Search

Your search keyword '"Sun, Shichen"' showing total 237 results
Start Over Author "Sun, Shichen"
237 results on '"Sun, Shichen"'

52. OsBBX11 on qSTS4 links to salt tolerance at the seeding stage in Oryza sativa L. ssp. Japonica

Author

Lei, Lei, primary, Cao, Liangzi, additional, Ding, Guohua, additional, Zhou, Jinsong, additional, Luo, Yu, additional, Bai, Liangming, additional, Xia, Tianshu, additional, Chen, Lei, additional, Wang, Jiangxu, additional, Liu, Kai, additional, Lei, Qingjun, additional, Xie, Tingting, additional, Yang, Guang, additional, Wang, Xueyang, additional, Sun, Shichen, additional, and Lai, Yongcai, additional

Published
2023
Full Text
View/download PDF

61. Impact of Platelets to Lymphocytes Ratio and Lymphocytes during Radical Concurrent Radiotherapy and Chemotherapy on Patients with Nonmetastatic Esophageal Squamous Cell Carcinoma

Author

Zhang, Yaotian, primary, Han, Ning, additional, Zeng, Xue, additional, Sun, Chaonan, additional, Sun, Shichen, additional, Ma, Xinchi, additional, Zhang, Yanyu, additional, Liu, Zhuang, additional, Qin, Zilan, additional, Guo, Hong, additional, Li, Yubing, additional, and Zhang, Na, additional

Published
2022
Full Text
View/download PDF

69. Chinese breast cancer patients with CYP2D6 *10 mutant genotypes have a better prognosis with toremifene than with tamoxifen

Author

Wang, Hongyue, primary, Ma, Xinchi, additional, Zhang, Bin, additional, Zhang, Yaotian, additional, Han, Ning, additional, Wei, Linlin, additional, Sun, Chaonan, additional, Sun, Shichen, additional, Zeng, Xue, additional, Guo, Hong, additional, Li, Yubing, additional, Zhang, Yanyu, additional, Zhao, Jiaming, additional, Qin, Zilan, additional, Liu, Zhuang, additional, and Zhang, Na, additional

Published
2021
Full Text
View/download PDF

70. ResNet + LSTM method for age-related macular degeneration and diabetic retinopathy diagnosis on OCT images

Author

Sun, Shichen

Subjects
genetic structures, sense organs, eye diseases
Abstract

With the fast development of medical image devices and technologies, the amount of medical image data has increased significantly at a unprecedented rate. In many clinical specialities, there can be a shortage of doctors and radiologist experts to give timely diagnosis and referral to patients when facing the large amount of medical images and data. Especially for the ophthalmology, the widespread availability of optical coherence tomography (OCT), which is a novel medical imaging technology that allow acquisition of cross-sectional images of the retina with semihistologic resolution, has not been matched by the availability of human experts to interpret scans and provide appropriate treatments. According to the National Reporting and Learning System (NRLS), there are about 250 cases of sight harm due to the diagnosis delay per year in UK. Hence, how can we improve the efficiency of clinical diagnosis is a urgent problem need to be solved.In this dissertation, we are going to present a method for classifying normal, diabetic retinopathy (DR) and age-related macular degeneration (AMD) on OCT scan sequences. Different from classic medical image classification problems, OCT is a crosssectional image sequences of eye fundus. The lesions of DR and AMD can be spatial related among OCT slices. To solve this problem and find the feature connection between OCT slices, we proposed a model that contains two neural networks. The first model is a residual neural network, which is used for extract symptom features on each OCT slices. The feature extract from each slices are combined to a series feature as the second model input. The second model is a long short-term memory neural network used for get the predictions based on OCT sequence feature. The model was trained and tested on around 1700 OCT scans, each of them has 25 slice images (Total 36149 slices). We used cross-entropy loss and k-cross validation. The result shows it has a accuracy of 1, 1, 1 on three class, respectively, when choosing the best model.

Published
2021
Full Text
View/download PDF

73. Refinement of αsphase and formation of nano-twins of Ti–7Mo–4Al–3Nb–2Cr alloyed by Zr element

Author

Li, Yili, Fang, Hongze, Sun, Shichen, Zhang, Xiaofu, Xue, Xiang, and Chen, Ruirun

Abstract

To refine the αsphase and form the nano twins, different contents of Zr were added to as-cast Ti–7Mo–4Al–3Nb–2Cr-xZr alloys. Phase and microstructure evolution, mechanical properties and related mechanisms were systematically studied. Results show that as the Zr increases from 0 to 8 wt%, only α and β phases exist and the peak of β (110) shifts from 39.5 to 39.1° by XRD. The volume fraction of the αsphase changes from 75.4 to 73.9%, and its length decreases from 0.62 to 0.22 μm. More dislocations appear in the α/β interface and the growth twin of {10 1¯1}α < 11 2¯0> type with a width of ∼20 nm forms in α phase as observed by TEM. The refinement of the αsphase is due to the addition of Zr to promote nucleation and inhibit the growth rate. With increasing Zr content from 0 to 8 wt%, the strength increases from 961 to 1303 MPa, while the toughness decreases from 77 to 62 MPa m1/2. The fracture toughness decreases by 19.5%, while the strength increases by 35.6%. The refinement of αsphase, the solubilization of the Zr in the matrix, the increase of dislocation in the α/β interface, and the formation of nano twins are the main reasons for improving the strength and toughness of the studied alloys.

Published
2022
Full Text
View/download PDF

74. Chinese breast cancer patients with CYP2D6*10 mutant genotypes have a better prognosis with toremifene than with tamoxifen.

Author

Wang, Hongyue, Ma, Xinchi, Zhang, Bin, Zhang, Yaotian, Han, Ning, Wei, Linlin, Sun, Chaonan, Sun, Shichen, Zeng, Xue, Guo, Hong, Li, Yubing, Zhang, Yanyu, Zhao, Jiaming, Qin, Zilan, Liu, Zhuang, and Zhang, Na

Subjects
HORMONE receptor positive breast cancer, SURVIVAL analysis (Biometry), CANCER patients, TAMOXIFEN, BREAST cancer, GENOTYPES
Abstract

Purpose: To evaluate the prognosis of estrogen receptor‐positive breast cancer patients with CYP2D6*10 mutant genotypes under tamoxifen or toremifen therapy. Methods: Estrogen receptor‐positive breast cancer patients were selected and CYP2D6*10 genotypes (C/C, C/T, and T/T) were determined by Sanger sequencing. Patients were divided into tamoxifen, toremifene, or tamoxifen + toremifene groups according to prior therapy. The correlation between CYP2D6*10 genotype and disease‐free survival was analyzed. Results: In total, 293 estrogen receptor‐positive breast cancer patients treated with tamoxifen or toremifene between 2008 and 2017 were studied. Median follow‐up was 39 months (10–141). Of these, 107 (36.52%), 112 (38.23%), and 74 (25.26%) patients had C/C, C/T, and T/T genotypes, respectively. Genotype was significantly associated with disease‐free survival in tamoxifen patients. Patients with C/T and T/T genotypes showed worse disease‐free survival than patients with a C/C genotype. Genotype and disease‐free survival in toremifene and tamoxifen+toremifene patients were not correlated. Of patients with a C/T genotype, toremifene or tamoxifen+toremifene groups showed better disease‐free survival than tamoxifen patients. Although disease‐free survival of patients with a T/T genotype in the three groups was not statistically different, tamoxifen patients showed worse disease‐free survival. There was no correlation between different treatments and disease‐free survival in patients with a C/C genotype. Cox proportional hazard analysis revealed toremifene patients had a better prognosis than tamoxifen patients; toremifene was an independent protective factoremifene for disease‐free survival. Conclusions: Tamoxifen was less effective in patients with CYP2D6*10 C/T and T/T genotypes. Estrogen receptor‐positive breast cancer patients with a CYP2D6*10 mutation genotype have a better prognosis with toremifen than tamoxifen. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

83. Mapping and candidate gene analysis for a new top spikelet abortion mutant in rice

Author

Zhang Fengming, Ding Guohua, Jiang Shukun, Fan Xu, Dan Liu, Jiayu Wang, Jiang Hui, Sun Shichen, Wang Tongtong, Bai Liangming, Lili Chen, Zhengjin Xu, and Xijuan Zhang

Subjects
0301 basic medicine, Genetics, Candidate gene, Glume, Bulked segregant analysis, food and beverages, Locus (genetics), Plant Science, Biology, Genetic analysis, 03 medical and health sciences, 030104 developmental biology, Lodicule, Cleaved amplified polymorphic sequence, Agronomy and Crop Science, Panicle
Abstract

Grain numbers is one of the determinations for rice yield and directly associated with spikelet numbers per panicle and its normal development. Lots of genes responsible for spikelet numbers and spikelet early development have been identified, but the molecular information about the spikelet development at later development is still limited. Here, we isolated a rice spikelet abnormal development mutant, which shows degenerated spikelet at the top panicle and named aborted top spikelet mutant 1(Ats1). The spikelets derived from the middle and bottom branches per panicle of Ats1 show normal development with those of wild type. However, a large number of branches and spikelets with arrested development were often observed only on apex panicle. The abnormality did not appear until the stage In8 when rachises elongate rapidly and reproductive organs get mature, based on observations through SEM analysis. The aborted spikelet could develop the complete floral organs with a pair of rudimentary glume, a pair of empty glume, two lodicule, six stamens and one carpel. But all these floral organs did not develop maturity. Genetic analysis on two F2 populations indicated that the Ats1 was controlled by a single dominant gene. By using bulked segregant analysis of F2 population developed from Ats1 crossing with Songjing6, ATS1 was mapped on chromosome 8 between RM3819 and RM5556. Then, the fine mapping was performed with 1078 F2 population developed from Ats1 and IR36. The ATS1 locus was finely mapped in an 85.7 kb region between RM22448 and STS8-2 with 8 genes according to the rice annotation project database. Sequence analysis of the candidate genes within the delimited region of the Ats1 and Akihikari showed two-nucleotide changes, including single-nucleotide substitutions corresponding to an amino acid substitution from asparagine to lysine acid in exons 3 and a 1-bp deletion resulting in a premature stop codon in exon 22 at the candidate gene, LOC_Os08g06480. A cleaved amplified polymorphic sequence (CAPS) marker, CAPS-ats1, was developed from the 1-bp deletion site. The complete cosegregation of the CAPS genotypes with the matching phenotypes were observed in the F2 populations. This suggested that Os08g06480 is most likely the ATS1 gene. These results will provide more information for better understanding of the molecular mechanism governing top spikelet abortion within a short developmental period.

Published
2016

94. Electrochemical Behaviors of the Electrodes for Proton Conducting Intermediate Temperature Solid Oxide Fuel Cells (IT-SOFC)

Author

Sun, Shichen and Sun, Shichen

Abstract

Proton conducting intermediate temperature (600oC-400oC) solid oxide fuel cells (IT-SOFC) have many potential advantages for clean and efficient power generation from readily available hydrocarbon fuels. However, it still has many unsolved problems, especially on the anode where the fuel got oxidized and the cathode where oxygen got reduced. In this study, for the anode, the effects of hydrogen sulfite (H2S) and carbon dioxide (CO2) as fuel contaminants were studied on the nickel (Ni) based cermet anode of proton conducting IT-SOFC using proton conducting electrolyte of BaZr0.1Ce0.7Y0.1Yb0.1O3 (BZCYYb). Both low-ppm level H2S and low-percentage level CO2 caused similar poisoning effects on the anode reaction. The H2S poisoning effect was also found to be much less than on oxide-ion conducting SOFC, which is attributed to the absence of water evolution for the anode reaction in proton conducting SOFC. In addition, the H2S/CO2 poisoning mechanisms were investigated using X-ray diffraction, energy dispersive spectroscopy (EDS), Raman spectroscopy, and secondary ion mass spectroscopy (SIMS). For H2S, other than possible sulfur dissolution into BZCYYb, no bulk reaction was found, suggesting sulfur adsorption contributes to the reduced performance. For CO2, reaction with BZCYYb to form BaCO3 and CeO2 is identified and is believed to be the reason for the sudden worsening in CO2 poisoning as temperature drops below ~550oC. For the cathode, several representative SOFC cathodes including silver (Ag), La0.6Sr0.4Co0.2Fe0.8O3-δ (LSCF), LSCF-BZCYYb composite, and Ba0.5Sr0.5Co0.8Fe0.2O3-δ (BSCF) were evaluated based on BZCYYb electrolyte. LSCF give similar high interfacial resistance as Ag, while LSCF-BZCYYb composite cathode shows lower interfacial resistance, suggesting LSCF behaves like pure electronic conductor cathode in this case. For BSCF, it shows smallest interfacial resistance and the charge transfer process appears to accelerate with the introduction of H2O, while oxyg

Published
2018

95. Power and carbon monoxide co-production by a proton-conducting solid oxide fuel cell with La0.6Sr0.2Cr0.85Ni0.15O3−δ for on-cell dry reforming of CH4 by CO2.

Author

Wei, Tong, Qiu, Peng, Jia, Lichao, Tan, Yuan, Yang, Xin, Sun, Shichen, Chen, Fanglin, and Li, Jian

Abstract

To directly use a CO2–CH4 gas mixture for power and CO co-production by proton-conducting solid oxide fuel cells (H-SOFCs), a layer of in situ reduced La0.6Sr0.2Cr0.85Ni0.15O3−δ (LSCrN@Ni) is fabricated on a Ni–BaZr0.1Ce0.7Y0.1Yb0.1O3−δ (BZCYYb) anode-supported H-SOFC (H-DASC) for on-cell CO2 dry reforming of CH4 (DRC). For demonstrating the effectiveness of LSCrN@Ni, a cell without adding the LSCrN@Ni catalyst (H-CASC) is also studied comparatively. Fueled with H2, both H-CASC and H-DASC show similar stable performance with a maximum power density ranging from 0.360 to 0.816 W cm−2 at temperatures between 550 and 700 °C. When CO2–CH4 is used as the fuel, the performance and stability of H-CASC decreases considerably with a maximum power density of 0.287 W cm−2 at 700 °C and a sharp drop in cell voltage from the initial 0.49 to 0.10 V within 20 h at 0.6 A cm−2. In contrast, H-DASC demonstrates a maximum power density of 0.605 W cm−2 and a stable cell voltage above 0.65 V for 65 h. This is attributed to highly efficient on-cell DRC by LSCrN@Ni. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results