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7,232 results on '"Sun, Lu"'

51. Proteomic landscape of epithelial ovarian cancer

Author

Qian, Liujia, Zhu, Jianqing, Xue, Zhangzhi, Zhou, Yan, Xiang, Nan, Xu, Hong, Sun, Rui, Gong, Wangang, Cai, Xue, Sun, Lu, Ge, Weigang, Liu, Yufeng, Su, Ying, Lin, Wangmin, Zhan, Yuecheng, Wang, Junjian, Song, Shuang, Yi, Xiao, Ni, Maowei, Zhu, Yi, Hua, Yuejin, Zheng, Zhiguo, and Guo, Tiannan

Published
2024
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69. Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy: A Multicenter Double-Blind Randomized Controlled Trial

Author

Huang, Hao-yue, Lin, Yu-ping, Wei, Hua, Fu, Yu, Zhou, Yue-hong, Fang, Zhao-hui, Qiu, Xiao-tang, Wang, Mei, Li, Qing-bo, Li, Shan-shan, Wang, Shi-dong, Dai, Fang, Liu, Zhen-jie, Zhao, Ling, Wen, Jian-xuan, Wu, Li-yan, Zeng, Hui-yan, Zhang, Jin-ming, Lu, Qi-yun, He, Liu, Song, Wei, Sun, Lu, Luo, Lu-lu, He, Jia-li, Xie, Wen-wen, Liang, Qing-shun, Huang, Yuan, Zhu, Sheng-ling, Long, Jie-er, Gao, Zhi-juan, Wen, Ze-huai, Li, Chun-ji, Ouyang, Wen-wei, Li, Geng, Wu, Ming-hui, Li, An-xiang, Huang, Jin-zhu, Paul, Sanjoy K., Tang, Xian-yu, and Fan, Guan-jie

Published
2024
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72. Face Forgery Detection Based on Facial Region Displacement Trajectory Series

Author

Sun, YuYang, Zhang, ZhiYong, Echizen, Isao, Nguyen, Huy H., Qiu, ChangZhen, and Sun, Lu

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence
Abstract

Deep-learning-based technologies such as deepfakes ones have been attracting widespread attention in both society and academia, particularly ones used to synthesize forged face images. These automatic and professional-skill-free face manipulation technologies can be used to replace the face in an original image or video with any target object while maintaining the expression and demeanor. Since human faces are closely related to identity characteristics, maliciously disseminated identity manipulated videos could trigger a crisis of public trust in the media and could even have serious political, social, and legal implications. To effectively detect manipulated videos, we focus on the position offset in the face blending process, resulting from the forced affine transformation of the normalized forged face. We introduce a method for detecting manipulated videos that is based on the trajectory of the facial region displacement. Specifically, we develop a virtual-anchor-based method for extracting the facial trajectory, which can robustly represent displacement information. This information was used to construct a network for exposing multidimensional artifacts in the trajectory sequences of manipulated videos that is based on dual-stream spatial-temporal graph attention and a gated recurrent unit backbone. Testing of our method on various manipulation datasets demonstrated that its accuracy and generalization ability is competitive with that of the leading detection methods.

Published
2022

73. Multi-objective Deployment of WSNs in Underground Sheltered Space

Author

Wan, Liangtian, Wang, Caiyun, Sun, Lu, Chen, Boyu, Zheng, Jibin, Wang, Xianpeng, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Leung, Victor C.M., editor, Li, Hezhang, editor, Hu, Xiping, editor, and Ning, Zhaolong, editor

Published
2024
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74. A Novel Method for Semantic Segmentation on Lidar Point Clouds

Author

Wang, Fei, Wan, Liangtian, Zhu, Yan, Sun, Lu, Zhao, Xiaowei, Zheng, Jianbo, Wang, Xianpeng, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Leung, Victor C.M., editor, Li, Hezhang, editor, Hu, Xiping, editor, and Ning, Zhaolong, editor

Published
2024
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75. Joint Delay and Energy Optimization for WPT-MEC System Based on Immune Algorithm

Author

Sun, Lu, Li, Dianju, Lu, Hao, Wan, Liangtian, Zheng, Jianbo, Wang, Xianpeng, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Leung, Victor C.M., editor, Li, Hezhang, editor, Hu, Xiping, editor, and Ning, Zhaolong, editor

Published
2024
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76. Efficient Joint Deployment of Multi-UAVs for Target Tracking

Author

Wang, Jiashuai, Sun, Lu, Wan, Liangtian, Zheng, Jibin, Wang, Xianpeng, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Leung, Victor C.M., editor, Li, Hezhang, editor, Hu, Xiping, editor, and Ning, Zhaolong, editor

Published
2024
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77. Comprehensive Evaluation Approach for the Coordinated Development of Urban Bus and Metro Based on Entropy-TOPSIS Method

Author

Zhu, Jinrui, Zhao, Jiannan, Ding, Shengxuan, Sun, Lu, Yang, Yang, Li, Zhen, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Wang, Wuhong, editor, Jin, Lisheng, editor, and Tan, Haiqiu, editor

Published
2024
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78. Deep Learning-Based Joint Channel Estimation and Implicit CSI Feedback

Author

Wan, Liangtian, He, Jifeng, Liu, Kaihui, Sun, Lu, Wang, Xianpeng, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, and Chinese Institute of Command and Control, editor

Published
2024
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79. Partial Multi-label Learning with a Few Accurately Labeled Data

Author

Mizuguchi, Haruhi, Kimura, Keigo, Kudo, Mineichi, Sun, Lu, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Liu, Fenrong, editor, Sadanandan, Arun Anand, editor, Pham, Duc Nghia, editor, Mursanto, Petrus, editor, and Lukose, Dickson, editor

Published
2024
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80. Incomplete Multi-view Weak-Label Learning with Noisy Features and Imbalanced Labels

Author

Li, Zhiwei, Yang, Zijian, Sun, Lu, Kudo, Mineichi, Kimura, Keigo, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Liu, Fenrong, editor, Sadanandan, Arun Anand, editor, Pham, Duc Nghia, editor, Mursanto, Petrus, editor, and Lukose, Dickson, editor

Published
2024
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81. A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events

Author

Estep, Jason A, Sun, Lu O, and Riccomagno, Martin M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Integrin adhesion complexes, Focal adhesions, Focal adhesion kinase, Integrin, Cell migration, Cell motility, Luciferase fragment complementation assay, Split luciferase
Abstract

Integrin Adhesion Complexes (IACs) serve as links between the cytoskeleton and extracellular environment, acting as mechanosensing and signaling hubs. As such, IACs participate in many aspects of cellular motility, tissue morphogenesis, anchorage-dependent growth and cell survival. Focal Adhesion Kinase (FAK) has emerged as a critical organizer of IAC signaling events due to its early recruitment and diverse substrates, and thus has become a genetic and therapeutic target. Here we present the design and characterization of simple, reversible, and scalable Bimolecular Complementation sensors to monitor FAK phosphorylation in living cells. These probes provide novel means to quantify IAC signaling, expanding on the currently available toolkit for interrogating FAK phosphorylation during diverse cellular processes.

Published
2023

85. Transcriptional differential analysis of ocular surface ectoderm and surface ectoderm

Author

Sun Lu, Zhang Canwei, Song Yuwen, Li Jianxin, Duan Lian, Gao Yang, Xie Yuemei, Wang Luping, and Dang Guangfu

Subjects
ocular surface ectoderm, surface ectoderm, transcriptome, differential expressed genes, signaling pathways, Ophthalmology, RE1-994
Abstract

AIM:To identify transcriptional differences between the ocular surface ectoderm(OSE)and surface ectoderm(SE)using RNA-seq, and elucidate the OSE transcriptome landscape and the regulatory networks involved in its development.METHODS:OSE and SE cells were differentiated from human embryonic stem(hES)cells. Differentially expressed genes(DEGs)between OSE and SE were analyzed using RNA-seq. Based on the DEGs, we performed gene ontology(GO)analysis, Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis, and protein-protein interaction(PPI)network analysis. Transcription factors(TFs)and hub genes were screened. Subsequently, TF-gene and TF-miRNA regulatory networks were constructed using the NetworkAnalyst platform.RESULTS:A total of 4 182 DEGs were detected between OSE and SE cells, with 2 771 up-regulated and 1 411 down-regulated genes in OSE cells. GO-BP analysis revealed that up-regulated genes in OSE were enriched in the regulation of ion transmembrane transport, axon development, and modulation of chemical synaptic transmission. Down-regulated genes were primarily involved in nuclear division, chromosome segregation, and regulation of cell cycle phase transition. KEGG analysis indicated that up-regulated genes in OSE cells were enriched in signaling pathways such as cocaine addiction, axon guidance, and amphetamine addiction, while down-regulated genes were enriched in proteoglycans in cancer, ECM-receptor interaction, protein digestion and absorption, and cytokine-cytokine receptor interaction. Additionally, compared with SE, 204 TFs(including FOS, EGR1, POU5F1, SOX2, and PAX6)were up-regulated, and 80 TFs(including HAND2, HOXB6, HOXB5, HOXA5, and HOXB8)were down-regulated in OSE cells. Furthermore, we identified 6 up-regulated and 9 down-regulated hub genes in OSE cells, and constructed TF-gene and TF-miRNA regulatory networks based on these hub genes.CONCLUSIONS:The transcriptome characteristics of OSE and SE cells were elucidated through RNA-seq analysis. These findings may provide a novel insight for studies on the development and in vitro directed induction of OSE and corneal epithelial cells.

Published
2024
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86. Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors

Author

Ding, Lizhong, Sun, Lu, Bu, Melissa T, Zhang, Yanjun, Scott, Lauren N, Prins, Robert M, Su, Maureen A, Lechner, Melissa G, and Hugo, Willy

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Clinical Research, Immunotherapy, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Inflammatory and immune system, Good Health and Well Being, Humans, Immune Checkpoint Inhibitors, Antigen Presentation, Leukocytes, Mononuclear, CD8-Positive T-Lymphocytes, Receptors, Antigen, B-Cell, Melanoma, Tumor Microenvironment, Receptors, CXCR5, melanoma, immunotherapy, checkpoint inhibitors, interferon gamma pathway, tertiary lymphoid structure, T cell, B cell, antigen presentation, Medical Microbiology, Biochemistry and cell biology, Genetics
Abstract

IntroductionIncreased T cell infiltration and interferon gamma (IFNγ) pathway activation are seen in tumors of melanoma patients who respond to ICI (immune checkpoint inhibitor) or MAPK pathway inhibitor (MAPKi) therapies. Yet, the rate of durable tumor control after ICI is almost twice that of MAPKi, suggesting that additional mechanisms may be present in patients responding to ICI therapy that are beneficial for anti-tumor immunity.MethodsWe used transcriptional analysis and clinical outcomes from patients treated with ICI or MAPKi therapies to delineate immune mechanisms driving tumor response.ResultsWe discovered response to ICI is associated with CXCL13-driven recruitment of CXCR5+ B cells with significantly higher clonal diversity than MAPKi. Our in vitro data indicate that CXCL13 production was increased in human peripheral blood mononuclear cells by anti-PD1, but not MAPKi, treatment. Higher B cell infiltration and B cell receptor (BCR) diversity allows presentation of diverse tumor antigens by B cells, resulting in activation of follicular helper CD4 T cells (Tfh) and tumor reactive CD8 T cells after ICI therapy. Higher BCR diversity and IFNγ pathway score post-ICI are associated with significantly longer patient survival compared to those with either one or none.ConclusionsResponse to ICI, but not to MAPKi, depends on the recruitment of CXCR5+ B cells into the tumor microenvironment and their productive tumor antigen presentation to follicular helper and cytotoxic, tumor reactive T cells. Our study highlights the potential of CXCL13 and B cell based strategies to enhance the rate of durable response in melanoma patients treated with ICI.

Published
2023

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