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Characterization and antitumor activity of basic fibroblast growth factor-mediated active targeting doxorubicin microbubbles (bFGF-DOX-MB) were investigated. Pluronic F68 with chemical conjugation of doxorubicin (DOX-P) and peptide KRTGQYKLC-conjugated DSPE-PEG2000 were prepared. bFGF-DOX-MB had a normal distribution of particle size, with average particle size of 2.7 μm. Using A549 mouse model, bFGF-DOX-MB combined ultrasound showed the best inhibition effect on tumor volume growth among all the test groups. Similar conclusion was obtained from experimental measurements of tumor weight change and blood cell count. From the results, chemotherapeutic drug inhibition on tumor growth could be enhanced by local ultrasound combined with active targeting bFGF-DOX-MB, which might provide a potential application for ultrasound-mediated chemotherapy. [ABSTRACT FROM AUTHOR]

An in vivo study on enhancing epirubicin hydrochloride (EPI) inhibition on tumor growth by ultrasound (US) was reported. Five-week-old male nude mice were used and HL-60 cells were s.c. (subcutaneous injection) inoculated in axilla of these mice. Six groups were designed and five consecutive treatments were applied to investigate the inhibition on tumor growth and body weight growth. US applied locally to the tumor resulted in a substantially increased drug uptake in tumor cells. The inhibition on tumor growth depended on the position of drug injection and phospholipid-based microbubble (PMB) application. Tumor growth rate under group 1 (PMB+US) was similar to that of blank control. The order of the inhibition on tumor volume growth was: group 4 (s.c. EPI+PMB+US) > group 5 intraperitoneal (i.p. EPI+PMB+US) > group 2 (i.p. EPI) > group 3 (s.c. EPI+US) > group 1 (PMB+US). Similar conclusion was obtained from experimental measurements of tumor weight change. The order of animal survival status for EPI administration groups was: group 4 > group 5 > group 2 > group 3. Chemotherapeutic drug inhibition on tumor growth could be enhanced by local US combined with PMB, which might provide a potential application for US-mediated chemotherapy. [ABSTRACT FROM AUTHOR]

PURPOSE: To evaluate the clinical effects between gold-alloy post-core-crowns and nickel-chromium-alloy post-core-crowns. METHODS: Four hundred incisors, canines and premolars from 289 patients were selected. The crown had been destroyed seriously and root canal therapy was carried out. The root canal and the surface of the root were prepared well, then silicone impression material was injected into the root canal and the prepared plastic pin was inserted. Precise impression was taken and divided into two groups randomly. Group A was restored by gold-alloy post-core-crowns, while Group B was restored by nickel-chromium-alloy post-core-crowns. The patients were followed up for 3 years, the clinical effects were evaluated and compared using SPSS10.0 software package for Chi-square test. RESULTS: There was no significant difference (P>0.05) of maintenance rate between the two groups, but there was significant difference (P<0.05) in the occurrence of inflammation and staining of gingiva. CONCLUSION: Gold-alloy post-core-crown is more suitable for restoration of teeth defects than nickel-chromium-alloy post-core-crown. Supported by Research Fund of Medical Science and Technology of Guangdong Province (Grant No. WSTJJ20070101310103196603041632). [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the clinical effects between gold-alloy post-core-crowns and nickel-chromium-alloy post-core-crowns., Methods: Four hundred incisors, canines and premolars from 289 patients were selected. The crown had been destroyed seriously and root canal therapy was carried out. The root canal and the surface of the root were prepared well, then silicone impression material was injected into the root canal and the prepared plastic pin was inserted. Precise impression was taken and divided into two groups randomly. Group A was restored by gold-alloy post-core-crowns, while Group B was restored by nickel-chromium-alloy post-core-crowns. The patients were followed up for 3 years, the clinical effects were evaluated and compared using SPSS10.0 software package for Chi-square test., Results: There was no significant difference(P>0.05) of maintenance rate between the two groups, but there was significant difference (P<0.05) in the occurence of inflammation and staining of gingiva., Conclusion: Gold-alloy post-core-crown is more suitable for restoration of teeth defects than nickel-chromium-alloy post-core-crown. Supported by Research Fund of Medical Science and Technology of Guangdong Province (Grant No. WSTJJ20070101310103196603041632).