Search

Your search keyword '"Sugiura K"' showing total 2,247 results
Start Over Author "Sugiura K"
2,247 results on '"Sugiura K"'

65. Fatigue Life Estimation of Existing Bridge Using 3-D FEM and Live Load Simulation

Author

Furuta, H., Sugiura, K., Watanabe, E., Nakahara, T., Brebbia, C. A., editor, Orszag, S. A., editor, Argyris, J., editor, Bathe, K.-J., editor, Cakmak, A. S., editor, Connor, J., editor, McCrory, R., editor, Desai, C. S., editor, Holz, K.-P., editor, Leckie, F. A., editor, Pinder, G., editor, Pont, A. R. S., editor, Seinfeld, J. H., editor, Silvester, P., editor, Spanos, P., editor, Wunderlich, W., editor, Yip, S., editor, Rackwitz, Rüdiger, editor, and Thoft-Christensen, Palle, editor

Published
1992
Full Text
View/download PDF

96. Vector HTS-SQUID system for ULF magnetic field monitoring

Author

Machitani, Y., Kasai, N., Fujinawa, H., Iitaka, H., Shirai, N., Hatsukade, Y., Nomura, K., Sugiura, K., Ishiyama, A., and Nemoto, T.

Subjects
Superconductive devices -- Research, Earthquake prediction -- Research, Magnetic fields -- Research, Magnetic fields -- Measurement, Business, Electronics, Electronics and electrical industries
Abstract

A system which uses HTS-SQUIDs for environmental magnetic field monitoring is described and discussed.

Published
2003

99. Cutaneous ischemia‐reperfusion injury is exacerbated by IL‐36 receptor antagonist deficiency.

Author

Tanaka, Y., Iwata, Y., Saito, K., Fukushima, H., Watanabe, S., Hasegawa, Y., Akiyama, M., and Sugiura, K.

Subjects
GENE expression, TISSUE wounds, TOLL-like receptors, REPERFUSION injury, WOUND healing, KERATINOCYTES
Abstract

Background: Loss‐of‐function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin‐36 receptor antagonist (IL‐36Ra), has been implicated in the pathogenesis of skin disorders. However, the pathogenic role of IL‐36Ra in cutaneous ischemia‐reperfusion (I/R) injury remains unclear. Objectives: We investigated the role of IL36Ra in cutaneous I/R injury. Methods: We examined I/R injury in Il36rn−/− mice. The area of wounds, numbers of infiltrated cells, apoptotic cells and neutrophil extracellular trap (NET) formation were assessed. The expression levels of various genes were analysed using real‐time RT‐PCR. The expression of high mobility group box 1 (HMGB1), an endogenous toll‐like receptor (TLR) 4 ligand, was confirmed using immunohistology, and serum HMGB1 levels were measured by ELISA. Cytokine production by stimulated cultured J774A.1 and HaCaT cells was examined. Results: IL‐36Ra deficiency resulted in significantly delayed wound healing and increased neutrophil and macrophage infiltration into the wound tissues. Il36rn−/− mice had increased mRNA expression levels of CXCL1, CXCL2, CCL4, TNF‐α, TGF‐β, IL‐1β, IL‐6 and IL‐36γ relative to wild‐type mice. Apoptosis was identified in keratinocytes by TUNEL assay. HMGB1 expression in the I/R site was decreased in both keratinocytes and adnexal cells, while serum HMGB1 levels were significantly elevated after reperfusion. The mRNA levels of various cytokines, including IL‐1β, were elevated in J774A.1 cells through TLR4 signalling by HMGB1 stimulation. In addition, HaCaT cells stimulated with IL‐1β showed significantly increased CXCL1, TNF‐α, IL‐6, IL‐36β and IL‐36γ mRNA expression. Furthermore, NET formation was increased by IL‐36Ra deficiency. Finally, either the blockade of TLR4 signalling by TAK‐242 or inhibition of NET formation by Cl‐amidine normalized exacerbated I/R injury in Il36rn−/− mice. Conclusions: This study indicated that IL‐36Ra deficiency exacerbates cutaneous I/R injury due to excessive inflammatory cell recruitment, NET formation, and excessive cytokine and chemokine production via the TLR4 pathway by HMGB1 released from epidermal apoptotic cells. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results