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55. List of Contributors

Author

Akst, Lee M., primary, Arrow, Alexander K., additional, Awad, Mahmoud Issam, additional, Benoist, Linda, additional, Bliznikas, Darius, additional, Van Den Boer, C., additional, Bonzelaar, Lauren, additional, Boyd, Kevin, additional, Brietzke, Scott E., additional, Cahali, Michel B., additional, Candido, Kenneth D., additional, Capasso, Robson, additional, Chang, Jolie L., additional, Chou, Courtney T., additional, Collop, Nancy, additional, Cristel, Robert T., additional, Culver, Stephanie, additional, Desinger, Kai, additional, Eliachar, Isaac, additional, Fairbanks, David N.F., additional, Friedman, Michael, additional, Friedman, Norman R., additional, Galusca, Dragos M., additional, Gillespie, M. Boyd, additional, Goh, Yau Hong, additional, Goldberg, Andrew N., additional, Green, Katherine K., additional, Guilleminault, Christian, additional, Han, Demin, additional, Huntley, Tod C., additional, Huon, Leh-Kiong, additional, Huyett, Phillip, additional, Isaiah, Amal, additional, Ishman, Stacey L., additional, Jacobowitz, Ofer, additional, Kacker, Ashutosh, additional, Katsantonis, George P., additional, Kelley, Peggy E., additional, Kelly, John, additional, Kent, David, additional, Ketharanathan, Naomi, additional, Kezirian, Eric J., additional, Koltai, Peter J., additional, Krespi, Yosef P., additional, Kusper, Teresa M., additional, Li, Hsueh-Yu, additional, Li, Yanru, additional, Lin, Ho-Sheng, additional, Lin, Hsin-Ching, additional, Liu, Stanley Yung-Chuan, additional, Lorenz, Robert R., additional, van Maanen, J Peter, additional, Mair, Eric A., additional, Maisel, Robert H., additional, Mantovani, Mario, additional, Maurer, Joachim T., additional, Meccariello, Giuseppe, additional, Messina-Doucet, Maria T., additional, Mikals, Samantha J., additional, Mickelson, Samuel A., additional, Mitchell, Ron B., additional, Montevecchi, Filippo, additional, Muntz, Harlan R., additional, Pang, Kenny P., additional, Parikh, Sanjay R., additional, Pignataro, Lorenzo, additional, Powell, Nelson B., additional, Prosser, J. Drew, additional, Rataiczak, Holly, additional, Ravesloot, Madeline J.L., additional, Riley, Robert W., additional, Robinson, Sam, additional, Rotenberg, Brian W., additional, Salapatas, Anna M., additional, Shangold, Lee, additional, Skirko, Jonathan R., additional, Soose, Ryan J., additional, Steitz, Jeffery T., additional, Stuck, Boris A., additional, Thaler, Erica R., additional, Toriumi, Dean M., additional, Troell, Robert J., additional, Troung, Mai Thy, additional, Vicini, Claudio, additional, Volpi, David O., additional, de Vries, Nico, additional, Wang, Jun, additional, Winston, Tan, additional, Woodson, B. Tucker, additional, Yaremchuk, Kathleen L., additional, Ye, JingYing, additional, Yoon, Audrey Jung-Sun, additional, and Zaghi, Souroush, additional

Published
2020
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59. Generation of a Syngeneic Heterozygous ACVRL1(wt/mut) Knockout iPS Cell Line for the In Vitro Study of HHT2-Associated Angiogenesis

Author

Xiang-Tischhauser, Li, primary, Bette, Michael, additional, Rusche, Johanna R., additional, Roth, Katrin, additional, Kasahara, Norio, additional, Stuck, Boris A., additional, Bakowsky, Udo, additional, Wartenberg, Maria, additional, Sauer, Heinrich, additional, Geisthoff, Urban W., additional, and Mandic, Robert, additional

Published
2023
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70. Supplementary Table 2 from Clinical Predictors for Germline Mutations in Head and Neck Paraganglioma Patients: Cost Reduction Strategy in Genetic Diagnostic Process as Fall-Out

Author

Neumann, Hartmut P.H., primary, Erlic, Zoran, primary, Boedeker, Carsten C., primary, Rybicki, Lisa A., primary, Robledo, Mercedes, primary, Hermsen, Mario, primary, Schiavi, Francesca, primary, Falcioni, Maurizio, primary, Kwok, Pingling, primary, Bauters, Catherine, primary, Lampe, Karen, primary, Fischer, Markus, primary, Edelman, Emily, primary, Benn, Diana E., primary, Robinson, Bruce G., primary, Wiegand, Stefanie, primary, Rasp, Gerd, primary, Stuck, Boris A., primary, Hoffmann, Michael M., primary, Sullivan, Maren, primary, Sevilla, Maria A., primary, Weiss, Marjan M., primary, Peczkowska, Mariola, primary, Kubaszek, Agata, primary, Pigny, Pascal, primary, Ward, Robyn L., primary, Learoyd, Diana, primary, Croxson, Michael, primary, Zabolotny, Dmitry, primary, Yaremchuk, Svetlana, primary, Draf, Wolfgang, primary, Muresan, Mihaela, primary, Lorenz, Robert R., primary, Knipping, Stephan, primary, Strohm, Michael, primary, Dyckhoff, Gerhard, primary, Matthias, Christoph, primary, Reisch, Nicole, primary, Preuss, Simon F., primary, Eβer, Dirk, primary, Walter, Martin A., primary, Kaftan, Holger, primary, Stöver, Timo, primary, Fottner, Christian, primary, Gorgulla, Harald, primary, Malekpour, Mahdi, primary, Zarandy, Masoud Motasaddi, primary, Schipper, Jörg, primary, Brase, Christoph, primary, Glien, Alexander, primary, Kühnemund, Matthias, primary, Koscielny, Sven, primary, Schwerdtfeger, Peter, primary, Välimäki, Matti, primary, Szyfter, Witold, primary, Finckh, Ulrich, primary, Zerres, Klaus, primary, Cascon, Alberto, primary, Opocher, Giuseppe, primary, Ridder, Gerd J., primary, Januszewicz, Andrzej, primary, Suarez, Carlos, primary, and Eng, Charis, primary

Published
2023
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71. Other Supporting Colleagues from Clinical Predictors for Germline Mutations in Head and Neck Paraganglioma Patients: Cost Reduction Strategy in Genetic Diagnostic Process as Fall-Out

Author

Neumann, Hartmut P.H., primary, Erlic, Zoran, primary, Boedeker, Carsten C., primary, Rybicki, Lisa A., primary, Robledo, Mercedes, primary, Hermsen, Mario, primary, Schiavi, Francesca, primary, Falcioni, Maurizio, primary, Kwok, Pingling, primary, Bauters, Catherine, primary, Lampe, Karen, primary, Fischer, Markus, primary, Edelman, Emily, primary, Benn, Diana E., primary, Robinson, Bruce G., primary, Wiegand, Stefanie, primary, Rasp, Gerd, primary, Stuck, Boris A., primary, Hoffmann, Michael M., primary, Sullivan, Maren, primary, Sevilla, Maria A., primary, Weiss, Marjan M., primary, Peczkowska, Mariola, primary, Kubaszek, Agata, primary, Pigny, Pascal, primary, Ward, Robyn L., primary, Learoyd, Diana, primary, Croxson, Michael, primary, Zabolotny, Dmitry, primary, Yaremchuk, Svetlana, primary, Draf, Wolfgang, primary, Muresan, Mihaela, primary, Lorenz, Robert R., primary, Knipping, Stephan, primary, Strohm, Michael, primary, Dyckhoff, Gerhard, primary, Matthias, Christoph, primary, Reisch, Nicole, primary, Preuss, Simon F., primary, Eβer, Dirk, primary, Walter, Martin A., primary, Kaftan, Holger, primary, Stöver, Timo, primary, Fottner, Christian, primary, Gorgulla, Harald, primary, Malekpour, Mahdi, primary, Zarandy, Masoud Motasaddi, primary, Schipper, Jörg, primary, Brase, Christoph, primary, Glien, Alexander, primary, Kühnemund, Matthias, primary, Koscielny, Sven, primary, Schwerdtfeger, Peter, primary, Välimäki, Matti, primary, Szyfter, Witold, primary, Finckh, Ulrich, primary, Zerres, Klaus, primary, Cascon, Alberto, primary, Opocher, Giuseppe, primary, Ridder, Gerd J., primary, Januszewicz, Andrzej, primary, Suarez, Carlos, primary, and Eng, Charis, primary

Published
2023
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72. Supplementary Table 1 from Clinical Predictors for Germline Mutations in Head and Neck Paraganglioma Patients: Cost Reduction Strategy in Genetic Diagnostic Process as Fall-Out

Author

Neumann, Hartmut P.H., primary, Erlic, Zoran, primary, Boedeker, Carsten C., primary, Rybicki, Lisa A., primary, Robledo, Mercedes, primary, Hermsen, Mario, primary, Schiavi, Francesca, primary, Falcioni, Maurizio, primary, Kwok, Pingling, primary, Bauters, Catherine, primary, Lampe, Karen, primary, Fischer, Markus, primary, Edelman, Emily, primary, Benn, Diana E., primary, Robinson, Bruce G., primary, Wiegand, Stefanie, primary, Rasp, Gerd, primary, Stuck, Boris A., primary, Hoffmann, Michael M., primary, Sullivan, Maren, primary, Sevilla, Maria A., primary, Weiss, Marjan M., primary, Peczkowska, Mariola, primary, Kubaszek, Agata, primary, Pigny, Pascal, primary, Ward, Robyn L., primary, Learoyd, Diana, primary, Croxson, Michael, primary, Zabolotny, Dmitry, primary, Yaremchuk, Svetlana, primary, Draf, Wolfgang, primary, Muresan, Mihaela, primary, Lorenz, Robert R., primary, Knipping, Stephan, primary, Strohm, Michael, primary, Dyckhoff, Gerhard, primary, Matthias, Christoph, primary, Reisch, Nicole, primary, Preuss, Simon F., primary, Eβer, Dirk, primary, Walter, Martin A., primary, Kaftan, Holger, primary, Stöver, Timo, primary, Fottner, Christian, primary, Gorgulla, Harald, primary, Malekpour, Mahdi, primary, Zarandy, Masoud Motasaddi, primary, Schipper, Jörg, primary, Brase, Christoph, primary, Glien, Alexander, primary, Kühnemund, Matthias, primary, Koscielny, Sven, primary, Schwerdtfeger, Peter, primary, Välimäki, Matti, primary, Szyfter, Witold, primary, Finckh, Ulrich, primary, Zerres, Klaus, primary, Cascon, Alberto, primary, Opocher, Giuseppe, primary, Ridder, Gerd J., primary, Januszewicz, Andrzej, primary, Suarez, Carlos, primary, and Eng, Charis, primary

Published
2023
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73. Data from Clinical Predictors for Germline Mutations in Head and Neck Paraganglioma Patients: Cost Reduction Strategy in Genetic Diagnostic Process as Fall-Out

Author

Neumann, Hartmut P.H., primary, Erlic, Zoran, primary, Boedeker, Carsten C., primary, Rybicki, Lisa A., primary, Robledo, Mercedes, primary, Hermsen, Mario, primary, Schiavi, Francesca, primary, Falcioni, Maurizio, primary, Kwok, Pingling, primary, Bauters, Catherine, primary, Lampe, Karen, primary, Fischer, Markus, primary, Edelman, Emily, primary, Benn, Diana E., primary, Robinson, Bruce G., primary, Wiegand, Stefanie, primary, Rasp, Gerd, primary, Stuck, Boris A., primary, Hoffmann, Michael M., primary, Sullivan, Maren, primary, Sevilla, Maria A., primary, Weiss, Marjan M., primary, Peczkowska, Mariola, primary, Kubaszek, Agata, primary, Pigny, Pascal, primary, Ward, Robyn L., primary, Learoyd, Diana, primary, Croxson, Michael, primary, Zabolotny, Dmitry, primary, Yaremchuk, Svetlana, primary, Draf, Wolfgang, primary, Muresan, Mihaela, primary, Lorenz, Robert R., primary, Knipping, Stephan, primary, Strohm, Michael, primary, Dyckhoff, Gerhard, primary, Matthias, Christoph, primary, Reisch, Nicole, primary, Preuss, Simon F., primary, Eβer, Dirk, primary, Walter, Martin A., primary, Kaftan, Holger, primary, Stöver, Timo, primary, Fottner, Christian, primary, Gorgulla, Harald, primary, Malekpour, Mahdi, primary, Zarandy, Masoud Motasaddi, primary, Schipper, Jörg, primary, Brase, Christoph, primary, Glien, Alexander, primary, Kühnemund, Matthias, primary, Koscielny, Sven, primary, Schwerdtfeger, Peter, primary, Välimäki, Matti, primary, Szyfter, Witold, primary, Finckh, Ulrich, primary, Zerres, Klaus, primary, Cascon, Alberto, primary, Opocher, Giuseppe, primary, Ridder, Gerd J., primary, Januszewicz, Andrzej, primary, Suarez, Carlos, primary, and Eng, Charis, primary

Published
2023
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74. Supplementary Table 1 Legends and References from Clinical Predictors for Germline Mutations in Head and Neck Paraganglioma Patients: Cost Reduction Strategy in Genetic Diagnostic Process as Fall-Out

Author

Neumann, Hartmut P.H., primary, Erlic, Zoran, primary, Boedeker, Carsten C., primary, Rybicki, Lisa A., primary, Robledo, Mercedes, primary, Hermsen, Mario, primary, Schiavi, Francesca, primary, Falcioni, Maurizio, primary, Kwok, Pingling, primary, Bauters, Catherine, primary, Lampe, Karen, primary, Fischer, Markus, primary, Edelman, Emily, primary, Benn, Diana E., primary, Robinson, Bruce G., primary, Wiegand, Stefanie, primary, Rasp, Gerd, primary, Stuck, Boris A., primary, Hoffmann, Michael M., primary, Sullivan, Maren, primary, Sevilla, Maria A., primary, Weiss, Marjan M., primary, Peczkowska, Mariola, primary, Kubaszek, Agata, primary, Pigny, Pascal, primary, Ward, Robyn L., primary, Learoyd, Diana, primary, Croxson, Michael, primary, Zabolotny, Dmitry, primary, Yaremchuk, Svetlana, primary, Draf, Wolfgang, primary, Muresan, Mihaela, primary, Lorenz, Robert R., primary, Knipping, Stephan, primary, Strohm, Michael, primary, Dyckhoff, Gerhard, primary, Matthias, Christoph, primary, Reisch, Nicole, primary, Preuss, Simon F., primary, Eβer, Dirk, primary, Walter, Martin A., primary, Kaftan, Holger, primary, Stöver, Timo, primary, Fottner, Christian, primary, Gorgulla, Harald, primary, Malekpour, Mahdi, primary, Zarandy, Masoud Motasaddi, primary, Schipper, Jörg, primary, Brase, Christoph, primary, Glien, Alexander, primary, Kühnemund, Matthias, primary, Koscielny, Sven, primary, Schwerdtfeger, Peter, primary, Välimäki, Matti, primary, Szyfter, Witold, primary, Finckh, Ulrich, primary, Zerres, Klaus, primary, Cascon, Alberto, primary, Opocher, Giuseppe, primary, Ridder, Gerd J., primary, Januszewicz, Andrzej, primary, Suarez, Carlos, primary, and Eng, Charis, primary

Published
2023
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76. German S3 Guideline Nonrestorative Sleep/Sleep Disorders, chapter “Sleep-Related Breathing Disorders in Adults,” short version: German Sleep Society (Deutsche Gesellschaft für Schlafforschung und Schlafmedizin, DGSM)

Author

Mayer, Geert, Arzt, Michael, Braumann, Bert, Ficker, Joachim H., Fietze, Ingo, Frohnhofen, Helmut, Galetke, Wolfgang, Maurer, Joachim T., Orth, Maritta, Penzel, Thomas, Pistner, Hans, Randerath, Winfried, Rösslein, Martin, Sitter, Helmut, and Stuck, Boris A.

Published
2017
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82. Sleepmedical healthcare in Germany

Author

Stuck, Boris A., Schöbel, Christoph, and Spiegelhalder, K.

Subjects
Physiology (medical), Medizin
Abstract

Zusammenfassung Hintergrund Während eine aktuelle Analyse der schlafmedizinischen Qualifikationen in Deutschland Aussagen zu Anzahl und fachlichen Ausrichtung der Schlafmedizinerinnen erlaubt, sind tiefere Einblicke in die schlafmedizinische Versorgungsroutine bisher kaum möglich, wären für strategische Entscheidungen jedoch erforderlich. Methodik Schlafmedizinisch Tätige wurden zur Teilnahme an einem Online-Survey eingeladen. Erfasst wurden u. a. demografische Faktoren, schlafmedizinische Qualifikationen, Art und Häufigkeit der angebotenen diagnostischen und therapeutischen Verfahren, der Kenntnisstand zu Leitlinien und ausgewählten therapeutischen Verfahren und die Einschätzung zu Hindernissen in der Versorgung. Ergebnisse Beantwortet wurde der Survey von 435 Personen (Rücklaufquote 8,9 %). Es waren 62 % der Teilnehmerinnen zu etwa gleichen Teilen den Disziplinen Pneumologie und HNO-Heilkunde zugeordnet, 61,4 % hatte einen „BUB-Kurs“ absolviert und 44,1 % die Zusatzbezeichnung (ZB) Schlafmedizin erlangt. Mehr als 10 Jahre schlafmedizinisch tätig waren 72,2% der Teilnehmerinnen, 67,2 % im ambulanten Sektor. Nur ca. ein Viertel ist weiblich, das mittlere Alter lag bei 53 Jahren. Zur Diagnostik wird vornehmlich die Polygraphie angeboten (77,9 %), danach Screeningverfahren (36,3 %) und die stationäre (34,5 %) und ambulante (29,9 %) Polysomnographie. Als Schwerpunkte wurde in 88,7 % die obstruktive Schlafapnoe benannt. Kooperiert wird vornehmlich zwischen HNO-Heilkunde und Pneumologie. Etwa drei Viertel gaben an, die Leitlinien zu den schlafbezogenen Atmungsstörungen (SBAS) zu kennen, bzgl. der Leitlinie zur Insomnie waren es etwas weniger als die Hälfte. Schlussfolgerung Schlafmedizinisch tätig sind in Deutschland vor allem männliche Pneumologen und HNO-Ärzte mit den Qualifikationen „BUB-Kurs“ und ZB Schlafmedizin, die im ambulanten Sektor eine Diagnostik der SBAS anbieten. Die Daten deuten auf eine Unterversorgung von Patientinnen mit Insomnie hin. Es gibt derzeit kaum schlafmedizinischen Nachwuchs, was die Disziplin in ihrer Existenz gefährdet.

Published
2022

84. Praxis der Schlafmedizin

Author

Stuck, Boris A., primary, Maurer, Joachim T., additional, Schlarb, Angelika A., additional, Schredl, Michael, additional, and Weeß, Hans-Günter, additional

Published
2018
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85. Phytomedicine ELOM‐080 in Acute Viral Rhinosinusitis: A Randomized, Placebo‐Controlled, Blinded Clinical Trial.

Author

Pfaar, Oliver, Beule, Achim G., Jobst, Detmar, Kraft, Karin, Stammer, Holger, Röschmann‐Doose, Kristina I.L., Wittig, Thomas, and Stuck, Boris A.

Abstract

Background: ELOM‐080 is a phytomedicine approved for the treatment of acute and chronic inflammatory diseases of the respiratory tract, sinusitis, and bronchitis in particular. This prospective, randomized, placebo‐controlled, double‐blind clinical trial was conducted to assess efficacy and safety of ELOM‐080 in the treatment of acute viral rhinosinusitis (AVRS). Methods: Patients with AVRS received oral treatment (4 × 1 capsule per day) with either ELOM‐080 or matching placebo. Primary endpoints were the change in major symptom score (MSS) after 7 and 14 days of treatment assessed by the investigator (MSSINV). Secondary endpoints were changes in MSS assessed by the patients (MSSPAT), olfactory function (12‐item Sniffin' Sticks), 20‐Item Sino‐Nasal Outcome Test (SNOT‐20 GAV; German adapted version), influence of treatment on viral load, and safety. Results: Four hundred and sixty‐three patients were randomized. At day 4, subjective burden of disease (MSS) was significantly ameliorated compared to placebo (p = 0.012). During the first treatment week MSS scores improved about 1 day earlier, and 3 days earlier in the second week. Effect with ELOM‐080 on mean MSSINV was statistically significantly superior to placebo at visit 3 (p = 0.016) and visit 4 (p = 0.014). In chemosensory testing identification scores improved comparably in both treatments. The improvement of the SNOT‐20 GAV was more pronounced in ELOM‐080 patients. Treatment with ELOM‐080 indicated a potential for decreasing viral load. Both treatments were well tolerated. Conclusion: ELOM‐080 improves the burden of AVRS significantly in comparison to placebo, remission of symptoms occurred 3 days earlier. The results confirm the efficacy and safety of ELOM‐080 for treatment of AVRS. Level of Evidence: 1 Laryngoscope, 133:1576–1583, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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94. Generation of a Syngeneic Heterozygous ACVRL1 (wt/mut) Knockout iPS Cell Line for the In Vitro Study of HHT2-Associated Angiogenesis.

Author

Xiang-Tischhauser, Li, Bette, Michael, Rusche, Johanna R., Roth, Katrin, Kasahara, Norio, Stuck, Boris A., Bakowsky, Udo, Wartenberg, Maria, Sauer, Heinrich, Geisthoff, Urban W., and Mandic, Robert

Subjects
INDUCED pluripotent stem cells, NEOVASCULARIZATION, CELL lines, HEREDITARY hemorrhagic telangiectasia, FRAMESHIFT mutation, CELL culture, GENE expression
Abstract

Hereditary hemorrhagic telangiectasia (HHT) type 2 is an autosomal dominant disease in which one allele of the ACVRL1 gene is mutated. Patients exhibit disturbances in TGF-beta/BMP-dependent angiogenesis and, clinically, often present with severe nosebleeds as well as a reduced quality of life. The aim of our study was to use CRISPR/Cas9 to knockout ACVRL1 in normal induced pluripotent stem cells (iPSCs) and evaluate the effects on TGF-beta- and BMP-related gene expression as well as angiogenesis. The CRISPR/Cas9 knockout of the ACVRL1 gene was carried out in previously characterized wild-type (ACVRL1wt/wt) iPSCs. An HHT type 2 iPS cell line was generated via a single-allele knockout (ACVRL1wt/mut) in wild-type (ACVRL1wt/wt) iPSCs, resulting in a heterozygous 17 bp frameshift deletion in the ACVRL1 gene [NG_009549.1:g.13707_13723del; NM_000020.3:c.1137_1153del]. After the generation of embryoid bodies (EBs), endothelial differentiation was induced via adding 4 ng/mL BMP4, 2% B27, and 10 ng/mL VEGF. Endothelial differentiation was monitored via immunocytochemistry. An analysis of 151 TGF-beta/BMP-related genes was performed via RT-qPCR through the use of mRNA derived from single iPS cell cultures as well as endothelial cells derived from EBs after endothelial differentiation. Differential TGF-beta/BMP gene expression was observed between ACVRL1wt/wt and ACVRL1wt/mut iPSCs as well as endothelial cells. EBs derived from CRISPR/Cas9-designed ACVRL1 mutant HHT type 2 iPSCs, together with their isogenic wild-type iPSC counterparts, can serve as valuable resources for HHT type 2 in vitro studies. [ABSTRACT FROM AUTHOR]

Published
2023
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