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63 results on '"Sylvie Bradesi"'

51. W1718 Up-Regulation of COX-2 Expression in the Spinal Cord and Dorsal Root Ganglia of Rats Exposed to Chronic Psychological Stress

Author

Lee W. Slice, James A. McRoberts, Emeran A. Mayer, Helena S. Ennes, Sylvie Bradesi, and Hung Pham

Subjects
Dorsum, medicine.medical_specialty, Endocrinology, medicine.anatomical_structure, Hepatology, Downregulation and upregulation, Internal medicine, Gastroenterology, medicine, Psychological stress, Biology, medicine.disease_cause, Spinal cord
Published
2009
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52. Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-Regulation in a Rat Model of Chronic Stress

Author

Camilla I. Svensson, Sylvie Bradesi, Emeran A. Mayer, Charalabos Pothoulakis, Tony L. Yaksh, and Joanne Steinauer

Subjects
Male, medicine.medical_specialty, Pyridines, Central nervous system, Minocycline, p38 Mitogen-Activated Protein Kinases, Article, Stress, Physiological, Internal medicine, Tachykinin receptor 1, Animals, Medicine, Chronic stress, Enzyme Inhibitors, Rats, Wistar, Water Deprivation, Hepatology, Microglia, business.industry, Imidazoles, Gastroenterology, Receptors, Neurokinin-1, Rats, Up-Regulation, Disease Models, Animal, Viscera, IκBα, Spinal Nerves, medicine.anatomical_structure, Endocrinology, Hyperalgesia, Immunology, medicine.symptom, business, Immunostaining, medicine.drug
Abstract

Background & Aims Chronic psychological stress is associated with visceral hyperalgesia and increased expression of spinal NK1 receptors (NK1Rs). We aimed to identify the role of spinal microglia in this process. Methods Male Wistar rats were exposed to water avoidance (WA) or sham stress 1 hour each day for 10 days and given daily injections of minocycline, the p38 inhibitor SB203580, or saline. Phosphorylation levels of the kinase p38 (P-p38), the microglia marker OX42, NK1R, and IκBα were assessed by immunoblotting and/or immunostaining of spinal samples collected at day 11. The visceromotor response to colorectal distention at baseline and following WA were also assayed in rats given injections of minocycline, SB203580, or vehicle. The effects of fractalkine were assessed on the visceromotor response in rats exposed to minocycline or vehicle. Results P-p38 protein levels and immunoreactivity were increased in stressed rats and colocalized with OX42-positive cells and neurons in the dorsal horn. This increase was reversed by minocycline or SB203580 exposure. Stress-induced increased NK1R expression was blocked by minocycline but not SB203580. WA-induced decreased IκBα expression was blocked by minocycline and SB203580. WA-induced hyperalgesia was blocked by minocycline and SB203580 intrathecally. Fractalkine-induced hyperalgesia was blocked by minocycline. Conclusions This is the first demonstration that stress-induced activation of spinal microglia has a key role in visceral hyperalgesia and associated spinal NK1R up-regulation.

Published
2009
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53. Subject Index Vol. 27, Suppl. 1, 2009

Author

Filip Baert, Vincenzo Stanghellini, David S. Rampton, Cesare Cremon, Daniel Poulain, Peter Holzer, Samir Jawhara, Johan D. Söderholm, Susanne K. Sauer, Elena F. Verdu, Jean-Frederic Colombel, G.T. Macfarlane, Roberto De Giorgio, Stephen M. Collins, Thierry Jouault, Miquel Sans, Premsyl Bercik, Ulrike Holzer-Petsche, Lucia Fronzoni, Fernando Cervero, Giovanni Barbara, Glenn T. Furuta, Philippe Marteau, Sylvie Bradesi, R. Willert, Roberto Corinaldesi, C. Botha, Peter W. Reeh, F. Temmerman, Boualem Sendid, Christopher Bass, Annie Standaert-Vitse, Emmanuel Denou, Bruce E. Sands, Qasim Aziz, Mauro Serra, L.E. Macfarlane, Emeran A. Mayer, Markus F. Neurath, Chantal Fradin, Raja Atreya, Robin C. Spiller, Simon Travis, and William J. Sandborn

Subjects
medicine.medical_specialty, Index (economics), business.industry, Gastroenterology, Physical therapy, Medicine, Subject (documents), General Medicine, business
Published
2009
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57. CRF1 receptor mediates acute and sustained visceral hyperalgesia following an acute stressor in maternally separated long evans rats

Author

James A. McRoberts, Ines Schwetz, Sylvie Bradesi, Huping Zhou, Jerry C. Miller, Gordon V. Ohning, Santosh V. Coutinho, Million Mulugeta, and Emeran A. Mayer

Subjects
medicine.medical_specialty, Long evans rats, Endocrinology, Visceral hyperalgesia, Hepatology, business.industry, Internal medicine, Anesthesia, Crf1 receptor, Gastroenterology, medicine, business, Acute stressor
Published
2003
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