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The epithelium-specific ETS transcription factor-1 (ESE-1) plays multiple roles in pathogenesis and normal development of epithelial tissues. NANOG, a key mediator of stem cell self-renewal and pluripotency, is also expressed in various cancers and pluripotent cells. In this study, we investigated how ESE-1 influences NANOG expression and NANOG-induced proliferation in human germ cell-derived embryonic carcinoma NCCIT cells. Endogenous ESE-1 expression in NCCIT cells significantly increased during differentiation, whereas NANOG expression decreased. In addition, NANOG expression was downregulated by exogenous overexpression of ESE-1, and increased by shRNA-mediated knockdown of ESE-1. NANOG transcriptional activity was reduced by dose-dependent ESE-1 overexpression and a putative ESE-1 binding site (EBS) was mapped within conserved region 2. Site-directed mutagenesis of the putative EBS abrogated the repressive effect of ESE-1 on NANOG promoter activity. ESE-1 directly interacted with the putative EBS to regulate transcriptional activity of NANOG. Furthermore, NANOG-induced proliferation and colony formation of NCCIT cells were inhibited by ESE-1 overexpression and stimulated by ESE-1 shRNA-mediated knockdown. Altogether, our results suggest that ESE-1 exerts an anti-proliferative effect on NCCIT cells by acting as a novel transcriptional repressor of NANOG.

Thermal imaging provides information regarding the general condition of the human body and facilitates the diagnosis of various diseases. Heat therapy or thermotherapy can help in the treatment of injuries to the skin tissue. Here, we report a wearable thermal patch with dual functions of continuous skin temperature sensing and thermotherapy for effective self-care treatment. This system consists of a graphene-based capacitive sensor, a graphene thermal pad, and a flexible readout board with a wireless communication module. The wearable sensor continuously monitors the temperature variation over a large area of the skin (3 × 3cm 2 ) with high resolution and sensitivity and performs thermotherapy via the graphene-based heater mounted at the bottom of the device. Animal studies prove that the proposed system can be used to diagnose various diseases. This technology could be useful in the development of convenient and wearable health care devices.

Watermelon yield mainly depends on soil water content controlled by irrigation in a plastic greenhouse. In this study, we investigated the effect of different soil moisture contents affected by irrigation starting point on growth, yield, and physiological responses of small-sized watermelons. Irrigation was initiated at 5 different levels of soil water content as a starting point with soil moisture detecting sensor after 14 days of transplanting, and stopped at 7 ~ 10 days before harvest. These treatments were compared with the conventional periodic irrigation as control. When soil had the lowest moisture content (-50 kPa), the overall shoot growth was retarded, but the root length and root dry weight increased. The photosynthetic parameters (photosynthetic rate, stomatal conductance, and transpiration rate) of watermelon leaves decreased significantly in the lowest soil moisture content (-50 kPa). On the other hand, the photosynthetic rates of watermelon leaves grown with irrigation starting point between -20 and -40 kPa were observed to be higher than those of other treatments. Fruit set rate and marketable fruit yield increased significantly at –30 kPa and –40 kPa. Proline, abscisic acid (ABA), total phenol and citrulline, which are known to contribute to stress tolerance under drought condition, increased as soil water content decreased, particularly, the largest increases were recorded at –50 kPa. From these results, it was found that an appropriate water supply adjusted with an irrigation starting point between -30 and -40 kPa could help to keep favorable soil water content during the cultivation of small-sized watermelons, promoting the marketable fruit production as well as inducing the vigorous plant growth and reproductive development.

Impaired motor function is a common disabling sequela after stroke. It is closely associated with the patient's quality of life and independence. Neuropsychological dysfunctions also frequently occur in stroke patients. In this paper, we evaluate the relationship between the recovery of motor function and neuropsychological functions, including cognition, language, emotion, behavior, personality, and social interaction, to provide appropriate and effective therapy for stroke patients. Motor function, neuropsychological status, social functioning, as well as emotional aspects such as depression and anxiety symptoms, were initially evaluated one month after cerebral infarction onset. The evaluations were repeated three months after the onset. Motor function was assessed with the Modified Barthel Index. The neuropsychological status was evaluated using the Mini-Mental State Examination, Global Deterioration Scale, digit span test, Korean-Boston Naming Test, Vineland Social Maturity Scale, Neuropsychiatric Inventory, Beck's Depression Inventory, and Beck Anxiety Inventory. In the results, the Modified Barthel Index, Mini-Mental State Examination, Global Deterioration Scale, digit span test, and Vineland Social Maturity Scale were significantly different between the two-time points (P < 0.05). Initial Social Maturity Scale Social Age and Social Maturity Scale Social Quotient categories of the Vineland Social Maturity Scale and Mini-Mental State Examination scores were significantly correlated with Modified Barthel Index improvement (P < 0.05). The amount of change in the Social Maturity Scale Social Age and Social Maturity Scale Social Quotient scores was significantly correlated with Modified Barthel Index improvement (P < 0.05). In multiple linear regression analysis, only the initial Social Maturity Scale Social Quotient score and the amount of score change in Social Maturity Scale Social Quotient showed a significant correlation with Modified Barthel Index improvement (P < 0.05). Social function and interaction are important in motor recovery of ischemic stroke patients.

The BophiVum massif in northwestern Myanmar mainly consists of peridotite, mafic intrusive, and mafic volcanic rocks, oceanic sediments, and chromitites. Small chromitite open pits are randomly distributed in the eastern lowland of the massif. In this study, we interpret the origin of the chromitite and suggest exploration guidelines for hidden orebodies, by understanding their random distribution in three-dimensional (3D) space. This is accomplished by inputting the geological survey data into 3D modeling software. Trench and geological surveys were conducted on the selected ridge (detailed study area) that contains chromitite of a certain thickness and predictable extent to analyze the characteristics of orebody distribution. The general characteristics of the chromitite deposits investigated from the field are: (1) they occur as lenticular pods hosted by dunites, (2) they are located close to the harzburgite-dunite boundary, (3) they are not present in all dunites, and (4) the dominant trend of the dunites and chromitites is WNW or NW-trending. These individual field data were integrated by importing them into 3D modeling software and the resulting model showed the characteristics of chromitite distribution in 3D. The results are: (1) composed of six discontinuous chromitite pods, (2) occurring in a WNW or NW-trending arrangement, (3) located at the WNW or NW-trending lenticular dunite boundary, and (4) maximum depth being 30 m from surface. This study provides useful data for exploration of hidden orebodies in the study area and suggests a new method for integrating field data in 3D space.

As the traditional inverters are transforming toward more intelligent inverters with advanced information and communication technologies, the cyber-attack surface has been remarkably expanded. Specifically, securing firmware of smart inverters from cyber-attacks is crucial. This paper provides expanded firmware attack surface targeting smart inverters. Moreover, this paper proposes a security module for transforming a conventional inverter to a firmware security built-in smart inverter by preventing potential malware and unauthorized firmware update attacks as well as fast automated inverter recovery from zero-day attacks. Furthermore, the proposed security module as a client of blockchain is connected to blockchain severs to fully utilize blockchain technologies such as membership service, ledgers, and smart contracts to detect and mitigate the firmware attacks. The proposed security module framework is implemented in an Internet-of-Thing (IoT) device and validated by experiments.

Water scarcity can mean scarcity in availability due to physical shortage, or scarcity in access due to the failure of institutions to ensure a continuously regular supply or due to a lack of adequate infrastructure. Water scarcity will be exacerbated as rapidly growing urban areas place heavy pressure on water resources. To solve these problems, various solutions have been applied, but a fundamental solution has not been applied. Recently, a researched and developed infiltration rainwater drainage (IRD) system is being applied with consideration of its applicability. In this study, features of surface runoff and infiltration according to various flow patterns were analyzed using a three-dimensional CFD (Computational Fluid Dynamics) model for calculating water flow in the IRD system. To estimate the optimal setup, a permeability test and scaled model simulation were performed. The runoff characteristics of the IRD system with respect to rainfall intensity and duration were analyzed with dimensionless variables. With the prototype model, the drainage characteristics of the IRD system were analyzed over time using the hydrological curves. From the simulated results, it was found that the IRD system analyzed in this study was appropriate in the field by comparative analysis with the existing system based on peak runoff, internal storage, and lag time. Therefore, by applying the IRD system in the future, it is expected that the IRD has benefits, such as delayed lag time, surface runoff decrease, and an attenuation of the peak runoff.

Chuncheon, a medium-sized city in South Korea, frequently shows high PM2.5 concentrations despite scarce anthropogenic emission sources. To identify factors increasing PM2.5 concentrations, PM2.5 and its major chemical components were concurrently measured at two different sites, namely, downtown and suburban areas. The average PM2.5 concentrations at the two sites were similar, but the daily and monthly variations in PM2.5 and its components were significantly larger at the suburban site. NH4+ was significantly higher at the suburban site than at the downtown site, whereas organic carbon (OC) showed the opposite trend. Several PM2.5 samples showed an abrupt increase during winter at the suburban site, along with an increase in the amount of OC, NH4+, and K+, and the correlations between water-soluble OC, K+, and NH4+ were considerably strong, implying that local biomass burning in the suburban site was an important source of high PM2.5 episodes. Secondary OC (SOC) concentration was generally lower at the suburban site than at the downtown site, but its contribution to OC increased during winter with an increase in relative humidity, indicating the significance of heterogeneous SOC formation reactions at the suburban site. These results indicate that relevant local measures can be put into place to alleviate the occurrence of high PM2.5 concentration episodes even in medium-sized residential cities where medium-and long-range transport is anticipated to be significant.

Because river flooding and urban inundation due to extreme rainfall cause the severe damages on the infrastructure, it is necessary to develop an accurate prediction technique and to overcome the disasters. In this study, numerical simulation method was applied to predict urban inundation area with appropriate assumptions and hydrological data in the Lower Var valley region in France. The application site is located in the southeast of France and also geometrically complex with several hydraulic structures, such as weir and bridge piers from the mainstream of a river to the Mediterranean Sea. With complex geometrical consideration, numerical modelling of inundation was conducted separately with two steps. Firstly, the whole area of river reach with the urban area was simulated and analyzed. From the results, the smaller urbanized area was specified with consideration of the capacity of inundation. Two-dimensional hydrodynamic model, MIKE 21 FM (flow model) is applicable to simulations of river hydraulics and flood inundation including the urbanized properties. Upstream discharges for the boundary conditions were set up with based on the Gumbel distribution and SCHADEX method. From the numerical simulation, inundation area and river flow variation were analyzed and compared with respect to the upstream discharge scenarios. Furthermore, the effect of computational mesh resolution was analyzed with the urban model. Calculated flooded areas from the simulation results of the whole area model and urbanized models were compared and verified as a newly proposed and applied procedure of inundation analysis in the riverine area.

In this paper, we propose a compact-standard antenna method (C-SAM) for antenna calibration above 1 GHz. The test-site evaluation of the fully-anechoic room (FAR) condition satisfied the free-space conditions. When the C-SAM was compared with conventional antenna calibration methods, the maximum deviation was within ±0.18 dB for the 1–18 GHz frequency range. Unlike the conventional antenna calibration methods, the proposed method is a simple standard antenna method that calculates the antenna factor of the antenna under calibration (AUC) with only one site insertion loss (SIL) measurement of an antenna calibration site that meets free-space conditions. Therefore, the C-SAM is the best candidate for antenna calibration owing to the method’s simplicity and cost-reduction potential.

The effects of turanose on the physicochemical properties of rice flour systems (aqueous suspension, dough, and noodles) were investigated in terms of rheology, microstructure, and water mobility. Inclusion of turanose increased the pasting viscosities of rice flour by maintaining a closely-packed structure at high temperatures that was confirmed by the real-time microscopic measurements during heating. The elevated probability of intergranular interactions by turanose apparently raised both storage (G') and loss (G″) moduli of the rice flour pastes as well as their respective viscosities. NMR spin-spin relaxation times showed two distinct water populations in the turanose-rice flour samples. The Mixolab experiments demonstrated that the rice doughs with higher levels of turanose exhibited greater dough stability as well as higher degrees of starch gelatinization and retrogradation. Furthermore, the extruded rice noodles containing turanose exhibited a higher expansion ratio and a firmer texture that contributed to lowering the cooking loss by 24.5%.

Background/Aims: Sarcopenia has emerged as an important risk factor for nonalcoholic fatty liver disease (NAFLD). Although aging is the main cause of sarcopenia, the longitudinal association between age-related body composition changes and NAFLD development has not been fully investigated. Thus, we evaluated whether age-related increased fat mass or decreased muscle mass is an independent risk factor for incident NAFLD. Methods: We conducted a retrospective cohort study involving 4,398 initially NAFLD-free subjects who underwent routine health examinations during 2004 to 2005 and returned for a follow-up during 2014 to 2015. Their body composition was measured by bioelectrical impedance analysis, and fatty liver was diagnosed by abdominal ultrasonography. Results: At the 10-year follow-up, 591 out of 4,398 participants (13.4%) had developed NAFLD. In men and women, both increased fat mass and decreased appendicular skeletal muscle mass (ASM) with aging were significantly associated with incident NAFLD after adjustment. A subgroup analysis according to the baseline obesity status showed that increased fat mass was significantly associated with incident NAFLD in obese and nonobese subjects. However, decreased ASM was significantly associated with incident NAFLD in nonobese but not in obese subjects. According to ΔASM tertiles (decrease of ASM), the odds ratios for incident NAFLD in nonobese subjects were 1.38 (95% confidence interval [CI], 1.04 to 1.84) for the second tertile and 1.81 (95% CI, 1.34 to 2.45) for the third tertile after adjustment (p=0.001). Conclusions: A progressive increase in fat mass and a loss of ASM with aging were significantly associated with incident NAFLD. This association was more prominent in nonobese subjects. (Gut Liver 2019;13:67-76)

Energy consumers are evolving into energy prosumers that simultaneously perform the role of production and consumption. The activation of energy transaction owing to the increase of energy prosumers affects the stability management of distribution system. Accordingly, the role of the distribution system operator (DSO) for managing the power distribution system is becoming important. In a power distribution system with low demand, if a prosumers trade large amounts of power through peer-to-peer energy transaction (P2P-ET), an overvoltage problem may occur. In this study, a distribution system voltage management method through interaction between DSO and local energy transaction community (LETC) which performs P2P-ET is proposed. The effect of the proposed model is validated through a case study considering the LETC that local prosumers pool-based P2P-ET is performed.

The effects of Mn and C content on the age hardening of Fe–Mn–Al–C lightweight steels, which have austenitic or duplex (austenite and ferrite) microstructures, were investigated. An increase in Mn content induced a delay of the age hardening that is caused by the formation of intra-granular κ-carbides. In order to interpret the effect of Mn content, first-principles calculations were conducted using the supercells of Fe24Al8C8, Fe24Al8C7, Fe24(Al7Mn)C8, and Fe24(Al7Mn)C7. The calculations showed that an increase in Mn content could be the source of the delay of the intra-granular κ-carbide formation by suppressing C atom’ occupation of the vacancy at the body-centered site of L12. An increase in C content accelerated the formation of intra-granular κ-carbides, which induced the intense age hardening, and coarse inter-granular κ-carbides, which resulted in significant decrease in impact absorbed energy due to inter-granular fracture.

ITU-R recommends a global rain-attenuation prediction model for satellite link, but it lacks a physical meaning because it is an empirical model and the effective path-length model is frequency dependent. In this letter, a global effective path-length model, which can be used for total attenuation prediction in a satellite link, is proposed. The proposed model is a physical model based on the rain-cell concept. The test for the proposed model was performed against the data in the ITU-R SG3 DB, using the procedures in the recommendation ITU-R P. 311 and the Fascicle. The test results show that the prediction error of the proposed model is less than the existing ITU-R model. In addition, the proposed model is a physical model and simple compared to the current ITU-R model.

OBJECTIVE: To investigate the duration and peak of severe acute respiratory syndrome coronavirus 2 shedding as infectivity markers for determining the isolation period. METHODS: A total of 2,558 upper respiratory tract (URT) and lower respiratory tract (LRT) specimens from 138 patients with laboratory-confirmed coronavirus disease were analyzed. Measurements of sequential viral loads were aggregated using the cubic spline smoothing function of a generalized additive model. The time to negative conversion was compared between symptom groups using survival analysis. RESULTS: In URT samples, viral RNA levels peaked on day 4 after symptom onset and rapidly decreased until day 10 for both E and RdRp genes, whereas those in LRT samples immediately peaked from symptom onset and decreased until days 15.6 and 15.0 for E and RdRp genes, respectively. Median (interquartile range) time to negative conversion was significantly longer in symptomatic (18.0 [13.0-25.0] days) patients than in asymptomatic (13.0 [9.5-17.5] days) patients. The more types of symptoms a patient had, the longer the time to negative conversion. CONCLUSIONS: The viral load rapidly changes depending on the time after symptom onset; the viral shedding period may be longer with more clinical symptoms. Different isolation policies should be applied depending on disease severity.

Several exercise methods, such as the Shaker exercise, tongue press exercise, chin tuck against resistance (CTAR) exercise, and submandibular push exercise, have been introduced to strengthen the muscles involved in swallowing. In this study, we compared the effectiveness of the CTAR, submandibular push, and Shaker exercises for the induction of selective supra- and infrahyoid muscle contractions using surface electromyography (EMG). This study is a prospective non-randomized controlled study. Twenty-five healthy subjects and 20 patients experiencing swallowing difficulty were enrolled. During the three different types of exercises, the root mean square (RMS) values of the sternocleidomastoid (SCM), suprahyoid (anterior belly of the digastric and mylohyoid muscles), and infrahyoid (sternothyroid and thyrohyoid muscles) muscles were analyzed using surface EMG. Differences in the activity of swallowing muscles among the three different exercises were analyzed using one-way repeated measured analysis of variance. In terms of both the maximum and mean RMS values of the suprahyoid muscle, the submandibular push exercise showed a larger RMS value than the CTAR and Shaker exercises in healthy subjects (p p

Increasing penetration of networked distributed energy resources (DER) in electric power systems managed by multiparty are expanding the power system attack surface. An outstanding threat is sophisticated attackers who possess extensive knowledge of the systems and keep trying to attack DER systems, which have not been well mitigated by existing defense strategies. This paper explores a cyber kill chain model for a DER aggregation system based on a latest METRE's cyber kill chain model to model possible attack phases and requirement of defensive actions per each attack step, eventually toward detecting and neutralizing the intent of the sophisticated attackers.

In this study, the ionic and carbonaceous compounds in PM2.5 were analysed in the small residential city of Chuncheon, Korea. To identify the local sources that substantially influence PM2.5 concentrations, the samples were divided into two groups: samples with PM2.5 concentrations higher than those in the upwind metropolitan area (Seoul) and samples with lower PM2.5 concentrations. During the sampling period (December 2016&ndash, August 2018), the average PM2.5 was 23.2 &mu, g m&minus, 3, which exceeds the annual national ambient air quality standard (15 &mu, 3). When the PM2.5 concentrations were higher in Chuncheon than in Seoul, the organic carbon (OC) and elemental carbon (EC) concentrations increased the most among all the PM2.5 components measured in this study. This is attributable to secondary formation and biomass burning, because secondary OC was enhanced and water soluble OC was strongly correlated with K+, EC, and OC. A principal component analysis identified four factors contributing to PM2.5: fossil-fuel combustion, secondary inorganic and organic reactions in biomass burning plumes, crustal dust, and secondary NH4+ formation.

For digital signal processing, an analog signal should be sampled at least at the Nyquist rate. In many applications such as radar systems and software defined radios that deal with super high frequency, required sampling rates may exceed currently available analog-to-digital converters (ADCs). To increase the sampling rate time interleaved ADC (TI-ADC) systems are often used. In TI-ADC system several ADCs are interleaved to increase the sampling rate. Ideally all ADCs in the system will have the same gain. Due to imperfection of ADCs there is a gain mismatch. The gain mismatch results in spurious peaks in the spectrum and reduces the dynamic range of the TI-ADC system. In this paper we will first explain how the gain mismatch affect to the signal spectrum. We will also devise a method to estimate the gain mismatch and correct it.

Background: To date, conventional swallowing therapies and 2-channel NMES are standard treatments for dysphagia. The precise mechanism of 2-channel neuromuscular electrical stimulation (NMES) treatment has yet to be determined, and controversy remains over the efficacy. The sequential 4-channel NMES was newly developed based on the normal contractile sequence of swallowing-related muscles. Objective: To evaluate and compare the rehabilitative effectiveness of sequential 4-channel NMES with that of conventional 2-channel NMES.Methods: In this prospective randomized case-control study, 23 subjects with dysphagia were enrolled. Twelve subjects with 4-channel NMES group and eleven subjects with 2-channel NMES group completed the intervention. Pretreatment and posttreatment evaluations were performed with the videofluoroscopic dysphagia scale (VDS), penetration-aspiration scale (PAS), MD Anderson dysphagia inventory (MDADI), functional oral intake scale (FOIS), and Likert scale.Results: The sequential 4-channel NMES group significantly improved the VDS (oral, pharyngeal, and total), PAS, FOIS, and MDADI (emotional, functional, and physical scale) compared with pretreatment data. The 2-channel NMES group significantly improved the VDS (oral, pharyngeal, and total) and MDADI (emotional, physical scale), but not the PAS and FOIS compared with pretreatment data. When the two groups were directly compared, the 4-channel NMES group showed significant improvement in oral and total VDS.Conclusions: Sequential 4-channel NMES activating the suprahyoid, thyrohyoid, and other infrahyoid muscles with proper interval time can be a new effective treatment for dysphagia.Trial registration : clinicaltrial.gov, registration number: NCT03670498, registered 13 September 2018, https://clinicaltrials.gov/ct2/show/NCT03670498?term=NCT03670498&draw=2&rank=1

Background To date, conventional swallowing therapies and 2-channel neuromuscular electrical stimulation (NMES) are standard treatments for dysphagia. The precise mechanism of 2-channel NMES treatment has not been determined, and there are controversies regarding the efficacy of this therapy. The sequential 4-channel NMES was recently developed and its action is based on the normal contractile sequence of swallowing-related muscles. Objective To evaluate and compare the rehabilitative effectiveness of the sequential 4-channel NMES with that of conventional 2-channel NMES. Methods In this prospective randomized case–control study, 26 subjects with dysphagia were enrolled. All participants received 2- or 4-channel NMES for 2–3 weeks (minimal session: 7 times, treatment duration: 300–800 min). Twelve subjects in the 4-channel NMES group and eleven subjects in the 2-channel NMES group completed the intervention. Initial and follow-up evaluations were performed using the videofluoroscopic dysphagia scale (VDS), the penetration-aspiration scale (PAS), the MD Anderson dysphagia inventory (MDADI), the functional oral intake scale (FOIS), and the Likert scale. Results The sequential 4-channel NMES group experienced significant improvement in their VDS (oral, pharyngeal, and total), PAS, FOIS, and MDADI (emotional, functional, and physical subsets) scores, based on their pretreatment data. VDS (oral, pharyngeal, and total) and MDADI (emotional and physical subsets) scores, but not PAS and FOIS scores, significantly improved in the 2-channel NMES group posttreatment. When the two groups were directly compared, the 4-channel NMES group showed significant improvement in oral and total VDS scores. Conclusions The sequential 4-channel NMES, through its activation of the suprahyoid and thyrohyoid muscles, and other infrahyoid muscles mimicking physiological activation, may be a new effective treatment for dysphagia. Trial registration: clinicaltrial.gov, registration number: NCT03670498, registered 13 September 2018, https://clinicaltrials.gov/ct2/show/NCT03670498?term=NCT03670498&draw=2&rank=1.

The authors wish to make the following corrections to this paper [...]

Flow simulation over a dune requires the proper input of roughness coefficients. This study analyzed a numerical simulation of open-channel turbulent flow over two-dimensional fixed dunes to reveal the effect of roughness on the dune bottom, and to determine the optimized combination of the turbulence scheme and the roughness height formula. The most appropriate roughness values and turbulence models were applied using Reynolds-averaged Navier&ndash, Stokes models. Seven methods were chosen to estimate the bed roughness properties at the inlet boundary section. The results of all cases calculated with the OpenFOAM toolbox were compared with laboratory experimental data for model validation. The performances of all bed roughness variations were evaluated according to the stream-wise and depth-wise directions with nondimensional values. Consequently, it was revealed that the combination of bottom roughness length scale at the inlet boundary and the k-&omega, shear-stress transport (SST) model was the most suitable for the flow separation zone and turbulent properties near the channel bottom.

Development of a human-interactive display enabling the simultaneous sensing, visualisation, and memorisation of a magnetic field remains a challenge. Here we report a skin-patchable magneto-interactive electroluminescent display, which is capable of sensing, visualising, and storing magnetic field information, thereby enabling 3D motion tracking. A magnetic field-dependent conductive gate is employed in an alternating current electroluminescent display, which is used to produce non-volatile and rewritable magnetic field-dependent display. By constructing mechanically flexible arrays of magneto-interactive displays, a spin-patchable and pixelated platform is realised. The magnetic field varying along the z-axis enables the 3D motion tracking (monitoring and memorisation) on 2D pixelated display. This 3D motion tracking display is successfully used as a non-destructive surgery-path guiding, wherein a pathway for a surgical robotic arm with a magnetic probe is visualised and recorded on a display patched on the abdominal skin of a rat, thereby helping the robotic arm to find an optimal pathway., Designing human-interactive displays enabling the simultaneous sensing, visualization, and memorization of a magnetic field remains a challenge. Here, the authors present a skin-patchable magneto-interactive electroluminescent display by employing a magnetic field-dependent conductive gate, thereby enabling 3D motion tracking.

Typhoons can often cause inundation in lower coastal cities by inducing strong surges and waves. Being affected by typhoon annually, the coastal cities in South Korea are very vulnerable to typhoons. In 2016, a typhoon &lsquo, CHABA&rsquo, with a maximum 10 min sustained wind speed of about 50 m/s and a minimum central pressure of 905 hPa, hit South Korea, suffering tremendous damage. In particular, &lsquo, induced coastal inundation resulted in serious damage to the coastal area of Busan where a lot of high-rise buildings and residential areas are concentrated, and was caused by the combined effect of tide, surge, and wave. The typhoon-induced surge raised sea levels during high tide, and the strong wave with a long period of more than 10 s eventually led to the coastal inundation at the same time. The present research focuses a numerical downscaling considering the effects of tide, surge and wave for coastal inundation induced by Typhoon &lsquo, This downscaling approach applied several numerical models, which are the Weather Research and Forecasting model (WRF) for typhoon simulation, the Finite Volume Community Ocean Model (FVCOM) for tide and surge simulation, and the Simulating WAve Nearshore (SWAN) for wave simulation. In a domain covering the Korean Peninsula, typhoon-induced surges and waves were simulated applying the results simulated by WRF as meteorological conditions. In the downscaled domain ranged near the coastal area of Busan, the coastal inundation was simulated blending a storm tide height and an irregular wave height obtained from the domain, in which each height has 1 s interval. The irregular wave height was calculated using the significant wave height and peak period. Through this downscaling study, the impact of storm tide and wave on coastal inundation was estimated.

Harzburgite are the rocks that make up the mantle and consist of olivine, orthopyroxene, and clinopyroxene (

We developed a new exercise method called the submandibular push exercise that can strengthen the suprahyoid muscle by inducing only the motion of the hyoid bone without neck flexion. In this study, we aimed to investigate and compare the muscle activity of the suprahyoid and infrahyoid muscles in the course of performing three different swallowing exercises. Twenty healthy participants and fifteen patients with dysphagia were recruited. Each participant consecutively performed three exercises: Shaker, CTAR, and submandibular push exercises. To investigate muscle activation, surface electromyography was performed on the suprahyoid, infrahyoid, and SCM muscles, during the exercises. Root mean square (RMS) was measured. In healthy participants, the submandibular push exercise showed a significantly higher RMS value in the suprahyoid and infrahyoid muscles than the Shaker and CTAR exercises using repeated ANOVA with Tukey's post hoc test (p p

There have recently been an increasing number of variable renewable energy curtailment cases to manage power system stability problems caused by the overproduction of variable renewable energy. Variable renewable energy curtailment can be a factor that hinders the development of the power industry by reducing the economic viability of variable renewable energy operators and the efficiency of energy use. In this study, an economic curtailment methodology using electric vehicles to mitigate energy waste and economic losses is proposed. Charging point operators participate in incentive-based demand response programs with their charging station loads under curtailment situations. A location-based incentive algorithm considering distribution system constraints is proposed to avoid distribution system congestion. A response model based on random arrival electric vehicles considering demand and price elasticity, time pressure, and charging pressure is developed. The proposed methodology is verified through case studies based on the environment of Jeju Island in Korea. The case study results show that the proposed methodology can use energy more economically and effectively than conventional variable renewable energy curtailment methodology.

Turbulence is one of the decisive parameters that cause scouring in the river bed and threaten the foundation of hydraulic structures. And choosing the right turbulent modeling scheme is the key to simulate this flow property accurately. This study investigated a turbulent flow in a scour hole developed in a channel by using OpenFOAM toolbox. Two different turbulence schemes, k−e and k−ω, were used to evaluate the performance of turbulent schemes in simulating the turbulence property in this complex region. Beside the main turbulence schemes, the difficulties in modeling the flow close to the wall also was solved by choosing the right wall function and boundary conditions. The results from these two models, the flow velocity profiles in streamwise and water-depth directions as well as the turbulent kinetic energy, were evaluated by comparing with the physical experimental data from previous research.

Interleaved ADCs are used to increase sampling rate of available existing ADCs. By utilizing M ADCs, sampling rate can be increased by a factor of M. Interleaving of ADCs results in timing mismatch that causes nonuniform sampling. Timing mismatch correction in the frequency domain is considered in this paper. For a stationary signal the entire length of the nonuniformly sampled signal is transformed and timing mismatch is corrected in the frequency domain. Using the inverse Fourier transform, the uniformly sampled signal is reconstructed. The longer the signal, the better the performance in terms of correction. However, for a long signal long delay is required for correction. In image compression DCT is used for small blocks of an image. In this paper DCT is used to correct timing mismatch. Only M-point DCT is used for correction to minimize the delay. The experimental results show that the timing mismatch correction using DCT performs better than the DFT method.

Purpose Child safety seats (CSS) are critical for the protection of children, in case of motor vehicle accidents. Although the national legislation mandates that all newborns must be placed in an appropriately installed CSS during transportation, people often do not perceive the importance of CSS and do not use it as recommended. The purpose of this survey was to understand the use of CSS for the safe transport of newborns from hospital to home. Methods We interviewed parents of newborn infants, using a structured questionnaire, at the time of their discharge from Cheil General Hospital a Women's Health Care Center, between May 2014 and July 2014. Results A total of 403 participants were interviewed. The rate of CSS use was only 14.9%. Overall, 76.4% of the families interviewed were not aware about the recommendations on CSS use for newborns when travelling in a car. The provision of education on using CSS significantly influenced their rate of use. Parents who were educated about mounting the CSS in a car used it more as compared with others (25.7% vs. 12.2%) (P=0.002). Furthermore, if parents had heard about the importance or necessity of CSS, they used it more than others did (19.5% vs. 10.6%, P=0.032). Conclusion Despite the legal regulation, most parents transport their newborn infants without a CSS while traveling from hospital to their home. The rate of CSS use was influenced by parental education and their knowledge about its necessity. Education programs for parents must be reinforced to increase the CSS use.