80 results on '"Tamrat Assefa"'
Search Results
52. Impact of coronavirus of 2019 on the delivery of pharmacy services to patients with cancer: An international survey of oncology pharmacy practitioners
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Tan Wen Chieh, Grace Chazan, Larry W Buie, Nora Alkhudair, Shaun O'Connor, Gail Rowan, D. McKavanagh, Estela Moreno Martinez, Irene Weru, Alexandre Chan, Marliese Alexander, Nick Duncan, Kofi Boamah Mensah, Thomas McFarlane, David L. DeRemer, Manit Sae-Teaw, Pinkie Chambers, Tiene Bauters, Majed Alshamrani, Tamrat Assefa Tadesse, Jennifer Jupp, Kellie J. Weddle, Deogratias Katabalo, and Hisanaga Nomura
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Oncology ,medicine.medical_specialty ,Telepharmacy ,business.industry ,Service delivery framework ,MEDLINE ,Pharmacy ,Medical Oncology ,Pharmacists ,Mental health ,Coronavirus ,Intensive care ,Internal medicine ,Pharmaceutical Services ,Neoplasms ,Surveys and Questionnaires ,Workforce ,medicine ,Humans ,Pharmacology (medical) ,business ,Coronavirus Infections ,Personal protective equipment - Abstract
Introduction The coronavirus of 2019 pandemic has necessitated vast and rapid changes in the way oncology pharmacy services are delivered around the world. Methods/aims An international survey of oncology pharmacists and technicians was conducted via the International Society of Oncology Pharmacy Practitioners and collaborating global pharmacy organisations to determine the impact that the coronavirus of 2019 has had on pharmacy service delivery, pharmacy practitioners and oncology practice. Results The survey received 862 responses from 40 different countries from September to October 2020. The majority of respondents were pharmacists ( n = 841, 97.6%), with 24% involved in the direct care of patients with the coronavirus of 2019. Of the survey participants, 55% increased their time working remotely, with remote activities including dispensing, patient assessment/follow-up and attending multi-disciplinary rounds. Respondents reported a 72% increase in the use of technology to perform remote patient interaction activities and that participation in educational meetings and quality improvement projects was reduced by 68% and 44%, respectively. Workforce impacts included altered working hours (50%), cancelled leave (48%) and forced leave/furloughing (30%). During the pandemic, respondents reported reduced access to intensive care (19%) and anti-cancer (15%) medications. In addition, 39% of respondents reported reduced access to personal protective equipment, including N95 masks for chemotherapy compounding. Almost half of respondents (49%) reported that cancer treatments were delayed or intervals were altered for patients being treated with curative intent. A third of practitioners (30%) believed that patient outcomes would be adversely impacted by changes to pharmacy services. Sixty-five percent of respondents reported impacts on their mental health, with 12% utilising support services. Conclusion The coronavirus of 2019 pandemic has altered the way oncology pharmacy services are delivered. These results demonstrate the adaptability of the oncology pharmacy profession and highlight the importance of formal evaluation of the varied practice models to determine the evidence-based practices that enhance pharmacy services and, thus, should be reinstated as soon as practical and reasonable.
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- 2022
53. Health-related quality of life and its predictors among people living with epilepsy at Dessie Referral Hospital, Amhara, Ethiopia: A cross-sectional study
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Stotaw, Alebachew Sisay, primary, Kumar, Prem, additional, Beyene, Dessale Abate, additional, Tadesse, Tamrat Assefa, additional, and Abiye, Alfoalem Araba, additional
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- 2022
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54. Incidence of thromboembolism and thromboprophylaxis in medical patients admitted to specialized hospital in Ethiopia using Padua prediction score
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Asmamaw, Mulugeta, primary, Hungnaw, Wubet, additional, Motbainor, Achenef, additional, Kedir, Hanan Muzeyin, additional, and Tadesse, Tamrat Assefa, additional
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- 2022
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55. Tuberculosis treatment outcome among patients treated in public primary healthcare facility, Addis Ababa, Ethiopia: a retrospective study
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Tadesse Jorgi, Tamrat Assefa, and Atalay Mulu Fentie
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medicine.medical_specialty ,Tuberculosis ,Odds ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Adjusted odds ratio ,030212 general & internal medicine ,Family history ,Health policy ,0303 health sciences ,030306 microbiology ,business.industry ,Research ,Public health ,lcsh:Public aspects of medicine ,Public Health, Environmental and Occupational Health ,Health services research ,Retrospective cohort study ,Treatment outcomes ,lcsh:RA1-1270 ,Odds ratio ,medicine.disease ,Multinomial logistic regression ,business ,Primary health care level - Abstract
Background Despite the availability of effective drugs, tuberculosis remains a major public health problem that predominantly affects low- and middle-income countries. This study aimed to assess tuberculosis treatment outcomes among patients treated at one of the primary health care levels in Addis Ababa, Ethiopia. Methods An institutional-based retrospective cross-sectional study was conducted at a tuberculosis clinic in public primary healthcare facility. The study populations were all patients with tuberculosis who had been completed their treatment course in the center from July 2014 to July 2018. After getting Ethical clearance and permission from the health center, trained data collectors working in the center were recruited. The collected data were checked for completeness every day by the principal investigators. Data were edited, cleaned, and analyzed using SPSS version 25. Descriptive statistics were used to summarize the data while multinomial logistic regression was employed to explore associations among variables of interest, and p Results A total of 352 patients with tuberculosis were included for the study with a median age of 25 years which ranged from 1 to79 year. Most (36.4%) participants were in the age group of 15 to 24 years. The majority (38.8%) of patients had extrapulmonary tuberculosis, 11.9% of them were HIV positive and only two had family history of tuberculosis. Regarding treatment outcome, 238(67.6%) completed the treatment, 95(27%) cured and the rest were unsuccessful treatment outcomes 19(5.4%) either died, defaulted or treatment failed. The odds ratio for cured in relation to unsuccessful treatment outcome was found to be significantly higher in HIV negative patients (AOR = 6.1; 95%CI 2.1–13.9) compared with those patients tested positive for HIV. While patients with smear-positive pulmonary tuberculosis (AOR = 10.5, 95% CI 5.36–16.31) were significantly associated with the odds of having complete treatment cure as compared to patients with extrapulmonary tuberculosis. Similarly being HIV positive and extrapulmonary tuberculosis were predicting factors for unsuccessful treatment compared with their counterparts. Conclusions The finding of the present study showed that successful tuberculosis treatment outcome was found to be optimal.
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- 2020
56. Adherence to Benzathine Penicillin G Secondary Prophylaxis and Its Determinants in Patients with Rheumatic Heart Disease at a Cardiac Center of an Ethiopian Tertiary Care Teaching Hospital
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Kajela Kibirat Mekonen, Alfoalem Araba Abiye, Malede Berihun Yismaw, and Tamrat Assefa Tadesse
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medicine.medical_specialty ,Heart disease ,Medicine (miscellaneous) ,Logistic regression ,Tertiary care ,Teaching hospital ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Benzathine penicillin g ,050602 political science & public administration ,Medicine ,In patient ,030212 general & internal medicine ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Original Research ,business.industry ,Health Policy ,05 social sciences ,Secondary prophylaxis ,Acute rheumatic fever ,rheumatic heart disease ,medicine.disease ,0506 political science ,Tikur Anbessa Specialized Hospital ,adherence rate ,Patient Preference and Adherence ,benzathine penicillin G ,Ethiopia ,business ,Social Sciences (miscellaneous) - Abstract
Kajela Kibirat Mekonen, Malede Berihun Yismaw, Alfoalem Araba Abiye, Tamrat Assefa Tadesse Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Tamrat Assefa Tadesse P.O. Box: 9086, Addis Ababa, EthiopiaEmail tamrat.assefa@aau.edu.etPurpose: Benzathine penicillin G (BPG) monthly administration is the most effective method for secondary prophylaxis against acute rheumatic fever (ARF). BPG’s efficacy largely depends on adherence to treatment. This study was aimed at assessing adherence to BPG prophylaxis and its determinants among adult patients with rheumatic heart disease.Patients and Methods: An institutional cross-sectional study design was used. One hundred and forty-five patients receiving monthly BPG at the Adult Cardiac Clinic of Tikur Anbessa Specialized Hospital (TASH) were interviewed. Their 1-year BPG prophylaxis administration record was also reviewed. The rate of adherence to BPG injection was determined by calculating the percentage of the administered drug from the total expected doses. Data were entered and analyzed using Statistical Package for Social Sciences (SPSS) software version 25. Both descriptive and logistic regression analyses were computed to describe different variables and assess factors associated with adherence, respectively. A p-value < 0.05 was used to declare association.Results: Among a total of 145 study participants involved, the majority (76.6%) of them had been receiving BPG for the last 10 years. The average adherence rate to monthly BPG injection was 80.60% with a range of 0% to 100%. However, only 101 (69.7%) of participants were taking ≥ 80% of their prescribed monthly BPG prophylaxis doses. Study participants with informal education 1.10 (0.023– 46.96) and secondary school education 0.89 (0.10– 8.11) were more and less likely to adhere to BPG injection, respectively, when compared with those who attended higher education programs. The regression analysis showed patients who were not admitted to the hospital (AOR: 26.22; CI: 2.55– 269.70; p=0.006) and once admitted patients (AOR: 50.08; CI: 2.87– 873.77; p=0.007) were more likely to adhere to their BPG injections than those admitted twice or more. The study participants who waited until the next appointment were also less adherent (AOR: 0.02; CI: 0.00– 0.13; p=0.000) than those who went a few days later for receiving the missed/late dose.Conclusion: The adherence rate to BPG injection among RHD patients was found to be high (80.60%). Patients’ admission status and their action on missed and/or late doses were found to be important determinants of adherence in this study.Keywords: rheumatic heart disease, benzathine penicillin G, adherence rate, Tikur Anbessa Specialized Hospital, Ethiopia
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- 2020
57. Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia
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Kumsa, Seefu Megarsa, primary, Tadesse, Tamrat Assefa, additional, and Woldu, Minyahil Alebachew, additional
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- 2021
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58. Impact of coronavirus of 2019 on the delivery of pharmacy services to patients with cancer: An international survey of oncology pharmacy practitioners
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Chazan, Grace, primary, Jupp, Jennifer, additional, Bauters, Tiene, additional, Duncan, Nick, additional, Weddle, Kellie Jones, additional, Nomura, Hisanaga, additional, O’Connor, Shaun, additional, Chan, Alexandre, additional, Alkhudair, Nora, additional, Alshamrani, Majed, additional, Buie, Larry W, additional, Chambers, Pinkie, additional, Chieh, Tan Wen, additional, DeRemer, David L, additional, Duvivier, France, additional, Katabalo, Deogratias, additional, McFarlane, Thomas, additional, Mckavanagh, Daniel, additional, Mensah, Kofi, additional, Martinez, Estela Moreno, additional, Rowan, Gail, additional, Sae-teaw, Manit, additional, Tadesse, Tamrat Assefa, additional, Weru, Irene, additional, and Alexander, Marliese, additional
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- 2021
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59. Incidence of thromboembolism and thromboprophylaxis in medical patients admitted to specialized hospital in Ethiopia using Padua prediction score
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Mulugeta Asmamaw, Wubet Hungnaw, Achenef Motbainor, Hanan Muzeyin Kedir, and Tamrat Assefa Tadesse
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General Medicine - Abstract
Introduction: Venous thromboembolism is a major cause of mortality and morbidity among hospitalized patients and thromboprophylaxis is one of the key strategies to reduce such events. We aimed to assess venous thromboembolism risk using Padua prediction score, thromboprophylaxis practice, and outcomes in hospitalized medical patients at Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia. Methods: A cross-sectional study was conducted among 219 patients admitted to Tibebe Ghion Specialized Hospital from 1 December 2018 to 31 May 2019. Data were collected from patients’ medical records using a pre-tested data abstraction format to collect patients’ clinical information and venous thromboembolism risk using the Padua prediction score. We used Statistical Package for the Social Sciences version 26 for data analysis. Descriptive statistics was used to summarize the findings, and binary logistic regression analysis was used to assess association between the variables of interest. Results: Reduced mobility, recent trauma and/or surgery, heart and/or respiratory failure, and active cancer were the frequently identified venous thromboembolism risk factors. Based on Padua prediction score, 48.4% of patients were at high risk of developing venous thromboembolism. The venous thromboembolism prophylaxis was given only for 55 (25.1%) patients and 15 of them were at low risk of developing venous thromboembolism (Conclusion: Nearly half of the patients were at risk of developing venous thromboembolism. Underutilization of thromboprophylaxis and inappropriate use of prophylaxis were commonly seen in Tibebe Ghion Specialized Hospital.
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- 2021
60. COVID-19 Vaccine Hesitancy and its Reasons in Addis Ababa, Ethiopia: A Cross-Sectional Study.
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Tadesse, Tamrat Assefa, Antheneh, Ashenafi, Teklu, Ashenafi, Teshome, Asres, Alemayehu, Bemnet, Belayneh, Alemu, Abate, Dessale, and Abiye, Alfoalem Araba
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VACCINE hesitancy , *COVID-19 vaccines , *VACCINATION complications , *MEDICAL personnel , *COVID-19 , *HAND injuries - Abstract
BACKGROUND: Coronavirus disease (COVID-19) vaccine hesitancy becomes the major bottleneck to the global healthcare system in minimizing the spread of the virus. This study aimed at assessing COVID-19 vaccine hesitancy and its reasons among residents of Addis Ababa, Ethiopia. METHODS: A community-based cross-sectional survey was conducted between May 16 to 29, 2021 in purposively selected four districts of Addis Ababa, Ethiopia. A structured questionnaire was developed and then designed on Google Forms platforms to collect data from study participants after obtaining a verbal consent form. A total of 422 study participants were included in the survey. Data were entered into Microsoft Excel and then exported to the Statistical Package for the Social Sciences (SPSS) version 25 for analysis. RESULTS: Face masks and alcohol hand rub/sanitizer are used by 50.7 and 24.9% of respondents when required. COVID-19 was thought to have been generated by humans by a substantial percentage of study participants (38.2%). About half (50.7%) and 24.9% of respondents use face masks and alcohol hand rub/sanitizer always when it is required, respectively. A large number of study participants (38.2%) believed that origin of COVID-19 is man-made. Overall, 242 (57.4%) of study participants reported COVID-19 vaccine hesitancy. Fear of vaccine side effects (49.6%) was the most common reason for hesitancy. Doubt about its effectiveness (33.9%), not having enough information about the COVID-19 vaccine, preferring another way of protection, and unreliable of the vaccine (due to its short development period) were also the most frequently mentioned reasons for not receiving the COVID-19 vaccine. CONCLUSIONS: COVID-19 vaccine hesitancy rate was high in Addis Ababa, Ethiopia during the study period. Fear of side effects, doubts about its effectiveness, and not having enough information about the COVID-19 vaccine were major reasons for hesitancy. Continuous awareness creation to the community on the importance of vaccination is warranted by health professionals and healthcare cadres. [ABSTRACT FROM AUTHOR]
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- 2022
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61. Publisher Correction: Comparison of anticoagulation control and outcomes between usual medical care and pharmacist-led anticoagulation service in ambulatory patients taking warfarin at tertiary hospital in Ethiopia: a quasi-experimental study.
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Tadesse, Tamrat Assefa, Gebremedhin, Amha, Yadeta, Dejuma, Chelkeba, Legese, and Fenta, Teferi Gedif
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AUTHOR-reader relationships ,MEDICAL care ,WARFARIN ,APOLOGIZING ,ANTICOAGULANTS - Abstract
This document is a correction notice for an article titled "Comparison of anticoagulation control and outcomes between usual medical care and pharmacist-led anticoagulation service in ambulatory patients taking warfarin at tertiary hospital in Ethiopia: a quasi-experimental study." The correction addresses an error in table 3 of the original article, where the heading stated "i=210" instead of the correct information "N=210." The publisher apologizes for any inconvenience caused. The article was authored by Tamrat Assefa Tadesse, Amha Gebremedhin, Dejuma Yadeta, Legese Chelkeba, and Teferi Gedif Fenta. Springer Nature, the publisher, remains neutral regarding jurisdictional claims and institutional affiliations. [Extracted from the article]
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- 2024
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62. Treatment Approaches of Multiple Myeloma
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Tamrat Assefa Tadesse, Atalay Mulu Fentie, and Minyahil Alebachew Woldu
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Oncology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,business ,medicine.disease ,Multiple myeloma ,030215 immunology - Abstract
Multiple Myeloma (MM) is the most common malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. Clinical investigation of MM requires the evaluation of bone marrow for plasma cell infiltration, and detection and quantification of monoclonal protein in the serum or urine, and evidence for end-organ damage (i.e., hypercalcemia, renal insufficiency, anemia, or bone lesions). The overall goal of treatment of MM is to improve survival. The treatment landscape and clinical outcome of MM have changed in the last two decades, with an improved median survival of 8–10 years. Management of MM involves induction, consolidation, and maintenance therapy. Currently, Autologous stem cell transplant (ASCT) is considered as the standard care of treatment for newly diagnosed fit MM patients. Multiple combinations of proteasome inhibitors (PIs) and immunomodulatory drugs (IMIDs) such as Thalidomide, lenalidomide, and pomalidomide have been under evaluation in ASCT-eligible and ineligible settings, and studies are still ongoing. For patients with ASCT-eligible newly diagnosed MM, induction therapy with triple drugs should contain an IMiD, a PI, and a corticosteroid, usually lenalidomide-bortezomib-dexamethasone. For ASCT-ineligible patients on lenalidomide with dexamethasone (Rd), with addition of bortezomib or daratumumab can be considered.
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- 2021
63. Management practice, and quality of life and its associated factors among ambulatory psoriatic patients attending Dermatological Center in Addis Ababa, Ethiopia
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Seifu Megersa Kumsa, Minyahil Alebachew Woldu, and Tamrat Assefa Tadesse
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medicine.medical_specialty ,Quality of life (healthcare) ,business.industry ,Family medicine ,Ambulatory ,medicine ,Center (algebra and category theory) ,business - Abstract
Background: Psoriasis is a chronic inflammatory disease characterized by keratinocyte hyperproliferation and aberrant differentiation with great negative impact on patients’ quality of life (QoL). This study aimed at assessing management practice, and quality of life (QoL) and its associated factors among ambulatory psoriatic patients visiting All Africa Leprosy, Tuberculosis and Rehabilitation Training (ALERT) Center in Addis Ababa, Ethiopia.Materials and methods: A cross sectional study was conducted among 207 patients with psoriasis attending the dermatology clinic of ALERT Center in Addis Ababa, Ethiopia. Data were collected using structured questionnaire and patients’ chart review. Dermatology Life Quality Index (DLQI) was used to measure patients’ QoL. Data was analyzed entered and analyzed using Statistical Package for Social Sciences (SPSS®) version 25. Descriptive statistics like frequency, percent, mean and standard deviation were used to summarize patients’ characteristics while binary logistic regression was utilized to identify predictors of quality of life. Results: Among 207 study participants, 122(58.9%) were females. The mean age of the study population was 37.92(SD=14.86) years (ranging from 16 to 68 years). The mean age at which diagnosis of psoriasis made was 32.0(SD=13.7) years ranging from 10 to 62 years. The duration of the disease in 112(54.1%) patients were more than or equal to 5 years. Among study participants, the majority of them, 145(70.0%) had plaque psoriasis followed by sebopsoriasis, 24(11.6%). The majority of plaque psoriasis (80%) cases were managed by topical corticosteroids with or without salicylic acid or coal tar and only 21(14.5%) treated by methotrexate alone. Other forms of psoriasis were treated by only topical corticosteroids with or without salicylic acid. The mean DLQI was 6.25 corresponding to a moderate effect. Symptoms and feelings were the most affected domains of QoL. Factors associated with poor QoL were female gender [AOR=0.17 (95%CI: 0.06, 0.48)], low, above average and high family income ([AOR=0.12(95% CI: 0.02, 0.56)], [AOR=0.06(95% CI:0.01, 0.32)], and [AOR=0.03 (95% CI: 0.01, 0.22)]) respectively and primary education level [AOR=0.14 (95% CI: 0.03, 0.64)] while being on systemic therapy [AOR=4.26 (CI: 1.18, 15.35)] was predictor of better QoL.Conclusion: Topical corticosteroids were the mainstay of psoriasis treatment in our study. The mean DLQI was 6.25, corresponding to a moderate effect on QoL. Study participants with female gender, primary education level, and low, above average, and high monthly family income were considered to have worse QoL whereas receiving systemic therapy significantly associated with better QoL. Hence, future interventions targeting improving QoL and widening treatment options for psoriasis deemed to be necessary.
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- 2021
64. Outcome of Acute Deep Venous Thrombosis Using Standard Treatment versus Thrombolytics: A Literature Review
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Minyahil Alebachew Woldu, Pacifique Ndayishimiye, Alemseged Beyene, Tamrat Assefa, and Abdella Birhan
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medicine.medical_specialty ,Deep vein ,medicine.medical_treatment ,Population ,MEDLINE ,Review Article ,030204 cardiovascular system & hematology ,lcsh:RC254-282 ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Thrombolytic drug ,law ,medicine ,030212 general & internal medicine ,Intensive care medicine ,education ,Transplantation ,education.field_of_study ,business.industry ,Standard treatment ,Hematology ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Thrombosis ,Thrombolytic ,Therapy ,Deep venous thrombosis ,Pulmonary embolism ,medicine.anatomical_structure ,Oncology ,business - Abstract
Deep vein thrombosis (DVT) is a major health problem affectinga significant portion of population. Primary complications are Pulmonary Embolism (PE) in the short term and Post-Thrombotic Syndrome (PTS) in the long term. Thrombolytic drugs act by activating plasminogen which in turn forms the enzyme plasmin. Plasmin consequently degrades blood clots by breaking down the fibrin molecules which make up the clots help to degrade the already formed clot. They can be used using different route of administration, doses and durations. The purpose of this systematic review was to assess the outcome of thrombolytic therapy in terms of the efficacy, safety and effectiveness of the medicines. Electronic searches of databases (MEDLINE and Google Scholar) were queried for articles written in English since 2000 GC. A total of 760 results were obtained using the search keys, and after excluding duplicates, 275 articles were selected. Finally, 9 randomized controlled trials (RCTs) which met the language of publication, study design and exclusion criteria were included in this systematic review. The data were obtained from nine trials (6 countries), providing a study-level data of 1309 participants. Almost all studies revealed that thrombolytic treatment was effective in the management of acute DVT. In most of the studies, the rate of rethrombosis was lower in case of thrombolytic than standard management. Hence, addition of thrombolytic results in persistence and increases the clinical benefits. Thrombolytic therapy was very effective in reversing closed veins, in boosting the patency rate,whilereflux was higher in patients treated with anticoagulants. Thrombolytic offers potential advantages over the standard treatment of DVT by reducing the proportion of patients with chronic disabling leg symptoms (such as PTS) by triple in the longer term. However, the incident of major bleeding was higher in patients receiving thrombolytics than anticoagulants.
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- 2019
65. sj-docx-1-opp-10.1177_10781552211048892 - Supplemental material for Impact of coronavirus of 2019 on the delivery of pharmacy services to patients with cancer: An international survey of oncology pharmacy practitioners
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Chazan, Grace, Jupp, Jennifer, Bauters, Tiene, Duncan, Nick, Weddle, Kellie Jones, Nomura, Hisanaga, O’Connor, Shaun, Chan, Alexandre, Alkhudair, Nora, Alshamrani, Majed, Buie, Larry W, Chambers, Pinkie, Chieh, Tan Wen, DeRemer, David L, Duvivier, France, Katabalo, Deogratias, McFarlane, Thomas, Mckavanagh, Daniel, Mensah, Kofi, Martinez, Estela Moreno, Rowan, Gail, Sae-teaw, Manit, Tadesse, Tamrat Assefa, Weru, Irene, and Alexander, Marliese
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FOS: Clinical medicine ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,111299 Oncology and Carcinogenesis not elsewhere classified - Abstract
Supplemental material, sj-docx-1-opp-10.1177_10781552211048892 for Impact of coronavirus of 2019 on the delivery of pharmacy services to patients with cancer: An international survey of oncology pharmacy practitioners by Grace Chazan, Jennifer Jupp, Tiene Bauters, Nick Duncan, Kellie Jones Weddle, Hisanaga Nomura, Shaun O’Connor, Alexandre Chan, Nora Alkhudair, Majed Alshamrani, Larry W Buie, Pinkie Chambers, Tan Wen Chieh, David L DeRemer, France Duvivier, Deogratias Katabalo, Thomas McFarlane, Daniel Mckavanagh, Kofi Mensah, Estela Moreno Martinez, Gail Rowan, Manit Sae-teaw, Tamrat Assefa Tadesse, Irene Weru and Marliese Alexander in Journal of Oncology Pharmacy Practice
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- 2021
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66. Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia
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Tamrat Assefa Tadesse, Minyahil Alebachew Woldu, and Seefu Megarsa Kumsa
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Male ,Cross-sectional study ,Petroleum Products ,Logistic regression ,Systemic therapy ,Steroid Therapy ,Geographical Locations ,Quality of life ,Medicine and Health Sciences ,Child ,Materials ,Multidisciplinary ,Pharmaceutics ,Drugs ,Dermatology Life Quality Index ,Middle Aged ,Petroleum ,Physical Sciences ,Ambulatory ,Educational Status ,Population study ,Medicine ,Female ,Organic Materials ,Research Article ,Adult ,medicine.medical_specialty ,Adolescent ,Corticosteroid Therapy ,Science ,Immunology ,Materials Science ,Dermatology ,Autoimmune Diseases ,Young Adult ,Drug Therapy ,Psoriasis ,Internal medicine ,medicine ,Humans ,Pharmacology ,business.industry ,Biology and Life Sciences ,medicine.disease ,Health Care ,Cross-Sectional Studies ,Methotrexate ,People and Places ,Africa ,Quality of Life ,Tar ,Clinical Immunology ,Ethiopia ,Clinical Medicine ,business - Abstract
BackgroundPsoriasis is a chronic inflammatory disease characterized by keratinocyte hyperproliferation and aberrant differentiation with great negative impact on patients’ quality of life (QoL). This study aimed at assessing factors influencing management practice, and QoL and its associated factors among ambulatory psoriatic patients visiting All Africa Leprosy, Tuberculosis and Rehabilitation Training (ALERT) Center in Addis Ababa, Ethiopia.Materials and methodsA cross sectional study was conducted in 207 patients with psoriasis attending the dermatology clinic of ALERT Center in Addis Ababa, Ethiopia. Data were collected using structured questionnaire and patients’ chart review. Dermatology Life Quality Index (DLQI) was used to measure patients’ QoL. Patients’ characteristics were summarized using descriptive statistics and predictors of QoL were identified by binary logistic regression.ResultsAmong 207 study participants, 122 (58.9%) were females. The mean age of the study population was 37.92 (SD = 14.86) years (ranging from 16 to 68 years). The mean age at which diagnosis of psoriasis made was 32 (SD = 13.7) years ranging from 10 to 62 years. The duration of the disease in 112 (54.1%) patients were more than or equal to 5 years. Majority of study participants 145 (70.0%) had plaque psoriasis followed by sebopsoriasis, 24 (11.6%). The majority of plaque psoriasis (80%) cases were managed by topical corticosteroids with or without salicylic acid or coal tar and only 21 (14.5%) treated by methotrexate alone. The mean DLQI was 6.25 corresponding to a moderate effect. Symptoms and feelings were the most affected domains of QoL. Factors associated with poor QoL were female [AOR = 0.17 (95%CI: 0.06, 0.48)], low, above average and high family income ([AOR = 0.12 (95% CI: 0.02, 0.56)], [AOR = 0.06 (95% CI:0.01, 0.32)], and [AOR = 0.03 (95% CI: 0.01, 0.22)]), respectively, and primary education level [AOR = 0.14 (95% CI: 0.03, 0.64)] while being on systemic therapy [AOR = 4.26 (CI: 1.18, 15.35)] was predictor of better QoL. Poor QoL was predominant in females [AOR = 0.17 (95%CI: 0.06, 0.48)], low income [AOR = 0.12 (95% CI: 0.02, 0.56] patients, and patients with primary education level [AOR = 0.14 (95% CI: 0.03, 0.64)]. Patients on systemic therapy [AOR = 4.26 (CI: 1.18, 15.35)] had good QoL.ConclusionOur study identified that topical corticosteroids were the mainstay of psoriasis treatment in the dermatology clinic of ALERT Center in Addis Ababa, Ethiopia. Moderate effect QoL was achieved by study participants based on DLQL score.
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- 2021
67. sj-docx-2-opp-10.1177_10781552211048892 - Supplemental material for Impact of coronavirus of 2019 on the delivery of pharmacy services to patients with cancer: An international survey of oncology pharmacy practitioners
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Chazan, Grace, Jupp, Jennifer, Bauters, Tiene, Duncan, Nick, Weddle, Kellie Jones, Nomura, Hisanaga, O’Connor, Shaun, Chan, Alexandre, Alkhudair, Nora, Alshamrani, Majed, Buie, Larry W, Chambers, Pinkie, Chieh, Tan Wen, DeRemer, David L, Duvivier, France, Katabalo, Deogratias, McFarlane, Thomas, Mckavanagh, Daniel, Mensah, Kofi, Martinez, Estela Moreno, Rowan, Gail, Sae-teaw, Manit, Tadesse, Tamrat Assefa, Weru, Irene, and Alexander, Marliese
- Subjects
FOS: Clinical medicine ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,111299 Oncology and Carcinogenesis not elsewhere classified - Abstract
Supplemental material, sj-docx-2-opp-10.1177_10781552211048892 for Impact of coronavirus of 2019 on the delivery of pharmacy services to patients with cancer: An international survey of oncology pharmacy practitioners by Grace Chazan, Jennifer Jupp, Tiene Bauters, Nick Duncan, Kellie Jones Weddle, Hisanaga Nomura, Shaun O’Connor, Alexandre Chan, Nora Alkhudair, Majed Alshamrani, Larry W Buie, Pinkie Chambers, Tan Wen Chieh, David L DeRemer, France Duvivier, Deogratias Katabalo, Thomas McFarlane, Daniel Mckavanagh, Kofi Mensah, Estela Moreno Martinez, Gail Rowan, Manit Sae-teaw, Tamrat Assefa Tadesse, Irene Weru and Marliese Alexander in Journal of Oncology Pharmacy Practice
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- 2021
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68. Management practice, and quality of life and its associated factors among ambulatory psoriatic patients attending Dermatological Center in Addis Ababa, Ethiopia
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Kumsa, Seifu Megersa, primary, Tadesse, Tamrat Assefa, additional, and Woldu, Minyahil Alebachew, additional
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- 2021
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69. Anticoagulation Control, Outcomes, and Associated Factors in Patients with Atrial Fibrillation Receiving Warfarin at Tertiary Care Hospital in Ethiopia
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Yimer, Nuredin Shiferaw, primary, Abiye, Alfoalem Araba, additional, Hussen, Shemsu Umer, additional, and Tadesse, Tamrat Assefa, additional
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- 2021
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70. Surgical Antimicrobial Prophylaxis and Incidence of Surgical Site Infections at Ethiopian Tertiary-Care Teaching Hospital
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Alfoalem Araba Abiye, Kerebih Alamrew, Tamrat Assefa Tadesse, and Workineh Shibeshi
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medicine.medical_specialty ,business.industry ,General surgery ,Incidence (epidemiology) ,Surgical wound ,St. Paul’s Hospital Millennium Medical College ,surgical site infection ,Antimicrobial ,Tertiary care ,Teaching hospital ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Surgical site ,Surgical antimicrobial prophylaxis ,Medicine ,lcsh:RC109-216 ,030212 general & internal medicine ,Ethiopia ,business ,Surgical site infection ,Original Research - Abstract
Background: Surgical site infections (SSIs) are infections that develop within 30 days after an operation or surveillance of surgical wound infection implementation within 90 days after surgery when an implant is placed. The objective of this study was to assess preoperative and postoperative antimicrobial use in St. Paul’s Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia. Methods: A hospital-based cross-sectional study was undertaken in surgery wards of SPHMMC for 4 months by reviewing 413 patients’ charts. All patients 13 years and older who were admitted and underwent different types of surgical procedures were included in the study. Epi info 7 was used for data entry, and then data were exported to Statistical Package for Social Sciences (SPSS) version 20.0 software for analysis. Descriptive analyses were computed and rate of SSI was calculated in this study. Moreover, bivariate analysis was done to examine the relationship between the outcome variable and predictor variables with a value of P Results: Out of 413 patients, 152 (36.8%) were operated for general surgery, and the remaining were for other types of surgeries. Most of the patients, 196 (79.7%), were managed by a single surgical antibiotic agent, followed by 2 agents (20.3%) for surgical prophylaxis indication. Surgical site infections occurred in 46 (11.1%) patients before discharge from the hospital. In those patients who need treatment for SSIs, almost half of them (49.5%) received combination therapy of ceftriaxone and metronidazole. Emergency surgical cases were 2.647 times more likely to develop SSIs than the elective surgical cases (adjusted odds ratio [AOR] = 2.647; 95% confidence interval [CI] = 1.406-4.983; P = .003). Patients who did not receive antibiotic prophylaxis were 2.572 times more likely to develop SSIs compared to those who received antibiotic prophylaxis (AOR = 2.572; 95% CI = 1.02-6.485; P = .045). Clean-contaminated and contaminated types of wound were a protective factor against SSI in our study. Conclusions: This study indicated that most of the patients (72.1%) received surgical antimicrobial prophylaxis. The overall incidence rate of SSIs was 11.1% in the studied hospital. Ceftriaxone was the most commonly used drug. Being not receiving prophylaxis, wound class, and surgery types were significantly associated with the development of SSI.
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- 2019
71. Adherence to Benzathine Penicillin G Secondary Prophylaxis and Its Determinants in Patients with Rheumatic Heart Disease at a Cardiac Center of an Ethiopian Tertiary Care Teaching Hospital
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Mekonen, Kajela Kibirat, primary, Yismaw, Malede Berihun, additional, Abiye, Alfoalem Araba, additional, and Tadesse, Tamrat Assefa, additional
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- 2020
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72. Quality of anticoagulation management with warfarin among outpatients in a tertiary hospital in Addis Ababa, Ethiopia: a retrospective cross-sectional study
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Bekele Alemayehu, Teferi Gedif Fenta, and Tamrat Assefa
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Male ,Inr ,Pediatrics ,medicine.medical_specialty ,Cross-sectional study ,medicine.drug_class ,Anticoagulation management ,030204 cardiovascular system & hematology ,Ambulatory Care Facilities ,Health administration ,Tertiary Care Centers ,03 medical and health sciences ,0302 clinical medicine ,Tikur Anbessa specialized hospital ,INR self-monitoring ,Outpatients ,Humans ,Medicine ,Outpatient clinic ,Thrombolytic Therapy ,heterocyclic compounds ,International Normalized Ratio ,030212 general & internal medicine ,cardiovascular diseases ,Time in therapeutic range ,Hospitals, Teaching ,Aged ,Retrospective Studies ,business.industry ,Health Policy ,lcsh:Public aspects of medicine ,Anticoagulant ,Warfarin ,Anticoagulants ,Retrospective cohort study ,lcsh:RA1-1270 ,Middle Aged ,Cross-Sectional Studies ,Female ,Ethiopia ,business ,Research Article ,medicine.drug - Abstract
Background Warfarin is the most widely used anticoagulant in the world. The difficulty of managing warfarin contributes to great potential for patient harm, both from excessive anticoagulation and insufficient anticoagulation. This study assessed the International Normalized Ratio (INR) control outcome measures and warfarin dose adjustment practices at cardiology and hematology outpatient clinics at a teaching hospital in Addis Ababa, Ethiopia. Methods The study was based on a cross - sectional study design involving 360 retrospective patients’ chart review among outpatients who received warfarin for its various indications. Results The mean frequency of INR monitoring per patient was 62.9 days (17.2–143.7 days). Patients spent 52.2%, 29.0% and 18.8% of the time in sub-therapeutic, therapeutic and supra-therapeutic ranges, respectively. The daily warfarin dose was increased 50.9% and 36.9% and decreased in 52.8% and 60.9% of the time for occurrences of sub-therapeutic and supra-therapeutic INRs to achieve target ranges of 2.0–3.0 and 2.5–3.5, respectively. Conclusion The quality of anticoagulation management with warfarin among outpatients in Tikur Anbessa Specialized Hospital was sub-optimal. This was reflected by low Time in Therapeutic Range (TTR), longer than recommended INR monitoring frequency, and minimal actions taken to adjust warfarin dose after occurrences of non-therapeutic INRs.
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- 2017
73. The Position of Clinical Pharmacists in Delivering Advanced Pharmacy Practice Education and Services
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Demisew Berihun Haile, Minyahil Alebachew Woldu, Belete Ayalneh Worku, Tamrat Assefa Tadesse, Alemseged Beyene Berha, Melaku Tileku Tamiru, and Mamo Fayissa Senbeta
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Clinical pharmacy ,Medical education ,Position (obstetrics) ,business.industry ,Nuclear pharmacy ,Medicine ,Pharmacy practice ,business - Published
- 2016
74. COMPARISON OF AMPHOTERICIN B AND ITS COMBINATION WITH FLUCY TOSINE IN THE MANAGEMENT OF CRYPTOCOCCAL MENINGITIS: A REVIEW.
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Kumsa, Seifu Megersa, Yismaw, Malede Berihun, Woldu, Minyahil Alebachew, and Tadesse, Tamrat Assefa
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- 2021
75. MOESM1 of Pattern of antibiotics use, incidence and predictors of surgical site infections in a Tertiary Care Teaching Hospital
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Ezaedin Halawi, Tamrat Assefa, and Sadikalmahdi Hussen
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Additional file 1. Factors associated with SSIs occurrence among surgical patients in TASH (N = 131). It is additional material which describes bivariate logistic regression model showing seven variables were associated with the occurrence of SSIs at p
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- 2018
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76. Surgical Antimicrobial Prophylaxis and Incidence of Surgical Site Infections at Ethiopian Tertiary-Care Teaching Hospital
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Alamrew, Kerebih, primary, Tadesse, Tamrat Assefa, additional, Abiye, Alfoalem Araba, additional, and Shibeshi, Workineh, additional
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- 2019
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77. The Position of Clinical Pharmacists in Delivering Advanced Pharmacy Practice Education and Services
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Woldu, Minyahil Alebachew, primary, Berha, Alemseged Beyene, additional, Haile, Demisew Berihun, additional, Tadesse, Tamrat Assefa, additional, Worku, Belete Ayalneh, additional, Senbeta, Mamo Fayissa, additional, and Tamiru, Melaku Tileku, additional
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- 2016
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78. Overall HIV-1 prevalence in pregnant women over-estimates HIV-1 in the predominantly rural population of Afar Region
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Tamrat, Assefa, Gail, Davey, Nicole, Dukers, Dawit, Wolday, Alemayehu, Worku, Tsehaynesh, Messele, Belete, Tegbaru, Wendelien, Dorigo, and Eduard J, Sanders
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Adult ,Adolescent ,AIDS Serodiagnosis ,Reproducibility of Results ,HIV Infections ,Prenatal Care ,Rural Health ,Ambulatory Care Facilities ,Cross-Sectional Studies ,HIV Seroprevalence ,Pregnancy ,HIV Seropositivity ,HIV-1 ,Prevalence ,Humans ,Female ,Ethiopia ,Sentinel Surveillance - Abstract
The appropriateness of sentinel sero-surveillance based upon ante-natal clinic (ANC) attendees to estimate HIV-1 prevalence in the general population has been questioned. In Ethiopia, where the population is heterogeneous and where economic and practical barriers to ANC attendance exist, problems of extrapolation may be exacerbated. We planned an unlinked anonymous sero-survey which included data on basic population characteristics to investigate whether sero-surveillance data from ANCs in Afar Region might be taken to represent the situation among the general population of the Region. 371 pregnant women attending Dubti Hospital and Assayta Health Centre were tested for HIV-1 (using a single ELISA test) and active syphilis (RPR test). Socio-demographic characteristics were collected for each woman. Of the women tested, 278 (75%) were 28 years of age or younger. Two hundred eighty (76%) were urban residents and 237 (64%) described themselves as being of Amhara ethnicity. Overall, 73 (19.7%) were HIV-1 positive, but prevalence was three times higher among the 237 women of Amhara ethnicity compared to the 112 of Afar ethnicity (24.9% vs 8.0%, p0.001), and almost three times higher for urban compared to rural residents (23.2% vs 8.8%, p0.001). Positive RPR results were strongly associated with HIV-1 infection (OR 3.37, 95% CI 1.47-7.71). According to the Demographic and Health Survey (DHS) 2000, only 4.5% of the population of Afar Region is of Amhara ethnicity, and 7.8% urban residents. We have demonstrated that basing ANC sero-surveillance in urban areas of Afar Region over-samples urban residents of Amhara ethnicity and yields a major over-estimation of overall HIV-1 prevalence for the Region. Reliable estimation of HIV-1 prevalence in Afar Region will require more flexible strategies that permit sampling of rural Afar residents.
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- 2004
79. Khat and alcohol use and risky sex behaviour among in-school and out-of-school youth in Ethiopia
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Frehiwot Berhane, Reta Ayele, Tewodros Gebremichael, Derege Kebede, Fikre Enquselassie, Wuleta Lemma, Yigeremu Abebe, Atalay Alem, Getnet Mitike, and Tamrat Assefa
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Alcohol Drinking ,Population ,Catha ,Social Environment ,Odds ,Interviews as Topic ,Risk-Taking ,Unsafe Sex ,Khat ,Epidemiology ,medicine ,Humans ,Psychiatry ,education ,Students ,Probability ,education.field_of_study ,biology ,business.industry ,lcsh:Public aspects of medicine ,Public health ,Public Health, Environmental and Occupational Health ,Age Factors ,Coitus ,Social environment ,lcsh:RA1-1270 ,biology.organism_classification ,Adolescent Behavior ,Central Nervous System Stimulants ,Female ,Ethiopia ,Biostatistics ,business ,Demography ,Research Article - Abstract
Background Khat (an evergreen plant with amphetamine-like properties) and alcohol are widely consumed among the youth of Ethiopia. However, their relationship to risky sexual behaviour is not well described. This study was conducted to describe the magnitude of risky sexual behaviour (unprotected sex and early initiation of sexual activity) and its association with Khat and alcohol consumption in Ethiopian youths. Methods A probabilistic national sample of 20,434 in-school and out-of-school youths aged between 15 and 24 years of age was selected and interviewed regarding their sexual behavior and substance use. Results Over 20% of out-of-school youth had unprotected sex during the 12-month period prior to interview compared to 1.4% of in-school youth. Daily Khat intake was also associated with unprotected sex: adjusted OR (95% CI) = 2.26 (1.92, 2.67). There was a significant and linear association between alcohol intake and unprotected sex, with those using alcohol daily having a three fold increased odds compared to those not using it: adj. OR (95% CI) = 3.05 (2.38, 3.91). Use of substances other than Khat was not associated with unprotected sex, but was associated with initiation of sexual activity: adj. OR (95% CI) = 2.54 (1.84, 3.51). Conclusion A substantial proportion of out-of-school youth engage in risky sex. The use of Khat and alcohol and other substances is significantly and independently associated with risky sexual behaviour among Ethiopian youths.
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- 2005
80. Impact of coronavirus of 2019 on the delivery of pharmacy services to patients with cancer: An international survey of oncology pharmacy practitioners.
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Chazan G, Jupp J, Bauters T, Duncan N, Weddle KJ, Nomura H, O'Connor S, Chan A, Alkhudair N, Alshamrani M, Buie LW, Chambers P, Chieh TW, DeRemer DL, Duvivier F, Katabalo D, McFarlane T, Mckavanagh D, Mensah K, Martinez EM, Rowan G, Sae-Teaw M, Tadesse TA, Weru I, and Alexander M
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- Humans, Medical Oncology, Pharmacists, Surveys and Questionnaires, Coronavirus, Pharmaceutical Services, Neoplasms drug therapy, Coronavirus Infections, Pharmacy
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Introduction: The coronavirus of 2019 pandemic has necessitated vast and rapid changes in the way oncology pharmacy services are delivered around the world., Methods/aims: An international survey of oncology pharmacists and technicians was conducted via the International Society of Oncology Pharmacy Practitioners and collaborating global pharmacy organisations to determine the impact that the coronavirus of 2019 has had on pharmacy service delivery, pharmacy practitioners and oncology practice., Results: The survey received 862 responses from 40 different countries from September to October 2020. The majority of respondents were pharmacists ( n = 841, 97.6%), with 24% involved in the direct care of patients with the coronavirus of 2019. Of the survey participants, 55% increased their time working remotely, with remote activities including dispensing, patient assessment/follow-up and attending multi-disciplinary rounds. Respondents reported a 72% increase in the use of technology to perform remote patient interaction activities and that participation in educational meetings and quality improvement projects was reduced by 68% and 44%, respectively. Workforce impacts included altered working hours (50%), cancelled leave (48%) and forced leave/furloughing (30%). During the pandemic, respondents reported reduced access to intensive care (19%) and anti-cancer (15%) medications. In addition, 39% of respondents reported reduced access to personal protective equipment, including N95 masks for chemotherapy compounding. Almost half of respondents (49%) reported that cancer treatments were delayed or intervals were altered for patients being treated with curative intent. A third of practitioners (30%) believed that patient outcomes would be adversely impacted by changes to pharmacy services. Sixty-five percent of respondents reported impacts on their mental health, with 12% utilising support services., Conclusion: The coronavirus of 2019 pandemic has altered the way oncology pharmacy services are delivered. These results demonstrate the adaptability of the oncology pharmacy profession and highlight the importance of formal evaluation of the varied practice models to determine the evidence-based practices that enhance pharmacy services and, thus, should be reinstated as soon as practical and reasonable.
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- 2022
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