesssim1$~GeV. We use data from the MicroBooNE detector's 85-tonne active volume liquid argon time projection chamber situated in Fermilab's Booster Neutrino Beam and exposed to $5.89\times10^{20}$ protons on target for this measurement. Measurements of NC $\pi^0$ events are reported for two exclusive event topologies without charged pions. Those include a topology with two photons from the decay of the $\pi^0$ and one proton and a topology with two photons and zero protons. Flux-averaged cross-sections for each exclusive topology and for their semi-inclusive combination are extracted (efficiency-correcting for two-plus proton final states), and the results are compared to predictions from the \textsc{genie}, \textsc{neut}, and \textsc{NuWro} neutrino event generators. We measure cross sections of $1.243\pm0.185$ (syst) $\pm0.076$ (stat), $0.444\pm0.098\pm0.047$, and $0.624\pm0.131\pm0.075$ $[10^{-38}\textrm{cm}^2/\textrm{Ar}]$ for the semi-inclusive NC$\pi^0$, exclusive NC$\pi^0$+1p, and exclusive NC$\pi^0$+0p processes, respectively., Comment: 16 pages, 14 figures, 2 tables
Published: 2022

90. Observation of Radon Mitigation in MicroBooNE by a Liquid Argon Filtration System

Author: MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hilgenberg, C., Horton-Smith, G. A., Hourlier, A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Joe, C., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H. B., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., Zhang, C., and Zuckerbrot, M.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The MicroBooNE liquid argon time projection chamber (LArTPC) maintains a high level of liquid argon purity through the use of a filtration system that removes electronegative contaminants in continuously-circulated liquid, recondensed boil off, and externally supplied argon gas. We use the MicroBooNE LArTPC to reconstruct MeV-scale radiological decays. Using this technique we measure the liquid argon filtration system's efficacy at removing radon. This is studied by placing a 500 kBq $^{222}$Rn source upstream of the filters and searching for a time-dependent increase in the number of radiological decays in the LArTPC. In the context of two models for radon mitigation via a liquid argon filtration system, a slowing mechanism and a trapping mechanism, MicroBooNE data supports a radon reduction factor of greater than 99.999% or 97%, respectively. Furthermore, a radiological survey of the filters found that the copper-based filter material was the primary medium that removed the $^{222}$Rn. This is the first observation of radon mitigation in liquid argon with a large-scale copper-based filter and could offer a radon mitigation solution for future large LArTPCs., Comment: 14 pages, 7 figures, accepted by the Journal of Instrumentation
Published: 2022
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91. Publisher Correction: A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

Author: Ferrell, Marc, Wang, Zeneng, Anderson, James T., Li, Xinmin S., Witkowski, Marco, DiDonato, Joseph A., Hilser, James R., Hartiala, Jaana A., Haghikia, Arash, Cajka, Tomas, Fiehn, Oliver, Sangwan, Naseer, Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, Landmesser, Ulf, Tang, W. H. Wilson, Allayee, Hooman, and Hazen, Stanley L.
Published: 2024
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92. Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study.

Author: Wang, Meng, Wang, Zeneng, Lee, Yujin, Lai, Heidi, de Oliveira Otto, Marcia, Lemaitre, Rozenn, Fretts, Amanda, Sotoodehnia, Nona, DiDonato, Joseph, McKnight, Barbara, Tang, W, Psaty, Bruce, Siscovick, David, Hazen, Stanley, Mozaffarian, Dariush, and Budoff, Matthew
Subjects: cardiovascular diseases, microbiome, myocardial infarction, red meat, stroke, trimethylamine N-oxide, Animals, Atherosclerosis, Cardiovascular Diseases, Carnitine, Humans, Meat, Methylamines, Risk Factors
Abstract: BACKGROUND: Effects of animal source foods (ASF) on atherosclerotic cardiovascular disease (ASCVD) and underlying mechanisms remain controversial. We investigated prospective associations of different ASF with incident ASCVD and potential mediation by gut microbiota-generated trimethylamine N-oxide, its L-carnitine-derived intermediates γ-butyrobetaine and crotonobetaine, and traditional ASCVD risk pathways. METHODS: Among 3931 participants from a community-based US cohort aged 65+ years, ASF intakes and trimethylamine N-oxide-related metabolites were measured serially over time. Incident ASCVD (myocardial infarction, fatal coronary heart disease, stroke, other atherosclerotic death) was adjudicated over 12.5 years median follow-up. Cox proportional hazards models with time-varying exposures and covariates examined ASF-ASCVD associations; and additive hazard models, mediation proportions by different risk pathways. RESULTS: After multivariable-adjustment, higher intakes of unprocessed red meat, total meat, and total ASF associated with higher ASCVD risk, with hazard ratios (95% CI) per interquintile range of 1.15 (1.01-1.30), 1.22 (1.07-1.39), and 1.18 (1.03-1.34), respectively. Trimethylamine N-oxide-related metabolites together significantly mediated these associations, with mediation proportions (95% CI) of 10.6% (1.0-114.5), 7.8% (1.0-32.7), and 9.2% (2.2-44.5), respectively. Processed meat intake associated with a nonsignificant trend toward higher ASCVD (1.11 [0.98-1.25]); intakes of fish, poultry, and eggs were not significantly associated. Among other risk pathways, blood glucose, insulin, and C-reactive protein, but not blood pressure or blood cholesterol, each significantly mediated the total meat-ASCVD association. CONCLUSIONS: In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.
Published: 2022

93. Sarcopenia and frailty in patients undergoing transcatheter aortic valve replacement

Author: Persits, Ian, Mirzai, Saeid, Sarnaik, Kunaal S., Volk, Maximilian C., Yun, James, Harb, Serge, Puri, Rishi, Kapadia, Samir, Krishnaswamy, Amar, Chen, Po-Hao, Reed, Grant, and Tang, W. H. Wilson
Published: 2024
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94. Platelet Membrane Biomimetic Manganese Carbonate Nanoparticles Promote Breast Cancer Stem Cell Clearance for Sensitized Radiotherapy

Author: Jiang Y, Liao X, Tang W, Huang C, Pan Y, and Ning S
Subjects: cancer stem cells clearance, radiosensitization, platelet membrane, sonodynamic therapy, manganese carbonate nanoparticles., Medicine (General), R5-920
Abstract: Yi Jiang,1,&ast; Xiaoming Liao,1,&ast; Wei Tang,2 Chunyu Huang,3 You Pan,2 Shipeng Ning2 1Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, 530000, People’s Republic of China; 2Department of Breast Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, People’s Republic of China; 3Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, 430072, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shipeng Ning, Email nspdoctor@sr.gxmu.edu.cnIntroduction: The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy of radiotherapy (RT). Efficient elimination of potential CSCs is crucial for enhancing the effectiveness of RT.Methods: In this study, we developed a biomimetic hybrid nano-system (PMC) composed of MnCO3 as the inner core and platelet membrane (PM) as the outer shell. By exploiting the specific recognition properties of membrane surface proteins, PMC enables precise targeting of CSCs. Sonodynamic therapy (SDT) was employed using manganese carbonate nanoparticles (MnCO3 NPs), which generate abundant reactive oxygen species (ROS) upon ultrasound (US) irradiation, thereby impairing CSC self-renewal capacity and eradicating CSCs. Subsequent RT effectively eliminates common tumor cells.Results: Both in vitro cell experiments and in vivo animal studies demonstrate that SDT mediated by PMC synergistically enhances RT to selectively combat CSCs while inhibiting tumor growth without noticeable side effects.Discussion: Our findings offer novel insights for enhancing the efficacy and safety profiles of RT.Keywords: cancer stem cells clearance, radiosensitization, platelet membrane, sonodynamic therapy, manganese carbonate nanoparticles
Published: 2024

95. Molecular Characteristics and Antimicrobial Susceptibility Profiles of blaKPC-Producing Escherichia Coli Isolated from a Teaching Hospital in Shanghai, China

Author: Cao S, Jiang X, Suo J, Lu Y, Ju M, Zeng Q, Zheng Q, Zhang Z, and Tang W
Subjects: escherichia coli, blakpc, carbapenemases, plasmids typing, Infectious and parasitic diseases, RC109-216
Abstract: Shuaijun Cao,1,&ast; Xiaoying Jiang,2,&ast; Jinshan Suo,3 Yanyan Lu,2 Mohan Ju,2 Qixiang Zeng,1 Qingru Zheng,1 Zuoyan Zhang,1 Wenqi Tang1 1Department of Critical Care Medicine, Shanghai Sixth People’s Hospital, Shanghai, People’s Republic of China; 2Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 3Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zuoyan Zhang; Wenqi Tang, Department of Critical Care Medicine, Shanghai Sixth People’s Hospital, No. 600 Yishan Road, Shanghai, 200000, People’s Republic of China, Tel +86 021-24058331, Email 18930177049@189.cn; zhang_zy1969@163.comIntroduction: Carbapenem-Resistant Enterobacteriaceae (CRE) has posed a significant threat to humans.The aim of this study was to investigate the molecular characteristics of blaKPC-producing Escherichia coli in a university-affiliated tertiary hospital.Methods: Polymerase chain reaction (PCR) and BLAST+ software were used to detect the prevalence of blaKPC in E. coli and Klebsiella pneumoniae. Whole-genome sequencing was performed for the blaKPC-harboring clinical E. coli isolates. Antimicrobial resistance genes, MLSTs, KPC-carrying plasmid typing and genetic environment of blaKPC were analyzed. A maximum likelihood core single nucleotide polymorphism (SNP)-based phylogeny tree was constructed to determine the evolutionary relationships within this ST131 collection. Conjugation experiments were performed to determine the mobilization of blaKPC. The minimal inhibitory concentrations of the common antimicrobial agents were determined using the broth microdilution method.Results: The prevalence of blaKPC in 424 clinical E. coli isolates and 1636 E. coli strains from GenBank database were 2.2% (45/2060) whereas the detection rate of blaKPC in K. pneumoniae from the GenBank database was 29.8% (415/1394). The blaKPC-harboring conjugants exhibited resistance to multiple β-lactams, except for cefepime-zidebactam and ceftazidime-avibactam. All blaKPC-carring E. coli isolates were susceptible to tigecycline and polymyxin B. ST131 was the dominant sequence type of blaKPC-carring E. coli, accounting for 40.0% (18/45). Most of the blaKPC-producing ST131 E. coli (89.5%,17/19) belonged to clade C ST131 lineage. Genetic environment analysis revealed that 57.8% (26/45) of blaKPC gene was linked to Tn 4401-associated structure ISKpn6-blaKPC-ISKpn7. IncN was the most common plasmid type in KPC-producing E. coli whereas IncFII was the dominant plasmid type in KPC-producing K. pneumoniae.Conclusion: The detection rate of blaKPC was lower in E. coli compared with K. pneumoniae. The dominant sequence and plasmid types of blaKPC-harboring isolates differed between E. coli and K. pneumoniae. Further studies about the role of the defense system in acquisition of KPC-plasmids in E. coli will be performed to provide new insights into the low prevalence of blaKPC.Keywords: Escherichia coli, blaKPC, carbapenemases, plasmids typing
Published: 2024

96. Cosmic ray muon clustering for the MicroBooNE liquid argon time projection chamber using sMask-RCNN

Author: MicroBooNE collaboration, Abratenko, P., An, R., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Church, E., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hilgenberg, C., Horton-Smith, G. A., Hourlier, A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Moon, J., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Murphy, M., Naples, D., Navrer-Agasson, A., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Terao, K., Thorpe, C., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Van De Pontseele, W., Viren, B., Weber, M., Wei, H., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, F. J., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.
Subjects: High Energy Physics - Experiment
Abstract: In this article, we describe a modified implementation of Mask Region-based Convolutional Neural Networks (Mask-RCNN) for cosmic ray muon clustering in a liquid argon TPC and applied to MicroBooNE neutrino data. Our implementation of this network, called sMask-RCNN, uses sparse submanifold convolutions to increase processing speed on sparse datasets, and is compared to the original dense version in several metrics. The networks are trained to use wire readout images from the MicroBooNE liquid argon time projection chamber as input and produce individually labeled particle interactions within the image. These outputs are identified as either cosmic ray muon or electron neutrino interactions. We find that sMask-RCNN has an average pixel clustering efficiency of 85.9% compared to the dense network's average pixel clustering efficiency of 89.1%. We demonstrate the ability of sMask-RCNN used in conjunction with MicroBooNE's state-of-the-art Wire-Cell cosmic tagger to veto events containing only cosmic ray muons. The addition of sMask-RCNN to the Wire-Cell cosmic tagger removes 70% of the remaining cosmic ray muon background events at the same electron neutrino event signal efficiency. This event veto can provide 99.7% rejection of cosmic ray-only background events while maintaining an electron neutrino event-level signal efficiency of 80.1%. In addition to cosmic ray muon identification, sMask-RCNN could be used to extract features and identify different particle interaction types in other 3D-tracking detectors., Comment: 30 pages, 21 figures
Published: 2022

97. Constraints on sub-GeV dark matter boosted by cosmic rays from the CDEX-10 experiment at the China Jinping Underground Laboratory

Author: Xu, R., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., Agartioglu, M., An, H. P., Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, X. Y., Guo, Q. J., He, L., He, S. M., Hu, J. W., Huang, H. X., Huang, T. C., Jia, H. T., Jiang, X., Li, H. B., Li, J. M., Li, J., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y., Liu, Y. D., Liu, Y. Y., Liu, Z. Z., Ma, H., Mao, Y. C., Nie, Q. Y., Ning, J. H., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., Saraswat, K., Sharma, V., She, Z., Singh, M. K., Sun, T. X., Tang, C. J., Tang, W. Y., Tian, Y., Wang, G. F., Wang, L., Wang, Q., Wang, Y., Wang, Y. X., Wong, H. T., Wu, S. Y., Wu, Y. C., Xing, H. Y., Xu, Y., Xue, T., Yan, Y. L., Yeh, C. H., Yi, N., Yu, C. X., Yu, H. J., Yue, J. F., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, Z. H., Zhang, Z. Y., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: We present new constraints on light dark matter boosted by cosmic rays (CRDM) using the 205.4 kg day data of the CDEX-10 experiment conducted at the China Jinping Underground Laboratory. The Monte Carlo simulation package CJPL\_ESS was employed to evaluate the Earth shielding effect. Several key factors have been introduced and discussed in our CRDM analysis, including the contributions from heavier CR nuclei than proton and helium, the inhomogeneity of CR distribution, and the impact of the form factor in the Earth attenuation calculation. Our result excludes the dark matter--nucleon elastic scattering cross-section region from $1.7\times 10^{-30}$ to $10^{-26}~\rm cm^2$ for dark matter of 10 keV$/c^2$ to 1 GeV$/c^2$., Comment: 9 pages, 7 figures. Version updated to match PRD version
Published: 2022
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98. Prevalence of ATTR-CA and high-risk features to guide testing in patients referred for TAVR

Author: Abadie, Bryan, Ali, Adel Hajj, Martyn, Trejeeve, Higgins, Andrew, Krishnaswamy, Amar, Reed, Grant, Puri, Rishi, Yun, James, Cremer, Paul, Hanna, Mazen, Tang, W. H. Wilson, Kapadia, Samir, and Jaber, Wael
Published: 2023
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99. Study on the Relationship Between the Number of Adverse Drug Reactions of Essential Drugs and Visits: Based on Vector Autoregressive Model

Author: Tang W, Chen H, Zhang Z, Wu G, and Lin Y
Subjects: essential medicines, adverse drug reactions, vector autoregressive model, time-series analysis, Public aspects of medicine, RA1-1270
Abstract: Wan Tang,1,2 Hongdou Chen,1,2 Zixin Zhang,1,2 Gang Wu,1,2 Yanquan Lin1– 3 1Pharmacy, Suqian Hospital of Nanjing Drum-Tower Hospital Group, Suqian, People’s Republic of China; 2Pharmacy, Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, People’s Republic of China; 3Pharmacy, Xuzhou Medical University, Xuzhou, People’s Republic of ChinaCorrespondence: Hongdou Chen, Email chenhongdou2000@aliyun.comObjective: To analyse the relationship between the adverse drug reactions (ADRs) of essential drugs and visits, based on the recorded annual increase in ADRs associated with essential medicines in China, to provide a reliable theoretical basis for further analysis and optimization of the safety of essential drugs.Methods: The data of adverse reactions of essential drugs in China from 2011 to 2020, time series analysis was conducted, and vector autoregressive (VAR) model was established. The relationship between the number of ADRs and visits was explored empirically through Granger causality test, impulse response function and variance decomposition.Results: There was a long-term cointegration relationship and one-way causality between the number of visits and ADRs caused by essential medicines. In the initial stage, the ADR response to the number of visits increased sharply, but with an increase in the number of lag periods, the impact remained basically stable, even showing a slight decreasing trend.Conclusion: The number of visits impacts ADRs caused by essential medicines, but this impact remains basically stable after reaching a certain level.Keywords: essential medicines, adverse drug reactions, vector autoregressive model, time-series analysis
Published: 2023

100. Unsuspected Mitochondrial Myopathy Unveiled by Invasive Cardiopulmonary Exercise Testing

Author: Martens, Pieter, Van Iterson, Erik H., Tang, W. H. Wilson, and Finet, J. Emanuel
Published: 2024
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