51. Neurocognitive Function in Children with Primary Hypertension after Initiation of Antihypertensive Therapy
- Author
-
Lande, Marc B, Batisky, Donald L, Kupferman, Juan C, Samuels, Joshua, Hooper, Stephen R, Falkner, Bonita, Waldstein, Shari R, Szilagyi, Peter G, Wang, Hongyue, Staskiewicz, Jennifer, and Adams, Heather R
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Hypertension ,Behavioral and Social Science ,Basic Behavioral and Social Science ,Cardiovascular ,Clinical Research ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Adolescent ,Antihypertensive Agents ,Blood Pressure ,Case-Control Studies ,Child ,Executive Function ,Female ,Humans ,Male ,Neuropsychological Tests ,Prospective Studies ,blood pressure ,neuropsychological testing ,obesity ,treatment ,Human Movement and Sports Sciences ,Paediatrics and Reproductive Medicine ,Pediatrics ,Paediatrics - Abstract
OBJECTIVE:To determine the change in neurocognitive test performance in children with primary hypertension after initiation of antihypertensive therapy. STUDY DESIGN:Subjects with hypertension and normotensive control subjects had neurocognitive testing at baseline and again after 1 year, during which time the subjects with hypertension received antihypertensive therapy. Subjects completed tests of general intelligence, attention, memory, executive function, and processing speed, and parents completed rating scales of executive function. RESULTS:Fifty-five subjects with hypertension and 66 normotensive control subjects underwent both baseline and 1-year assessments. Overall, the blood pressure (BP) of subjects with hypertension improved (24-hour systolic BP load: mean baseline vs 1 year, 58% vs 38%, P
- Published
- 2018