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Syed Mahmood, Muhammad Taher, Uttam Kumar Mandal Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Pahang Darul Makmur, Malaysia Abstract: Raloxifene hydrochloride, a highly effective drug for the treatment of invasive breast cancer and osteoporosis in post-menopausal women, shows poor oral bioavailability of 2%. The aim of this study was to develop, statistically optimize, and characterize raloxifene hydrochloride-loaded transfersomes for transdermal delivery, in order to overcome the poor bioavailability issue with the drug. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipon® 90G, sodium deoxycholate, and sonication time, each at three levels, were selected as independent variables, while entrapment efficiency, vesicle size, and transdermal flux were identified as dependent variables. The formulation was characterized by surface morphology and shape, particle size, and zeta potential. Ex vivo transdermal flux was determined using a Hanson diffusion cell assembly, with rat skin as a barrier medium. Transfersomes from the optimized formulation were found to have spherical, unilamellar structures, with a ­homogeneous distribution and low polydispersity index (0.08). They had a particle size of 134±9 nM, with an entrapment efficiency of 91.00%±4.90%, and transdermal flux of 6.5±1.1 µg/cm2/hour. Raloxifene hydrochloride-loaded transfersomes proved significantly superior in terms of amount of drug permeated and deposited in the skin, with enhancement ratios of 6.25±1.50 and 9.25±2.40, respectively, when compared with drug-loaded conventional liposomes, and an ethanolic phosphate buffer saline. Differential scanning calorimetry study revealed a greater change in skin structure, compared with a control sample, during the ex vivo drug diffusion study. Further, confocal laser scanning microscopy proved an enhanced permeation of coumarin-6-loaded transfersomes, to a depth of approximately160 µM, as compared with rigid liposomes. These ex vivo findings proved that a raloxifene hydrochloride-loaded transfersome formulation could be a superior alternative to oral delivery of the drug. Keywords: transfersomes, raloxifene hydrochloride, RSM, Box-Behnken, transdermal flux

Detection and monitoring land use/land cover (LULC) changes using historical multi-temporal remote sensing data is greatly important for providing an effective and robust assessment of the human-induced impacts on the environmental conditions. It is extremely recommended for LULC studies related to evaluating the sustainability of changing areas over time. The agricultural sector in Egypt is one of the crucial pillars of the national economy. The amount of traditional agricultural land (Old Lands) in the Nile Delta had a significant decline over the past few decades due to urban encroachment. Consequently, several land reclamation initiatives and policies have been adopted by the Egyptian government to expand agricultural land in desert areas (New Lands) adjacent to both fringes of the Nile delta. Tiba district is one of those newly reclaimed areas located in the western Nile Delta of Egypt with a total area of 125 km2. The primary objective of this article was to identify, monitor and quantify historical LULC changes in Tiba district using historical multi-temporal Landsat imageries for six different dates acquired from 1988 to 2018. The temporal and historical changes that occurred were identified using supervised maximum likelihood classification (MLC) approach. Three major LULC classes were distinguished and mapped: (1) Agricultural land; (2) barren land; and (3) urban land. In 1988, Tiba district was 100% barren land; however, during the 1990s, the governmental reclamation projects have led to significant changes in LULC. The produced LULC maps from performing the MLC demonstrated that Tiba district had experienced significant agricultural land expansion from 0% in 1988 to occupy 84% in 2018, whilst, barren land area has decreased from 100% in 1988 to occupy only 7% in 2018. This reflects the successful governmental initiatives for agricultural expansion in desert areas located in the western Nile Delta of Egypt.

Egypt has one of the largest and fastest growing populations in the world. However, nearly 96% of the total land area is uninhabited desert and 96% of the population is concentrated around the River Nile valley and the Delta. This unbalanced distribution and dramatically rising population have caused severe socio-economic problems. In this research, 24 land use/land cover (LULC) maps from 1992 to 2015 were used to monitor LULC changes in the Nile Delta and quantify the rates and types of LULC transitions. The results show that 74,600 hectares of fertile agricultural land in the Nile Delta (Old Lands) was lost to urban expansion over the 24 year period at an average rate of 3108 ha year−1, whilst 206,100 hectares of bare land was converted to agricultural land (New Lands) at an average rate of 8588 ha year−1. A Cellular Automata-Markov (CA-Markov) integrated model was used to simulate future alternative LULC change scenarios. Under a Business as Usual scenario, 87,000 hectares of land transitioned from agricultural land to urban areas by 2030, posing a threat to the agricultural sector sustainability and food security in Egypt. Three alternative future scenarios were developed to promote urban development elsewhere, hence, with potential to preserve the fertile soils of the Nile Delta. A scenario which permitted urban expansion into the desert only preserved the largest amount of agricultural land in the Nile Delta. However, a scenario that encouraged urban expansion into the desert and adjacent to areas of existing high population density resulted in almost the same area of agricultural land being preserved. The alternative future scenarios are valuable for supporting policy development and planning decisions in Egypt and demonstrating that continued urban development is possible while minimising the threats to environmental sustainability and national food security.

This research was conducted to study the effect of partial replacing of three different types of cement (ordinary Portland cement, high-slag cement, sulphate resistance cement) with Rice Straw Ash (RSA) on the properties of produced cement pastes. Further, the study focused on incinerations and milling method, physical and chemical properties and pozzolanic activity of RSA. The effect of using RSA on water/cement ratio of the standard consistency paste as well as initial and final setting times of cement paste were investigated. The results show that both initial and final setting times increase with increasing the rice straw ash replacement percent.